-- dump date 20140619_082721 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1110693000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1110693000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1110693000003 putative catalytic residues [active] 1110693000004 putative nucleotide binding site [chemical binding]; other site 1110693000005 putative aspartate binding site [chemical binding]; other site 1110693000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1110693000007 dimer interface [polypeptide binding]; other site 1110693000008 putative threonine allosteric regulatory site; other site 1110693000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1110693000010 putative threonine allosteric regulatory site; other site 1110693000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1110693000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1110693000013 homoserine kinase; Region: thrB; TIGR00191 1110693000014 Protein of unknown function; Region: YhfT; pfam10797 1110693000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1110693000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1110693000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1110693000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693000019 catalytic residue [active] 1110693000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1110693000021 hypothetical protein; Validated; Region: PRK02101 1110693000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1110693000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1110693000024 transaldolase-like protein; Provisional; Region: PTZ00411 1110693000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1110693000026 active site 1110693000027 dimer interface [polypeptide binding]; other site 1110693000028 catalytic residue [active] 1110693000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1110693000030 MPT binding site; other site 1110693000031 trimer interface [polypeptide binding]; other site 1110693000032 hypothetical protein; Provisional; Region: PRK10659 1110693000033 hypothetical protein; Provisional; Region: PRK10236 1110693000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 1110693000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1110693000036 hypothetical protein; Provisional; Region: PRK10154 1110693000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1110693000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1110693000039 nucleotide binding site [chemical binding]; other site 1110693000040 NEF interaction site [polypeptide binding]; other site 1110693000041 SBD interface [polypeptide binding]; other site 1110693000042 chaperone protein DnaJ; Provisional; Region: PRK10767 1110693000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1110693000044 HSP70 interaction site [polypeptide binding]; other site 1110693000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1110693000046 substrate binding site [polypeptide binding]; other site 1110693000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1110693000048 Zn binding sites [ion binding]; other site 1110693000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1110693000050 dimer interface [polypeptide binding]; other site 1110693000051 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1110693000052 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 1110693000053 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1110693000054 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1110693000055 active site 1110693000056 Riboflavin kinase; Region: Flavokinase; smart00904 1110693000057 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1110693000058 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1110693000059 HIGH motif; other site 1110693000060 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1110693000061 active site 1110693000062 KMSKS motif; other site 1110693000063 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1110693000064 tRNA binding surface [nucleotide binding]; other site 1110693000065 anticodon binding site; other site 1110693000066 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1110693000067 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1110693000068 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1110693000069 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1110693000070 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1110693000071 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1110693000072 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1110693000073 active site 1110693000074 tetramer interface [polypeptide binding]; other site 1110693000075 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1110693000076 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1110693000077 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1110693000078 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1110693000079 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1110693000080 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1110693000081 catalytic site [active] 1110693000082 subunit interface [polypeptide binding]; other site 1110693000083 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1110693000084 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1110693000085 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1110693000086 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1110693000087 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1110693000088 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1110693000089 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1110693000090 IMP binding site; other site 1110693000091 dimer interface [polypeptide binding]; other site 1110693000092 interdomain contacts; other site 1110693000093 partial ornithine binding site; other site 1110693000094 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 1110693000095 carnitine operon protein CaiE; Provisional; Region: PRK13627 1110693000096 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1110693000097 putative trimer interface [polypeptide binding]; other site 1110693000098 putative metal binding site [ion binding]; other site 1110693000099 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1110693000100 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1110693000101 substrate binding site [chemical binding]; other site 1110693000102 oxyanion hole (OAH) forming residues; other site 1110693000103 trimer interface [polypeptide binding]; other site 1110693000104 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 1110693000105 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1110693000106 acyl-activating enzyme (AAE) consensus motif; other site 1110693000107 putative AMP binding site [chemical binding]; other site 1110693000108 putative active site [active] 1110693000109 putative CoA binding site [chemical binding]; other site 1110693000110 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 1110693000111 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1110693000112 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1110693000113 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1110693000114 active site 1110693000115 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 1110693000116 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1110693000117 Ligand binding site [chemical binding]; other site 1110693000118 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1110693000119 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 1110693000120 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 1110693000121 Ligand binding site [chemical binding]; other site 1110693000122 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1110693000123 putative oxidoreductase FixC; Provisional; Region: PRK10157 1110693000124 ferredoxin-like protein FixX; Provisional; Region: PRK15449 1110693000125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693000126 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1110693000127 putative substrate translocation pore; other site 1110693000128 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1110693000129 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1110693000130 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1110693000131 TrkA-N domain; Region: TrkA_N; pfam02254 1110693000132 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1110693000133 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1110693000134 folate binding site [chemical binding]; other site 1110693000135 NADP+ binding site [chemical binding]; other site 1110693000136 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1110693000137 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1110693000138 active site 1110693000139 metal binding site [ion binding]; metal-binding site 1110693000140 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1110693000141 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1110693000142 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1110693000143 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1110693000144 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1110693000145 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1110693000146 SurA N-terminal domain; Region: SurA_N; pfam09312 1110693000147 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1110693000148 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1110693000149 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1110693000150 OstA-like protein; Region: OstA; pfam03968 1110693000151 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1110693000152 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1110693000153 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1110693000154 putative metal binding site [ion binding]; other site 1110693000155 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1110693000156 HSP70 interaction site [polypeptide binding]; other site 1110693000157 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1110693000158 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1110693000159 active site 1110693000160 ATP-dependent helicase HepA; Validated; Region: PRK04914 1110693000161 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1110693000162 ATP binding site [chemical binding]; other site 1110693000163 putative Mg++ binding site [ion binding]; other site 1110693000164 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1110693000165 nucleotide binding region [chemical binding]; other site 1110693000166 ATP-binding site [chemical binding]; other site 1110693000167 DNA polymerase II; Reviewed; Region: PRK05762 1110693000168 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1110693000169 active site 1110693000170 catalytic site [active] 1110693000171 substrate binding site [chemical binding]; other site 1110693000172 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1110693000173 active site 1110693000174 metal-binding site 1110693000175 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1110693000176 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1110693000177 intersubunit interface [polypeptide binding]; other site 1110693000178 active site 1110693000179 Zn2+ binding site [ion binding]; other site 1110693000180 L-arabinose isomerase; Provisional; Region: PRK02929 1110693000181 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1110693000182 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1110693000183 trimer interface [polypeptide binding]; other site 1110693000184 putative substrate binding site [chemical binding]; other site 1110693000185 putative metal binding site [ion binding]; other site 1110693000186 ribulokinase; Provisional; Region: PRK04123 1110693000187 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1110693000188 N- and C-terminal domain interface [polypeptide binding]; other site 1110693000189 active site 1110693000190 MgATP binding site [chemical binding]; other site 1110693000191 catalytic site [active] 1110693000192 metal binding site [ion binding]; metal-binding site 1110693000193 carbohydrate binding site [chemical binding]; other site 1110693000194 homodimer interface [polypeptide binding]; other site 1110693000195 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1110693000196 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1110693000197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693000198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693000199 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1110693000200 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1110693000201 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1110693000202 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1110693000203 Walker A/P-loop; other site 1110693000204 ATP binding site [chemical binding]; other site 1110693000205 Q-loop/lid; other site 1110693000206 ABC transporter signature motif; other site 1110693000207 Walker B; other site 1110693000208 D-loop; other site 1110693000209 H-loop/switch region; other site 1110693000210 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1110693000211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693000212 dimer interface [polypeptide binding]; other site 1110693000213 conserved gate region; other site 1110693000214 putative PBP binding loops; other site 1110693000215 ABC-ATPase subunit interface; other site 1110693000216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693000217 dimer interface [polypeptide binding]; other site 1110693000218 conserved gate region; other site 1110693000219 putative PBP binding loops; other site 1110693000220 ABC-ATPase subunit interface; other site 1110693000221 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1110693000222 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1110693000223 transcriptional regulator SgrR; Provisional; Region: PRK13626 1110693000224 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1110693000225 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1110693000226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693000227 sugar efflux transporter; Region: 2A0120; TIGR00899 1110693000228 putative substrate translocation pore; other site 1110693000229 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1110693000230 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1110693000231 substrate binding site [chemical binding]; other site 1110693000232 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1110693000233 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1110693000234 substrate binding site [chemical binding]; other site 1110693000235 ligand binding site [chemical binding]; other site 1110693000236 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1110693000237 tartrate dehydrogenase; Region: TTC; TIGR02089 1110693000238 2-isopropylmalate synthase; Validated; Region: PRK00915 1110693000239 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1110693000240 active site 1110693000241 catalytic residues [active] 1110693000242 metal binding site [ion binding]; metal-binding site 1110693000243 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1110693000244 leu operon leader peptide; Provisional; Region: PRK09925 1110693000245 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1110693000246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693000247 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1110693000248 putative substrate binding pocket [chemical binding]; other site 1110693000249 putative dimerization interface [polypeptide binding]; other site 1110693000250 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1110693000251 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1110693000252 PYR/PP interface [polypeptide binding]; other site 1110693000253 dimer interface [polypeptide binding]; other site 1110693000254 TPP binding site [chemical binding]; other site 1110693000255 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1110693000256 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1110693000257 TPP-binding site [chemical binding]; other site 1110693000258 dimer interface [polypeptide binding]; other site 1110693000259 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1110693000260 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1110693000261 putative valine binding site [chemical binding]; other site 1110693000262 dimer interface [polypeptide binding]; other site 1110693000263 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1110693000264 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1110693000265 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693000266 DNA binding site [nucleotide binding] 1110693000267 domain linker motif; other site 1110693000268 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1110693000269 dimerization interface [polypeptide binding]; other site 1110693000270 ligand binding site [chemical binding]; other site 1110693000271 mraZ protein; Region: TIGR00242 1110693000272 MraZ protein; Region: MraZ; pfam02381 1110693000273 MraZ protein; Region: MraZ; pfam02381 1110693000274 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1110693000275 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1110693000276 cell division protein FtsL; Provisional; Region: PRK10772 1110693000277 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1110693000278 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1110693000279 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1110693000280 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1110693000281 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1110693000282 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1110693000283 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1110693000284 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1110693000285 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1110693000286 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1110693000287 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1110693000288 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1110693000289 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1110693000290 Mg++ binding site [ion binding]; other site 1110693000291 putative catalytic motif [active] 1110693000292 putative substrate binding site [chemical binding]; other site 1110693000293 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1110693000294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1110693000295 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1110693000296 cell division protein FtsW; Provisional; Region: PRK10774 1110693000297 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1110693000298 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1110693000299 active site 1110693000300 homodimer interface [polypeptide binding]; other site 1110693000301 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1110693000302 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1110693000303 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1110693000304 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1110693000305 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1110693000306 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1110693000307 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1110693000308 cell division protein FtsQ; Provisional; Region: PRK10775 1110693000309 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1110693000310 Cell division protein FtsQ; Region: FtsQ; pfam03799 1110693000311 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1110693000312 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1110693000313 Cell division protein FtsA; Region: FtsA; pfam14450 1110693000314 cell division protein FtsZ; Validated; Region: PRK09330 1110693000315 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1110693000316 nucleotide binding site [chemical binding]; other site 1110693000317 SulA interaction site; other site 1110693000318 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1110693000319 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1110693000320 SecA regulator SecM; Provisional; Region: PRK02943 1110693000321 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1110693000322 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1110693000323 SEC-C motif; Region: SEC-C; pfam02810 1110693000324 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1110693000325 active site 1110693000326 8-oxo-dGMP binding site [chemical binding]; other site 1110693000327 nudix motif; other site 1110693000328 metal binding site [ion binding]; metal-binding site 1110693000329 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1110693000330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1110693000331 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1110693000332 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1110693000333 CoA-binding site [chemical binding]; other site 1110693000334 ATP-binding [chemical binding]; other site 1110693000335 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1110693000336 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1110693000337 active site 1110693000338 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1110693000339 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1110693000340 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1110693000341 hypothetical protein; Provisional; Region: PRK10436 1110693000342 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1110693000343 Walker A motif; other site 1110693000344 ATP binding site [chemical binding]; other site 1110693000345 Walker B motif; other site 1110693000346 putative major pilin subunit; Provisional; Region: PRK10574 1110693000347 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1110693000348 Pilin (bacterial filament); Region: Pilin; pfam00114 1110693000349 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1110693000350 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1110693000351 dimerization interface [polypeptide binding]; other site 1110693000352 active site 1110693000353 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1110693000354 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1110693000355 amidase catalytic site [active] 1110693000356 Zn binding residues [ion binding]; other site 1110693000357 substrate binding site [chemical binding]; other site 1110693000358 regulatory protein AmpE; Provisional; Region: PRK10987 1110693000359 aromatic amino acid transporter; Provisional; Region: PRK10238 1110693000360 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1110693000361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693000362 DNA-binding site [nucleotide binding]; DNA binding site 1110693000363 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1110693000364 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1110693000365 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1110693000366 dimer interface [polypeptide binding]; other site 1110693000367 TPP-binding site [chemical binding]; other site 1110693000368 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1110693000369 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1110693000370 E3 interaction surface; other site 1110693000371 lipoyl attachment site [posttranslational modification]; other site 1110693000372 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1110693000373 E3 interaction surface; other site 1110693000374 lipoyl attachment site [posttranslational modification]; other site 1110693000375 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1110693000376 E3 interaction surface; other site 1110693000377 lipoyl attachment site [posttranslational modification]; other site 1110693000378 e3 binding domain; Region: E3_binding; pfam02817 1110693000379 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1110693000380 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1110693000381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1110693000382 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693000383 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1110693000384 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1110693000385 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 1110693000386 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1110693000387 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1110693000388 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1110693000389 substrate binding site [chemical binding]; other site 1110693000390 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1110693000391 substrate binding site [chemical binding]; other site 1110693000392 ligand binding site [chemical binding]; other site 1110693000393 hypothetical protein; Provisional; Region: PRK05248 1110693000394 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1110693000395 spermidine synthase; Provisional; Region: PRK00811 1110693000396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693000397 S-adenosylmethionine binding site [chemical binding]; other site 1110693000398 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1110693000399 multicopper oxidase; Provisional; Region: PRK10965 1110693000400 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1110693000401 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1110693000402 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1110693000403 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1110693000404 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1110693000405 Trp docking motif [polypeptide binding]; other site 1110693000406 putative active site [active] 1110693000407 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1110693000408 active site 1110693000409 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1110693000410 active site clefts [active] 1110693000411 zinc binding site [ion binding]; other site 1110693000412 dimer interface [polypeptide binding]; other site 1110693000413 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1110693000414 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1110693000415 Walker A/P-loop; other site 1110693000416 ATP binding site [chemical binding]; other site 1110693000417 Q-loop/lid; other site 1110693000418 ABC transporter signature motif; other site 1110693000419 Walker B; other site 1110693000420 D-loop; other site 1110693000421 H-loop/switch region; other site 1110693000422 inner membrane transport permease; Provisional; Region: PRK15066 1110693000423 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1110693000424 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1110693000425 active pocket/dimerization site; other site 1110693000426 active site 1110693000427 phosphorylation site [posttranslational modification] 1110693000428 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1110693000429 putative active site [active] 1110693000430 putative metal binding site [ion binding]; other site 1110693000431 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1110693000432 tetramerization interface [polypeptide binding]; other site 1110693000433 active site 1110693000434 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1110693000435 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1110693000436 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1110693000437 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1110693000438 active site 1110693000439 ATP-binding site [chemical binding]; other site 1110693000440 pantoate-binding site; other site 1110693000441 HXXH motif; other site 1110693000442 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1110693000443 oligomerization interface [polypeptide binding]; other site 1110693000444 active site 1110693000445 metal binding site [ion binding]; metal-binding site 1110693000446 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 1110693000447 putative fimbrial protein StaF; Provisional; Region: PRK15262 1110693000448 putative fimbrial protein StaE; Provisional; Region: PRK15263 1110693000449 Fimbrial protein; Region: Fimbrial; cl01416 1110693000450 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 1110693000451 PapC N-terminal domain; Region: PapC_N; pfam13954 1110693000452 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1110693000453 PapC C-terminal domain; Region: PapC_C; pfam13953 1110693000454 putative chaperone protein EcpD; Provisional; Region: PRK09926 1110693000455 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1110693000456 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1110693000457 Fimbrial protein; Region: Fimbrial; cl01416 1110693000458 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1110693000459 catalytic center binding site [active] 1110693000460 ATP binding site [chemical binding]; other site 1110693000461 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1110693000462 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1110693000463 active site 1110693000464 NTP binding site [chemical binding]; other site 1110693000465 metal binding triad [ion binding]; metal-binding site 1110693000466 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1110693000467 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1110693000468 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1110693000469 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1110693000470 active site 1110693000471 nucleotide binding site [chemical binding]; other site 1110693000472 HIGH motif; other site 1110693000473 KMSKS motif; other site 1110693000474 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1110693000475 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1110693000476 2'-5' RNA ligase; Provisional; Region: PRK15124 1110693000477 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1110693000478 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1110693000479 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1110693000480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1110693000481 ATP binding site [chemical binding]; other site 1110693000482 putative Mg++ binding site [ion binding]; other site 1110693000483 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1110693000484 nucleotide binding region [chemical binding]; other site 1110693000485 ATP-binding site [chemical binding]; other site 1110693000486 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1110693000487 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1110693000488 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1110693000489 Transglycosylase; Region: Transgly; pfam00912 1110693000490 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1110693000491 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1110693000492 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1110693000493 inhibitor-cofactor binding pocket; inhibition site 1110693000494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693000495 catalytic residue [active] 1110693000496 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1110693000497 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1110693000498 Cl- selectivity filter; other site 1110693000499 Cl- binding residues [ion binding]; other site 1110693000500 pore gating glutamate residue; other site 1110693000501 dimer interface [polypeptide binding]; other site 1110693000502 H+/Cl- coupling transport residue; other site 1110693000503 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1110693000504 hypothetical protein; Provisional; Region: PRK10578 1110693000505 UPF0126 domain; Region: UPF0126; pfam03458 1110693000506 UPF0126 domain; Region: UPF0126; pfam03458 1110693000507 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1110693000508 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1110693000509 cobalamin binding residues [chemical binding]; other site 1110693000510 putative BtuC binding residues; other site 1110693000511 dimer interface [polypeptide binding]; other site 1110693000512 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1110693000513 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1110693000514 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1110693000515 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1110693000516 Zn2+ binding site [ion binding]; other site 1110693000517 Mg2+ binding site [ion binding]; other site 1110693000518 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1110693000519 serine endoprotease; Provisional; Region: PRK10942 1110693000520 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1110693000521 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1110693000522 protein binding site [polypeptide binding]; other site 1110693000523 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1110693000524 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1110693000525 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1110693000526 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1110693000527 hypothetical protein; Provisional; Region: PRK13677 1110693000528 phosphodiesterase YaeI; Provisional; Region: PRK11340 1110693000529 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1110693000530 putative active site [active] 1110693000531 putative metal binding site [ion binding]; other site 1110693000532 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1110693000533 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1110693000534 trimer interface [polypeptide binding]; other site 1110693000535 active site 1110693000536 substrate binding site [chemical binding]; other site 1110693000537 CoA binding site [chemical binding]; other site 1110693000538 PII uridylyl-transferase; Provisional; Region: PRK05007 1110693000539 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1110693000540 metal binding triad; other site 1110693000541 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1110693000542 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1110693000543 Zn2+ binding site [ion binding]; other site 1110693000544 Mg2+ binding site [ion binding]; other site 1110693000545 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1110693000546 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1110693000547 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1110693000548 active site 1110693000549 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1110693000550 rRNA interaction site [nucleotide binding]; other site 1110693000551 S8 interaction site; other site 1110693000552 putative laminin-1 binding site; other site 1110693000553 elongation factor Ts; Provisional; Region: tsf; PRK09377 1110693000554 UBA/TS-N domain; Region: UBA; pfam00627 1110693000555 Elongation factor TS; Region: EF_TS; pfam00889 1110693000556 Elongation factor TS; Region: EF_TS; pfam00889 1110693000557 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1110693000558 putative nucleotide binding site [chemical binding]; other site 1110693000559 uridine monophosphate binding site [chemical binding]; other site 1110693000560 homohexameric interface [polypeptide binding]; other site 1110693000561 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1110693000562 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1110693000563 hinge region; other site 1110693000564 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1110693000565 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1110693000566 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1110693000567 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1110693000568 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1110693000569 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1110693000570 catalytic residue [active] 1110693000571 putative FPP diphosphate binding site; other site 1110693000572 putative FPP binding hydrophobic cleft; other site 1110693000573 dimer interface [polypeptide binding]; other site 1110693000574 putative IPP diphosphate binding site; other site 1110693000575 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1110693000576 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1110693000577 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1110693000578 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1110693000579 active site 1110693000580 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1110693000581 protein binding site [polypeptide binding]; other site 1110693000582 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1110693000583 putative substrate binding region [chemical binding]; other site 1110693000584 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1110693000585 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1110693000586 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1110693000587 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1110693000588 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1110693000589 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1110693000590 Surface antigen; Region: Bac_surface_Ag; pfam01103 1110693000591 periplasmic chaperone; Provisional; Region: PRK10780 1110693000592 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1110693000593 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1110693000594 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1110693000595 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1110693000596 trimer interface [polypeptide binding]; other site 1110693000597 active site 1110693000598 UDP-GlcNAc binding site [chemical binding]; other site 1110693000599 lipid binding site [chemical binding]; lipid-binding site 1110693000600 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1110693000601 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1110693000602 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1110693000603 active site 1110693000604 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1110693000605 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1110693000606 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1110693000607 RNA/DNA hybrid binding site [nucleotide binding]; other site 1110693000608 active site 1110693000609 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1110693000610 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1110693000611 putative active site [active] 1110693000612 putative PHP Thumb interface [polypeptide binding]; other site 1110693000613 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1110693000614 generic binding surface II; other site 1110693000615 generic binding surface I; other site 1110693000616 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1110693000617 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1110693000618 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1110693000619 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1110693000620 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1110693000621 homodimer interface [polypeptide binding]; other site 1110693000622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693000623 catalytic residue [active] 1110693000624 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1110693000625 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1110693000626 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1110693000627 putative metal binding site [ion binding]; other site 1110693000628 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1110693000629 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1110693000630 Ligand Binding Site [chemical binding]; other site 1110693000631 TilS substrate binding domain; Region: TilS; pfam09179 1110693000632 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1110693000633 Rho-binding antiterminator; Provisional; Region: PRK11625 1110693000634 hypothetical protein; Provisional; Region: PRK04964 1110693000635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1110693000636 hypothetical protein; Provisional; Region: PRK09256 1110693000637 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1110693000638 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1110693000639 NlpE N-terminal domain; Region: NlpE; pfam04170 1110693000640 hypothetical protein; Provisional; Region: PRK11479 1110693000641 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1110693000642 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1110693000643 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1110693000644 dimer interface [polypeptide binding]; other site 1110693000645 motif 1; other site 1110693000646 active site 1110693000647 motif 2; other site 1110693000648 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1110693000649 putative deacylase active site [active] 1110693000650 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1110693000651 active site 1110693000652 motif 3; other site 1110693000653 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1110693000654 anticodon binding site; other site 1110693000655 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1110693000656 homodimer interaction site [polypeptide binding]; other site 1110693000657 cofactor binding site; other site 1110693000658 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1110693000659 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1110693000660 lipoprotein, YaeC family; Region: TIGR00363 1110693000661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693000662 dimer interface [polypeptide binding]; other site 1110693000663 conserved gate region; other site 1110693000664 ABC-ATPase subunit interface; other site 1110693000665 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1110693000666 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1110693000667 Walker A/P-loop; other site 1110693000668 ATP binding site [chemical binding]; other site 1110693000669 Q-loop/lid; other site 1110693000670 ABC transporter signature motif; other site 1110693000671 Walker B; other site 1110693000672 D-loop; other site 1110693000673 H-loop/switch region; other site 1110693000674 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1110693000675 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 1110693000676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693000677 active site 1110693000678 motif I; other site 1110693000679 motif II; other site 1110693000680 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1110693000681 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1110693000682 active site 1110693000683 catalytic tetrad [active] 1110693000684 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1110693000685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693000686 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1110693000687 putative effector binding pocket; other site 1110693000688 dimerization interface [polypeptide binding]; other site 1110693000689 hypothetical protein; Provisional; Region: PRK05421 1110693000690 putative catalytic site [active] 1110693000691 putative metal binding site [ion binding]; other site 1110693000692 putative phosphate binding site [ion binding]; other site 1110693000693 putative catalytic site [active] 1110693000694 putative phosphate binding site [ion binding]; other site 1110693000695 putative metal binding site [ion binding]; other site 1110693000696 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1110693000697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693000698 S-adenosylmethionine binding site [chemical binding]; other site 1110693000699 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1110693000700 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1110693000701 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1110693000702 catalytic residue [active] 1110693000703 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1110693000704 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1110693000705 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1110693000706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693000707 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1110693000708 RNA/DNA hybrid binding site [nucleotide binding]; other site 1110693000709 active site 1110693000710 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1110693000711 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1110693000712 active site 1110693000713 catalytic site [active] 1110693000714 substrate binding site [chemical binding]; other site 1110693000715 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1110693000716 C-N hydrolase family amidase; Provisional; Region: PRK10438 1110693000717 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1110693000718 putative active site [active] 1110693000719 catalytic triad [active] 1110693000720 dimer interface [polypeptide binding]; other site 1110693000721 multimer interface [polypeptide binding]; other site 1110693000722 C-lysozyme inhibitor; Provisional; Region: PRK09993 1110693000723 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1110693000724 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1110693000725 active site 1110693000726 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1110693000727 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1110693000728 dimer interface [polypeptide binding]; other site 1110693000729 active site 1110693000730 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1110693000731 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1110693000732 putative active site [active] 1110693000733 putative dimer interface [polypeptide binding]; other site 1110693000734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1110693000735 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1110693000736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 1110693000737 RelB antitoxin; Region: RelB; pfam04221 1110693000738 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1110693000739 NlpC/P60 family; Region: NLPC_P60; pfam00877 1110693000740 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1110693000741 flagellar system protein, promoterless fragment (pseudogene) 1110693000742 flagellar system protein, promoterless fragment (pseudogene) 1110693000743 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1110693000744 active site 1110693000745 DNA polymerase IV; Validated; Region: PRK02406 1110693000746 DNA binding site [nucleotide binding] 1110693000747 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 1110693000748 putative toxin YafO; Provisional; Region: PRK09885 1110693000749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1110693000750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1110693000751 Coenzyme A binding pocket [chemical binding]; other site 1110693000752 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1110693000753 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1110693000754 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1110693000755 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1110693000756 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1110693000757 metal binding site [ion binding]; metal-binding site 1110693000758 dimer interface [polypeptide binding]; other site 1110693000759 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1110693000760 active site 1110693000761 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1110693000762 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1110693000763 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1110693000764 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1110693000765 trimer interface [polypeptide binding]; other site 1110693000766 eyelet of channel; other site 1110693000767 gamma-glutamyl kinase; Provisional; Region: PRK05429 1110693000768 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1110693000769 nucleotide binding site [chemical binding]; other site 1110693000770 homotetrameric interface [polypeptide binding]; other site 1110693000771 putative phosphate binding site [ion binding]; other site 1110693000772 putative allosteric binding site; other site 1110693000773 PUA domain; Region: PUA; pfam01472 1110693000774 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1110693000775 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1110693000776 putative catalytic cysteine [active] 1110693000777 choline dehydrogenase; Validated; Region: PRK02106 1110693000778 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1110693000779 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1110693000780 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1110693000781 tetrameric interface [polypeptide binding]; other site 1110693000782 NAD binding site [chemical binding]; other site 1110693000783 catalytic residues [active] 1110693000784 transcriptional regulator BetI; Validated; Region: PRK00767 1110693000785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1110693000786 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1110693000787 choline transport protein BetT; Provisional; Region: PRK09928 1110693000788 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693000789 DNA binding residues [nucleotide binding] 1110693000790 dimerization interface [polypeptide binding]; other site 1110693000791 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1110693000792 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1110693000793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693000794 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1110693000795 dimerization interface [polypeptide binding]; other site 1110693000796 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1110693000797 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1110693000798 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1110693000799 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1110693000800 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1110693000801 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 1110693000802 CoA binding domain; Region: CoA_binding; pfam02629 1110693000803 CoA-ligase; Region: Ligase_CoA; pfam00549 1110693000804 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1110693000805 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1110693000806 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1110693000807 putative substrate binding site [chemical binding]; other site 1110693000808 nucleotide binding site [chemical binding]; other site 1110693000809 nucleotide binding site [chemical binding]; other site 1110693000810 homodimer interface [polypeptide binding]; other site 1110693000811 putative deaminase; Validated; Region: PRK06846 1110693000812 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1110693000813 active site 1110693000814 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1110693000815 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1110693000816 putative NAD(P) binding site [chemical binding]; other site 1110693000817 putative substrate binding site [chemical binding]; other site 1110693000818 catalytic Zn binding site [ion binding]; other site 1110693000819 structural Zn binding site [ion binding]; other site 1110693000820 dimer interface [polypeptide binding]; other site 1110693000821 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1110693000822 hypothetical protein; Provisional; Region: PRK09929 1110693000823 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 1110693000824 Propionate catabolism activator; Region: PrpR_N; pfam06506 1110693000825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693000826 Walker A motif; other site 1110693000827 ATP binding site [chemical binding]; other site 1110693000828 Walker B motif; other site 1110693000829 arginine finger; other site 1110693000830 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1110693000831 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1110693000832 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1110693000833 tetramer interface [polypeptide binding]; other site 1110693000834 active site 1110693000835 Mg2+/Mn2+ binding site [ion binding]; other site 1110693000836 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1110693000837 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1110693000838 dimer interface [polypeptide binding]; other site 1110693000839 active site 1110693000840 citrylCoA binding site [chemical binding]; other site 1110693000841 oxalacetate/citrate binding site [chemical binding]; other site 1110693000842 coenzyme A binding site [chemical binding]; other site 1110693000843 catalytic triad [active] 1110693000844 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1110693000845 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1110693000846 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1110693000847 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1110693000848 acyl-activating enzyme (AAE) consensus motif; other site 1110693000849 putative AMP binding site [chemical binding]; other site 1110693000850 putative active site [active] 1110693000851 putative CoA binding site [chemical binding]; other site 1110693000852 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1110693000853 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1110693000854 Na binding site [ion binding]; other site 1110693000855 putative substrate binding site [chemical binding]; other site 1110693000856 cytosine deaminase; Provisional; Region: PRK09230 1110693000857 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1110693000858 active site 1110693000859 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1110693000860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693000861 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1110693000862 dimerization interface [polypeptide binding]; other site 1110693000863 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1110693000864 active site clefts [active] 1110693000865 zinc binding site [ion binding]; other site 1110693000866 dimer interface [polypeptide binding]; other site 1110693000867 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 1110693000868 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1110693000869 oligomer interface [polypeptide binding]; other site 1110693000870 active site 1110693000871 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1110693000872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693000873 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1110693000874 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1110693000875 active site 1110693000876 substrate binding site [chemical binding]; other site 1110693000877 trimer interface [polypeptide binding]; other site 1110693000878 CoA binding site [chemical binding]; other site 1110693000879 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 1110693000880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693000881 putative substrate translocation pore; other site 1110693000882 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1110693000883 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1110693000884 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1110693000885 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1110693000886 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1110693000887 lac repressor; Reviewed; Region: lacI; PRK09526 1110693000888 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693000889 DNA binding site [nucleotide binding] 1110693000890 domain linker motif; other site 1110693000891 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1110693000892 ligand binding site [chemical binding]; other site 1110693000893 dimerization interface (open form) [polypeptide binding]; other site 1110693000894 dimerization interface (closed form) [polypeptide binding]; other site 1110693000895 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1110693000896 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1110693000897 Bacterial transcriptional regulator; Region: IclR; pfam01614 1110693000898 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1110693000899 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1110693000900 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 1110693000901 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1110693000902 putative active site [active] 1110693000903 Fe(II) binding site [ion binding]; other site 1110693000904 putative dimer interface [polypeptide binding]; other site 1110693000905 putative tetramer interface [polypeptide binding]; other site 1110693000906 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1110693000907 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1110693000908 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 1110693000909 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1110693000910 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1110693000911 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1110693000912 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1110693000913 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1110693000914 active site 1110693000915 catalytic residues [active] 1110693000916 metal binding site [ion binding]; metal-binding site 1110693000917 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1110693000918 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1110693000919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693000920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693000921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1110693000922 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1110693000923 S-formylglutathione hydrolase; Region: PLN02442 1110693000924 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1110693000925 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1110693000926 substrate binding site [chemical binding]; other site 1110693000927 catalytic Zn binding site [ion binding]; other site 1110693000928 NAD binding site [chemical binding]; other site 1110693000929 structural Zn binding site [ion binding]; other site 1110693000930 dimer interface [polypeptide binding]; other site 1110693000931 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1110693000932 putative metal binding site [ion binding]; other site 1110693000933 putative homodimer interface [polypeptide binding]; other site 1110693000934 putative homotetramer interface [polypeptide binding]; other site 1110693000935 putative homodimer-homodimer interface [polypeptide binding]; other site 1110693000936 putative allosteric switch controlling residues; other site 1110693000937 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1110693000938 dimer interface [polypeptide binding]; other site 1110693000939 active site 1110693000940 Schiff base residues; other site 1110693000941 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1110693000942 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1110693000943 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1110693000944 anti-RssB factor; Provisional; Region: PRK10244 1110693000945 alkaline phosphatase; Provisional; Region: PRK10518 1110693000946 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1110693000947 dimer interface [polypeptide binding]; other site 1110693000948 active site 1110693000949 hypothetical protein; Provisional; Region: PRK11505 1110693000950 psiF repeat; Region: PsiF_repeat; pfam07769 1110693000951 psiF repeat; Region: PsiF_repeat; pfam07769 1110693000952 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1110693000953 MASE2 domain; Region: MASE2; pfam05230 1110693000954 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693000955 metal binding site [ion binding]; metal-binding site 1110693000956 active site 1110693000957 I-site; other site 1110693000958 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1110693000959 pyrroline-5-carboxylate reductase; Region: PLN02688 1110693000960 hypothetical protein; Validated; Region: PRK00124 1110693000961 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1110693000962 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1110693000963 ADP binding site [chemical binding]; other site 1110693000964 magnesium binding site [ion binding]; other site 1110693000965 putative shikimate binding site; other site 1110693000966 hypothetical protein; Provisional; Region: PRK10380 1110693000967 hypothetical protein; Provisional; Region: PRK10481 1110693000968 hypothetical protein; Provisional; Region: PRK10579 1110693000969 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 1110693000970 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1110693000971 fructokinase; Reviewed; Region: PRK09557 1110693000972 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1110693000973 nucleotide binding site [chemical binding]; other site 1110693000974 MFS transport protein AraJ; Provisional; Region: PRK10091 1110693000975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693000976 putative substrate translocation pore; other site 1110693000977 exonuclease subunit SbcC; Provisional; Region: PRK10246 1110693000978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693000979 Walker A/P-loop; other site 1110693000980 ATP binding site [chemical binding]; other site 1110693000981 Q-loop/lid; other site 1110693000982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693000983 ABC transporter signature motif; other site 1110693000984 Walker B; other site 1110693000985 D-loop; other site 1110693000986 H-loop/switch region; other site 1110693000987 exonuclease subunit SbcD; Provisional; Region: PRK10966 1110693000988 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1110693000989 active site 1110693000990 metal binding site [ion binding]; metal-binding site 1110693000991 DNA binding site [nucleotide binding] 1110693000992 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1110693000993 transcriptional regulator PhoB; Provisional; Region: PRK10161 1110693000994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693000995 active site 1110693000996 phosphorylation site [posttranslational modification] 1110693000997 intermolecular recognition site; other site 1110693000998 dimerization interface [polypeptide binding]; other site 1110693000999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693001000 DNA binding site [nucleotide binding] 1110693001001 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1110693001002 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1110693001003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1110693001004 putative active site [active] 1110693001005 heme pocket [chemical binding]; other site 1110693001006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693001007 dimer interface [polypeptide binding]; other site 1110693001008 phosphorylation site [posttranslational modification] 1110693001009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693001010 ATP binding site [chemical binding]; other site 1110693001011 Mg2+ binding site [ion binding]; other site 1110693001012 G-X-G motif; other site 1110693001013 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1110693001014 putative proline-specific permease; Provisional; Region: proY; PRK10580 1110693001015 Spore germination protein; Region: Spore_permease; cl17796 1110693001016 maltodextrin glucosidase; Provisional; Region: PRK10785 1110693001017 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1110693001018 homodimer interface [polypeptide binding]; other site 1110693001019 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1110693001020 active site 1110693001021 homodimer interface [polypeptide binding]; other site 1110693001022 catalytic site [active] 1110693001023 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1110693001024 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1110693001025 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1110693001026 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1110693001027 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1110693001028 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1110693001029 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1110693001030 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1110693001031 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1110693001032 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1110693001033 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1110693001034 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1110693001035 Protein export membrane protein; Region: SecD_SecF; pfam02355 1110693001036 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1110693001037 active site 1110693001038 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1110693001039 hypothetical protein; Provisional; Region: PRK11530 1110693001040 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1110693001041 ATP cone domain; Region: ATP-cone; pfam03477 1110693001042 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1110693001043 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1110693001044 catalytic motif [active] 1110693001045 Zn binding site [ion binding]; other site 1110693001046 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1110693001047 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1110693001048 homopentamer interface [polypeptide binding]; other site 1110693001049 active site 1110693001050 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1110693001051 putative RNA binding site [nucleotide binding]; other site 1110693001052 thiamine monophosphate kinase; Provisional; Region: PRK05731 1110693001053 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1110693001054 ATP binding site [chemical binding]; other site 1110693001055 dimerization interface [polypeptide binding]; other site 1110693001056 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1110693001057 tetramer interfaces [polypeptide binding]; other site 1110693001058 binuclear metal-binding site [ion binding]; other site 1110693001059 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1110693001060 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1110693001061 active site 1110693001062 catalytic tetrad [active] 1110693001063 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1110693001064 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1110693001065 TPP-binding site; other site 1110693001066 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1110693001067 PYR/PP interface [polypeptide binding]; other site 1110693001068 dimer interface [polypeptide binding]; other site 1110693001069 TPP binding site [chemical binding]; other site 1110693001070 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1110693001071 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1110693001072 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1110693001073 substrate binding pocket [chemical binding]; other site 1110693001074 chain length determination region; other site 1110693001075 substrate-Mg2+ binding site; other site 1110693001076 catalytic residues [active] 1110693001077 aspartate-rich region 1; other site 1110693001078 active site lid residues [active] 1110693001079 aspartate-rich region 2; other site 1110693001080 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1110693001081 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1110693001082 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1110693001083 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1110693001084 Ligand Binding Site [chemical binding]; other site 1110693001085 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1110693001086 active site residue [active] 1110693001087 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1110693001088 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1110693001089 conserved cys residue [active] 1110693001090 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1110693001091 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1110693001092 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1110693001093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1110693001094 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1110693001095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693001096 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1110693001097 putative substrate translocation pore; other site 1110693001098 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1110693001099 UbiA prenyltransferase family; Region: UbiA; pfam01040 1110693001100 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1110693001101 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1110693001102 Subunit I/III interface [polypeptide binding]; other site 1110693001103 Subunit III/IV interface [polypeptide binding]; other site 1110693001104 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1110693001105 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1110693001106 D-pathway; other site 1110693001107 Putative ubiquinol binding site [chemical binding]; other site 1110693001108 Low-spin heme (heme b) binding site [chemical binding]; other site 1110693001109 Putative water exit pathway; other site 1110693001110 Binuclear center (heme o3/CuB) [ion binding]; other site 1110693001111 K-pathway; other site 1110693001112 Putative proton exit pathway; other site 1110693001113 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1110693001114 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1110693001115 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1110693001116 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1110693001117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693001118 putative substrate translocation pore; other site 1110693001119 hypothetical protein; Provisional; Region: PRK11627 1110693001120 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1110693001121 transcriptional regulator BolA; Provisional; Region: PRK11628 1110693001122 trigger factor; Provisional; Region: tig; PRK01490 1110693001123 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1110693001124 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1110693001125 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1110693001126 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1110693001127 oligomer interface [polypeptide binding]; other site 1110693001128 active site residues [active] 1110693001129 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1110693001130 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1110693001131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693001132 Walker A motif; other site 1110693001133 ATP binding site [chemical binding]; other site 1110693001134 Walker B motif; other site 1110693001135 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1110693001136 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1110693001137 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1110693001138 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1110693001139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693001140 Walker A motif; other site 1110693001141 ATP binding site [chemical binding]; other site 1110693001142 Walker B motif; other site 1110693001143 arginine finger; other site 1110693001144 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1110693001145 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1110693001146 IHF dimer interface [polypeptide binding]; other site 1110693001147 IHF - DNA interface [nucleotide binding]; other site 1110693001148 periplasmic folding chaperone; Provisional; Region: PRK10788 1110693001149 SurA N-terminal domain; Region: SurA_N_3; cl07813 1110693001150 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1110693001151 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1110693001152 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1110693001153 active site 1110693001154 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1110693001155 Ligand Binding Site [chemical binding]; other site 1110693001156 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1110693001157 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1110693001158 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1110693001159 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1110693001160 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693001161 active site 1110693001162 motif I; other site 1110693001163 motif II; other site 1110693001164 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1110693001165 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1110693001166 putative DNA binding site [nucleotide binding]; other site 1110693001167 putative Zn2+ binding site [ion binding]; other site 1110693001168 AsnC family; Region: AsnC_trans_reg; pfam01037 1110693001169 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1110693001170 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1110693001171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693001172 Walker A/P-loop; other site 1110693001173 ATP binding site [chemical binding]; other site 1110693001174 Q-loop/lid; other site 1110693001175 ABC transporter signature motif; other site 1110693001176 Walker B; other site 1110693001177 D-loop; other site 1110693001178 H-loop/switch region; other site 1110693001179 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1110693001180 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1110693001181 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1110693001182 Walker A/P-loop; other site 1110693001183 ATP binding site [chemical binding]; other site 1110693001184 Q-loop/lid; other site 1110693001185 ABC transporter signature motif; other site 1110693001186 Walker B; other site 1110693001187 D-loop; other site 1110693001188 H-loop/switch region; other site 1110693001189 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1110693001190 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1110693001191 ammonium transporter; Provisional; Region: PRK10666 1110693001192 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1110693001193 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1110693001194 active site 1110693001195 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1110693001196 catalytic triad [active] 1110693001197 dimer interface [polypeptide binding]; other site 1110693001198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1110693001199 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1110693001200 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1110693001201 DNA binding site [nucleotide binding] 1110693001202 active site 1110693001203 Uncharacterized conserved protein [Function unknown]; Region: COG5507 1110693001204 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1110693001205 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1110693001206 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1110693001207 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1110693001208 maltose O-acetyltransferase; Provisional; Region: PRK10092 1110693001209 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1110693001210 active site 1110693001211 substrate binding site [chemical binding]; other site 1110693001212 trimer interface [polypeptide binding]; other site 1110693001213 CoA binding site [chemical binding]; other site 1110693001214 gene expression modulator; Provisional; Region: PRK10945 1110693001215 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 1110693001216 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1110693001217 Protein export membrane protein; Region: SecD_SecF; cl14618 1110693001218 Protein export membrane protein; Region: SecD_SecF; cl14618 1110693001219 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1110693001220 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693001221 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693001222 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1110693001223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1110693001224 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1110693001225 hypothetical protein; Provisional; Region: PRK11281 1110693001226 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1110693001227 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1110693001228 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1110693001229 hypothetical protein; Provisional; Region: PRK11038 1110693001230 primosomal replication protein N''; Provisional; Region: PRK10093 1110693001231 hypothetical protein; Provisional; Region: PRK10527 1110693001232 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1110693001233 active site 1110693001234 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1110693001235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693001236 Walker A motif; other site 1110693001237 ATP binding site [chemical binding]; other site 1110693001238 Walker B motif; other site 1110693001239 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1110693001240 arginine finger; other site 1110693001241 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1110693001242 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1110693001243 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1110693001244 hypothetical protein; Validated; Region: PRK00153 1110693001245 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 1110693001246 RecR protein; Region: RecR; pfam02132 1110693001247 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1110693001248 putative active site [active] 1110693001249 putative metal-binding site [ion binding]; other site 1110693001250 tetramer interface [polypeptide binding]; other site 1110693001251 heat shock protein 90; Provisional; Region: PRK05218 1110693001252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693001253 ATP binding site [chemical binding]; other site 1110693001254 Mg2+ binding site [ion binding]; other site 1110693001255 G-X-G motif; other site 1110693001256 adenylate kinase; Reviewed; Region: adk; PRK00279 1110693001257 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1110693001258 AMP-binding site [chemical binding]; other site 1110693001259 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1110693001260 ferrochelatase; Region: hemH; TIGR00109 1110693001261 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1110693001262 C-terminal domain interface [polypeptide binding]; other site 1110693001263 active site 1110693001264 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1110693001265 active site 1110693001266 N-terminal domain interface [polypeptide binding]; other site 1110693001267 acetyl esterase; Provisional; Region: PRK10162 1110693001268 inosine/guanosine kinase; Provisional; Region: PRK15074 1110693001269 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1110693001270 putative cation:proton antiport protein; Provisional; Region: PRK10669 1110693001271 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1110693001272 TrkA-N domain; Region: TrkA_N; pfam02254 1110693001273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693001274 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1110693001275 putative substrate translocation pore; other site 1110693001276 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1110693001277 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1110693001278 active site 1110693001279 metal binding site [ion binding]; metal-binding site 1110693001280 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1110693001281 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1110693001282 putative deacylase active site [active] 1110693001283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1110693001284 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1110693001285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1110693001286 non-specific DNA binding site [nucleotide binding]; other site 1110693001287 salt bridge; other site 1110693001288 sequence-specific DNA binding site [nucleotide binding]; other site 1110693001289 copper exporting ATPase; Provisional; Region: copA; PRK10671 1110693001290 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1110693001291 metal-binding site [ion binding] 1110693001292 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1110693001293 metal-binding site [ion binding] 1110693001294 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1110693001295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693001296 motif II; other site 1110693001297 glutaminase; Reviewed; Region: PRK12356 1110693001298 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1110693001299 amino acid transporter; Region: 2A0306; TIGR00909 1110693001300 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1110693001301 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1110693001302 DNA binding residues [nucleotide binding] 1110693001303 dimer interface [polypeptide binding]; other site 1110693001304 copper binding site [ion binding]; other site 1110693001305 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1110693001306 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1110693001307 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1110693001308 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1110693001309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693001310 Walker A/P-loop; other site 1110693001311 ATP binding site [chemical binding]; other site 1110693001312 Q-loop/lid; other site 1110693001313 ABC transporter signature motif; other site 1110693001314 Walker B; other site 1110693001315 D-loop; other site 1110693001316 H-loop/switch region; other site 1110693001317 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 1110693001318 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1110693001319 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1110693001320 oxidoreductase; Provisional; Region: PRK08017 1110693001321 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1110693001322 NADP binding site [chemical binding]; other site 1110693001323 active site 1110693001324 steroid binding site; other site 1110693001325 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1110693001326 active site 1110693001327 catalytic triad [active] 1110693001328 oxyanion hole [active] 1110693001329 switch loop; other site 1110693001330 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1110693001331 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1110693001332 Walker A/P-loop; other site 1110693001333 ATP binding site [chemical binding]; other site 1110693001334 Q-loop/lid; other site 1110693001335 ABC transporter signature motif; other site 1110693001336 Walker B; other site 1110693001337 D-loop; other site 1110693001338 H-loop/switch region; other site 1110693001339 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1110693001340 FtsX-like permease family; Region: FtsX; pfam02687 1110693001341 FtsX-like permease family; Region: FtsX; pfam02687 1110693001342 Predicted ATPase [General function prediction only]; Region: COG2603 1110693001343 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1110693001344 active site residue [active] 1110693001345 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1110693001346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693001347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1110693001348 dimerization interface [polypeptide binding]; other site 1110693001349 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1110693001350 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1110693001351 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 1110693001352 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1110693001353 Bacterial transcriptional regulator; Region: IclR; pfam01614 1110693001354 glyoxylate carboligase; Provisional; Region: PRK11269 1110693001355 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1110693001356 PYR/PP interface [polypeptide binding]; other site 1110693001357 dimer interface [polypeptide binding]; other site 1110693001358 TPP binding site [chemical binding]; other site 1110693001359 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1110693001360 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1110693001361 TPP-binding site [chemical binding]; other site 1110693001362 hydroxypyruvate isomerase; Provisional; Region: PRK09997 1110693001363 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1110693001364 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1110693001365 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 1110693001366 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1110693001367 Na binding site [ion binding]; other site 1110693001368 substrate binding site [chemical binding]; other site 1110693001369 allantoinase; Provisional; Region: PRK08044 1110693001370 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1110693001371 active site 1110693001372 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1110693001373 glycerate kinase II; Provisional; Region: PRK09932 1110693001374 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 1110693001375 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 1110693001376 Cupin domain; Region: Cupin_2; cl17218 1110693001377 allantoate amidohydrolase; Region: AllC; TIGR03176 1110693001378 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1110693001379 active site 1110693001380 metal binding site [ion binding]; metal-binding site 1110693001381 dimer interface [polypeptide binding]; other site 1110693001382 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 1110693001383 membrane protein FdrA; Validated; Region: PRK06091 1110693001384 CoA binding domain; Region: CoA_binding; pfam02629 1110693001385 CoA-ligase; Region: Ligase_CoA; pfam00549 1110693001386 predicted protein (pseudogene) 1110693001387 predicted protein, N-ter fragment (pseudogene) 1110693001388 predicted protein, C-ter fragment (pseudogene) 1110693001389 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1110693001390 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1110693001391 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1110693001392 putative substrate binding site [chemical binding]; other site 1110693001393 nucleotide binding site [chemical binding]; other site 1110693001394 nucleotide binding site [chemical binding]; other site 1110693001395 homodimer interface [polypeptide binding]; other site 1110693001396 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1110693001397 ATP-grasp domain; Region: ATP-grasp; pfam02222 1110693001398 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1110693001399 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1110693001400 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1110693001401 putative active site [active] 1110693001402 putative metal binding site [ion binding]; other site 1110693001403 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1110693001404 substrate binding site [chemical binding]; other site 1110693001405 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1110693001406 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1110693001407 active site 1110693001408 HIGH motif; other site 1110693001409 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1110693001410 KMSKS motif; other site 1110693001411 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1110693001412 tRNA binding surface [nucleotide binding]; other site 1110693001413 anticodon binding site; other site 1110693001414 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1110693001415 ribosome-associated protein; Provisional; Region: PRK11507 1110693001416 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1110693001417 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1110693001418 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1110693001419 homodimer interface [polypeptide binding]; other site 1110693001420 NADP binding site [chemical binding]; other site 1110693001421 substrate binding site [chemical binding]; other site 1110693001422 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 1110693001423 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1110693001424 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1110693001425 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1110693001426 outer membrane usher protein FimD; Provisional; Region: PRK15198 1110693001427 PapC N-terminal domain; Region: PapC_N; pfam13954 1110693001428 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1110693001429 PapC C-terminal domain; Region: PapC_C; pfam13953 1110693001430 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 1110693001431 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 1110693001432 transcriptional regulator FimZ; Provisional; Region: PRK09935 1110693001433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693001434 active site 1110693001435 phosphorylation site [posttranslational modification] 1110693001436 intermolecular recognition site; other site 1110693001437 dimerization interface [polypeptide binding]; other site 1110693001438 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693001439 DNA binding residues [nucleotide binding] 1110693001440 dimerization interface [polypeptide binding]; other site 1110693001441 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1110693001442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693001443 hypothetical protein; Provisional; Region: PRK09936 1110693001444 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 1110693001445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1110693001446 TPR motif; other site 1110693001447 binding surface 1110693001448 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 1110693001449 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 1110693001450 active site 1110693001451 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1110693001452 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1110693001453 sensor kinase CusS; Provisional; Region: PRK09835 1110693001454 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1110693001455 dimerization interface [polypeptide binding]; other site 1110693001456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693001457 dimer interface [polypeptide binding]; other site 1110693001458 phosphorylation site [posttranslational modification] 1110693001459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693001460 ATP binding site [chemical binding]; other site 1110693001461 Mg2+ binding site [ion binding]; other site 1110693001462 G-X-G motif; other site 1110693001463 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 1110693001464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693001465 active site 1110693001466 phosphorylation site [posttranslational modification] 1110693001467 intermolecular recognition site; other site 1110693001468 dimerization interface [polypeptide binding]; other site 1110693001469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693001470 DNA binding site [nucleotide binding] 1110693001471 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1110693001472 periplasmic copper-binding protein; Provisional; Region: PRK09838 1110693001473 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1110693001474 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693001475 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1110693001476 phenylalanine transporter; Provisional; Region: PRK10249 1110693001477 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1110693001478 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1110693001479 outer membrane receptor FepA; Provisional; Region: PRK13524 1110693001480 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1110693001481 N-terminal plug; other site 1110693001482 ligand-binding site [chemical binding]; other site 1110693001483 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1110693001484 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1110693001485 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1110693001486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1110693001487 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1110693001488 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1110693001489 acyl-activating enzyme (AAE) consensus motif; other site 1110693001490 AMP binding site [chemical binding]; other site 1110693001491 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1110693001492 LPS O-antigen length regulator; Provisional; Region: PRK10381 1110693001493 Chain length determinant protein; Region: Wzz; pfam02706 1110693001494 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1110693001495 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1110693001496 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1110693001497 Walker A/P-loop; other site 1110693001498 ATP binding site [chemical binding]; other site 1110693001499 Q-loop/lid; other site 1110693001500 ABC transporter signature motif; other site 1110693001501 Walker B; other site 1110693001502 D-loop; other site 1110693001503 H-loop/switch region; other site 1110693001504 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1110693001505 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1110693001506 ABC-ATPase subunit interface; other site 1110693001507 dimer interface [polypeptide binding]; other site 1110693001508 putative PBP binding regions; other site 1110693001509 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1110693001510 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1110693001511 ABC-ATPase subunit interface; other site 1110693001512 dimer interface [polypeptide binding]; other site 1110693001513 putative PBP binding regions; other site 1110693001514 enterobactin exporter EntS; Provisional; Region: PRK10489 1110693001515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693001516 putative substrate translocation pore; other site 1110693001517 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1110693001518 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1110693001519 siderophore binding site; other site 1110693001520 isochorismate synthase EntC; Provisional; Region: PRK15016 1110693001521 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1110693001522 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1110693001523 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1110693001524 acyl-activating enzyme (AAE) consensus motif; other site 1110693001525 active site 1110693001526 AMP binding site [chemical binding]; other site 1110693001527 substrate binding site [chemical binding]; other site 1110693001528 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1110693001529 hydrophobic substrate binding pocket; other site 1110693001530 Isochorismatase family; Region: Isochorismatase; pfam00857 1110693001531 active site 1110693001532 conserved cis-peptide bond; other site 1110693001533 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1110693001534 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1110693001535 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1110693001536 putative NAD(P) binding site [chemical binding]; other site 1110693001537 active site 1110693001538 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1110693001539 CoenzymeA binding site [chemical binding]; other site 1110693001540 subunit interaction site [polypeptide binding]; other site 1110693001541 PHB binding site; other site 1110693001542 carbon starvation protein A; Provisional; Region: PRK15015 1110693001543 Carbon starvation protein CstA; Region: CstA; pfam02554 1110693001544 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1110693001545 Uncharacterized small protein [Function unknown]; Region: COG2879 1110693001546 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1110693001547 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1110693001548 putative active site [active] 1110693001549 metal binding site [ion binding]; metal-binding site 1110693001550 methionine aminotransferase; Validated; Region: PRK09082 1110693001551 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1110693001552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693001553 homodimer interface [polypeptide binding]; other site 1110693001554 catalytic residue [active] 1110693001555 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1110693001556 ParB-like nuclease domain; Region: ParBc; pfam02195 1110693001557 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1110693001558 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1110693001559 Active Sites [active] 1110693001560 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1110693001561 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1110693001562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693001563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1110693001564 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1110693001565 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1110693001566 dimerization domain [polypeptide binding]; other site 1110693001567 dimer interface [polypeptide binding]; other site 1110693001568 catalytic residues [active] 1110693001569 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1110693001570 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1110693001571 dimer interface [polypeptide binding]; other site 1110693001572 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1110693001573 catalytic triad [active] 1110693001574 peroxidatic and resolving cysteines [active] 1110693001575 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1110693001576 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1110693001577 catalytic residue [active] 1110693001578 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1110693001579 catalytic residues [active] 1110693001580 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1110693001581 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693001582 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1110693001583 Ligand Binding Site [chemical binding]; other site 1110693001584 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1110693001585 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1110693001586 NAD binding site [chemical binding]; other site 1110693001587 catalytic Zn binding site [ion binding]; other site 1110693001588 structural Zn binding site [ion binding]; other site 1110693001589 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1110693001590 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1110693001591 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1110693001592 B1 nucleotide binding pocket [chemical binding]; other site 1110693001593 B2 nucleotide binding pocket [chemical binding]; other site 1110693001594 CAS motifs; other site 1110693001595 active site 1110693001596 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1110693001597 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1110693001598 transmembrane helices; other site 1110693001599 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 1110693001600 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1110693001601 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1110693001602 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1110693001603 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1110693001604 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1110693001605 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1110693001606 putative active site [active] 1110693001607 (T/H)XGH motif; other site 1110693001608 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1110693001609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1110693001610 putative active site [active] 1110693001611 heme pocket [chemical binding]; other site 1110693001612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693001613 ATP binding site [chemical binding]; other site 1110693001614 Mg2+ binding site [ion binding]; other site 1110693001615 G-X-G motif; other site 1110693001616 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1110693001617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693001618 active site 1110693001619 phosphorylation site [posttranslational modification] 1110693001620 intermolecular recognition site; other site 1110693001621 dimerization interface [polypeptide binding]; other site 1110693001622 Transcriptional regulator; Region: CitT; pfam12431 1110693001623 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1110693001624 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1110693001625 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1110693001626 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1110693001627 DNA-binding site [nucleotide binding]; DNA binding site 1110693001628 RNA-binding motif; other site 1110693001629 chromosome condensation membrane protein; Provisional; Region: PRK14196 1110693001630 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1110693001631 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1110693001632 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1110693001633 active site 1110693001634 catalytic triad [active] 1110693001635 dimer interface [polypeptide binding]; other site 1110693001636 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1110693001637 lipoyl synthase; Provisional; Region: PRK05481 1110693001638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693001639 FeS/SAM binding site; other site 1110693001640 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1110693001641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693001642 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1110693001643 substrate binding pocket [chemical binding]; other site 1110693001644 dimerization interface [polypeptide binding]; other site 1110693001645 lipoate-protein ligase B; Provisional; Region: PRK14342 1110693001646 hypothetical protein; Provisional; Region: PRK04998 1110693001647 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1110693001648 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1110693001649 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1110693001650 rare lipoprotein A; Provisional; Region: PRK10672 1110693001651 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1110693001652 Sporulation related domain; Region: SPOR; pfam05036 1110693001653 cell wall shape-determining protein; Provisional; Region: PRK10794 1110693001654 penicillin-binding protein 2; Provisional; Region: PRK10795 1110693001655 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1110693001656 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1110693001657 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1110693001658 ribosome-associated protein; Provisional; Region: PRK11538 1110693001659 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1110693001660 catalytic core [active] 1110693001661 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1110693001662 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1110693001663 active site 1110693001664 (T/H)XGH motif; other site 1110693001665 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1110693001666 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1110693001667 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1110693001668 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1110693001669 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1110693001670 HIGH motif; other site 1110693001671 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1110693001672 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1110693001673 active site 1110693001674 KMSKS motif; other site 1110693001675 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1110693001676 tRNA binding surface [nucleotide binding]; other site 1110693001677 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1110693001678 hypothetical protein; Provisional; Region: PRK11032 1110693001679 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1110693001680 Sel1-like repeats; Region: SEL1; smart00671 1110693001681 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1110693001682 Sel1-like repeats; Region: SEL1; smart00671 1110693001683 Sel1-like repeats; Region: SEL1; smart00671 1110693001684 Sel1-like repeats; Region: SEL1; smart00671 1110693001685 Sel1-like repeats; Region: SEL1; smart00671 1110693001686 Sel1-like repeats; Region: SEL1; smart00671 1110693001687 Sel1-like repeats; Region: SEL1; smart00671 1110693001688 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1110693001689 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1110693001690 HSP70 interaction site [polypeptide binding]; other site 1110693001691 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1110693001692 Sel1-like repeats; Region: SEL1; smart00671 1110693001693 Sel1-like repeats; Region: SEL1; smart00671 1110693001694 Sel1 repeat; Region: Sel1; cl02723 1110693001695 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1110693001696 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1110693001697 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1110693001698 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 1110693001699 nucleotide binding site [chemical binding]; other site 1110693001700 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1110693001701 SBD interface [polypeptide binding]; other site 1110693001702 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1110693001703 active site 1110693001704 tetramer interface [polypeptide binding]; other site 1110693001705 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1110693001706 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1110693001707 Walker A/P-loop; other site 1110693001708 ATP binding site [chemical binding]; other site 1110693001709 Q-loop/lid; other site 1110693001710 ABC transporter signature motif; other site 1110693001711 Walker B; other site 1110693001712 D-loop; other site 1110693001713 H-loop/switch region; other site 1110693001714 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1110693001715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693001716 dimer interface [polypeptide binding]; other site 1110693001717 conserved gate region; other site 1110693001718 putative PBP binding loops; other site 1110693001719 ABC-ATPase subunit interface; other site 1110693001720 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1110693001721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693001722 dimer interface [polypeptide binding]; other site 1110693001723 conserved gate region; other site 1110693001724 putative PBP binding loops; other site 1110693001725 ABC-ATPase subunit interface; other site 1110693001726 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1110693001727 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693001728 substrate binding pocket [chemical binding]; other site 1110693001729 membrane-bound complex binding site; other site 1110693001730 hinge residues; other site 1110693001731 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1110693001732 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1110693001733 putative active site [active] 1110693001734 catalytic triad [active] 1110693001735 putative dimer interface [polypeptide binding]; other site 1110693001736 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1110693001737 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1110693001738 Transporter associated domain; Region: CorC_HlyC; smart01091 1110693001739 metal-binding heat shock protein; Provisional; Region: PRK00016 1110693001740 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1110693001741 PhoH-like protein; Region: PhoH; pfam02562 1110693001742 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1110693001743 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1110693001744 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693001745 FeS/SAM binding site; other site 1110693001746 TRAM domain; Region: TRAM; pfam01938 1110693001747 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1110693001748 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1110693001749 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1110693001750 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1110693001751 active site 1110693001752 dimer interface [polypeptide binding]; other site 1110693001753 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1110693001754 Ligand Binding Site [chemical binding]; other site 1110693001755 Molecular Tunnel; other site 1110693001756 UMP phosphatase; Provisional; Region: PRK10444 1110693001757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693001758 active site 1110693001759 motif I; other site 1110693001760 motif II; other site 1110693001761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693001762 MarR family; Region: MarR; pfam01047 1110693001763 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1110693001764 ROK family; Region: ROK; pfam00480 1110693001765 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1110693001766 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1110693001767 active site 1110693001768 dimer interface [polypeptide binding]; other site 1110693001769 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1110693001770 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1110693001771 active site 1110693001772 trimer interface [polypeptide binding]; other site 1110693001773 allosteric site; other site 1110693001774 active site lid [active] 1110693001775 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1110693001776 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1110693001777 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1110693001778 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1110693001779 active site turn [active] 1110693001780 phosphorylation site [posttranslational modification] 1110693001781 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1110693001782 HPr interaction site; other site 1110693001783 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1110693001784 active site 1110693001785 phosphorylation site [posttranslational modification] 1110693001786 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1110693001787 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1110693001788 active site 1110693001789 HIGH motif; other site 1110693001790 nucleotide binding site [chemical binding]; other site 1110693001791 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1110693001792 KMSKS motif; other site 1110693001793 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1110693001794 outer membrane porin, OprD family; Region: OprD; pfam03573 1110693001795 YbfN-like lipoprotein; Region: YbfN; pfam13982 1110693001796 ferric uptake regulator; Provisional; Region: fur; PRK09462 1110693001797 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1110693001798 metal binding site 2 [ion binding]; metal-binding site 1110693001799 putative DNA binding helix; other site 1110693001800 metal binding site 1 [ion binding]; metal-binding site 1110693001801 dimer interface [polypeptide binding]; other site 1110693001802 structural Zn2+ binding site [ion binding]; other site 1110693001803 flavodoxin FldA; Validated; Region: PRK09267 1110693001804 LexA regulated protein; Provisional; Region: PRK11675 1110693001805 acyl-CoA esterase; Provisional; Region: PRK10673 1110693001806 PGAP1-like protein; Region: PGAP1; pfam07819 1110693001807 replication initiation regulator SeqA; Provisional; Region: PRK11187 1110693001808 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1110693001809 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1110693001810 active site 1110693001811 substrate binding site [chemical binding]; other site 1110693001812 metal binding site [ion binding]; metal-binding site 1110693001813 Protein of unknown function DUF2625; Region: DUF2625; cl08177 1110693001814 Protein of unknown function DUF2625; Region: DUF2625; cl08177 1110693001815 putrescine transporter; Provisional; Region: potE; PRK10655 1110693001816 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1110693001817 ornithine decarboxylase; Provisional; Region: PRK13578 1110693001818 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1110693001819 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1110693001820 homodimer interface [polypeptide binding]; other site 1110693001821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693001822 catalytic residue [active] 1110693001823 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1110693001824 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1110693001825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693001826 active site 1110693001827 phosphorylation site [posttranslational modification] 1110693001828 intermolecular recognition site; other site 1110693001829 dimerization interface [polypeptide binding]; other site 1110693001830 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693001831 DNA binding site [nucleotide binding] 1110693001832 sensor protein KdpD; Provisional; Region: PRK10490 1110693001833 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1110693001834 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1110693001835 Ligand Binding Site [chemical binding]; other site 1110693001836 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1110693001837 GAF domain; Region: GAF_3; pfam13492 1110693001838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693001839 dimer interface [polypeptide binding]; other site 1110693001840 phosphorylation site [posttranslational modification] 1110693001841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693001842 ATP binding site [chemical binding]; other site 1110693001843 Mg2+ binding site [ion binding]; other site 1110693001844 G-X-G motif; other site 1110693001845 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1110693001846 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1110693001847 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1110693001848 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1110693001849 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1110693001850 hypothetical protein; Provisional; Region: PRK10167 1110693001851 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1110693001852 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1110693001853 DNA photolyase; Region: DNA_photolyase; pfam00875 1110693001854 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1110693001855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693001856 putative substrate translocation pore; other site 1110693001857 POT family; Region: PTR2; pfam00854 1110693001858 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1110693001859 metal-binding protein; Provisional; Region: PRK10799 1110693001860 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1110693001861 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 1110693001862 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 1110693001863 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1110693001864 putative active site [active] 1110693001865 endonuclease VIII; Provisional; Region: PRK10445 1110693001866 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1110693001867 DNA binding site [nucleotide binding] 1110693001868 catalytic residue [active] 1110693001869 putative catalytic residues [active] 1110693001870 H2TH interface [polypeptide binding]; other site 1110693001871 intercalation triad [nucleotide binding]; other site 1110693001872 substrate specificity determining residue; other site 1110693001873 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1110693001874 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1110693001875 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1110693001876 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1110693001877 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1110693001878 Fimbrial protein; Region: Fimbrial; pfam00419 1110693001879 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1110693001880 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1110693001881 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1110693001882 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1110693001883 PapC N-terminal domain; Region: PapC_N; pfam13954 1110693001884 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1110693001885 PapC C-terminal domain; Region: PapC_C; pfam13953 1110693001886 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1110693001887 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1110693001888 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1110693001889 dimer interface [polypeptide binding]; other site 1110693001890 active site 1110693001891 citrylCoA binding site [chemical binding]; other site 1110693001892 NADH binding [chemical binding]; other site 1110693001893 cationic pore residues; other site 1110693001894 oxalacetate/citrate binding site [chemical binding]; other site 1110693001895 coenzyme A binding site [chemical binding]; other site 1110693001896 catalytic triad [active] 1110693001897 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1110693001898 Iron-sulfur protein interface; other site 1110693001899 proximal quinone binding site [chemical binding]; other site 1110693001900 SdhD (CybS) interface [polypeptide binding]; other site 1110693001901 proximal heme binding site [chemical binding]; other site 1110693001902 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1110693001903 SdhC subunit interface [polypeptide binding]; other site 1110693001904 proximal heme binding site [chemical binding]; other site 1110693001905 cardiolipin binding site; other site 1110693001906 Iron-sulfur protein interface; other site 1110693001907 proximal quinone binding site [chemical binding]; other site 1110693001908 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1110693001909 L-aspartate oxidase; Provisional; Region: PRK06175 1110693001910 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1110693001911 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1110693001912 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1110693001913 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1110693001914 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1110693001915 TPP-binding site [chemical binding]; other site 1110693001916 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1110693001917 dimer interface [polypeptide binding]; other site 1110693001918 PYR/PP interface [polypeptide binding]; other site 1110693001919 TPP binding site [chemical binding]; other site 1110693001920 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1110693001921 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1110693001922 E3 interaction surface; other site 1110693001923 lipoyl attachment site [posttranslational modification]; other site 1110693001924 e3 binding domain; Region: E3_binding; pfam02817 1110693001925 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1110693001926 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1110693001927 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1110693001928 CoA-ligase; Region: Ligase_CoA; pfam00549 1110693001929 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1110693001930 CoA binding domain; Region: CoA_binding; smart00881 1110693001931 CoA-ligase; Region: Ligase_CoA; pfam00549 1110693001932 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 1110693001933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693001934 DNA-binding site [nucleotide binding]; DNA binding site 1110693001935 UTRA domain; Region: UTRA; pfam07702 1110693001936 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1110693001937 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1110693001938 active site 1110693001939 phosphorylation site [posttranslational modification] 1110693001940 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1110693001941 active site 1110693001942 P-loop; other site 1110693001943 phosphorylation site [posttranslational modification] 1110693001944 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1110693001945 alpha-mannosidase; Provisional; Region: PRK09819 1110693001946 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1110693001947 active site 1110693001948 metal binding site [ion binding]; metal-binding site 1110693001949 catalytic site [active] 1110693001950 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1110693001951 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1110693001952 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1110693001953 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1110693001954 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1110693001955 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1110693001956 hypothetical protein; Provisional; Region: PRK10588 1110693001957 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1110693001958 active site 1110693001959 colicin uptake protein TolQ; Provisional; Region: PRK10801 1110693001960 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1110693001961 colicin uptake protein TolR; Provisional; Region: PRK11024 1110693001962 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1110693001963 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1110693001964 TolA C-terminal; Region: TolA; pfam06519 1110693001965 translocation protein TolB; Provisional; Region: tolB; PRK03629 1110693001966 TolB amino-terminal domain; Region: TolB_N; pfam04052 1110693001967 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1110693001968 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1110693001969 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1110693001970 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1110693001971 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1110693001972 ligand binding site [chemical binding]; other site 1110693001973 tol-pal system protein YbgF; Provisional; Region: PRK10803 1110693001974 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1110693001975 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1110693001976 quinolinate synthetase; Provisional; Region: PRK09375 1110693001977 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1110693001978 zinc transporter ZitB; Provisional; Region: PRK03557 1110693001979 YbgS-like protein; Region: YbgS; pfam13985 1110693001980 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1110693001981 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1110693001982 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1110693001983 catalytic core [active] 1110693001984 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1110693001985 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1110693001986 active site 1110693001987 catalytic residues [active] 1110693001988 galactokinase; Provisional; Region: PRK05101 1110693001989 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1110693001990 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1110693001991 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1110693001992 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1110693001993 dimer interface [polypeptide binding]; other site 1110693001994 active site 1110693001995 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1110693001996 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1110693001997 NAD binding site [chemical binding]; other site 1110693001998 homodimer interface [polypeptide binding]; other site 1110693001999 active site 1110693002000 substrate binding site [chemical binding]; other site 1110693002001 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1110693002002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1110693002003 Walker A/P-loop; other site 1110693002004 ATP binding site [chemical binding]; other site 1110693002005 Q-loop/lid; other site 1110693002006 ABC transporter signature motif; other site 1110693002007 Walker B; other site 1110693002008 D-loop; other site 1110693002009 H-loop/switch region; other site 1110693002010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693002011 Walker A/P-loop; other site 1110693002012 ATP binding site [chemical binding]; other site 1110693002013 Q-loop/lid; other site 1110693002014 ABC transporter signature motif; other site 1110693002015 Walker B; other site 1110693002016 D-loop; other site 1110693002017 H-loop/switch region; other site 1110693002018 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1110693002019 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1110693002020 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1110693002021 TOBE domain; Region: TOBE; pfam03459 1110693002022 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1110693002023 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1110693002024 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693002025 substrate binding pocket [chemical binding]; other site 1110693002026 membrane-bound complex binding site; other site 1110693002027 hinge residues; other site 1110693002028 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1110693002029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693002030 putative PBP binding loops; other site 1110693002031 ABC-ATPase subunit interface; other site 1110693002032 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1110693002033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693002034 Walker A/P-loop; other site 1110693002035 ATP binding site [chemical binding]; other site 1110693002036 Q-loop/lid; other site 1110693002037 ABC transporter signature motif; other site 1110693002038 Walker B; other site 1110693002039 D-loop; other site 1110693002040 H-loop/switch region; other site 1110693002041 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1110693002042 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1110693002043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693002044 motif II; other site 1110693002045 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693002046 6-phosphogluconolactonase; Provisional; Region: PRK11028 1110693002047 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1110693002048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693002049 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1110693002050 putative dimerization interface [polypeptide binding]; other site 1110693002051 PrpF protein; Region: PrpF; pfam04303 1110693002052 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1110693002053 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1110693002054 transmembrane helices; other site 1110693002055 putative hydratase; Provisional; Region: PRK11413 1110693002056 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1110693002057 substrate binding site [chemical binding]; other site 1110693002058 ligand binding site [chemical binding]; other site 1110693002059 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1110693002060 substrate binding site [chemical binding]; other site 1110693002061 acyl-CoA thioesterase; Provisional; Region: PRK10531 1110693002062 putative pectinesterase; Region: PLN02432; cl01911 1110693002063 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1110693002064 substrate binding site [chemical binding]; other site 1110693002065 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1110693002066 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1110693002067 inhibitor-cofactor binding pocket; inhibition site 1110693002068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693002069 catalytic residue [active] 1110693002070 biotin synthase; Provisional; Region: PRK15108 1110693002071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693002072 FeS/SAM binding site; other site 1110693002073 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1110693002074 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1110693002075 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1110693002076 substrate-cofactor binding pocket; other site 1110693002077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693002078 catalytic residue [active] 1110693002079 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1110693002080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693002081 S-adenosylmethionine binding site [chemical binding]; other site 1110693002082 AAA domain; Region: AAA_26; pfam13500 1110693002083 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1110693002084 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1110693002085 ADP binding site [chemical binding]; other site 1110693002086 excinuclease ABC subunit B; Provisional; Region: PRK05298 1110693002087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1110693002088 ATP binding site [chemical binding]; other site 1110693002089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1110693002090 nucleotide binding region [chemical binding]; other site 1110693002091 ATP-binding site [chemical binding]; other site 1110693002092 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1110693002093 UvrB/uvrC motif; Region: UVR; pfam02151 1110693002094 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1110693002095 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1110693002096 putative substrate binding pocket [chemical binding]; other site 1110693002097 dimer interface [polypeptide binding]; other site 1110693002098 phosphate binding site [ion binding]; other site 1110693002099 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1110693002100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693002101 FeS/SAM binding site; other site 1110693002102 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1110693002103 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1110693002104 MPT binding site; other site 1110693002105 trimer interface [polypeptide binding]; other site 1110693002106 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1110693002107 trimer interface [polypeptide binding]; other site 1110693002108 dimer interface [polypeptide binding]; other site 1110693002109 putative active site [active] 1110693002110 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1110693002111 MoaE interaction surface [polypeptide binding]; other site 1110693002112 MoeB interaction surface [polypeptide binding]; other site 1110693002113 thiocarboxylated glycine; other site 1110693002114 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1110693002115 MoaE homodimer interface [polypeptide binding]; other site 1110693002116 MoaD interaction [polypeptide binding]; other site 1110693002117 active site residues [active] 1110693002118 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1110693002119 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1110693002120 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1110693002121 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1110693002122 Predicted integral membrane protein [Function unknown]; Region: COG0392 1110693002123 cardiolipin synthase 2; Provisional; Region: PRK11263 1110693002124 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1110693002125 putative active site [active] 1110693002126 catalytic site [active] 1110693002127 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1110693002128 putative active site [active] 1110693002129 catalytic site [active] 1110693002130 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1110693002131 putative catalytic site [active] 1110693002132 putative metal binding site [ion binding]; other site 1110693002133 putative phosphate binding site [ion binding]; other site 1110693002134 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1110693002135 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1110693002136 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1110693002137 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1110693002138 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1110693002139 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1110693002140 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1110693002141 Walker A/P-loop; other site 1110693002142 ATP binding site [chemical binding]; other site 1110693002143 Q-loop/lid; other site 1110693002144 ABC transporter signature motif; other site 1110693002145 Walker B; other site 1110693002146 D-loop; other site 1110693002147 H-loop/switch region; other site 1110693002148 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1110693002149 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1110693002150 Walker A/P-loop; other site 1110693002151 ATP binding site [chemical binding]; other site 1110693002152 Q-loop/lid; other site 1110693002153 ABC transporter signature motif; other site 1110693002154 Walker B; other site 1110693002155 D-loop; other site 1110693002156 H-loop/switch region; other site 1110693002157 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1110693002158 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693002159 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693002160 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1110693002161 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1110693002162 helicase 45; Provisional; Region: PTZ00424 1110693002163 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1110693002164 ATP binding site [chemical binding]; other site 1110693002165 Mg++ binding site [ion binding]; other site 1110693002166 motif III; other site 1110693002167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1110693002168 nucleotide binding region [chemical binding]; other site 1110693002169 ATP-binding site [chemical binding]; other site 1110693002170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 1110693002171 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1110693002172 DEAD_2; Region: DEAD_2; pfam06733 1110693002173 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1110693002174 glycosyl transferase family protein; Provisional; Region: PRK08136 1110693002175 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1110693002176 putative dehydrogenase; Provisional; Region: PRK10098 1110693002177 hypothetical protein; Provisional; Region: PRK10259 1110693002178 hypothetical protein; Provisional; Region: PRK11019 1110693002179 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1110693002180 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 1110693002181 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1110693002182 N-terminal plug; other site 1110693002183 ligand-binding site [chemical binding]; other site 1110693002184 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1110693002185 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1110693002186 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1110693002187 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1110693002188 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1110693002189 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1110693002190 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1110693002191 Walker A/P-loop; other site 1110693002192 ATP binding site [chemical binding]; other site 1110693002193 Q-loop/lid; other site 1110693002194 ABC transporter signature motif; other site 1110693002195 Walker B; other site 1110693002196 D-loop; other site 1110693002197 H-loop/switch region; other site 1110693002198 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1110693002199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693002200 dimer interface [polypeptide binding]; other site 1110693002201 conserved gate region; other site 1110693002202 putative PBP binding loops; other site 1110693002203 ABC-ATPase subunit interface; other site 1110693002204 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1110693002205 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693002206 substrate binding pocket [chemical binding]; other site 1110693002207 membrane-bound complex binding site; other site 1110693002208 hinge residues; other site 1110693002209 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1110693002210 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1110693002211 dimerization interface [polypeptide binding]; other site 1110693002212 DPS ferroxidase diiron center [ion binding]; other site 1110693002213 ion pore; other site 1110693002214 threonine and homoserine efflux system; Provisional; Region: PRK10532 1110693002215 EamA-like transporter family; Region: EamA; pfam00892 1110693002216 outer membrane protein X; Provisional; Region: ompX; PRK09408 1110693002217 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1110693002218 Sulfatase; Region: Sulfatase; pfam00884 1110693002219 manganese transport regulator MntR; Provisional; Region: PRK11050 1110693002220 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1110693002221 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1110693002222 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1110693002223 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1110693002224 transmembrane helices; other site 1110693002225 L,D-transpeptidase; Provisional; Region: PRK10260 1110693002226 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1110693002227 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1110693002228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693002229 Walker A/P-loop; other site 1110693002230 ATP binding site [chemical binding]; other site 1110693002231 Q-loop/lid; other site 1110693002232 ABC transporter signature motif; other site 1110693002233 Walker B; other site 1110693002234 D-loop; other site 1110693002235 H-loop/switch region; other site 1110693002236 ABC transporter; Region: ABC_tran_2; pfam12848 1110693002237 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1110693002238 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1110693002239 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1110693002240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693002241 active site 1110693002242 motif I; other site 1110693002243 motif II; other site 1110693002244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693002245 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1110693002246 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1110693002247 dimer interface [polypeptide binding]; other site 1110693002248 active site 1110693002249 glycine loop; other site 1110693002250 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1110693002251 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1110693002252 active site 1110693002253 intersubunit interactions; other site 1110693002254 catalytic residue [active] 1110693002255 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1110693002256 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1110693002257 ATP binding site [chemical binding]; other site 1110693002258 substrate interface [chemical binding]; other site 1110693002259 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1110693002260 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1110693002261 dimer interface [polypeptide binding]; other site 1110693002262 putative functional site; other site 1110693002263 putative MPT binding site; other site 1110693002264 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1110693002265 catalytic nucleophile [active] 1110693002266 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1110693002267 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693002268 Walker A/P-loop; other site 1110693002269 ATP binding site [chemical binding]; other site 1110693002270 Q-loop/lid; other site 1110693002271 ABC transporter signature motif; other site 1110693002272 Walker B; other site 1110693002273 D-loop; other site 1110693002274 H-loop/switch region; other site 1110693002275 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1110693002276 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693002277 Walker A/P-loop; other site 1110693002278 ATP binding site [chemical binding]; other site 1110693002279 Q-loop/lid; other site 1110693002280 ABC transporter signature motif; other site 1110693002281 Walker B; other site 1110693002282 D-loop; other site 1110693002283 H-loop/switch region; other site 1110693002284 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1110693002285 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1110693002286 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1110693002287 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1110693002288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693002289 dimer interface [polypeptide binding]; other site 1110693002290 conserved gate region; other site 1110693002291 putative PBP binding loops; other site 1110693002292 ABC-ATPase subunit interface; other site 1110693002293 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1110693002294 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1110693002295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693002296 dimer interface [polypeptide binding]; other site 1110693002297 conserved gate region; other site 1110693002298 putative PBP binding loops; other site 1110693002299 ABC-ATPase subunit interface; other site 1110693002300 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1110693002301 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1110693002302 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693002303 metal binding site [ion binding]; metal-binding site 1110693002304 active site 1110693002305 I-site; other site 1110693002306 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1110693002307 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1110693002308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693002309 FeS/SAM binding site; other site 1110693002310 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1110693002311 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1110693002312 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1110693002313 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1110693002314 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1110693002315 putative C-terminal domain interface [polypeptide binding]; other site 1110693002316 putative GSH binding site (G-site) [chemical binding]; other site 1110693002317 putative dimer interface [polypeptide binding]; other site 1110693002318 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1110693002319 N-terminal domain interface [polypeptide binding]; other site 1110693002320 dimer interface [polypeptide binding]; other site 1110693002321 substrate binding pocket (H-site) [chemical binding]; other site 1110693002322 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1110693002323 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1110693002324 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1110693002325 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1110693002326 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1110693002327 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1110693002328 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1110693002329 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1110693002330 active site 1110693002331 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1110693002332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693002333 putative substrate translocation pore; other site 1110693002334 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1110693002335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693002336 active site 1110693002337 motif I; other site 1110693002338 motif II; other site 1110693002339 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693002340 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1110693002341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693002342 putative substrate translocation pore; other site 1110693002343 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1110693002344 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1110693002345 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1110693002346 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1110693002347 putative transporter; Provisional; Region: PRK04972 1110693002348 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1110693002349 TrkA-C domain; Region: TrkA_C; pfam02080 1110693002350 TrkA-C domain; Region: TrkA_C; pfam02080 1110693002351 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1110693002352 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1110693002353 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1110693002354 GSH binding site [chemical binding]; other site 1110693002355 catalytic residues [active] 1110693002356 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1110693002357 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1110693002358 dimer interface [polypeptide binding]; other site 1110693002359 FMN binding site [chemical binding]; other site 1110693002360 NADPH bind site [chemical binding]; other site 1110693002361 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1110693002362 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1110693002363 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1110693002364 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1110693002365 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1110693002366 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1110693002367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693002368 Walker A/P-loop; other site 1110693002369 ATP binding site [chemical binding]; other site 1110693002370 Q-loop/lid; other site 1110693002371 ABC transporter signature motif; other site 1110693002372 Walker B; other site 1110693002373 D-loop; other site 1110693002374 H-loop/switch region; other site 1110693002375 TOBE domain; Region: TOBE_2; pfam08402 1110693002376 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1110693002377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693002378 dimer interface [polypeptide binding]; other site 1110693002379 conserved gate region; other site 1110693002380 putative PBP binding loops; other site 1110693002381 ABC-ATPase subunit interface; other site 1110693002382 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1110693002383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693002384 dimer interface [polypeptide binding]; other site 1110693002385 conserved gate region; other site 1110693002386 putative PBP binding loops; other site 1110693002387 ABC-ATPase subunit interface; other site 1110693002388 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1110693002389 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1110693002390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693002391 S-adenosylmethionine binding site [chemical binding]; other site 1110693002392 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1110693002393 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693002394 substrate binding pocket [chemical binding]; other site 1110693002395 membrane-bound complex binding site; other site 1110693002396 hinge residues; other site 1110693002397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693002398 dimer interface [polypeptide binding]; other site 1110693002399 conserved gate region; other site 1110693002400 putative PBP binding loops; other site 1110693002401 ABC-ATPase subunit interface; other site 1110693002402 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1110693002403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693002404 dimer interface [polypeptide binding]; other site 1110693002405 conserved gate region; other site 1110693002406 putative PBP binding loops; other site 1110693002407 ABC-ATPase subunit interface; other site 1110693002408 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1110693002409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693002410 substrate binding pocket [chemical binding]; other site 1110693002411 membrane-bound complex binding site; other site 1110693002412 hinge residues; other site 1110693002413 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1110693002414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693002415 Walker A/P-loop; other site 1110693002416 ATP binding site [chemical binding]; other site 1110693002417 Q-loop/lid; other site 1110693002418 ABC transporter signature motif; other site 1110693002419 Walker B; other site 1110693002420 D-loop; other site 1110693002421 H-loop/switch region; other site 1110693002422 putative lipoprotein; Provisional; Region: PRK10533 1110693002423 hypothetical protein; Provisional; Region: PRK02877 1110693002424 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1110693002425 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1110693002426 amidase catalytic site [active] 1110693002427 Zn binding residues [ion binding]; other site 1110693002428 substrate binding site [chemical binding]; other site 1110693002429 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1110693002430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1110693002431 NAD(P) binding site [chemical binding]; other site 1110693002432 active site 1110693002433 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1110693002434 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1110693002435 putative NAD(P) binding site [chemical binding]; other site 1110693002436 putative active site [active] 1110693002437 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1110693002438 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1110693002439 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1110693002440 tetramer interface [polypeptide binding]; other site 1110693002441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693002442 catalytic residue [active] 1110693002443 pyruvate dehydrogenase; Provisional; Region: PRK09124 1110693002444 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1110693002445 PYR/PP interface [polypeptide binding]; other site 1110693002446 dimer interface [polypeptide binding]; other site 1110693002447 tetramer interface [polypeptide binding]; other site 1110693002448 TPP binding site [chemical binding]; other site 1110693002449 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1110693002450 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1110693002451 TPP-binding site [chemical binding]; other site 1110693002452 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1110693002453 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1110693002454 FAD binding pocket [chemical binding]; other site 1110693002455 FAD binding motif [chemical binding]; other site 1110693002456 phosphate binding motif [ion binding]; other site 1110693002457 beta-alpha-beta structure motif; other site 1110693002458 NAD binding pocket [chemical binding]; other site 1110693002459 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1110693002460 catalytic loop [active] 1110693002461 iron binding site [ion binding]; other site 1110693002462 hybrid cluster protein; Provisional; Region: PRK05290 1110693002463 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1110693002464 ACS interaction site; other site 1110693002465 CODH interaction site; other site 1110693002466 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1110693002467 hybrid metal cluster; other site 1110693002468 Predicted membrane protein [Function unknown]; Region: COG2431 1110693002469 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1110693002470 amphipathic channel; other site 1110693002471 Asn-Pro-Ala signature motifs; other site 1110693002472 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1110693002473 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1110693002474 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1110693002475 putative active site [active] 1110693002476 putative metal-binding site [ion binding]; other site 1110693002477 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1110693002478 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1110693002479 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693002480 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693002481 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1110693002482 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1110693002483 Walker A/P-loop; other site 1110693002484 ATP binding site [chemical binding]; other site 1110693002485 Q-loop/lid; other site 1110693002486 ABC transporter signature motif; other site 1110693002487 Walker B; other site 1110693002488 D-loop; other site 1110693002489 H-loop/switch region; other site 1110693002490 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1110693002491 FtsX-like permease family; Region: FtsX; pfam02687 1110693002492 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1110693002493 DNA-binding site [nucleotide binding]; DNA binding site 1110693002494 RNA-binding motif; other site 1110693002495 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1110693002496 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1110693002497 Clp amino terminal domain; Region: Clp_N; pfam02861 1110693002498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693002499 Walker A motif; other site 1110693002500 ATP binding site [chemical binding]; other site 1110693002501 Walker B motif; other site 1110693002502 arginine finger; other site 1110693002503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693002504 Walker A motif; other site 1110693002505 ATP binding site [chemical binding]; other site 1110693002506 Walker B motif; other site 1110693002507 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1110693002508 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1110693002509 rRNA binding site [nucleotide binding]; other site 1110693002510 predicted 30S ribosome binding site; other site 1110693002511 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1110693002512 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1110693002513 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1110693002514 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1110693002515 Walker A/P-loop; other site 1110693002516 ATP binding site [chemical binding]; other site 1110693002517 Q-loop/lid; other site 1110693002518 ABC transporter signature motif; other site 1110693002519 Walker B; other site 1110693002520 D-loop; other site 1110693002521 H-loop/switch region; other site 1110693002522 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1110693002523 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1110693002524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693002525 Walker A/P-loop; other site 1110693002526 ATP binding site [chemical binding]; other site 1110693002527 Q-loop/lid; other site 1110693002528 ABC transporter signature motif; other site 1110693002529 Walker B; other site 1110693002530 D-loop; other site 1110693002531 H-loop/switch region; other site 1110693002532 thioredoxin reductase; Provisional; Region: PRK10262 1110693002533 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1110693002534 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693002535 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1110693002536 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1110693002537 putative DNA binding site [nucleotide binding]; other site 1110693002538 putative Zn2+ binding site [ion binding]; other site 1110693002539 AsnC family; Region: AsnC_trans_reg; pfam01037 1110693002540 DNA translocase FtsK; Provisional; Region: PRK10263 1110693002541 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1110693002542 DNA translocase FtsK; Provisional; Region: PRK10263 1110693002543 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1110693002544 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1110693002545 periplasmic chaperone LolA; Region: lolA; TIGR00547 1110693002546 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1110693002547 recombination factor protein RarA; Reviewed; Region: PRK13342 1110693002548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693002549 Walker A motif; other site 1110693002550 ATP binding site [chemical binding]; other site 1110693002551 Walker B motif; other site 1110693002552 arginine finger; other site 1110693002553 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1110693002554 seryl-tRNA synthetase; Provisional; Region: PRK05431 1110693002555 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1110693002556 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1110693002557 dimer interface [polypeptide binding]; other site 1110693002558 active site 1110693002559 motif 1; other site 1110693002560 motif 2; other site 1110693002561 motif 3; other site 1110693002562 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1110693002563 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1110693002564 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1110693002565 putative [Fe4-S4] binding site [ion binding]; other site 1110693002566 putative molybdopterin cofactor binding site [chemical binding]; other site 1110693002567 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1110693002568 putative molybdopterin cofactor binding site; other site 1110693002569 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1110693002570 4Fe-4S binding domain; Region: Fer4; pfam00037 1110693002571 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1110693002572 Isochorismatase family; Region: Isochorismatase; pfam00857 1110693002573 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1110693002574 catalytic triad [active] 1110693002575 dimer interface [polypeptide binding]; other site 1110693002576 conserved cis-peptide bond; other site 1110693002577 putative MFS family transporter protein; Provisional; Region: PRK03633 1110693002578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693002579 putative substrate translocation pore; other site 1110693002580 Amino acid permease; Region: AA_permease_2; pfam13520 1110693002581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1110693002582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693002583 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1110693002584 putative effector binding pocket; other site 1110693002585 putative dimerization interface [polypeptide binding]; other site 1110693002586 hypothetical protein; Provisional; Region: PRK09739 1110693002587 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1110693002588 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1110693002589 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693002590 FeS/SAM binding site; other site 1110693002591 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1110693002592 Pyruvate formate lyase 1; Region: PFL1; cd01678 1110693002593 coenzyme A binding site [chemical binding]; other site 1110693002594 active site 1110693002595 catalytic residues [active] 1110693002596 glycine loop; other site 1110693002597 formate transporter; Provisional; Region: PRK10805 1110693002598 uncharacterized domain; Region: TIGR00702 1110693002599 YcaO-like family; Region: YcaO; pfam02624 1110693002600 Predicted membrane protein [Function unknown]; Region: COG2323 1110693002601 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1110693002602 homodimer interface [polypeptide binding]; other site 1110693002603 substrate-cofactor binding pocket; other site 1110693002604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693002605 catalytic residue [active] 1110693002606 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1110693002607 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 1110693002608 hinge; other site 1110693002609 active site 1110693002610 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1110693002611 cytidylate kinase; Provisional; Region: cmk; PRK00023 1110693002612 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1110693002613 CMP-binding site; other site 1110693002614 The sites determining sugar specificity; other site 1110693002615 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1110693002616 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1110693002617 RNA binding site [nucleotide binding]; other site 1110693002618 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1110693002619 RNA binding site [nucleotide binding]; other site 1110693002620 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1110693002621 RNA binding site [nucleotide binding]; other site 1110693002622 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1110693002623 RNA binding site [nucleotide binding]; other site 1110693002624 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1110693002625 RNA binding site [nucleotide binding]; other site 1110693002626 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1110693002627 IHF dimer interface [polypeptide binding]; other site 1110693002628 IHF - DNA interface [nucleotide binding]; other site 1110693002629 ComEC family competence protein; Provisional; Region: PRK11539 1110693002630 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1110693002631 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 1110693002632 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1110693002633 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1110693002634 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1110693002635 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1110693002636 Walker A/P-loop; other site 1110693002637 ATP binding site [chemical binding]; other site 1110693002638 Q-loop/lid; other site 1110693002639 ABC transporter signature motif; other site 1110693002640 Walker B; other site 1110693002641 D-loop; other site 1110693002642 H-loop/switch region; other site 1110693002643 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1110693002644 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1110693002645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1110693002646 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1110693002647 hypothetical protein; Provisional; Region: PRK11827 1110693002648 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1110693002649 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1110693002650 Ligand binding site; other site 1110693002651 oligomer interface; other site 1110693002652 hypothetical protein; Provisional; Region: PRK10593 1110693002653 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1110693002654 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1110693002655 putative active site [active] 1110693002656 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1110693002657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693002658 S-adenosylmethionine binding site [chemical binding]; other site 1110693002659 condesin subunit F; Provisional; Region: PRK05260 1110693002660 condesin subunit E; Provisional; Region: PRK05256 1110693002661 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1110693002662 MukB N-terminal; Region: MukB; pfam04310 1110693002663 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1110693002664 murein L,D-transpeptidase; Provisional; Region: PRK10594 1110693002665 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1110693002666 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1110693002667 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1110693002668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1110693002669 Peptidase M15; Region: Peptidase_M15_3; cl01194 1110693002670 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1110693002671 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1110693002672 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1110693002673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693002674 homodimer interface [polypeptide binding]; other site 1110693002675 catalytic residue [active] 1110693002676 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1110693002677 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1110693002678 trimer interface [polypeptide binding]; other site 1110693002679 eyelet of channel; other site 1110693002680 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1110693002681 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1110693002682 putative dimer interface [polypeptide binding]; other site 1110693002683 putative anticodon binding site; other site 1110693002684 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1110693002685 homodimer interface [polypeptide binding]; other site 1110693002686 motif 1; other site 1110693002687 motif 2; other site 1110693002688 active site 1110693002689 motif 3; other site 1110693002690 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1110693002691 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1110693002692 active site 1110693002693 aminopeptidase N; Provisional; Region: pepN; PRK14015 1110693002694 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1110693002695 active site 1110693002696 Zn binding site [ion binding]; other site 1110693002697 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1110693002698 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1110693002699 Walker A/P-loop; other site 1110693002700 ATP binding site [chemical binding]; other site 1110693002701 Q-loop/lid; other site 1110693002702 ABC transporter signature motif; other site 1110693002703 Walker B; other site 1110693002704 D-loop; other site 1110693002705 H-loop/switch region; other site 1110693002706 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1110693002707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693002708 dimer interface [polypeptide binding]; other site 1110693002709 conserved gate region; other site 1110693002710 putative PBP binding loops; other site 1110693002711 ABC-ATPase subunit interface; other site 1110693002712 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1110693002713 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1110693002714 active site 1110693002715 dimer interface [polypeptide binding]; other site 1110693002716 non-prolyl cis peptide bond; other site 1110693002717 insertion regions; other site 1110693002718 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693002719 substrate binding pocket [chemical binding]; other site 1110693002720 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1110693002721 membrane-bound complex binding site; other site 1110693002722 hinge residues; other site 1110693002723 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1110693002724 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1110693002725 Fimbrial protein; Region: Fimbrial; cl01416 1110693002726 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1110693002727 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1110693002728 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1110693002729 outer membrane usher protein; Provisional; Region: PRK15193 1110693002730 PapC N-terminal domain; Region: PapC_N; pfam13954 1110693002731 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1110693002732 PapC C-terminal domain; Region: PapC_C; pfam13953 1110693002733 Fimbrial protein; Region: Fimbrial; cl01416 1110693002734 Fimbrial protein; Region: Fimbrial; cl01416 1110693002735 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1110693002736 putativi pili assembly chaperone; Provisional; Region: PRK11385 1110693002737 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1110693002738 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1110693002739 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1110693002740 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1110693002741 quinone interaction residues [chemical binding]; other site 1110693002742 active site 1110693002743 catalytic residues [active] 1110693002744 FMN binding site [chemical binding]; other site 1110693002745 substrate binding site [chemical binding]; other site 1110693002746 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1110693002747 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1110693002748 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1110693002749 MOSC domain; Region: MOSC; pfam03473 1110693002750 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1110693002751 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1110693002752 catalytic loop [active] 1110693002753 iron binding site [ion binding]; other site 1110693002754 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1110693002755 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1110693002756 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1110693002757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693002758 S-adenosylmethionine binding site [chemical binding]; other site 1110693002759 ABC transporter ATPase component; Reviewed; Region: PRK11147 1110693002760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693002761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693002762 Walker A/P-loop; other site 1110693002763 Walker A/P-loop; other site 1110693002764 ATP binding site [chemical binding]; other site 1110693002765 ATP binding site [chemical binding]; other site 1110693002766 Q-loop/lid; other site 1110693002767 Q-loop/lid; other site 1110693002768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1110693002769 ABC transporter signature motif; other site 1110693002770 Walker B; other site 1110693002771 D-loop; other site 1110693002772 ABC transporter; Region: ABC_tran_2; pfam12848 1110693002773 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1110693002774 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1110693002775 Paraquat-inducible protein A; Region: PqiA; pfam04403 1110693002776 Paraquat-inducible protein A; Region: PqiA; pfam04403 1110693002777 paraquat-inducible protein B; Provisional; Region: PRK10807 1110693002778 mce related protein; Region: MCE; pfam02470 1110693002779 mce related protein; Region: MCE; pfam02470 1110693002780 mce related protein; Region: MCE; pfam02470 1110693002781 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 1110693002782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1110693002783 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1110693002784 ribosome modulation factor; Provisional; Region: PRK14563 1110693002785 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1110693002786 active site 1 [active] 1110693002787 dimer interface [polypeptide binding]; other site 1110693002788 active site 2 [active] 1110693002789 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1110693002790 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1110693002791 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1110693002792 outer membrane protein A; Reviewed; Region: PRK10808 1110693002793 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1110693002794 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1110693002795 ligand binding site [chemical binding]; other site 1110693002796 cell division inhibitor SulA; Region: sula; TIGR00623 1110693002797 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1110693002798 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1110693002799 TIGR01666 family membrane protein; Region: YCCS 1110693002800 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1110693002801 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1110693002802 Predicted membrane protein [Function unknown]; Region: COG3304 1110693002803 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1110693002804 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1110693002805 DNA helicase IV; Provisional; Region: helD; PRK11054 1110693002806 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1110693002807 Part of AAA domain; Region: AAA_19; pfam13245 1110693002808 Family description; Region: UvrD_C_2; pfam13538 1110693002809 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1110693002810 active site 1110693002811 dimer interfaces [polypeptide binding]; other site 1110693002812 catalytic residues [active] 1110693002813 hypothetical protein; Provisional; Region: PRK03641 1110693002814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1110693002815 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1110693002816 heat shock protein HspQ; Provisional; Region: PRK14129 1110693002817 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1110693002818 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1110693002819 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1110693002820 putative RNA binding site [nucleotide binding]; other site 1110693002821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693002822 S-adenosylmethionine binding site [chemical binding]; other site 1110693002823 Acylphosphatase; Region: Acylphosphatase; cl00551 1110693002824 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1110693002825 sulfur transfer protein TusE; Provisional; Region: PRK11508 1110693002826 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1110693002827 YccA-like proteins; Region: YccA_like; cd10433 1110693002828 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 1110693002829 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1110693002830 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1110693002831 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1110693002832 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1110693002833 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 1110693002834 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1110693002835 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1110693002836 putative substrate-binding site; other site 1110693002837 nickel binding site [ion binding]; other site 1110693002838 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1110693002839 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1110693002840 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 1110693002841 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1110693002842 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 1110693002843 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1110693002844 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1110693002845 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1110693002846 catalytic core [active] 1110693002847 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1110693002848 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1110693002849 DNA-binding site [nucleotide binding]; DNA binding site 1110693002850 RNA-binding motif; other site 1110693002851 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1110693002852 DNA-binding site [nucleotide binding]; DNA binding site 1110693002853 RNA-binding motif; other site 1110693002854 cold shock gene; Provisional; Region: PRK09891 1110693002855 GnsA/GnsB family; Region: GnsAB; pfam08178 1110693002856 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1110693002857 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1110693002858 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1110693002859 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1110693002860 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1110693002861 HAMP domain; Region: HAMP; pfam00672 1110693002862 dimerization interface [polypeptide binding]; other site 1110693002863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693002864 dimer interface [polypeptide binding]; other site 1110693002865 phosphorylation site [posttranslational modification] 1110693002866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693002867 ATP binding site [chemical binding]; other site 1110693002868 Mg2+ binding site [ion binding]; other site 1110693002869 G-X-G motif; other site 1110693002870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693002871 active site 1110693002872 phosphorylation site [posttranslational modification] 1110693002873 intermolecular recognition site; other site 1110693002874 dimerization interface [polypeptide binding]; other site 1110693002875 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1110693002876 putative binding surface; other site 1110693002877 active site 1110693002878 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 1110693002879 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 1110693002880 putative ligand binding site [chemical binding]; other site 1110693002881 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1110693002882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693002883 active site 1110693002884 phosphorylation site [posttranslational modification] 1110693002885 intermolecular recognition site; other site 1110693002886 dimerization interface [polypeptide binding]; other site 1110693002887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693002888 DNA binding site [nucleotide binding] 1110693002889 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 1110693002890 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1110693002891 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1110693002892 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1110693002893 molybdopterin cofactor binding site [chemical binding]; other site 1110693002894 substrate binding site [chemical binding]; other site 1110693002895 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1110693002896 molybdopterin cofactor binding site; other site 1110693002897 chaperone protein TorD; Validated; Region: torD; PRK04976 1110693002898 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1110693002899 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1110693002900 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1110693002901 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1110693002902 HSP70 interaction site [polypeptide binding]; other site 1110693002903 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1110693002904 substrate binding site [polypeptide binding]; other site 1110693002905 dimer interface [polypeptide binding]; other site 1110693002906 hypothetical protein; Provisional; Region: PRK09784 1110693002907 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1110693002908 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1110693002909 catalytic core [active] 1110693002910 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1110693002911 hypothetical protein; Provisional; Region: PRK10174 1110693002912 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1110693002913 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1110693002914 General stress protein [General function prediction only]; Region: GsiB; COG3729 1110693002915 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1110693002916 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 1110693002917 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1110693002918 putative FMN binding site [chemical binding]; other site 1110693002919 pyrimidine utilization protein D; Region: RutD; TIGR03611 1110693002920 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1110693002921 homotrimer interaction site [polypeptide binding]; other site 1110693002922 putative active site [active] 1110693002923 Isochorismatase family; Region: Isochorismatase; pfam00857 1110693002924 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1110693002925 catalytic triad [active] 1110693002926 conserved cis-peptide bond; other site 1110693002927 pyrimidine utilization protein A; Region: RutA; TIGR03612 1110693002928 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1110693002929 active site 1110693002930 dimer interface [polypeptide binding]; other site 1110693002931 non-prolyl cis peptide bond; other site 1110693002932 insertion regions; other site 1110693002933 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1110693002934 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1110693002935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1110693002936 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1110693002937 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1110693002938 Predicted transcriptional regulator [Transcription]; Region: COG3905 1110693002939 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1110693002940 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1110693002941 Glutamate binding site [chemical binding]; other site 1110693002942 NAD binding site [chemical binding]; other site 1110693002943 catalytic residues [active] 1110693002944 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1110693002945 Na binding site [ion binding]; other site 1110693002946 predicted membrane protein (pseudogene) 1110693002947 predicted protein, N-ter fragment (pseudogene) 1110693002948 predicted protein, C-ter fragment (pseudogene) 1110693002949 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1110693002950 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1110693002951 Imelysin; Region: Peptidase_M75; pfam09375 1110693002952 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1110693002953 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1110693002954 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1110693002955 hypothetical protein; Provisional; Region: PRK10536 1110693002956 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1110693002957 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1110693002958 putative ligand binding site [chemical binding]; other site 1110693002959 NAD binding site [chemical binding]; other site 1110693002960 dimerization interface [polypeptide binding]; other site 1110693002961 catalytic site [active] 1110693002962 putative hydrolase; Validated; Region: PRK09248 1110693002963 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1110693002964 active site 1110693002965 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1110693002966 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1110693002967 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1110693002968 curli assembly protein CsgF; Provisional; Region: PRK10050 1110693002969 curli assembly protein CsgE; Provisional; Region: PRK10386 1110693002970 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1110693002971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693002972 DNA binding residues [nucleotide binding] 1110693002973 dimerization interface [polypeptide binding]; other site 1110693002974 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1110693002975 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1110693002976 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1110693002977 major curlin subunit; Provisional; Region: csgA; PRK10051 1110693002978 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1110693002979 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1110693002980 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 1110693002981 Fimbrial protein; Region: Fimbrial; cl01416 1110693002982 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1110693002983 putative ADP-ribose binding site [chemical binding]; other site 1110693002984 putative active site [active] 1110693002985 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1110693002986 PLD-like domain; Region: PLDc_2; pfam13091 1110693002987 putative active site [active] 1110693002988 catalytic site [active] 1110693002989 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1110693002990 PLD-like domain; Region: PLDc_2; pfam13091 1110693002991 putative active site [active] 1110693002992 catalytic site [active] 1110693002993 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1110693002994 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1110693002995 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1110693002996 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1110693002997 lipoprotein; Provisional; Region: PRK10175 1110693002998 secY/secA suppressor protein; Provisional; Region: PRK11467 1110693002999 drug efflux system protein MdtG; Provisional; Region: PRK09874 1110693003000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693003001 putative substrate translocation pore; other site 1110693003002 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1110693003003 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1110693003004 putative acyl-acceptor binding pocket; other site 1110693003005 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1110693003006 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1110693003007 active site residue [active] 1110693003008 hypothetical protein; Provisional; Region: PRK03757 1110693003009 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1110693003010 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 1110693003011 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1110693003012 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1110693003013 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1110693003014 DNA damage-inducible protein I; Provisional; Region: PRK10597 1110693003015 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1110693003016 active site 1110693003017 substrate binding pocket [chemical binding]; other site 1110693003018 dimer interface [polypeptide binding]; other site 1110693003019 lipoprotein; Provisional; Region: PRK10598 1110693003020 glutaredoxin 2; Provisional; Region: PRK10387 1110693003021 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1110693003022 C-terminal domain interface [polypeptide binding]; other site 1110693003023 GSH binding site (G-site) [chemical binding]; other site 1110693003024 catalytic residues [active] 1110693003025 putative dimer interface [polypeptide binding]; other site 1110693003026 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1110693003027 N-terminal domain interface [polypeptide binding]; other site 1110693003028 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1110693003029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693003030 putative substrate translocation pore; other site 1110693003031 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1110693003032 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1110693003033 hypothetical protein; Provisional; Region: PRK11239 1110693003034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1110693003035 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1110693003036 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1110693003037 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1110693003038 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1110693003039 MviN-like protein; Region: MVIN; pfam03023 1110693003040 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1110693003041 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1110693003042 homodimer interface [polypeptide binding]; other site 1110693003043 oligonucleotide binding site [chemical binding]; other site 1110693003044 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1110693003045 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 1110693003046 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1110693003047 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1110693003048 RNA binding surface [nucleotide binding]; other site 1110693003049 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1110693003050 active site 1110693003051 Maf-like protein; Region: Maf; pfam02545 1110693003052 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1110693003053 active site 1110693003054 dimer interface [polypeptide binding]; other site 1110693003055 hypothetical protein; Provisional; Region: PRK11193 1110693003056 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1110693003057 putative phosphate acyltransferase; Provisional; Region: PRK05331 1110693003058 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1110693003059 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1110693003060 dimer interface [polypeptide binding]; other site 1110693003061 active site 1110693003062 CoA binding pocket [chemical binding]; other site 1110693003063 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1110693003064 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1110693003065 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1110693003066 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1110693003067 NAD(P) binding site [chemical binding]; other site 1110693003068 homotetramer interface [polypeptide binding]; other site 1110693003069 homodimer interface [polypeptide binding]; other site 1110693003070 active site 1110693003071 acyl carrier protein; Provisional; Region: acpP; PRK00982 1110693003072 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1110693003073 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1110693003074 dimer interface [polypeptide binding]; other site 1110693003075 active site 1110693003076 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1110693003077 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1110693003078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693003079 catalytic residue [active] 1110693003080 conserved hypothetical protein, YceG family; Region: TIGR00247 1110693003081 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1110693003082 dimerization interface [polypeptide binding]; other site 1110693003083 thymidylate kinase; Validated; Region: tmk; PRK00698 1110693003084 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1110693003085 TMP-binding site; other site 1110693003086 ATP-binding site [chemical binding]; other site 1110693003087 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1110693003088 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1110693003089 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1110693003090 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1110693003091 active site 1110693003092 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1110693003093 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1110693003094 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1110693003095 active site turn [active] 1110693003096 phosphorylation site [posttranslational modification] 1110693003097 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1110693003098 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1110693003099 N-terminal plug; other site 1110693003100 ligand-binding site [chemical binding]; other site 1110693003101 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1110693003102 nucleotide binding site/active site [active] 1110693003103 HIT family signature motif; other site 1110693003104 catalytic residue [active] 1110693003105 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1110693003106 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1110693003107 putative dimer interface [polypeptide binding]; other site 1110693003108 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1110693003109 thiamine kinase; Region: ycfN_thiK; TIGR02721 1110693003110 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1110693003111 active site 1110693003112 substrate binding site [chemical binding]; other site 1110693003113 ATP binding site [chemical binding]; other site 1110693003114 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1110693003115 beta-hexosaminidase; Provisional; Region: PRK05337 1110693003116 hypothetical protein; Provisional; Region: PRK04940 1110693003117 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1110693003118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693003119 hypothetical protein; Provisional; Region: PRK11280 1110693003120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1110693003121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1110693003122 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1110693003123 L,D-transpeptidase; Provisional; Region: PRK10260 1110693003124 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1110693003125 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1110693003126 transcription-repair coupling factor; Provisional; Region: PRK10689 1110693003127 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1110693003128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1110693003129 ATP binding site [chemical binding]; other site 1110693003130 putative Mg++ binding site [ion binding]; other site 1110693003131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1110693003132 nucleotide binding region [chemical binding]; other site 1110693003133 ATP-binding site [chemical binding]; other site 1110693003134 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1110693003135 Predicted membrane protein [Function unknown]; Region: COG4763 1110693003136 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1110693003137 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1110693003138 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1110693003139 FtsX-like permease family; Region: FtsX; pfam02687 1110693003140 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1110693003141 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1110693003142 Walker A/P-loop; other site 1110693003143 ATP binding site [chemical binding]; other site 1110693003144 Q-loop/lid; other site 1110693003145 ABC transporter signature motif; other site 1110693003146 Walker B; other site 1110693003147 D-loop; other site 1110693003148 H-loop/switch region; other site 1110693003149 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1110693003150 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1110693003151 FtsX-like permease family; Region: FtsX; pfam02687 1110693003152 fructokinase; Reviewed; Region: PRK09557 1110693003153 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1110693003154 nucleotide binding site [chemical binding]; other site 1110693003155 NAD-dependent deacetylase; Provisional; Region: PRK00481 1110693003156 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1110693003157 NAD+ binding site [chemical binding]; other site 1110693003158 substrate binding site [chemical binding]; other site 1110693003159 Zn binding site [ion binding]; other site 1110693003160 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1110693003161 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1110693003162 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1110693003163 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1110693003164 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1110693003165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693003166 dimer interface [polypeptide binding]; other site 1110693003167 conserved gate region; other site 1110693003168 putative PBP binding loops; other site 1110693003169 ABC-ATPase subunit interface; other site 1110693003170 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1110693003171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693003172 dimer interface [polypeptide binding]; other site 1110693003173 conserved gate region; other site 1110693003174 putative PBP binding loops; other site 1110693003175 ABC-ATPase subunit interface; other site 1110693003176 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1110693003177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693003178 Walker A/P-loop; other site 1110693003179 ATP binding site [chemical binding]; other site 1110693003180 Q-loop/lid; other site 1110693003181 ABC transporter signature motif; other site 1110693003182 Walker B; other site 1110693003183 D-loop; other site 1110693003184 H-loop/switch region; other site 1110693003185 TOBE domain; Region: TOBE_2; pfam08402 1110693003186 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1110693003187 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1110693003188 metal binding site [ion binding]; metal-binding site 1110693003189 dimer interface [polypeptide binding]; other site 1110693003190 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1110693003191 Cupin-like domain; Region: Cupin_8; pfam13621 1110693003192 sensor protein PhoQ; Provisional; Region: PRK10815 1110693003193 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1110693003194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1110693003195 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1110693003196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693003197 ATP binding site [chemical binding]; other site 1110693003198 Mg2+ binding site [ion binding]; other site 1110693003199 G-X-G motif; other site 1110693003200 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1110693003201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693003202 active site 1110693003203 phosphorylation site [posttranslational modification] 1110693003204 intermolecular recognition site; other site 1110693003205 dimerization interface [polypeptide binding]; other site 1110693003206 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693003207 DNA binding site [nucleotide binding] 1110693003208 adenylosuccinate lyase; Provisional; Region: PRK09285 1110693003209 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1110693003210 tetramer interface [polypeptide binding]; other site 1110693003211 active site 1110693003212 putative lysogenization regulator; Reviewed; Region: PRK00218 1110693003213 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1110693003214 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1110693003215 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1110693003216 nudix motif; other site 1110693003217 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1110693003218 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1110693003219 probable active site [active] 1110693003220 isocitrate dehydrogenase; Validated; Region: PRK07362 1110693003221 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1110693003222 conserved protein (pseudogene) 1110693003223 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1110693003224 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1110693003225 cell division inhibitor MinD; Provisional; Region: PRK10818 1110693003226 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1110693003227 Switch I; other site 1110693003228 Switch II; other site 1110693003229 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1110693003230 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1110693003231 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1110693003232 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1110693003233 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1110693003234 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1110693003235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1110693003236 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1110693003237 hypothetical protein; Provisional; Region: PRK10691 1110693003238 hypothetical protein; Provisional; Region: PRK05170 1110693003239 hemolysin E; Provisional; Region: hlyE; PRK11376 1110693003240 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1110693003241 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1110693003242 Catalytic site [active] 1110693003243 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1110693003244 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1110693003245 active site 1110693003246 DNA binding site [nucleotide binding] 1110693003247 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1110693003248 disulfide bond formation protein B; Provisional; Region: PRK01749 1110693003249 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1110693003250 transmembrane helices; other site 1110693003251 fatty acid metabolism regulator; Provisional; Region: PRK04984 1110693003252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693003253 DNA-binding site [nucleotide binding]; DNA binding site 1110693003254 FadR C-terminal domain; Region: FadR_C; pfam07840 1110693003255 SpoVR family protein; Provisional; Region: PRK11767 1110693003256 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1110693003257 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1110693003258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693003259 alanine racemase; Reviewed; Region: dadX; PRK03646 1110693003260 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1110693003261 active site 1110693003262 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1110693003263 substrate binding site [chemical binding]; other site 1110693003264 catalytic residues [active] 1110693003265 dimer interface [polypeptide binding]; other site 1110693003266 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1110693003267 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1110693003268 TrkA-C domain; Region: TrkA_C; pfam02080 1110693003269 Transporter associated domain; Region: CorC_HlyC; smart01091 1110693003270 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1110693003271 dimer interface [polypeptide binding]; other site 1110693003272 catalytic triad [active] 1110693003273 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1110693003274 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1110693003275 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1110693003276 catalytic residue [active] 1110693003277 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1110693003278 Flagellar regulator YcgR; Region: YcgR; pfam07317 1110693003279 PilZ domain; Region: PilZ; pfam07238 1110693003280 hypothetical protein; Provisional; Region: PRK10457 1110693003281 trehalase; Provisional; Region: treA; PRK13271 1110693003282 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1110693003283 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1110693003284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 1110693003285 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1110693003286 dimerization domain swap beta strand [polypeptide binding]; other site 1110693003287 regulatory protein interface [polypeptide binding]; other site 1110693003288 active site 1110693003289 regulatory phosphorylation site [posttranslational modification]; other site 1110693003290 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1110693003291 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1110693003292 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 1110693003293 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1110693003294 Dak1 domain; Region: Dak1; pfam02733 1110693003295 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 1110693003296 PAS domain; Region: PAS; smart00091 1110693003297 putative active site [active] 1110693003298 heme pocket [chemical binding]; other site 1110693003299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693003300 Walker A motif; other site 1110693003301 ATP binding site [chemical binding]; other site 1110693003302 Walker B motif; other site 1110693003303 arginine finger; other site 1110693003304 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1110693003305 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1110693003306 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1110693003307 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1110693003308 GTP-binding protein YchF; Reviewed; Region: PRK09601 1110693003309 YchF GTPase; Region: YchF; cd01900 1110693003310 G1 box; other site 1110693003311 GTP/Mg2+ binding site [chemical binding]; other site 1110693003312 Switch I region; other site 1110693003313 G2 box; other site 1110693003314 Switch II region; other site 1110693003315 G3 box; other site 1110693003316 G4 box; other site 1110693003317 G5 box; other site 1110693003318 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1110693003319 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1110693003320 putative active site [active] 1110693003321 catalytic residue [active] 1110693003322 hypothetical protein; Provisional; Region: PRK10692 1110693003323 putative transporter; Provisional; Region: PRK11660 1110693003324 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1110693003325 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1110693003326 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1110693003327 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1110693003328 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1110693003329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1110693003330 active site 1110693003331 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1110693003332 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1110693003333 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1110693003334 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 1110693003335 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1110693003336 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1110693003337 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1110693003338 tRNA; other site 1110693003339 putative tRNA binding site [nucleotide binding]; other site 1110693003340 putative NADP binding site [chemical binding]; other site 1110693003341 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1110693003342 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1110693003343 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1110693003344 RF-1 domain; Region: RF-1; pfam00472 1110693003345 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1110693003346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693003347 hypothetical protein; Provisional; Region: PRK10278 1110693003348 hypothetical protein; Provisional; Region: PRK10941 1110693003349 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1110693003350 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1110693003351 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1110693003352 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1110693003353 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1110693003354 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1110693003355 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1110693003356 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1110693003357 cation transport regulator; Reviewed; Region: chaB; PRK09582 1110693003358 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1110693003359 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1110693003360 putative active site pocket [active] 1110693003361 dimerization interface [polypeptide binding]; other site 1110693003362 putative catalytic residue [active] 1110693003363 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1110693003364 putative invasin; Provisional; Region: PRK10177 1110693003365 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1110693003366 transcriptional regulator NarL; Provisional; Region: PRK10651 1110693003367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693003368 active site 1110693003369 phosphorylation site [posttranslational modification] 1110693003370 intermolecular recognition site; other site 1110693003371 dimerization interface [polypeptide binding]; other site 1110693003372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693003373 DNA binding residues [nucleotide binding] 1110693003374 dimerization interface [polypeptide binding]; other site 1110693003375 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1110693003376 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1110693003377 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1110693003378 dimerization interface [polypeptide binding]; other site 1110693003379 Histidine kinase; Region: HisKA_3; pfam07730 1110693003380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693003381 ATP binding site [chemical binding]; other site 1110693003382 Mg2+ binding site [ion binding]; other site 1110693003383 G-X-G motif; other site 1110693003384 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1110693003385 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1110693003386 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1110693003387 [4Fe-4S] binding site [ion binding]; other site 1110693003388 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1110693003389 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1110693003390 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1110693003391 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1110693003392 molybdopterin cofactor binding site; other site 1110693003393 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1110693003394 4Fe-4S binding domain; Region: Fer4; cl02805 1110693003395 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1110693003396 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1110693003397 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1110693003398 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1110693003399 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1110693003400 putative active site [active] 1110693003401 putative substrate binding site [chemical binding]; other site 1110693003402 putative cosubstrate binding site; other site 1110693003403 catalytic site [active] 1110693003404 SEC-C motif; Region: SEC-C; pfam02810 1110693003405 hypothetical protein; Provisional; Region: PRK04233 1110693003406 hypothetical protein; Provisional; Region: PRK10279 1110693003407 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1110693003408 active site 1110693003409 nucleophile elbow; other site 1110693003410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693003411 active site 1110693003412 response regulator of RpoS; Provisional; Region: PRK10693 1110693003413 phosphorylation site [posttranslational modification] 1110693003414 intermolecular recognition site; other site 1110693003415 dimerization interface [polypeptide binding]; other site 1110693003416 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1110693003417 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1110693003418 active site 1110693003419 tetramer interface; other site 1110693003420 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1110693003421 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1110693003422 thymidine kinase; Provisional; Region: PRK04296 1110693003423 predicted protein, C-ter fragment (pseudogene) 1110693003424 predicted protein (pseudogene) 1110693003425 predicted protein, N-ter fragment (pseudogene) 1110693003426 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1110693003427 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1110693003428 putative catalytic cysteine [active] 1110693003429 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1110693003430 putative active site [active] 1110693003431 metal binding site [ion binding]; metal-binding site 1110693003432 hypothetical protein; Provisional; Region: PRK11111 1110693003433 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1110693003434 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1110693003435 peptide binding site [polypeptide binding]; other site 1110693003436 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1110693003437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693003438 dimer interface [polypeptide binding]; other site 1110693003439 conserved gate region; other site 1110693003440 putative PBP binding loops; other site 1110693003441 ABC-ATPase subunit interface; other site 1110693003442 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1110693003443 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1110693003444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693003445 dimer interface [polypeptide binding]; other site 1110693003446 conserved gate region; other site 1110693003447 putative PBP binding loops; other site 1110693003448 ABC-ATPase subunit interface; other site 1110693003449 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1110693003450 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693003451 Walker A/P-loop; other site 1110693003452 ATP binding site [chemical binding]; other site 1110693003453 Q-loop/lid; other site 1110693003454 ABC transporter signature motif; other site 1110693003455 Walker B; other site 1110693003456 D-loop; other site 1110693003457 H-loop/switch region; other site 1110693003458 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1110693003459 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1110693003460 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693003461 Walker A/P-loop; other site 1110693003462 ATP binding site [chemical binding]; other site 1110693003463 Q-loop/lid; other site 1110693003464 ABC transporter signature motif; other site 1110693003465 Walker B; other site 1110693003466 D-loop; other site 1110693003467 H-loop/switch region; other site 1110693003468 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1110693003469 dsDNA-mimic protein; Reviewed; Region: PRK05094 1110693003470 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1110693003471 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1110693003472 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1110693003473 putative active site [active] 1110693003474 catalytic site [active] 1110693003475 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1110693003476 putative active site [active] 1110693003477 catalytic site [active] 1110693003478 voltage-gated potassium channel; Provisional; Region: PRK10537 1110693003479 Ion channel; Region: Ion_trans_2; pfam07885 1110693003480 TrkA-N domain; Region: TrkA_N; pfam02254 1110693003481 YciI-like protein; Reviewed; Region: PRK11370 1110693003482 transport protein TonB; Provisional; Region: PRK10819 1110693003483 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1110693003484 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1110693003485 intracellular septation protein A; Reviewed; Region: PRK00259 1110693003486 hypothetical protein; Provisional; Region: PRK02868 1110693003487 outer membrane protein W; Provisional; Region: PRK10959 1110693003488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 1110693003489 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1110693003490 dimerization interface [polypeptide binding]; other site 1110693003491 metal binding site [ion binding]; metal-binding site 1110693003492 General stress protein [General function prediction only]; Region: GsiB; COG3729 1110693003493 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1110693003494 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1110693003495 substrate binding site [chemical binding]; other site 1110693003496 active site 1110693003497 catalytic residues [active] 1110693003498 heterodimer interface [polypeptide binding]; other site 1110693003499 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1110693003500 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1110693003501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693003502 catalytic residue [active] 1110693003503 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1110693003504 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1110693003505 active site 1110693003506 ribulose/triose binding site [chemical binding]; other site 1110693003507 phosphate binding site [ion binding]; other site 1110693003508 substrate (anthranilate) binding pocket [chemical binding]; other site 1110693003509 product (indole) binding pocket [chemical binding]; other site 1110693003510 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1110693003511 active site 1110693003512 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1110693003513 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1110693003514 glutamine binding [chemical binding]; other site 1110693003515 catalytic triad [active] 1110693003516 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1110693003517 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1110693003518 anthranilate synthase component I; Provisional; Region: PRK13564 1110693003519 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1110693003520 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1110693003521 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1110693003522 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1110693003523 active site 1110693003524 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1110693003525 hypothetical protein; Provisional; Region: PRK11630 1110693003526 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1110693003527 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1110693003528 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1110693003529 RNA binding surface [nucleotide binding]; other site 1110693003530 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1110693003531 probable active site [active] 1110693003532 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1110693003533 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1110693003534 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1110693003535 homodimer interface [polypeptide binding]; other site 1110693003536 Walker A motif; other site 1110693003537 ATP binding site [chemical binding]; other site 1110693003538 hydroxycobalamin binding site [chemical binding]; other site 1110693003539 Walker B motif; other site 1110693003540 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1110693003541 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1110693003542 NADP binding site [chemical binding]; other site 1110693003543 homodimer interface [polypeptide binding]; other site 1110693003544 active site 1110693003545 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1110693003546 putative inner membrane peptidase; Provisional; Region: PRK11778 1110693003547 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1110693003548 tandem repeat interface [polypeptide binding]; other site 1110693003549 oligomer interface [polypeptide binding]; other site 1110693003550 active site residues [active] 1110693003551 hypothetical protein; Provisional; Region: PRK11037 1110693003552 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1110693003553 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1110693003554 active site 1110693003555 interdomain interaction site; other site 1110693003556 putative metal-binding site [ion binding]; other site 1110693003557 nucleotide binding site [chemical binding]; other site 1110693003558 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1110693003559 domain I; other site 1110693003560 DNA binding groove [nucleotide binding] 1110693003561 phosphate binding site [ion binding]; other site 1110693003562 domain II; other site 1110693003563 domain III; other site 1110693003564 nucleotide binding site [chemical binding]; other site 1110693003565 catalytic site [active] 1110693003566 domain IV; other site 1110693003567 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1110693003568 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1110693003569 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1110693003570 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1110693003571 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1110693003572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693003573 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1110693003574 substrate binding site [chemical binding]; other site 1110693003575 putative dimerization interface [polypeptide binding]; other site 1110693003576 predicted protein, N-ter fragment (pseudogene) 1110693003577 predicted protein (pseudogene) 1110693003578 predicted protein, C-ter fragment (pseudogene) 1110693003579 aconitate hydratase; Validated; Region: PRK09277 1110693003580 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1110693003581 substrate binding site [chemical binding]; other site 1110693003582 ligand binding site [chemical binding]; other site 1110693003583 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1110693003584 substrate binding site [chemical binding]; other site 1110693003585 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1110693003586 dimerization interface [polypeptide binding]; other site 1110693003587 active site 1110693003588 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1110693003589 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1110693003590 active site 1110693003591 Predicted membrane protein [Function unknown]; Region: COG3771 1110693003592 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1110693003593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1110693003594 TPR motif; other site 1110693003595 binding surface 1110693003596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1110693003597 binding surface 1110693003598 TPR motif; other site 1110693003599 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1110693003600 active site 1110693003601 dimer interface [polypeptide binding]; other site 1110693003602 translation initiation factor Sui1; Validated; Region: PRK06824 1110693003603 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1110693003604 putative rRNA binding site [nucleotide binding]; other site 1110693003605 lipoprotein; Provisional; Region: PRK10540 1110693003606 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1110693003607 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1110693003608 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1110693003609 RNase II stability modulator; Provisional; Region: PRK10060 1110693003610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1110693003611 putative active site [active] 1110693003612 heme pocket [chemical binding]; other site 1110693003613 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693003614 metal binding site [ion binding]; metal-binding site 1110693003615 active site 1110693003616 I-site; other site 1110693003617 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1110693003618 exoribonuclease II; Provisional; Region: PRK05054 1110693003619 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1110693003620 RNB domain; Region: RNB; pfam00773 1110693003621 S1 RNA binding domain; Region: S1; pfam00575 1110693003622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 1110693003623 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1110693003624 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1110693003625 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1110693003626 NAD binding site [chemical binding]; other site 1110693003627 homotetramer interface [polypeptide binding]; other site 1110693003628 homodimer interface [polypeptide binding]; other site 1110693003629 substrate binding site [chemical binding]; other site 1110693003630 active site 1110693003631 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1110693003632 putative active site [active] 1110693003633 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1110693003634 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693003635 Walker A/P-loop; other site 1110693003636 ATP binding site [chemical binding]; other site 1110693003637 Q-loop/lid; other site 1110693003638 ABC transporter signature motif; other site 1110693003639 Walker B; other site 1110693003640 D-loop; other site 1110693003641 H-loop/switch region; other site 1110693003642 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1110693003643 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693003644 Walker A/P-loop; other site 1110693003645 ATP binding site [chemical binding]; other site 1110693003646 Q-loop/lid; other site 1110693003647 ABC transporter signature motif; other site 1110693003648 Walker B; other site 1110693003649 D-loop; other site 1110693003650 H-loop/switch region; other site 1110693003651 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1110693003652 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1110693003653 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1110693003654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693003655 dimer interface [polypeptide binding]; other site 1110693003656 conserved gate region; other site 1110693003657 putative PBP binding loops; other site 1110693003658 ABC-ATPase subunit interface; other site 1110693003659 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1110693003660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693003661 dimer interface [polypeptide binding]; other site 1110693003662 conserved gate region; other site 1110693003663 putative PBP binding loops; other site 1110693003664 ABC-ATPase subunit interface; other site 1110693003665 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1110693003666 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1110693003667 peptide binding site [polypeptide binding]; other site 1110693003668 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1110693003669 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1110693003670 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1110693003671 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1110693003672 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 1110693003673 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1110693003674 catalytic triad [active] 1110693003675 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1110693003676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1110693003677 non-specific DNA binding site [nucleotide binding]; other site 1110693003678 salt bridge; other site 1110693003679 sequence-specific DNA binding site [nucleotide binding]; other site 1110693003680 Cupin domain; Region: Cupin_2; pfam07883 1110693003681 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1110693003682 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1110693003683 NAD(P) binding site [chemical binding]; other site 1110693003684 catalytic residues [active] 1110693003685 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1110693003686 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1110693003687 4-aminobutyrate transaminase; Provisional; Region: PRK09792 1110693003688 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1110693003689 inhibitor-cofactor binding pocket; inhibition site 1110693003690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693003691 catalytic residue [active] 1110693003692 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1110693003693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693003694 Walker A motif; other site 1110693003695 ATP binding site [chemical binding]; other site 1110693003696 Walker B motif; other site 1110693003697 arginine finger; other site 1110693003698 phage shock protein PspA; Provisional; Region: PRK10698 1110693003699 phage shock protein B; Provisional; Region: pspB; PRK09458 1110693003700 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1110693003701 phage shock protein C; Region: phageshock_pspC; TIGR02978 1110693003702 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1110693003703 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1110693003704 active site residue [active] 1110693003705 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1110693003706 sucrose phosphorylase; Provisional; Region: PRK13840 1110693003707 active site 1110693003708 homodimer interface [polypeptide binding]; other site 1110693003709 catalytic site [active] 1110693003710 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1110693003711 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1110693003712 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1110693003713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693003714 dimer interface [polypeptide binding]; other site 1110693003715 conserved gate region; other site 1110693003716 putative PBP binding loops; other site 1110693003717 ABC-ATPase subunit interface; other site 1110693003718 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1110693003719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693003720 dimer interface [polypeptide binding]; other site 1110693003721 conserved gate region; other site 1110693003722 putative PBP binding loops; other site 1110693003723 ABC-ATPase subunit interface; other site 1110693003724 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1110693003725 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1110693003726 putative NAD(P) binding site [chemical binding]; other site 1110693003727 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1110693003728 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1110693003729 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1110693003730 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1110693003731 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1110693003732 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1110693003733 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1110693003734 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1110693003735 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1110693003736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693003737 motif II; other site 1110693003738 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1110693003739 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1110693003740 Walker A/P-loop; other site 1110693003741 ATP binding site [chemical binding]; other site 1110693003742 Q-loop/lid; other site 1110693003743 ABC transporter signature motif; other site 1110693003744 Walker B; other site 1110693003745 D-loop; other site 1110693003746 H-loop/switch region; other site 1110693003747 TOBE domain; Region: TOBE_2; pfam08402 1110693003748 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1110693003749 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 1110693003750 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1110693003751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693003752 DNA binding site [nucleotide binding] 1110693003753 domain linker motif; other site 1110693003754 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1110693003755 putative dimerization interface [polypeptide binding]; other site 1110693003756 putative ligand binding site [chemical binding]; other site 1110693003757 Predicted ATPase [General function prediction only]; Region: COG3106 1110693003758 hypothetical protein; Provisional; Region: PRK05415 1110693003759 TIGR01620 family protein; Region: hyp_HI0043 1110693003760 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1110693003761 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1110693003762 putative aromatic amino acid binding site; other site 1110693003763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693003764 Walker A motif; other site 1110693003765 ATP binding site [chemical binding]; other site 1110693003766 Walker B motif; other site 1110693003767 arginine finger; other site 1110693003768 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1110693003769 dimer interface [polypeptide binding]; other site 1110693003770 catalytic triad [active] 1110693003771 peroxidatic and resolving cysteines [active] 1110693003772 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1110693003773 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1110693003774 ligand binding site [chemical binding]; other site 1110693003775 flexible hinge region; other site 1110693003776 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1110693003777 putative switch regulator; other site 1110693003778 non-specific DNA interactions [nucleotide binding]; other site 1110693003779 DNA binding site [nucleotide binding] 1110693003780 sequence specific DNA binding site [nucleotide binding]; other site 1110693003781 putative cAMP binding site [chemical binding]; other site 1110693003782 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1110693003783 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1110693003784 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1110693003785 DNA binding site [nucleotide binding] 1110693003786 active site 1110693003787 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1110693003788 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1110693003789 ATP binding site [chemical binding]; other site 1110693003790 putative Mg++ binding site [ion binding]; other site 1110693003791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1110693003792 nucleotide binding region [chemical binding]; other site 1110693003793 ATP-binding site [chemical binding]; other site 1110693003794 Helicase associated domain (HA2); Region: HA2; pfam04408 1110693003795 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1110693003796 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1110693003797 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1110693003798 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1110693003799 putative active site [active] 1110693003800 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1110693003801 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1110693003802 NAD binding site [chemical binding]; other site 1110693003803 catalytic residues [active] 1110693003804 substrate binding site [chemical binding]; other site 1110693003805 glyceraldehyde-3-phosphate dehydrogenase C, N-ter fragment (pseudogene) 1110693003806 glyceraldehyde-3-phosphate dehydrogenase C (pseudogene) 1110693003807 glyceraldehyde-3-phosphate dehydrogenase C, C-ter fragment (pseudogene) 1110693003808 cytochrome b561; Provisional; Region: PRK11513 1110693003809 hypothetical protein; Provisional; Region: PRK10040 1110693003810 small toxic polypeptide; Provisional; Region: PRK09738 1110693003811 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1110693003812 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1110693003813 dimer interface [polypeptide binding]; other site 1110693003814 ligand binding site [chemical binding]; other site 1110693003815 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1110693003816 dimerization interface [polypeptide binding]; other site 1110693003817 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1110693003818 dimer interface [polypeptide binding]; other site 1110693003819 putative CheW interface [polypeptide binding]; other site 1110693003820 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1110693003821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693003822 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1110693003823 dimerization interface [polypeptide binding]; other site 1110693003824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1110693003825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1110693003826 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1110693003827 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1110693003828 hypothetical protein; Provisional; Region: PRK11415 1110693003829 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1110693003830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1110693003831 Coenzyme A binding pocket [chemical binding]; other site 1110693003832 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1110693003833 putative trimer interface [polypeptide binding]; other site 1110693003834 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1110693003835 putative CoA binding site [chemical binding]; other site 1110693003836 putative trimer interface [polypeptide binding]; other site 1110693003837 putative CoA binding site [chemical binding]; other site 1110693003838 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1110693003839 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1110693003840 gating phenylalanine in ion channel; other site 1110693003841 tellurite resistance protein TehB; Provisional; Region: PRK11207 1110693003842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693003843 S-adenosylmethionine binding site [chemical binding]; other site 1110693003844 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1110693003845 predicted transposase, N-ter fragment (pseudogene) 1110693003846 predicted transposase (pseudogene) 1110693003847 predicted transposase, C-ter fragment (pseudogene) 1110693003848 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1110693003849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1110693003850 Probable transposase; Region: OrfB_IS605; pfam01385 1110693003851 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1110693003852 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1110693003853 benzoate transporter; Region: benE; TIGR00843 1110693003854 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1110693003855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1110693003856 non-specific DNA binding site [nucleotide binding]; other site 1110693003857 salt bridge; other site 1110693003858 sequence-specific DNA binding site [nucleotide binding]; other site 1110693003859 Cupin domain; Region: Cupin_2; pfam07883 1110693003860 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1110693003861 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1110693003862 Peptidase family U32; Region: Peptidase_U32; pfam01136 1110693003863 Collagenase; Region: DUF3656; pfam12392 1110693003864 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1110693003865 YcfA-like protein; Region: YcfA; pfam07927 1110693003866 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1110693003867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1110693003868 sequence-specific DNA binding site [nucleotide binding]; other site 1110693003869 salt bridge; other site 1110693003870 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1110693003871 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693003872 DNA-binding site [nucleotide binding]; DNA binding site 1110693003873 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1110693003874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693003875 homodimer interface [polypeptide binding]; other site 1110693003876 catalytic residue [active] 1110693003877 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1110693003878 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1110693003879 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1110693003880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693003881 Walker A/P-loop; other site 1110693003882 ATP binding site [chemical binding]; other site 1110693003883 Q-loop/lid; other site 1110693003884 ABC transporter signature motif; other site 1110693003885 Walker B; other site 1110693003886 D-loop; other site 1110693003887 H-loop/switch region; other site 1110693003888 TOBE domain; Region: TOBE_2; pfam08402 1110693003889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693003890 dimer interface [polypeptide binding]; other site 1110693003891 conserved gate region; other site 1110693003892 putative PBP binding loops; other site 1110693003893 ABC-ATPase subunit interface; other site 1110693003894 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1110693003895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693003896 ABC-ATPase subunit interface; other site 1110693003897 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1110693003898 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1110693003899 tetrameric interface [polypeptide binding]; other site 1110693003900 NAD binding site [chemical binding]; other site 1110693003901 catalytic residues [active] 1110693003902 substrate binding site [chemical binding]; other site 1110693003903 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1110693003904 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1110693003905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1110693003906 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1110693003907 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1110693003908 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1110693003909 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1110693003910 NAD(P) binding site [chemical binding]; other site 1110693003911 substrate binding site [chemical binding]; other site 1110693003912 dimer interface [polypeptide binding]; other site 1110693003913 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1110693003914 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693003915 DNA-binding site [nucleotide binding]; DNA binding site 1110693003916 FCD domain; Region: FCD; pfam07729 1110693003917 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1110693003918 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1110693003919 N-terminal plug; other site 1110693003920 ligand-binding site [chemical binding]; other site 1110693003921 PQQ-like domain; Region: PQQ_2; pfam13360 1110693003922 L-asparagine permease; Provisional; Region: PRK15049 1110693003923 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1110693003924 C-terminal domain interface [polypeptide binding]; other site 1110693003925 GSH binding site (G-site) [chemical binding]; other site 1110693003926 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1110693003927 dimer interface [polypeptide binding]; other site 1110693003928 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1110693003929 dimer interface [polypeptide binding]; other site 1110693003930 N-terminal domain interface [polypeptide binding]; other site 1110693003931 substrate binding pocket (H-site) [chemical binding]; other site 1110693003932 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1110693003933 hypothetical protein; Provisional; Region: PRK10281 1110693003934 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1110693003935 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1110693003936 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1110693003937 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1110693003938 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1110693003939 [4Fe-4S] binding site [ion binding]; other site 1110693003940 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1110693003941 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1110693003942 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1110693003943 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1110693003944 molybdopterin cofactor binding site; other site 1110693003945 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1110693003946 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1110693003947 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1110693003948 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1110693003949 aromatic amino acid exporter; Provisional; Region: PRK11689 1110693003950 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1110693003951 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1110693003952 [4Fe-4S] binding site [ion binding]; other site 1110693003953 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1110693003954 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1110693003955 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1110693003956 molybdopterin cofactor binding site; other site 1110693003957 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1110693003958 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1110693003959 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1110693003960 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1110693003961 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1110693003962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1110693003963 non-specific DNA binding site [nucleotide binding]; other site 1110693003964 salt bridge; other site 1110693003965 sequence-specific DNA binding site [nucleotide binding]; other site 1110693003966 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1110693003967 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1110693003968 NAD binding site [chemical binding]; other site 1110693003969 substrate binding site [chemical binding]; other site 1110693003970 catalytic Zn binding site [ion binding]; other site 1110693003971 tetramer interface [polypeptide binding]; other site 1110693003972 structural Zn binding site [ion binding]; other site 1110693003973 malate dehydrogenase; Provisional; Region: PRK13529 1110693003974 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1110693003975 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1110693003976 NAD(P) binding site [chemical binding]; other site 1110693003977 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1110693003978 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 1110693003979 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1110693003980 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1110693003981 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693003982 Walker A/P-loop; other site 1110693003983 ATP binding site [chemical binding]; other site 1110693003984 Q-loop/lid; other site 1110693003985 ABC transporter signature motif; other site 1110693003986 Walker B; other site 1110693003987 D-loop; other site 1110693003988 H-loop/switch region; other site 1110693003989 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1110693003990 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1110693003991 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693003992 Walker A/P-loop; other site 1110693003993 ATP binding site [chemical binding]; other site 1110693003994 Q-loop/lid; other site 1110693003995 ABC transporter signature motif; other site 1110693003996 Walker B; other site 1110693003997 D-loop; other site 1110693003998 H-loop/switch region; other site 1110693003999 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1110693004000 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 1110693004001 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1110693004002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693004003 dimer interface [polypeptide binding]; other site 1110693004004 conserved gate region; other site 1110693004005 putative PBP binding loops; other site 1110693004006 ABC-ATPase subunit interface; other site 1110693004007 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1110693004008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693004009 dimer interface [polypeptide binding]; other site 1110693004010 conserved gate region; other site 1110693004011 putative PBP binding loops; other site 1110693004012 ABC-ATPase subunit interface; other site 1110693004013 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1110693004014 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1110693004015 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 1110693004016 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 1110693004017 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1110693004018 putative active site [active] 1110693004019 heme pocket [chemical binding]; other site 1110693004020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1110693004021 putative active site [active] 1110693004022 heme pocket [chemical binding]; other site 1110693004023 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693004024 metal binding site [ion binding]; metal-binding site 1110693004025 active site 1110693004026 I-site; other site 1110693004027 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1110693004028 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1110693004029 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693004030 metal binding site [ion binding]; metal-binding site 1110693004031 active site 1110693004032 I-site; other site 1110693004033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1110693004034 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1110693004035 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1110693004036 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1110693004037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693004038 catalytic residue [active] 1110693004039 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1110693004040 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1110693004041 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1110693004042 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1110693004043 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1110693004044 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1110693004045 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1110693004046 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1110693004047 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1110693004048 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1110693004049 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1110693004050 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693004051 FeS/SAM binding site; other site 1110693004052 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1110693004053 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1110693004054 Sulfatase; Region: Sulfatase; pfam00884 1110693004055 transcriptional regulator YdeO; Provisional; Region: PRK09940 1110693004056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693004057 putative oxidoreductase; Provisional; Region: PRK09939 1110693004058 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1110693004059 putative molybdopterin cofactor binding site [chemical binding]; other site 1110693004060 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1110693004061 putative molybdopterin cofactor binding site; other site 1110693004062 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 1110693004063 mannosyl binding site [chemical binding]; other site 1110693004064 Fimbrial protein; Region: Fimbrial; pfam00419 1110693004065 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1110693004066 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1110693004067 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1110693004068 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1110693004069 PapC C-terminal domain; Region: PapC_C; pfam13953 1110693004070 Helix-turn-helix domain; Region: HTH_18; pfam12833 1110693004071 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1110693004072 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1110693004073 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1110693004074 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1110693004075 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1110693004076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1110693004077 non-specific DNA binding site [nucleotide binding]; other site 1110693004078 salt bridge; other site 1110693004079 sequence-specific DNA binding site [nucleotide binding]; other site 1110693004080 conserved protein, predicted pseudogene 1110693004081 putative lipoprotein; Provisional; Region: PRK09707 1110693004082 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1110693004083 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1110693004084 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1110693004085 putative N- and C-terminal domain interface [polypeptide binding]; other site 1110693004086 putative active site [active] 1110693004087 putative MgATP binding site [chemical binding]; other site 1110693004088 catalytic site [active] 1110693004089 metal binding site [ion binding]; metal-binding site 1110693004090 putative carbohydrate binding site [chemical binding]; other site 1110693004091 transcriptional regulator LsrR; Provisional; Region: PRK15418 1110693004092 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1110693004093 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1110693004094 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1110693004095 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1110693004096 Walker A/P-loop; other site 1110693004097 ATP binding site [chemical binding]; other site 1110693004098 Q-loop/lid; other site 1110693004099 ABC transporter signature motif; other site 1110693004100 Walker B; other site 1110693004101 D-loop; other site 1110693004102 H-loop/switch region; other site 1110693004103 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1110693004104 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1110693004105 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1110693004106 TM-ABC transporter signature motif; other site 1110693004107 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1110693004108 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1110693004109 TM-ABC transporter signature motif; other site 1110693004110 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1110693004111 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1110693004112 ligand binding site [chemical binding]; other site 1110693004113 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1110693004114 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1110693004115 putative active site; other site 1110693004116 catalytic residue [active] 1110693004117 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1110693004118 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1110693004119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693004120 S-adenosylmethionine binding site [chemical binding]; other site 1110693004121 Predicted membrane protein [Function unknown]; Region: COG3781 1110693004122 altronate oxidoreductase; Provisional; Region: PRK03643 1110693004123 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1110693004124 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1110693004125 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1110693004126 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693004127 metal binding site [ion binding]; metal-binding site 1110693004128 active site 1110693004129 I-site; other site 1110693004130 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1110693004131 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1110693004132 glutaminase; Provisional; Region: PRK00971 1110693004133 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1110693004134 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1110693004135 NAD(P) binding site [chemical binding]; other site 1110693004136 catalytic residues [active] 1110693004137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1110693004138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693004139 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1110693004140 putative dimerization interface [polypeptide binding]; other site 1110693004141 putative arabinose transporter; Provisional; Region: PRK03545 1110693004142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004143 putative substrate translocation pore; other site 1110693004144 inner membrane protein; Provisional; Region: PRK10995 1110693004145 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1110693004146 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1110693004147 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1110693004148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693004149 hypothetical protein; Provisional; Region: PRK10106 1110693004150 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1110693004151 EamA-like transporter family; Region: EamA; pfam00892 1110693004152 EamA-like transporter family; Region: EamA; pfam00892 1110693004153 putative transporter; Provisional; Region: PRK10054 1110693004154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004155 putative substrate translocation pore; other site 1110693004156 diguanylate cyclase; Provisional; Region: PRK09894 1110693004157 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1110693004158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693004159 metal binding site [ion binding]; metal-binding site 1110693004160 active site 1110693004161 I-site; other site 1110693004162 hypothetical protein; Provisional; Region: PRK10053 1110693004163 hypothetical protein; Validated; Region: PRK03657 1110693004164 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1110693004165 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1110693004166 active site 1110693004167 Zn binding site [ion binding]; other site 1110693004168 putative oxidoreductase; Provisional; Region: PRK10083 1110693004169 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1110693004170 putative NAD(P) binding site [chemical binding]; other site 1110693004171 catalytic Zn binding site [ion binding]; other site 1110693004172 structural Zn binding site [ion binding]; other site 1110693004173 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1110693004174 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1110693004175 putative active site pocket [active] 1110693004176 putative metal binding site [ion binding]; other site 1110693004177 hypothetical protein; Provisional; Region: PRK02237 1110693004178 hypothetical protein; Provisional; Region: PRK13659 1110693004179 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1110693004180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1110693004181 Coenzyme A binding pocket [chemical binding]; other site 1110693004182 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1110693004183 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1110693004184 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1110693004185 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1110693004186 putative [Fe4-S4] binding site [ion binding]; other site 1110693004187 putative molybdopterin cofactor binding site [chemical binding]; other site 1110693004188 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1110693004189 putative molybdopterin cofactor binding site; other site 1110693004190 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1110693004191 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1110693004192 putative [Fe4-S4] binding site [ion binding]; other site 1110693004193 putative molybdopterin cofactor binding site [chemical binding]; other site 1110693004194 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1110693004195 putative molybdopterin cofactor binding site; other site 1110693004196 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1110693004197 4Fe-4S binding domain; Region: Fer4; cl02805 1110693004198 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1110693004199 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1110693004200 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1110693004201 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1110693004202 Cl- selectivity filter; other site 1110693004203 Cl- binding residues [ion binding]; other site 1110693004204 pore gating glutamate residue; other site 1110693004205 dimer interface [polypeptide binding]; other site 1110693004206 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1110693004207 AAA domain; Region: AAA_26; pfam13500 1110693004208 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1110693004209 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1110693004210 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1110693004211 nucleotide binding site [chemical binding]; other site 1110693004212 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1110693004213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693004214 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1110693004215 dimerization interface [polypeptide binding]; other site 1110693004216 substrate binding pocket [chemical binding]; other site 1110693004217 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1110693004218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004219 putative substrate translocation pore; other site 1110693004220 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1110693004221 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1110693004222 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1110693004223 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1110693004224 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1110693004225 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1110693004226 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1110693004227 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1110693004228 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1110693004229 ligand binding site [chemical binding]; other site 1110693004230 homodimer interface [polypeptide binding]; other site 1110693004231 NAD(P) binding site [chemical binding]; other site 1110693004232 trimer interface B [polypeptide binding]; other site 1110693004233 trimer interface A [polypeptide binding]; other site 1110693004234 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1110693004235 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1110693004236 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1110693004237 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1110693004238 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1110693004239 Spore germination protein; Region: Spore_permease; cl17796 1110693004240 dihydromonapterin reductase; Provisional; Region: PRK06483 1110693004241 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 1110693004242 NADP binding site [chemical binding]; other site 1110693004243 substrate binding pocket [chemical binding]; other site 1110693004244 active site 1110693004245 GlpM protein; Region: GlpM; pfam06942 1110693004246 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1110693004247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693004248 active site 1110693004249 phosphorylation site [posttranslational modification] 1110693004250 intermolecular recognition site; other site 1110693004251 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693004252 DNA binding site [nucleotide binding] 1110693004253 sensor protein RstB; Provisional; Region: PRK10604 1110693004254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1110693004255 dimerization interface [polypeptide binding]; other site 1110693004256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693004257 dimer interface [polypeptide binding]; other site 1110693004258 phosphorylation site [posttranslational modification] 1110693004259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693004260 ATP binding site [chemical binding]; other site 1110693004261 Mg2+ binding site [ion binding]; other site 1110693004262 G-X-G motif; other site 1110693004263 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1110693004264 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1110693004265 Class II fumarases; Region: Fumarase_classII; cd01362 1110693004266 active site 1110693004267 tetramer interface [polypeptide binding]; other site 1110693004268 fumarate hydratase; Provisional; Region: PRK15389 1110693004269 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1110693004270 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1110693004271 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1110693004272 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1110693004273 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1110693004274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1110693004275 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1110693004276 putative outer membrane porin protein; Provisional; Region: PRK11379 1110693004277 glucuronide transporter; Provisional; Region: PRK09848 1110693004278 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1110693004279 beta-D-glucuronidase; Provisional; Region: PRK10150 1110693004280 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1110693004281 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1110693004282 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1110693004283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1110693004284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1110693004285 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 1110693004286 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 1110693004287 NAD binding site [chemical binding]; other site 1110693004288 substrate binding site [chemical binding]; other site 1110693004289 homotetramer interface [polypeptide binding]; other site 1110693004290 homodimer interface [polypeptide binding]; other site 1110693004291 active site 1110693004292 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1110693004293 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693004294 DNA binding site [nucleotide binding] 1110693004295 domain linker motif; other site 1110693004296 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1110693004297 putative dimerization interface [polypeptide binding]; other site 1110693004298 putative ligand binding site [chemical binding]; other site 1110693004299 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1110693004300 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1110693004301 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1110693004302 active site turn [active] 1110693004303 phosphorylation site [posttranslational modification] 1110693004304 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1110693004305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1110693004306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693004307 homodimer interface [polypeptide binding]; other site 1110693004308 catalytic residue [active] 1110693004309 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1110693004310 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1110693004311 active site 1110693004312 purine riboside binding site [chemical binding]; other site 1110693004313 putative oxidoreductase; Provisional; Region: PRK11579 1110693004314 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1110693004315 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1110693004316 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1110693004317 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1110693004318 electron transport complex protein RsxA; Provisional; Region: PRK05151 1110693004319 electron transport complex protein RnfB; Provisional; Region: PRK05113 1110693004320 Putative Fe-S cluster; Region: FeS; pfam04060 1110693004321 4Fe-4S binding domain; Region: Fer4; pfam00037 1110693004322 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1110693004323 SLBB domain; Region: SLBB; pfam10531 1110693004324 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1110693004325 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1110693004326 electron transport complex protein RnfG; Validated; Region: PRK01908 1110693004327 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1110693004328 endonuclease III; Provisional; Region: PRK10702 1110693004329 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1110693004330 minor groove reading motif; other site 1110693004331 helix-hairpin-helix signature motif; other site 1110693004332 substrate binding pocket [chemical binding]; other site 1110693004333 active site 1110693004334 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1110693004335 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1110693004336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004337 putative substrate translocation pore; other site 1110693004338 POT family; Region: PTR2; pfam00854 1110693004339 glutathionine S-transferase; Provisional; Region: PRK10542 1110693004340 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1110693004341 C-terminal domain interface [polypeptide binding]; other site 1110693004342 GSH binding site (G-site) [chemical binding]; other site 1110693004343 dimer interface [polypeptide binding]; other site 1110693004344 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1110693004345 N-terminal domain interface [polypeptide binding]; other site 1110693004346 dimer interface [polypeptide binding]; other site 1110693004347 substrate binding pocket (H-site) [chemical binding]; other site 1110693004348 pyridoxamine kinase; Validated; Region: PRK05756 1110693004349 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1110693004350 dimer interface [polypeptide binding]; other site 1110693004351 pyridoxal binding site [chemical binding]; other site 1110693004352 ATP binding site [chemical binding]; other site 1110693004353 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1110693004354 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1110693004355 active site 1110693004356 HIGH motif; other site 1110693004357 dimer interface [polypeptide binding]; other site 1110693004358 KMSKS motif; other site 1110693004359 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1110693004360 RNA binding surface [nucleotide binding]; other site 1110693004361 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1110693004362 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1110693004363 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1110693004364 lysozyme inhibitor; Provisional; Region: PRK11372 1110693004365 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1110693004366 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 1110693004367 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1110693004368 transcriptional regulator SlyA; Provisional; Region: PRK03573 1110693004369 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1110693004370 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 1110693004371 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1110693004372 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693004373 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693004374 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1110693004375 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1110693004376 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1110693004377 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1110693004378 E-class dimer interface [polypeptide binding]; other site 1110693004379 P-class dimer interface [polypeptide binding]; other site 1110693004380 active site 1110693004381 Cu2+ binding site [ion binding]; other site 1110693004382 Zn2+ binding site [ion binding]; other site 1110693004383 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1110693004384 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1110693004385 active site 1110693004386 catalytic tetrad [active] 1110693004387 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1110693004388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1110693004389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1110693004390 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1110693004391 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1110693004392 FMN binding site [chemical binding]; other site 1110693004393 active site 1110693004394 substrate binding site [chemical binding]; other site 1110693004395 catalytic residue [active] 1110693004396 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1110693004397 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1110693004398 dimer interface [polypeptide binding]; other site 1110693004399 active site 1110693004400 metal binding site [ion binding]; metal-binding site 1110693004401 glutathione binding site [chemical binding]; other site 1110693004402 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1110693004403 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1110693004404 dimer interface [polypeptide binding]; other site 1110693004405 catalytic site [active] 1110693004406 putative active site [active] 1110693004407 putative substrate binding site [chemical binding]; other site 1110693004408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1110693004409 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1110693004410 ATP binding site [chemical binding]; other site 1110693004411 putative Mg++ binding site [ion binding]; other site 1110693004412 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1110693004413 nucleotide binding region [chemical binding]; other site 1110693004414 ATP-binding site [chemical binding]; other site 1110693004415 DEAD/H associated; Region: DEAD_assoc; pfam08494 1110693004416 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1110693004417 putative GSH binding site [chemical binding]; other site 1110693004418 catalytic residues [active] 1110693004419 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1110693004420 NlpC/P60 family; Region: NLPC_P60; pfam00877 1110693004421 superoxide dismutase; Provisional; Region: PRK10543 1110693004422 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1110693004423 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1110693004424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1110693004426 putative substrate translocation pore; other site 1110693004427 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1110693004428 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693004429 DNA binding site [nucleotide binding] 1110693004430 domain linker motif; other site 1110693004431 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1110693004432 dimerization interface [polypeptide binding]; other site 1110693004433 ligand binding site [chemical binding]; other site 1110693004434 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1110693004435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693004436 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1110693004437 dimerization interface [polypeptide binding]; other site 1110693004438 putative transporter; Provisional; Region: PRK11043 1110693004439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004440 putative substrate translocation pore; other site 1110693004441 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1110693004442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1110693004443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693004444 S-adenosylmethionine binding site [chemical binding]; other site 1110693004445 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1110693004446 Lumazine binding domain; Region: Lum_binding; pfam00677 1110693004447 Lumazine binding domain; Region: Lum_binding; pfam00677 1110693004448 multidrug efflux protein; Reviewed; Region: PRK01766 1110693004449 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1110693004450 cation binding site [ion binding]; other site 1110693004451 hypothetical protein; Provisional; Region: PRK09945 1110693004452 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 1110693004453 putative monooxygenase; Provisional; Region: PRK11118 1110693004454 hypothetical protein; Provisional; Region: PRK09897 1110693004455 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1110693004456 hypothetical protein; Provisional; Region: PRK09946 1110693004457 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 1110693004458 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1110693004459 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1110693004460 hypothetical protein; Provisional; Region: PRK09947 1110693004461 putative oxidoreductase; Provisional; Region: PRK09849 1110693004462 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 1110693004463 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1110693004464 hypothetical protein; Provisional; Region: PRK09898 1110693004465 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1110693004466 hypothetical protein; Provisional; Region: PRK10292 1110693004467 pyruvate kinase; Provisional; Region: PRK09206 1110693004468 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1110693004469 domain interfaces; other site 1110693004470 active site 1110693004471 murein lipoprotein; Provisional; Region: PRK15396 1110693004472 L,D-transpeptidase; Provisional; Region: PRK10190 1110693004473 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1110693004474 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1110693004475 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1110693004476 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1110693004477 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1110693004478 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1110693004479 catalytic residue [active] 1110693004480 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1110693004481 FeS assembly protein SufD; Region: sufD; TIGR01981 1110693004482 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1110693004483 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1110693004484 Walker A/P-loop; other site 1110693004485 ATP binding site [chemical binding]; other site 1110693004486 Q-loop/lid; other site 1110693004487 ABC transporter signature motif; other site 1110693004488 Walker B; other site 1110693004489 D-loop; other site 1110693004490 H-loop/switch region; other site 1110693004491 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1110693004492 putative ABC transporter; Region: ycf24; CHL00085 1110693004493 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1110693004494 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1110693004495 CoenzymeA binding site [chemical binding]; other site 1110693004496 subunit interaction site [polypeptide binding]; other site 1110693004497 PHB binding site; other site 1110693004498 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1110693004499 FAD binding domain; Region: FAD_binding_4; pfam01565 1110693004500 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1110693004501 putative inner membrane protein; Provisional; Region: PRK10983 1110693004502 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1110693004503 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 1110693004504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1110693004506 putative substrate translocation pore; other site 1110693004507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004508 putative substrate translocation pore; other site 1110693004509 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 1110693004510 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1110693004511 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1110693004512 shikimate binding site; other site 1110693004513 NAD(P) binding site [chemical binding]; other site 1110693004514 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1110693004515 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1110693004516 active site 1110693004517 catalytic residue [active] 1110693004518 dimer interface [polypeptide binding]; other site 1110693004519 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1110693004520 Coenzyme A transferase; Region: CoA_trans; smart00882 1110693004521 Coenzyme A transferase; Region: CoA_trans; cl17247 1110693004522 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1110693004523 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1110693004524 active site 1110693004525 Cupin domain; Region: Cupin_2; pfam07883 1110693004526 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 1110693004527 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1110693004528 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693004529 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1110693004530 Ligand binding site [chemical binding]; other site 1110693004531 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1110693004532 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 1110693004533 Electron transfer flavoprotein domain; Region: ETF; smart00893 1110693004534 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1110693004535 oxidoreductase; Provisional; Region: PRK10015 1110693004536 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1110693004537 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 1110693004538 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1110693004539 acyl-activating enzyme (AAE) consensus motif; other site 1110693004540 putative AMP binding site [chemical binding]; other site 1110693004541 putative active site [active] 1110693004542 putative CoA binding site [chemical binding]; other site 1110693004543 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1110693004544 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1110693004545 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1110693004546 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1110693004547 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1110693004548 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1110693004549 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1110693004550 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 1110693004551 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1110693004552 hypothetical protein; Validated; Region: PRK00029 1110693004553 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1110693004554 NlpC/P60 family; Region: NLPC_P60; pfam00877 1110693004555 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1110693004556 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1110693004557 Walker A/P-loop; other site 1110693004558 ATP binding site [chemical binding]; other site 1110693004559 Q-loop/lid; other site 1110693004560 ABC transporter signature motif; other site 1110693004561 Walker B; other site 1110693004562 D-loop; other site 1110693004563 H-loop/switch region; other site 1110693004564 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1110693004565 catalytic residues [active] 1110693004566 dimer interface [polypeptide binding]; other site 1110693004567 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1110693004568 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1110693004569 ABC-ATPase subunit interface; other site 1110693004570 dimer interface [polypeptide binding]; other site 1110693004571 putative PBP binding regions; other site 1110693004572 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1110693004573 IHF dimer interface [polypeptide binding]; other site 1110693004574 IHF - DNA interface [nucleotide binding]; other site 1110693004575 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1110693004576 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1110693004577 putative tRNA-binding site [nucleotide binding]; other site 1110693004578 B3/4 domain; Region: B3_4; pfam03483 1110693004579 tRNA synthetase B5 domain; Region: B5; smart00874 1110693004580 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1110693004581 dimer interface [polypeptide binding]; other site 1110693004582 motif 1; other site 1110693004583 motif 3; other site 1110693004584 motif 2; other site 1110693004585 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1110693004586 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1110693004587 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1110693004588 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1110693004589 dimer interface [polypeptide binding]; other site 1110693004590 motif 1; other site 1110693004591 active site 1110693004592 motif 2; other site 1110693004593 motif 3; other site 1110693004594 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1110693004595 23S rRNA binding site [nucleotide binding]; other site 1110693004596 L21 binding site [polypeptide binding]; other site 1110693004597 L13 binding site [polypeptide binding]; other site 1110693004598 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1110693004599 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1110693004600 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1110693004601 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1110693004602 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1110693004603 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1110693004604 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1110693004605 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1110693004606 active site 1110693004607 dimer interface [polypeptide binding]; other site 1110693004608 motif 1; other site 1110693004609 motif 2; other site 1110693004610 motif 3; other site 1110693004611 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1110693004612 anticodon binding site; other site 1110693004613 predicted protein, N-ter fragment (pseudogene) 1110693004614 predicted protein (pseudogene) 1110693004615 predicted protein, C-ter fragment (pseudogene) 1110693004616 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1110693004617 6-phosphofructokinase 2; Provisional; Region: PRK10294 1110693004618 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1110693004619 putative substrate binding site [chemical binding]; other site 1110693004620 putative ATP binding site [chemical binding]; other site 1110693004621 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1110693004622 Phosphotransferase enzyme family; Region: APH; pfam01636 1110693004623 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1110693004624 active site 1110693004625 ATP binding site [chemical binding]; other site 1110693004626 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1110693004627 YniB-like protein; Region: YniB; pfam14002 1110693004628 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1110693004629 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1110693004630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693004631 motif II; other site 1110693004632 inner membrane protein; Provisional; Region: PRK11648 1110693004633 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1110693004634 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1110693004635 cell division modulator; Provisional; Region: PRK10113 1110693004636 hydroperoxidase II; Provisional; Region: katE; PRK11249 1110693004637 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1110693004638 tetramer interface [polypeptide binding]; other site 1110693004639 heme binding pocket [chemical binding]; other site 1110693004640 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1110693004641 domain interactions; other site 1110693004642 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1110693004643 putative active site [active] 1110693004644 YdjC motif; other site 1110693004645 Mg binding site [ion binding]; other site 1110693004646 putative homodimer interface [polypeptide binding]; other site 1110693004647 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1110693004648 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1110693004649 NAD binding site [chemical binding]; other site 1110693004650 sugar binding site [chemical binding]; other site 1110693004651 divalent metal binding site [ion binding]; other site 1110693004652 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1110693004653 dimer interface [polypeptide binding]; other site 1110693004654 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1110693004655 Cupin domain; Region: Cupin_2; pfam07883 1110693004656 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693004657 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1110693004658 methionine cluster; other site 1110693004659 active site 1110693004660 phosphorylation site [posttranslational modification] 1110693004661 metal binding site [ion binding]; metal-binding site 1110693004662 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1110693004663 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1110693004664 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1110693004665 active site 1110693004666 P-loop; other site 1110693004667 phosphorylation site [posttranslational modification] 1110693004668 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1110693004669 NAD+ synthetase; Region: nadE; TIGR00552 1110693004670 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1110693004671 homodimer interface [polypeptide binding]; other site 1110693004672 NAD binding pocket [chemical binding]; other site 1110693004673 ATP binding pocket [chemical binding]; other site 1110693004674 Mg binding site [ion binding]; other site 1110693004675 active-site loop [active] 1110693004676 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1110693004677 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1110693004678 GIY-YIG motif/motif A; other site 1110693004679 active site 1110693004680 catalytic site [active] 1110693004681 putative DNA binding site [nucleotide binding]; other site 1110693004682 metal binding site [ion binding]; metal-binding site 1110693004683 hypothetical protein; Provisional; Region: PRK11396 1110693004684 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1110693004685 dimer interface [polypeptide binding]; other site 1110693004686 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1110693004687 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1110693004688 putative active site [active] 1110693004689 Zn binding site [ion binding]; other site 1110693004690 succinylarginine dihydrolase; Provisional; Region: PRK13281 1110693004691 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1110693004692 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1110693004693 NAD(P) binding site [chemical binding]; other site 1110693004694 catalytic residues [active] 1110693004695 arginine succinyltransferase; Provisional; Region: PRK10456 1110693004696 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1110693004697 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1110693004698 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1110693004699 inhibitor-cofactor binding pocket; inhibition site 1110693004700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693004701 catalytic residue [active] 1110693004702 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1110693004703 putative catalytic site [active] 1110693004704 putative phosphate binding site [ion binding]; other site 1110693004705 active site 1110693004706 metal binding site A [ion binding]; metal-binding site 1110693004707 DNA binding site [nucleotide binding] 1110693004708 putative AP binding site [nucleotide binding]; other site 1110693004709 putative metal binding site B [ion binding]; other site 1110693004710 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1110693004711 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1110693004712 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1110693004713 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1110693004714 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1110693004715 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1110693004716 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1110693004717 hypothetical protein; Provisional; Region: PRK11622 1110693004718 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 1110693004719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693004720 dimer interface [polypeptide binding]; other site 1110693004721 conserved gate region; other site 1110693004722 putative PBP binding loops; other site 1110693004723 ABC-ATPase subunit interface; other site 1110693004724 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1110693004725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693004726 Walker A/P-loop; other site 1110693004727 ATP binding site [chemical binding]; other site 1110693004728 Q-loop/lid; other site 1110693004729 ABC transporter signature motif; other site 1110693004730 Walker B; other site 1110693004731 D-loop; other site 1110693004732 H-loop/switch region; other site 1110693004733 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1110693004734 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1110693004735 active site residue [active] 1110693004736 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1110693004737 active site residue [active] 1110693004738 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1110693004739 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1110693004740 active site 1110693004741 8-oxo-dGMP binding site [chemical binding]; other site 1110693004742 nudix motif; other site 1110693004743 metal binding site [ion binding]; metal-binding site 1110693004744 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1110693004745 glutamate dehydrogenase; Provisional; Region: PRK09414 1110693004746 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1110693004747 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1110693004748 NAD(P) binding site [chemical binding]; other site 1110693004749 hypothetical protein; Provisional; Region: PRK11380 1110693004750 DNA topoisomerase III; Provisional; Region: PRK07726 1110693004751 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1110693004752 active site 1110693004753 putative interdomain interaction site [polypeptide binding]; other site 1110693004754 putative metal-binding site [ion binding]; other site 1110693004755 putative nucleotide binding site [chemical binding]; other site 1110693004756 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1110693004757 domain I; other site 1110693004758 DNA binding groove [nucleotide binding] 1110693004759 phosphate binding site [ion binding]; other site 1110693004760 domain II; other site 1110693004761 domain III; other site 1110693004762 nucleotide binding site [chemical binding]; other site 1110693004763 catalytic site [active] 1110693004764 domain IV; other site 1110693004765 selenophosphate synthetase; Provisional; Region: PRK00943 1110693004766 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1110693004767 dimerization interface [polypeptide binding]; other site 1110693004768 putative ATP binding site [chemical binding]; other site 1110693004769 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1110693004770 putative FMN binding site [chemical binding]; other site 1110693004771 protease 4; Provisional; Region: PRK10949 1110693004772 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1110693004773 tandem repeat interface [polypeptide binding]; other site 1110693004774 oligomer interface [polypeptide binding]; other site 1110693004775 active site residues [active] 1110693004776 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1110693004777 tandem repeat interface [polypeptide binding]; other site 1110693004778 oligomer interface [polypeptide binding]; other site 1110693004779 active site residues [active] 1110693004780 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1110693004781 active site 1110693004782 homodimer interface [polypeptide binding]; other site 1110693004783 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1110693004784 Isochorismatase family; Region: Isochorismatase; pfam00857 1110693004785 catalytic triad [active] 1110693004786 metal binding site [ion binding]; metal-binding site 1110693004787 conserved cis-peptide bond; other site 1110693004788 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1110693004789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004790 putative substrate translocation pore; other site 1110693004791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004792 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1110693004793 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1110693004794 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1110693004795 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1110693004796 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1110693004797 active site 1110693004798 catalytic tetrad [active] 1110693004799 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1110693004800 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1110693004801 substrate binding site [chemical binding]; other site 1110693004802 ATP binding site [chemical binding]; other site 1110693004803 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1110693004804 intersubunit interface [polypeptide binding]; other site 1110693004805 active site 1110693004806 zinc binding site [ion binding]; other site 1110693004807 Na+ binding site [ion binding]; other site 1110693004808 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1110693004809 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1110693004810 inhibitor binding site; inhibition site 1110693004811 catalytic Zn binding site [ion binding]; other site 1110693004812 structural Zn binding site [ion binding]; other site 1110693004813 NADP binding site [chemical binding]; other site 1110693004814 tetramer interface [polypeptide binding]; other site 1110693004815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004817 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1110693004818 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1110693004819 putative NAD(P) binding site [chemical binding]; other site 1110693004820 catalytic Zn binding site [ion binding]; other site 1110693004821 structural Zn binding site [ion binding]; other site 1110693004822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1110693004823 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1110693004824 SelR domain; Region: SelR; pfam01641 1110693004825 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1110693004826 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1110693004827 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1110693004828 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1110693004829 active site 1110693004830 phosphate binding residues; other site 1110693004831 catalytic residues [active] 1110693004832 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1110693004833 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1110693004834 active site 1110693004835 catalytic tetrad [active] 1110693004836 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1110693004837 PrkA family serine protein kinase; Provisional; Region: PRK15455 1110693004838 AAA ATPase domain; Region: AAA_16; pfam13191 1110693004839 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1110693004840 hypothetical protein; Provisional; Region: PRK05325 1110693004841 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1110693004842 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693004843 metal binding site [ion binding]; metal-binding site 1110693004844 active site 1110693004845 I-site; other site 1110693004846 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1110693004847 putative deacylase active site [active] 1110693004848 Predicted membrane protein [Function unknown]; Region: COG2707 1110693004849 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1110693004850 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693004851 cyanate transporter; Region: CynX; TIGR00896 1110693004852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004853 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1110693004854 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1110693004855 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1110693004856 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1110693004857 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1110693004858 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1110693004859 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1110693004860 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693004861 metal binding site [ion binding]; metal-binding site 1110693004862 active site 1110693004863 I-site; other site 1110693004864 hypothetical protein; Provisional; Region: PRK10457 1110693004865 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1110693004866 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1110693004867 leucine export protein LeuE; Provisional; Region: PRK10958 1110693004868 transcriptional activator TtdR; Provisional; Region: PRK09801 1110693004869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693004870 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1110693004871 putative effector binding pocket; other site 1110693004872 putative dimerization interface [polypeptide binding]; other site 1110693004873 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1110693004874 tartrate dehydrogenase; Region: TTC; TIGR02089 1110693004875 putative transporter; Provisional; Region: PRK09950 1110693004876 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1110693004877 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1110693004878 [2Fe-2S] cluster binding site [ion binding]; other site 1110693004879 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 1110693004880 putative alpha subunit interface [polypeptide binding]; other site 1110693004881 putative active site [active] 1110693004882 putative substrate binding site [chemical binding]; other site 1110693004883 Fe binding site [ion binding]; other site 1110693004884 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1110693004885 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1110693004886 FMN-binding pocket [chemical binding]; other site 1110693004887 flavin binding motif; other site 1110693004888 phosphate binding motif [ion binding]; other site 1110693004889 beta-alpha-beta structure motif; other site 1110693004890 NAD binding pocket [chemical binding]; other site 1110693004891 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1110693004892 catalytic loop [active] 1110693004893 iron binding site [ion binding]; other site 1110693004894 ribonuclease D; Provisional; Region: PRK10829 1110693004895 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1110693004896 catalytic site [active] 1110693004897 putative active site [active] 1110693004898 putative substrate binding site [chemical binding]; other site 1110693004899 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1110693004900 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1110693004901 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1110693004902 acyl-activating enzyme (AAE) consensus motif; other site 1110693004903 putative AMP binding site [chemical binding]; other site 1110693004904 putative active site [active] 1110693004905 putative CoA binding site [chemical binding]; other site 1110693004906 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 1110693004907 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1110693004908 Glycoprotease family; Region: Peptidase_M22; pfam00814 1110693004909 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1110693004910 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1110693004911 DEAD_2; Region: DEAD_2; pfam06733 1110693004912 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1110693004913 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1110693004914 homotrimer interaction site [polypeptide binding]; other site 1110693004915 putative active site [active] 1110693004916 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 1110693004917 hypothetical protein; Provisional; Region: PRK05114 1110693004918 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1110693004919 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1110693004920 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1110693004921 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1110693004922 putative active site [active] 1110693004923 putative CoA binding site [chemical binding]; other site 1110693004924 nudix motif; other site 1110693004925 metal binding site [ion binding]; metal-binding site 1110693004926 L-serine deaminase; Provisional; Region: PRK15023 1110693004927 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1110693004928 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1110693004929 phage resistance protein; Provisional; Region: PRK10551 1110693004930 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1110693004931 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1110693004932 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1110693004933 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1110693004934 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1110693004935 Transporter associated domain; Region: CorC_HlyC; smart01091 1110693004936 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1110693004937 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1110693004938 active pocket/dimerization site; other site 1110693004939 active site 1110693004940 phosphorylation site [posttranslational modification] 1110693004941 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1110693004942 active site 1110693004943 phosphorylation site [posttranslational modification] 1110693004944 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1110693004945 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1110693004946 Predicted membrane protein [Function unknown]; Region: COG4811 1110693004947 hypothetical protein; Provisional; Region: PRK11469 1110693004948 Domain of unknown function DUF; Region: DUF204; pfam02659 1110693004949 Domain of unknown function DUF; Region: DUF204; pfam02659 1110693004950 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1110693004951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693004952 S-adenosylmethionine binding site [chemical binding]; other site 1110693004953 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1110693004954 DNA-binding site [nucleotide binding]; DNA binding site 1110693004955 RNA-binding motif; other site 1110693004956 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 1110693004957 YebO-like protein; Region: YebO; pfam13974 1110693004958 PhoPQ regulatory protein; Provisional; Region: PRK10299 1110693004959 YobH-like protein; Region: YobH; pfam13996 1110693004960 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1110693004961 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1110693004962 dimerization interface [polypeptide binding]; other site 1110693004963 putative Zn2+ binding site [ion binding]; other site 1110693004964 putative DNA binding site [nucleotide binding]; other site 1110693004965 Bacterial transcriptional regulator; Region: IclR; pfam01614 1110693004966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693004967 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1110693004968 putative substrate translocation pore; other site 1110693004969 Predicted integral membrane protein [Function unknown]; Region: COG5521 1110693004970 heat shock protein HtpX; Provisional; Region: PRK05457 1110693004971 carboxy-terminal protease; Provisional; Region: PRK11186 1110693004972 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1110693004973 protein binding site [polypeptide binding]; other site 1110693004974 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1110693004975 Catalytic dyad [active] 1110693004976 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1110693004977 ProP expression regulator; Provisional; Region: PRK04950 1110693004978 ProQ/FINO family; Region: ProQ; pfam04352 1110693004979 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1110693004980 GAF domain; Region: GAF_2; pfam13185 1110693004981 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 1110693004982 Paraquat-inducible protein A; Region: PqiA; pfam04403 1110693004983 Paraquat-inducible protein A; Region: PqiA; pfam04403 1110693004984 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1110693004985 mce related protein; Region: MCE; pfam02470 1110693004986 mce related protein; Region: MCE; pfam02470 1110693004987 mce related protein; Region: MCE; pfam02470 1110693004988 mce related protein; Region: MCE; pfam02470 1110693004989 mce related protein; Region: MCE; pfam02470 1110693004990 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1110693004991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693004992 S-adenosylmethionine binding site [chemical binding]; other site 1110693004993 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1110693004994 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1110693004995 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1110693004996 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 1110693004997 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1110693004998 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1110693004999 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1110693005000 hypothetical protein; Provisional; Region: PRK10301 1110693005001 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1110693005002 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1110693005003 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 1110693005004 exodeoxyribonuclease X; Provisional; Region: PRK07983 1110693005005 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1110693005006 active site 1110693005007 catalytic site [active] 1110693005008 substrate binding site [chemical binding]; other site 1110693005009 protease 2; Provisional; Region: PRK10115 1110693005010 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1110693005011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1110693005012 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1110693005013 putative metal binding site [ion binding]; other site 1110693005014 hypothetical protein; Provisional; Region: PRK13680 1110693005015 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 1110693005016 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1110693005017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1110693005018 ATP-grasp domain; Region: ATP-grasp; pfam02222 1110693005019 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1110693005020 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1110693005021 active site 1110693005022 intersubunit interface [polypeptide binding]; other site 1110693005023 catalytic residue [active] 1110693005024 phosphogluconate dehydratase; Validated; Region: PRK09054 1110693005025 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1110693005026 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1110693005027 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1110693005028 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1110693005029 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1110693005030 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1110693005031 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1110693005032 putative active site [active] 1110693005033 pyruvate kinase; Provisional; Region: PRK05826 1110693005034 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1110693005035 domain interfaces; other site 1110693005036 active site 1110693005037 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1110693005038 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1110693005039 putative acyl-acceptor binding pocket; other site 1110693005040 putative peptidase; Provisional; Region: PRK11649 1110693005041 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1110693005042 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1110693005043 Peptidase family M23; Region: Peptidase_M23; pfam01551 1110693005044 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1110693005045 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1110693005046 metal binding site [ion binding]; metal-binding site 1110693005047 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1110693005048 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1110693005049 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1110693005050 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1110693005051 ABC-ATPase subunit interface; other site 1110693005052 dimer interface [polypeptide binding]; other site 1110693005053 putative PBP binding regions; other site 1110693005054 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1110693005055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693005056 Walker A motif; other site 1110693005057 ATP binding site [chemical binding]; other site 1110693005058 Walker B motif; other site 1110693005059 arginine finger; other site 1110693005060 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1110693005061 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1110693005062 RuvA N terminal domain; Region: RuvA_N; pfam01330 1110693005063 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1110693005064 hypothetical protein; Provisional; Region: PRK11470 1110693005065 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1110693005066 active site 1110693005067 putative DNA-binding cleft [nucleotide binding]; other site 1110693005068 dimer interface [polypeptide binding]; other site 1110693005069 hypothetical protein; Validated; Region: PRK00110 1110693005070 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1110693005071 nudix motif; other site 1110693005072 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1110693005073 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1110693005074 dimer interface [polypeptide binding]; other site 1110693005075 anticodon binding site; other site 1110693005076 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1110693005077 homodimer interface [polypeptide binding]; other site 1110693005078 motif 1; other site 1110693005079 active site 1110693005080 motif 2; other site 1110693005081 GAD domain; Region: GAD; pfam02938 1110693005082 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1110693005083 motif 3; other site 1110693005084 Isochorismatase family; Region: Isochorismatase; pfam00857 1110693005085 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1110693005086 catalytic triad [active] 1110693005087 conserved cis-peptide bond; other site 1110693005088 hypothetical protein; Provisional; Region: PRK10302 1110693005089 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1110693005090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693005091 S-adenosylmethionine binding site [chemical binding]; other site 1110693005092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693005093 S-adenosylmethionine binding site [chemical binding]; other site 1110693005094 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1110693005095 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1110693005096 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1110693005097 molybdopterin cofactor binding site [chemical binding]; other site 1110693005098 substrate binding site [chemical binding]; other site 1110693005099 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1110693005100 molybdopterin cofactor binding site; other site 1110693005101 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 1110693005102 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1110693005103 copper homeostasis protein CutC; Provisional; Region: PRK11572 1110693005104 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1110693005105 putative metal binding site [ion binding]; other site 1110693005106 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1110693005107 arginyl-tRNA synthetase; Region: argS; TIGR00456 1110693005108 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1110693005109 active site 1110693005110 HIGH motif; other site 1110693005111 KMSK motif region; other site 1110693005112 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1110693005113 tRNA binding surface [nucleotide binding]; other site 1110693005114 anticodon binding site; other site 1110693005115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1110693005116 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1110693005117 Ligand Binding Site [chemical binding]; other site 1110693005118 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1110693005119 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1110693005120 active site 1110693005121 homotetramer interface [polypeptide binding]; other site 1110693005122 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1110693005123 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1110693005124 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1110693005125 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1110693005126 TM-ABC transporter signature motif; other site 1110693005127 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1110693005128 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1110693005129 Walker A/P-loop; other site 1110693005130 ATP binding site [chemical binding]; other site 1110693005131 Q-loop/lid; other site 1110693005132 ABC transporter signature motif; other site 1110693005133 Walker B; other site 1110693005134 D-loop; other site 1110693005135 H-loop/switch region; other site 1110693005136 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1110693005137 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1110693005138 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1110693005139 ligand binding site [chemical binding]; other site 1110693005140 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1110693005141 Ferritin-like domain; Region: Ferritin; pfam00210 1110693005142 ferroxidase diiron center [ion binding]; other site 1110693005143 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1110693005144 YecR-like lipoprotein; Region: YecR; pfam13992 1110693005145 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1110693005146 Ferritin-like domain; Region: Ferritin; pfam00210 1110693005147 ferroxidase diiron center [ion binding]; other site 1110693005148 probable metal-binding protein; Region: matur_matur; TIGR03853 1110693005149 tyrosine transporter TyrP; Provisional; Region: PRK15132 1110693005150 aromatic amino acid transport protein; Region: araaP; TIGR00837 1110693005151 hypothetical protein; Provisional; Region: PRK10396 1110693005152 yecA family protein; Region: ygfB_yecA; TIGR02292 1110693005153 SEC-C motif; Region: SEC-C; pfam02810 1110693005154 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1110693005155 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1110693005156 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1110693005157 GIY-YIG motif/motif A; other site 1110693005158 active site 1110693005159 catalytic site [active] 1110693005160 putative DNA binding site [nucleotide binding]; other site 1110693005161 metal binding site [ion binding]; metal-binding site 1110693005162 UvrB/uvrC motif; Region: UVR; pfam02151 1110693005163 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1110693005164 Helix-hairpin-helix motif; Region: HHH; pfam00633 1110693005165 response regulator; Provisional; Region: PRK09483 1110693005166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693005167 active site 1110693005168 phosphorylation site [posttranslational modification] 1110693005169 intermolecular recognition site; other site 1110693005170 dimerization interface [polypeptide binding]; other site 1110693005171 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693005172 DNA binding residues [nucleotide binding] 1110693005173 dimerization interface [polypeptide binding]; other site 1110693005174 hypothetical protein; Provisional; Region: PRK10613 1110693005175 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1110693005176 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1110693005177 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693005178 DNA binding residues [nucleotide binding] 1110693005179 dimerization interface [polypeptide binding]; other site 1110693005180 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1110693005181 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693005182 DNA binding residues [nucleotide binding] 1110693005183 dimerization interface [polypeptide binding]; other site 1110693005184 hypothetical protein; Provisional; Region: PRK10708 1110693005185 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1110693005186 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1110693005187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693005188 active site 1110693005189 motif I; other site 1110693005190 motif II; other site 1110693005191 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1110693005192 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693005193 metal binding site [ion binding]; metal-binding site 1110693005194 active site 1110693005195 I-site; other site 1110693005196 Uncharacterized small protein [Function unknown]; Region: COG5475 1110693005197 hypothetical protein; Provisional; Region: PRK10062 1110693005198 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1110693005199 EamA-like transporter family; Region: EamA; pfam00892 1110693005200 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1110693005201 additional DNA contacts [nucleotide binding]; other site 1110693005202 mismatch recognition site; other site 1110693005203 active site 1110693005204 zinc binding site [ion binding]; other site 1110693005205 DNA intercalation site [nucleotide binding]; other site 1110693005206 DNA cytosine methylase; Provisional; Region: PRK10458 1110693005207 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1110693005208 cofactor binding site; other site 1110693005209 DNA binding site [nucleotide binding] 1110693005210 substrate interaction site [chemical binding]; other site 1110693005211 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1110693005212 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1110693005213 Zn2+ binding site [ion binding]; other site 1110693005214 Mg2+ binding site [ion binding]; other site 1110693005215 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1110693005216 predicted protein, N-ter fragment (pseudogene) 1110693005217 predicted protein (pseudogene) 1110693005218 predicted protein, middle fragment (pseudogene) 1110693005219 predicted protein, C-ter fragment (pseudogene) 1110693005220 chaperone protein HchA; Provisional; Region: PRK04155 1110693005221 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 1110693005222 dimer interface [polypeptide binding]; other site 1110693005223 metal binding site [ion binding]; metal-binding site 1110693005224 potential oxyanion hole; other site 1110693005225 potential catalytic triad [active] 1110693005226 conserved cys residue [active] 1110693005227 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1110693005228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693005229 dimer interface [polypeptide binding]; other site 1110693005230 phosphorylation site [posttranslational modification] 1110693005231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693005232 ATP binding site [chemical binding]; other site 1110693005233 Mg2+ binding site [ion binding]; other site 1110693005234 G-X-G motif; other site 1110693005235 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 1110693005236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693005237 active site 1110693005238 phosphorylation site [posttranslational modification] 1110693005239 intermolecular recognition site; other site 1110693005240 dimerization interface [polypeptide binding]; other site 1110693005241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693005242 DNA binding site [nucleotide binding] 1110693005243 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1110693005244 active site 1110693005245 homotetramer interface [polypeptide binding]; other site 1110693005246 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1110693005247 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1110693005248 Moco binding site; other site 1110693005249 metal coordination site [ion binding]; other site 1110693005250 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1110693005251 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1110693005252 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1110693005253 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1110693005254 putative invasin; Provisional; Region: PRK10177 1110693005255 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1110693005256 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1110693005257 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1110693005258 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1110693005259 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1110693005260 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1110693005261 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1110693005262 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1110693005263 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1110693005264 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1110693005265 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1110693005266 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1110693005267 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1110693005268 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1110693005269 predicted protein, C-ter fragment (pseudogene) 1110693005270 predicted protein (pseudogene) 1110693005271 predicted protein, N-ter fragment (pseudogene) 1110693005272 shikimate transporter; Provisional; Region: PRK09952 1110693005273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693005274 putative substrate translocation pore; other site 1110693005275 AMP nucleosidase; Provisional; Region: PRK08292 1110693005276 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1110693005277 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1110693005278 hypothetical protein; Provisional; Region: PRK12378 1110693005279 MATE family multidrug exporter; Provisional; Region: PRK10189 1110693005280 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1110693005281 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1110693005282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693005283 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 1110693005284 putative substrate binding site [chemical binding]; other site 1110693005285 dimerization interface [polypeptide binding]; other site 1110693005286 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1110693005287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693005288 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1110693005289 putative dimerization interface [polypeptide binding]; other site 1110693005290 L,D-transpeptidase; Provisional; Region: PRK10190 1110693005291 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1110693005292 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1110693005293 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1110693005294 putative dimer interface [polypeptide binding]; other site 1110693005295 active site pocket [active] 1110693005296 putative cataytic base [active] 1110693005297 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 1110693005298 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1110693005299 homotrimer interface [polypeptide binding]; other site 1110693005300 Walker A motif; other site 1110693005301 GTP binding site [chemical binding]; other site 1110693005302 Walker B motif; other site 1110693005303 DNA gyrase inhibitor; Provisional; Region: PRK10016 1110693005304 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1110693005305 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1110693005306 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1110693005307 exonuclease I; Provisional; Region: sbcB; PRK11779 1110693005308 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1110693005309 active site 1110693005310 catalytic site [active] 1110693005311 substrate binding site [chemical binding]; other site 1110693005312 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1110693005313 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1110693005314 CPxP motif; other site 1110693005315 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1110693005316 Sulphur transport; Region: Sulf_transp; pfam04143 1110693005317 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1110693005318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693005319 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1110693005320 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1110693005321 dimerization interface [polypeptide binding]; other site 1110693005322 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1110693005323 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1110693005324 putative NAD(P) binding site [chemical binding]; other site 1110693005325 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1110693005326 antitoxin YefM; Provisional; Region: PRK11409 1110693005327 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1110693005328 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1110693005329 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1110693005330 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1110693005331 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1110693005332 NAD binding site [chemical binding]; other site 1110693005333 dimerization interface [polypeptide binding]; other site 1110693005334 product binding site; other site 1110693005335 substrate binding site [chemical binding]; other site 1110693005336 zinc binding site [ion binding]; other site 1110693005337 catalytic residues [active] 1110693005338 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1110693005339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1110693005340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693005341 homodimer interface [polypeptide binding]; other site 1110693005342 catalytic residue [active] 1110693005343 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1110693005344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693005345 active site 1110693005346 motif I; other site 1110693005347 motif II; other site 1110693005348 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1110693005349 putative active site pocket [active] 1110693005350 4-fold oligomerization interface [polypeptide binding]; other site 1110693005351 metal binding residues [ion binding]; metal-binding site 1110693005352 3-fold/trimer interface [polypeptide binding]; other site 1110693005353 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1110693005354 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1110693005355 putative active site [active] 1110693005356 oxyanion strand; other site 1110693005357 catalytic triad [active] 1110693005358 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1110693005359 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1110693005360 catalytic residues [active] 1110693005361 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1110693005362 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1110693005363 substrate binding site [chemical binding]; other site 1110693005364 glutamase interaction surface [polypeptide binding]; other site 1110693005365 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1110693005366 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1110693005367 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1110693005368 metal binding site [ion binding]; metal-binding site 1110693005369 chain length determinant protein WzzB; Provisional; Region: PRK15471 1110693005370 Chain length determinant protein; Region: Wzz; pfam02706 1110693005371 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1110693005372 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1110693005373 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1110693005374 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1110693005375 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1110693005376 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1110693005377 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1110693005378 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1110693005379 FOG: CBS domain [General function prediction only]; Region: COG0517 1110693005380 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1110693005381 Transporter associated domain; Region: CorC_HlyC; smart01091 1110693005382 putative assembly protein; Provisional; Region: PRK10833 1110693005383 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1110693005384 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1110693005385 trimer interface [polypeptide binding]; other site 1110693005386 active site 1110693005387 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1110693005388 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1110693005389 ATP-binding site [chemical binding]; other site 1110693005390 Sugar specificity; other site 1110693005391 Pyrimidine base specificity; other site 1110693005392 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1110693005393 putative diguanylate cyclase; Provisional; Region: PRK09776 1110693005394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1110693005395 putative active site [active] 1110693005396 heme pocket [chemical binding]; other site 1110693005397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1110693005398 putative active site [active] 1110693005399 heme pocket [chemical binding]; other site 1110693005400 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1110693005401 putative active site [active] 1110693005402 heme pocket [chemical binding]; other site 1110693005403 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693005404 metal binding site [ion binding]; metal-binding site 1110693005405 active site 1110693005406 I-site; other site 1110693005407 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1110693005408 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1110693005409 AlkA N-terminal domain; Region: AlkA_N; smart01009 1110693005410 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1110693005411 minor groove reading motif; other site 1110693005412 helix-hairpin-helix signature motif; other site 1110693005413 substrate binding pocket [chemical binding]; other site 1110693005414 active site 1110693005415 putative chaperone; Provisional; Region: PRK11678 1110693005416 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1110693005417 nucleotide binding site [chemical binding]; other site 1110693005418 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1110693005419 SBD interface [polypeptide binding]; other site 1110693005420 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 1110693005421 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1110693005422 substrate binding site [chemical binding]; other site 1110693005423 activation loop (A-loop); other site 1110693005424 Y-family of DNA polymerases; Region: PolY; cl12025 1110693005425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 1110693005426 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 1110693005427 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1110693005428 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 1110693005429 metal ion-dependent adhesion site (MIDAS); other site 1110693005430 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1110693005431 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693005432 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693005433 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1110693005434 Protein export membrane protein; Region: SecD_SecF; cl14618 1110693005435 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1110693005436 putative transporter; Provisional; Region: PRK10504 1110693005437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693005438 putative substrate translocation pore; other site 1110693005439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693005440 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1110693005441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1110693005442 dimerization interface [polypeptide binding]; other site 1110693005443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693005444 dimer interface [polypeptide binding]; other site 1110693005445 phosphorylation site [posttranslational modification] 1110693005446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693005447 ATP binding site [chemical binding]; other site 1110693005448 Mg2+ binding site [ion binding]; other site 1110693005449 G-X-G motif; other site 1110693005450 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1110693005451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693005452 active site 1110693005453 phosphorylation site [posttranslational modification] 1110693005454 intermolecular recognition site; other site 1110693005455 dimerization interface [polypeptide binding]; other site 1110693005456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693005457 DNA binding site [nucleotide binding] 1110693005458 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1110693005459 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1110693005460 putative active site; other site 1110693005461 catalytic residue [active] 1110693005462 nucleoside transporter; Region: 2A0110; TIGR00889 1110693005463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693005464 putative substrate translocation pore; other site 1110693005465 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1110693005466 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1110693005467 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 1110693005468 substrate binding site [chemical binding]; other site 1110693005469 ATP binding site [chemical binding]; other site 1110693005470 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1110693005471 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693005472 DNA-binding site [nucleotide binding]; DNA binding site 1110693005473 UTRA domain; Region: UTRA; pfam07702 1110693005474 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1110693005475 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 1110693005476 active site 1110693005477 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1110693005478 dimer interface [polypeptide binding]; other site 1110693005479 substrate binding site [chemical binding]; other site 1110693005480 ATP binding site [chemical binding]; other site 1110693005481 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1110693005482 substrate binding site [chemical binding]; other site 1110693005483 multimerization interface [polypeptide binding]; other site 1110693005484 ATP binding site [chemical binding]; other site 1110693005485 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1110693005486 putative metal binding site [ion binding]; other site 1110693005487 putative homodimer interface [polypeptide binding]; other site 1110693005488 putative homotetramer interface [polypeptide binding]; other site 1110693005489 putative homodimer-homodimer interface [polypeptide binding]; other site 1110693005490 putative allosteric switch controlling residues; other site 1110693005491 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1110693005492 Predicted integral membrane protein [Function unknown]; Region: COG5455 1110693005493 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 1110693005494 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 1110693005495 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 1110693005496 PapC N-terminal domain; Region: PapC_N; pfam13954 1110693005497 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1110693005498 PapC C-terminal domain; Region: PapC_C; pfam13953 1110693005499 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 1110693005500 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1110693005501 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1110693005502 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1110693005503 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 1110693005504 antiporter inner membrane protein; Provisional; Region: PRK11670 1110693005505 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1110693005506 Walker A motif; other site 1110693005507 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1110693005508 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1110693005509 active site 1110693005510 HIGH motif; other site 1110693005511 KMSKS motif; other site 1110693005512 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1110693005513 tRNA binding surface [nucleotide binding]; other site 1110693005514 anticodon binding site; other site 1110693005515 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1110693005516 dimer interface [polypeptide binding]; other site 1110693005517 putative tRNA-binding site [nucleotide binding]; other site 1110693005518 DNA-binding transcriptional regulator, N-ter fragment (pseudogene) 1110693005519 DNA-binding transcriptional regulator (pseudogene) 1110693005520 DNA-binding transcriptional regulator, middle fragment (pseudogene) 1110693005521 DNA-binding transcriptional regulator, C-ter fragment (pseudogene) 1110693005522 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1110693005523 MoxR-like ATPases [General function prediction only]; Region: COG0714 1110693005524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693005525 Walker A motif; other site 1110693005526 ATP binding site [chemical binding]; other site 1110693005527 Walker B motif; other site 1110693005528 arginine finger; other site 1110693005529 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1110693005530 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1110693005531 metal ion-dependent adhesion site (MIDAS); other site 1110693005532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1110693005533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1110693005534 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1110693005535 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1110693005536 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1110693005537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693005538 active site 1110693005539 phosphorylation site [posttranslational modification] 1110693005540 intermolecular recognition site; other site 1110693005541 dimerization interface [polypeptide binding]; other site 1110693005542 LytTr DNA-binding domain; Region: LytTR; pfam04397 1110693005543 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1110693005544 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1110693005545 GAF domain; Region: GAF; pfam01590 1110693005546 Histidine kinase; Region: His_kinase; pfam06580 1110693005547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693005548 ATP binding site [chemical binding]; other site 1110693005549 Mg2+ binding site [ion binding]; other site 1110693005550 G-X-G motif; other site 1110693005551 transcriptional regulator MirA; Provisional; Region: PRK15043 1110693005552 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1110693005553 DNA binding residues [nucleotide binding] 1110693005554 hypothetical protein; Provisional; Region: PRK13681 1110693005555 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1110693005556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693005557 dimer interface [polypeptide binding]; other site 1110693005558 conserved gate region; other site 1110693005559 putative PBP binding loops; other site 1110693005560 ABC-ATPase subunit interface; other site 1110693005561 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1110693005562 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1110693005563 Walker A/P-loop; other site 1110693005564 ATP binding site [chemical binding]; other site 1110693005565 Q-loop/lid; other site 1110693005566 ABC transporter signature motif; other site 1110693005567 Walker B; other site 1110693005568 D-loop; other site 1110693005569 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1110693005570 H-loop/switch region; other site 1110693005571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693005572 dimer interface [polypeptide binding]; other site 1110693005573 conserved gate region; other site 1110693005574 ABC-ATPase subunit interface; other site 1110693005575 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1110693005576 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1110693005577 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1110693005578 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1110693005579 D-lactate dehydrogenase; Provisional; Region: PRK11183 1110693005580 FAD binding domain; Region: FAD_binding_4; pfam01565 1110693005581 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1110693005582 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1110693005583 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1110693005584 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1110693005585 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1110693005586 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1110693005587 oxidoreductase; Provisional; Region: PRK12743 1110693005588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1110693005589 NAD(P) binding site [chemical binding]; other site 1110693005590 active site 1110693005591 Outer membrane efflux protein; Region: OEP; pfam02321 1110693005592 Outer membrane efflux protein; Region: OEP; pfam02321 1110693005593 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1110693005594 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1110693005595 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1110693005596 FMN binding site [chemical binding]; other site 1110693005597 active site 1110693005598 catalytic residues [active] 1110693005599 substrate binding site [chemical binding]; other site 1110693005600 hypothetical protein; Provisional; Region: PRK01821 1110693005601 hypothetical protein; Provisional; Region: PRK10711 1110693005602 cytidine deaminase; Provisional; Region: PRK09027 1110693005603 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1110693005604 active site 1110693005605 catalytic motif [active] 1110693005606 Zn binding site [ion binding]; other site 1110693005607 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1110693005608 active site 1110693005609 catalytic motif [active] 1110693005610 Zn binding site [ion binding]; other site 1110693005611 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1110693005612 putative active site [active] 1110693005613 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 1110693005614 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1110693005615 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1110693005616 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693005617 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1110693005618 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1110693005619 homodimer interface [polypeptide binding]; other site 1110693005620 active site 1110693005621 FMN binding site [chemical binding]; other site 1110693005622 substrate binding site [chemical binding]; other site 1110693005623 4Fe-4S binding domain; Region: Fer4; pfam00037 1110693005624 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1110693005625 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1110693005626 TM-ABC transporter signature motif; other site 1110693005627 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1110693005628 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1110693005629 Walker A/P-loop; other site 1110693005630 ATP binding site [chemical binding]; other site 1110693005631 Q-loop/lid; other site 1110693005632 ABC transporter signature motif; other site 1110693005633 Walker B; other site 1110693005634 D-loop; other site 1110693005635 H-loop/switch region; other site 1110693005636 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1110693005637 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1110693005638 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1110693005639 ligand binding site [chemical binding]; other site 1110693005640 calcium binding site [ion binding]; other site 1110693005641 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1110693005642 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693005643 DNA binding site [nucleotide binding] 1110693005644 domain linker motif; other site 1110693005645 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1110693005646 dimerization interface (closed form) [polypeptide binding]; other site 1110693005647 ligand binding site [chemical binding]; other site 1110693005648 Predicted membrane protein [Function unknown]; Region: COG2311 1110693005649 hypothetical protein; Provisional; Region: PRK10835 1110693005650 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1110693005651 homodecamer interface [polypeptide binding]; other site 1110693005652 GTP cyclohydrolase I; Provisional; Region: PLN03044 1110693005653 active site 1110693005654 putative catalytic site residues [active] 1110693005655 zinc binding site [ion binding]; other site 1110693005656 GTP-CH-I/GFRP interaction surface; other site 1110693005657 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1110693005658 S-formylglutathione hydrolase; Region: PLN02442 1110693005659 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 1110693005660 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1110693005661 N-terminal plug; other site 1110693005662 ligand-binding site [chemical binding]; other site 1110693005663 lysine transporter; Provisional; Region: PRK10836 1110693005664 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1110693005665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693005666 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1110693005667 putative dimerization interface [polypeptide binding]; other site 1110693005668 conserved hypothetical integral membrane protein; Region: TIGR00698 1110693005669 endonuclease IV; Provisional; Region: PRK01060 1110693005670 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1110693005671 AP (apurinic/apyrimidinic) site pocket; other site 1110693005672 DNA interaction; other site 1110693005673 Metal-binding active site; metal-binding site 1110693005674 putative kinase; Provisional; Region: PRK09954 1110693005675 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1110693005676 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1110693005677 substrate binding site [chemical binding]; other site 1110693005678 ATP binding site [chemical binding]; other site 1110693005679 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1110693005680 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1110693005681 Nucleoside recognition; Region: Gate; pfam07670 1110693005682 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1110693005683 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1110693005684 active site 1110693005685 tetramer interface [polypeptide binding]; other site 1110693005686 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1110693005687 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1110693005688 ligand binding site [chemical binding]; other site 1110693005689 flexible hinge region; other site 1110693005690 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1110693005691 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1110693005692 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1110693005693 Nucleoside recognition; Region: Gate; pfam07670 1110693005694 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1110693005695 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1110693005696 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1110693005697 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1110693005698 substrate binding site [chemical binding]; other site 1110693005699 ATP binding site [chemical binding]; other site 1110693005700 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1110693005701 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1110693005702 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1110693005703 active site 1110693005704 P-loop; other site 1110693005705 phosphorylation site [posttranslational modification] 1110693005706 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1110693005707 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1110693005708 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1110693005709 putative substrate binding site [chemical binding]; other site 1110693005710 putative ATP binding site [chemical binding]; other site 1110693005711 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1110693005712 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1110693005713 active site 1110693005714 phosphorylation site [posttranslational modification] 1110693005715 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1110693005716 dimerization domain swap beta strand [polypeptide binding]; other site 1110693005717 regulatory protein interface [polypeptide binding]; other site 1110693005718 active site 1110693005719 regulatory phosphorylation site [posttranslational modification]; other site 1110693005720 sugar efflux transporter B; Provisional; Region: PRK15011 1110693005721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693005722 putative substrate translocation pore; other site 1110693005723 Flagellin N-methylase; Region: FliB; pfam03692 1110693005724 elongation factor P; Provisional; Region: PRK04542 1110693005725 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1110693005726 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1110693005727 RNA binding site [nucleotide binding]; other site 1110693005728 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1110693005729 RNA binding site [nucleotide binding]; other site 1110693005730 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1110693005731 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1110693005732 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1110693005733 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1110693005734 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1110693005735 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1110693005736 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1110693005737 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1110693005738 active site 1110693005739 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1110693005740 NlpC/P60 family; Region: NLPC_P60; pfam00877 1110693005741 phage resistance protein; Provisional; Region: PRK10551 1110693005742 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1110693005743 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1110693005744 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1110693005745 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1110693005746 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1110693005747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693005748 dimer interface [polypeptide binding]; other site 1110693005749 conserved gate region; other site 1110693005750 putative PBP binding loops; other site 1110693005751 ABC-ATPase subunit interface; other site 1110693005752 microcin C ABC transporter permease; Provisional; Region: PRK15021 1110693005753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693005754 dimer interface [polypeptide binding]; other site 1110693005755 conserved gate region; other site 1110693005756 ABC-ATPase subunit interface; other site 1110693005757 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1110693005758 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693005759 Walker A/P-loop; other site 1110693005760 ATP binding site [chemical binding]; other site 1110693005761 Q-loop/lid; other site 1110693005762 ABC transporter signature motif; other site 1110693005763 Walker B; other site 1110693005764 D-loop; other site 1110693005765 H-loop/switch region; other site 1110693005766 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1110693005767 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693005768 Walker A/P-loop; other site 1110693005769 ATP binding site [chemical binding]; other site 1110693005770 Q-loop/lid; other site 1110693005771 ABC transporter signature motif; other site 1110693005772 Walker B; other site 1110693005773 D-loop; other site 1110693005774 H-loop/switch region; other site 1110693005775 hypothetical protein; Provisional; Region: PRK11835 1110693005776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693005777 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1110693005778 putative substrate translocation pore; other site 1110693005779 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1110693005780 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1110693005781 RNA binding surface [nucleotide binding]; other site 1110693005782 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1110693005783 active site 1110693005784 uracil binding [chemical binding]; other site 1110693005785 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1110693005786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1110693005787 ATP binding site [chemical binding]; other site 1110693005788 putative Mg++ binding site [ion binding]; other site 1110693005789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1110693005790 nucleotide binding region [chemical binding]; other site 1110693005791 ATP-binding site [chemical binding]; other site 1110693005792 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 1110693005793 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1110693005794 5S rRNA interface [nucleotide binding]; other site 1110693005795 CTC domain interface [polypeptide binding]; other site 1110693005796 L16 interface [polypeptide binding]; other site 1110693005797 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1110693005798 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1110693005799 hypothetical protein; Provisional; Region: PRK13689 1110693005800 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1110693005801 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1110693005802 Sulfatase; Region: Sulfatase; pfam00884 1110693005803 transcriptional regulator NarP; Provisional; Region: PRK10403 1110693005804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693005805 active site 1110693005806 phosphorylation site [posttranslational modification] 1110693005807 intermolecular recognition site; other site 1110693005808 dimerization interface [polypeptide binding]; other site 1110693005809 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693005810 DNA binding residues [nucleotide binding] 1110693005811 dimerization interface [polypeptide binding]; other site 1110693005812 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1110693005813 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1110693005814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1110693005815 binding surface 1110693005816 TPR motif; other site 1110693005817 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1110693005818 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1110693005819 catalytic residues [active] 1110693005820 central insert; other site 1110693005821 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1110693005822 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1110693005823 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1110693005824 heme exporter protein CcmC; Region: ccmC; TIGR01191 1110693005825 heme exporter protein CcmB; Region: ccmB; TIGR01190 1110693005826 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1110693005827 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1110693005828 Walker A/P-loop; other site 1110693005829 ATP binding site [chemical binding]; other site 1110693005830 Q-loop/lid; other site 1110693005831 ABC transporter signature motif; other site 1110693005832 Walker B; other site 1110693005833 D-loop; other site 1110693005834 H-loop/switch region; other site 1110693005835 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1110693005836 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1110693005837 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1110693005838 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1110693005839 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1110693005840 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1110693005841 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1110693005842 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1110693005843 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1110693005844 [4Fe-4S] binding site [ion binding]; other site 1110693005845 molybdopterin cofactor binding site; other site 1110693005846 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1110693005847 molybdopterin cofactor binding site; other site 1110693005848 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1110693005849 ferredoxin-type protein; Provisional; Region: PRK10194 1110693005850 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1110693005851 secondary substrate binding site; other site 1110693005852 primary substrate binding site; other site 1110693005853 inhibition loop; other site 1110693005854 dimerization interface [polypeptide binding]; other site 1110693005855 malate:quinone oxidoreductase; Validated; Region: PRK05257 1110693005856 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1110693005857 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1110693005858 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1110693005859 Walker A/P-loop; other site 1110693005860 ATP binding site [chemical binding]; other site 1110693005861 Q-loop/lid; other site 1110693005862 ABC transporter signature motif; other site 1110693005863 Walker B; other site 1110693005864 D-loop; other site 1110693005865 H-loop/switch region; other site 1110693005866 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1110693005867 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1110693005868 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1110693005869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693005870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693005871 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1110693005872 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1110693005873 DNA binding site [nucleotide binding] 1110693005874 active site 1110693005875 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1110693005876 ApbE family; Region: ApbE; pfam02424 1110693005877 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1110693005878 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1110693005879 trimer interface [polypeptide binding]; other site 1110693005880 eyelet of channel; other site 1110693005881 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1110693005882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693005883 ATP binding site [chemical binding]; other site 1110693005884 G-X-G motif; other site 1110693005885 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1110693005886 putative binding surface; other site 1110693005887 active site 1110693005888 transcriptional regulator RcsB; Provisional; Region: PRK10840 1110693005889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693005890 active site 1110693005891 phosphorylation site [posttranslational modification] 1110693005892 intermolecular recognition site; other site 1110693005893 dimerization interface [polypeptide binding]; other site 1110693005894 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693005895 DNA binding residues [nucleotide binding] 1110693005896 dimerization interface [polypeptide binding]; other site 1110693005897 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1110693005898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693005899 dimer interface [polypeptide binding]; other site 1110693005900 phosphorylation site [posttranslational modification] 1110693005901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693005902 ATP binding site [chemical binding]; other site 1110693005903 Mg2+ binding site [ion binding]; other site 1110693005904 G-X-G motif; other site 1110693005905 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1110693005906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693005907 active site 1110693005908 phosphorylation site [posttranslational modification] 1110693005909 intermolecular recognition site; other site 1110693005910 dimerization interface [polypeptide binding]; other site 1110693005911 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1110693005912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1110693005913 putative active site [active] 1110693005914 heme pocket [chemical binding]; other site 1110693005915 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693005916 dimer interface [polypeptide binding]; other site 1110693005917 phosphorylation site [posttranslational modification] 1110693005918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693005919 ATP binding site [chemical binding]; other site 1110693005920 Mg2+ binding site [ion binding]; other site 1110693005921 G-X-G motif; other site 1110693005922 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 1110693005923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693005924 active site 1110693005925 phosphorylation site [posttranslational modification] 1110693005926 intermolecular recognition site; other site 1110693005927 dimerization interface [polypeptide binding]; other site 1110693005928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693005929 Walker A motif; other site 1110693005930 ATP binding site [chemical binding]; other site 1110693005931 Walker B motif; other site 1110693005932 arginine finger; other site 1110693005933 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1110693005934 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 1110693005935 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1110693005936 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 1110693005937 putative acyltransferase; Provisional; Region: PRK05790 1110693005938 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1110693005939 dimer interface [polypeptide binding]; other site 1110693005940 active site 1110693005941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1110693005942 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1110693005943 Predicted secreted protein [Function unknown]; Region: COG5445 1110693005944 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1110693005945 Predicted secreted protein [Function unknown]; Region: COG5445 1110693005946 Stage II sporulation protein; Region: SpoIID; pfam08486 1110693005947 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1110693005948 predicted protein, C-ter fragment (pseudogene) 1110693005949 predicted protein (pseudogene) 1110693005950 predicted protein, N-ter fragment (pseudogene) 1110693005951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 1110693005952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 1110693005953 DNA gyrase subunit A; Validated; Region: PRK05560 1110693005954 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1110693005955 CAP-like domain; other site 1110693005956 active site 1110693005957 primary dimer interface [polypeptide binding]; other site 1110693005958 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1110693005959 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1110693005960 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1110693005961 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1110693005962 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1110693005963 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1110693005964 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1110693005965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693005966 S-adenosylmethionine binding site [chemical binding]; other site 1110693005967 adhesin; Provisional; Region: PRK09752 1110693005968 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1110693005969 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1110693005970 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1110693005971 ATP cone domain; Region: ATP-cone; pfam03477 1110693005972 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1110693005973 active site 1110693005974 dimer interface [polypeptide binding]; other site 1110693005975 catalytic residues [active] 1110693005976 effector binding site; other site 1110693005977 R2 peptide binding site; other site 1110693005978 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1110693005979 dimer interface [polypeptide binding]; other site 1110693005980 putative radical transfer pathway; other site 1110693005981 diiron center [ion binding]; other site 1110693005982 tyrosyl radical; other site 1110693005983 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1110693005984 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1110693005985 catalytic loop [active] 1110693005986 iron binding site [ion binding]; other site 1110693005987 hypothetical protein; Provisional; Region: PRK09902 1110693005988 hypothetical protein; Provisional; Region: PRK09729 1110693005989 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1110693005990 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1110693005991 active site 1110693005992 catalytic site [active] 1110693005993 metal binding site [ion binding]; metal-binding site 1110693005994 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1110693005995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693005996 putative substrate translocation pore; other site 1110693005997 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1110693005998 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1110693005999 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1110693006000 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1110693006001 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1110693006002 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1110693006003 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1110693006004 Cysteine-rich domain; Region: CCG; pfam02754 1110693006005 Cysteine-rich domain; Region: CCG; pfam02754 1110693006006 hypothetical protein; Provisional; Region: PRK09956 1110693006007 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1110693006008 hypothetical protein; Provisional; Region: PRK09956 1110693006009 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 1110693006010 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1110693006011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693006012 putative substrate translocation pore; other site 1110693006013 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1110693006014 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1110693006015 putative active site pocket [active] 1110693006016 putative metal binding site [ion binding]; other site 1110693006017 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1110693006018 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1110693006019 Bacterial transcriptional regulator; Region: IclR; pfam01614 1110693006020 hypothetical protein; Provisional; Region: PRK03673 1110693006021 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1110693006022 putative MPT binding site; other site 1110693006023 Competence-damaged protein; Region: CinA; cl00666 1110693006024 YfaZ precursor; Region: YfaZ; pfam07437 1110693006025 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1110693006026 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1110693006027 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1110693006028 catalytic core [active] 1110693006029 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1110693006030 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1110693006031 inhibitor-cofactor binding pocket; inhibition site 1110693006032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693006033 catalytic residue [active] 1110693006034 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1110693006035 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1110693006036 Ligand binding site; other site 1110693006037 Putative Catalytic site; other site 1110693006038 DXD motif; other site 1110693006039 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1110693006040 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 1110693006041 substrate binding site [chemical binding]; other site 1110693006042 cosubstrate binding site; other site 1110693006043 catalytic site [active] 1110693006044 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1110693006045 active site 1110693006046 hexamer interface [polypeptide binding]; other site 1110693006047 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1110693006048 NAD binding site [chemical binding]; other site 1110693006049 substrate binding site [chemical binding]; other site 1110693006050 active site 1110693006051 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1110693006052 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1110693006053 putative active site [active] 1110693006054 putative catalytic site [active] 1110693006055 putative Zn binding site [ion binding]; other site 1110693006056 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1110693006057 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1110693006058 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1110693006059 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1110693006060 signal transduction protein PmrD; Provisional; Region: PRK15450 1110693006061 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1110693006062 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1110693006063 acyl-activating enzyme (AAE) consensus motif; other site 1110693006064 putative AMP binding site [chemical binding]; other site 1110693006065 putative active site [active] 1110693006066 putative CoA binding site [chemical binding]; other site 1110693006067 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1110693006068 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1110693006069 active site 1110693006070 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1110693006071 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1110693006072 substrate binding site [chemical binding]; other site 1110693006073 oxyanion hole (OAH) forming residues; other site 1110693006074 trimer interface [polypeptide binding]; other site 1110693006075 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1110693006076 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1110693006077 nucleophilic elbow; other site 1110693006078 catalytic triad; other site 1110693006079 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1110693006080 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1110693006081 dimer interface [polypeptide binding]; other site 1110693006082 tetramer interface [polypeptide binding]; other site 1110693006083 PYR/PP interface [polypeptide binding]; other site 1110693006084 TPP binding site [chemical binding]; other site 1110693006085 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1110693006086 TPP-binding site; other site 1110693006087 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1110693006088 isochorismate synthases; Region: isochor_syn; TIGR00543 1110693006089 hypothetical protein; Provisional; Region: PRK10404 1110693006090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1110693006091 Coenzyme A binding pocket [chemical binding]; other site 1110693006092 ribonuclease BN; Region: true_RNase_BN; TIGR02649 1110693006093 deubiquitinase; Provisional; Region: PRK11836 1110693006094 von Willebrand factor; Region: vWF_A; pfam12450 1110693006095 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1110693006096 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1110693006097 metal ion-dependent adhesion site (MIDAS); other site 1110693006098 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1110693006099 M28 Zn-Peptidases; Region: M28_like_1; cd05640 1110693006100 Peptidase family M28; Region: Peptidase_M28; pfam04389 1110693006101 metal binding site [ion binding]; metal-binding site 1110693006102 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1110693006103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1110693006104 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1110693006105 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1110693006106 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1110693006107 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1110693006108 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1110693006109 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1110693006110 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1110693006111 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1110693006112 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1110693006113 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1110693006114 4Fe-4S binding domain; Region: Fer4; pfam00037 1110693006115 4Fe-4S binding domain; Region: Fer4; pfam00037 1110693006116 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1110693006117 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1110693006118 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1110693006119 catalytic loop [active] 1110693006120 iron binding site [ion binding]; other site 1110693006121 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1110693006122 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1110693006123 [4Fe-4S] binding site [ion binding]; other site 1110693006124 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1110693006125 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1110693006126 SLBB domain; Region: SLBB; pfam10531 1110693006127 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1110693006128 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1110693006129 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1110693006130 putative dimer interface [polypeptide binding]; other site 1110693006131 [2Fe-2S] cluster binding site [ion binding]; other site 1110693006132 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1110693006133 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1110693006134 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1110693006135 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1110693006136 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1110693006137 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1110693006138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693006139 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1110693006140 putative dimerization interface [polypeptide binding]; other site 1110693006141 aminotransferase AlaT; Validated; Region: PRK09265 1110693006142 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1110693006143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693006144 homodimer interface [polypeptide binding]; other site 1110693006145 catalytic residue [active] 1110693006146 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1110693006147 Zn2+ binding site [ion binding]; other site 1110693006148 Mg2+ binding site [ion binding]; other site 1110693006149 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1110693006150 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1110693006151 TrkA-C domain; Region: TrkA_C; pfam02080 1110693006152 TrkA-C domain; Region: TrkA_C; pfam02080 1110693006153 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1110693006154 putative phosphatase; Provisional; Region: PRK11587 1110693006155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693006156 motif II; other site 1110693006157 hypothetical protein; Validated; Region: PRK05445 1110693006158 hypothetical protein; Provisional; Region: PRK01816 1110693006159 propionate/acetate kinase; Provisional; Region: PRK12379 1110693006160 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1110693006161 phosphate acetyltransferase; Reviewed; Region: PRK05632 1110693006162 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1110693006163 DRTGG domain; Region: DRTGG; pfam07085 1110693006164 phosphate acetyltransferase; Region: pta; TIGR00651 1110693006165 hypothetical protein; Provisional; Region: PRK11588 1110693006166 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1110693006167 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1110693006168 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1110693006169 nudix motif; other site 1110693006170 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1110693006171 active site 1110693006172 metal binding site [ion binding]; metal-binding site 1110693006173 homotetramer interface [polypeptide binding]; other site 1110693006174 glutathione S-transferase; Provisional; Region: PRK15113 1110693006175 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1110693006176 C-terminal domain interface [polypeptide binding]; other site 1110693006177 GSH binding site (G-site) [chemical binding]; other site 1110693006178 dimer interface [polypeptide binding]; other site 1110693006179 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1110693006180 N-terminal domain interface [polypeptide binding]; other site 1110693006181 putative dimer interface [polypeptide binding]; other site 1110693006182 putative substrate binding pocket (H-site) [chemical binding]; other site 1110693006183 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1110693006184 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1110693006185 C-terminal domain interface [polypeptide binding]; other site 1110693006186 GSH binding site (G-site) [chemical binding]; other site 1110693006187 dimer interface [polypeptide binding]; other site 1110693006188 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1110693006189 N-terminal domain interface [polypeptide binding]; other site 1110693006190 putative dimer interface [polypeptide binding]; other site 1110693006191 active site 1110693006192 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1110693006193 homooctamer interface [polypeptide binding]; other site 1110693006194 active site 1110693006195 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1110693006196 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1110693006197 putative NAD(P) binding site [chemical binding]; other site 1110693006198 putative active site [active] 1110693006199 putative transposase; Provisional; Region: PRK09857 1110693006200 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1110693006201 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1110693006202 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1110693006203 Walker A/P-loop; other site 1110693006204 ATP binding site [chemical binding]; other site 1110693006205 Q-loop/lid; other site 1110693006206 ABC transporter signature motif; other site 1110693006207 Walker B; other site 1110693006208 D-loop; other site 1110693006209 H-loop/switch region; other site 1110693006210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693006211 dimer interface [polypeptide binding]; other site 1110693006212 conserved gate region; other site 1110693006213 putative PBP binding loops; other site 1110693006214 ABC-ATPase subunit interface; other site 1110693006215 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1110693006216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693006217 dimer interface [polypeptide binding]; other site 1110693006218 conserved gate region; other site 1110693006219 putative PBP binding loops; other site 1110693006220 ABC-ATPase subunit interface; other site 1110693006221 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1110693006222 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693006223 substrate binding pocket [chemical binding]; other site 1110693006224 membrane-bound complex binding site; other site 1110693006225 hinge residues; other site 1110693006226 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1110693006227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693006228 substrate binding pocket [chemical binding]; other site 1110693006229 membrane-bound complex binding site; other site 1110693006230 hinge residues; other site 1110693006231 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1110693006232 Flavoprotein; Region: Flavoprotein; pfam02441 1110693006233 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1110693006234 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1110693006235 active site 1110693006236 tetramer interface [polypeptide binding]; other site 1110693006237 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1110693006238 active site 1110693006239 colicin V production protein; Provisional; Region: PRK10845 1110693006240 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1110693006241 cell division protein DedD; Provisional; Region: PRK11633 1110693006242 Sporulation related domain; Region: SPOR; pfam05036 1110693006243 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1110693006244 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1110693006245 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1110693006246 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1110693006247 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1110693006248 hypothetical protein; Provisional; Region: PRK10847 1110693006249 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1110693006250 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1110693006251 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1110693006252 dimerization interface 3.5A [polypeptide binding]; other site 1110693006253 active site 1110693006254 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1110693006255 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1110693006256 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1110693006257 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1110693006258 ligand binding site [chemical binding]; other site 1110693006259 NAD binding site [chemical binding]; other site 1110693006260 catalytic site [active] 1110693006261 homodimer interface [polypeptide binding]; other site 1110693006262 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1110693006263 putative transporter; Provisional; Region: PRK12382 1110693006264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693006265 putative substrate translocation pore; other site 1110693006266 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1110693006267 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1110693006268 dimer interface [polypeptide binding]; other site 1110693006269 active site 1110693006270 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1110693006271 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1110693006272 YfcL protein; Region: YfcL; pfam08891 1110693006273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1110693006274 hypothetical protein; Provisional; Region: PRK10621 1110693006275 Predicted permeases [General function prediction only]; Region: COG0730 1110693006276 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1110693006277 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1110693006278 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1110693006279 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1110693006280 Tetramer interface [polypeptide binding]; other site 1110693006281 active site 1110693006282 FMN-binding site [chemical binding]; other site 1110693006283 HemK family putative methylases; Region: hemK_fam; TIGR00536 1110693006284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693006285 S-adenosylmethionine binding site [chemical binding]; other site 1110693006286 hypothetical protein; Provisional; Region: PRK04946 1110693006287 Smr domain; Region: Smr; pfam01713 1110693006288 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 1110693006289 Fimbrial protein; Region: Fimbrial; cl01416 1110693006290 Fimbrial protein; Region: Fimbrial; cl01416 1110693006291 Fimbrial protein; Region: Fimbrial; cl01416 1110693006292 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1110693006293 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1110693006294 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1110693006295 PapC C-terminal domain; Region: PapC_C; pfam13953 1110693006296 PapC N-terminal domain; Region: PapC_N; pfam13954 1110693006297 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1110693006298 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1110693006299 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1110693006300 catalytic core [active] 1110693006301 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1110693006302 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1110693006303 substrate binding site [chemical binding]; other site 1110693006304 oxyanion hole (OAH) forming residues; other site 1110693006305 trimer interface [polypeptide binding]; other site 1110693006306 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1110693006307 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1110693006308 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1110693006309 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1110693006310 dimer interface [polypeptide binding]; other site 1110693006311 active site 1110693006312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1110693006313 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1110693006314 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1110693006315 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1110693006316 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1110693006317 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1110693006318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693006319 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1110693006320 dimerization interface [polypeptide binding]; other site 1110693006321 substrate binding pocket [chemical binding]; other site 1110693006322 permease DsdX; Provisional; Region: PRK09921 1110693006323 gluconate transporter; Region: gntP; TIGR00791 1110693006324 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1110693006325 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1110693006326 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1110693006327 catalytic residue [active] 1110693006328 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1110693006329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693006330 putative substrate translocation pore; other site 1110693006331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693006332 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1110693006333 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693006334 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693006335 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 1110693006336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693006337 active site 1110693006338 phosphorylation site [posttranslational modification] 1110693006339 intermolecular recognition site; other site 1110693006340 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693006341 DNA binding residues [nucleotide binding] 1110693006342 dimerization interface [polypeptide binding]; other site 1110693006343 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1110693006344 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693006345 substrate binding pocket [chemical binding]; other site 1110693006346 membrane-bound complex binding site; other site 1110693006347 hinge residues; other site 1110693006348 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693006349 substrate binding pocket [chemical binding]; other site 1110693006350 membrane-bound complex binding site; other site 1110693006351 hinge residues; other site 1110693006352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693006353 dimer interface [polypeptide binding]; other site 1110693006354 phosphorylation site [posttranslational modification] 1110693006355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693006356 ATP binding site [chemical binding]; other site 1110693006357 Mg2+ binding site [ion binding]; other site 1110693006358 G-X-G motif; other site 1110693006359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693006360 active site 1110693006361 phosphorylation site [posttranslational modification] 1110693006362 intermolecular recognition site; other site 1110693006363 dimerization interface [polypeptide binding]; other site 1110693006364 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1110693006365 putative binding surface; other site 1110693006366 active site 1110693006367 putative CoA-transferase; Provisional; Region: PRK11430 1110693006368 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1110693006369 putative transporter YfdV; Provisional; Region: PRK09903 1110693006370 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1110693006371 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1110693006372 PYR/PP interface [polypeptide binding]; other site 1110693006373 dimer interface [polypeptide binding]; other site 1110693006374 TPP binding site [chemical binding]; other site 1110693006375 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1110693006376 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1110693006377 TPP-binding site; other site 1110693006378 dimer interface [polypeptide binding]; other site 1110693006379 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1110693006380 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1110693006381 hypothetical protein; Provisional; Region: PRK10316 1110693006382 YfdX protein; Region: YfdX; pfam10938 1110693006383 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 1110693006384 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1110693006385 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1110693006386 putative acyl-acceptor binding pocket; other site 1110693006387 aminotransferase; Validated; Region: PRK08175 1110693006388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1110693006389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693006390 homodimer interface [polypeptide binding]; other site 1110693006391 catalytic residue [active] 1110693006392 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1110693006393 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1110693006394 GAF domain; Region: GAF; pfam01590 1110693006395 Histidine kinase; Region: His_kinase; pfam06580 1110693006396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693006397 ATP binding site [chemical binding]; other site 1110693006398 Mg2+ binding site [ion binding]; other site 1110693006399 G-X-G motif; other site 1110693006400 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1110693006401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693006402 active site 1110693006403 phosphorylation site [posttranslational modification] 1110693006404 intermolecular recognition site; other site 1110693006405 dimerization interface [polypeptide binding]; other site 1110693006406 LytTr DNA-binding domain; Region: LytTR; pfam04397 1110693006407 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1110693006408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693006409 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1110693006410 dimerization domain swap beta strand [polypeptide binding]; other site 1110693006411 regulatory protein interface [polypeptide binding]; other site 1110693006412 active site 1110693006413 regulatory phosphorylation site [posttranslational modification]; other site 1110693006414 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1110693006415 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1110693006416 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1110693006417 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1110693006418 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1110693006419 active site 1110693006420 phosphorylation site [posttranslational modification] 1110693006421 exoaminopeptidase; Provisional; Region: PRK09961 1110693006422 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 1110693006423 oligomer interface [polypeptide binding]; other site 1110693006424 active site 1110693006425 metal binding site [ion binding]; metal-binding site 1110693006426 aminopeptidase; Provisional; Region: PRK09795 1110693006427 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1110693006428 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1110693006429 active site 1110693006430 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1110693006431 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1110693006432 active site 1110693006433 P-loop; other site 1110693006434 phosphorylation site [posttranslational modification] 1110693006435 glucokinase, proteobacterial type; Region: glk; TIGR00749 1110693006436 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1110693006437 nucleotide binding site [chemical binding]; other site 1110693006438 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1110693006439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1110693006440 salt bridge; other site 1110693006441 non-specific DNA binding site [nucleotide binding]; other site 1110693006442 sequence-specific DNA binding site [nucleotide binding]; other site 1110693006443 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1110693006444 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1110693006445 active site 1110693006446 HIGH motif; other site 1110693006447 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1110693006448 active site 1110693006449 KMSKS motif; other site 1110693006450 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1110693006451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693006452 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1110693006453 putative dimerization interface [polypeptide binding]; other site 1110693006454 putative substrate binding pocket [chemical binding]; other site 1110693006455 nucleoside transporter; Region: 2A0110; TIGR00889 1110693006456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693006457 putative substrate translocation pore; other site 1110693006458 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1110693006459 hypothetical protein; Provisional; Region: PRK11528 1110693006460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1110693006461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693006462 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1110693006463 putative dimerization interface [polypeptide binding]; other site 1110693006464 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1110693006465 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1110693006466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1110693006467 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1110693006468 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1110693006469 nucleotide binding pocket [chemical binding]; other site 1110693006470 K-X-D-G motif; other site 1110693006471 catalytic site [active] 1110693006472 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1110693006473 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1110693006474 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1110693006475 Dimer interface [polypeptide binding]; other site 1110693006476 BRCT sequence motif; other site 1110693006477 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1110693006478 cell division protein ZipA; Provisional; Region: PRK03427 1110693006479 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1110693006480 FtsZ protein binding site [polypeptide binding]; other site 1110693006481 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1110693006482 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1110693006483 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1110693006484 dimer interface [polypeptide binding]; other site 1110693006485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693006486 catalytic residue [active] 1110693006487 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1110693006488 dimerization domain swap beta strand [polypeptide binding]; other site 1110693006489 regulatory protein interface [polypeptide binding]; other site 1110693006490 active site 1110693006491 regulatory phosphorylation site [posttranslational modification]; other site 1110693006492 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1110693006493 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1110693006494 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1110693006495 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1110693006496 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1110693006497 HPr interaction site; other site 1110693006498 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1110693006499 active site 1110693006500 phosphorylation site [posttranslational modification] 1110693006501 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1110693006502 dimer interface [polypeptide binding]; other site 1110693006503 pyridoxamine kinase; Validated; Region: PRK05756 1110693006504 pyridoxal binding site [chemical binding]; other site 1110693006505 ATP binding site [chemical binding]; other site 1110693006506 hypothetical protein; Provisional; Region: PRK10318 1110693006507 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1110693006508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 1110693006509 cysteine synthase B; Region: cysM; TIGR01138 1110693006510 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1110693006511 dimer interface [polypeptide binding]; other site 1110693006512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693006513 catalytic residue [active] 1110693006514 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1110693006515 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1110693006516 Walker A/P-loop; other site 1110693006517 ATP binding site [chemical binding]; other site 1110693006518 Q-loop/lid; other site 1110693006519 ABC transporter signature motif; other site 1110693006520 Walker B; other site 1110693006521 D-loop; other site 1110693006522 H-loop/switch region; other site 1110693006523 TOBE-like domain; Region: TOBE_3; pfam12857 1110693006524 sulfate transport protein; Provisional; Region: cysT; CHL00187 1110693006525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693006526 dimer interface [polypeptide binding]; other site 1110693006527 conserved gate region; other site 1110693006528 putative PBP binding loops; other site 1110693006529 ABC-ATPase subunit interface; other site 1110693006530 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1110693006531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693006532 dimer interface [polypeptide binding]; other site 1110693006533 conserved gate region; other site 1110693006534 putative PBP binding loops; other site 1110693006535 ABC-ATPase subunit interface; other site 1110693006536 thiosulfate transporter subunit; Provisional; Region: PRK10852 1110693006537 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1110693006538 short chain dehydrogenase; Provisional; Region: PRK08226 1110693006539 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1110693006540 NAD binding site [chemical binding]; other site 1110693006541 homotetramer interface [polypeptide binding]; other site 1110693006542 homodimer interface [polypeptide binding]; other site 1110693006543 active site 1110693006544 transcriptional regulator MurR; Provisional; Region: PRK15482 1110693006545 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1110693006546 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1110693006547 putative active site [active] 1110693006548 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1110693006549 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1110693006550 putative active site [active] 1110693006551 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1110693006552 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1110693006553 active site turn [active] 1110693006554 phosphorylation site [posttranslational modification] 1110693006555 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1110693006556 putative periplasmic esterase; Provisional; Region: PRK03642 1110693006557 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1110693006558 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1110693006559 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1110693006560 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1110693006561 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1110693006562 putative acetyltransferase; Provisional; Region: PRK03624 1110693006563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1110693006564 Coenzyme A binding pocket [chemical binding]; other site 1110693006565 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1110693006566 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1110693006567 active site 1110693006568 metal binding site [ion binding]; metal-binding site 1110693006569 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1110693006570 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1110693006571 transcriptional regulator EutR; Provisional; Region: PRK10130 1110693006572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693006573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693006574 carboxysome structural protein EutK; Provisional; Region: PRK15466 1110693006575 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1110693006576 Hexamer interface [polypeptide binding]; other site 1110693006577 Hexagonal pore residue; other site 1110693006578 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1110693006579 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1110693006580 putative hexamer interface [polypeptide binding]; other site 1110693006581 putative hexagonal pore; other site 1110693006582 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1110693006583 putative hexamer interface [polypeptide binding]; other site 1110693006584 putative hexagonal pore; other site 1110693006585 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1110693006586 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 1110693006587 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1110693006588 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1110693006589 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1110693006590 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 1110693006591 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 1110693006592 active site 1110693006593 metal binding site [ion binding]; metal-binding site 1110693006594 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 1110693006595 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1110693006596 nucleotide binding site [chemical binding]; other site 1110693006597 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1110693006598 putative catalytic cysteine [active] 1110693006599 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1110693006600 Hexamer/Pentamer interface [polypeptide binding]; other site 1110693006601 central pore; other site 1110693006602 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1110693006603 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1110693006604 Hexamer interface [polypeptide binding]; other site 1110693006605 Putative hexagonal pore residue; other site 1110693006606 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1110693006607 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 1110693006608 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1110693006609 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 1110693006610 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1110693006611 G1 box; other site 1110693006612 GTP/Mg2+ binding site [chemical binding]; other site 1110693006613 G2 box; other site 1110693006614 Switch I region; other site 1110693006615 G3 box; other site 1110693006616 Switch II region; other site 1110693006617 G4 box; other site 1110693006618 G5 box; other site 1110693006619 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1110693006620 putative hexamer interface [polypeptide binding]; other site 1110693006621 putative hexagonal pore; other site 1110693006622 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1110693006623 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1110693006624 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1110693006625 putative NAD(P) binding site [chemical binding]; other site 1110693006626 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1110693006627 transaldolase-like protein; Provisional; Region: PTZ00411 1110693006628 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1110693006629 active site 1110693006630 dimer interface [polypeptide binding]; other site 1110693006631 catalytic residue [active] 1110693006632 transketolase; Reviewed; Region: PRK12753 1110693006633 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1110693006634 TPP-binding site [chemical binding]; other site 1110693006635 dimer interface [polypeptide binding]; other site 1110693006636 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1110693006637 PYR/PP interface [polypeptide binding]; other site 1110693006638 dimer interface [polypeptide binding]; other site 1110693006639 TPP binding site [chemical binding]; other site 1110693006640 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1110693006641 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1110693006642 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1110693006643 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1110693006644 dimer interface [polypeptide binding]; other site 1110693006645 ADP-ribose binding site [chemical binding]; other site 1110693006646 active site 1110693006647 nudix motif; other site 1110693006648 metal binding site [ion binding]; metal-binding site 1110693006649 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1110693006650 4Fe-4S binding domain; Region: Fer4; pfam00037 1110693006651 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1110693006652 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693006653 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1110693006654 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1110693006655 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1110693006656 dimerization interface [polypeptide binding]; other site 1110693006657 Histidine kinase; Region: HisKA_3; pfam07730 1110693006658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693006659 ATP binding site [chemical binding]; other site 1110693006660 Mg2+ binding site [ion binding]; other site 1110693006661 G-X-G motif; other site 1110693006662 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1110693006663 Protein export membrane protein; Region: SecD_SecF; cl14618 1110693006664 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1110693006665 ArsC family; Region: ArsC; pfam03960 1110693006666 putative catalytic residues [active] 1110693006667 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1110693006668 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1110693006669 metal binding site [ion binding]; metal-binding site 1110693006670 dimer interface [polypeptide binding]; other site 1110693006671 hypothetical protein; Provisional; Region: PRK13664 1110693006672 putative hydrolase; Provisional; Region: PRK11460 1110693006673 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1110693006674 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1110693006675 Helicase; Region: Helicase_RecD; pfam05127 1110693006676 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1110693006677 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1110693006678 Predicted metalloprotease [General function prediction only]; Region: COG2321 1110693006679 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1110693006680 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1110693006681 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1110693006682 ATP binding site [chemical binding]; other site 1110693006683 active site 1110693006684 substrate binding site [chemical binding]; other site 1110693006685 lipoprotein; Provisional; Region: PRK11679 1110693006686 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1110693006687 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1110693006688 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1110693006689 dimer interface [polypeptide binding]; other site 1110693006690 active site 1110693006691 catalytic residue [active] 1110693006692 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1110693006693 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1110693006694 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1110693006695 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1110693006696 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1110693006697 catalytic triad [active] 1110693006698 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1110693006699 4Fe-4S binding domain; Region: Fer4; pfam00037 1110693006700 hydrogenase 4 subunit B; Validated; Region: PRK06521 1110693006701 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1110693006702 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1110693006703 NADH dehydrogenase; Region: NADHdh; cl00469 1110693006704 hydrogenase 4 subunit D; Validated; Region: PRK06525 1110693006705 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1110693006706 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 1110693006707 hydrogenase 4 subunit F; Validated; Region: PRK06458 1110693006708 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1110693006709 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1110693006710 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1110693006711 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1110693006712 hydrogenase 4 subunit H; Validated; Region: PRK08222 1110693006713 4Fe-4S binding domain; Region: Fer4; pfam00037 1110693006714 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1110693006715 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1110693006716 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1110693006717 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1110693006718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693006719 Walker A motif; other site 1110693006720 ATP binding site [chemical binding]; other site 1110693006721 Walker B motif; other site 1110693006722 arginine finger; other site 1110693006723 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1110693006724 putative formate transporter; Provisional; Region: focB; PRK09713 1110693006725 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1110693006726 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1110693006727 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1110693006728 Peptidase family M48; Region: Peptidase_M48; cl12018 1110693006729 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1110693006730 ArsC family; Region: ArsC; pfam03960 1110693006731 catalytic residues [active] 1110693006732 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1110693006733 DNA replication initiation factor; Provisional; Region: PRK08084 1110693006734 uracil transporter; Provisional; Region: PRK10720 1110693006735 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1110693006736 active site 1110693006737 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1110693006738 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1110693006739 dimerization interface [polypeptide binding]; other site 1110693006740 putative ATP binding site [chemical binding]; other site 1110693006741 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1110693006742 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1110693006743 active site 1110693006744 substrate binding site [chemical binding]; other site 1110693006745 cosubstrate binding site; other site 1110693006746 catalytic site [active] 1110693006747 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1110693006748 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1110693006749 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1110693006750 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 1110693006751 domain interface [polypeptide binding]; other site 1110693006752 active site 1110693006753 catalytic site [active] 1110693006754 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1110693006755 putative active site [active] 1110693006756 catalytic site [active] 1110693006757 exopolyphosphatase; Provisional; Region: PRK10854 1110693006758 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1110693006759 MASE1; Region: MASE1; pfam05231 1110693006760 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1110693006761 diguanylate cyclase; Region: GGDEF; smart00267 1110693006762 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1110693006763 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1110693006764 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1110693006765 GMP synthase; Reviewed; Region: guaA; PRK00074 1110693006766 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1110693006767 AMP/PPi binding site [chemical binding]; other site 1110693006768 candidate oxyanion hole; other site 1110693006769 catalytic triad [active] 1110693006770 potential glutamine specificity residues [chemical binding]; other site 1110693006771 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1110693006772 ATP Binding subdomain [chemical binding]; other site 1110693006773 Ligand Binding sites [chemical binding]; other site 1110693006774 Dimerization subdomain; other site 1110693006775 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1110693006776 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1110693006777 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1110693006778 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1110693006779 active site 1110693006780 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1110693006781 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1110693006782 generic binding surface II; other site 1110693006783 generic binding surface I; other site 1110693006784 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1110693006785 GTP-binding protein Der; Reviewed; Region: PRK00093 1110693006786 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1110693006787 G1 box; other site 1110693006788 GTP/Mg2+ binding site [chemical binding]; other site 1110693006789 Switch I region; other site 1110693006790 G2 box; other site 1110693006791 Switch II region; other site 1110693006792 G3 box; other site 1110693006793 G4 box; other site 1110693006794 G5 box; other site 1110693006795 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1110693006796 G1 box; other site 1110693006797 GTP/Mg2+ binding site [chemical binding]; other site 1110693006798 Switch I region; other site 1110693006799 G2 box; other site 1110693006800 G3 box; other site 1110693006801 Switch II region; other site 1110693006802 G4 box; other site 1110693006803 G5 box; other site 1110693006804 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1110693006805 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 1110693006806 Trp docking motif [polypeptide binding]; other site 1110693006807 active site 1110693006808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1110693006809 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1110693006810 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1110693006811 dimer interface [polypeptide binding]; other site 1110693006812 motif 1; other site 1110693006813 active site 1110693006814 motif 2; other site 1110693006815 motif 3; other site 1110693006816 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1110693006817 anticodon binding site; other site 1110693006818 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1110693006819 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1110693006820 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1110693006821 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1110693006822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1110693006823 non-specific DNA binding site [nucleotide binding]; other site 1110693006824 salt bridge; other site 1110693006825 sequence-specific DNA binding site [nucleotide binding]; other site 1110693006826 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1110693006827 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1110693006828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693006829 FeS/SAM binding site; other site 1110693006830 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1110693006831 active site 1110693006832 multimer interface [polypeptide binding]; other site 1110693006833 penicillin-binding protein 1C; Provisional; Region: PRK11240 1110693006834 Transglycosylase; Region: Transgly; pfam00912 1110693006835 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1110693006836 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1110693006837 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1110693006838 MG2 domain; Region: A2M_N; pfam01835 1110693006839 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1110693006840 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1110693006841 surface patch; other site 1110693006842 thioester region; other site 1110693006843 specificity defining residues; other site 1110693006844 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1110693006845 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1110693006846 active site residue [active] 1110693006847 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1110693006848 active site residue [active] 1110693006849 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1110693006850 aminopeptidase B; Provisional; Region: PRK05015 1110693006851 Peptidase; Region: DUF3663; pfam12404 1110693006852 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1110693006853 interface (dimer of trimers) [polypeptide binding]; other site 1110693006854 Substrate-binding/catalytic site; other site 1110693006855 Zn-binding sites [ion binding]; other site 1110693006856 hypothetical protein; Provisional; Region: PRK10721 1110693006857 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1110693006858 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1110693006859 catalytic loop [active] 1110693006860 iron binding site [ion binding]; other site 1110693006861 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1110693006862 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1110693006863 nucleotide binding site [chemical binding]; other site 1110693006864 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1110693006865 SBD interface [polypeptide binding]; other site 1110693006866 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1110693006867 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1110693006868 HSP70 interaction site [polypeptide binding]; other site 1110693006869 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1110693006870 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1110693006871 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1110693006872 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1110693006873 trimerization site [polypeptide binding]; other site 1110693006874 active site 1110693006875 cysteine desulfurase; Provisional; Region: PRK14012 1110693006876 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1110693006877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1110693006878 catalytic residue [active] 1110693006879 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1110693006880 Rrf2 family protein; Region: rrf2_super; TIGR00738 1110693006881 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1110693006882 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1110693006883 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1110693006884 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1110693006885 active site 1110693006886 dimerization interface [polypeptide binding]; other site 1110693006887 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1110693006888 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1110693006889 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1110693006890 PRD domain; Region: PRD; pfam00874 1110693006891 PRD domain; Region: PRD; pfam00874 1110693006892 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1110693006893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693006894 putative substrate translocation pore; other site 1110693006895 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1110693006896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693006897 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1110693006898 dimerization interface [polypeptide binding]; other site 1110693006899 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1110693006900 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1110693006901 iron-sulfur cluster [ion binding]; other site 1110693006902 [2Fe-2S] cluster binding site [ion binding]; other site 1110693006903 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1110693006904 beta subunit interface [polypeptide binding]; other site 1110693006905 alpha subunit interface [polypeptide binding]; other site 1110693006906 active site 1110693006907 substrate binding site [chemical binding]; other site 1110693006908 Fe binding site [ion binding]; other site 1110693006909 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1110693006910 inter-subunit interface; other site 1110693006911 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1110693006912 [2Fe-2S] cluster binding site [ion binding]; other site 1110693006913 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1110693006914 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 1110693006915 NAD binding site [chemical binding]; other site 1110693006916 active site 1110693006917 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1110693006918 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693006919 Predicted membrane protein [Function unknown]; Region: COG2259 1110693006920 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1110693006921 active site 1110693006922 catalytic residues [active] 1110693006923 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1110693006924 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 1110693006925 putative NAD(P) binding site [chemical binding]; other site 1110693006926 catalytic Zn binding site [ion binding]; other site 1110693006927 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1110693006928 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1110693006929 TM-ABC transporter signature motif; other site 1110693006930 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1110693006931 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1110693006932 Walker A/P-loop; other site 1110693006933 ATP binding site [chemical binding]; other site 1110693006934 Q-loop/lid; other site 1110693006935 ABC transporter signature motif; other site 1110693006936 Walker B; other site 1110693006937 D-loop; other site 1110693006938 H-loop/switch region; other site 1110693006939 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1110693006940 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1110693006941 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1110693006942 ligand binding site [chemical binding]; other site 1110693006943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1110693006944 TPR motif; other site 1110693006945 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1110693006946 binding surface 1110693006947 TPR repeat; Region: TPR_11; pfam13414 1110693006948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1110693006949 TPR motif; other site 1110693006950 binding surface 1110693006951 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1110693006952 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1110693006953 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1110693006954 nucleotide binding site [chemical binding]; other site 1110693006955 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1110693006956 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1110693006957 dimer interface [polypeptide binding]; other site 1110693006958 active site 1110693006959 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1110693006960 folate binding site [chemical binding]; other site 1110693006961 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1110693006962 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1110693006963 heme-binding site [chemical binding]; other site 1110693006964 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1110693006965 FAD binding pocket [chemical binding]; other site 1110693006966 FAD binding motif [chemical binding]; other site 1110693006967 phosphate binding motif [ion binding]; other site 1110693006968 beta-alpha-beta structure motif; other site 1110693006969 NAD binding pocket [chemical binding]; other site 1110693006970 Heme binding pocket [chemical binding]; other site 1110693006971 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1110693006972 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1110693006973 response regulator GlrR; Provisional; Region: PRK15115 1110693006974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693006975 active site 1110693006976 phosphorylation site [posttranslational modification] 1110693006977 intermolecular recognition site; other site 1110693006978 dimerization interface [polypeptide binding]; other site 1110693006979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693006980 Walker A motif; other site 1110693006981 ATP binding site [chemical binding]; other site 1110693006982 Walker B motif; other site 1110693006983 arginine finger; other site 1110693006984 hypothetical protein; Provisional; Region: PRK10722 1110693006985 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1110693006986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693006987 dimer interface [polypeptide binding]; other site 1110693006988 phosphorylation site [posttranslational modification] 1110693006989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693006990 ATP binding site [chemical binding]; other site 1110693006991 Mg2+ binding site [ion binding]; other site 1110693006992 G-X-G motif; other site 1110693006993 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1110693006994 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1110693006995 dimerization interface [polypeptide binding]; other site 1110693006996 ATP binding site [chemical binding]; other site 1110693006997 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1110693006998 dimerization interface [polypeptide binding]; other site 1110693006999 ATP binding site [chemical binding]; other site 1110693007000 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1110693007001 putative active site [active] 1110693007002 catalytic triad [active] 1110693007003 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1110693007004 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693007005 substrate binding pocket [chemical binding]; other site 1110693007006 membrane-bound complex binding site; other site 1110693007007 hinge residues; other site 1110693007008 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1110693007009 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1110693007010 catalytic residue [active] 1110693007011 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1110693007012 nucleoside/Zn binding site; other site 1110693007013 dimer interface [polypeptide binding]; other site 1110693007014 catalytic motif [active] 1110693007015 hypothetical protein; Provisional; Region: PRK11590 1110693007016 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1110693007017 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1110693007018 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1110693007019 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1110693007020 putative active site [active] 1110693007021 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1110693007022 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 1110693007023 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1110693007024 active site 1110693007025 hydrophilic channel; other site 1110693007026 dimerization interface [polypeptide binding]; other site 1110693007027 catalytic residues [active] 1110693007028 active site lid [active] 1110693007029 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1110693007030 Recombination protein O N terminal; Region: RecO_N; pfam11967 1110693007031 Recombination protein O C terminal; Region: RecO_C; pfam02565 1110693007032 GTPase Era; Reviewed; Region: era; PRK00089 1110693007033 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1110693007034 G1 box; other site 1110693007035 GTP/Mg2+ binding site [chemical binding]; other site 1110693007036 Switch I region; other site 1110693007037 G2 box; other site 1110693007038 Switch II region; other site 1110693007039 G3 box; other site 1110693007040 G4 box; other site 1110693007041 G5 box; other site 1110693007042 KH domain; Region: KH_2; pfam07650 1110693007043 ribonuclease III; Reviewed; Region: rnc; PRK00102 1110693007044 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1110693007045 dimerization interface [polypeptide binding]; other site 1110693007046 active site 1110693007047 metal binding site [ion binding]; metal-binding site 1110693007048 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1110693007049 dsRNA binding site [nucleotide binding]; other site 1110693007050 signal peptidase I; Provisional; Region: PRK10861 1110693007051 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1110693007052 Catalytic site [active] 1110693007053 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1110693007054 GTP-binding protein LepA; Provisional; Region: PRK05433 1110693007055 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1110693007056 G1 box; other site 1110693007057 putative GEF interaction site [polypeptide binding]; other site 1110693007058 GTP/Mg2+ binding site [chemical binding]; other site 1110693007059 Switch I region; other site 1110693007060 G2 box; other site 1110693007061 G3 box; other site 1110693007062 Switch II region; other site 1110693007063 G4 box; other site 1110693007064 G5 box; other site 1110693007065 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1110693007066 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1110693007067 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1110693007068 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1110693007069 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1110693007070 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1110693007071 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1110693007072 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1110693007073 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1110693007074 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1110693007075 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1110693007076 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1110693007077 DNA binding residues [nucleotide binding] 1110693007078 L-aspartate oxidase; Provisional; Region: PRK09077 1110693007079 L-aspartate oxidase; Provisional; Region: PRK06175 1110693007080 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1110693007081 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1110693007082 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1110693007083 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1110693007084 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1110693007085 ATP binding site [chemical binding]; other site 1110693007086 Mg++ binding site [ion binding]; other site 1110693007087 motif III; other site 1110693007088 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1110693007089 nucleotide binding region [chemical binding]; other site 1110693007090 ATP-binding site [chemical binding]; other site 1110693007091 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1110693007092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693007093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1110693007094 dimerization interface [polypeptide binding]; other site 1110693007095 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 1110693007096 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1110693007097 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1110693007098 ligand binding site [chemical binding]; other site 1110693007099 active site 1110693007100 UGI interface [polypeptide binding]; other site 1110693007101 catalytic site [active] 1110693007102 putative methyltransferase; Provisional; Region: PRK10864 1110693007103 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1110693007104 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1110693007105 thioredoxin 2; Provisional; Region: PRK10996 1110693007106 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1110693007107 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1110693007108 catalytic residues [active] 1110693007109 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1110693007110 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1110693007111 CoA binding domain; Region: CoA_binding_2; pfam13380 1110693007112 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1110693007113 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1110693007114 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1110693007115 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1110693007116 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1110693007117 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1110693007118 domain interface [polypeptide binding]; other site 1110693007119 putative active site [active] 1110693007120 catalytic site [active] 1110693007121 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1110693007122 domain interface [polypeptide binding]; other site 1110693007123 putative active site [active] 1110693007124 catalytic site [active] 1110693007125 lipoprotein; Provisional; Region: PRK10759 1110693007126 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1110693007127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693007128 putative substrate translocation pore; other site 1110693007129 protein disaggregation chaperone; Provisional; Region: PRK10865 1110693007130 Clp amino terminal domain; Region: Clp_N; pfam02861 1110693007131 Clp amino terminal domain; Region: Clp_N; pfam02861 1110693007132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693007133 Walker A motif; other site 1110693007134 ATP binding site [chemical binding]; other site 1110693007135 Walker B motif; other site 1110693007136 arginine finger; other site 1110693007137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693007138 Walker A motif; other site 1110693007139 ATP binding site [chemical binding]; other site 1110693007140 Walker B motif; other site 1110693007141 arginine finger; other site 1110693007142 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1110693007143 hypothetical protein; Provisional; Region: PRK10723 1110693007144 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1110693007145 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1110693007146 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1110693007147 RNA binding surface [nucleotide binding]; other site 1110693007148 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1110693007149 active site 1110693007150 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1110693007151 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1110693007152 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1110693007153 30S subunit binding site; other site 1110693007154 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1110693007155 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1110693007156 Prephenate dehydratase; Region: PDT; pfam00800 1110693007157 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1110693007158 putative L-Phe binding site [chemical binding]; other site 1110693007159 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1110693007160 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 1110693007161 prephenate dehydrogenase; Validated; Region: PRK08507 1110693007162 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1110693007163 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1110693007164 lipoprotein; Provisional; Region: PRK11443 1110693007165 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 1110693007166 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1110693007167 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1110693007168 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693007169 metal binding site [ion binding]; metal-binding site 1110693007170 active site 1110693007171 I-site; other site 1110693007172 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1110693007173 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1110693007174 ligand binding site [chemical binding]; other site 1110693007175 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1110693007176 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1110693007177 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1110693007178 RimM N-terminal domain; Region: RimM; pfam01782 1110693007179 PRC-barrel domain; Region: PRC; pfam05239 1110693007180 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1110693007181 signal recognition particle protein; Provisional; Region: PRK10867 1110693007182 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1110693007183 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1110693007184 P loop; other site 1110693007185 GTP binding site [chemical binding]; other site 1110693007186 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1110693007187 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1110693007188 hypothetical protein; Provisional; Region: PRK11573 1110693007189 Domain of unknown function DUF21; Region: DUF21; pfam01595 1110693007190 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1110693007191 Transporter associated domain; Region: CorC_HlyC; smart01091 1110693007192 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1110693007193 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1110693007194 dimer interface [polypeptide binding]; other site 1110693007195 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1110693007196 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1110693007197 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1110693007198 recombination and repair protein; Provisional; Region: PRK10869 1110693007199 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1110693007200 Walker A/P-loop; other site 1110693007201 ATP binding site [chemical binding]; other site 1110693007202 Q-loop/lid; other site 1110693007203 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1110693007204 Q-loop/lid; other site 1110693007205 ABC transporter signature motif; other site 1110693007206 Walker B; other site 1110693007207 D-loop; other site 1110693007208 H-loop/switch region; other site 1110693007209 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1110693007210 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1110693007211 hypothetical protein; Validated; Region: PRK01777 1110693007212 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1110693007213 putative coenzyme Q binding site [chemical binding]; other site 1110693007214 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1110693007215 SmpB-tmRNA interface; other site 1110693007216 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1110693007217 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1110693007218 tetramerization interface [polypeptide binding]; other site 1110693007219 NAD(P) binding site [chemical binding]; other site 1110693007220 catalytic residues [active] 1110693007221 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1110693007222 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1110693007223 inhibitor-cofactor binding pocket; inhibition site 1110693007224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693007225 catalytic residue [active] 1110693007226 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 1110693007227 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1110693007228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693007229 DNA-binding site [nucleotide binding]; DNA binding site 1110693007230 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1110693007231 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1110693007232 bacterial OsmY and nodulation domain; Region: BON; smart00749 1110693007233 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1110693007234 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1110693007235 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1110693007236 dimerization interface [polypeptide binding]; other site 1110693007237 putative DNA binding site [nucleotide binding]; other site 1110693007238 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1110693007239 putative Zn2+ binding site [ion binding]; other site 1110693007240 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 1110693007241 active site residue [active] 1110693007242 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1110693007243 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1110693007244 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1110693007245 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1110693007246 hypothetical protein; Provisional; Region: PRK10556 1110693007247 hypothetical protein; Provisional; Region: PRK10132 1110693007248 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1110693007249 catalytic residues [active] 1110693007250 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1110693007251 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1110693007252 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1110693007253 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1110693007254 active site 1110693007255 dimer interface [polypeptide binding]; other site 1110693007256 catalytic residues [active] 1110693007257 effector binding site; other site 1110693007258 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1110693007259 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1110693007260 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1110693007261 dimer interface [polypeptide binding]; other site 1110693007262 putative radical transfer pathway; other site 1110693007263 diiron center [ion binding]; other site 1110693007264 tyrosyl radical; other site 1110693007265 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1110693007266 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1110693007267 Walker A/P-loop; other site 1110693007268 ATP binding site [chemical binding]; other site 1110693007269 Q-loop/lid; other site 1110693007270 ABC transporter signature motif; other site 1110693007271 Walker B; other site 1110693007272 D-loop; other site 1110693007273 H-loop/switch region; other site 1110693007274 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1110693007275 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1110693007276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693007277 dimer interface [polypeptide binding]; other site 1110693007278 conserved gate region; other site 1110693007279 putative PBP binding loops; other site 1110693007280 ABC-ATPase subunit interface; other site 1110693007281 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1110693007282 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1110693007283 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1110693007284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1110693007285 predicted transporter (pseudogene) 1110693007286 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1110693007287 putative L-valine exporter; Provisional; Region: PRK10408 1110693007288 transcriptional repressor MprA; Provisional; Region: PRK10870 1110693007289 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1110693007290 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1110693007291 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693007292 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693007293 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1110693007294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693007295 putative substrate translocation pore; other site 1110693007296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693007297 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1110693007298 glutamate--cysteine ligase; Provisional; Region: PRK02107 1110693007299 Predicted membrane protein [Function unknown]; Region: COG1238 1110693007300 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1110693007301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693007302 motif II; other site 1110693007303 carbon storage regulator; Provisional; Region: PRK01712 1110693007304 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1110693007305 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1110693007306 motif 1; other site 1110693007307 active site 1110693007308 motif 2; other site 1110693007309 motif 3; other site 1110693007310 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1110693007311 DHHA1 domain; Region: DHHA1; pfam02272 1110693007312 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1110693007313 recombinase A; Provisional; Region: recA; PRK09354 1110693007314 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1110693007315 hexamer interface [polypeptide binding]; other site 1110693007316 Walker A motif; other site 1110693007317 ATP binding site [chemical binding]; other site 1110693007318 Walker B motif; other site 1110693007319 hypothetical protein; Validated; Region: PRK03661 1110693007320 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1110693007321 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1110693007322 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1110693007323 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 1110693007324 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1110693007325 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1110693007326 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1110693007327 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1110693007328 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1110693007329 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1110693007330 putative NAD(P) binding site [chemical binding]; other site 1110693007331 active site 1110693007332 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1110693007333 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1110693007334 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1110693007335 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1110693007336 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1110693007337 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1110693007338 putative active site [active] 1110693007339 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1110693007340 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1110693007341 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1110693007342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693007343 Walker A motif; other site 1110693007344 ATP binding site [chemical binding]; other site 1110693007345 Walker B motif; other site 1110693007346 arginine finger; other site 1110693007347 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1110693007348 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1110693007349 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1110693007350 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1110693007351 iron binding site [ion binding]; other site 1110693007352 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1110693007353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693007354 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1110693007355 Acylphosphatase; Region: Acylphosphatase; pfam00708 1110693007356 HypF finger; Region: zf-HYPF; pfam07503 1110693007357 HypF finger; Region: zf-HYPF; pfam07503 1110693007358 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1110693007359 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1110693007360 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1110693007361 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1110693007362 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693007363 DNA binding site [nucleotide binding] 1110693007364 domain linker motif; other site 1110693007365 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1110693007366 dimerization interface (closed form) [polypeptide binding]; other site 1110693007367 ligand binding site [chemical binding]; other site 1110693007368 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1110693007369 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1110693007370 active site turn [active] 1110693007371 phosphorylation site [posttranslational modification] 1110693007372 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1110693007373 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 1110693007374 beta-galactosidase; Region: BGL; TIGR03356 1110693007375 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1110693007376 nickel binding site [ion binding]; other site 1110693007377 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1110693007378 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1110693007379 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1110693007380 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1110693007381 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1110693007382 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1110693007383 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1110693007384 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1110693007385 NADH dehydrogenase; Region: NADHdh; cl00469 1110693007386 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1110693007387 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1110693007388 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1110693007389 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1110693007390 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1110693007391 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1110693007392 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1110693007393 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1110693007394 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1110693007395 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1110693007396 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1110693007397 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1110693007398 dimerization interface [polypeptide binding]; other site 1110693007399 ATP binding site [chemical binding]; other site 1110693007400 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1110693007401 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1110693007402 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1110693007403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693007404 Walker A motif; other site 1110693007405 ATP binding site [chemical binding]; other site 1110693007406 Walker B motif; other site 1110693007407 arginine finger; other site 1110693007408 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1110693007409 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1110693007410 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1110693007411 MutS domain I; Region: MutS_I; pfam01624 1110693007412 MutS domain II; Region: MutS_II; pfam05188 1110693007413 MutS domain III; Region: MutS_III; pfam05192 1110693007414 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1110693007415 Walker A/P-loop; other site 1110693007416 ATP binding site [chemical binding]; other site 1110693007417 Q-loop/lid; other site 1110693007418 ABC transporter signature motif; other site 1110693007419 Walker B; other site 1110693007420 D-loop; other site 1110693007421 H-loop/switch region; other site 1110693007422 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1110693007423 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1110693007424 active site 1110693007425 metal binding site [ion binding]; metal-binding site 1110693007426 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1110693007427 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1110693007428 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1110693007429 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1110693007430 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1110693007431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1110693007432 putative aldolase; Validated; Region: PRK08130 1110693007433 active site 1110693007434 intersubunit interface [polypeptide binding]; other site 1110693007435 Zn2+ binding site [ion binding]; other site 1110693007436 hypothetical protein; Provisional; Region: PRK09989 1110693007437 putative transporter; Provisional; Region: PRK09821 1110693007438 GntP family permease; Region: GntP_permease; pfam02447 1110693007439 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1110693007440 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1110693007441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1110693007442 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1110693007443 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1110693007444 DNA binding residues [nucleotide binding] 1110693007445 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1110693007446 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1110693007447 Peptidase family M23; Region: Peptidase_M23; pfam01551 1110693007448 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1110693007449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693007450 S-adenosylmethionine binding site [chemical binding]; other site 1110693007451 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1110693007452 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1110693007453 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1110693007454 Permutation of conserved domain; other site 1110693007455 active site 1110693007456 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1110693007457 homotrimer interaction site [polypeptide binding]; other site 1110693007458 zinc binding site [ion binding]; other site 1110693007459 CDP-binding sites; other site 1110693007460 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1110693007461 substrate binding site; other site 1110693007462 dimer interface; other site 1110693007463 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1110693007464 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1110693007465 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1110693007466 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1110693007467 ligand-binding site [chemical binding]; other site 1110693007468 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1110693007469 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1110693007470 CysD dimerization site [polypeptide binding]; other site 1110693007471 G1 box; other site 1110693007472 putative GEF interaction site [polypeptide binding]; other site 1110693007473 GTP/Mg2+ binding site [chemical binding]; other site 1110693007474 Switch I region; other site 1110693007475 G2 box; other site 1110693007476 G3 box; other site 1110693007477 Switch II region; other site 1110693007478 G4 box; other site 1110693007479 G5 box; other site 1110693007480 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1110693007481 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1110693007482 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1110693007483 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1110693007484 Active Sites [active] 1110693007485 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1110693007486 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1110693007487 metal binding site [ion binding]; metal-binding site 1110693007488 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1110693007489 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1110693007490 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 1110693007491 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1110693007492 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1110693007493 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 1110693007494 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 1110693007495 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 1110693007496 helicase Cas3; Provisional; Region: PRK09694 1110693007497 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1110693007498 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 1110693007499 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1110693007500 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1110693007501 Active Sites [active] 1110693007502 sulfite reductase subunit beta; Provisional; Region: PRK13504 1110693007503 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1110693007504 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1110693007505 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1110693007506 Flavodoxin; Region: Flavodoxin_1; pfam00258 1110693007507 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1110693007508 FAD binding pocket [chemical binding]; other site 1110693007509 FAD binding motif [chemical binding]; other site 1110693007510 catalytic residues [active] 1110693007511 NAD binding pocket [chemical binding]; other site 1110693007512 phosphate binding motif [ion binding]; other site 1110693007513 beta-alpha-beta structure motif; other site 1110693007514 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 1110693007515 homohexamer interface [polypeptide binding]; other site 1110693007516 putative substrate stabilizing pore; other site 1110693007517 pterin binding site; other site 1110693007518 putative oxidoreductase FixC; Provisional; Region: PRK10157 1110693007519 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1110693007520 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1110693007521 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1110693007522 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1110693007523 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1110693007524 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1110693007525 Ligand binding site [chemical binding]; other site 1110693007526 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1110693007527 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1110693007528 benzoate transport; Region: 2A0115; TIGR00895 1110693007529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693007530 putative substrate translocation pore; other site 1110693007531 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1110693007532 FAD binding domain; Region: FAD_binding_4; pfam01565 1110693007533 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1110693007534 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1110693007535 NADP binding site [chemical binding]; other site 1110693007536 homodimer interface [polypeptide binding]; other site 1110693007537 active site 1110693007538 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1110693007539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693007540 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1110693007541 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1110693007542 nucleotide binding site [chemical binding]; other site 1110693007543 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1110693007544 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1110693007545 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1110693007546 Repair protein; Region: Repair_PSII; pfam04536 1110693007547 enolase; Provisional; Region: eno; PRK00077 1110693007548 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1110693007549 dimer interface [polypeptide binding]; other site 1110693007550 metal binding site [ion binding]; metal-binding site 1110693007551 substrate binding pocket [chemical binding]; other site 1110693007552 CTP synthetase; Validated; Region: pyrG; PRK05380 1110693007553 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1110693007554 Catalytic site [active] 1110693007555 active site 1110693007556 UTP binding site [chemical binding]; other site 1110693007557 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1110693007558 active site 1110693007559 putative oxyanion hole; other site 1110693007560 catalytic triad [active] 1110693007561 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1110693007562 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1110693007563 homodimer interface [polypeptide binding]; other site 1110693007564 metal binding site [ion binding]; metal-binding site 1110693007565 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1110693007566 homodimer interface [polypeptide binding]; other site 1110693007567 active site 1110693007568 putative chemical substrate binding site [chemical binding]; other site 1110693007569 metal binding site [ion binding]; metal-binding site 1110693007570 toxin MazF; Provisional; Region: PRK09907 1110693007571 antitoxin MazE; Provisional; Region: PRK09798 1110693007572 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1110693007573 HD domain; Region: HD_4; pfam13328 1110693007574 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1110693007575 synthetase active site [active] 1110693007576 NTP binding site [chemical binding]; other site 1110693007577 metal binding site [ion binding]; metal-binding site 1110693007578 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1110693007579 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1110693007580 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1110693007581 TRAM domain; Region: TRAM; pfam01938 1110693007582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693007583 S-adenosylmethionine binding site [chemical binding]; other site 1110693007584 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1110693007585 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1110693007586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1110693007587 dimerization interface [polypeptide binding]; other site 1110693007588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693007589 dimer interface [polypeptide binding]; other site 1110693007590 phosphorylation site [posttranslational modification] 1110693007591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693007592 ATP binding site [chemical binding]; other site 1110693007593 Mg2+ binding site [ion binding]; other site 1110693007594 G-X-G motif; other site 1110693007595 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1110693007596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693007597 active site 1110693007598 phosphorylation site [posttranslational modification] 1110693007599 intermolecular recognition site; other site 1110693007600 dimerization interface [polypeptide binding]; other site 1110693007601 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1110693007602 putative binding surface; other site 1110693007603 active site 1110693007604 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1110693007605 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1110693007606 active site 1110693007607 tetramer interface [polypeptide binding]; other site 1110693007608 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1110693007609 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1110693007610 active site 1110693007611 tetramer interface [polypeptide binding]; other site 1110693007612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693007613 D-galactonate transporter; Region: 2A0114; TIGR00893 1110693007614 putative substrate translocation pore; other site 1110693007615 flavodoxin; Provisional; Region: PRK08105 1110693007616 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1110693007617 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1110693007618 probable active site [active] 1110693007619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1110693007620 SecY interacting protein Syd; Provisional; Region: PRK04968 1110693007621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1110693007622 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1110693007623 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1110693007624 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1110693007625 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1110693007626 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1110693007627 serine transporter; Region: stp; TIGR00814 1110693007628 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1110693007629 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1110693007630 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1110693007631 flap endonuclease-like protein; Provisional; Region: PRK09482 1110693007632 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1110693007633 active site 1110693007634 metal binding site 1 [ion binding]; metal-binding site 1110693007635 putative 5' ssDNA interaction site; other site 1110693007636 metal binding site 3; metal-binding site 1110693007637 metal binding site 2 [ion binding]; metal-binding site 1110693007638 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1110693007639 putative DNA binding site [nucleotide binding]; other site 1110693007640 putative metal binding site [ion binding]; other site 1110693007641 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1110693007642 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1110693007643 dimer interface [polypeptide binding]; other site 1110693007644 active site 1110693007645 metal binding site [ion binding]; metal-binding site 1110693007646 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1110693007647 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1110693007648 intersubunit interface [polypeptide binding]; other site 1110693007649 active site 1110693007650 Zn2+ binding site [ion binding]; other site 1110693007651 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1110693007652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693007653 putative substrate translocation pore; other site 1110693007654 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1110693007655 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 1110693007656 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1110693007657 trimer interface [polypeptide binding]; other site 1110693007658 substrate binding site [chemical binding]; other site 1110693007659 Mn binding site [ion binding]; other site 1110693007660 L-fuculokinase; Provisional; Region: PRK10331 1110693007661 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1110693007662 nucleotide binding site [chemical binding]; other site 1110693007663 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 1110693007664 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1110693007665 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1110693007666 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1110693007667 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1110693007668 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1110693007669 hypothetical protein; Provisional; Region: PRK10873 1110693007670 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1110693007671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693007672 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1110693007673 dimerization interface [polypeptide binding]; other site 1110693007674 substrate binding pocket [chemical binding]; other site 1110693007675 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1110693007676 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1110693007677 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1110693007678 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1110693007679 catalytic residue [active] 1110693007680 CsdA-binding activator; Provisional; Region: PRK15019 1110693007681 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1110693007682 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1110693007683 putative ATP binding site [chemical binding]; other site 1110693007684 putative substrate interface [chemical binding]; other site 1110693007685 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1110693007686 MltA specific insert domain; Region: MltA; pfam03562 1110693007687 3D domain; Region: 3D; pfam06725 1110693007688 AMIN domain; Region: AMIN; pfam11741 1110693007689 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1110693007690 active site 1110693007691 metal binding site [ion binding]; metal-binding site 1110693007692 N-acetylglutamate synthase; Validated; Region: PRK05279 1110693007693 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1110693007694 putative feedback inhibition sensing region; other site 1110693007695 putative nucleotide binding site [chemical binding]; other site 1110693007696 putative substrate binding site [chemical binding]; other site 1110693007697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1110693007698 Coenzyme A binding pocket [chemical binding]; other site 1110693007699 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1110693007700 AAA domain; Region: AAA_30; pfam13604 1110693007701 Family description; Region: UvrD_C_2; pfam13538 1110693007702 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1110693007703 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1110693007704 protease3; Provisional; Region: PRK15101 1110693007705 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1110693007706 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1110693007707 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1110693007708 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1110693007709 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1110693007710 hypothetical protein; Provisional; Region: PRK10332 1110693007711 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1110693007712 hypothetical protein; Provisional; Region: PRK11521 1110693007713 hypothetical protein; Provisional; Region: PRK10557 1110693007714 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1110693007715 hypothetical protein; Provisional; Region: PRK10506 1110693007716 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1110693007717 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1110693007718 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1110693007719 dimerization interface [polypeptide binding]; other site 1110693007720 active site 1110693007721 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 1110693007722 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1110693007723 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1110693007724 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1110693007725 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1110693007726 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1110693007727 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1110693007728 putative active site [active] 1110693007729 Ap4A binding site [chemical binding]; other site 1110693007730 nudix motif; other site 1110693007731 putative metal binding site [ion binding]; other site 1110693007732 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1110693007733 putative DNA-binding cleft [nucleotide binding]; other site 1110693007734 putative DNA clevage site; other site 1110693007735 molecular lever; other site 1110693007736 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1110693007737 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1110693007738 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1110693007739 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1110693007740 active site 1110693007741 catalytic tetrad [active] 1110693007742 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1110693007743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693007744 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1110693007745 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1110693007746 putative acyl-acceptor binding pocket; other site 1110693007747 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1110693007748 acyl-activating enzyme (AAE) consensus motif; other site 1110693007749 putative AMP binding site [chemical binding]; other site 1110693007750 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1110693007751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693007752 DNA binding site [nucleotide binding] 1110693007753 domain linker motif; other site 1110693007754 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1110693007755 dimerization interface (closed form) [polypeptide binding]; other site 1110693007756 ligand binding site [chemical binding]; other site 1110693007757 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1110693007758 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1110693007759 active site 1110693007760 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1110693007761 substrate binding site [chemical binding]; other site 1110693007762 catalytic residues [active] 1110693007763 dimer interface [polypeptide binding]; other site 1110693007764 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1110693007765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693007766 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 1110693007767 putative dimerization interface [polypeptide binding]; other site 1110693007768 putative racemase; Provisional; Region: PRK10200 1110693007769 aspartate racemase; Region: asp_race; TIGR00035 1110693007770 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1110693007771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693007772 putative substrate translocation pore; other site 1110693007773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693007774 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1110693007775 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1110693007776 NADP binding site [chemical binding]; other site 1110693007777 homodimer interface [polypeptide binding]; other site 1110693007778 active site 1110693007779 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1110693007780 putative acyltransferase; Provisional; Region: PRK05790 1110693007781 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1110693007782 dimer interface [polypeptide binding]; other site 1110693007783 active site 1110693007784 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1110693007785 serine transporter; Region: stp; TIGR00814 1110693007786 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1110693007787 DNA binding residues [nucleotide binding] 1110693007788 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1110693007789 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1110693007790 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1110693007791 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1110693007792 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1110693007793 transcriptional regulator; Provisional; Region: PRK11906 1110693007794 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1110693007795 DNA binding site [nucleotide binding] 1110693007796 Tetratricopeptide repeat; Region: TPR_2; pfam07719 1110693007797 predicted peptidoglycan-binding enzyme (pseudogene) 1110693007798 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1110693007799 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693007800 DNA binding residues [nucleotide binding] 1110693007801 dimerization interface [polypeptide binding]; other site 1110693007802 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1110693007803 Peptidase family M23; Region: Peptidase_M23; pfam01551 1110693007804 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 1110693007805 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1110693007806 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1110693007807 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 1110693007808 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1110693007809 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 1110693007810 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1110693007811 catalytic loop [active] 1110693007812 iron binding site [ion binding]; other site 1110693007813 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1110693007814 GAF domain; Region: GAF; cl17456 1110693007815 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1110693007816 PAS domain; Region: PAS; smart00091 1110693007817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693007818 Walker A motif; other site 1110693007819 ATP binding site [chemical binding]; other site 1110693007820 Walker B motif; other site 1110693007821 arginine finger; other site 1110693007822 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1110693007823 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 1110693007824 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1110693007825 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1110693007826 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1110693007827 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1110693007828 catalytic residue [active] 1110693007829 peptidase; Reviewed; Region: PRK13004 1110693007830 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 1110693007831 putative metal binding site [ion binding]; other site 1110693007832 putative dimer interface [polypeptide binding]; other site 1110693007833 D-hydantoinase; Region: D-hydantoinase; TIGR02033 1110693007834 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1110693007835 tetramer interface [polypeptide binding]; other site 1110693007836 active site 1110693007837 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1110693007838 carbamate kinase; Reviewed; Region: PRK12686 1110693007839 putative substrate binding site [chemical binding]; other site 1110693007840 homodimer interface [polypeptide binding]; other site 1110693007841 nucleotide binding site [chemical binding]; other site 1110693007842 nucleotide binding site [chemical binding]; other site 1110693007843 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1110693007844 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1110693007845 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1110693007846 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 1110693007847 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1110693007848 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 1110693007849 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1110693007850 Ligand binding site; other site 1110693007851 metal-binding site 1110693007852 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 1110693007853 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1110693007854 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1110693007855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693007856 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 1110693007857 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1110693007858 active site 1110693007859 putative substrate binding pocket [chemical binding]; other site 1110693007860 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 1110693007861 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1110693007862 putative hypoxanthine oxidase; Provisional; Region: PRK09800 1110693007863 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1110693007864 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1110693007865 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1110693007866 uracil-xanthine permease; Region: ncs2; TIGR00801 1110693007867 guanine deaminase; Provisional; Region: PRK09228 1110693007868 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1110693007869 active site 1110693007870 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1110693007871 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1110693007872 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 1110693007873 4Fe-4S binding domain; Region: Fer4; pfam00037 1110693007874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1110693007875 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693007876 xanthine permease; Region: pbuX; TIGR03173 1110693007877 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1110693007878 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1110693007879 active site 1110693007880 metal binding site [ion binding]; metal-binding site 1110693007881 nudix motif; other site 1110693007882 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1110693007883 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1110693007884 dimer interface [polypeptide binding]; other site 1110693007885 putative anticodon binding site; other site 1110693007886 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1110693007887 motif 1; other site 1110693007888 active site 1110693007889 motif 2; other site 1110693007890 motif 3; other site 1110693007891 mutated gene, peptide chain release factor RF-2 1110693007892 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1110693007893 DHH family; Region: DHH; pfam01368 1110693007894 DHHA1 domain; Region: DHHA1; pfam02272 1110693007895 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1110693007896 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1110693007897 dimerization domain [polypeptide binding]; other site 1110693007898 dimer interface [polypeptide binding]; other site 1110693007899 catalytic residues [active] 1110693007900 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1110693007901 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1110693007902 active site 1110693007903 Int/Topo IB signature motif; other site 1110693007904 flavodoxin FldB; Provisional; Region: PRK12359 1110693007905 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1110693007906 hypothetical protein; Provisional; Region: PRK10878 1110693007907 putative global regulator; Reviewed; Region: PRK09559 1110693007908 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1110693007909 hemolysin; Provisional; Region: PRK15087 1110693007910 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1110693007911 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1110693007912 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1110693007913 beta-galactosidase; Region: BGL; TIGR03356 1110693007914 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 1110693007915 classical (c) SDRs; Region: SDR_c; cd05233 1110693007916 NAD(P) binding site [chemical binding]; other site 1110693007917 active site 1110693007918 glycine dehydrogenase; Provisional; Region: PRK05367 1110693007919 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1110693007920 tetramer interface [polypeptide binding]; other site 1110693007921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693007922 catalytic residue [active] 1110693007923 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1110693007924 tetramer interface [polypeptide binding]; other site 1110693007925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693007926 catalytic residue [active] 1110693007927 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1110693007928 lipoyl attachment site [posttranslational modification]; other site 1110693007929 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1110693007930 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1110693007931 oxidoreductase; Provisional; Region: PRK08013 1110693007932 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1110693007933 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1110693007934 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1110693007935 proline aminopeptidase P II; Provisional; Region: PRK10879 1110693007936 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1110693007937 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1110693007938 active site 1110693007939 hypothetical protein; Reviewed; Region: PRK01736 1110693007940 Z-ring-associated protein; Provisional; Region: PRK10972 1110693007941 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1110693007942 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1110693007943 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1110693007944 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1110693007945 ligand binding site [chemical binding]; other site 1110693007946 NAD binding site [chemical binding]; other site 1110693007947 tetramer interface [polypeptide binding]; other site 1110693007948 catalytic site [active] 1110693007949 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1110693007950 L-serine binding site [chemical binding]; other site 1110693007951 ACT domain interface; other site 1110693007952 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1110693007953 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1110693007954 active site 1110693007955 dimer interface [polypeptide binding]; other site 1110693007956 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1110693007957 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1110693007958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693007959 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1110693007960 putative dimerization interface [polypeptide binding]; other site 1110693007961 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1110693007962 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1110693007963 active site 1110693007964 substrate binding site [chemical binding]; other site 1110693007965 coenzyme B12 binding site [chemical binding]; other site 1110693007966 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1110693007967 B12 binding site [chemical binding]; other site 1110693007968 cobalt ligand [ion binding]; other site 1110693007969 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1110693007970 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1110693007971 Walker A; other site 1110693007972 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 1110693007973 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1110693007974 substrate binding site [chemical binding]; other site 1110693007975 oxyanion hole (OAH) forming residues; other site 1110693007976 trimer interface [polypeptide binding]; other site 1110693007977 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1110693007978 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1110693007979 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1110693007980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693007981 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1110693007982 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1110693007983 dimerization interface [polypeptide binding]; other site 1110693007984 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1110693007985 oxidative stress defense protein; Provisional; Region: PRK11087 1110693007986 arginine exporter protein; Provisional; Region: PRK09304 1110693007987 mechanosensitive channel MscS; Provisional; Region: PRK10334 1110693007988 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1110693007989 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1110693007990 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1110693007991 active site 1110693007992 intersubunit interface [polypeptide binding]; other site 1110693007993 zinc binding site [ion binding]; other site 1110693007994 Na+ binding site [ion binding]; other site 1110693007995 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1110693007996 Phosphoglycerate kinase; Region: PGK; pfam00162 1110693007997 substrate binding site [chemical binding]; other site 1110693007998 hinge regions; other site 1110693007999 ADP binding site [chemical binding]; other site 1110693008000 catalytic site [active] 1110693008001 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1110693008002 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1110693008003 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1110693008004 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1110693008005 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1110693008006 active site 1110693008007 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1110693008008 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 1110693008009 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1110693008010 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1110693008011 putative active site [active] 1110693008012 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1110693008013 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1110693008014 putative NAD(P) binding site [chemical binding]; other site 1110693008015 catalytic Zn binding site [ion binding]; other site 1110693008016 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1110693008017 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1110693008018 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1110693008019 active site 1110693008020 P-loop; other site 1110693008021 phosphorylation site [posttranslational modification] 1110693008022 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1110693008023 active site 1110693008024 phosphorylation site [posttranslational modification] 1110693008025 transketolase; Reviewed; Region: PRK12753 1110693008026 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1110693008027 TPP-binding site [chemical binding]; other site 1110693008028 dimer interface [polypeptide binding]; other site 1110693008029 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1110693008030 PYR/PP interface [polypeptide binding]; other site 1110693008031 dimer interface [polypeptide binding]; other site 1110693008032 TPP binding site [chemical binding]; other site 1110693008033 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1110693008034 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1110693008035 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1110693008036 agmatinase; Region: agmatinase; TIGR01230 1110693008037 oligomer interface [polypeptide binding]; other site 1110693008038 putative active site [active] 1110693008039 Mn binding site [ion binding]; other site 1110693008040 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1110693008041 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1110693008042 dimer interface [polypeptide binding]; other site 1110693008043 active site 1110693008044 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1110693008045 catalytic residues [active] 1110693008046 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1110693008047 Virulence promoting factor; Region: YqgB; pfam11036 1110693008048 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 1110693008049 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1110693008050 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1110693008051 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1110693008052 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1110693008053 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1110693008054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693008055 putative substrate translocation pore; other site 1110693008056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693008057 hypothetical protein; Provisional; Region: PRK04860 1110693008058 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1110693008059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1110693008060 RNA methyltransferase, RsmE family; Region: TIGR00046 1110693008061 glutathione synthetase; Provisional; Region: PRK05246 1110693008062 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1110693008063 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1110693008064 hypothetical protein; Validated; Region: PRK00228 1110693008065 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1110693008066 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1110693008067 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1110693008068 Walker A motif; other site 1110693008069 ATP binding site [chemical binding]; other site 1110693008070 Walker B motif; other site 1110693008071 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1110693008072 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1110693008073 catalytic residue [active] 1110693008074 YGGT family; Region: YGGT; pfam02325 1110693008075 YGGT family; Region: YGGT; pfam02325 1110693008076 hypothetical protein; Validated; Region: PRK05090 1110693008077 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1110693008078 active site 1110693008079 dimerization interface [polypeptide binding]; other site 1110693008080 HemN family oxidoreductase; Provisional; Region: PRK05660 1110693008081 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693008082 FeS/SAM binding site; other site 1110693008083 HemN C-terminal domain; Region: HemN_C; pfam06969 1110693008084 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1110693008085 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1110693008086 homodimer interface [polypeptide binding]; other site 1110693008087 active site 1110693008088 hypothetical protein; Provisional; Region: PRK10626 1110693008089 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1110693008090 hypothetical protein; Provisional; Region: PRK11702 1110693008091 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1110693008092 adenine DNA glycosylase; Provisional; Region: PRK10880 1110693008093 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1110693008094 minor groove reading motif; other site 1110693008095 helix-hairpin-helix signature motif; other site 1110693008096 substrate binding pocket [chemical binding]; other site 1110693008097 active site 1110693008098 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1110693008099 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1110693008100 DNA binding and oxoG recognition site [nucleotide binding] 1110693008101 oxidative damage protection protein; Provisional; Region: PRK05408 1110693008102 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1110693008103 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1110693008104 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1110693008105 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1110693008106 catalytic residue [active] 1110693008107 nucleoside transporter; Region: 2A0110; TIGR00889 1110693008108 ornithine decarboxylase; Provisional; Region: PRK13578 1110693008109 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1110693008110 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1110693008111 homodimer interface [polypeptide binding]; other site 1110693008112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693008113 catalytic residue [active] 1110693008114 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1110693008115 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1110693008116 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1110693008117 CHAP domain; Region: CHAP; pfam05257 1110693008118 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1110693008119 putative S-transferase; Provisional; Region: PRK11752 1110693008120 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1110693008121 C-terminal domain interface [polypeptide binding]; other site 1110693008122 GSH binding site (G-site) [chemical binding]; other site 1110693008123 dimer interface [polypeptide binding]; other site 1110693008124 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1110693008125 dimer interface [polypeptide binding]; other site 1110693008126 N-terminal domain interface [polypeptide binding]; other site 1110693008127 active site 1110693008128 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1110693008129 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1110693008130 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 1110693008131 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 1110693008132 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1110693008133 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1110693008134 putative substrate-binding site; other site 1110693008135 nickel binding site [ion binding]; other site 1110693008136 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1110693008137 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1110693008138 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1110693008139 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1110693008140 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1110693008141 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1110693008142 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1110693008143 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1110693008144 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1110693008145 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1110693008146 predicted hydrolase (pseudogene) 1110693008147 predicted dienlactone hydrolase (pseudogene) 1110693008148 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1110693008149 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1110693008150 active site 1110693008151 catalytic tetrad [active] 1110693008152 hypothetical protein; Provisional; Region: PRK05208 1110693008153 oxidoreductase; Provisional; Region: PRK07985 1110693008154 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1110693008155 NAD binding site [chemical binding]; other site 1110693008156 metal binding site [ion binding]; metal-binding site 1110693008157 active site 1110693008158 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1110693008159 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1110693008160 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1110693008161 cystathionine beta-lyase; Provisional; Region: PRK08114 1110693008162 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1110693008163 homodimer interface [polypeptide binding]; other site 1110693008164 substrate-cofactor binding pocket; other site 1110693008165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693008166 catalytic residue [active] 1110693008167 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1110693008168 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1110693008169 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1110693008170 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1110693008171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693008172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693008173 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1110693008174 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1110693008175 dimer interface [polypeptide binding]; other site 1110693008176 active site 1110693008177 metal binding site [ion binding]; metal-binding site 1110693008178 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1110693008179 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1110693008180 active site 1110693008181 catalytic tetrad [active] 1110693008182 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1110693008183 putative outer membrane lipoprotein; Provisional; Region: PRK09973 1110693008184 hypothetical protein; Provisional; Region: PRK01254 1110693008185 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1110693008186 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1110693008187 FtsI repressor; Provisional; Region: PRK10883 1110693008188 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1110693008189 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1110693008190 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1110693008191 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1110693008192 putative acyl-acceptor binding pocket; other site 1110693008193 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 1110693008194 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1110693008195 CAP-like domain; other site 1110693008196 active site 1110693008197 primary dimer interface [polypeptide binding]; other site 1110693008198 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1110693008199 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 1110693008200 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1110693008201 peptide binding site [polypeptide binding]; other site 1110693008202 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1110693008203 toxin interface [polypeptide binding]; other site 1110693008204 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1110693008205 Zn binding site [ion binding]; other site 1110693008206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1110693008207 non-specific DNA binding site [nucleotide binding]; other site 1110693008208 salt bridge; other site 1110693008209 sequence-specific DNA binding site [nucleotide binding]; other site 1110693008210 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 1110693008211 peptide binding site [polypeptide binding]; other site 1110693008212 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1110693008213 TIGR00156 family protein; Region: TIGR00156 1110693008214 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1110693008215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693008216 active site 1110693008217 phosphorylation site [posttranslational modification] 1110693008218 intermolecular recognition site; other site 1110693008219 dimerization interface [polypeptide binding]; other site 1110693008220 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693008221 DNA binding site [nucleotide binding] 1110693008222 sensor protein QseC; Provisional; Region: PRK10337 1110693008223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693008224 dimer interface [polypeptide binding]; other site 1110693008225 phosphorylation site [posttranslational modification] 1110693008226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693008227 ATP binding site [chemical binding]; other site 1110693008228 Mg2+ binding site [ion binding]; other site 1110693008229 G-X-G motif; other site 1110693008230 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1110693008231 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1110693008232 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1110693008233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693008234 ATP binding site [chemical binding]; other site 1110693008235 Mg2+ binding site [ion binding]; other site 1110693008236 G-X-G motif; other site 1110693008237 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1110693008238 anchoring element; other site 1110693008239 dimer interface [polypeptide binding]; other site 1110693008240 ATP binding site [chemical binding]; other site 1110693008241 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1110693008242 active site 1110693008243 metal binding site [ion binding]; metal-binding site 1110693008244 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1110693008245 esterase YqiA; Provisional; Region: PRK11071 1110693008246 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1110693008247 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1110693008248 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1110693008249 active site 1110693008250 metal binding site [ion binding]; metal-binding site 1110693008251 hexamer interface [polypeptide binding]; other site 1110693008252 putative dehydrogenase; Provisional; Region: PRK11039 1110693008253 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1110693008254 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1110693008255 dimer interface [polypeptide binding]; other site 1110693008256 ADP-ribose binding site [chemical binding]; other site 1110693008257 active site 1110693008258 nudix motif; other site 1110693008259 metal binding site [ion binding]; metal-binding site 1110693008260 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1110693008261 hypothetical protein; Provisional; Region: PRK11653 1110693008262 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1110693008263 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1110693008264 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1110693008265 putative active site [active] 1110693008266 metal binding site [ion binding]; metal-binding site 1110693008267 zinc transporter ZupT; Provisional; Region: PRK04201 1110693008268 ZIP Zinc transporter; Region: Zip; pfam02535 1110693008269 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1110693008270 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1110693008271 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 1110693008272 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 1110693008273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1110693008274 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1110693008275 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1110693008276 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1110693008277 putative ribose interaction site [chemical binding]; other site 1110693008278 putative ADP binding site [chemical binding]; other site 1110693008279 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1110693008280 active site 1110693008281 nucleotide binding site [chemical binding]; other site 1110693008282 HIGH motif; other site 1110693008283 KMSKS motif; other site 1110693008284 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1110693008285 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1110693008286 metal binding triad; other site 1110693008287 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1110693008288 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1110693008289 metal binding triad; other site 1110693008290 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1110693008291 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1110693008292 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1110693008293 putative active site [active] 1110693008294 putative metal binding residues [ion binding]; other site 1110693008295 signature motif; other site 1110693008296 putative triphosphate binding site [ion binding]; other site 1110693008297 CHAD domain; Region: CHAD; pfam05235 1110693008298 SH3 domain-containing protein; Provisional; Region: PRK10884 1110693008299 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1110693008300 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1110693008301 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1110693008302 active site 1110693008303 NTP binding site [chemical binding]; other site 1110693008304 metal binding triad [ion binding]; metal-binding site 1110693008305 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1110693008306 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1110693008307 Zn2+ binding site [ion binding]; other site 1110693008308 Mg2+ binding site [ion binding]; other site 1110693008309 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1110693008310 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1110693008311 homooctamer interface [polypeptide binding]; other site 1110693008312 active site 1110693008313 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1110693008314 transcriptional activator TtdR; Provisional; Region: PRK09801 1110693008315 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693008316 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1110693008317 putative effector binding pocket; other site 1110693008318 putative dimerization interface [polypeptide binding]; other site 1110693008319 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1110693008320 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1110693008321 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1110693008322 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1110693008323 transmembrane helices; other site 1110693008324 UGMP family protein; Validated; Region: PRK09604 1110693008325 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1110693008326 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1110693008327 DNA primase; Validated; Region: dnaG; PRK05667 1110693008328 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1110693008329 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1110693008330 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1110693008331 active site 1110693008332 metal binding site [ion binding]; metal-binding site 1110693008333 interdomain interaction site; other site 1110693008334 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1110693008335 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1110693008336 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1110693008337 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1110693008338 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1110693008339 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1110693008340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1110693008341 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1110693008342 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1110693008343 DNA binding residues [nucleotide binding] 1110693008344 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1110693008345 active site 1110693008346 SUMO-1 interface [polypeptide binding]; other site 1110693008347 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1110693008348 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1110693008349 FAD binding pocket [chemical binding]; other site 1110693008350 FAD binding motif [chemical binding]; other site 1110693008351 phosphate binding motif [ion binding]; other site 1110693008352 NAD binding pocket [chemical binding]; other site 1110693008353 Predicted transcriptional regulators [Transcription]; Region: COG1695 1110693008354 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1110693008355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1110693008356 PAS fold; Region: PAS_3; pfam08447 1110693008357 putative active site [active] 1110693008358 heme pocket [chemical binding]; other site 1110693008359 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1110693008360 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1110693008361 dimer interface [polypeptide binding]; other site 1110693008362 putative CheW interface [polypeptide binding]; other site 1110693008363 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1110693008364 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1110693008365 inhibitor-cofactor binding pocket; inhibition site 1110693008366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693008367 catalytic residue [active] 1110693008368 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1110693008369 dimer interface [polypeptide binding]; other site 1110693008370 putative tRNA-binding site [nucleotide binding]; other site 1110693008371 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1110693008372 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693008373 DNA binding site [nucleotide binding] 1110693008374 domain linker motif; other site 1110693008375 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1110693008376 putative dimerization interface [polypeptide binding]; other site 1110693008377 putative ligand binding site [chemical binding]; other site 1110693008378 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1110693008379 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1110693008380 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1110693008381 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1110693008382 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1110693008383 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 1110693008384 inner membrane transporter YjeM; Provisional; Region: PRK15238 1110693008385 alpha-glucosidase; Provisional; Region: PRK10137 1110693008386 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1110693008387 Trehalase; Region: Trehalase; cl17346 1110693008388 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1110693008389 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1110693008390 active site 1110693008391 FMN binding site [chemical binding]; other site 1110693008392 2,4-decadienoyl-CoA binding site; other site 1110693008393 catalytic residue [active] 1110693008394 4Fe-4S cluster binding site [ion binding]; other site 1110693008395 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1110693008396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1110693008397 non-specific DNA binding site [nucleotide binding]; other site 1110693008398 salt bridge; other site 1110693008399 sequence-specific DNA binding site [nucleotide binding]; other site 1110693008400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 1110693008401 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1110693008402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693008403 S-adenosylmethionine binding site [chemical binding]; other site 1110693008404 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1110693008405 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1110693008406 putative active site [active] 1110693008407 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1110693008408 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1110693008409 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1110693008410 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1110693008411 serine/threonine transporter SstT; Provisional; Region: PRK13628 1110693008412 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1110693008413 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1110693008414 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1110693008415 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1110693008416 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1110693008417 Glucuronate isomerase; Region: UxaC; pfam02614 1110693008418 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1110693008419 D-galactonate transporter; Region: 2A0114; TIGR00893 1110693008420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693008421 putative substrate translocation pore; other site 1110693008422 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1110693008423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693008424 DNA-binding site [nucleotide binding]; DNA binding site 1110693008425 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1110693008426 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1110693008427 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1110693008428 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1110693008429 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1110693008430 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1110693008431 Predicted membrane protein [Function unknown]; Region: COG5393 1110693008432 YqjK-like protein; Region: YqjK; pfam13997 1110693008433 Predicted membrane protein [Function unknown]; Region: COG2259 1110693008434 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1110693008435 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1110693008436 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1110693008437 putative dimer interface [polypeptide binding]; other site 1110693008438 N-terminal domain interface [polypeptide binding]; other site 1110693008439 putative substrate binding pocket (H-site) [chemical binding]; other site 1110693008440 Predicted membrane protein [Function unknown]; Region: COG3152 1110693008441 Predicted membrane protein [Function unknown]; Region: COG3152 1110693008442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693008443 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1110693008444 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1110693008445 dimerization interface [polypeptide binding]; other site 1110693008446 Pirin-related protein [General function prediction only]; Region: COG1741 1110693008447 Pirin; Region: Pirin; pfam02678 1110693008448 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1110693008449 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1110693008450 serine transporter; Region: stp; TIGR00814 1110693008451 L-serine dehydratase TdcG; Provisional; Region: PRK15040 1110693008452 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1110693008453 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1110693008454 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1110693008455 homotrimer interaction site [polypeptide binding]; other site 1110693008456 putative active site [active] 1110693008457 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1110693008458 Pyruvate formate lyase 1; Region: PFL1; cd01678 1110693008459 coenzyme A binding site [chemical binding]; other site 1110693008460 active site 1110693008461 catalytic residues [active] 1110693008462 glycine loop; other site 1110693008463 propionate/acetate kinase; Provisional; Region: PRK12379 1110693008464 Acetokinase family; Region: Acetate_kinase; cl17229 1110693008465 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1110693008466 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1110693008467 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1110693008468 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1110693008469 tetramer interface [polypeptide binding]; other site 1110693008470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693008471 catalytic residue [active] 1110693008472 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 1110693008473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693008474 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1110693008475 putative substrate binding pocket [chemical binding]; other site 1110693008476 putative dimerization interface [polypeptide binding]; other site 1110693008477 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 1110693008478 hypothetical protein; Provisional; Region: PRK09716 1110693008479 glycerate kinase I; Provisional; Region: PRK10342 1110693008480 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1110693008481 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1110693008482 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1110693008483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693008484 D-galactonate transporter; Region: 2A0114; TIGR00893 1110693008485 putative substrate translocation pore; other site 1110693008486 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1110693008487 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1110693008488 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1110693008489 putative regulator PrlF; Provisional; Region: PRK09974 1110693008490 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1110693008491 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 1110693008492 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 1110693008493 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1110693008494 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1110693008495 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 1110693008496 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1110693008497 active site 1110693008498 phosphorylation site [posttranslational modification] 1110693008499 N-acetylgalactosamine-specific enzyme IIC component of PTS, fragment (pseudogene) 1110693008500 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1110693008501 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1110693008502 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1110693008503 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1110693008504 dimer interface [polypeptide binding]; other site 1110693008505 active site 1110693008506 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1110693008507 putative active site [active] 1110693008508 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 1110693008509 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1110693008510 active site 1110693008511 intersubunit interface [polypeptide binding]; other site 1110693008512 zinc binding site [ion binding]; other site 1110693008513 Na+ binding site [ion binding]; other site 1110693008514 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1110693008515 active site 1110693008516 phosphorylation site [posttranslational modification] 1110693008517 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 1110693008518 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 1110693008519 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1110693008520 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1110693008521 active site 1110693008522 trimer interface [polypeptide binding]; other site 1110693008523 allosteric site; other site 1110693008524 active site lid [active] 1110693008525 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1110693008526 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1110693008527 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1110693008528 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1110693008529 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1110693008530 PapC N-terminal domain; Region: PapC_N; pfam13954 1110693008531 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1110693008532 PapC C-terminal domain; Region: PapC_C; pfam13953 1110693008533 Fimbrial protein; Region: Fimbrial; pfam00419 1110693008534 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1110693008535 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1110693008536 putative SAM binding site [chemical binding]; other site 1110693008537 putative homodimer interface [polypeptide binding]; other site 1110693008538 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1110693008539 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1110693008540 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1110693008541 putative ligand binding site [chemical binding]; other site 1110693008542 TIGR00252 family protein; Region: TIGR00252 1110693008543 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1110693008544 dimer interface [polypeptide binding]; other site 1110693008545 active site 1110693008546 outer membrane lipoprotein; Provisional; Region: PRK11023 1110693008547 BON domain; Region: BON; pfam04972 1110693008548 BON domain; Region: BON; pfam04972 1110693008549 Predicted permease; Region: DUF318; pfam03773 1110693008550 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1110693008551 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1110693008552 NAD binding site [chemical binding]; other site 1110693008553 active site 1110693008554 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1110693008555 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1110693008556 proposed catalytic triad [active] 1110693008557 conserved cys residue [active] 1110693008558 hypothetical protein; Provisional; Region: PRK03467 1110693008559 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1110693008560 GIY-YIG motif/motif A; other site 1110693008561 putative active site [active] 1110693008562 putative metal binding site [ion binding]; other site 1110693008563 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1110693008564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1110693008565 Coenzyme A binding pocket [chemical binding]; other site 1110693008566 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1110693008567 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1110693008568 Peptidase family U32; Region: Peptidase_U32; pfam01136 1110693008569 putative protease; Provisional; Region: PRK15447 1110693008570 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1110693008571 hypothetical protein; Provisional; Region: PRK10508 1110693008572 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1110693008573 tryptophan permease; Provisional; Region: PRK10483 1110693008574 aromatic amino acid transport protein; Region: araaP; TIGR00837 1110693008575 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 1110693008576 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1110693008577 ATP binding site [chemical binding]; other site 1110693008578 Mg++ binding site [ion binding]; other site 1110693008579 motif III; other site 1110693008580 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1110693008581 nucleotide binding region [chemical binding]; other site 1110693008582 ATP-binding site [chemical binding]; other site 1110693008583 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1110693008584 putative RNA binding site [nucleotide binding]; other site 1110693008585 lipoprotein NlpI; Provisional; Region: PRK11189 1110693008586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1110693008587 binding surface 1110693008588 TPR motif; other site 1110693008589 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1110693008590 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1110693008591 RNase E interface [polypeptide binding]; other site 1110693008592 trimer interface [polypeptide binding]; other site 1110693008593 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1110693008594 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1110693008595 RNase E interface [polypeptide binding]; other site 1110693008596 trimer interface [polypeptide binding]; other site 1110693008597 active site 1110693008598 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1110693008599 putative nucleic acid binding region [nucleotide binding]; other site 1110693008600 G-X-X-G motif; other site 1110693008601 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1110693008602 RNA binding site [nucleotide binding]; other site 1110693008603 domain interface; other site 1110693008604 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1110693008605 16S/18S rRNA binding site [nucleotide binding]; other site 1110693008606 S13e-L30e interaction site [polypeptide binding]; other site 1110693008607 25S rRNA binding site [nucleotide binding]; other site 1110693008608 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1110693008609 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1110693008610 RNA binding site [nucleotide binding]; other site 1110693008611 active site 1110693008612 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1110693008613 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1110693008614 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1110693008615 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1110693008616 translation initiation factor IF-2; Region: IF-2; TIGR00487 1110693008617 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1110693008618 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1110693008619 G1 box; other site 1110693008620 putative GEF interaction site [polypeptide binding]; other site 1110693008621 GTP/Mg2+ binding site [chemical binding]; other site 1110693008622 Switch I region; other site 1110693008623 G2 box; other site 1110693008624 G3 box; other site 1110693008625 Switch II region; other site 1110693008626 G4 box; other site 1110693008627 G5 box; other site 1110693008628 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1110693008629 Translation-initiation factor 2; Region: IF-2; pfam11987 1110693008630 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1110693008631 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1110693008632 NusA N-terminal domain; Region: NusA_N; pfam08529 1110693008633 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1110693008634 RNA binding site [nucleotide binding]; other site 1110693008635 homodimer interface [polypeptide binding]; other site 1110693008636 NusA-like KH domain; Region: KH_5; pfam13184 1110693008637 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1110693008638 G-X-X-G motif; other site 1110693008639 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1110693008640 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1110693008641 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1110693008642 Sm and related proteins; Region: Sm_like; cl00259 1110693008643 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1110693008644 putative oligomer interface [polypeptide binding]; other site 1110693008645 putative RNA binding site [nucleotide binding]; other site 1110693008646 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1110693008647 ANP binding site [chemical binding]; other site 1110693008648 Substrate Binding Site II [chemical binding]; other site 1110693008649 Substrate Binding Site I [chemical binding]; other site 1110693008650 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1110693008651 Sulfatase; Region: Sulfatase; pfam00884 1110693008652 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1110693008653 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1110693008654 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1110693008655 active site 1110693008656 substrate binding site [chemical binding]; other site 1110693008657 metal binding site [ion binding]; metal-binding site 1110693008658 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1110693008659 dihydropteroate synthase; Region: DHPS; TIGR01496 1110693008660 substrate binding pocket [chemical binding]; other site 1110693008661 dimer interface [polypeptide binding]; other site 1110693008662 inhibitor binding site; inhibition site 1110693008663 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1110693008664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693008665 Walker A motif; other site 1110693008666 ATP binding site [chemical binding]; other site 1110693008667 Walker B motif; other site 1110693008668 arginine finger; other site 1110693008669 Peptidase family M41; Region: Peptidase_M41; pfam01434 1110693008670 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1110693008671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693008672 S-adenosylmethionine binding site [chemical binding]; other site 1110693008673 RNA-binding protein YhbY; Provisional; Region: PRK10343 1110693008674 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1110693008675 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1110693008676 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1110693008677 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1110693008678 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1110693008679 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1110693008680 GTP1/OBG; Region: GTP1_OBG; pfam01018 1110693008681 Obg GTPase; Region: Obg; cd01898 1110693008682 G1 box; other site 1110693008683 GTP/Mg2+ binding site [chemical binding]; other site 1110693008684 Switch I region; other site 1110693008685 G2 box; other site 1110693008686 G3 box; other site 1110693008687 Switch II region; other site 1110693008688 G4 box; other site 1110693008689 G5 box; other site 1110693008690 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1110693008691 EamA-like transporter family; Region: EamA; pfam00892 1110693008692 EamA-like transporter family; Region: EamA; pfam00892 1110693008693 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1110693008694 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1110693008695 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1110693008696 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1110693008697 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1110693008698 substrate binding pocket [chemical binding]; other site 1110693008699 chain length determination region; other site 1110693008700 substrate-Mg2+ binding site; other site 1110693008701 catalytic residues [active] 1110693008702 aspartate-rich region 1; other site 1110693008703 active site lid residues [active] 1110693008704 aspartate-rich region 2; other site 1110693008705 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1110693008706 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1110693008707 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1110693008708 hinge; other site 1110693008709 active site 1110693008710 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1110693008711 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1110693008712 anti sigma factor interaction site; other site 1110693008713 regulatory phosphorylation site [posttranslational modification]; other site 1110693008714 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1110693008715 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1110693008716 mce related protein; Region: MCE; pfam02470 1110693008717 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1110693008718 conserved hypothetical integral membrane protein; Region: TIGR00056 1110693008719 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1110693008720 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1110693008721 Walker A/P-loop; other site 1110693008722 ATP binding site [chemical binding]; other site 1110693008723 Q-loop/lid; other site 1110693008724 ABC transporter signature motif; other site 1110693008725 Walker B; other site 1110693008726 D-loop; other site 1110693008727 H-loop/switch region; other site 1110693008728 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1110693008729 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1110693008730 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1110693008731 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1110693008732 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1110693008733 putative active site [active] 1110693008734 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1110693008735 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1110693008736 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1110693008737 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1110693008738 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1110693008739 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1110693008740 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1110693008741 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1110693008742 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1110693008743 Walker A/P-loop; other site 1110693008744 ATP binding site [chemical binding]; other site 1110693008745 Q-loop/lid; other site 1110693008746 ABC transporter signature motif; other site 1110693008747 Walker B; other site 1110693008748 D-loop; other site 1110693008749 H-loop/switch region; other site 1110693008750 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1110693008751 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1110693008752 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1110693008753 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1110693008754 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1110693008755 30S subunit binding site; other site 1110693008756 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1110693008757 active site 1110693008758 phosphorylation site [posttranslational modification] 1110693008759 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1110693008760 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1110693008761 dimerization domain swap beta strand [polypeptide binding]; other site 1110693008762 regulatory protein interface [polypeptide binding]; other site 1110693008763 active site 1110693008764 regulatory phosphorylation site [posttranslational modification]; other site 1110693008765 hypothetical protein; Provisional; Region: PRK10345 1110693008766 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1110693008767 Transglycosylase; Region: Transgly; cl17702 1110693008768 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1110693008769 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1110693008770 conserved cys residue [active] 1110693008771 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1110693008772 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1110693008773 putative active site [active] 1110693008774 heme pocket [chemical binding]; other site 1110693008775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693008776 dimer interface [polypeptide binding]; other site 1110693008777 phosphorylation site [posttranslational modification] 1110693008778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693008779 ATP binding site [chemical binding]; other site 1110693008780 Mg2+ binding site [ion binding]; other site 1110693008781 G-X-G motif; other site 1110693008782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693008783 active site 1110693008784 phosphorylation site [posttranslational modification] 1110693008785 intermolecular recognition site; other site 1110693008786 dimerization interface [polypeptide binding]; other site 1110693008787 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1110693008788 putative binding surface; other site 1110693008789 active site 1110693008790 radical SAM protein, TIGR01212 family; Region: TIGR01212 1110693008791 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693008792 FeS/SAM binding site; other site 1110693008793 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1110693008794 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1110693008795 active site 1110693008796 dimer interface [polypeptide binding]; other site 1110693008797 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1110693008798 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1110693008799 active site 1110693008800 FMN binding site [chemical binding]; other site 1110693008801 substrate binding site [chemical binding]; other site 1110693008802 3Fe-4S cluster binding site [ion binding]; other site 1110693008803 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1110693008804 domain interface; other site 1110693008805 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1110693008806 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1110693008807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693008808 Protein of unknown function (DUF1120); Region: DUF1120; pfam06551 1110693008809 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1110693008810 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1110693008811 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 1110693008812 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1110693008813 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1110693008814 nucleotide binding site [chemical binding]; other site 1110693008815 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1110693008816 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1110693008817 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1110693008818 putative active site cavity [active] 1110693008819 putative sialic acid transporter; Provisional; Region: PRK03893 1110693008820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693008821 putative substrate translocation pore; other site 1110693008822 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1110693008823 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1110693008824 inhibitor site; inhibition site 1110693008825 active site 1110693008826 dimer interface [polypeptide binding]; other site 1110693008827 catalytic residue [active] 1110693008828 transcriptional regulator NanR; Provisional; Region: PRK03837 1110693008829 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693008830 DNA-binding site [nucleotide binding]; DNA binding site 1110693008831 FCD domain; Region: FCD; pfam07729 1110693008832 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 1110693008833 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1110693008834 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1110693008835 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1110693008836 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1110693008837 C-terminal domain interface [polypeptide binding]; other site 1110693008838 putative GSH binding site (G-site) [chemical binding]; other site 1110693008839 dimer interface [polypeptide binding]; other site 1110693008840 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1110693008841 dimer interface [polypeptide binding]; other site 1110693008842 N-terminal domain interface [polypeptide binding]; other site 1110693008843 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1110693008844 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1110693008845 23S rRNA interface [nucleotide binding]; other site 1110693008846 L3 interface [polypeptide binding]; other site 1110693008847 Predicted ATPase [General function prediction only]; Region: COG1485 1110693008848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1110693008849 hypothetical protein; Provisional; Region: PRK11677 1110693008850 serine endoprotease; Provisional; Region: PRK10139 1110693008851 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1110693008852 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1110693008853 protein binding site [polypeptide binding]; other site 1110693008854 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1110693008855 serine endoprotease; Provisional; Region: PRK10898 1110693008856 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1110693008857 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1110693008858 malate dehydrogenase; Provisional; Region: PRK05086 1110693008859 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1110693008860 NAD binding site [chemical binding]; other site 1110693008861 dimerization interface [polypeptide binding]; other site 1110693008862 Substrate binding site [chemical binding]; other site 1110693008863 arginine repressor; Provisional; Region: PRK05066 1110693008864 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1110693008865 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1110693008866 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1110693008867 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1110693008868 RNAase interaction site [polypeptide binding]; other site 1110693008869 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1110693008870 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1110693008871 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1110693008872 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693008873 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693008874 efflux system membrane protein; Provisional; Region: PRK11594 1110693008875 transcriptional regulator; Provisional; Region: PRK10632 1110693008876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693008877 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1110693008878 putative effector binding pocket; other site 1110693008879 dimerization interface [polypeptide binding]; other site 1110693008880 protease TldD; Provisional; Region: tldD; PRK10735 1110693008881 hypothetical protein; Provisional; Region: PRK10899 1110693008882 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1110693008883 ribonuclease G; Provisional; Region: PRK11712 1110693008884 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1110693008885 homodimer interface [polypeptide binding]; other site 1110693008886 oligonucleotide binding site [chemical binding]; other site 1110693008887 Maf-like protein; Region: Maf; pfam02545 1110693008888 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1110693008889 active site 1110693008890 dimer interface [polypeptide binding]; other site 1110693008891 rod shape-determining protein MreD; Provisional; Region: PRK11060 1110693008892 rod shape-determining protein MreC; Region: mreC; TIGR00219 1110693008893 rod shape-determining protein MreC; Region: MreC; pfam04085 1110693008894 rod shape-determining protein MreB; Provisional; Region: PRK13927 1110693008895 MreB and similar proteins; Region: MreB_like; cd10225 1110693008896 nucleotide binding site [chemical binding]; other site 1110693008897 Mg binding site [ion binding]; other site 1110693008898 putative protofilament interaction site [polypeptide binding]; other site 1110693008899 RodZ interaction site [polypeptide binding]; other site 1110693008900 regulatory protein CsrD; Provisional; Region: PRK11059 1110693008901 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693008902 metal binding site [ion binding]; metal-binding site 1110693008903 active site 1110693008904 I-site; other site 1110693008905 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1110693008906 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1110693008907 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1110693008908 NADP binding site [chemical binding]; other site 1110693008909 dimer interface [polypeptide binding]; other site 1110693008910 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1110693008911 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1110693008912 carboxyltransferase (CT) interaction site; other site 1110693008913 biotinylation site [posttranslational modification]; other site 1110693008914 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1110693008915 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1110693008916 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1110693008917 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1110693008918 hypothetical protein; Provisional; Region: PRK10633 1110693008919 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1110693008920 Na binding site [ion binding]; other site 1110693008921 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1110693008922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1110693008923 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1110693008924 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1110693008925 FMN binding site [chemical binding]; other site 1110693008926 active site 1110693008927 catalytic residues [active] 1110693008928 substrate binding site [chemical binding]; other site 1110693008929 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1110693008930 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1110693008931 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1110693008932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693008933 DNA methylase; Region: N6_N4_Mtase; pfam01555 1110693008934 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1110693008935 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1110693008936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1110693008937 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1110693008938 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1110693008939 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693008940 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693008941 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1110693008942 Protein export membrane protein; Region: SecD_SecF; cl14618 1110693008943 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1110693008944 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1110693008945 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693008946 substrate binding pocket [chemical binding]; other site 1110693008947 membrane-bound complex binding site; other site 1110693008948 hinge residues; other site 1110693008949 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1110693008950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693008951 conserved gate region; other site 1110693008952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693008953 dimer interface [polypeptide binding]; other site 1110693008954 conserved gate region; other site 1110693008955 putative PBP binding loops; other site 1110693008956 ABC-ATPase subunit interface; other site 1110693008957 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1110693008958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693008959 dimer interface [polypeptide binding]; other site 1110693008960 conserved gate region; other site 1110693008961 putative PBP binding loops; other site 1110693008962 ABC-ATPase subunit interface; other site 1110693008963 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1110693008964 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1110693008965 Walker A/P-loop; other site 1110693008966 ATP binding site [chemical binding]; other site 1110693008967 Q-loop/lid; other site 1110693008968 ABC transporter signature motif; other site 1110693008969 Walker B; other site 1110693008970 D-loop; other site 1110693008971 H-loop/switch region; other site 1110693008972 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1110693008973 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1110693008974 trimer interface [polypeptide binding]; other site 1110693008975 putative metal binding site [ion binding]; other site 1110693008976 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1110693008977 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1110693008978 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1110693008979 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1110693008980 shikimate binding site; other site 1110693008981 NAD(P) binding site [chemical binding]; other site 1110693008982 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1110693008983 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1110693008984 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1110693008985 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1110693008986 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1110693008987 hypothetical protein; Validated; Region: PRK03430 1110693008988 hypothetical protein; Provisional; Region: PRK10736 1110693008989 DNA protecting protein DprA; Region: dprA; TIGR00732 1110693008990 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1110693008991 active site 1110693008992 catalytic residues [active] 1110693008993 metal binding site [ion binding]; metal-binding site 1110693008994 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1110693008995 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1110693008996 putative active site [active] 1110693008997 substrate binding site [chemical binding]; other site 1110693008998 putative cosubstrate binding site; other site 1110693008999 catalytic site [active] 1110693009000 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1110693009001 substrate binding site [chemical binding]; other site 1110693009002 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1110693009003 putative RNA binding site [nucleotide binding]; other site 1110693009004 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1110693009005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693009006 S-adenosylmethionine binding site [chemical binding]; other site 1110693009007 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1110693009008 TrkA-N domain; Region: TrkA_N; pfam02254 1110693009009 TrkA-C domain; Region: TrkA_C; pfam02080 1110693009010 TrkA-N domain; Region: TrkA_N; pfam02254 1110693009011 TrkA-C domain; Region: TrkA_C; pfam02080 1110693009012 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1110693009013 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1110693009014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1110693009015 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1110693009016 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1110693009017 DNA binding residues [nucleotide binding] 1110693009018 dimer interface [polypeptide binding]; other site 1110693009019 metal binding site [ion binding]; metal-binding site 1110693009020 hypothetical protein; Provisional; Region: PRK10203 1110693009021 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1110693009022 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1110693009023 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1110693009024 alphaNTD homodimer interface [polypeptide binding]; other site 1110693009025 alphaNTD - beta interaction site [polypeptide binding]; other site 1110693009026 alphaNTD - beta' interaction site [polypeptide binding]; other site 1110693009027 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1110693009028 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1110693009029 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1110693009030 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1110693009031 RNA binding surface [nucleotide binding]; other site 1110693009032 30S ribosomal protein S11; Validated; Region: PRK05309 1110693009033 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1110693009034 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1110693009035 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1110693009036 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1110693009037 SecY translocase; Region: SecY; pfam00344 1110693009038 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1110693009039 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1110693009040 23S rRNA binding site [nucleotide binding]; other site 1110693009041 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1110693009042 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1110693009043 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1110693009044 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1110693009045 23S rRNA interface [nucleotide binding]; other site 1110693009046 5S rRNA interface [nucleotide binding]; other site 1110693009047 L27 interface [polypeptide binding]; other site 1110693009048 L5 interface [polypeptide binding]; other site 1110693009049 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1110693009050 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1110693009051 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1110693009052 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1110693009053 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1110693009054 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1110693009055 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1110693009056 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1110693009057 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1110693009058 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1110693009059 RNA binding site [nucleotide binding]; other site 1110693009060 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1110693009061 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1110693009062 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1110693009063 23S rRNA interface [nucleotide binding]; other site 1110693009064 putative translocon interaction site; other site 1110693009065 signal recognition particle (SRP54) interaction site; other site 1110693009066 L23 interface [polypeptide binding]; other site 1110693009067 trigger factor interaction site; other site 1110693009068 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1110693009069 23S rRNA interface [nucleotide binding]; other site 1110693009070 5S rRNA interface [nucleotide binding]; other site 1110693009071 putative antibiotic binding site [chemical binding]; other site 1110693009072 L25 interface [polypeptide binding]; other site 1110693009073 L27 interface [polypeptide binding]; other site 1110693009074 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1110693009075 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1110693009076 G-X-X-G motif; other site 1110693009077 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1110693009078 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1110693009079 protein-rRNA interface [nucleotide binding]; other site 1110693009080 putative translocon binding site; other site 1110693009081 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1110693009082 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1110693009083 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1110693009084 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1110693009085 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1110693009086 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1110693009087 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1110693009088 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1110693009089 protein secretion protein GspB; Provisional; Region: PRK09697 1110693009090 elongation factor Tu; Reviewed; Region: PRK00049 1110693009091 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1110693009092 G1 box; other site 1110693009093 GEF interaction site [polypeptide binding]; other site 1110693009094 GTP/Mg2+ binding site [chemical binding]; other site 1110693009095 Switch I region; other site 1110693009096 G2 box; other site 1110693009097 G3 box; other site 1110693009098 Switch II region; other site 1110693009099 G4 box; other site 1110693009100 G5 box; other site 1110693009101 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1110693009102 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1110693009103 Antibiotic Binding Site [chemical binding]; other site 1110693009104 elongation factor G; Reviewed; Region: PRK00007 1110693009105 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1110693009106 G1 box; other site 1110693009107 putative GEF interaction site [polypeptide binding]; other site 1110693009108 GTP/Mg2+ binding site [chemical binding]; other site 1110693009109 Switch I region; other site 1110693009110 G2 box; other site 1110693009111 G3 box; other site 1110693009112 Switch II region; other site 1110693009113 G4 box; other site 1110693009114 G5 box; other site 1110693009115 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1110693009116 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1110693009117 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1110693009118 30S ribosomal protein S7; Validated; Region: PRK05302 1110693009119 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1110693009120 S17 interaction site [polypeptide binding]; other site 1110693009121 S8 interaction site; other site 1110693009122 16S rRNA interaction site [nucleotide binding]; other site 1110693009123 streptomycin interaction site [chemical binding]; other site 1110693009124 23S rRNA interaction site [nucleotide binding]; other site 1110693009125 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1110693009126 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1110693009127 sulfur relay protein TusC; Validated; Region: PRK00211 1110693009128 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1110693009129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1110693009130 YheO-like PAS domain; Region: PAS_6; pfam08348 1110693009131 HTH domain; Region: HTH_22; pfam13309 1110693009132 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1110693009133 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1110693009134 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1110693009135 phi X174 lysis protein; Provisional; Region: PRK02793 1110693009136 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1110693009137 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1110693009138 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1110693009139 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1110693009140 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1110693009141 TrkA-N domain; Region: TrkA_N; pfam02254 1110693009142 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1110693009143 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1110693009144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693009145 Walker A/P-loop; other site 1110693009146 ATP binding site [chemical binding]; other site 1110693009147 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1110693009148 ABC transporter signature motif; other site 1110693009149 Walker B; other site 1110693009150 D-loop; other site 1110693009151 ABC transporter; Region: ABC_tran_2; pfam12848 1110693009152 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1110693009153 putative hydrolase; Provisional; Region: PRK10985 1110693009154 hypothetical protein; Provisional; Region: PRK04966 1110693009155 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1110693009156 active site 1110693009157 hypothetical protein; Provisional; Region: PRK10738 1110693009158 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1110693009159 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1110693009160 ligand binding site [chemical binding]; other site 1110693009161 flexible hinge region; other site 1110693009162 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1110693009163 putative switch regulator; other site 1110693009164 non-specific DNA interactions [nucleotide binding]; other site 1110693009165 DNA binding site [nucleotide binding] 1110693009166 sequence specific DNA binding site [nucleotide binding]; other site 1110693009167 putative cAMP binding site [chemical binding]; other site 1110693009168 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1110693009169 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1110693009170 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1110693009171 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1110693009172 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1110693009173 inhibitor-cofactor binding pocket; inhibition site 1110693009174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693009175 catalytic residue [active] 1110693009176 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1110693009177 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1110693009178 glutamine binding [chemical binding]; other site 1110693009179 catalytic triad [active] 1110693009180 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1110693009181 cell filamentation protein Fic; Provisional; Region: PRK10347 1110693009182 hypothetical protein; Provisional; Region: PRK10204 1110693009183 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1110693009184 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1110693009185 substrate binding site [chemical binding]; other site 1110693009186 putative transporter; Provisional; Region: PRK03699 1110693009187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693009188 putative substrate translocation pore; other site 1110693009189 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1110693009190 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693009191 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1110693009192 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1110693009193 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1110693009194 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1110693009195 nitrite transporter NirC; Provisional; Region: PRK11562 1110693009196 siroheme synthase; Provisional; Region: cysG; PRK10637 1110693009197 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1110693009198 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1110693009199 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1110693009200 active site 1110693009201 SAM binding site [chemical binding]; other site 1110693009202 homodimer interface [polypeptide binding]; other site 1110693009203 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1110693009204 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1110693009205 hypothetical protein; Provisional; Region: PHA02764 1110693009206 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 1110693009207 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1110693009208 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1110693009209 dimer interface [polypeptide binding]; other site 1110693009210 active site 1110693009211 fructoselysine 3-epimerase; Provisional; Region: PRK09856 1110693009212 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1110693009213 AP (apurinic/apyrimidinic) site pocket; other site 1110693009214 DNA interaction; other site 1110693009215 Metal-binding active site; metal-binding site 1110693009216 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1110693009217 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1110693009218 substrate binding site [chemical binding]; other site 1110693009219 ATP binding site [chemical binding]; other site 1110693009220 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1110693009221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693009222 DNA-binding site [nucleotide binding]; DNA binding site 1110693009223 UTRA domain; Region: UTRA; pfam07702 1110693009224 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1110693009225 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 1110693009226 Protein of unknown function; Region: YhfT; pfam10797 1110693009227 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 1110693009228 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1110693009229 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1110693009230 active site 1110693009231 substrate binding pocket [chemical binding]; other site 1110693009232 homodimer interaction site [polypeptide binding]; other site 1110693009233 putative mutase; Provisional; Region: PRK12383 1110693009234 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 1110693009235 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 1110693009236 dimer interface [polypeptide binding]; other site 1110693009237 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1110693009238 active site 1110693009239 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1110693009240 substrate binding site [chemical binding]; other site 1110693009241 catalytic residue [active] 1110693009242 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1110693009243 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1110693009244 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1110693009245 active site 1110693009246 HIGH motif; other site 1110693009247 dimer interface [polypeptide binding]; other site 1110693009248 KMSKS motif; other site 1110693009249 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1110693009250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693009251 motif II; other site 1110693009252 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1110693009253 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1110693009254 substrate binding site [chemical binding]; other site 1110693009255 hexamer interface [polypeptide binding]; other site 1110693009256 metal binding site [ion binding]; metal-binding site 1110693009257 DNA adenine methylase; Provisional; Region: PRK10904 1110693009258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1110693009259 cell division protein DamX; Validated; Region: PRK10905 1110693009260 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1110693009261 active site 1110693009262 dimer interface [polypeptide binding]; other site 1110693009263 metal binding site [ion binding]; metal-binding site 1110693009264 shikimate kinase; Reviewed; Region: aroK; PRK00131 1110693009265 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1110693009266 ADP binding site [chemical binding]; other site 1110693009267 magnesium binding site [ion binding]; other site 1110693009268 putative shikimate binding site; other site 1110693009269 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1110693009270 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1110693009271 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1110693009272 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1110693009273 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1110693009274 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1110693009275 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1110693009276 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1110693009277 Transglycosylase; Region: Transgly; pfam00912 1110693009278 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1110693009279 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1110693009280 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1110693009281 ADP-ribose binding site [chemical binding]; other site 1110693009282 dimer interface [polypeptide binding]; other site 1110693009283 active site 1110693009284 nudix motif; other site 1110693009285 metal binding site [ion binding]; metal-binding site 1110693009286 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1110693009287 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1110693009288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693009289 motif II; other site 1110693009290 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1110693009291 RNA binding surface [nucleotide binding]; other site 1110693009292 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1110693009293 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1110693009294 dimerization interface [polypeptide binding]; other site 1110693009295 domain crossover interface; other site 1110693009296 redox-dependent activation switch; other site 1110693009297 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1110693009298 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1110693009299 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1110693009300 active site 1110693009301 substrate-binding site [chemical binding]; other site 1110693009302 metal-binding site [ion binding] 1110693009303 ATP binding site [chemical binding]; other site 1110693009304 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1110693009305 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1110693009306 dimerization interface [polypeptide binding]; other site 1110693009307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693009308 dimer interface [polypeptide binding]; other site 1110693009309 phosphorylation site [posttranslational modification] 1110693009310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693009311 ATP binding site [chemical binding]; other site 1110693009312 G-X-G motif; other site 1110693009313 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1110693009314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693009315 active site 1110693009316 phosphorylation site [posttranslational modification] 1110693009317 intermolecular recognition site; other site 1110693009318 dimerization interface [polypeptide binding]; other site 1110693009319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693009320 DNA binding site [nucleotide binding] 1110693009321 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1110693009322 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1110693009323 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1110693009324 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1110693009325 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1110693009326 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1110693009327 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1110693009328 RNA binding site [nucleotide binding]; other site 1110693009329 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1110693009330 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1110693009331 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1110693009332 G1 box; other site 1110693009333 GTP/Mg2+ binding site [chemical binding]; other site 1110693009334 Switch I region; other site 1110693009335 G2 box; other site 1110693009336 G3 box; other site 1110693009337 Switch II region; other site 1110693009338 G4 box; other site 1110693009339 G5 box; other site 1110693009340 Nucleoside recognition; Region: Gate; pfam07670 1110693009341 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1110693009342 Nucleoside recognition; Region: Gate; pfam07670 1110693009343 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1110693009344 putative transposase; Provisional; Region: PRK09857 1110693009345 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1110693009346 carboxylesterase BioH; Provisional; Region: PRK10349 1110693009347 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1110693009348 DNA utilization protein GntX; Provisional; Region: PRK11595 1110693009349 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1110693009350 active site 1110693009351 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1110693009352 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1110693009353 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1110693009354 high-affinity gluconate transporter; Provisional; Region: PRK14984 1110693009355 gluconate transporter; Region: gntP; TIGR00791 1110693009356 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1110693009357 4-alpha-glucanotransferase; Region: malQ; TIGR00217 1110693009358 maltodextrin phosphorylase; Provisional; Region: PRK14985 1110693009359 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1110693009360 homodimer interface [polypeptide binding]; other site 1110693009361 active site pocket [active] 1110693009362 transcriptional regulator MalT; Provisional; Region: PRK04841 1110693009363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693009364 DNA binding residues [nucleotide binding] 1110693009365 dimerization interface [polypeptide binding]; other site 1110693009366 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1110693009367 RNA 3' phosphate cyclase domain - RNA phosphate cyclases are enzymes that catalyze the ATP-dependent conversion of 3'-phosphate at the end of RNA into 2', 3'-cyclic phosphodiester bond. The enzymes are conserved in eucaryotes; Region: RNA_Cyclase; cd00295 1110693009368 putative active site [active] 1110693009369 adenylation catalytic residue [active] 1110693009370 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1110693009371 hypothetical protein; Reviewed; Region: PRK09588 1110693009372 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1110693009373 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1110693009374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693009375 Walker A motif; other site 1110693009376 ATP binding site [chemical binding]; other site 1110693009377 Walker B motif; other site 1110693009378 arginine finger; other site 1110693009379 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1110693009380 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1110693009381 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1110693009382 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1110693009383 active site residue [active] 1110693009384 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1110693009385 glycogen phosphorylase; Provisional; Region: PRK14986 1110693009386 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1110693009387 homodimer interface [polypeptide binding]; other site 1110693009388 active site pocket [active] 1110693009389 glycogen synthase; Provisional; Region: glgA; PRK00654 1110693009390 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1110693009391 ADP-binding pocket [chemical binding]; other site 1110693009392 homodimer interface [polypeptide binding]; other site 1110693009393 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1110693009394 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1110693009395 ligand binding site; other site 1110693009396 oligomer interface; other site 1110693009397 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1110693009398 sulfate 1 binding site; other site 1110693009399 glycogen debranching enzyme; Provisional; Region: PRK03705 1110693009400 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1110693009401 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1110693009402 active site 1110693009403 catalytic site [active] 1110693009404 glycogen branching enzyme; Provisional; Region: PRK05402 1110693009405 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1110693009406 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1110693009407 active site 1110693009408 catalytic site [active] 1110693009409 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1110693009410 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1110693009411 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1110693009412 putative antibiotic transporter; Provisional; Region: PRK10739 1110693009413 low affinity gluconate transporter; Provisional; Region: PRK10472 1110693009414 gluconate transporter; Region: gntP; TIGR00791 1110693009415 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1110693009416 ATP-binding site [chemical binding]; other site 1110693009417 Gluconate-6-phosphate binding site [chemical binding]; other site 1110693009418 Shikimate kinase; Region: SKI; pfam01202 1110693009419 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1110693009420 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693009421 DNA binding site [nucleotide binding] 1110693009422 domain linker motif; other site 1110693009423 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1110693009424 putative ligand binding site [chemical binding]; other site 1110693009425 putative dimerization interface [polypeptide binding]; other site 1110693009426 Pirin-related protein [General function prediction only]; Region: COG1741 1110693009427 Pirin; Region: Pirin; pfam02678 1110693009428 putative oxidoreductase; Provisional; Region: PRK10206 1110693009429 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1110693009430 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1110693009431 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1110693009432 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1110693009433 hypothetical protein; Provisional; Region: PRK10350 1110693009434 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1110693009435 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1110693009436 putative active site [active] 1110693009437 catalytic site [active] 1110693009438 putative metal binding site [ion binding]; other site 1110693009439 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1110693009440 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1110693009441 Walker A/P-loop; other site 1110693009442 ATP binding site [chemical binding]; other site 1110693009443 Q-loop/lid; other site 1110693009444 ABC transporter signature motif; other site 1110693009445 Walker B; other site 1110693009446 D-loop; other site 1110693009447 H-loop/switch region; other site 1110693009448 TOBE domain; Region: TOBE_2; pfam08402 1110693009449 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1110693009450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693009451 dimer interface [polypeptide binding]; other site 1110693009452 conserved gate region; other site 1110693009453 putative PBP binding loops; other site 1110693009454 ABC-ATPase subunit interface; other site 1110693009455 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1110693009456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693009457 dimer interface [polypeptide binding]; other site 1110693009458 conserved gate region; other site 1110693009459 putative PBP binding loops; other site 1110693009460 ABC-ATPase subunit interface; other site 1110693009461 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1110693009462 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1110693009463 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1110693009464 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1110693009465 Walker A/P-loop; other site 1110693009466 ATP binding site [chemical binding]; other site 1110693009467 Q-loop/lid; other site 1110693009468 ABC transporter signature motif; other site 1110693009469 Walker B; other site 1110693009470 D-loop; other site 1110693009471 H-loop/switch region; other site 1110693009472 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1110693009473 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1110693009474 Walker A/P-loop; other site 1110693009475 ATP binding site [chemical binding]; other site 1110693009476 Q-loop/lid; other site 1110693009477 ABC transporter signature motif; other site 1110693009478 Walker B; other site 1110693009479 D-loop; other site 1110693009480 H-loop/switch region; other site 1110693009481 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1110693009482 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1110693009483 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1110693009484 TM-ABC transporter signature motif; other site 1110693009485 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1110693009486 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1110693009487 TM-ABC transporter signature motif; other site 1110693009488 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1110693009489 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1110693009490 dimerization interface [polypeptide binding]; other site 1110693009491 ligand binding site [chemical binding]; other site 1110693009492 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1110693009493 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1110693009494 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1110693009495 dimerization interface [polypeptide binding]; other site 1110693009496 ligand binding site [chemical binding]; other site 1110693009497 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1110693009498 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1110693009499 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1110693009500 DNA binding residues [nucleotide binding] 1110693009501 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1110693009502 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1110693009503 cell division protein FtsE; Provisional; Region: PRK10908 1110693009504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693009505 Walker A/P-loop; other site 1110693009506 ATP binding site [chemical binding]; other site 1110693009507 Q-loop/lid; other site 1110693009508 ABC transporter signature motif; other site 1110693009509 Walker B; other site 1110693009510 D-loop; other site 1110693009511 H-loop/switch region; other site 1110693009512 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1110693009513 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1110693009514 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1110693009515 P loop; other site 1110693009516 GTP binding site [chemical binding]; other site 1110693009517 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1110693009518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693009519 S-adenosylmethionine binding site [chemical binding]; other site 1110693009520 hypothetical protein; Provisional; Region: PRK10910 1110693009521 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1110693009522 Predicted membrane protein [Function unknown]; Region: COG3714 1110693009523 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1110693009524 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1110693009525 metal-binding site [ion binding] 1110693009526 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1110693009527 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1110693009528 CPxP motif; other site 1110693009529 hypothetical protein; Provisional; Region: PRK11212 1110693009530 hypothetical protein; Provisional; Region: PRK11615 1110693009531 major facilitator superfamily transporter; Provisional; Region: PRK05122 1110693009532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693009533 putative substrate translocation pore; other site 1110693009534 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1110693009535 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1110693009536 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1110693009537 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1110693009538 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1110693009539 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1110693009540 substrate binding site [chemical binding]; other site 1110693009541 nickel transporter permease NikB; Provisional; Region: PRK10352 1110693009542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693009543 dimer interface [polypeptide binding]; other site 1110693009544 conserved gate region; other site 1110693009545 putative PBP binding loops; other site 1110693009546 ABC-ATPase subunit interface; other site 1110693009547 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1110693009548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693009549 dimer interface [polypeptide binding]; other site 1110693009550 conserved gate region; other site 1110693009551 putative PBP binding loops; other site 1110693009552 ABC-ATPase subunit interface; other site 1110693009553 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 1110693009554 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693009555 Walker A/P-loop; other site 1110693009556 ATP binding site [chemical binding]; other site 1110693009557 Q-loop/lid; other site 1110693009558 ABC transporter signature motif; other site 1110693009559 Walker B; other site 1110693009560 D-loop; other site 1110693009561 H-loop/switch region; other site 1110693009562 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1110693009563 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 1110693009564 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693009565 Walker A/P-loop; other site 1110693009566 ATP binding site [chemical binding]; other site 1110693009567 Q-loop/lid; other site 1110693009568 ABC transporter signature motif; other site 1110693009569 Walker B; other site 1110693009570 D-loop; other site 1110693009571 H-loop/switch region; other site 1110693009572 nickel responsive regulator; Provisional; Region: PRK02967 1110693009573 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1110693009574 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1110693009575 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1110693009576 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1110693009577 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1110693009578 Walker A/P-loop; other site 1110693009579 ATP binding site [chemical binding]; other site 1110693009580 Q-loop/lid; other site 1110693009581 ABC transporter signature motif; other site 1110693009582 Walker B; other site 1110693009583 D-loop; other site 1110693009584 H-loop/switch region; other site 1110693009585 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1110693009586 Walker A/P-loop; other site 1110693009587 ATP binding site [chemical binding]; other site 1110693009588 Q-loop/lid; other site 1110693009589 ABC transporter signature motif; other site 1110693009590 Walker B; other site 1110693009591 D-loop; other site 1110693009592 H-loop/switch region; other site 1110693009593 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1110693009594 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1110693009595 HlyD family secretion protein; Region: HlyD; pfam00529 1110693009596 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693009597 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693009598 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 1110693009599 predicted protein (pseudogene) 1110693009600 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 1110693009601 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 1110693009602 Predicted flavoproteins [General function prediction only]; Region: COG2081 1110693009603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1110693009604 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1110693009605 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1110693009606 universal stress protein UspB; Provisional; Region: PRK04960 1110693009607 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1110693009608 Ligand Binding Site [chemical binding]; other site 1110693009609 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1110693009610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693009611 POT family; Region: PTR2; pfam00854 1110693009612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693009613 S-adenosylmethionine binding site [chemical binding]; other site 1110693009614 oligopeptidase A; Provisional; Region: PRK10911 1110693009615 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1110693009616 active site 1110693009617 Zn binding site [ion binding]; other site 1110693009618 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1110693009619 glutathione reductase; Validated; Region: PRK06116 1110693009620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1110693009621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693009622 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1110693009623 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1110693009624 dimerization interface [polypeptide binding]; other site 1110693009625 putative DNA binding site [nucleotide binding]; other site 1110693009626 putative Zn2+ binding site [ion binding]; other site 1110693009627 arsenical pump membrane protein; Provisional; Region: PRK15445 1110693009628 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1110693009629 transmembrane helices; other site 1110693009630 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1110693009631 ArsC family; Region: ArsC; pfam03960 1110693009632 catalytic residues [active] 1110693009633 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 1110693009634 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1110693009635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693009636 DNA binding residues [nucleotide binding] 1110693009637 dimerization interface [polypeptide binding]; other site 1110693009638 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 1110693009639 MgtC family; Region: MgtC; pfam02308 1110693009640 acid-resistance protein; Provisional; Region: hdeB; PRK11566 1110693009641 acid-resistance protein; Provisional; Region: PRK10208 1110693009642 acid-resistance membrane protein; Provisional; Region: PRK10209 1110693009643 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1110693009644 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1110693009645 pyruvate kinase; Provisional; Region: PRK05826 1110693009646 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1110693009647 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693009648 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693009649 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1110693009650 Protein export membrane protein; Region: SecD_SecF; cl14618 1110693009651 transcriptional regulator YdeO; Provisional; Region: PRK09940 1110693009652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693009653 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 1110693009654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693009655 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1110693009656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693009657 catalytic residue [active] 1110693009658 Haem-binding domain; Region: Haem_bd; pfam14376 1110693009659 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1110693009660 trehalase; Provisional; Region: treF; PRK13270 1110693009661 Trehalase; Region: Trehalase; pfam01204 1110693009662 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1110693009663 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693009664 DNA binding residues [nucleotide binding] 1110693009665 dimerization interface [polypeptide binding]; other site 1110693009666 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1110693009667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693009668 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1110693009669 putative effector binding pocket; other site 1110693009670 putative dimerization interface [polypeptide binding]; other site 1110693009671 inner membrane protein YhjD; Region: TIGR00766 1110693009672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693009673 metabolite-proton symporter; Region: 2A0106; TIGR00883 1110693009674 putative substrate translocation pore; other site 1110693009675 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1110693009676 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1110693009677 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1110693009678 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1110693009679 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1110693009680 substrate binding site [chemical binding]; other site 1110693009681 ATP binding site [chemical binding]; other site 1110693009682 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1110693009683 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1110693009684 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1110693009685 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1110693009686 putative diguanylate cyclase; Provisional; Region: PRK13561 1110693009687 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1110693009688 metal binding site [ion binding]; metal-binding site 1110693009689 active site 1110693009690 I-site; other site 1110693009691 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1110693009692 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1110693009693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1110693009694 binding surface 1110693009695 TPR motif; other site 1110693009696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1110693009697 binding surface 1110693009698 TPR motif; other site 1110693009699 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1110693009700 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1110693009701 cellulose synthase regulator protein; Provisional; Region: PRK11114 1110693009702 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1110693009703 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1110693009704 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1110693009705 DXD motif; other site 1110693009706 PilZ domain; Region: PilZ; pfam07238 1110693009707 cell division protein (chromosome partitioning ATPase) (pseudogene) 1110693009708 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1110693009709 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1110693009710 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1110693009711 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 1110693009712 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 1110693009713 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1110693009714 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1110693009715 serine transporter; Region: stp; TIGR00814 1110693009716 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1110693009717 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693009718 Walker A/P-loop; other site 1110693009719 ATP binding site [chemical binding]; other site 1110693009720 Q-loop/lid; other site 1110693009721 ABC transporter signature motif; other site 1110693009722 Walker B; other site 1110693009723 D-loop; other site 1110693009724 H-loop/switch region; other site 1110693009725 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1110693009726 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1110693009727 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693009728 Walker A/P-loop; other site 1110693009729 ATP binding site [chemical binding]; other site 1110693009730 Q-loop/lid; other site 1110693009731 ABC transporter signature motif; other site 1110693009732 Walker B; other site 1110693009733 D-loop; other site 1110693009734 H-loop/switch region; other site 1110693009735 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1110693009736 dipeptide transporter; Provisional; Region: PRK10913 1110693009737 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1110693009738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693009739 dimer interface [polypeptide binding]; other site 1110693009740 conserved gate region; other site 1110693009741 putative PBP binding loops; other site 1110693009742 ABC-ATPase subunit interface; other site 1110693009743 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1110693009744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693009745 dimer interface [polypeptide binding]; other site 1110693009746 conserved gate region; other site 1110693009747 putative PBP binding loops; other site 1110693009748 ABC-ATPase subunit interface; other site 1110693009749 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1110693009750 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1110693009751 peptide binding site [polypeptide binding]; other site 1110693009752 phosphoethanolamine transferase; Provisional; Region: PRK11560 1110693009753 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1110693009754 Sulfatase; Region: Sulfatase; pfam00884 1110693009755 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1110693009756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693009757 putative substrate translocation pore; other site 1110693009758 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1110693009759 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 1110693009760 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1110693009761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1110693009762 Coenzyme A binding pocket [chemical binding]; other site 1110693009763 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1110693009764 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1110693009765 molybdopterin cofactor binding site [chemical binding]; other site 1110693009766 substrate binding site [chemical binding]; other site 1110693009767 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1110693009768 molybdopterin cofactor binding site; other site 1110693009769 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1110693009770 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1110693009771 ligand binding site [chemical binding]; other site 1110693009772 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1110693009773 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1110693009774 dimerization interface [polypeptide binding]; other site 1110693009775 ligand binding site [chemical binding]; other site 1110693009776 NADP binding site [chemical binding]; other site 1110693009777 catalytic site [active] 1110693009778 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1110693009779 Predicted transcriptional regulator [Transcription]; Region: COG2944 1110693009780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1110693009781 non-specific DNA binding site [nucleotide binding]; other site 1110693009782 salt bridge; other site 1110693009783 sequence-specific DNA binding site [nucleotide binding]; other site 1110693009784 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1110693009785 DNA-binding site [nucleotide binding]; DNA binding site 1110693009786 RNA-binding motif; other site 1110693009787 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1110693009788 DALR anticodon binding domain; Region: DALR_1; pfam05746 1110693009789 anticodon binding site; other site 1110693009790 tRNA binding surface [nucleotide binding]; other site 1110693009791 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1110693009792 dimer interface [polypeptide binding]; other site 1110693009793 motif 1; other site 1110693009794 active site 1110693009795 motif 2; other site 1110693009796 motif 3; other site 1110693009797 YsaB-like lipoprotein; Region: YsaB; pfam13983 1110693009798 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1110693009799 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1110693009800 hypothetical protein; Provisional; Region: PRK11383 1110693009801 yiaA/B two helix domain; Region: YiaAB; pfam05360 1110693009802 yiaA/B two helix domain; Region: YiaAB; pfam05360 1110693009803 hypothetical protein; Provisional; Region: PRK11403 1110693009804 yiaA/B two helix domain; Region: YiaAB; pfam05360 1110693009805 xylulokinase; Provisional; Region: PRK15027 1110693009806 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1110693009807 N- and C-terminal domain interface [polypeptide binding]; other site 1110693009808 active site 1110693009809 MgATP binding site [chemical binding]; other site 1110693009810 catalytic site [active] 1110693009811 metal binding site [ion binding]; metal-binding site 1110693009812 xylulose binding site [chemical binding]; other site 1110693009813 homodimer interface [polypeptide binding]; other site 1110693009814 xylose isomerase; Provisional; Region: PRK05474 1110693009815 xylose isomerase; Region: xylose_isom_A; TIGR02630 1110693009816 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1110693009817 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1110693009818 putative ligand binding site [chemical binding]; other site 1110693009819 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1110693009820 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1110693009821 Walker A/P-loop; other site 1110693009822 ATP binding site [chemical binding]; other site 1110693009823 Q-loop/lid; other site 1110693009824 ABC transporter signature motif; other site 1110693009825 Walker B; other site 1110693009826 D-loop; other site 1110693009827 H-loop/switch region; other site 1110693009828 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1110693009829 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1110693009830 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1110693009831 TM-ABC transporter signature motif; other site 1110693009832 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1110693009833 putative dimerization interface [polypeptide binding]; other site 1110693009834 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1110693009835 putative ligand binding site [chemical binding]; other site 1110693009836 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693009837 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1110693009838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693009839 hypothetical protein; Provisional; Region: PRK10356 1110693009840 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1110693009841 alpha-amylase; Reviewed; Region: malS; PRK09505 1110693009842 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1110693009843 active site 1110693009844 catalytic site [active] 1110693009845 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1110693009846 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1110693009847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693009848 homodimer interface [polypeptide binding]; other site 1110693009849 catalytic residue [active] 1110693009850 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1110693009851 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1110693009852 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1110693009853 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1110693009854 Bacterial transcriptional regulator; Region: IclR; pfam01614 1110693009855 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1110693009856 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 1110693009857 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 1110693009858 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 1110693009859 DctM-like transporters; Region: DctM; pfam06808 1110693009860 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1110693009861 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1110693009862 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1110693009863 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1110693009864 putative N- and C-terminal domain interface [polypeptide binding]; other site 1110693009865 putative active site [active] 1110693009866 MgATP binding site [chemical binding]; other site 1110693009867 catalytic site [active] 1110693009868 metal binding site [ion binding]; metal-binding site 1110693009869 putative xylulose binding site [chemical binding]; other site 1110693009870 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1110693009871 active site 1110693009872 dimer interface [polypeptide binding]; other site 1110693009873 magnesium binding site [ion binding]; other site 1110693009874 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1110693009875 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1110693009876 AP (apurinic/apyrimidinic) site pocket; other site 1110693009877 DNA interaction; other site 1110693009878 Metal-binding active site; metal-binding site 1110693009879 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1110693009880 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1110693009881 intersubunit interface [polypeptide binding]; other site 1110693009882 active site 1110693009883 Zn2+ binding site [ion binding]; other site 1110693009884 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1110693009885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1110693009886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693009887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1110693009888 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1110693009889 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693009890 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693009891 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1110693009892 FlxA-like protein; Region: FlxA; pfam14282 1110693009893 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1110693009894 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1110693009895 NAD(P) binding site [chemical binding]; other site 1110693009896 catalytic residues [active] 1110693009897 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1110693009898 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1110693009899 dimer interface [polypeptide binding]; other site 1110693009900 active site 1110693009901 metal binding site [ion binding]; metal-binding site 1110693009902 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1110693009903 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1110693009904 G1 box; other site 1110693009905 putative GEF interaction site [polypeptide binding]; other site 1110693009906 GTP/Mg2+ binding site [chemical binding]; other site 1110693009907 Switch I region; other site 1110693009908 G2 box; other site 1110693009909 G3 box; other site 1110693009910 Switch II region; other site 1110693009911 G4 box; other site 1110693009912 G5 box; other site 1110693009913 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1110693009914 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1110693009915 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1110693009916 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1110693009917 selenocysteine synthase; Provisional; Region: PRK04311 1110693009918 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1110693009919 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1110693009920 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1110693009921 catalytic residue [active] 1110693009922 putative glutathione S-transferase; Provisional; Region: PRK10357 1110693009923 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1110693009924 putative C-terminal domain interface [polypeptide binding]; other site 1110693009925 putative GSH binding site (G-site) [chemical binding]; other site 1110693009926 putative dimer interface [polypeptide binding]; other site 1110693009927 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1110693009928 dimer interface [polypeptide binding]; other site 1110693009929 N-terminal domain interface [polypeptide binding]; other site 1110693009930 putative substrate binding pocket (H-site) [chemical binding]; other site 1110693009931 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1110693009932 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693009933 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693009934 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1110693009935 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1110693009936 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1110693009937 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1110693009938 active site 1110693009939 P-loop; other site 1110693009940 phosphorylation site [posttranslational modification] 1110693009941 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1110693009942 active site 1110693009943 phosphorylation site [posttranslational modification] 1110693009944 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1110693009945 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1110693009946 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1110693009947 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1110693009948 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1110693009949 hypothetical protein; Provisional; Region: PRK11020 1110693009950 L-lactate permease; Provisional; Region: PRK10420 1110693009951 glycolate transporter; Provisional; Region: PRK09695 1110693009952 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1110693009953 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693009954 DNA-binding site [nucleotide binding]; DNA binding site 1110693009955 FCD domain; Region: FCD; pfam07729 1110693009956 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1110693009957 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1110693009958 phosphate binding site [ion binding]; other site 1110693009959 putative rRNA methylase; Provisional; Region: PRK10358 1110693009960 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1110693009961 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1110693009962 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1110693009963 trimer interface [polypeptide binding]; other site 1110693009964 active site 1110693009965 substrate binding site [chemical binding]; other site 1110693009966 CoA binding site [chemical binding]; other site 1110693009967 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1110693009968 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1110693009969 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1110693009970 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1110693009971 SecA binding site; other site 1110693009972 Preprotein binding site; other site 1110693009973 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1110693009974 GSH binding site [chemical binding]; other site 1110693009975 catalytic residues [active] 1110693009976 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1110693009977 active site residue [active] 1110693009978 phosphoglyceromutase; Provisional; Region: PRK05434 1110693009979 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1110693009980 AmiB activator; Provisional; Region: PRK11637 1110693009981 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1110693009982 Peptidase family M23; Region: Peptidase_M23; pfam01551 1110693009983 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1110693009984 NodB motif; other site 1110693009985 putative active site [active] 1110693009986 putative catalytic site [active] 1110693009987 Zn binding site [ion binding]; other site 1110693009988 putative glycosyl transferase; Provisional; Region: PRK10073 1110693009989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1110693009990 active site 1110693009991 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1110693009992 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1110693009993 NAD(P) binding site [chemical binding]; other site 1110693009994 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1110693009995 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1110693009996 substrate-cofactor binding pocket; other site 1110693009997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693009998 catalytic residue [active] 1110693009999 hypothetical protein; Provisional; Region: PRK11346 1110693010000 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1110693010001 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1110693010002 NADP binding site [chemical binding]; other site 1110693010003 homopentamer interface [polypeptide binding]; other site 1110693010004 substrate binding site [chemical binding]; other site 1110693010005 active site 1110693010006 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1110693010007 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1110693010008 putative active site [active] 1110693010009 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1110693010010 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1110693010011 putative active site [active] 1110693010012 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1110693010013 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1110693010014 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1110693010015 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1110693010016 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1110693010017 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10359 1110693010018 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1110693010019 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1110693010020 Ligand binding site; other site 1110693010021 metal-binding site 1110693010022 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1110693010023 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 1110693010024 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1110693010025 putative ADP-binding pocket [chemical binding]; other site 1110693010026 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1110693010027 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1110693010028 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1110693010029 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1110693010030 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1110693010031 putative active site [active] 1110693010032 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1110693010033 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1110693010034 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1110693010035 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1110693010036 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1110693010037 active site 1110693010038 (T/H)XGH motif; other site 1110693010039 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1110693010040 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1110693010041 DNA binding site [nucleotide binding] 1110693010042 catalytic residue [active] 1110693010043 H2TH interface [polypeptide binding]; other site 1110693010044 putative catalytic residues [active] 1110693010045 turnover-facilitating residue; other site 1110693010046 intercalation triad [nucleotide binding]; other site 1110693010047 8OG recognition residue [nucleotide binding]; other site 1110693010048 putative reading head residues; other site 1110693010049 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1110693010050 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1110693010051 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1110693010052 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1110693010053 hypothetical protein; Reviewed; Region: PRK00024 1110693010054 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1110693010055 MPN+ (JAMM) motif; other site 1110693010056 Zinc-binding site [ion binding]; other site 1110693010057 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1110693010058 Flavoprotein; Region: Flavoprotein; pfam02441 1110693010059 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1110693010060 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1110693010061 trimer interface [polypeptide binding]; other site 1110693010062 active site 1110693010063 division inhibitor protein; Provisional; Region: slmA; PRK09480 1110693010064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1110693010065 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1110693010066 active site 1110693010067 ribonuclease PH (pseudogene) 1110693010068 hypothetical protein; Provisional; Region: PRK11820 1110693010069 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1110693010070 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1110693010071 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 1110693010072 BRO family, N-terminal domain; Region: Bro-N; pfam02498 1110693010073 Predicted membrane protein [Function unknown]; Region: COG2860 1110693010074 UPF0126 domain; Region: UPF0126; pfam03458 1110693010075 UPF0126 domain; Region: UPF0126; pfam03458 1110693010076 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1110693010077 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1110693010078 nucleotide binding pocket [chemical binding]; other site 1110693010079 K-X-D-G motif; other site 1110693010080 catalytic site [active] 1110693010081 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1110693010082 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1110693010083 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1110693010084 catalytic site [active] 1110693010085 G-X2-G-X-G-K; other site 1110693010086 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1110693010087 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1110693010088 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1110693010089 Zn2+ binding site [ion binding]; other site 1110693010090 Mg2+ binding site [ion binding]; other site 1110693010091 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1110693010092 synthetase active site [active] 1110693010093 NTP binding site [chemical binding]; other site 1110693010094 metal binding site [ion binding]; metal-binding site 1110693010095 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1110693010096 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1110693010097 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1110693010098 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1110693010099 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1110693010100 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1110693010101 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1110693010102 generic binding surface II; other site 1110693010103 ssDNA binding site; other site 1110693010104 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1110693010105 ATP binding site [chemical binding]; other site 1110693010106 putative Mg++ binding site [ion binding]; other site 1110693010107 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1110693010108 nucleotide binding region [chemical binding]; other site 1110693010109 ATP-binding site [chemical binding]; other site 1110693010110 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1110693010111 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1110693010112 AsmA family; Region: AsmA; pfam05170 1110693010113 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1110693010114 putative alpha-glucosidase; Provisional; Region: PRK10658 1110693010115 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1110693010116 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1110693010117 active site 1110693010118 homotrimer interface [polypeptide binding]; other site 1110693010119 catalytic site [active] 1110693010120 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1110693010121 putative transporter; Provisional; Region: PRK11462 1110693010122 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1110693010123 sugar efflux transporter; Region: 2A0120; TIGR00899 1110693010124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693010125 putative substrate translocation pore; other site 1110693010126 EamA-like transporter family; Region: EamA; pfam00892 1110693010127 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1110693010128 EamA-like transporter family; Region: EamA; pfam00892 1110693010129 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1110693010130 lipoprotein, YaeC family; Region: TIGR00363 1110693010131 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1110693010132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693010133 putative substrate translocation pore; other site 1110693010134 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1110693010135 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1110693010136 cryptic adenine deaminase; Provisional; Region: PRK10027 1110693010137 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1110693010138 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1110693010139 active site 1110693010140 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1110693010141 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1110693010142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693010143 putative substrate translocation pore; other site 1110693010144 regulatory protein UhpC; Provisional; Region: PRK11663 1110693010145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693010146 putative substrate translocation pore; other site 1110693010147 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1110693010148 MASE1; Region: MASE1; pfam05231 1110693010149 Histidine kinase; Region: HisKA_3; pfam07730 1110693010150 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1110693010151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693010152 active site 1110693010153 phosphorylation site [posttranslational modification] 1110693010154 intermolecular recognition site; other site 1110693010155 dimerization interface [polypeptide binding]; other site 1110693010156 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693010157 DNA binding residues [nucleotide binding] 1110693010158 dimerization interface [polypeptide binding]; other site 1110693010159 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1110693010160 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1110693010161 putative valine binding site [chemical binding]; other site 1110693010162 dimer interface [polypeptide binding]; other site 1110693010163 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1110693010164 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1110693010165 PYR/PP interface [polypeptide binding]; other site 1110693010166 dimer interface [polypeptide binding]; other site 1110693010167 TPP binding site [chemical binding]; other site 1110693010168 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1110693010169 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1110693010170 TPP-binding site [chemical binding]; other site 1110693010171 dimer interface [polypeptide binding]; other site 1110693010172 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1110693010173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693010174 putative substrate translocation pore; other site 1110693010175 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1110693010176 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1110693010177 Predicted membrane protein [Function unknown]; Region: COG2149 1110693010178 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1110693010179 Sulfatase; Region: Sulfatase; pfam00884 1110693010180 putative transporter; Provisional; Region: PRK10484 1110693010181 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 1110693010182 Na binding site [ion binding]; other site 1110693010183 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1110693010184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693010185 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1110693010186 predicted protein (pseudogene) 1110693010187 predicted 6-phospho-beta-glucosidase (pseudogene) 1110693010188 PTS system arbutin-specific transporter subunit IIB; Provisional; Region: PRK09702 1110693010189 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1110693010190 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1110693010191 active site turn [active] 1110693010192 phosphorylation site [posttranslational modification] 1110693010193 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1110693010194 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1110693010195 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1110693010196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693010197 DNA-binding site [nucleotide binding]; DNA binding site 1110693010198 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1110693010199 putative transporter; Validated; Region: PRK03818 1110693010200 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1110693010201 TrkA-C domain; Region: TrkA_C; pfam02080 1110693010202 TrkA-C domain; Region: TrkA_C; pfam02080 1110693010203 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1110693010204 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1110693010205 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1110693010206 putative dimer interface [polypeptide binding]; other site 1110693010207 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1110693010208 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1110693010209 putative dimer interface [polypeptide binding]; other site 1110693010210 hypothetical protein; Provisional; Region: PRK11616 1110693010211 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1110693010212 putative oxidoreductase; Provisional; Region: PRK11445 1110693010213 hypothetical protein; Provisional; Region: PRK07236 1110693010214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693010215 D-galactonate transporter; Region: 2A0114; TIGR00893 1110693010216 putative substrate translocation pore; other site 1110693010217 galactonate dehydratase; Provisional; Region: PRK14017 1110693010218 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1110693010219 putative active site pocket [active] 1110693010220 putative metal binding site [ion binding]; other site 1110693010221 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1110693010222 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1110693010223 active site 1110693010224 intersubunit interface [polypeptide binding]; other site 1110693010225 catalytic residue [active] 1110693010226 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1110693010227 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1110693010228 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1110693010229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693010230 DNA-binding site [nucleotide binding]; DNA binding site 1110693010231 FCD domain; Region: FCD; pfam07729 1110693010232 hypothetical protein; Provisional; Region: PRK10215 1110693010233 sugar phosphate phosphatase; Provisional; Region: PRK10513 1110693010234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693010235 active site 1110693010236 motif I; other site 1110693010237 motif II; other site 1110693010238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693010239 hypothetical protein; Provisional; Region: PRK11426 1110693010240 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1110693010241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693010242 Mg2+ binding site [ion binding]; other site 1110693010243 G-X-G motif; other site 1110693010244 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1110693010245 anchoring element; other site 1110693010246 dimer interface [polypeptide binding]; other site 1110693010247 ATP binding site [chemical binding]; other site 1110693010248 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1110693010249 active site 1110693010250 putative metal-binding site [ion binding]; other site 1110693010251 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1110693010252 recF protein; Region: recf; TIGR00611 1110693010253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693010254 Walker A/P-loop; other site 1110693010255 ATP binding site [chemical binding]; other site 1110693010256 Q-loop/lid; other site 1110693010257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693010258 ABC transporter signature motif; other site 1110693010259 Walker B; other site 1110693010260 D-loop; other site 1110693010261 H-loop/switch region; other site 1110693010262 DNA polymerase III subunit beta; Validated; Region: PRK05643 1110693010263 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1110693010264 putative DNA binding surface [nucleotide binding]; other site 1110693010265 dimer interface [polypeptide binding]; other site 1110693010266 beta-clamp/clamp loader binding surface; other site 1110693010267 beta-clamp/translesion DNA polymerase binding surface; other site 1110693010268 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1110693010269 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1110693010270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693010271 Walker A motif; other site 1110693010272 ATP binding site [chemical binding]; other site 1110693010273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1110693010274 Walker B motif; other site 1110693010275 arginine finger; other site 1110693010276 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1110693010277 DnaA box-binding interface [nucleotide binding]; other site 1110693010278 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1110693010279 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1110693010280 hypothetical protein; Validated; Region: PRK00041 1110693010281 membrane protein insertase; Provisional; Region: PRK01318 1110693010282 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1110693010283 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1110693010284 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1110693010285 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1110693010286 G1 box; other site 1110693010287 GTP/Mg2+ binding site [chemical binding]; other site 1110693010288 Switch I region; other site 1110693010289 G2 box; other site 1110693010290 Switch II region; other site 1110693010291 G3 box; other site 1110693010292 G4 box; other site 1110693010293 G5 box; other site 1110693010294 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1110693010295 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 1110693010296 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 1110693010297 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1110693010298 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1110693010299 catalytic residue [active] 1110693010300 tryptophan permease TnaB; Provisional; Region: PRK09664 1110693010301 aromatic amino acid transport protein; Region: araaP; TIGR00837 1110693010302 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1110693010303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693010304 putative substrate translocation pore; other site 1110693010305 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1110693010306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693010307 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1110693010308 substrate binding pocket [chemical binding]; other site 1110693010309 dimerization interface [polypeptide binding]; other site 1110693010310 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1110693010311 Predicted flavoprotein [General function prediction only]; Region: COG0431 1110693010312 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1110693010313 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1110693010314 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1110693010315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693010316 active site 1110693010317 motif I; other site 1110693010318 motif II; other site 1110693010319 putative inner membrane protein; Provisional; Region: PRK09823 1110693010320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 1110693010321 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1110693010322 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1110693010323 active site 1110693010324 trimer interface [polypeptide binding]; other site 1110693010325 allosteric site; other site 1110693010326 active site lid [active] 1110693010327 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 1110693010328 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1110693010329 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1110693010330 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1110693010331 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1110693010332 trimer interface; other site 1110693010333 sugar binding site [chemical binding]; other site 1110693010334 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1110693010335 beta-galactosidase; Region: BGL; TIGR03356 1110693010336 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 1110693010337 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1110693010338 active site turn [active] 1110693010339 phosphorylation site [posttranslational modification] 1110693010340 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1110693010341 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1110693010342 HPr interaction site; other site 1110693010343 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1110693010344 active site 1110693010345 phosphorylation site [posttranslational modification] 1110693010346 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1110693010347 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1110693010348 PRD domain; Region: PRD; pfam00874 1110693010349 PRD domain; Region: PRD; pfam00874 1110693010350 transcriptional regulator PhoU; Provisional; Region: PRK11115 1110693010351 PhoU domain; Region: PhoU; pfam01895 1110693010352 PhoU domain; Region: PhoU; pfam01895 1110693010353 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1110693010354 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1110693010355 Walker A/P-loop; other site 1110693010356 ATP binding site [chemical binding]; other site 1110693010357 Q-loop/lid; other site 1110693010358 ABC transporter signature motif; other site 1110693010359 Walker B; other site 1110693010360 D-loop; other site 1110693010361 H-loop/switch region; other site 1110693010362 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1110693010363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693010364 dimer interface [polypeptide binding]; other site 1110693010365 conserved gate region; other site 1110693010366 putative PBP binding loops; other site 1110693010367 ABC-ATPase subunit interface; other site 1110693010368 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1110693010369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693010370 dimer interface [polypeptide binding]; other site 1110693010371 conserved gate region; other site 1110693010372 putative PBP binding loops; other site 1110693010373 ABC-ATPase subunit interface; other site 1110693010374 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693010375 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1110693010376 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1110693010377 glutaminase active site [active] 1110693010378 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1110693010379 dimer interface [polypeptide binding]; other site 1110693010380 active site 1110693010381 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1110693010382 dimer interface [polypeptide binding]; other site 1110693010383 active site 1110693010384 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1110693010385 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1110693010386 Substrate binding site; other site 1110693010387 Mg++ binding site; other site 1110693010388 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1110693010389 active site 1110693010390 substrate binding site [chemical binding]; other site 1110693010391 CoA binding site [chemical binding]; other site 1110693010392 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1110693010393 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1110693010394 gamma subunit interface [polypeptide binding]; other site 1110693010395 epsilon subunit interface [polypeptide binding]; other site 1110693010396 LBP interface [polypeptide binding]; other site 1110693010397 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1110693010398 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1110693010399 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1110693010400 alpha subunit interaction interface [polypeptide binding]; other site 1110693010401 Walker A motif; other site 1110693010402 ATP binding site [chemical binding]; other site 1110693010403 Walker B motif; other site 1110693010404 inhibitor binding site; inhibition site 1110693010405 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1110693010406 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1110693010407 core domain interface [polypeptide binding]; other site 1110693010408 delta subunit interface [polypeptide binding]; other site 1110693010409 epsilon subunit interface [polypeptide binding]; other site 1110693010410 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1110693010411 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1110693010412 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1110693010413 beta subunit interaction interface [polypeptide binding]; other site 1110693010414 Walker A motif; other site 1110693010415 ATP binding site [chemical binding]; other site 1110693010416 Walker B motif; other site 1110693010417 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1110693010418 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1110693010419 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1110693010420 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1110693010421 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1110693010422 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1110693010423 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1110693010424 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1110693010425 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1110693010426 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1110693010427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693010428 S-adenosylmethionine binding site [chemical binding]; other site 1110693010429 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1110693010430 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1110693010431 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1110693010432 FMN-binding protein MioC; Provisional; Region: PRK09004 1110693010433 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1110693010434 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1110693010435 putative DNA binding site [nucleotide binding]; other site 1110693010436 putative Zn2+ binding site [ion binding]; other site 1110693010437 AsnC family; Region: AsnC_trans_reg; pfam01037 1110693010438 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1110693010439 dimer interface [polypeptide binding]; other site 1110693010440 active site 1110693010441 hypothetical protein; Provisional; Region: yieM; PRK10997 1110693010442 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1110693010443 metal ion-dependent adhesion site (MIDAS); other site 1110693010444 regulatory ATPase RavA; Provisional; Region: PRK13531 1110693010445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693010446 Walker A motif; other site 1110693010447 ATP binding site [chemical binding]; other site 1110693010448 Walker B motif; other site 1110693010449 arginine finger; other site 1110693010450 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1110693010451 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1110693010452 potassium uptake protein; Region: kup; TIGR00794 1110693010453 D-ribose pyranase; Provisional; Region: PRK11797 1110693010454 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1110693010455 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1110693010456 Walker A/P-loop; other site 1110693010457 ATP binding site [chemical binding]; other site 1110693010458 Q-loop/lid; other site 1110693010459 ABC transporter signature motif; other site 1110693010460 Walker B; other site 1110693010461 D-loop; other site 1110693010462 H-loop/switch region; other site 1110693010463 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1110693010464 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1110693010465 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1110693010466 TM-ABC transporter signature motif; other site 1110693010467 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1110693010468 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1110693010469 ligand binding site [chemical binding]; other site 1110693010470 dimerization interface [polypeptide binding]; other site 1110693010471 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1110693010472 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1110693010473 substrate binding site [chemical binding]; other site 1110693010474 dimer interface [polypeptide binding]; other site 1110693010475 ATP binding site [chemical binding]; other site 1110693010476 transcriptional repressor RbsR; Provisional; Region: PRK10423 1110693010477 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693010478 DNA binding site [nucleotide binding] 1110693010479 domain linker motif; other site 1110693010480 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1110693010481 dimerization interface [polypeptide binding]; other site 1110693010482 ligand binding site [chemical binding]; other site 1110693010483 putative transporter; Provisional; Region: PRK10504 1110693010484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693010485 putative substrate translocation pore; other site 1110693010486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693010487 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1110693010488 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693010489 DNA-binding site [nucleotide binding]; DNA binding site 1110693010490 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1110693010491 transcriptional regulator HdfR; Provisional; Region: PRK03601 1110693010492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693010493 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1110693010494 dimerization interface [polypeptide binding]; other site 1110693010495 hypothetical protein; Provisional; Region: PRK11027 1110693010496 putative ATP-dependent protease; Provisional; Region: PRK09862 1110693010497 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1110693010498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693010499 Walker A motif; other site 1110693010500 ATP binding site [chemical binding]; other site 1110693010501 Walker B motif; other site 1110693010502 arginine finger; other site 1110693010503 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1110693010504 ilvG operon leader peptide; Provisional; Region: PRK10424 1110693010505 acetolactate synthase II, large subunit, N-ter fragment (pseudogene) 1110693010506 large subunit of acetolactate synthase II (pseudogene) 1110693010507 acetolactate synthase II, large subunit, C-ter fragment (pseudogene) 1110693010508 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1110693010509 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1110693010510 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1110693010511 homodimer interface [polypeptide binding]; other site 1110693010512 substrate-cofactor binding pocket; other site 1110693010513 catalytic residue [active] 1110693010514 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1110693010515 threonine dehydratase; Reviewed; Region: PRK09224 1110693010516 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1110693010517 tetramer interface [polypeptide binding]; other site 1110693010518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693010519 catalytic residue [active] 1110693010520 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1110693010521 putative Ile/Val binding site [chemical binding]; other site 1110693010522 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1110693010523 putative Ile/Val binding site [chemical binding]; other site 1110693010524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693010525 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1110693010526 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1110693010527 putative dimerization interface [polypeptide binding]; other site 1110693010528 ketol-acid reductoisomerase; Validated; Region: PRK05225 1110693010529 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1110693010530 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1110693010531 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1110693010532 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1110693010533 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1110693010534 PemK-like protein; Region: PemK; cl00995 1110693010535 conserved protein (pseudogene) 1110693010536 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1110693010537 Part of AAA domain; Region: AAA_19; pfam13245 1110693010538 Family description; Region: UvrD_C_2; pfam13538 1110693010539 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1110693010540 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1110693010541 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1110693010542 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1110693010543 ATP binding site [chemical binding]; other site 1110693010544 Mg++ binding site [ion binding]; other site 1110693010545 motif III; other site 1110693010546 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1110693010547 nucleotide binding region [chemical binding]; other site 1110693010548 ATP-binding site [chemical binding]; other site 1110693010549 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1110693010550 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1110693010551 catalytic residues [active] 1110693010552 putative rho operon leader peptide; Provisional; Region: PRK09979 1110693010553 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1110693010554 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1110693010555 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1110693010556 RNA binding site [nucleotide binding]; other site 1110693010557 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1110693010558 multimer interface [polypeptide binding]; other site 1110693010559 Walker A motif; other site 1110693010560 ATP binding site [chemical binding]; other site 1110693010561 Walker B motif; other site 1110693010562 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1110693010563 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1110693010564 Mg++ binding site [ion binding]; other site 1110693010565 putative catalytic motif [active] 1110693010566 substrate binding site [chemical binding]; other site 1110693010567 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1110693010568 Chain length determinant protein; Region: Wzz; pfam02706 1110693010569 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1110693010570 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1110693010571 active site 1110693010572 homodimer interface [polypeptide binding]; other site 1110693010573 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1110693010574 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1110693010575 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1110693010576 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1110693010577 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1110693010578 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1110693010579 NAD binding site [chemical binding]; other site 1110693010580 substrate binding site [chemical binding]; other site 1110693010581 homodimer interface [polypeptide binding]; other site 1110693010582 active site 1110693010583 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1110693010584 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1110693010585 substrate binding site; other site 1110693010586 tetramer interface; other site 1110693010587 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1110693010588 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1110693010589 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1110693010590 inhibitor-cofactor binding pocket; inhibition site 1110693010591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693010592 catalytic residue [active] 1110693010593 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1110693010594 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1110693010595 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1110693010596 putative common antigen polymerase; Provisional; Region: PRK02975 1110693010597 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1110693010598 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1110693010599 putative transport protein YifK; Provisional; Region: PRK10746 1110693010600 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1110693010601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693010602 FeS/SAM binding site; other site 1110693010603 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1110693010604 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1110693010605 Sulfatase; Region: Sulfatase; pfam00884 1110693010606 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1110693010607 HemY protein N-terminus; Region: HemY_N; pfam07219 1110693010608 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1110693010609 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1110693010610 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1110693010611 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1110693010612 active site 1110693010613 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1110693010614 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1110693010615 domain interfaces; other site 1110693010616 active site 1110693010617 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1110693010618 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1110693010619 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1110693010620 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1110693010621 putative iron binding site [ion binding]; other site 1110693010622 hypothetical protein; Provisional; Region: PRK09807 1110693010623 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1110693010624 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1110693010625 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1110693010626 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1110693010627 hypothetical protein; Provisional; Region: PRK10963 1110693010628 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1110693010629 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1110693010630 active site 1110693010631 DNA binding site [nucleotide binding] 1110693010632 Int/Topo IB signature motif; other site 1110693010633 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1110693010634 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693010635 motif II; other site 1110693010636 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1110693010637 Part of AAA domain; Region: AAA_19; pfam13245 1110693010638 Family description; Region: UvrD_C_2; pfam13538 1110693010639 Predicted periplasmic protein [Function unknown]; Region: COG3698 1110693010640 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1110693010641 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1110693010642 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1110693010643 Cl binding site [ion binding]; other site 1110693010644 oligomer interface [polypeptide binding]; other site 1110693010645 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1110693010646 hypothetical protein; Provisional; Region: PRK11371 1110693010647 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1110693010648 EamA-like transporter family; Region: EamA; cl17759 1110693010649 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1110693010650 CoenzymeA binding site [chemical binding]; other site 1110693010651 subunit interaction site [polypeptide binding]; other site 1110693010652 PHB binding site; other site 1110693010653 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1110693010654 dimerization interface [polypeptide binding]; other site 1110693010655 substrate binding site [chemical binding]; other site 1110693010656 active site 1110693010657 calcium binding site [ion binding]; other site 1110693010658 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1110693010659 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1110693010660 ATP binding site [chemical binding]; other site 1110693010661 putative Mg++ binding site [ion binding]; other site 1110693010662 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1110693010663 nucleotide binding region [chemical binding]; other site 1110693010664 ATP-binding site [chemical binding]; other site 1110693010665 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1110693010666 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1110693010667 threonine efflux system; Provisional; Region: PRK10229 1110693010668 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1110693010669 lysophospholipase L2; Provisional; Region: PRK10749 1110693010670 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1110693010671 putative hydrolase; Provisional; Region: PRK10976 1110693010672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693010673 active site 1110693010674 motif I; other site 1110693010675 motif II; other site 1110693010676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693010677 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1110693010678 EamA-like transporter family; Region: EamA; pfam00892 1110693010679 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1110693010680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693010681 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1110693010682 putative dimerization interface [polypeptide binding]; other site 1110693010683 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1110693010684 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1110693010685 THF binding site; other site 1110693010686 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1110693010687 substrate binding site [chemical binding]; other site 1110693010688 THF binding site; other site 1110693010689 zinc-binding site [ion binding]; other site 1110693010690 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1110693010691 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1110693010692 uridine phosphorylase; Provisional; Region: PRK11178 1110693010693 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1110693010694 DNA recombination protein RmuC; Provisional; Region: PRK10361 1110693010695 RmuC family; Region: RmuC; pfam02646 1110693010696 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1110693010697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693010698 S-adenosylmethionine binding site [chemical binding]; other site 1110693010699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1110693010700 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1110693010701 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1110693010702 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1110693010703 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1110693010704 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1110693010705 sec-independent translocase; Provisional; Region: PRK01770 1110693010706 sec-independent translocase; Provisional; Region: tatB; PRK00404 1110693010707 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1110693010708 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1110693010709 active site 1110693010710 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1110693010711 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1110693010712 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1110693010713 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1110693010714 FMN reductase; Validated; Region: fre; PRK08051 1110693010715 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1110693010716 FAD binding pocket [chemical binding]; other site 1110693010717 FAD binding motif [chemical binding]; other site 1110693010718 phosphate binding motif [ion binding]; other site 1110693010719 beta-alpha-beta structure motif; other site 1110693010720 NAD binding pocket [chemical binding]; other site 1110693010721 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1110693010722 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1110693010723 dimer interface [polypeptide binding]; other site 1110693010724 active site 1110693010725 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1110693010726 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1110693010727 substrate binding site [chemical binding]; other site 1110693010728 oxyanion hole (OAH) forming residues; other site 1110693010729 trimer interface [polypeptide binding]; other site 1110693010730 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1110693010731 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1110693010732 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1110693010733 proline dipeptidase; Provisional; Region: PRK13607 1110693010734 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1110693010735 active site 1110693010736 hypothetical protein; Provisional; Region: PRK11568 1110693010737 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1110693010738 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1110693010739 potassium transporter; Provisional; Region: PRK10750 1110693010740 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1110693010741 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1110693010742 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1110693010743 Walker A motif; other site 1110693010744 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1110693010745 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1110693010746 GTP binding site; other site 1110693010747 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1110693010748 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1110693010749 serine/threonine protein kinase; Provisional; Region: PRK11768 1110693010750 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1110693010751 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1110693010752 catalytic residues [active] 1110693010753 hinge region; other site 1110693010754 alpha helical domain; other site 1110693010755 hypothetical protein; Provisional; Region: PRK11367 1110693010756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1110693010757 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1110693010758 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1110693010759 putative acyl-acceptor binding pocket; other site 1110693010760 DNA polymerase I; Provisional; Region: PRK05755 1110693010761 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1110693010762 active site 1110693010763 metal binding site 1 [ion binding]; metal-binding site 1110693010764 putative 5' ssDNA interaction site; other site 1110693010765 metal binding site 3; metal-binding site 1110693010766 metal binding site 2 [ion binding]; metal-binding site 1110693010767 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1110693010768 putative DNA binding site [nucleotide binding]; other site 1110693010769 putative metal binding site [ion binding]; other site 1110693010770 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1110693010771 active site 1110693010772 catalytic site [active] 1110693010773 substrate binding site [chemical binding]; other site 1110693010774 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1110693010775 active site 1110693010776 DNA binding site [nucleotide binding] 1110693010777 catalytic site [active] 1110693010778 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1110693010779 G1 box; other site 1110693010780 GTP/Mg2+ binding site [chemical binding]; other site 1110693010781 Switch I region; other site 1110693010782 G2 box; other site 1110693010783 G3 box; other site 1110693010784 Switch II region; other site 1110693010785 G4 box; other site 1110693010786 G5 box; other site 1110693010787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 1110693010788 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1110693010789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693010790 FeS/SAM binding site; other site 1110693010791 HemN C-terminal domain; Region: HemN_C; pfam06969 1110693010792 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1110693010793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693010794 active site 1110693010795 phosphorylation site [posttranslational modification] 1110693010796 intermolecular recognition site; other site 1110693010797 dimerization interface [polypeptide binding]; other site 1110693010798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693010799 Walker A motif; other site 1110693010800 ATP binding site [chemical binding]; other site 1110693010801 Walker B motif; other site 1110693010802 arginine finger; other site 1110693010803 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1110693010804 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1110693010805 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1110693010806 putative active site [active] 1110693010807 heme pocket [chemical binding]; other site 1110693010808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693010809 dimer interface [polypeptide binding]; other site 1110693010810 phosphorylation site [posttranslational modification] 1110693010811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693010812 ATP binding site [chemical binding]; other site 1110693010813 Mg2+ binding site [ion binding]; other site 1110693010814 G-X-G motif; other site 1110693010815 glutamine synthetase; Provisional; Region: glnA; PRK09469 1110693010816 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1110693010817 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1110693010818 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1110693010819 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1110693010820 G1 box; other site 1110693010821 putative GEF interaction site [polypeptide binding]; other site 1110693010822 GTP/Mg2+ binding site [chemical binding]; other site 1110693010823 Switch I region; other site 1110693010824 G2 box; other site 1110693010825 G3 box; other site 1110693010826 Switch II region; other site 1110693010827 G4 box; other site 1110693010828 G5 box; other site 1110693010829 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1110693010830 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1110693010831 transcriptional regulator protein; Region: phnR; TIGR03337 1110693010832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693010833 DNA-binding site [nucleotide binding]; DNA binding site 1110693010834 UTRA domain; Region: UTRA; pfam07702 1110693010835 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1110693010836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693010837 putative substrate translocation pore; other site 1110693010838 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1110693010839 outer membrane porin L; Provisional; Region: ompL; PRK09980 1110693010840 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1110693010841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693010842 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1110693010843 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1110693010844 alpha-glucosidase; Provisional; Region: PRK10426 1110693010845 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1110693010846 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1110693010847 putative active site [active] 1110693010848 putative catalytic site [active] 1110693010849 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1110693010850 active site 1110693010851 catalytic residues [active] 1110693010852 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1110693010853 dimerization interface [polypeptide binding]; other site 1110693010854 putative active cleft [active] 1110693010855 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 1110693010856 catalytic residue [active] 1110693010857 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1110693010858 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1110693010859 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1110693010860 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1110693010861 substrate binding site [chemical binding]; other site 1110693010862 ATP binding site [chemical binding]; other site 1110693010863 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1110693010864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1110693010865 putative DNA binding site [nucleotide binding]; other site 1110693010866 putative Zn2+ binding site [ion binding]; other site 1110693010867 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1110693010868 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1110693010869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693010870 motif II; other site 1110693010871 hypothetical protein; Reviewed; Region: PRK01637 1110693010872 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1110693010873 putative active site [active] 1110693010874 dimerization interface [polypeptide binding]; other site 1110693010875 putative tRNAtyr binding site [nucleotide binding]; other site 1110693010876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1110693010877 Coenzyme A binding pocket [chemical binding]; other site 1110693010878 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1110693010879 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1110693010880 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1110693010881 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1110693010882 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1110693010883 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1110693010884 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1110693010885 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1110693010886 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1110693010887 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1110693010888 [4Fe-4S] binding site [ion binding]; other site 1110693010889 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1110693010890 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1110693010891 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1110693010892 molybdopterin cofactor binding site; other site 1110693010893 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1110693010894 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1110693010895 putative frv operon regulatory protein; Provisional; Region: PRK09863 1110693010896 HTH domain; Region: HTH_11; pfam08279 1110693010897 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1110693010898 active site 1110693010899 phosphorylation site [posttranslational modification] 1110693010900 putative peptidase; Provisional; Region: PRK09864 1110693010901 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1110693010902 oligomer interface [polypeptide binding]; other site 1110693010903 active site 1110693010904 metal binding site [ion binding]; metal-binding site 1110693010905 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1110693010906 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1110693010907 active site 1110693010908 P-loop; other site 1110693010909 phosphorylation site [posttranslational modification] 1110693010910 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1110693010911 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1110693010912 active site 1110693010913 phosphorylation site [posttranslational modification] 1110693010914 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1110693010915 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1110693010916 intersubunit interface [polypeptide binding]; other site 1110693010917 active site 1110693010918 Zn2+ binding site [ion binding]; other site 1110693010919 L-rhamnose isomerase; Provisional; Region: PRK01076 1110693010920 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1110693010921 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1110693010922 N- and C-terminal domain interface [polypeptide binding]; other site 1110693010923 active site 1110693010924 putative catalytic site [active] 1110693010925 metal binding site [ion binding]; metal-binding site 1110693010926 ATP binding site [chemical binding]; other site 1110693010927 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1110693010928 carbohydrate binding site [chemical binding]; other site 1110693010929 transcriptional activator RhaS; Provisional; Region: PRK13503 1110693010930 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1110693010931 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693010932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693010933 transcriptional activator RhaR; Provisional; Region: PRK13500 1110693010934 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1110693010935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693010936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693010937 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1110693010938 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1110693010939 superoxide dismutase; Provisional; Region: PRK10925 1110693010940 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1110693010941 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1110693010942 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 1110693010943 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1110693010944 MOSC domain; Region: MOSC; pfam03473 1110693010945 3-alpha domain; Region: 3-alpha; pfam03475 1110693010946 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1110693010947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1110693010948 dimerization interface [polypeptide binding]; other site 1110693010949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693010950 dimer interface [polypeptide binding]; other site 1110693010951 phosphorylation site [posttranslational modification] 1110693010952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693010953 ATP binding site [chemical binding]; other site 1110693010954 Mg2+ binding site [ion binding]; other site 1110693010955 G-X-G motif; other site 1110693010956 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1110693010957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693010958 active site 1110693010959 intermolecular recognition site; other site 1110693010960 dimerization interface [polypeptide binding]; other site 1110693010961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693010962 DNA binding site [nucleotide binding] 1110693010963 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1110693010964 dimer interface [polypeptide binding]; other site 1110693010965 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1110693010966 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1110693010967 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1110693010968 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1110693010969 active site 1110693010970 ADP/pyrophosphate binding site [chemical binding]; other site 1110693010971 dimerization interface [polypeptide binding]; other site 1110693010972 allosteric effector site; other site 1110693010973 fructose-1,6-bisphosphate binding site; other site 1110693010974 sulfate transporter subunit; Provisional; Region: PRK10752 1110693010975 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1110693010976 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 1110693010977 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1110693010978 triosephosphate isomerase; Provisional; Region: PRK14567 1110693010979 substrate binding site [chemical binding]; other site 1110693010980 dimer interface [polypeptide binding]; other site 1110693010981 catalytic triad [active] 1110693010982 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1110693010983 Predicted membrane protein [Function unknown]; Region: COG3152 1110693010984 hypothetical protein; Provisional; Region: PRK09981 1110693010985 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1110693010986 Ligand Binding Site [chemical binding]; other site 1110693010987 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1110693010988 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1110693010989 FAD binding pocket [chemical binding]; other site 1110693010990 FAD binding motif [chemical binding]; other site 1110693010991 phosphate binding motif [ion binding]; other site 1110693010992 beta-alpha-beta structure motif; other site 1110693010993 NAD binding pocket [chemical binding]; other site 1110693010994 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1110693010995 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1110693010996 putative active site [active] 1110693010997 glycerol kinase; Provisional; Region: glpK; PRK00047 1110693010998 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1110693010999 N- and C-terminal domain interface [polypeptide binding]; other site 1110693011000 active site 1110693011001 MgATP binding site [chemical binding]; other site 1110693011002 catalytic site [active] 1110693011003 metal binding site [ion binding]; metal-binding site 1110693011004 glycerol binding site [chemical binding]; other site 1110693011005 homotetramer interface [polypeptide binding]; other site 1110693011006 homodimer interface [polypeptide binding]; other site 1110693011007 FBP binding site [chemical binding]; other site 1110693011008 protein IIAGlc interface [polypeptide binding]; other site 1110693011009 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1110693011010 amphipathic channel; other site 1110693011011 Asn-Pro-Ala signature motifs; other site 1110693011012 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1110693011013 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1110693011014 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1110693011015 UbiA prenyltransferase family; Region: UbiA; pfam01040 1110693011016 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1110693011017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693011018 Walker A motif; other site 1110693011019 ATP binding site [chemical binding]; other site 1110693011020 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1110693011021 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1110693011022 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1110693011023 active site 1110693011024 HslU subunit interaction site [polypeptide binding]; other site 1110693011025 essential cell division protein FtsN; Provisional; Region: PRK10927 1110693011026 cell division protein FtsN; Provisional; Region: PRK12757 1110693011027 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693011028 DNA binding site [nucleotide binding] 1110693011029 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1110693011030 domain linker motif; other site 1110693011031 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1110693011032 dimerization interface [polypeptide binding]; other site 1110693011033 ligand binding site [chemical binding]; other site 1110693011034 primosome assembly protein PriA; Validated; Region: PRK05580 1110693011035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1110693011036 ATP binding site [chemical binding]; other site 1110693011037 putative Mg++ binding site [ion binding]; other site 1110693011038 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1110693011039 ATP-binding site [chemical binding]; other site 1110693011040 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1110693011041 hypothetical protein; Provisional; Region: PRK10030 1110693011042 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1110693011043 dimerization interface [polypeptide binding]; other site 1110693011044 DNA binding site [nucleotide binding] 1110693011045 corepressor binding sites; other site 1110693011046 cystathionine gamma-synthase; Provisional; Region: PRK08045 1110693011047 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1110693011048 homodimer interface [polypeptide binding]; other site 1110693011049 substrate-cofactor binding pocket; other site 1110693011050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693011051 catalytic residue [active] 1110693011052 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1110693011053 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1110693011054 putative catalytic residues [active] 1110693011055 putative nucleotide binding site [chemical binding]; other site 1110693011056 putative aspartate binding site [chemical binding]; other site 1110693011057 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1110693011058 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1110693011059 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1110693011060 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1110693011061 FAD binding site [chemical binding]; other site 1110693011062 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1110693011063 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1110693011064 heme binding site [chemical binding]; other site 1110693011065 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1110693011066 EamA-like transporter family; Region: EamA; pfam00892 1110693011067 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1110693011068 EamA-like transporter family; Region: EamA; pfam00892 1110693011069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 1110693011070 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1110693011071 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1110693011072 dimer interface [polypeptide binding]; other site 1110693011073 active site 1110693011074 metal binding site [ion binding]; metal-binding site 1110693011075 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1110693011076 active site 1110693011077 intersubunit interactions; other site 1110693011078 catalytic residue [active] 1110693011079 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1110693011080 dimerization domain swap beta strand [polypeptide binding]; other site 1110693011081 regulatory protein interface [polypeptide binding]; other site 1110693011082 active site 1110693011083 regulatory phosphorylation site [posttranslational modification]; other site 1110693011084 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1110693011085 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1110693011086 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1110693011087 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1110693011088 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1110693011089 active site 1110693011090 phosphorylation site [posttranslational modification] 1110693011091 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 1110693011092 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1110693011093 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1110693011094 active site 1110693011095 P-loop; other site 1110693011096 phosphorylation site [posttranslational modification] 1110693011097 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 1110693011098 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1110693011099 dimer interface [polypeptide binding]; other site 1110693011100 active site 1110693011101 glycine loop; other site 1110693011102 pyruvate formate lyase II activase; Provisional; Region: PRK10076 1110693011103 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1110693011104 active site 1110693011105 P-loop; other site 1110693011106 phosphorylation site [posttranslational modification] 1110693011107 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1110693011108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693011109 hypothetical protein; Provisional; Region: PRK10649 1110693011110 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1110693011111 Sulfatase; Region: Sulfatase; pfam00884 1110693011112 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1110693011113 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1110693011114 acetylornithine deacetylase; Provisional; Region: PRK05111 1110693011115 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1110693011116 metal binding site [ion binding]; metal-binding site 1110693011117 putative dimer interface [polypeptide binding]; other site 1110693011118 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1110693011119 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1110693011120 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1110693011121 nucleotide binding site [chemical binding]; other site 1110693011122 N-acetyl-L-glutamate binding site [chemical binding]; other site 1110693011123 argininosuccinate lyase; Provisional; Region: PRK04833 1110693011124 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1110693011125 active sites [active] 1110693011126 tetramer interface [polypeptide binding]; other site 1110693011127 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1110693011128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1110693011129 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1110693011130 dimerization interface [polypeptide binding]; other site 1110693011131 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1110693011132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1110693011133 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1110693011134 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1110693011135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1110693011136 hypothetical protein; Provisional; Region: PRK11056 1110693011137 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1110693011138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693011139 S-adenosylmethionine binding site [chemical binding]; other site 1110693011140 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1110693011141 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1110693011142 N-terminal plug; other site 1110693011143 ligand-binding site [chemical binding]; other site 1110693011144 glutamate racemase; Provisional; Region: PRK00865 1110693011145 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1110693011146 FAD binding domain; Region: FAD_binding_4; pfam01565 1110693011147 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1110693011148 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1110693011149 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1110693011150 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1110693011151 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1110693011152 pantothenate kinase; Provisional; Region: PRK05439 1110693011153 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1110693011154 ATP-binding site [chemical binding]; other site 1110693011155 CoA-binding site [chemical binding]; other site 1110693011156 Mg2+-binding site [ion binding]; other site 1110693011157 elongation factor Tu; Reviewed; Region: PRK00049 1110693011158 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1110693011159 G1 box; other site 1110693011160 GEF interaction site [polypeptide binding]; other site 1110693011161 GTP/Mg2+ binding site [chemical binding]; other site 1110693011162 Switch I region; other site 1110693011163 G2 box; other site 1110693011164 G3 box; other site 1110693011165 Switch II region; other site 1110693011166 G4 box; other site 1110693011167 G5 box; other site 1110693011168 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1110693011169 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1110693011170 Antibiotic Binding Site [chemical binding]; other site 1110693011171 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1110693011172 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1110693011173 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1110693011174 putative homodimer interface [polypeptide binding]; other site 1110693011175 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1110693011176 heterodimer interface [polypeptide binding]; other site 1110693011177 homodimer interface [polypeptide binding]; other site 1110693011178 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1110693011179 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1110693011180 23S rRNA interface [nucleotide binding]; other site 1110693011181 L7/L12 interface [polypeptide binding]; other site 1110693011182 putative thiostrepton binding site; other site 1110693011183 L25 interface [polypeptide binding]; other site 1110693011184 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1110693011185 mRNA/rRNA interface [nucleotide binding]; other site 1110693011186 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1110693011187 23S rRNA interface [nucleotide binding]; other site 1110693011188 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1110693011189 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1110693011190 core dimer interface [polypeptide binding]; other site 1110693011191 peripheral dimer interface [polypeptide binding]; other site 1110693011192 L10 interface [polypeptide binding]; other site 1110693011193 L11 interface [polypeptide binding]; other site 1110693011194 putative EF-Tu interaction site [polypeptide binding]; other site 1110693011195 putative EF-G interaction site [polypeptide binding]; other site 1110693011196 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1110693011197 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1110693011198 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1110693011199 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1110693011200 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1110693011201 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1110693011202 RPB3 interaction site [polypeptide binding]; other site 1110693011203 RPB1 interaction site [polypeptide binding]; other site 1110693011204 RPB11 interaction site [polypeptide binding]; other site 1110693011205 RPB10 interaction site [polypeptide binding]; other site 1110693011206 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1110693011207 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1110693011208 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1110693011209 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1110693011210 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1110693011211 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1110693011212 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1110693011213 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1110693011214 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1110693011215 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1110693011216 DNA binding site [nucleotide binding] 1110693011217 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1110693011218 stationary phase growth adaptation protein; Provisional; Region: PRK09717 1110693011219 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1110693011220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693011221 FeS/SAM binding site; other site 1110693011222 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1110693011223 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1110693011224 ThiS interaction site; other site 1110693011225 putative active site [active] 1110693011226 tetramer interface [polypeptide binding]; other site 1110693011227 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1110693011228 thiS-thiF/thiG interaction site; other site 1110693011229 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1110693011230 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1110693011231 ATP binding site [chemical binding]; other site 1110693011232 substrate interface [chemical binding]; other site 1110693011233 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1110693011234 thiamine phosphate binding site [chemical binding]; other site 1110693011235 active site 1110693011236 pyrophosphate binding site [ion binding]; other site 1110693011237 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1110693011238 ThiC-associated domain; Region: ThiC-associated; pfam13667 1110693011239 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1110693011240 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 1110693011241 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1110693011242 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1110693011243 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1110693011244 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1110693011245 putative NADH binding site [chemical binding]; other site 1110693011246 putative active site [active] 1110693011247 nudix motif; other site 1110693011248 putative metal binding site [ion binding]; other site 1110693011249 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1110693011250 substrate binding site [chemical binding]; other site 1110693011251 active site 1110693011252 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1110693011253 Active_site [active] 1110693011254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1110693011255 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1110693011256 IHF dimer interface [polypeptide binding]; other site 1110693011257 IHF - DNA interface [nucleotide binding]; other site 1110693011258 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1110693011259 zinc resistance protein; Provisional; Region: zraP; PRK11546 1110693011260 dimer interface [polypeptide binding]; other site 1110693011261 sensor protein ZraS; Provisional; Region: PRK10364 1110693011262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693011263 dimer interface [polypeptide binding]; other site 1110693011264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693011265 ATP binding site [chemical binding]; other site 1110693011266 Mg2+ binding site [ion binding]; other site 1110693011267 G-X-G motif; other site 1110693011268 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 1110693011269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693011270 active site 1110693011271 phosphorylation site [posttranslational modification] 1110693011272 intermolecular recognition site; other site 1110693011273 dimerization interface [polypeptide binding]; other site 1110693011274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693011275 Walker A motif; other site 1110693011276 ATP binding site [chemical binding]; other site 1110693011277 Walker B motif; other site 1110693011278 arginine finger; other site 1110693011279 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1110693011280 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1110693011281 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1110693011282 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1110693011283 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1110693011284 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1110693011285 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1110693011286 purine monophosphate binding site [chemical binding]; other site 1110693011287 dimer interface [polypeptide binding]; other site 1110693011288 putative catalytic residues [active] 1110693011289 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1110693011290 hypothetical protein; Provisional; Region: PRK10039 1110693011291 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1110693011292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1110693011293 Coenzyme A binding pocket [chemical binding]; other site 1110693011294 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1110693011295 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1110693011296 proposed active site lysine [active] 1110693011297 conserved cys residue [active] 1110693011298 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1110693011299 malate synthase A; Region: malate_syn_A; TIGR01344 1110693011300 active site 1110693011301 isocitrate lyase; Provisional; Region: PRK15063 1110693011302 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1110693011303 tetramer interface [polypeptide binding]; other site 1110693011304 active site 1110693011305 Mg2+/Mn2+ binding site [ion binding]; other site 1110693011306 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1110693011307 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1110693011308 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 1110693011309 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1110693011310 transcriptional repressor IclR; Provisional; Region: PRK11569 1110693011311 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1110693011312 Bacterial transcriptional regulator; Region: IclR; pfam01614 1110693011313 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1110693011314 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1110693011315 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1110693011316 substrate binding pocket [chemical binding]; other site 1110693011317 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1110693011318 B12 binding site [chemical binding]; other site 1110693011319 cobalt ligand [ion binding]; other site 1110693011320 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1110693011321 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1110693011322 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1110693011323 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1110693011324 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1110693011325 active site pocket [active] 1110693011326 oxyanion hole [active] 1110693011327 catalytic triad [active] 1110693011328 active site nucleophile [active] 1110693011329 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1110693011330 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1110693011331 RNA binding surface [nucleotide binding]; other site 1110693011332 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1110693011333 probable active site [active] 1110693011334 hypothetical protein; Provisional; Region: PRK10515 1110693011335 aspartate kinase III; Validated; Region: PRK09084 1110693011336 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 1110693011337 nucleotide binding site [chemical binding]; other site 1110693011338 putative catalytic residues [active] 1110693011339 aspartate binding site [chemical binding]; other site 1110693011340 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 1110693011341 lysine allosteric regulatory site; other site 1110693011342 dimer interface [polypeptide binding]; other site 1110693011343 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1110693011344 dimer interface [polypeptide binding]; other site 1110693011345 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1110693011346 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1110693011347 active site 1110693011348 dimer interface [polypeptide binding]; other site 1110693011349 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1110693011350 dimer interface [polypeptide binding]; other site 1110693011351 active site 1110693011352 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1110693011353 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1110693011354 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1110693011355 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1110693011356 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1110693011357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693011358 putative substrate translocation pore; other site 1110693011359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693011360 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1110693011361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693011362 dimer interface [polypeptide binding]; other site 1110693011363 conserved gate region; other site 1110693011364 putative PBP binding loops; other site 1110693011365 ABC-ATPase subunit interface; other site 1110693011366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1110693011367 dimer interface [polypeptide binding]; other site 1110693011368 conserved gate region; other site 1110693011369 putative PBP binding loops; other site 1110693011370 ABC-ATPase subunit interface; other site 1110693011371 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1110693011372 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1110693011373 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1110693011374 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1110693011375 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1110693011376 Walker A/P-loop; other site 1110693011377 ATP binding site [chemical binding]; other site 1110693011378 Q-loop/lid; other site 1110693011379 ABC transporter signature motif; other site 1110693011380 Walker B; other site 1110693011381 D-loop; other site 1110693011382 H-loop/switch region; other site 1110693011383 TOBE domain; Region: TOBE_2; pfam08402 1110693011384 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1110693011385 trimer interface; other site 1110693011386 sugar binding site [chemical binding]; other site 1110693011387 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1110693011388 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1110693011389 SopA-like central domain; Region: SopA; pfam13981 1110693011390 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1110693011391 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1110693011392 UbiA prenyltransferase family; Region: UbiA; pfam01040 1110693011393 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1110693011394 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1110693011395 putative acyl-acceptor binding pocket; other site 1110693011396 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1110693011397 LexA repressor; Validated; Region: PRK00215 1110693011398 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1110693011399 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1110693011400 Catalytic site [active] 1110693011401 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1110693011402 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1110693011403 hypothetical protein; Provisional; Region: PRK10428 1110693011404 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1110693011405 metal binding site 2 [ion binding]; metal-binding site 1110693011406 putative DNA binding helix; other site 1110693011407 metal binding site 1 [ion binding]; metal-binding site 1110693011408 dimer interface [polypeptide binding]; other site 1110693011409 structural Zn2+ binding site [ion binding]; other site 1110693011410 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 1110693011411 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1110693011412 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1110693011413 FMN binding site [chemical binding]; other site 1110693011414 active site 1110693011415 catalytic residues [active] 1110693011416 substrate binding site [chemical binding]; other site 1110693011417 phage shock protein G; Reviewed; Region: pspG; PRK09459 1110693011418 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1110693011419 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1110693011420 NADP binding site [chemical binding]; other site 1110693011421 dimer interface [polypeptide binding]; other site 1110693011422 replicative DNA helicase; Provisional; Region: PRK08006 1110693011423 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1110693011424 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1110693011425 Walker A motif; other site 1110693011426 ATP binding site [chemical binding]; other site 1110693011427 Walker B motif; other site 1110693011428 DNA binding loops [nucleotide binding] 1110693011429 alanine racemase; Reviewed; Region: alr; PRK00053 1110693011430 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1110693011431 active site 1110693011432 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1110693011433 substrate binding site [chemical binding]; other site 1110693011434 catalytic residues [active] 1110693011435 dimer interface [polypeptide binding]; other site 1110693011436 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1110693011437 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1110693011438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693011439 homodimer interface [polypeptide binding]; other site 1110693011440 catalytic residue [active] 1110693011441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693011442 active site 1110693011443 motif I; other site 1110693011444 motif II; other site 1110693011445 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1110693011446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1110693011447 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1110693011448 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1110693011449 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1110693011450 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1110693011451 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1110693011452 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1110693011453 dimer interface [polypeptide binding]; other site 1110693011454 ssDNA binding site [nucleotide binding]; other site 1110693011455 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1110693011456 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1110693011457 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1110693011458 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1110693011459 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1110693011460 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1110693011461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693011462 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1110693011463 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1110693011464 DNA binding residues [nucleotide binding] 1110693011465 dimer interface [polypeptide binding]; other site 1110693011466 [2Fe-2S] cluster binding site [ion binding]; other site 1110693011467 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1110693011468 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1110693011469 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1110693011470 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1110693011471 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1110693011472 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1110693011473 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1110693011474 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1110693011475 Na binding site [ion binding]; other site 1110693011476 Predicted membrane protein [Function unknown]; Region: COG3162 1110693011477 acetyl-CoA synthetase; Provisional; Region: PRK00174 1110693011478 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1110693011479 active site 1110693011480 CoA binding site [chemical binding]; other site 1110693011481 acyl-activating enzyme (AAE) consensus motif; other site 1110693011482 AMP binding site [chemical binding]; other site 1110693011483 acetate binding site [chemical binding]; other site 1110693011484 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 1110693011485 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 1110693011486 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1110693011487 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1110693011488 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1110693011489 heme lyase subunit NrfE; Provisional; Region: PRK10369 1110693011490 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 1110693011491 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1110693011492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1110693011493 binding surface 1110693011494 TPR motif; other site 1110693011495 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1110693011496 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1110693011497 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1110693011498 Sel1-like repeats; Region: SEL1; smart00671 1110693011499 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1110693011500 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1110693011501 [4Fe-4S] binding site [ion binding]; other site 1110693011502 molybdopterin cofactor binding site; other site 1110693011503 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1110693011504 molybdopterin cofactor binding site; other site 1110693011505 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 1110693011506 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 1110693011507 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1110693011508 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1110693011509 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1110693011510 HlyD family secretion protein; Region: HlyD_3; pfam13437 1110693011511 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1110693011512 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1110693011513 D-allose kinase; Provisional; Region: PRK09698 1110693011514 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1110693011515 nucleotide binding site [chemical binding]; other site 1110693011516 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1110693011517 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1110693011518 substrate binding site [chemical binding]; other site 1110693011519 hexamer interface [polypeptide binding]; other site 1110693011520 metal binding site [ion binding]; metal-binding site 1110693011521 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1110693011522 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1110693011523 TM-ABC transporter signature motif; other site 1110693011524 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 1110693011525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693011526 Walker A/P-loop; other site 1110693011527 ATP binding site [chemical binding]; other site 1110693011528 Q-loop/lid; other site 1110693011529 ABC transporter signature motif; other site 1110693011530 Walker B; other site 1110693011531 D-loop; other site 1110693011532 H-loop/switch region; other site 1110693011533 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1110693011534 D-allose transporter subunit; Provisional; Region: PRK09701 1110693011535 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 1110693011536 ligand binding site [chemical binding]; other site 1110693011537 dimerization interface [polypeptide binding]; other site 1110693011538 zinc binding site [ion binding]; other site 1110693011539 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 1110693011540 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1110693011541 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1110693011542 putative active site [active] 1110693011543 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 1110693011544 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 1110693011545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1110693011546 Coenzyme A binding pocket [chemical binding]; other site 1110693011547 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 1110693011548 AAA domain; Region: AAA_18; pfam13238 1110693011549 active site 1110693011550 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1110693011551 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1110693011552 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1110693011553 active site 1110693011554 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1110693011555 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1110693011556 Walker A/P-loop; other site 1110693011557 ATP binding site [chemical binding]; other site 1110693011558 Q-loop/lid; other site 1110693011559 ABC transporter signature motif; other site 1110693011560 Walker B; other site 1110693011561 D-loop; other site 1110693011562 H-loop/switch region; other site 1110693011563 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1110693011564 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1110693011565 Walker A/P-loop; other site 1110693011566 ATP binding site [chemical binding]; other site 1110693011567 Q-loop/lid; other site 1110693011568 ABC transporter signature motif; other site 1110693011569 Walker B; other site 1110693011570 D-loop; other site 1110693011571 H-loop/switch region; other site 1110693011572 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1110693011573 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1110693011574 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 1110693011575 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 1110693011576 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1110693011577 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 1110693011578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693011579 DNA-binding site [nucleotide binding]; DNA binding site 1110693011580 UTRA domain; Region: UTRA; pfam07702 1110693011581 phosphonate/organophosphate ester transporter (pseudogene) 1110693011582 phosphonate/organophosphate ester transporter subunit 1110693011583 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1110693011584 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1110693011585 substrate binding pocket [chemical binding]; other site 1110693011586 membrane-bound complex binding site; other site 1110693011587 hinge residues; other site 1110693011588 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 1110693011589 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1110693011590 Walker A/P-loop; other site 1110693011591 ATP binding site [chemical binding]; other site 1110693011592 Q-loop/lid; other site 1110693011593 ABC transporter signature motif; other site 1110693011594 Walker B; other site 1110693011595 D-loop; other site 1110693011596 H-loop/switch region; other site 1110693011597 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1110693011598 dimer interface [polypeptide binding]; other site 1110693011599 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1110693011600 hypothetical protein; Provisional; Region: PRK10220 1110693011601 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1110693011602 PhnA protein; Region: PhnA; pfam03831 1110693011603 hypothetical protein; Provisional; Region: PRK09866 1110693011604 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1110693011605 G1 box; other site 1110693011606 GTP/Mg2+ binding site [chemical binding]; other site 1110693011607 G2 box; other site 1110693011608 Switch I region; other site 1110693011609 G3 box; other site 1110693011610 Switch II region; other site 1110693011611 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1110693011612 G2 box; other site 1110693011613 Switch I region; other site 1110693011614 G3 box; other site 1110693011615 Switch II region; other site 1110693011616 G4 box; other site 1110693011617 G5 box; other site 1110693011618 YjcZ-like protein; Region: YjcZ; pfam13990 1110693011619 proline/glycine betaine transporter; Provisional; Region: PRK10642 1110693011620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693011621 putative substrate translocation pore; other site 1110693011622 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1110693011623 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1110693011624 HAMP domain; Region: HAMP; pfam00672 1110693011625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693011626 dimer interface [polypeptide binding]; other site 1110693011627 phosphorylation site [posttranslational modification] 1110693011628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693011629 ATP binding site [chemical binding]; other site 1110693011630 Mg2+ binding site [ion binding]; other site 1110693011631 G-X-G motif; other site 1110693011632 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1110693011633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693011634 active site 1110693011635 phosphorylation site [posttranslational modification] 1110693011636 intermolecular recognition site; other site 1110693011637 dimerization interface [polypeptide binding]; other site 1110693011638 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693011639 DNA binding site [nucleotide binding] 1110693011640 putative metal dependent hydrolase; Provisional; Region: PRK11598 1110693011641 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1110693011642 Sulfatase; Region: Sulfatase; pfam00884 1110693011643 arginine:agmatin antiporter; Provisional; Region: PRK10644 1110693011644 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1110693011645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693011646 arginine decarboxylase; Provisional; Region: PRK15029 1110693011647 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1110693011648 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1110693011649 homodimer interface [polypeptide binding]; other site 1110693011650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693011651 catalytic residue [active] 1110693011652 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1110693011653 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 1110693011654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693011655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693011656 alpha-galactosidase; Provisional; Region: PRK15076 1110693011657 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1110693011658 NAD binding site [chemical binding]; other site 1110693011659 sugar binding site [chemical binding]; other site 1110693011660 divalent metal binding site [ion binding]; other site 1110693011661 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1110693011662 dimer interface [polypeptide binding]; other site 1110693011663 melibiose:sodium symporter; Provisional; Region: PRK10429 1110693011664 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1110693011665 hypothetical protein; Provisional; Region: PRK09867 1110693011666 fumarate hydratase; Provisional; Region: PRK15389 1110693011667 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1110693011668 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1110693011669 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1110693011670 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1110693011671 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1110693011672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693011673 active site 1110693011674 phosphorylation site [posttranslational modification] 1110693011675 intermolecular recognition site; other site 1110693011676 dimerization interface [polypeptide binding]; other site 1110693011677 Transcriptional regulator; Region: CitT; pfam12431 1110693011678 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1110693011679 PAS domain; Region: PAS; smart00091 1110693011680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693011681 ATP binding site [chemical binding]; other site 1110693011682 Mg2+ binding site [ion binding]; other site 1110693011683 G-X-G motif; other site 1110693011684 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1110693011685 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1110693011686 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1110693011687 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1110693011688 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1110693011689 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1110693011690 dimer interface [polypeptide binding]; other site 1110693011691 putative anticodon binding site; other site 1110693011692 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1110693011693 motif 1; other site 1110693011694 active site 1110693011695 motif 2; other site 1110693011696 motif 3; other site 1110693011697 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1110693011698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1110693011699 putative substrate translocation pore; other site 1110693011700 POT family; Region: PTR2; pfam00854 1110693011701 lysine decarboxylase CadA; Provisional; Region: PRK15400 1110693011702 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1110693011703 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1110693011704 homodimer interface [polypeptide binding]; other site 1110693011705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1110693011706 catalytic residue [active] 1110693011707 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1110693011708 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1110693011709 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1110693011710 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693011711 DNA binding site [nucleotide binding] 1110693011712 putative transcriptional regulator; Provisional; Region: PRK11640 1110693011713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1110693011714 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1110693011715 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1110693011716 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1110693011717 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1110693011718 DsbD alpha interface [polypeptide binding]; other site 1110693011719 catalytic residues [active] 1110693011720 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1110693011721 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1110693011722 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1110693011723 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1110693011724 Aspartase; Region: Aspartase; cd01357 1110693011725 active sites [active] 1110693011726 tetramer interface [polypeptide binding]; other site 1110693011727 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1110693011728 putative transporter; Provisional; Region: PRK11021 1110693011729 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1110693011730 oligomerisation interface [polypeptide binding]; other site 1110693011731 mobile loop; other site 1110693011732 roof hairpin; other site 1110693011733 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1110693011734 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1110693011735 ring oligomerisation interface [polypeptide binding]; other site 1110693011736 ATP/Mg binding site [chemical binding]; other site 1110693011737 stacking interactions; other site 1110693011738 hinge regions; other site 1110693011739 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1110693011740 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1110693011741 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693011742 FeS/SAM binding site; other site 1110693011743 elongation factor P; Validated; Region: PRK00529 1110693011744 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1110693011745 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1110693011746 RNA binding site [nucleotide binding]; other site 1110693011747 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1110693011748 RNA binding site [nucleotide binding]; other site 1110693011749 entericidin A; Provisional; Region: PRK09810 1110693011750 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1110693011751 multidrug efflux system protein; Provisional; Region: PRK11431 1110693011752 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1110693011753 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1110693011754 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1110693011755 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1110693011756 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1110693011757 Iron-sulfur protein interface; other site 1110693011758 proximal quinone binding site [chemical binding]; other site 1110693011759 C-subunit interface; other site 1110693011760 distal quinone binding site; other site 1110693011761 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1110693011762 D-subunit interface [polypeptide binding]; other site 1110693011763 Iron-sulfur protein interface; other site 1110693011764 proximal quinone binding site [chemical binding]; other site 1110693011765 distal quinone binding site [chemical binding]; other site 1110693011766 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1110693011767 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1110693011768 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1110693011769 L-aspartate oxidase; Provisional; Region: PRK06175 1110693011770 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1110693011771 poxB regulator PoxA; Provisional; Region: PRK09350 1110693011772 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1110693011773 motif 1; other site 1110693011774 dimer interface [polypeptide binding]; other site 1110693011775 active site 1110693011776 motif 2; other site 1110693011777 motif 3; other site 1110693011778 inner membrane transporter YjeM; Provisional; Region: PRK15238 1110693011779 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 1110693011780 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1110693011781 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 1110693011782 DNA-binding site [nucleotide binding]; DNA binding site 1110693011783 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1110693011784 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1110693011785 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1110693011786 GTPase RsgA; Reviewed; Region: PRK12288 1110693011787 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1110693011788 RNA binding site [nucleotide binding]; other site 1110693011789 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1110693011790 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1110693011791 GTP/Mg2+ binding site [chemical binding]; other site 1110693011792 G4 box; other site 1110693011793 G5 box; other site 1110693011794 G1 box; other site 1110693011795 Switch I region; other site 1110693011796 G2 box; other site 1110693011797 G3 box; other site 1110693011798 Switch II region; other site 1110693011799 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1110693011800 catalytic site [active] 1110693011801 putative active site [active] 1110693011802 putative substrate binding site [chemical binding]; other site 1110693011803 dimer interface [polypeptide binding]; other site 1110693011804 epoxyqueuosine reductase; Region: TIGR00276 1110693011805 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1110693011806 putative carbohydrate kinase; Provisional; Region: PRK10565 1110693011807 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 1110693011808 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1110693011809 putative substrate binding site [chemical binding]; other site 1110693011810 putative ATP binding site [chemical binding]; other site 1110693011811 ADP-binding protein; Provisional; Region: PRK10646 1110693011812 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1110693011813 AMIN domain; Region: AMIN; pfam11741 1110693011814 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1110693011815 active site 1110693011816 metal binding site [ion binding]; metal-binding site 1110693011817 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1110693011818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693011819 ATP binding site [chemical binding]; other site 1110693011820 Mg2+ binding site [ion binding]; other site 1110693011821 G-X-G motif; other site 1110693011822 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1110693011823 ATP binding site [chemical binding]; other site 1110693011824 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1110693011825 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1110693011826 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1110693011827 bacterial Hfq-like; Region: Hfq; cd01716 1110693011828 hexamer interface [polypeptide binding]; other site 1110693011829 Sm1 motif; other site 1110693011830 RNA binding site [nucleotide binding]; other site 1110693011831 Sm2 motif; other site 1110693011832 GTPase HflX; Provisional; Region: PRK11058 1110693011833 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1110693011834 HflX GTPase family; Region: HflX; cd01878 1110693011835 G1 box; other site 1110693011836 GTP/Mg2+ binding site [chemical binding]; other site 1110693011837 Switch I region; other site 1110693011838 G2 box; other site 1110693011839 G3 box; other site 1110693011840 Switch II region; other site 1110693011841 G4 box; other site 1110693011842 G5 box; other site 1110693011843 FtsH protease regulator HflK; Provisional; Region: PRK10930 1110693011844 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1110693011845 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1110693011846 FtsH protease regulator HflC; Provisional; Region: PRK11029 1110693011847 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1110693011848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1110693011849 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1110693011850 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1110693011851 GDP-binding site [chemical binding]; other site 1110693011852 ACT binding site; other site 1110693011853 IMP binding site; other site 1110693011854 Predicted transcriptional regulator [Transcription]; Region: COG1959 1110693011855 transcriptional repressor NsrR; Provisional; Region: PRK11014 1110693011856 exoribonuclease R; Provisional; Region: PRK11642 1110693011857 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1110693011858 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1110693011859 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1110693011860 RNB domain; Region: RNB; pfam00773 1110693011861 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1110693011862 RNA binding site [nucleotide binding]; other site 1110693011863 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1110693011864 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1110693011865 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1110693011866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 1110693011867 PspA/IM30 family; Region: PspA_IM30; pfam04012 1110693011868 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1110693011869 Predicted membrane protein [Function unknown]; Region: COG3766 1110693011870 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1110693011871 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1110693011872 Predicted integral membrane protein [Function unknown]; Region: COG5463 1110693011873 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1110693011874 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1110693011875 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1110693011876 FAD binding site [chemical binding]; other site 1110693011877 substrate binding site [chemical binding]; other site 1110693011878 catalytic residues [active] 1110693011879 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1110693011880 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1110693011881 esterase; Provisional; Region: PRK10566 1110693011882 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1110693011883 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1110693011884 transcriptional repressor UlaR; Provisional; Region: PRK13509 1110693011885 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1110693011886 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1110693011887 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1110693011888 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1110693011889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1110693011890 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1110693011891 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1110693011892 active site 1110693011893 P-loop; other site 1110693011894 phosphorylation site [posttranslational modification] 1110693011895 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1110693011896 active site 1110693011897 phosphorylation site [posttranslational modification] 1110693011898 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1110693011899 active site 1110693011900 dimer interface [polypeptide binding]; other site 1110693011901 magnesium binding site [ion binding]; other site 1110693011902 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1110693011903 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1110693011904 AP (apurinic/apyrimidinic) site pocket; other site 1110693011905 DNA interaction; other site 1110693011906 Metal-binding active site; metal-binding site 1110693011907 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1110693011908 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1110693011909 intersubunit interface [polypeptide binding]; other site 1110693011910 active site 1110693011911 Zn2+ binding site [ion binding]; other site 1110693011912 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1110693011913 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1110693011914 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1110693011915 dimer interface [polypeptide binding]; other site 1110693011916 ssDNA binding site [nucleotide binding]; other site 1110693011917 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1110693011918 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1110693011919 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1110693011920 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1110693011921 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1110693011922 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 1110693011923 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1110693011924 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1110693011925 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1110693011926 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1110693011927 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1110693011928 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1110693011929 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1110693011930 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1110693011931 Hemerythrin-like domain; Region: Hr-like; cd12108 1110693011932 Fe binding site [ion binding]; other site 1110693011933 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1110693011934 EamA-like transporter family; Region: EamA; pfam00892 1110693011935 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1110693011936 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1110693011937 NADP binding site [chemical binding]; other site 1110693011938 Predicted transcriptional regulators [Transcription]; Region: COG1733 1110693011939 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1110693011940 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1110693011941 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1110693011942 active site 1110693011943 metal binding site [ion binding]; metal-binding site 1110693011944 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1110693011945 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1110693011946 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1110693011947 active site 1110693011948 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1110693011949 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1110693011950 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1110693011951 Domain of unknown function DUF21; Region: DUF21; pfam01595 1110693011952 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1110693011953 Transporter associated domain; Region: CorC_HlyC; smart01091 1110693011954 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1110693011955 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1110693011956 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1110693011957 Surface antigen; Region: Bac_surface_Ag; pfam01103 1110693011958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1110693011959 Family of unknown function (DUF490); Region: DUF490; pfam04357 1110693011960 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1110693011961 putative active site pocket [active] 1110693011962 dimerization interface [polypeptide binding]; other site 1110693011963 putative catalytic residue [active] 1110693011964 hypothetical protein; Provisional; Region: PRK09719 1110693011965 antitoxin ChpS; Provisional; Region: PRK11347 1110693011966 toxin ChpB; Provisional; Region: PRK09812 1110693011967 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1110693011968 dimer interface [polypeptide binding]; other site 1110693011969 substrate binding site [chemical binding]; other site 1110693011970 metal binding sites [ion binding]; metal-binding site 1110693011971 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1110693011972 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1110693011973 putative ligand binding site [chemical binding]; other site 1110693011974 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1110693011975 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1110693011976 Walker A/P-loop; other site 1110693011977 ATP binding site [chemical binding]; other site 1110693011978 Q-loop/lid; other site 1110693011979 ABC transporter signature motif; other site 1110693011980 Walker B; other site 1110693011981 D-loop; other site 1110693011982 H-loop/switch region; other site 1110693011983 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1110693011984 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1110693011985 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1110693011986 TM-ABC transporter signature motif; other site 1110693011987 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1110693011988 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1110693011989 TM-ABC transporter signature motif; other site 1110693011990 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1110693011991 AMP binding site [chemical binding]; other site 1110693011992 metal binding site [ion binding]; metal-binding site 1110693011993 active site 1110693011994 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1110693011995 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1110693011996 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1110693011997 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1110693011998 hypothetical protein; Provisional; Region: PRK05255 1110693011999 peptidase PmbA; Provisional; Region: PRK11040 1110693012000 cytochrome b562, truncated (pseudogene) 1110693012001 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1110693012002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693012003 FeS/SAM binding site; other site 1110693012004 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1110693012005 ATP cone domain; Region: ATP-cone; pfam03477 1110693012006 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1110693012007 effector binding site; other site 1110693012008 active site 1110693012009 Zn binding site [ion binding]; other site 1110693012010 glycine loop; other site 1110693012011 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1110693012012 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1110693012013 Ca binding site [ion binding]; other site 1110693012014 active site 1110693012015 catalytic site [active] 1110693012016 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1110693012017 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1110693012018 active site turn [active] 1110693012019 phosphorylation site [posttranslational modification] 1110693012020 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1110693012021 trehalose repressor; Provisional; Region: treR; PRK09492 1110693012022 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693012023 DNA binding site [nucleotide binding] 1110693012024 domain linker motif; other site 1110693012025 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1110693012026 dimerization interface [polypeptide binding]; other site 1110693012027 ligand binding site [chemical binding]; other site 1110693012028 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1110693012029 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1110693012030 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1110693012031 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1110693012032 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693012033 motif II; other site 1110693012034 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1110693012035 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1110693012036 homotrimer interaction site [polypeptide binding]; other site 1110693012037 putative active site [active] 1110693012038 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1110693012039 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1110693012040 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1110693012041 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 1110693012042 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1110693012043 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1110693012044 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 1110693012045 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1110693012046 homotrimer interaction site [polypeptide binding]; other site 1110693012047 putative active site [active] 1110693012048 oxidoreductase; Provisional; Region: PRK12742 1110693012049 classical (c) SDRs; Region: SDR_c; cd05233 1110693012050 NAD(P) binding site [chemical binding]; other site 1110693012051 active site 1110693012052 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1110693012053 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1110693012054 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1110693012055 SopA-like central domain; Region: SopA; pfam13981 1110693012056 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1110693012057 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1110693012058 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1110693012059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 1110693012060 RNase E inhibitor protein; Provisional; Region: PRK11191 1110693012061 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1110693012062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1110693012063 Coenzyme A binding pocket [chemical binding]; other site 1110693012064 Predicted membrane protein [Function unknown]; Region: COG4269 1110693012065 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1110693012066 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1110693012067 HIGH motif; other site 1110693012068 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1110693012069 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1110693012070 active site 1110693012071 KMSKS motif; other site 1110693012072 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1110693012073 tRNA binding surface [nucleotide binding]; other site 1110693012074 anticodon binding site; other site 1110693012075 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1110693012076 DNA polymerase III subunit chi; Validated; Region: PRK05728 1110693012077 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1110693012078 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1110693012079 interface (dimer of trimers) [polypeptide binding]; other site 1110693012080 Substrate-binding/catalytic site; other site 1110693012081 Zn-binding sites [ion binding]; other site 1110693012082 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1110693012083 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1110693012084 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1110693012085 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1110693012086 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1110693012087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1110693012088 Walker A motif; other site 1110693012089 ATP binding site [chemical binding]; other site 1110693012090 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1110693012091 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1110693012092 DNA binding site [nucleotide binding] 1110693012093 domain linker motif; other site 1110693012094 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1110693012095 putative dimerization interface [polypeptide binding]; other site 1110693012096 putative ligand binding site [chemical binding]; other site 1110693012097 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1110693012098 gluconate transporter; Region: gntP; TIGR00791 1110693012099 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1110693012100 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1110693012101 NADP binding site [chemical binding]; other site 1110693012102 homodimer interface [polypeptide binding]; other site 1110693012103 active site 1110693012104 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1110693012105 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1110693012106 putative NAD(P) binding site [chemical binding]; other site 1110693012107 catalytic Zn binding site [ion binding]; other site 1110693012108 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1110693012109 ATP-binding site [chemical binding]; other site 1110693012110 Gluconate-6-phosphate binding site [chemical binding]; other site 1110693012111 Shikimate kinase; Region: SKI; pfam01202 1110693012112 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1110693012113 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1110693012114 putative NAD(P) binding site [chemical binding]; other site 1110693012115 putative substrate binding site [chemical binding]; other site 1110693012116 catalytic Zn binding site [ion binding]; other site 1110693012117 structural Zn binding site [ion binding]; other site 1110693012118 dimer interface [polypeptide binding]; other site 1110693012119 fructuronate transporter; Provisional; Region: PRK10034 1110693012120 gluconate transporter; Region: gntP; TIGR00791 1110693012121 mannonate dehydratase; Region: uxuA; TIGR00695 1110693012122 mannonate dehydratase; Provisional; Region: PRK03906 1110693012123 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1110693012124 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1110693012125 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1110693012126 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1110693012127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1110693012128 DNA-binding site [nucleotide binding]; DNA binding site 1110693012129 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1110693012130 phosphoglycerol transferase I; Provisional; Region: PRK03776 1110693012131 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1110693012132 hypothetical protein; Provisional; Region: PRK11667 1110693012133 DNA replication protein DnaC; Validated; Region: PRK07952 1110693012134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1110693012135 Walker A motif; other site 1110693012136 ATP binding site [chemical binding]; other site 1110693012137 Walker B motif; other site 1110693012138 primosomal protein DnaI; Provisional; Region: PRK02854 1110693012139 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1110693012140 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1110693012141 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1110693012142 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1110693012143 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693012144 DNA binding residues [nucleotide binding] 1110693012145 dimerization interface [polypeptide binding]; other site 1110693012146 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1110693012147 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1110693012148 DNA binding residues [nucleotide binding] 1110693012149 dimerization interface [polypeptide binding]; other site 1110693012150 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1110693012151 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1110693012152 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1110693012153 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1110693012154 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1110693012155 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1110693012156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1110693012157 S-adenosylmethionine binding site [chemical binding]; other site 1110693012158 DNA polymerase III subunit psi; Validated; Region: PRK06856 1110693012159 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1110693012160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1110693012161 Coenzyme A binding pocket [chemical binding]; other site 1110693012162 dUMP phosphatase; Provisional; Region: PRK09449 1110693012163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693012164 motif II; other site 1110693012165 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1110693012166 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1110693012167 G1 box; other site 1110693012168 putative GEF interaction site [polypeptide binding]; other site 1110693012169 GTP/Mg2+ binding site [chemical binding]; other site 1110693012170 Switch I region; other site 1110693012171 G2 box; other site 1110693012172 G3 box; other site 1110693012173 Switch II region; other site 1110693012174 G4 box; other site 1110693012175 G5 box; other site 1110693012176 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1110693012177 periplasmic protein; Provisional; Region: PRK10568 1110693012178 BON domain; Region: BON; pfam04972 1110693012179 BON domain; Region: BON; pfam04972 1110693012180 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1110693012181 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1110693012182 active site 1110693012183 nucleophile elbow; other site 1110693012184 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1110693012185 active site 1110693012186 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1110693012187 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1110693012188 FeS/SAM binding site; other site 1110693012189 hypothetical protein; Provisional; Region: PRK10977 1110693012190 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1110693012191 intersubunit interface [polypeptide binding]; other site 1110693012192 active site 1110693012193 catalytic residue [active] 1110693012194 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1110693012195 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1110693012196 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1110693012197 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1110693012198 phosphopentomutase; Provisional; Region: PRK05362 1110693012199 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1110693012200 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1110693012201 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1110693012202 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 1110693012203 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1110693012204 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1110693012205 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1110693012206 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1110693012207 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1110693012208 hypothetical protein; Provisional; Region: PRK11246 1110693012209 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1110693012210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1110693012211 motif II; other site 1110693012212 DNA repair protein RadA; Region: sms; TIGR00416 1110693012213 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1110693012214 Walker A motif/ATP binding site; other site 1110693012215 ATP binding site [chemical binding]; other site 1110693012216 Walker B motif; other site 1110693012217 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1110693012218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1110693012219 non-specific DNA binding site [nucleotide binding]; other site 1110693012220 salt bridge; other site 1110693012221 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1110693012222 sequence-specific DNA binding site [nucleotide binding]; other site 1110693012223 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1110693012224 active site 1110693012225 (T/H)XGH motif; other site 1110693012226 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1110693012227 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1110693012228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1110693012229 Walker A/P-loop; other site 1110693012230 ATP binding site [chemical binding]; other site 1110693012231 Q-loop/lid; other site 1110693012232 ABC transporter signature motif; other site 1110693012233 Walker B; other site 1110693012234 D-loop; other site 1110693012235 H-loop/switch region; other site 1110693012236 ABC transporter; Region: ABC_tran_2; pfam12848 1110693012237 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1110693012238 lytic murein transglycosylase; Provisional; Region: PRK11619 1110693012239 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1110693012240 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1110693012241 catalytic residue [active] 1110693012242 Trp operon repressor; Provisional; Region: PRK01381 1110693012243 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1110693012244 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1110693012245 catalytic core [active] 1110693012246 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1110693012247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1110693012248 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1110693012249 hypothetical protein; Provisional; Region: PRK10756 1110693012250 CreA protein; Region: CreA; pfam05981 1110693012251 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1110693012252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693012253 active site 1110693012254 phosphorylation site [posttranslational modification] 1110693012255 intermolecular recognition site; other site 1110693012256 dimerization interface [polypeptide binding]; other site 1110693012257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693012258 DNA binding site [nucleotide binding] 1110693012259 sensory histidine kinase CreC; Provisional; Region: PRK11100 1110693012260 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1110693012261 dimerization interface [polypeptide binding]; other site 1110693012262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1110693012263 dimer interface [polypeptide binding]; other site 1110693012264 phosphorylation site [posttranslational modification] 1110693012265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1110693012266 ATP binding site [chemical binding]; other site 1110693012267 Mg2+ binding site [ion binding]; other site 1110693012268 G-X-G motif; other site 1110693012269 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 1110693012270 two-component response regulator; Provisional; Region: PRK11173 1110693012271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1110693012272 active site 1110693012273 phosphorylation site [posttranslational modification] 1110693012274 intermolecular recognition site; other site 1110693012275 dimerization interface [polypeptide binding]; other site 1110693012276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1110693012277 DNA binding site [nucleotide binding] 1110693012278 putative RNA methyltransferase; Provisional; Region: PRK10433 1110693012279 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050