-- dump date   	20140619_083119
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
591946000001	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
591946000002	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
591946000003	putative catalytic residues [active]
591946000004	putative nucleotide binding site [chemical binding]; other site
591946000005	putative aspartate binding site [chemical binding]; other site
591946000006	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
591946000007	dimer interface [polypeptide binding]; other site
591946000008	putative threonine allosteric regulatory site; other site
591946000009	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
591946000010	putative threonine allosteric regulatory site; other site
591946000011	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
591946000012	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
591946000013	homoserine kinase; Region: thrB; TIGR00191
591946000014	Protein of unknown function; Region: YhfT; pfam10797
591946000015	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
591946000016	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
591946000017	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
591946000018	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946000019	catalytic residue [active]
591946000020	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
591946000021	hypothetical protein; Validated; Region: PRK02101
591946000022	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
591946000023	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
591946000024	transaldolase-like protein; Provisional; Region: PTZ00411
591946000025	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
591946000026	active site
591946000027	dimer interface [polypeptide binding]; other site
591946000028	catalytic residue [active]
591946000029	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
591946000030	MPT binding site; other site
591946000031	trimer interface [polypeptide binding]; other site
591946000032	hypothetical protein; Provisional; Region: PRK10659
591946000033	hypothetical protein; Provisional; Region: PRK10236
591946000034	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
591946000035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
591946000036	hypothetical protein; Provisional; Region: PRK10154
591946000037	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
591946000038	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
591946000039	nucleotide binding site [chemical binding]; other site
591946000040	NEF interaction site [polypeptide binding]; other site
591946000041	SBD interface [polypeptide binding]; other site
591946000042	chaperone protein DnaJ; Provisional; Region: PRK10767
591946000043	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
591946000044	HSP70 interaction site [polypeptide binding]; other site
591946000045	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
591946000046	substrate binding site [polypeptide binding]; other site
591946000047	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
591946000048	Zn binding sites [ion binding]; other site
591946000049	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
591946000050	dimer interface [polypeptide binding]; other site
591946000051	Hok/gef family; Region: HOK_GEF; pfam01848
591946000052	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
591946000053	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
591946000054	Sulfatase; Region: Sulfatase; pfam00884
591946000055	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
591946000056	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
591946000057	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946000058	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
591946000059	putative dimerization interface [polypeptide binding]; other site
591946000060	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
591946000061	Protein of unknown function (DUF2575); Region: DUF2575; pfam10837
591946000062	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
591946000063	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
591946000064	active site
591946000065	Riboflavin kinase; Region: Flavokinase; smart00904
591946000066	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
591946000067	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
591946000068	HIGH motif; other site
591946000069	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
591946000070	active site
591946000071	KMSKS motif; other site
591946000072	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
591946000073	tRNA binding surface [nucleotide binding]; other site
591946000074	anticodon binding site; other site
591946000075	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
591946000076	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
591946000077	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
591946000078	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
591946000079	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
591946000080	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
591946000081	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
591946000082	active site
591946000083	tetramer interface [polypeptide binding]; other site
591946000084	Protein of unknown function (DUF805); Region: DUF805; pfam05656
591946000085	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
591946000086	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
591946000087	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
591946000088	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
591946000089	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
591946000090	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
591946000091	catalytic site [active]
591946000092	subunit interface [polypeptide binding]; other site
591946000093	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
591946000094	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
591946000095	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
591946000096	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
591946000097	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
591946000098	ATP-grasp domain; Region: ATP-grasp_4; cl17255
591946000099	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
591946000100	IMP binding site; other site
591946000101	dimer interface [polypeptide binding]; other site
591946000102	interdomain contacts; other site
591946000103	partial ornithine binding site; other site
591946000104	DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476
591946000105	carnitine operon protein CaiE; Provisional; Region: PRK13627
591946000106	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
591946000107	putative trimer interface [polypeptide binding]; other site
591946000108	putative metal binding site [ion binding]; other site
591946000109	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
591946000110	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
591946000111	substrate binding site [chemical binding]; other site
591946000112	oxyanion hole (OAH) forming residues; other site
591946000113	trimer interface [polypeptide binding]; other site
591946000114	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
591946000115	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
591946000116	acyl-activating enzyme (AAE) consensus motif; other site
591946000117	putative AMP binding site [chemical binding]; other site
591946000118	putative active site [active]
591946000119	putative CoA binding site [chemical binding]; other site
591946000120	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
591946000121	CoA-transferase family III; Region: CoA_transf_3; pfam02515
591946000122	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
591946000123	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
591946000124	active site
591946000125	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
591946000126	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
591946000127	Ligand binding site [chemical binding]; other site
591946000128	Electron transfer flavoprotein domain; Region: ETF; pfam01012
591946000129	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
591946000130	Electron transfer flavoprotein domain; Region: ETF; smart00893
591946000131	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
591946000132	putative oxidoreductase FixC; Provisional; Region: PRK10157
591946000133	ferredoxin-like protein FixX; Provisional; Region: PRK15449
591946000134	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946000135	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
591946000136	putative substrate translocation pore; other site
591946000137	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
591946000138	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
591946000139	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
591946000140	TrkA-N domain; Region: TrkA_N; pfam02254
591946000141	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
591946000142	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
591946000143	folate binding site [chemical binding]; other site
591946000144	NADP+ binding site [chemical binding]; other site
591946000145	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
591946000146	CcdB protein; Region: CcdB; pfam01845
591946000147	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
591946000148	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
591946000149	active site
591946000150	metal binding site [ion binding]; metal-binding site
591946000151	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
591946000152	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
591946000153	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
591946000154	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
591946000155	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
591946000156	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
591946000157	SurA N-terminal domain; Region: SurA_N; pfam09312
591946000158	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
591946000159	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
591946000160	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
591946000161	OstA-like protein; Region: OstA; pfam03968
591946000162	Organic solvent tolerance protein; Region: OstA_C; pfam04453
591946000163	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
591946000164	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
591946000165	putative metal binding site [ion binding]; other site
591946000166	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
591946000167	HSP70 interaction site [polypeptide binding]; other site
591946000168	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
591946000169	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
591946000170	active site
591946000171	ATP-dependent helicase HepA; Validated; Region: PRK04914
591946000172	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591946000173	ATP binding site [chemical binding]; other site
591946000174	putative Mg++ binding site [ion binding]; other site
591946000175	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591946000176	nucleotide binding region [chemical binding]; other site
591946000177	ATP-binding site [chemical binding]; other site
591946000178	DNA polymerase II; Reviewed; Region: PRK05762
591946000179	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
591946000180	active site
591946000181	catalytic site [active]
591946000182	substrate binding site [chemical binding]; other site
591946000183	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
591946000184	active site
591946000185	metal-binding site
591946000186	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
591946000187	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
591946000188	intersubunit interface [polypeptide binding]; other site
591946000189	active site
591946000190	Zn2+ binding site [ion binding]; other site
591946000191	L-arabinose isomerase; Provisional; Region: PRK02929
591946000192	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
591946000193	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
591946000194	trimer interface [polypeptide binding]; other site
591946000195	putative substrate binding site [chemical binding]; other site
591946000196	putative metal binding site [ion binding]; other site
591946000197	ribulokinase; Provisional; Region: PRK04123
591946000198	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
591946000199	N- and C-terminal domain interface [polypeptide binding]; other site
591946000200	active site
591946000201	MgATP binding site [chemical binding]; other site
591946000202	catalytic site [active]
591946000203	metal binding site [ion binding]; metal-binding site
591946000204	carbohydrate binding site [chemical binding]; other site
591946000205	homodimer interface [polypeptide binding]; other site
591946000206	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
591946000207	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
591946000208	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946000209	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946000210	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
591946000211	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
591946000212	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
591946000213	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
591946000214	Walker A/P-loop; other site
591946000215	ATP binding site [chemical binding]; other site
591946000216	Q-loop/lid; other site
591946000217	ABC transporter signature motif; other site
591946000218	Walker B; other site
591946000219	D-loop; other site
591946000220	H-loop/switch region; other site
591946000221	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
591946000222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946000223	dimer interface [polypeptide binding]; other site
591946000224	conserved gate region; other site
591946000225	putative PBP binding loops; other site
591946000226	ABC-ATPase subunit interface; other site
591946000227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946000228	dimer interface [polypeptide binding]; other site
591946000229	conserved gate region; other site
591946000230	putative PBP binding loops; other site
591946000231	ABC-ATPase subunit interface; other site
591946000232	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
591946000233	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
591946000234	transcriptional regulator SgrR; Provisional; Region: PRK13626
591946000235	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
591946000236	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
591946000237	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
591946000238	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
591946000239	substrate binding site [chemical binding]; other site
591946000240	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
591946000241	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
591946000242	substrate binding site [chemical binding]; other site
591946000243	ligand binding site [chemical binding]; other site
591946000244	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
591946000245	tartrate dehydrogenase; Region: TTC; TIGR02089
591946000246	2-isopropylmalate synthase; Validated; Region: PRK00915
591946000247	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
591946000248	active site
591946000249	catalytic residues [active]
591946000250	metal binding site [ion binding]; metal-binding site
591946000251	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
591946000252	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
591946000253	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946000254	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
591946000255	putative substrate binding pocket [chemical binding]; other site
591946000256	putative dimerization interface [polypeptide binding]; other site
591946000257	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
591946000258	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
591946000259	PYR/PP interface [polypeptide binding]; other site
591946000260	dimer interface [polypeptide binding]; other site
591946000261	TPP binding site [chemical binding]; other site
591946000262	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591946000263	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
591946000264	TPP-binding site [chemical binding]; other site
591946000265	dimer interface [polypeptide binding]; other site
591946000266	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
591946000267	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
591946000268	putative valine binding site [chemical binding]; other site
591946000269	dimer interface [polypeptide binding]; other site
591946000270	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
591946000271	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
591946000272	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946000273	DNA binding site [nucleotide binding]
591946000274	domain linker motif; other site
591946000275	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
591946000276	dimerization interface [polypeptide binding]; other site
591946000277	ligand binding site [chemical binding]; other site
591946000278	mraZ protein; Region: TIGR00242
591946000279	MraZ protein; Region: MraZ; pfam02381
591946000280	MraZ protein; Region: MraZ; pfam02381
591946000281	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
591946000282	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
591946000283	cell division protein FtsL; Provisional; Region: PRK10772
591946000284	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
591946000285	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
591946000286	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
591946000287	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
591946000288	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
591946000289	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591946000290	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591946000291	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
591946000292	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
591946000293	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591946000294	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591946000295	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
591946000296	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
591946000297	Mg++ binding site [ion binding]; other site
591946000298	putative catalytic motif [active]
591946000299	putative substrate binding site [chemical binding]; other site
591946000300	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
591946000301	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591946000302	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591946000303	cell division protein FtsW; Provisional; Region: PRK10774
591946000304	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
591946000305	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
591946000306	active site
591946000307	homodimer interface [polypeptide binding]; other site
591946000308	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
591946000309	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
591946000310	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591946000311	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591946000312	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
591946000313	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
591946000314	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
591946000315	cell division protein FtsQ; Provisional; Region: PRK10775
591946000316	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
591946000317	Cell division protein FtsQ; Region: FtsQ; pfam03799
591946000318	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
591946000319	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591946000320	Cell division protein FtsA; Region: FtsA; pfam14450
591946000321	cell division protein FtsZ; Validated; Region: PRK09330
591946000322	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
591946000323	nucleotide binding site [chemical binding]; other site
591946000324	SulA interaction site; other site
591946000325	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
591946000326	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
591946000327	SecA regulator SecM; Provisional; Region: PRK02943
591946000328	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
591946000329	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
591946000330	SEC-C motif; Region: SEC-C; pfam02810
591946000331	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
591946000332	active site
591946000333	8-oxo-dGMP binding site [chemical binding]; other site
591946000334	nudix motif; other site
591946000335	metal binding site [ion binding]; metal-binding site
591946000336	DNA gyrase inhibitor; Reviewed; Region: PRK00418
591946000337	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582
591946000338	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
591946000339	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
591946000340	CoA-binding site [chemical binding]; other site
591946000341	ATP-binding [chemical binding]; other site
591946000342	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
591946000343	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
591946000344	active site
591946000345	type IV pilin biogenesis protein; Provisional; Region: PRK10573
591946000346	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
591946000347	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
591946000348	hypothetical protein; Provisional; Region: PRK10436
591946000349	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
591946000350	Walker A motif; other site
591946000351	ATP binding site [chemical binding]; other site
591946000352	Walker B motif; other site
591946000353	putative major pilin subunit; Provisional; Region: PRK10574
591946000354	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
591946000355	Pilin (bacterial filament); Region: Pilin; pfam00114
591946000356	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
591946000357	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
591946000358	dimerization interface [polypeptide binding]; other site
591946000359	active site
591946000360	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
591946000361	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
591946000362	amidase catalytic site [active]
591946000363	Zn binding residues [ion binding]; other site
591946000364	substrate binding site [chemical binding]; other site
591946000365	regulatory protein AmpE; Provisional; Region: PRK10987
591946000366	aromatic amino acid transporter; Provisional; Region: PRK10238
591946000367	Protein of unknown function (DUF796); Region: DUF796; cl01226
591946000368	S-type Pyocin; Region: Pyocin_S; pfam06958
591946000369	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
591946000370	active site
591946000371	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
591946000372	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
591946000373	active site
591946000374	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
591946000375	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
591946000376	Transcriptional regulators [Transcription]; Region: FadR; COG2186
591946000377	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946000378	DNA-binding site [nucleotide binding]; DNA binding site
591946000379	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591946000380	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
591946000381	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
591946000382	dimer interface [polypeptide binding]; other site
591946000383	TPP-binding site [chemical binding]; other site
591946000384	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
591946000385	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
591946000386	E3 interaction surface; other site
591946000387	lipoyl attachment site [posttranslational modification]; other site
591946000388	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
591946000389	E3 interaction surface; other site
591946000390	lipoyl attachment site [posttranslational modification]; other site
591946000391	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
591946000392	E3 interaction surface; other site
591946000393	lipoyl attachment site [posttranslational modification]; other site
591946000394	e3 binding domain; Region: E3_binding; pfam02817
591946000395	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
591946000396	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
591946000397	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
591946000398	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946000399	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
591946000400	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
591946000401	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
591946000402	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
591946000403	substrate binding site [chemical binding]; other site
591946000404	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
591946000405	substrate binding site [chemical binding]; other site
591946000406	ligand binding site [chemical binding]; other site
591946000407	hypothetical protein; Provisional; Region: PRK05248
591946000408	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
591946000409	spermidine synthase; Provisional; Region: PRK00811
591946000410	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946000411	S-adenosylmethionine binding site [chemical binding]; other site
591946000412	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
591946000413	multicopper oxidase; Provisional; Region: PRK10965
591946000414	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
591946000415	Multicopper oxidase; Region: Cu-oxidase; pfam00394
591946000416	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
591946000417	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
591946000418	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
591946000419	Trp docking motif [polypeptide binding]; other site
591946000420	putative active site [active]
591946000421	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591946000422	active site
591946000423	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
591946000424	active site clefts [active]
591946000425	zinc binding site [ion binding]; other site
591946000426	dimer interface [polypeptide binding]; other site
591946000427	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
591946000428	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591946000429	Walker A/P-loop; other site
591946000430	ATP binding site [chemical binding]; other site
591946000431	Q-loop/lid; other site
591946000432	ABC transporter signature motif; other site
591946000433	Walker B; other site
591946000434	D-loop; other site
591946000435	H-loop/switch region; other site
591946000436	inner membrane transport permease; Provisional; Region: PRK15066
591946000437	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
591946000438	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
591946000439	active pocket/dimerization site; other site
591946000440	active site
591946000441	phosphorylation site [posttranslational modification]
591946000442	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
591946000443	putative active site [active]
591946000444	putative metal binding site [ion binding]; other site
591946000445	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
591946000446	tetramerization interface [polypeptide binding]; other site
591946000447	active site
591946000448	Uncharacterized conserved protein [Function unknown]; Region: COG5464
591946000449	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
591946000450	pantoate--beta-alanine ligase; Region: panC; TIGR00018
591946000451	Pantoate-beta-alanine ligase; Region: PanC; cd00560
591946000452	active site
591946000453	ATP-binding site [chemical binding]; other site
591946000454	pantoate-binding site; other site
591946000455	HXXH motif; other site
591946000456	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
591946000457	oligomerization interface [polypeptide binding]; other site
591946000458	active site
591946000459	metal binding site [ion binding]; metal-binding site
591946000460	putative fimbrial-like adhesin protein; Provisional; Region: PRK09723
591946000461	putative fimbrial protein StaF; Provisional; Region: PRK15262
591946000462	putative fimbrial protein StaE; Provisional; Region: PRK15263
591946000463	Fimbrial protein; Region: Fimbrial; cl01416
591946000464	putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828
591946000465	PapC N-terminal domain; Region: PapC_N; pfam13954
591946000466	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591946000467	PapC C-terminal domain; Region: PapC_C; pfam13953
591946000468	putative chaperone protein EcpD; Provisional; Region: PRK09926
591946000469	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591946000470	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591946000471	Fimbrial protein; Region: Fimbrial; cl01416
591946000472	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
591946000473	catalytic center binding site [active]
591946000474	ATP binding site [chemical binding]; other site
591946000475	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
591946000476	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
591946000477	active site
591946000478	NTP binding site [chemical binding]; other site
591946000479	metal binding triad [ion binding]; metal-binding site
591946000480	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
591946000481	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
591946000482	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
591946000483	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
591946000484	active site
591946000485	nucleotide binding site [chemical binding]; other site
591946000486	HIGH motif; other site
591946000487	KMSKS motif; other site
591946000488	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
591946000489	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
591946000490	2'-5' RNA ligase; Provisional; Region: PRK15124
591946000491	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
591946000492	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
591946000493	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
591946000494	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591946000495	ATP binding site [chemical binding]; other site
591946000496	putative Mg++ binding site [ion binding]; other site
591946000497	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591946000498	nucleotide binding region [chemical binding]; other site
591946000499	ATP-binding site [chemical binding]; other site
591946000500	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
591946000501	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
591946000502	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
591946000503	Transglycosylase; Region: Transgly; pfam00912
591946000504	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
591946000505	Ferrichrome-iron receptor
591946000506	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
591946000507	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
591946000508	Walker A/P-loop; other site
591946000509	ATP binding site [chemical binding]; other site
591946000510	Q-loop/lid; other site
591946000511	ABC transporter signature motif; other site
591946000512	Walker B; other site
591946000513	D-loop; other site
591946000514	H-loop/switch region; other site
591946000515	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
591946000516	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
591946000517	siderophore binding site; other site
591946000518	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
591946000519	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591946000520	ABC-ATPase subunit  interface; other site
591946000521	dimer interface [polypeptide binding]; other site
591946000522	putative PBP binding regions; other site
591946000523	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591946000524	ABC-ATPase subunit  interface; other site
591946000525	dimer interface [polypeptide binding]; other site
591946000526	putative PBP binding regions; other site
591946000527	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
591946000528	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
591946000529	inhibitor-cofactor binding pocket; inhibition site
591946000530	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946000531	catalytic residue [active]
591946000532	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
591946000533	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
591946000534	Cl- selectivity filter; other site
591946000535	Cl- binding residues [ion binding]; other site
591946000536	pore gating glutamate residue; other site
591946000537	dimer interface [polypeptide binding]; other site
591946000538	H+/Cl- coupling transport residue; other site
591946000539	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
591946000540	hypothetical protein; Provisional; Region: PRK10578
591946000541	UPF0126 domain; Region: UPF0126; pfam03458
591946000542	UPF0126 domain; Region: UPF0126; pfam03458
591946000543	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
591946000544	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
591946000545	cobalamin binding residues [chemical binding]; other site
591946000546	putative BtuC binding residues; other site
591946000547	dimer interface [polypeptide binding]; other site
591946000548	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
591946000549	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
591946000550	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
591946000551	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591946000552	Zn2+ binding site [ion binding]; other site
591946000553	Mg2+ binding site [ion binding]; other site
591946000554	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
591946000555	serine endoprotease; Provisional; Region: PRK10942
591946000556	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
591946000557	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
591946000558	protein binding site [polypeptide binding]; other site
591946000559	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
591946000560	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
591946000561	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
591946000562	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
591946000563	hypothetical protein; Provisional; Region: PRK13677
591946000564	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
591946000565	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
591946000566	trimer interface [polypeptide binding]; other site
591946000567	active site
591946000568	substrate binding site [chemical binding]; other site
591946000569	CoA binding site [chemical binding]; other site
591946000570	PII uridylyl-transferase; Provisional; Region: PRK05007
591946000571	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
591946000572	metal binding triad; other site
591946000573	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
591946000574	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591946000575	Zn2+ binding site [ion binding]; other site
591946000576	Mg2+ binding site [ion binding]; other site
591946000577	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
591946000578	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
591946000579	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
591946000580	active site
591946000581	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
591946000582	rRNA interaction site [nucleotide binding]; other site
591946000583	S8 interaction site; other site
591946000584	putative laminin-1 binding site; other site
591946000585	elongation factor Ts; Provisional; Region: tsf; PRK09377
591946000586	UBA/TS-N domain; Region: UBA; pfam00627
591946000587	Elongation factor TS; Region: EF_TS; pfam00889
591946000588	Elongation factor TS; Region: EF_TS; pfam00889
591946000589	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
591946000590	putative nucleotide binding site [chemical binding]; other site
591946000591	uridine monophosphate binding site [chemical binding]; other site
591946000592	homohexameric interface [polypeptide binding]; other site
591946000593	ribosome recycling factor; Reviewed; Region: frr; PRK00083
591946000594	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
591946000595	hinge region; other site
591946000596	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
591946000597	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
591946000598	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
591946000599	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
591946000600	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
591946000601	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
591946000602	catalytic residue [active]
591946000603	putative FPP diphosphate  binding site; other site
591946000604	putative FPP binding hydrophobic cleft; other site
591946000605	dimer interface [polypeptide binding]; other site
591946000606	putative IPP diphosphate binding site; other site
591946000607	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
591946000608	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
591946000609	zinc metallopeptidase RseP; Provisional; Region: PRK10779
591946000610	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
591946000611	active site
591946000612	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
591946000613	protein binding site [polypeptide binding]; other site
591946000614	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
591946000615	putative substrate binding region [chemical binding]; other site
591946000616	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
591946000617	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
591946000618	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
591946000619	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
591946000620	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
591946000621	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
591946000622	Surface antigen; Region: Bac_surface_Ag; pfam01103
591946000623	periplasmic chaperone; Provisional; Region: PRK10780
591946000624	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
591946000625	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
591946000626	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
591946000627	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
591946000628	trimer interface [polypeptide binding]; other site
591946000629	active site
591946000630	UDP-GlcNAc binding site [chemical binding]; other site
591946000631	lipid binding site [chemical binding]; lipid-binding site
591946000632	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
591946000633	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
591946000634	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
591946000635	active site
591946000636	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
591946000637	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
591946000638	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
591946000639	RNA/DNA hybrid binding site [nucleotide binding]; other site
591946000640	active site
591946000641	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
591946000642	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
591946000643	putative active site [active]
591946000644	putative PHP Thumb interface [polypeptide binding]; other site
591946000645	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
591946000646	generic binding surface II; other site
591946000647	generic binding surface I; other site
591946000648	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
591946000649	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
591946000650	lysine decarboxylase LdcC; Provisional; Region: PRK15399
591946000651	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
591946000652	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
591946000653	homodimer interface [polypeptide binding]; other site
591946000654	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946000655	catalytic residue [active]
591946000656	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
591946000657	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
591946000658	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
591946000659	putative metal binding site [ion binding]; other site
591946000660	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
591946000661	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
591946000662	Ligand Binding Site [chemical binding]; other site
591946000663	TilS substrate binding domain; Region: TilS; pfam09179
591946000664	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
591946000665	Rho-binding antiterminator; Provisional; Region: PRK11625
591946000666	hypothetical protein; Provisional; Region: PRK04964
591946000667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
591946000668	hypothetical protein; Provisional; Region: PRK09256
591946000669	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
591946000670	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
591946000671	NlpE N-terminal domain; Region: NlpE; pfam04170
591946000672	hypothetical protein; Provisional; Region: PRK11479
591946000673	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
591946000674	prolyl-tRNA synthetase; Provisional; Region: PRK09194
591946000675	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
591946000676	dimer interface [polypeptide binding]; other site
591946000677	motif 1; other site
591946000678	active site
591946000679	motif 2; other site
591946000680	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
591946000681	putative deacylase active site [active]
591946000682	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
591946000683	active site
591946000684	motif 3; other site
591946000685	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
591946000686	anticodon binding site; other site
591946000687	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
591946000688	homodimer interaction site [polypeptide binding]; other site
591946000689	cofactor binding site; other site
591946000690	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
591946000691	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
591946000692	lipoprotein, YaeC family; Region: TIGR00363
591946000693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946000694	dimer interface [polypeptide binding]; other site
591946000695	conserved gate region; other site
591946000696	ABC-ATPase subunit interface; other site
591946000697	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
591946000698	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
591946000699	Walker A/P-loop; other site
591946000700	ATP binding site [chemical binding]; other site
591946000701	Q-loop/lid; other site
591946000702	ABC transporter signature motif; other site
591946000703	Walker B; other site
591946000704	D-loop; other site
591946000705	H-loop/switch region; other site
591946000706	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
591946000707	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
591946000708	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946000709	active site
591946000710	motif I; other site
591946000711	motif II; other site
591946000712	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591946000713	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591946000714	active site
591946000715	catalytic tetrad [active]
591946000716	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591946000717	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946000718	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
591946000719	putative effector binding pocket; other site
591946000720	dimerization interface [polypeptide binding]; other site
591946000721	hypothetical protein; Provisional; Region: PRK05421
591946000722	putative catalytic site [active]
591946000723	putative metal binding site [ion binding]; other site
591946000724	putative phosphate binding site [ion binding]; other site
591946000725	putative catalytic site [active]
591946000726	putative phosphate binding site [ion binding]; other site
591946000727	putative metal binding site [ion binding]; other site
591946000728	Methyltransferase domain; Region: Methyltransf_23; pfam13489
591946000729	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946000730	S-adenosylmethionine binding site [chemical binding]; other site
591946000731	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
591946000732	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591946000733	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591946000734	catalytic residue [active]
591946000735	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591946000736	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591946000737	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
591946000738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946000739	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
591946000740	RNA/DNA hybrid binding site [nucleotide binding]; other site
591946000741	active site
591946000742	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
591946000743	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
591946000744	active site
591946000745	catalytic site [active]
591946000746	substrate binding site [chemical binding]; other site
591946000747	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
591946000748	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
591946000749	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
591946000750	ImpA domain protein; Region: DUF3702; pfam12486
591946000751	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
591946000752	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
591946000753	G1 box; other site
591946000754	GTP/Mg2+ binding site [chemical binding]; other site
591946000755	G2 box; other site
591946000756	Switch I region; other site
591946000757	G3 box; other site
591946000758	Switch II region; other site
591946000759	G4 box; other site
591946000760	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
591946000761	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
591946000762	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
591946000763	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
591946000764	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
591946000765	type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360
591946000766	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
591946000767	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946000768	Walker A motif; other site
591946000769	ATP binding site [chemical binding]; other site
591946000770	Walker B motif; other site
591946000771	arginine finger; other site
591946000772	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946000773	Walker A motif; other site
591946000774	ATP binding site [chemical binding]; other site
591946000775	Walker B motif; other site
591946000776	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
591946000777	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
591946000778	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
591946000779	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
591946000780	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
591946000781	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
591946000782	FHA domain; Region: FHA; pfam00498
591946000783	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
591946000784	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
591946000785	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
591946000786	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
591946000787	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
591946000788	Protein of unknown function (DUF877); Region: DUF877; pfam05943
591946000789	Protein of unknown function (DUF770); Region: DUF770; pfam05591
591946000790	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
591946000791	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
591946000792	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
591946000793	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
591946000794	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
591946000795	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
591946000796	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
591946000797	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591946000798	Transposase [DNA replication, recombination, and repair]; Region: COG5433
591946000799	PAAR motif; Region: PAAR_motif; pfam05488
591946000800	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
591946000801	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
591946000802	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
591946000803	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
591946000804	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
591946000805	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
591946000806	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
591946000807	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
591946000808	putative active site [active]
591946000809	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
591946000810	Transposase [DNA replication, recombination, and repair]; Region: COG5433
591946000811	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
591946000812	C-N hydrolase family amidase; Provisional; Region: PRK10438
591946000813	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
591946000814	putative active site [active]
591946000815	catalytic triad [active]
591946000816	dimer interface [polypeptide binding]; other site
591946000817	multimer interface [polypeptide binding]; other site
591946000818	C-lysozyme inhibitor; Provisional; Region: PRK09993
591946000819	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
591946000820	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
591946000821	active site
591946000822	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
591946000823	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
591946000824	dimer interface [polypeptide binding]; other site
591946000825	active site
591946000826	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
591946000827	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
591946000828	putative active site [active]
591946000829	putative dimer interface [polypeptide binding]; other site
591946000830	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
591946000831	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591946000832	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
591946000833	NlpC/P60 family; Region: NLPC_P60; pfam00877
591946000834	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
591946000835	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298
591946000836	FHIPEP family; Region: FHIPEP; pfam00771
591946000837	hypothetical protein; Validated; Region: PRK06778
591946000838	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
591946000839	ligand binding site [chemical binding]; other site
591946000840	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
591946000841	active site
591946000842	DNA polymerase IV; Validated; Region: PRK02406
591946000843	DNA binding site [nucleotide binding]
591946000844	putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778
591946000845	putative toxin YafO; Provisional; Region: PRK09885
591946000846	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
591946000847	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946000848	Coenzyme A binding pocket [chemical binding]; other site
591946000849	hypothetical protein; Reviewed; Region: PRK09588
591946000850	release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073
591946000851	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
591946000852	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
591946000853	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
591946000854	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
591946000855	metal binding site [ion binding]; metal-binding site
591946000856	dimer interface [polypeptide binding]; other site
591946000857	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591946000858	active site
591946000859	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
591946000860	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
591946000861	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591946000862	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591946000863	trimer interface [polypeptide binding]; other site
591946000864	eyelet of channel; other site
591946000865	gamma-glutamyl kinase; Provisional; Region: PRK05429
591946000866	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
591946000867	nucleotide binding site [chemical binding]; other site
591946000868	homotetrameric interface [polypeptide binding]; other site
591946000869	putative phosphate binding site [ion binding]; other site
591946000870	putative allosteric binding site; other site
591946000871	PUA domain; Region: PUA; pfam01472
591946000872	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
591946000873	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
591946000874	putative catalytic cysteine [active]
591946000875	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
591946000876	MarR family; Region: MarR_2; cl17246
591946000877	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
591946000878	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
591946000879	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
591946000880	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
591946000881	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
591946000882	Autotransporter beta-domain; Region: Autotransporter; pfam03797
591946000883	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
591946000884	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
591946000885	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
591946000886	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591946000887	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591946000888	Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477
591946000889	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
591946000890	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591946000891	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
591946000892	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
591946000893	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946000894	DNA binding residues [nucleotide binding]
591946000895	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
591946000896	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
591946000897	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
591946000898	putative active site [active]
591946000899	putative FMN binding site [chemical binding]; other site
591946000900	putative substrate binding site [chemical binding]; other site
591946000901	putative catalytic residue [active]
591946000902	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
591946000903	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591946000904	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946000905	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
591946000906	putative effector binding pocket; other site
591946000907	putative dimerization interface [polypeptide binding]; other site
591946000908	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591946000909	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946000910	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
591946000911	putative effector binding pocket; other site
591946000912	putative dimerization interface [polypeptide binding]; other site
591946000913	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591946000914	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591946000915	active site
591946000916	catalytic tetrad [active]
591946000917	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591946000918	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591946000919	active site
591946000920	catalytic tetrad [active]
591946000921	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
591946000922	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
591946000923	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
591946000924	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
591946000925	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
591946000926	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
591946000927	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946000928	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
591946000929	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591946000930	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591946000931	active site
591946000932	catalytic tetrad [active]
591946000933	Predicted membrane protein [Function unknown]; Region: COG3059
591946000934	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591946000935	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
591946000936	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
591946000937	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946000938	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
591946000939	Cupin; Region: Cupin_6; pfam12852
591946000940	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
591946000941	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946000942	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
591946000943	Cysteine-rich domain; Region: CCG; pfam02754
591946000944	Cysteine-rich domain; Region: CCG; pfam02754
591946000945	iron-sulfur cluster-binding protein; Region: TIGR00273
591946000946	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
591946000947	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591946000948	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
591946000949	Uncharacterized conserved protein [Function unknown]; Region: COG1556
591946000950	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
591946000951	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
591946000952	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
591946000953	Autotransporter beta-domain; Region: Autotransporter; pfam03797
591946000954	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
591946000955	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946000956	DNA binding residues [nucleotide binding]
591946000957	dimerization interface [polypeptide binding]; other site
591946000958	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591946000959	active site
591946000960	DNA binding site [nucleotide binding]
591946000961	Int/Topo IB signature motif; other site
591946000962	choline dehydrogenase; Validated; Region: PRK02106
591946000963	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
591946000964	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
591946000965	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
591946000966	tetrameric interface [polypeptide binding]; other site
591946000967	NAD binding site [chemical binding]; other site
591946000968	catalytic residues [active]
591946000969	transcriptional regulator BetI; Validated; Region: PRK00767
591946000970	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591946000971	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
591946000972	choline transport protein BetT; Provisional; Region: PRK09928
591946000973	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946000974	DNA binding residues [nucleotide binding]
591946000975	dimerization interface [polypeptide binding]; other site
591946000976	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946000977	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
591946000978	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946000979	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591946000980	dimerization interface [polypeptide binding]; other site
591946000981	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
591946000982	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
591946000983	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
591946000984	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
591946000985	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
591946000986	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
591946000987	CoA binding domain; Region: CoA_binding; pfam02629
591946000988	CoA-ligase; Region: Ligase_CoA; pfam00549
591946000989	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
591946000990	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
591946000991	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
591946000992	putative substrate binding site [chemical binding]; other site
591946000993	nucleotide binding site [chemical binding]; other site
591946000994	nucleotide binding site [chemical binding]; other site
591946000995	homodimer interface [polypeptide binding]; other site
591946000996	putative deaminase; Validated; Region: PRK06846
591946000997	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
591946000998	active site
591946000999	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
591946001000	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
591946001001	putative NAD(P) binding site [chemical binding]; other site
591946001002	putative substrate binding site [chemical binding]; other site
591946001003	catalytic Zn binding site [ion binding]; other site
591946001004	structural Zn binding site [ion binding]; other site
591946001005	dimer interface [polypeptide binding]; other site
591946001006	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
591946001007	hypothetical protein; Provisional; Region: PRK09929
591946001008	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
591946001009	Propionate catabolism activator; Region: PrpR_N; pfam06506
591946001010	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946001011	Walker A motif; other site
591946001012	ATP binding site [chemical binding]; other site
591946001013	Walker B motif; other site
591946001014	arginine finger; other site
591946001015	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
591946001016	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
591946001017	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
591946001018	tetramer interface [polypeptide binding]; other site
591946001019	active site
591946001020	Mg2+/Mn2+ binding site [ion binding]; other site
591946001021	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
591946001022	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
591946001023	dimer interface [polypeptide binding]; other site
591946001024	active site
591946001025	citrylCoA binding site [chemical binding]; other site
591946001026	oxalacetate/citrate binding site [chemical binding]; other site
591946001027	coenzyme A binding site [chemical binding]; other site
591946001028	catalytic triad [active]
591946001029	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
591946001030	2-methylcitrate dehydratase; Region: prpD; TIGR02330
591946001031	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
591946001032	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
591946001033	acyl-activating enzyme (AAE) consensus motif; other site
591946001034	putative AMP binding site [chemical binding]; other site
591946001035	putative active site [active]
591946001036	putative CoA binding site [chemical binding]; other site
591946001037	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
591946001038	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
591946001039	Na binding site [ion binding]; other site
591946001040	putative substrate binding site [chemical binding]; other site
591946001041	cytosine deaminase; Provisional; Region: PRK09230
591946001042	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
591946001043	active site
591946001044	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
591946001045	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
591946001046	active site
591946001047	substrate binding site [chemical binding]; other site
591946001048	trimer interface [polypeptide binding]; other site
591946001049	CoA binding site [chemical binding]; other site
591946001050	LacY proton/sugar symporter; Region: LacY_symp; pfam01306
591946001051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946001052	putative substrate translocation pore; other site
591946001053	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
591946001054	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
591946001055	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
591946001056	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
591946001057	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
591946001058	lac repressor; Reviewed; Region: lacI; PRK09526
591946001059	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946001060	DNA binding site [nucleotide binding]
591946001061	domain linker motif; other site
591946001062	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
591946001063	ligand binding site [chemical binding]; other site
591946001064	dimerization interface (open form) [polypeptide binding]; other site
591946001065	dimerization interface (closed form) [polypeptide binding]; other site
591946001066	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
591946001067	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
591946001068	S-formylglutathione hydrolase; Region: PLN02442
591946001069	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
591946001070	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
591946001071	substrate binding site [chemical binding]; other site
591946001072	catalytic Zn binding site [ion binding]; other site
591946001073	NAD binding site [chemical binding]; other site
591946001074	structural Zn binding site [ion binding]; other site
591946001075	dimer interface [polypeptide binding]; other site
591946001076	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
591946001077	putative metal binding site [ion binding]; other site
591946001078	putative homodimer interface [polypeptide binding]; other site
591946001079	putative homotetramer interface [polypeptide binding]; other site
591946001080	putative homodimer-homodimer interface [polypeptide binding]; other site
591946001081	putative allosteric switch controlling residues; other site
591946001082	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
591946001083	putative trimer interface [polypeptide binding]; other site
591946001084	putative CoA binding site [chemical binding]; other site
591946001085	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
591946001086	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
591946001087	DXD motif; other site
591946001088	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
591946001089	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
591946001090	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946001091	substrate binding pocket [chemical binding]; other site
591946001092	membrane-bound complex binding site; other site
591946001093	hinge residues; other site
591946001094	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
591946001095	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
591946001096	Walker A/P-loop; other site
591946001097	ATP binding site [chemical binding]; other site
591946001098	Q-loop/lid; other site
591946001099	ABC transporter signature motif; other site
591946001100	Walker B; other site
591946001101	D-loop; other site
591946001102	H-loop/switch region; other site
591946001103	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
591946001104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946001105	dimer interface [polypeptide binding]; other site
591946001106	conserved gate region; other site
591946001107	putative PBP binding loops; other site
591946001108	ABC-ATPase subunit interface; other site
591946001109	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
591946001110	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
591946001111	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
591946001112	dimer interface [polypeptide binding]; other site
591946001113	active site
591946001114	Schiff base residues; other site
591946001115	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
591946001116	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
591946001117	Autotransporter beta-domain; Region: Autotransporter; pfam03797
591946001118	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
591946001119	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
591946001120	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
591946001121	microcin B17 transporter; Reviewed; Region: PRK11098
591946001122	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
591946001123	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
591946001124	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
591946001125	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
591946001126	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
591946001127	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
591946001128	anti-RssB factor; Provisional; Region: PRK10244
591946001129	alkaline phosphatase; Provisional; Region: PRK10518
591946001130	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
591946001131	dimer interface [polypeptide binding]; other site
591946001132	active site
591946001133	hypothetical protein; Provisional; Region: PRK11505
591946001134	psiF repeat; Region: PsiF_repeat; pfam07769
591946001135	psiF repeat; Region: PsiF_repeat; pfam07769
591946001136	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
591946001137	MASE2 domain; Region: MASE2; pfam05230
591946001138	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946001139	metal binding site [ion binding]; metal-binding site
591946001140	active site
591946001141	I-site; other site
591946001142	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
591946001143	pyrroline-5-carboxylate reductase; Region: PLN02688
591946001144	hypothetical protein; Validated; Region: PRK00124
591946001145	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
591946001146	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
591946001147	ADP binding site [chemical binding]; other site
591946001148	magnesium binding site [ion binding]; other site
591946001149	putative shikimate binding site; other site
591946001150	hypothetical protein; Provisional; Region: PRK10380
591946001151	hypothetical protein; Provisional; Region: PRK10481
591946001152	hypothetical protein; Provisional; Region: PRK10579
591946001153	Protein of unknown function (DUF2773); Region: DUF2773; pfam10971
591946001154	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
591946001155	fructokinase; Reviewed; Region: PRK09557
591946001156	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591946001157	nucleotide binding site [chemical binding]; other site
591946001158	MFS transport protein AraJ; Provisional; Region: PRK10091
591946001159	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946001160	putative substrate translocation pore; other site
591946001161	exonuclease subunit SbcC; Provisional; Region: PRK10246
591946001162	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946001163	Walker A/P-loop; other site
591946001164	ATP binding site [chemical binding]; other site
591946001165	Q-loop/lid; other site
591946001166	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946001167	ABC transporter signature motif; other site
591946001168	Walker B; other site
591946001169	D-loop; other site
591946001170	H-loop/switch region; other site
591946001171	exonuclease subunit SbcD; Provisional; Region: PRK10966
591946001172	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
591946001173	active site
591946001174	metal binding site [ion binding]; metal-binding site
591946001175	DNA binding site [nucleotide binding]
591946001176	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
591946001177	transcriptional regulator PhoB; Provisional; Region: PRK10161
591946001178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946001179	active site
591946001180	phosphorylation site [posttranslational modification]
591946001181	intermolecular recognition site; other site
591946001182	dimerization interface [polypeptide binding]; other site
591946001183	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946001184	DNA binding site [nucleotide binding]
591946001185	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
591946001186	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
591946001187	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591946001188	putative active site [active]
591946001189	heme pocket [chemical binding]; other site
591946001190	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946001191	dimer interface [polypeptide binding]; other site
591946001192	phosphorylation site [posttranslational modification]
591946001193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946001194	ATP binding site [chemical binding]; other site
591946001195	Mg2+ binding site [ion binding]; other site
591946001196	G-X-G motif; other site
591946001197	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
591946001198	putative proline-specific permease; Provisional; Region: proY; PRK10580
591946001199	Spore germination protein; Region: Spore_permease; cl17796
591946001200	maltodextrin glucosidase; Provisional; Region: PRK10785
591946001201	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
591946001202	homodimer interface [polypeptide binding]; other site
591946001203	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
591946001204	active site
591946001205	homodimer interface [polypeptide binding]; other site
591946001206	catalytic site [active]
591946001207	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
591946001208	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
591946001209	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
591946001210	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
591946001211	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
591946001212	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
591946001213	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
591946001214	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
591946001215	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
591946001216	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
591946001217	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
591946001218	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
591946001219	Protein export membrane protein; Region: SecD_SecF; pfam02355
591946001220	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
591946001221	active site
591946001222	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
591946001223	hypothetical protein; Provisional; Region: PRK11530
591946001224	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
591946001225	ATP cone domain; Region: ATP-cone; pfam03477
591946001226	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
591946001227	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
591946001228	catalytic motif [active]
591946001229	Zn binding site [ion binding]; other site
591946001230	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
591946001231	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
591946001232	homopentamer interface [polypeptide binding]; other site
591946001233	active site
591946001234	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
591946001235	putative RNA binding site [nucleotide binding]; other site
591946001236	thiamine monophosphate kinase; Provisional; Region: PRK05731
591946001237	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
591946001238	ATP binding site [chemical binding]; other site
591946001239	dimerization interface [polypeptide binding]; other site
591946001240	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
591946001241	tetramer interfaces [polypeptide binding]; other site
591946001242	binuclear metal-binding site [ion binding]; other site
591946001243	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591946001244	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591946001245	active site
591946001246	catalytic tetrad [active]
591946001247	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
591946001248	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
591946001249	TPP-binding site; other site
591946001250	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
591946001251	PYR/PP interface [polypeptide binding]; other site
591946001252	dimer interface [polypeptide binding]; other site
591946001253	TPP binding site [chemical binding]; other site
591946001254	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
591946001255	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
591946001256	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
591946001257	substrate binding pocket [chemical binding]; other site
591946001258	chain length determination region; other site
591946001259	substrate-Mg2+ binding site; other site
591946001260	catalytic residues [active]
591946001261	aspartate-rich region 1; other site
591946001262	active site lid residues [active]
591946001263	aspartate-rich region 2; other site
591946001264	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
591946001265	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
591946001266	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
591946001267	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
591946001268	Ligand Binding Site [chemical binding]; other site
591946001269	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
591946001270	active site residue [active]
591946001271	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
591946001272	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
591946001273	conserved cys residue [active]
591946001274	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
591946001275	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
591946001276	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
591946001277	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
591946001278	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
591946001279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946001280	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591946001281	putative substrate translocation pore; other site
591946001282	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
591946001283	UbiA prenyltransferase family; Region: UbiA; pfam01040
591946001284	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
591946001285	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
591946001286	Subunit I/III interface [polypeptide binding]; other site
591946001287	Subunit III/IV interface [polypeptide binding]; other site
591946001288	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
591946001289	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
591946001290	D-pathway; other site
591946001291	Putative ubiquinol binding site [chemical binding]; other site
591946001292	Low-spin heme (heme b) binding site [chemical binding]; other site
591946001293	Putative water exit pathway; other site
591946001294	Binuclear center (heme o3/CuB) [ion binding]; other site
591946001295	K-pathway; other site
591946001296	Putative proton exit pathway; other site
591946001297	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
591946001298	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
591946001299	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
591946001300	muropeptide transporter; Reviewed; Region: ampG; PRK11902
591946001301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946001302	putative substrate translocation pore; other site
591946001303	hypothetical protein; Provisional; Region: PRK11627
591946001304	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
591946001305	transcriptional regulator BolA; Provisional; Region: PRK11628
591946001306	trigger factor; Provisional; Region: tig; PRK01490
591946001307	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
591946001308	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
591946001309	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
591946001310	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
591946001311	oligomer interface [polypeptide binding]; other site
591946001312	active site residues [active]
591946001313	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
591946001314	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
591946001315	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946001316	Walker A motif; other site
591946001317	ATP binding site [chemical binding]; other site
591946001318	Walker B motif; other site
591946001319	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
591946001320	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
591946001321	Found in ATP-dependent protease La (LON); Region: LON; smart00464
591946001322	Found in ATP-dependent protease La (LON); Region: LON; smart00464
591946001323	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946001324	Walker A motif; other site
591946001325	ATP binding site [chemical binding]; other site
591946001326	Walker B motif; other site
591946001327	arginine finger; other site
591946001328	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
591946001329	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
591946001330	IHF dimer interface [polypeptide binding]; other site
591946001331	IHF - DNA interface [nucleotide binding]; other site
591946001332	periplasmic folding chaperone; Provisional; Region: PRK10788
591946001333	SurA N-terminal domain; Region: SurA_N_3; cl07813
591946001334	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
591946001335	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
591946001336	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
591946001337	active site
591946001338	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
591946001339	Ligand Binding Site [chemical binding]; other site
591946001340	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
591946001341	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
591946001342	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
591946001343	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
591946001344	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946001345	active site
591946001346	motif I; other site
591946001347	motif II; other site
591946001348	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591946001349	dimerization interface [polypeptide binding]; other site
591946001350	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
591946001351	putative DNA binding site [nucleotide binding]; other site
591946001352	putative Zn2+ binding site [ion binding]; other site
591946001353	AsnC family; Region: AsnC_trans_reg; pfam01037
591946001354	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591946001355	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
591946001356	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946001357	Walker A/P-loop; other site
591946001358	ATP binding site [chemical binding]; other site
591946001359	Q-loop/lid; other site
591946001360	ABC transporter signature motif; other site
591946001361	Walker B; other site
591946001362	D-loop; other site
591946001363	H-loop/switch region; other site
591946001364	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
591946001365	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591946001366	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
591946001367	Walker A/P-loop; other site
591946001368	ATP binding site [chemical binding]; other site
591946001369	Q-loop/lid; other site
591946001370	ABC transporter signature motif; other site
591946001371	Walker B; other site
591946001372	D-loop; other site
591946001373	H-loop/switch region; other site
591946001374	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
591946001375	Nitrogen regulatory protein P-II; Region: P-II; smart00938
591946001376	ammonium transporter; Provisional; Region: PRK10666
591946001377	acyl-CoA thioesterase II; Provisional; Region: PRK10526
591946001378	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
591946001379	active site
591946001380	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
591946001381	catalytic triad [active]
591946001382	dimer interface [polypeptide binding]; other site
591946001383	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
591946001384	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
591946001385	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
591946001386	DNA binding site [nucleotide binding]
591946001387	active site
591946001388	Uncharacterized conserved protein [Function unknown]; Region: COG5507
591946001389	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
591946001390	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
591946001391	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946001392	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
591946001393	maltose O-acetyltransferase; Provisional; Region: PRK10092
591946001394	Maltose acetyltransferase; Region: Mac; pfam12464
591946001395	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
591946001396	trimer interface [polypeptide binding]; other site
591946001397	active site
591946001398	substrate binding site [chemical binding]; other site
591946001399	CoA binding site [chemical binding]; other site
591946001400	gene expression modulator; Provisional; Region: PRK10945
591946001401	Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757
591946001402	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
591946001403	Protein export membrane protein; Region: SecD_SecF; cl14618
591946001404	Protein export membrane protein; Region: SecD_SecF; cl14618
591946001405	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
591946001406	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946001407	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946001408	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
591946001409	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591946001410	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
591946001411	hypothetical protein; Provisional; Region: PRK11281
591946001412	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
591946001413	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
591946001414	Mechanosensitive ion channel; Region: MS_channel; pfam00924
591946001415	hypothetical protein; Provisional; Region: PRK11038
591946001416	primosomal replication protein N''; Provisional; Region: PRK10093
591946001417	hypothetical protein; Provisional; Region: PRK10527
591946001418	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591946001419	active site
591946001420	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
591946001421	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946001422	Walker A motif; other site
591946001423	ATP binding site [chemical binding]; other site
591946001424	Walker B motif; other site
591946001425	DNA polymerase III subunit delta'; Validated; Region: PRK08485
591946001426	arginine finger; other site
591946001427	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
591946001428	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
591946001429	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
591946001430	hypothetical protein; Validated; Region: PRK00153
591946001431	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353
591946001432	RecR protein; Region: RecR; pfam02132
591946001433	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
591946001434	putative active site [active]
591946001435	putative metal-binding site [ion binding]; other site
591946001436	tetramer interface [polypeptide binding]; other site
591946001437	heat shock protein 90; Provisional; Region: PRK05218
591946001438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946001439	ATP binding site [chemical binding]; other site
591946001440	Mg2+ binding site [ion binding]; other site
591946001441	G-X-G motif; other site
591946001442	adenylate kinase; Reviewed; Region: adk; PRK00279
591946001443	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
591946001444	AMP-binding site [chemical binding]; other site
591946001445	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
591946001446	ferrochelatase; Region: hemH; TIGR00109
591946001447	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
591946001448	C-terminal domain interface [polypeptide binding]; other site
591946001449	active site
591946001450	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
591946001451	active site
591946001452	N-terminal domain interface [polypeptide binding]; other site
591946001453	acetyl esterase; Provisional; Region: PRK10162
591946001454	inosine/guanosine kinase; Provisional; Region: PRK15074
591946001455	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591946001456	putative cation:proton antiport protein; Provisional; Region: PRK10669
591946001457	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
591946001458	TrkA-N domain; Region: TrkA_N; pfam02254
591946001459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946001460	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591946001461	putative substrate translocation pore; other site
591946001462	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
591946001463	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
591946001464	active site
591946001465	metal binding site [ion binding]; metal-binding site
591946001466	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
591946001467	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
591946001468	putative deacylase active site [active]
591946001469	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
591946001470	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
591946001471	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946001472	non-specific DNA binding site [nucleotide binding]; other site
591946001473	salt bridge; other site
591946001474	sequence-specific DNA binding site [nucleotide binding]; other site
591946001475	copper exporting ATPase; Provisional; Region: copA; PRK10671
591946001476	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
591946001477	metal-binding site [ion binding]
591946001478	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
591946001479	metal-binding site [ion binding]
591946001480	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591946001481	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946001482	motif II; other site
591946001483	glutaminase; Reviewed; Region: PRK12356
591946001484	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
591946001485	amino acid transporter; Region: 2A0306; TIGR00909
591946001486	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
591946001487	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
591946001488	DNA binding residues [nucleotide binding]
591946001489	dimer interface [polypeptide binding]; other site
591946001490	copper binding site [ion binding]; other site
591946001491	corresponding to LF82_p065 in publication : Miquel et al., PLoS One; 536; CFT073; ED1a; HS; IAI1; E2348
591946001492	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
591946001493	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
591946001494	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
591946001495	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
591946001496	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946001497	Walker A/P-loop; other site
591946001498	ATP binding site [chemical binding]; other site
591946001499	Q-loop/lid; other site
591946001500	ABC transporter signature motif; other site
591946001501	Walker B; other site
591946001502	D-loop; other site
591946001503	H-loop/switch region; other site
591946001504	Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649
591946001505	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
591946001506	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
591946001507	oxidoreductase; Provisional; Region: PRK08017
591946001508	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
591946001509	NADP binding site [chemical binding]; other site
591946001510	active site
591946001511	steroid binding site; other site
591946001512	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
591946001513	active site
591946001514	catalytic triad [active]
591946001515	oxyanion hole [active]
591946001516	switch loop; other site
591946001517	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
591946001518	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591946001519	Walker A/P-loop; other site
591946001520	ATP binding site [chemical binding]; other site
591946001521	Q-loop/lid; other site
591946001522	ABC transporter signature motif; other site
591946001523	Walker B; other site
591946001524	D-loop; other site
591946001525	H-loop/switch region; other site
591946001526	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
591946001527	FtsX-like permease family; Region: FtsX; pfam02687
591946001528	FtsX-like permease family; Region: FtsX; pfam02687
591946001529	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
591946001530	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
591946001531	active site residue [active]
591946001532	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
591946001533	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946001534	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591946001535	dimerization interface [polypeptide binding]; other site
591946001536	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
591946001537	ureidoglycolate hydrolase; Provisional; Region: PRK03606
591946001538	DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163
591946001539	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
591946001540	Bacterial transcriptional regulator; Region: IclR; pfam01614
591946001541	glyoxylate carboligase; Provisional; Region: PRK11269
591946001542	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
591946001543	PYR/PP interface [polypeptide binding]; other site
591946001544	dimer interface [polypeptide binding]; other site
591946001545	TPP binding site [chemical binding]; other site
591946001546	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591946001547	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
591946001548	TPP-binding site [chemical binding]; other site
591946001549	hydroxypyruvate isomerase; Provisional; Region: PRK09997
591946001550	tartronate semialdehyde reductase; Provisional; Region: PRK15059
591946001551	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
591946001552	nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323
591946001553	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
591946001554	Na binding site [ion binding]; other site
591946001555	substrate binding site [chemical binding]; other site
591946001556	allantoinase; Provisional; Region: PRK08044
591946001557	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
591946001558	active site
591946001559	putative uracil/xanthine transporter; Provisional; Region: PRK11412
591946001560	glycerate kinase II; Provisional; Region: PRK09932
591946001561	putative allantoin catabolism protein; Region: ura-cupin; TIGR03214
591946001562	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
591946001563	Cupin domain; Region: Cupin_2; cl17218
591946001564	allantoate amidohydrolase; Region: AllC; TIGR03176
591946001565	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
591946001566	active site
591946001567	metal binding site [ion binding]; metal-binding site
591946001568	dimer interface [polypeptide binding]; other site
591946001569	ureidoglycolate dehydrogenase; Provisional; Region: PRK15025
591946001570	membrane protein FdrA; Validated; Region: PRK06091
591946001571	CoA binding domain; Region: CoA_binding; pfam02629
591946001572	CoA-ligase; Region: Ligase_CoA; pfam00549
591946001573	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
591946001574	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
591946001575	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
591946001576	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
591946001577	putative substrate binding site [chemical binding]; other site
591946001578	nucleotide binding site [chemical binding]; other site
591946001579	nucleotide binding site [chemical binding]; other site
591946001580	homodimer interface [polypeptide binding]; other site
591946001581	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
591946001582	ATP-grasp domain; Region: ATP-grasp; pfam02222
591946001583	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
591946001584	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
591946001585	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
591946001586	putative active site [active]
591946001587	putative metal binding site [ion binding]; other site
591946001588	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
591946001589	substrate binding site [chemical binding]; other site
591946001590	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
591946001591	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
591946001592	active site
591946001593	HIGH motif; other site
591946001594	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
591946001595	KMSKS motif; other site
591946001596	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
591946001597	tRNA binding surface [nucleotide binding]; other site
591946001598	anticodon binding site; other site
591946001599	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
591946001600	ribosome-associated protein; Provisional; Region: PRK11507
591946001601	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
591946001602	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
591946001603	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
591946001604	homodimer interface [polypeptide binding]; other site
591946001605	NADP binding site [chemical binding]; other site
591946001606	substrate binding site [chemical binding]; other site
591946001607	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591946001608	DNA binding site [nucleotide binding]
591946001609	active site
591946001610	Int/Topo IB signature motif; other site
591946001611	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591946001612	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
591946001613	Methyltransferase domain; Region: Methyltransf_12; pfam08242
591946001614	S-adenosylmethionine binding site [chemical binding]; other site
591946001615	outer membrane protease; Reviewed; Region: PRK10993
591946001616	hypothetical protein; Provisional; Region: PRK09936
591946001617	bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782
591946001618	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591946001619	TPR motif; other site
591946001620	binding surface
591946001621	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
591946001622	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
591946001623	active site
591946001624	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
591946001625	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
591946001626	sensor kinase CusS; Provisional; Region: PRK09835
591946001627	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591946001628	dimerization interface [polypeptide binding]; other site
591946001629	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946001630	dimer interface [polypeptide binding]; other site
591946001631	phosphorylation site [posttranslational modification]
591946001632	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946001633	ATP binding site [chemical binding]; other site
591946001634	Mg2+ binding site [ion binding]; other site
591946001635	G-X-G motif; other site
591946001636	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
591946001637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946001638	active site
591946001639	phosphorylation site [posttranslational modification]
591946001640	intermolecular recognition site; other site
591946001641	dimerization interface [polypeptide binding]; other site
591946001642	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946001643	DNA binding site [nucleotide binding]
591946001644	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
591946001645	periplasmic copper-binding protein; Provisional; Region: PRK09838
591946001646	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
591946001647	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946001648	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
591946001649	phenylalanine transporter; Provisional; Region: PRK10249
591946001650	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
591946001651	Mechanosensitive ion channel; Region: MS_channel; pfam00924
591946001652	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
591946001653	dimer interface [polypeptide binding]; other site
591946001654	FMN binding site [chemical binding]; other site
591946001655	hypothetical protein; Provisional; Region: PRK10250
591946001656	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
591946001657	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
591946001658	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
591946001659	Hok/gef family; Region: HOK_GEF; pfam01848
591946001660	Hok/gef family; Region: HOK_GEF; pfam01848
591946001661	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
591946001662	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
591946001663	outer membrane receptor FepA; Provisional; Region: PRK13524
591946001664	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591946001665	N-terminal plug; other site
591946001666	ligand-binding site [chemical binding]; other site
591946001667	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
591946001668	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
591946001669	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
591946001670	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
591946001671	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
591946001672	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
591946001673	acyl-activating enzyme (AAE) consensus motif; other site
591946001674	AMP binding site [chemical binding]; other site
591946001675	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
591946001676	LPS O-antigen length regulator; Provisional; Region: PRK10381
591946001677	Chain length determinant protein; Region: Wzz; pfam02706
591946001678	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
591946001679	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
591946001680	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
591946001681	Walker A/P-loop; other site
591946001682	ATP binding site [chemical binding]; other site
591946001683	Q-loop/lid; other site
591946001684	ABC transporter signature motif; other site
591946001685	Walker B; other site
591946001686	D-loop; other site
591946001687	H-loop/switch region; other site
591946001688	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
591946001689	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591946001690	ABC-ATPase subunit  interface; other site
591946001691	dimer interface [polypeptide binding]; other site
591946001692	putative PBP binding regions; other site
591946001693	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
591946001694	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591946001695	ABC-ATPase subunit  interface; other site
591946001696	dimer interface [polypeptide binding]; other site
591946001697	putative PBP binding regions; other site
591946001698	enterobactin exporter EntS; Provisional; Region: PRK10489
591946001699	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946001700	putative substrate translocation pore; other site
591946001701	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
591946001702	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
591946001703	siderophore binding site; other site
591946001704	isochorismate synthase EntC; Provisional; Region: PRK15016
591946001705	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
591946001706	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
591946001707	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
591946001708	acyl-activating enzyme (AAE) consensus motif; other site
591946001709	active site
591946001710	AMP binding site [chemical binding]; other site
591946001711	substrate binding site [chemical binding]; other site
591946001712	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
591946001713	hydrophobic substrate binding pocket; other site
591946001714	Isochorismatase family; Region: Isochorismatase; pfam00857
591946001715	active site
591946001716	conserved cis-peptide bond; other site
591946001717	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
591946001718	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
591946001719	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
591946001720	putative NAD(P) binding site [chemical binding]; other site
591946001721	active site
591946001722	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
591946001723	CoenzymeA binding site [chemical binding]; other site
591946001724	subunit interaction site [polypeptide binding]; other site
591946001725	PHB binding site; other site
591946001726	carbon starvation protein A; Provisional; Region: PRK15015
591946001727	Carbon starvation protein CstA; Region: CstA; pfam02554
591946001728	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
591946001729	Uncharacterized small protein [Function unknown]; Region: COG2879
591946001730	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
591946001731	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
591946001732	putative active site [active]
591946001733	metal binding site [ion binding]; metal-binding site
591946001734	methionine aminotransferase; Validated; Region: PRK09082
591946001735	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591946001736	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946001737	homodimer interface [polypeptide binding]; other site
591946001738	catalytic residue [active]
591946001739	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
591946001740	ParB-like nuclease domain; Region: ParBc; pfam02195
591946001741	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
591946001742	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
591946001743	Active Sites [active]
591946001744	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
591946001745	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
591946001746	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946001747	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591946001748	dimerization interface [polypeptide binding]; other site
591946001749	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
591946001750	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
591946001751	dimerization domain [polypeptide binding]; other site
591946001752	dimer interface [polypeptide binding]; other site
591946001753	catalytic residues [active]
591946001754	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
591946001755	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
591946001756	dimer interface [polypeptide binding]; other site
591946001757	decamer (pentamer of dimers) interface [polypeptide binding]; other site
591946001758	catalytic triad [active]
591946001759	peroxidatic and resolving cysteines [active]
591946001760	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
591946001761	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
591946001762	catalytic residue [active]
591946001763	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
591946001764	catalytic residues [active]
591946001765	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591946001766	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946001767	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591946001768	Ligand Binding Site [chemical binding]; other site
591946001769	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
591946001770	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
591946001771	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
591946001772	B1 nucleotide binding pocket [chemical binding]; other site
591946001773	B2 nucleotide binding pocket [chemical binding]; other site
591946001774	CAS motifs; other site
591946001775	active site
591946001776	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
591946001777	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
591946001778	transmembrane helices; other site
591946001779	triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096
591946001780	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
591946001781	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
591946001782	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
591946001783	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
591946001784	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
591946001785	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
591946001786	putative active site [active]
591946001787	(T/H)XGH motif; other site
591946001788	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
591946001789	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591946001790	putative active site [active]
591946001791	heme pocket [chemical binding]; other site
591946001792	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946001793	ATP binding site [chemical binding]; other site
591946001794	Mg2+ binding site [ion binding]; other site
591946001795	G-X-G motif; other site
591946001796	two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046
591946001797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946001798	active site
591946001799	phosphorylation site [posttranslational modification]
591946001800	intermolecular recognition site; other site
591946001801	dimerization interface [polypeptide binding]; other site
591946001802	Transcriptional regulator; Region: CitT; pfam12431
591946001803	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
591946001804	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
591946001805	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
591946001806	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591946001807	DNA-binding site [nucleotide binding]; DNA binding site
591946001808	RNA-binding motif; other site
591946001809	chromosome condensation membrane protein; Provisional; Region: PRK14196
591946001810	Predicted amidohydrolase [General function prediction only]; Region: COG0388
591946001811	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
591946001812	putative active site [active]
591946001813	catalytic triad [active]
591946001814	putative dimer interface [polypeptide binding]; other site
591946001815	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
591946001816	lipoyl synthase; Provisional; Region: PRK05481
591946001817	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946001818	FeS/SAM binding site; other site
591946001819	lipoate-protein ligase B; Provisional; Region: PRK14342
591946001820	hypothetical protein; Provisional; Region: PRK04998
591946001821	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
591946001822	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
591946001823	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
591946001824	rare lipoprotein A; Provisional; Region: PRK10672
591946001825	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
591946001826	Sporulation related domain; Region: SPOR; pfam05036
591946001827	cell wall shape-determining protein; Provisional; Region: PRK10794
591946001828	penicillin-binding protein 2; Provisional; Region: PRK10795
591946001829	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
591946001830	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
591946001831	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
591946001832	ribosome-associated protein; Provisional; Region: PRK11538
591946001833	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591946001834	catalytic core [active]
591946001835	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
591946001836	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
591946001837	active site
591946001838	(T/H)XGH motif; other site
591946001839	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
591946001840	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
591946001841	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
591946001842	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
591946001843	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
591946001844	HIGH motif; other site
591946001845	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
591946001846	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
591946001847	active site
591946001848	KMSKS motif; other site
591946001849	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
591946001850	tRNA binding surface [nucleotide binding]; other site
591946001851	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
591946001852	hypothetical protein; Provisional; Region: PRK11032
591946001853	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
591946001854	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
591946001855	active site
591946001856	tetramer interface [polypeptide binding]; other site
591946001857	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
591946001858	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
591946001859	Walker A/P-loop; other site
591946001860	ATP binding site [chemical binding]; other site
591946001861	Q-loop/lid; other site
591946001862	ABC transporter signature motif; other site
591946001863	Walker B; other site
591946001864	D-loop; other site
591946001865	H-loop/switch region; other site
591946001866	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591946001867	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946001868	dimer interface [polypeptide binding]; other site
591946001869	conserved gate region; other site
591946001870	putative PBP binding loops; other site
591946001871	ABC-ATPase subunit interface; other site
591946001872	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591946001873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946001874	dimer interface [polypeptide binding]; other site
591946001875	conserved gate region; other site
591946001876	putative PBP binding loops; other site
591946001877	ABC-ATPase subunit interface; other site
591946001878	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
591946001879	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946001880	substrate binding pocket [chemical binding]; other site
591946001881	membrane-bound complex binding site; other site
591946001882	hinge residues; other site
591946001883	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
591946001884	Uncharacterized conserved protein [Function unknown]; Region: COG3391
591946001885	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
591946001886	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
591946001887	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
591946001888	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
591946001889	putative active site [active]
591946001890	catalytic triad [active]
591946001891	putative dimer interface [polypeptide binding]; other site
591946001892	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
591946001893	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
591946001894	Transporter associated domain; Region: CorC_HlyC; smart01091
591946001895	metal-binding heat shock protein; Provisional; Region: PRK00016
591946001896	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
591946001897	PhoH-like protein; Region: PhoH; pfam02562
591946001898	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
591946001899	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
591946001900	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946001901	FeS/SAM binding site; other site
591946001902	TRAM domain; Region: TRAM; pfam01938
591946001903	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
591946001904	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
591946001905	asparagine synthetase B; Provisional; Region: asnB; PRK09431
591946001906	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
591946001907	active site
591946001908	dimer interface [polypeptide binding]; other site
591946001909	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
591946001910	Ligand Binding Site [chemical binding]; other site
591946001911	Molecular Tunnel; other site
591946001912	UMP phosphatase; Provisional; Region: PRK10444
591946001913	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946001914	active site
591946001915	motif I; other site
591946001916	motif II; other site
591946001917	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946001918	MarR family; Region: MarR; pfam01047
591946001919	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
591946001920	ROK family; Region: ROK; pfam00480
591946001921	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
591946001922	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
591946001923	active site
591946001924	dimer interface [polypeptide binding]; other site
591946001925	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
591946001926	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
591946001927	active site
591946001928	trimer interface [polypeptide binding]; other site
591946001929	allosteric site; other site
591946001930	active site lid [active]
591946001931	hexamer (dimer of trimers) interface [polypeptide binding]; other site
591946001932	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
591946001933	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591946001934	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591946001935	active site turn [active]
591946001936	phosphorylation site [posttranslational modification]
591946001937	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
591946001938	HPr interaction site; other site
591946001939	glycerol kinase (GK) interaction site [polypeptide binding]; other site
591946001940	active site
591946001941	phosphorylation site [posttranslational modification]
591946001942	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
591946001943	transmembrane helices; other site
591946001944	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
591946001945	Domain of unknown function (DUF386); Region: DUF386; cl01047
591946001946	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
591946001947	BNR repeat-like domain; Region: BNR_2; pfam13088
591946001948	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
591946001949	dihydrodipicolinate synthase; Region: dapA; TIGR00674
591946001950	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
591946001951	inhibitor site; inhibition site
591946001952	active site
591946001953	dimer interface [polypeptide binding]; other site
591946001954	catalytic residue [active]
591946001955	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
591946001956	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
591946001957	putative active site [active]
591946001958	metal binding site [ion binding]; metal-binding site
591946001959	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
591946001960	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
591946001961	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
591946001962	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591946001963	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
591946001964	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946001965	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
591946001966	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
591946001967	active site
591946001968	HIGH motif; other site
591946001969	nucleotide binding site [chemical binding]; other site
591946001970	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
591946001971	KMSKS motif; other site
591946001972	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
591946001973	outer membrane porin, OprD family; Region: OprD; pfam03573
591946001974	YbfN-like lipoprotein; Region: YbfN; pfam13982
591946001975	ferric uptake regulator; Provisional; Region: fur; PRK09462
591946001976	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
591946001977	metal binding site 2 [ion binding]; metal-binding site
591946001978	putative DNA binding helix; other site
591946001979	metal binding site 1 [ion binding]; metal-binding site
591946001980	dimer interface [polypeptide binding]; other site
591946001981	structural Zn2+ binding site [ion binding]; other site
591946001982	flavodoxin FldA; Validated; Region: PRK09267
591946001983	LexA regulated protein; Provisional; Region: PRK11675
591946001984	acyl-CoA esterase; Provisional; Region: PRK10673
591946001985	PGAP1-like protein; Region: PGAP1; pfam07819
591946001986	replication initiation regulator SeqA; Provisional; Region: PRK11187
591946001987	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
591946001988	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
591946001989	active site
591946001990	substrate binding site [chemical binding]; other site
591946001991	metal binding site [ion binding]; metal-binding site
591946001992	putrescine transporter; Provisional; Region: potE; PRK10655
591946001993	ornithine decarboxylase; Provisional; Region: PRK13578
591946001994	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
591946001995	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
591946001996	homodimer interface [polypeptide binding]; other site
591946001997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946001998	catalytic residue [active]
591946001999	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
591946002000	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
591946002001	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946002002	active site
591946002003	phosphorylation site [posttranslational modification]
591946002004	intermolecular recognition site; other site
591946002005	dimerization interface [polypeptide binding]; other site
591946002006	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946002007	DNA binding site [nucleotide binding]
591946002008	sensor protein KdpD; Provisional; Region: PRK10490
591946002009	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
591946002010	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
591946002011	Ligand Binding Site [chemical binding]; other site
591946002012	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
591946002013	GAF domain; Region: GAF_3; pfam13492
591946002014	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946002015	dimer interface [polypeptide binding]; other site
591946002016	phosphorylation site [posttranslational modification]
591946002017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946002018	ATP binding site [chemical binding]; other site
591946002019	Mg2+ binding site [ion binding]; other site
591946002020	G-X-G motif; other site
591946002021	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
591946002022	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
591946002023	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591946002024	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
591946002025	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
591946002026	hypothetical protein; Provisional; Region: PRK10167
591946002027	Uncharacterized conserved protein [Function unknown]; Region: COG3272
591946002028	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
591946002029	DNA photolyase; Region: DNA_photolyase; pfam00875
591946002030	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
591946002031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946002032	putative substrate translocation pore; other site
591946002033	POT family; Region: PTR2; pfam00854
591946002034	Uncharacterized conserved protein [Function unknown]; Region: COG0327
591946002035	metal-binding protein; Provisional; Region: PRK10799
591946002036	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
591946002037	sensor histidine kinase inhibitor, KipI family; Region: TIGR00370
591946002038	biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724
591946002039	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
591946002040	putative active site [active]
591946002041	endonuclease VIII; Provisional; Region: PRK10445
591946002042	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
591946002043	DNA binding site [nucleotide binding]
591946002044	catalytic residue [active]
591946002045	putative catalytic residues [active]
591946002046	H2TH interface [polypeptide binding]; other site
591946002047	intercalation triad [nucleotide binding]; other site
591946002048	substrate specificity determining residue; other site
591946002049	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
591946002050	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
591946002051	Putative ammonia monooxygenase; Region: AmoA; pfam05145
591946002052	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
591946002053	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
591946002054	Fimbrial protein; Region: Fimbrial; cl01416
591946002055	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
591946002056	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
591946002057	dimer interface [polypeptide binding]; other site
591946002058	active site
591946002059	citrylCoA binding site [chemical binding]; other site
591946002060	NADH binding [chemical binding]; other site
591946002061	cationic pore residues; other site
591946002062	oxalacetate/citrate binding site [chemical binding]; other site
591946002063	coenzyme A binding site [chemical binding]; other site
591946002064	catalytic triad [active]
591946002065	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
591946002066	Iron-sulfur protein interface; other site
591946002067	proximal quinone binding site [chemical binding]; other site
591946002068	SdhD (CybS) interface [polypeptide binding]; other site
591946002069	proximal heme binding site [chemical binding]; other site
591946002070	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
591946002071	SdhC subunit interface [polypeptide binding]; other site
591946002072	proximal heme binding site [chemical binding]; other site
591946002073	cardiolipin binding site; other site
591946002074	Iron-sulfur protein interface; other site
591946002075	proximal quinone binding site [chemical binding]; other site
591946002076	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
591946002077	L-aspartate oxidase; Provisional; Region: PRK06175
591946002078	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
591946002079	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
591946002080	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
591946002081	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
591946002082	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
591946002083	TPP-binding site [chemical binding]; other site
591946002084	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
591946002085	dimer interface [polypeptide binding]; other site
591946002086	PYR/PP interface [polypeptide binding]; other site
591946002087	TPP binding site [chemical binding]; other site
591946002088	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
591946002089	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
591946002090	E3 interaction surface; other site
591946002091	lipoyl attachment site [posttranslational modification]; other site
591946002092	e3 binding domain; Region: E3_binding; pfam02817
591946002093	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
591946002094	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
591946002095	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
591946002096	CoA-ligase; Region: Ligase_CoA; pfam00549
591946002097	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
591946002098	CoA binding domain; Region: CoA_binding; smart00881
591946002099	CoA-ligase; Region: Ligase_CoA; pfam00549
591946002100	TPR repeat; Region: TPR_11; pfam13414
591946002101	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591946002102	binding surface
591946002103	TPR motif; other site
591946002104	Tetratricopeptide repeat; Region: TPR_12; pfam13424
591946002105	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
591946002106	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
591946002107	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
591946002108	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
591946002109	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
591946002110	hypothetical protein; Provisional; Region: PRK10588
591946002111	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
591946002112	active site
591946002113	colicin uptake protein TolQ; Provisional; Region: PRK10801
591946002114	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
591946002115	colicin uptake protein TolR; Provisional; Region: PRK11024
591946002116	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
591946002117	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
591946002118	TolA C-terminal; Region: TolA; pfam06519
591946002119	translocation protein TolB; Provisional; Region: tolB; PRK03629
591946002120	TolB amino-terminal domain; Region: TolB_N; pfam04052
591946002121	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
591946002122	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
591946002123	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
591946002124	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
591946002125	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
591946002126	ligand binding site [chemical binding]; other site
591946002127	tol-pal system protein YbgF; Provisional; Region: PRK10803
591946002128	Tetratricopeptide repeat; Region: TPR_6; pfam13174
591946002129	Tetratricopeptide repeat; Region: TPR_6; pfam13174
591946002130	quinolinate synthetase; Provisional; Region: PRK09375
591946002131	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
591946002132	zinc transporter ZitB; Provisional; Region: PRK03557
591946002133	YbgS-like protein; Region: YbgS; pfam13985
591946002134	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
591946002135	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
591946002136	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591946002137	catalytic core [active]
591946002138	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591946002139	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
591946002140	active site
591946002141	catalytic residues [active]
591946002142	galactokinase; Provisional; Region: PRK05101
591946002143	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
591946002144	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
591946002145	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
591946002146	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
591946002147	dimer interface [polypeptide binding]; other site
591946002148	active site
591946002149	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
591946002150	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
591946002151	NAD binding site [chemical binding]; other site
591946002152	homodimer interface [polypeptide binding]; other site
591946002153	active site
591946002154	substrate binding site [chemical binding]; other site
591946002155	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
591946002156	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
591946002157	Walker A/P-loop; other site
591946002158	ATP binding site [chemical binding]; other site
591946002159	Q-loop/lid; other site
591946002160	ABC transporter signature motif; other site
591946002161	Walker B; other site
591946002162	D-loop; other site
591946002163	H-loop/switch region; other site
591946002164	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946002165	Walker A/P-loop; other site
591946002166	ATP binding site [chemical binding]; other site
591946002167	Q-loop/lid; other site
591946002168	ABC transporter signature motif; other site
591946002169	Walker B; other site
591946002170	D-loop; other site
591946002171	H-loop/switch region; other site
591946002172	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
591946002173	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
591946002174	molybdenum-pterin binding domain; Region: Mop; TIGR00638
591946002175	TOBE domain; Region: TOBE; pfam03459
591946002176	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
591946002177	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
591946002178	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946002179	substrate binding pocket [chemical binding]; other site
591946002180	membrane-bound complex binding site; other site
591946002181	hinge residues; other site
591946002182	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
591946002183	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946002184	dimer interface [polypeptide binding]; other site
591946002185	conserved gate region; other site
591946002186	putative PBP binding loops; other site
591946002187	ABC-ATPase subunit interface; other site
591946002188	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
591946002189	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946002190	Walker A/P-loop; other site
591946002191	ATP binding site [chemical binding]; other site
591946002192	Q-loop/lid; other site
591946002193	ABC transporter signature motif; other site
591946002194	Walker B; other site
591946002195	D-loop; other site
591946002196	H-loop/switch region; other site
591946002197	molybdenum-pterin binding domain; Region: Mop; TIGR00638
591946002198	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
591946002199	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946002200	motif II; other site
591946002201	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946002202	6-phosphogluconolactonase; Provisional; Region: PRK11028
591946002203	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591946002204	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946002205	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
591946002206	putative dimerization interface [polypeptide binding]; other site
591946002207	PrpF protein; Region: PrpF; pfam04303
591946002208	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
591946002209	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
591946002210	transmembrane helices; other site
591946002211	putative hydratase; Provisional; Region: PRK11413
591946002212	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
591946002213	substrate binding site [chemical binding]; other site
591946002214	ligand binding site [chemical binding]; other site
591946002215	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
591946002216	substrate binding site [chemical binding]; other site
591946002217	acyl-CoA thioesterase; Provisional; Region: PRK10531
591946002218	putative pectinesterase; Region: PLN02432; cl01911
591946002219	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
591946002220	substrate binding site [chemical binding]; other site
591946002221	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
591946002222	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
591946002223	Probable transposase; Region: OrfB_IS605; pfam01385
591946002224	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
591946002225	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
591946002226	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
591946002227	inhibitor-cofactor binding pocket; inhibition site
591946002228	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946002229	catalytic residue [active]
591946002230	biotin synthase; Provisional; Region: PRK15108
591946002231	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946002232	FeS/SAM binding site; other site
591946002233	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
591946002234	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
591946002235	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
591946002236	substrate-cofactor binding pocket; other site
591946002237	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946002238	catalytic residue [active]
591946002239	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
591946002240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946002241	S-adenosylmethionine binding site [chemical binding]; other site
591946002242	AAA domain; Region: AAA_26; pfam13500
591946002243	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
591946002244	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
591946002245	ADP binding site [chemical binding]; other site
591946002246	excinuclease ABC subunit B; Provisional; Region: PRK05298
591946002247	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591946002248	ATP binding site [chemical binding]; other site
591946002249	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591946002250	nucleotide binding region [chemical binding]; other site
591946002251	ATP-binding site [chemical binding]; other site
591946002252	Ultra-violet resistance protein B; Region: UvrB; pfam12344
591946002253	UvrB/uvrC motif; Region: UVR; pfam02151
591946002254	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
591946002255	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
591946002256	putative substrate binding pocket [chemical binding]; other site
591946002257	dimer interface [polypeptide binding]; other site
591946002258	phosphate binding site [ion binding]; other site
591946002259	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
591946002260	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946002261	FeS/SAM binding site; other site
591946002262	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
591946002263	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
591946002264	MPT binding site; other site
591946002265	trimer interface [polypeptide binding]; other site
591946002266	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
591946002267	trimer interface [polypeptide binding]; other site
591946002268	dimer interface [polypeptide binding]; other site
591946002269	putative active site [active]
591946002270	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
591946002271	MoaE interaction surface [polypeptide binding]; other site
591946002272	MoeB interaction surface [polypeptide binding]; other site
591946002273	thiocarboxylated glycine; other site
591946002274	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
591946002275	MoaE homodimer interface [polypeptide binding]; other site
591946002276	MoaD interaction [polypeptide binding]; other site
591946002277	active site residues [active]
591946002278	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
591946002279	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
591946002280	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
591946002281	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
591946002282	Predicted integral membrane protein [Function unknown]; Region: COG0392
591946002283	cardiolipin synthase 2; Provisional; Region: PRK11263
591946002284	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
591946002285	putative active site [active]
591946002286	catalytic site [active]
591946002287	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
591946002288	putative active site [active]
591946002289	catalytic site [active]
591946002290	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
591946002291	putative catalytic site [active]
591946002292	putative metal binding site [ion binding]; other site
591946002293	putative phosphate binding site [ion binding]; other site
591946002294	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
591946002295	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
591946002296	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
591946002297	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
591946002298	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
591946002299	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
591946002300	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591946002301	Walker A/P-loop; other site
591946002302	ATP binding site [chemical binding]; other site
591946002303	Q-loop/lid; other site
591946002304	ABC transporter signature motif; other site
591946002305	Walker B; other site
591946002306	D-loop; other site
591946002307	H-loop/switch region; other site
591946002308	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
591946002309	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591946002310	Walker A/P-loop; other site
591946002311	ATP binding site [chemical binding]; other site
591946002312	Q-loop/lid; other site
591946002313	ABC transporter signature motif; other site
591946002314	Walker B; other site
591946002315	D-loop; other site
591946002316	H-loop/switch region; other site
591946002317	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
591946002318	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946002319	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946002320	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
591946002321	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
591946002322	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
591946002323	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
591946002324	ATP binding site [chemical binding]; other site
591946002325	Mg++ binding site [ion binding]; other site
591946002326	motif III; other site
591946002327	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591946002328	nucleotide binding region [chemical binding]; other site
591946002329	ATP-binding site [chemical binding]; other site
591946002330	536; 55989; APEC_01; ATC8739; CFT073; E24377A; ED1a; HS; IAI1; E2348, S88; SE11; UMN026; UTI89; K12_DH10B; K12_MG1655; K12_W3110
591946002331	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
591946002332	DEAD_2; Region: DEAD_2; pfam06733
591946002333	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
591946002334	glycosyl transferase family protein; Provisional; Region: PRK08136
591946002335	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
591946002336	putative dehydrogenase; Provisional; Region: PRK10098
591946002337	hypothetical protein; Provisional; Region: PRK10259
591946002338	hypothetical protein; Provisional; Region: PRK11019
591946002339	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
591946002340	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
591946002341	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591946002342	N-terminal plug; other site
591946002343	ligand-binding site [chemical binding]; other site
591946002344	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591946002345	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
591946002346	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
591946002347	putative mechanosensitive channel protein; Provisional; Region: PRK11465
591946002348	Mechanosensitive ion channel; Region: MS_channel; pfam00924
591946002349	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
591946002350	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
591946002351	Walker A/P-loop; other site
591946002352	ATP binding site [chemical binding]; other site
591946002353	Q-loop/lid; other site
591946002354	ABC transporter signature motif; other site
591946002355	Walker B; other site
591946002356	D-loop; other site
591946002357	H-loop/switch region; other site
591946002358	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591946002359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946002360	dimer interface [polypeptide binding]; other site
591946002361	conserved gate region; other site
591946002362	putative PBP binding loops; other site
591946002363	ABC-ATPase subunit interface; other site
591946002364	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
591946002365	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946002366	substrate binding pocket [chemical binding]; other site
591946002367	membrane-bound complex binding site; other site
591946002368	hinge residues; other site
591946002369	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
591946002370	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
591946002371	dimerization interface [polypeptide binding]; other site
591946002372	DPS ferroxidase diiron center [ion binding]; other site
591946002373	ion pore; other site
591946002374	threonine and homoserine efflux system; Provisional; Region: PRK10532
591946002375	EamA-like transporter family; Region: EamA; pfam00892
591946002376	outer membrane protein X; Provisional; Region: ompX; PRK09408
591946002377	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
591946002378	Sulfatase; Region: Sulfatase; pfam00884
591946002379	manganese transport regulator MntR; Provisional; Region: PRK11050
591946002380	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
591946002381	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
591946002382	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
591946002383	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
591946002384	transmembrane helices; other site
591946002385	L,D-transpeptidase; Provisional; Region: PRK10260
591946002386	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591946002387	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
591946002388	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946002389	Walker A/P-loop; other site
591946002390	ATP binding site [chemical binding]; other site
591946002391	Q-loop/lid; other site
591946002392	ABC transporter signature motif; other site
591946002393	Walker B; other site
591946002394	D-loop; other site
591946002395	H-loop/switch region; other site
591946002396	ABC transporter; Region: ABC_tran_2; pfam12848
591946002397	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591946002398	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
591946002399	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946002400	active site
591946002401	motif I; other site
591946002402	motif II; other site
591946002403	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946002404	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
591946002405	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
591946002406	dimer interface [polypeptide binding]; other site
591946002407	active site
591946002408	glycine loop; other site
591946002409	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
591946002410	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
591946002411	active site
591946002412	intersubunit interactions; other site
591946002413	catalytic residue [active]
591946002414	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
591946002415	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
591946002416	ATP binding site [chemical binding]; other site
591946002417	substrate interface [chemical binding]; other site
591946002418	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
591946002419	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
591946002420	dimer interface [polypeptide binding]; other site
591946002421	putative functional site; other site
591946002422	putative MPT binding site; other site
591946002423	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
591946002424	catalytic nucleophile [active]
591946002425	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
591946002426	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946002427	Walker A/P-loop; other site
591946002428	ATP binding site [chemical binding]; other site
591946002429	Q-loop/lid; other site
591946002430	ABC transporter signature motif; other site
591946002431	Walker B; other site
591946002432	D-loop; other site
591946002433	H-loop/switch region; other site
591946002434	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
591946002435	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946002436	Walker A/P-loop; other site
591946002437	ATP binding site [chemical binding]; other site
591946002438	Q-loop/lid; other site
591946002439	ABC transporter signature motif; other site
591946002440	Walker B; other site
591946002441	D-loop; other site
591946002442	H-loop/switch region; other site
591946002443	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
591946002444	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
591946002445	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
591946002446	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
591946002447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946002448	dimer interface [polypeptide binding]; other site
591946002449	conserved gate region; other site
591946002450	putative PBP binding loops; other site
591946002451	ABC-ATPase subunit interface; other site
591946002452	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
591946002453	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
591946002454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946002455	dimer interface [polypeptide binding]; other site
591946002456	conserved gate region; other site
591946002457	putative PBP binding loops; other site
591946002458	ABC-ATPase subunit interface; other site
591946002459	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946002460	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591946002461	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946002462	metal binding site [ion binding]; metal-binding site
591946002463	active site
591946002464	I-site; other site
591946002465	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
591946002466	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
591946002467	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946002468	FeS/SAM binding site; other site
591946002469	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
591946002470	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
591946002471	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
591946002472	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
591946002473	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
591946002474	putative C-terminal domain interface [polypeptide binding]; other site
591946002475	putative GSH binding site (G-site) [chemical binding]; other site
591946002476	putative dimer interface [polypeptide binding]; other site
591946002477	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
591946002478	putative N-terminal domain interface [polypeptide binding]; other site
591946002479	putative dimer interface [polypeptide binding]; other site
591946002480	putative substrate binding pocket (H-site) [chemical binding]; other site
591946002481	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
591946002482	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
591946002483	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
591946002484	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
591946002485	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
591946002486	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946002487	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
591946002488	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
591946002489	active site
591946002490	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
591946002491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946002492	putative substrate translocation pore; other site
591946002493	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
591946002494	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946002495	active site
591946002496	motif I; other site
591946002497	motif II; other site
591946002498	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946002499	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
591946002500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946002501	putative substrate translocation pore; other site
591946002502	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591946002503	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
591946002504	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591946002505	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
591946002506	putative transporter; Provisional; Region: PRK04972
591946002507	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
591946002508	TrkA-C domain; Region: TrkA_C; pfam02080
591946002509	TrkA-C domain; Region: TrkA_C; pfam02080
591946002510	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
591946002511	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
591946002512	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
591946002513	GSH binding site [chemical binding]; other site
591946002514	catalytic residues [active]
591946002515	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
591946002516	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
591946002517	dimer interface [polypeptide binding]; other site
591946002518	FMN binding site [chemical binding]; other site
591946002519	NADPH bind site [chemical binding]; other site
591946002520	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
591946002521	RimK-like ATP-grasp domain; Region: RimK; pfam08443
591946002522	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
591946002523	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
591946002524	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
591946002525	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
591946002526	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946002527	Walker A/P-loop; other site
591946002528	ATP binding site [chemical binding]; other site
591946002529	Q-loop/lid; other site
591946002530	ABC transporter signature motif; other site
591946002531	Walker B; other site
591946002532	D-loop; other site
591946002533	H-loop/switch region; other site
591946002534	TOBE domain; Region: TOBE_2; pfam08402
591946002535	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
591946002536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946002537	dimer interface [polypeptide binding]; other site
591946002538	conserved gate region; other site
591946002539	putative PBP binding loops; other site
591946002540	ABC-ATPase subunit interface; other site
591946002541	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
591946002542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946002543	dimer interface [polypeptide binding]; other site
591946002544	conserved gate region; other site
591946002545	putative PBP binding loops; other site
591946002546	ABC-ATPase subunit interface; other site
591946002547	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
591946002548	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
591946002549	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946002550	S-adenosylmethionine binding site [chemical binding]; other site
591946002551	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
591946002552	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946002553	substrate binding pocket [chemical binding]; other site
591946002554	membrane-bound complex binding site; other site
591946002555	hinge residues; other site
591946002556	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946002557	dimer interface [polypeptide binding]; other site
591946002558	conserved gate region; other site
591946002559	putative PBP binding loops; other site
591946002560	ABC-ATPase subunit interface; other site
591946002561	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591946002562	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946002563	dimer interface [polypeptide binding]; other site
591946002564	conserved gate region; other site
591946002565	putative PBP binding loops; other site
591946002566	ABC-ATPase subunit interface; other site
591946002567	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
591946002568	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946002569	substrate binding pocket [chemical binding]; other site
591946002570	membrane-bound complex binding site; other site
591946002571	hinge residues; other site
591946002572	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
591946002573	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946002574	Walker A/P-loop; other site
591946002575	ATP binding site [chemical binding]; other site
591946002576	Q-loop/lid; other site
591946002577	ABC transporter signature motif; other site
591946002578	Walker B; other site
591946002579	D-loop; other site
591946002580	H-loop/switch region; other site
591946002581	putative lipoprotein; Provisional; Region: PRK10533
591946002582	hypothetical protein; Provisional; Region: PRK02877
591946002583	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
591946002584	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
591946002585	amidase catalytic site [active]
591946002586	Zn binding residues [ion binding]; other site
591946002587	substrate binding site [chemical binding]; other site
591946002588	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
591946002589	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591946002590	NAD(P) binding site [chemical binding]; other site
591946002591	active site
591946002592	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
591946002593	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
591946002594	putative NAD(P) binding site [chemical binding]; other site
591946002595	putative active site [active]
591946002596	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
591946002597	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
591946002598	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
591946002599	tetramer interface [polypeptide binding]; other site
591946002600	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946002601	catalytic residue [active]
591946002602	pyruvate dehydrogenase; Provisional; Region: PRK09124
591946002603	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
591946002604	PYR/PP interface [polypeptide binding]; other site
591946002605	dimer interface [polypeptide binding]; other site
591946002606	tetramer interface [polypeptide binding]; other site
591946002607	TPP binding site [chemical binding]; other site
591946002608	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591946002609	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
591946002610	TPP-binding site [chemical binding]; other site
591946002611	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
591946002612	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
591946002613	FAD binding pocket [chemical binding]; other site
591946002614	FAD binding motif [chemical binding]; other site
591946002615	phosphate binding motif [ion binding]; other site
591946002616	beta-alpha-beta structure motif; other site
591946002617	NAD binding pocket [chemical binding]; other site
591946002618	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
591946002619	catalytic loop [active]
591946002620	iron binding site [ion binding]; other site
591946002621	hybrid cluster protein; Provisional; Region: PRK05290
591946002622	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591946002623	ACS interaction site; other site
591946002624	CODH interaction site; other site
591946002625	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
591946002626	hybrid metal cluster; other site
591946002627	Predicted membrane protein [Function unknown]; Region: COG2431
591946002628	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
591946002629	amphipathic channel; other site
591946002630	Asn-Pro-Ala signature motifs; other site
591946002631	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
591946002632	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
591946002633	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
591946002634	putative active site [active]
591946002635	putative metal-binding site [ion binding]; other site
591946002636	Protein of unknown function (DUF535); Region: DUF535; pfam04393
591946002637	macrolide transporter subunit MacA; Provisional; Region: PRK11578
591946002638	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946002639	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946002640	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
591946002641	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591946002642	Walker A/P-loop; other site
591946002643	ATP binding site [chemical binding]; other site
591946002644	Q-loop/lid; other site
591946002645	ABC transporter signature motif; other site
591946002646	Walker B; other site
591946002647	D-loop; other site
591946002648	H-loop/switch region; other site
591946002649	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
591946002650	FtsX-like permease family; Region: FtsX; pfam02687
591946002651	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591946002652	DNA-binding site [nucleotide binding]; DNA binding site
591946002653	RNA-binding motif; other site
591946002654	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
591946002655	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
591946002656	Clp amino terminal domain; Region: Clp_N; pfam02861
591946002657	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946002658	Walker A motif; other site
591946002659	ATP binding site [chemical binding]; other site
591946002660	Walker B motif; other site
591946002661	arginine finger; other site
591946002662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946002663	Walker A motif; other site
591946002664	ATP binding site [chemical binding]; other site
591946002665	Walker B motif; other site
591946002666	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
591946002667	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718
591946002668	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
591946002669	CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562
591946002670	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735
591946002671	CRISPR-associated protein (Cas_Csy2); Region: Cas_Csy2; pfam09614
591946002672	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737
591946002673	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739
591946002674	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
591946002675	rRNA binding site [nucleotide binding]; other site
591946002676	predicted 30S ribosome binding site; other site
591946002677	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
591946002678	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
591946002679	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591946002680	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
591946002681	Walker A/P-loop; other site
591946002682	ATP binding site [chemical binding]; other site
591946002683	Q-loop/lid; other site
591946002684	ABC transporter signature motif; other site
591946002685	Walker B; other site
591946002686	D-loop; other site
591946002687	H-loop/switch region; other site
591946002688	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
591946002689	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591946002690	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946002691	Walker A/P-loop; other site
591946002692	ATP binding site [chemical binding]; other site
591946002693	Q-loop/lid; other site
591946002694	ABC transporter signature motif; other site
591946002695	Walker B; other site
591946002696	D-loop; other site
591946002697	H-loop/switch region; other site
591946002698	thioredoxin reductase; Provisional; Region: PRK10262
591946002699	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591946002700	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946002701	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
591946002702	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591946002703	putative DNA binding site [nucleotide binding]; other site
591946002704	putative Zn2+ binding site [ion binding]; other site
591946002705	AsnC family; Region: AsnC_trans_reg; pfam01037
591946002706	DNA translocase FtsK; Provisional; Region: PRK10263
591946002707	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
591946002708	DNA translocase FtsK; Provisional; Region: PRK10263
591946002709	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
591946002710	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
591946002711	periplasmic chaperone LolA; Region: lolA; TIGR00547
591946002712	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
591946002713	recombination factor protein RarA; Reviewed; Region: PRK13342
591946002714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946002715	Walker A motif; other site
591946002716	ATP binding site [chemical binding]; other site
591946002717	Walker B motif; other site
591946002718	arginine finger; other site
591946002719	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
591946002720	seryl-tRNA synthetase; Provisional; Region: PRK05431
591946002721	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
591946002722	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
591946002723	dimer interface [polypeptide binding]; other site
591946002724	active site
591946002725	motif 1; other site
591946002726	motif 2; other site
591946002727	motif 3; other site
591946002728	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
591946002729	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
591946002730	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
591946002731	putative [Fe4-S4] binding site [ion binding]; other site
591946002732	putative molybdopterin cofactor binding site [chemical binding]; other site
591946002733	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
591946002734	putative molybdopterin cofactor binding site; other site
591946002735	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
591946002736	4Fe-4S binding domain; Region: Fer4; pfam00037
591946002737	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
591946002738	Isochorismatase family; Region: Isochorismatase; pfam00857
591946002739	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
591946002740	catalytic triad [active]
591946002741	dimer interface [polypeptide binding]; other site
591946002742	conserved cis-peptide bond; other site
591946002743	putative MFS family transporter protein; Provisional; Region: PRK03633
591946002744	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946002745	putative substrate translocation pore; other site
591946002746	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
591946002747	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946002748	FeS/SAM binding site; other site
591946002749	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
591946002750	Pyruvate formate lyase 1; Region: PFL1; cd01678
591946002751	coenzyme A binding site [chemical binding]; other site
591946002752	active site
591946002753	catalytic residues [active]
591946002754	glycine loop; other site
591946002755	formate transporter; Provisional; Region: PRK10805
591946002756	uncharacterized domain; Region: TIGR00702
591946002757	YcaO-like family; Region: YcaO; pfam02624
591946002758	Predicted membrane protein [Function unknown]; Region: COG2323
591946002759	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
591946002760	homodimer interface [polypeptide binding]; other site
591946002761	substrate-cofactor binding pocket; other site
591946002762	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946002763	catalytic residue [active]
591946002764	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
591946002765	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
591946002766	hinge; other site
591946002767	active site
591946002768	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
591946002769	cytidylate kinase; Provisional; Region: cmk; PRK00023
591946002770	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
591946002771	CMP-binding site; other site
591946002772	The sites determining sugar specificity; other site
591946002773	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
591946002774	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
591946002775	RNA binding site [nucleotide binding]; other site
591946002776	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
591946002777	RNA binding site [nucleotide binding]; other site
591946002778	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
591946002779	RNA binding site [nucleotide binding]; other site
591946002780	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
591946002781	RNA binding site [nucleotide binding]; other site
591946002782	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
591946002783	RNA binding site [nucleotide binding]; other site
591946002784	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
591946002785	IHF dimer interface [polypeptide binding]; other site
591946002786	IHF - DNA interface [nucleotide binding]; other site
591946002787	ComEC family competence protein; Provisional; Region: PRK11539
591946002788	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
591946002789	ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360
591946002790	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
591946002791	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
591946002792	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591946002793	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
591946002794	Walker A/P-loop; other site
591946002795	ATP binding site [chemical binding]; other site
591946002796	Q-loop/lid; other site
591946002797	ABC transporter signature motif; other site
591946002798	Walker B; other site
591946002799	D-loop; other site
591946002800	H-loop/switch region; other site
591946002801	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
591946002802	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
591946002803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
591946002804	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
591946002805	hypothetical protein; Provisional; Region: PRK11827
591946002806	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
591946002807	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
591946002808	Ligand binding site; other site
591946002809	oligomer interface; other site
591946002810	hypothetical protein; Provisional; Region: PRK10593
591946002811	Uncharacterized conserved protein [Function unknown]; Region: COG1434
591946002812	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
591946002813	putative active site [active]
591946002814	Methyltransferase domain; Region: Methyltransf_31; pfam13847
591946002815	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946002816	S-adenosylmethionine binding site [chemical binding]; other site
591946002817	condesin subunit F; Provisional; Region: PRK05260
591946002818	condesin subunit E; Provisional; Region: PRK05256
591946002819	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
591946002820	MukB N-terminal; Region: MukB; pfam04310
591946002821	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
591946002822	murein L,D-transpeptidase; Provisional; Region: PRK10594
591946002823	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
591946002824	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591946002825	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591946002826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
591946002827	Peptidase M15; Region: Peptidase_M15_3; cl01194
591946002828	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
591946002829	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
591946002830	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591946002831	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946002832	homodimer interface [polypeptide binding]; other site
591946002833	catalytic residue [active]
591946002834	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591946002835	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591946002836	trimer interface [polypeptide binding]; other site
591946002837	eyelet of channel; other site
591946002838	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
591946002839	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
591946002840	putative dimer interface [polypeptide binding]; other site
591946002841	putative anticodon binding site; other site
591946002842	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
591946002843	homodimer interface [polypeptide binding]; other site
591946002844	motif 1; other site
591946002845	motif 2; other site
591946002846	active site
591946002847	motif 3; other site
591946002848	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
591946002849	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
591946002850	active site
591946002851	aminopeptidase N; Provisional; Region: pepN; PRK14015
591946002852	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
591946002853	active site
591946002854	Zn binding site [ion binding]; other site
591946002855	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
591946002856	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
591946002857	Walker A/P-loop; other site
591946002858	ATP binding site [chemical binding]; other site
591946002859	Q-loop/lid; other site
591946002860	ABC transporter signature motif; other site
591946002861	Walker B; other site
591946002862	D-loop; other site
591946002863	H-loop/switch region; other site
591946002864	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
591946002865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946002866	dimer interface [polypeptide binding]; other site
591946002867	conserved gate region; other site
591946002868	putative PBP binding loops; other site
591946002869	ABC-ATPase subunit interface; other site
591946002870	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
591946002871	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
591946002872	active site
591946002873	dimer interface [polypeptide binding]; other site
591946002874	non-prolyl cis peptide bond; other site
591946002875	insertion regions; other site
591946002876	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946002877	substrate binding pocket [chemical binding]; other site
591946002878	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
591946002879	membrane-bound complex binding site; other site
591946002880	hinge residues; other site
591946002881	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
591946002882	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
591946002883	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
591946002884	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
591946002885	quinone interaction residues [chemical binding]; other site
591946002886	active site
591946002887	catalytic residues [active]
591946002888	FMN binding site [chemical binding]; other site
591946002889	substrate binding site [chemical binding]; other site
591946002890	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
591946002891	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
591946002892	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
591946002893	MOSC domain; Region: MOSC; pfam03473
591946002894	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
591946002895	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
591946002896	catalytic loop [active]
591946002897	iron binding site [ion binding]; other site
591946002898	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
591946002899	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
591946002900	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
591946002901	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946002902	S-adenosylmethionine binding site [chemical binding]; other site
591946002903	ABC transporter ATPase component; Reviewed; Region: PRK11147
591946002904	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946002905	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946002906	Walker A/P-loop; other site
591946002907	Walker A/P-loop; other site
591946002908	ATP binding site [chemical binding]; other site
591946002909	ATP binding site [chemical binding]; other site
591946002910	Q-loop/lid; other site
591946002911	Q-loop/lid; other site
591946002912	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591946002913	ABC transporter signature motif; other site
591946002914	Walker B; other site
591946002915	D-loop; other site
591946002916	ABC transporter; Region: ABC_tran_2; pfam12848
591946002917	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591946002918	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
591946002919	Paraquat-inducible protein A; Region: PqiA; pfam04403
591946002920	Paraquat-inducible protein A; Region: PqiA; pfam04403
591946002921	paraquat-inducible protein B; Provisional; Region: PRK10807
591946002922	mce related protein; Region: MCE; pfam02470
591946002923	mce related protein; Region: MCE; pfam02470
591946002924	mce related protein; Region: MCE; pfam02470
591946002925	DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651
591946002926	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
591946002927	Protein of unknown function (DUF330); Region: DUF330; pfam03886
591946002928	ribosome modulation factor; Provisional; Region: PRK14563
591946002929	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
591946002930	active site 1 [active]
591946002931	dimer interface [polypeptide binding]; other site
591946002932	active site 2 [active]
591946002933	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
591946002934	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
591946002935	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
591946002936	outer membrane protein A; Reviewed; Region: PRK10808
591946002937	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
591946002938	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
591946002939	ligand binding site [chemical binding]; other site
591946002940	cell division inhibitor SulA; Region: sula; TIGR00623
591946002941	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
591946002942	TfoX C-terminal domain; Region: TfoX_C; pfam04994
591946002943	TIGR01666 family membrane protein; Region: YCCS
591946002944	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
591946002945	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
591946002946	Predicted membrane protein [Function unknown]; Region: COG3304
591946002947	Domain of unknown function (DUF307); Region: DUF307; pfam03733
591946002948	Domain of unknown function (DUF307); Region: DUF307; pfam03733
591946002949	DNA helicase IV; Provisional; Region: helD; PRK11054
591946002950	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
591946002951	Part of AAA domain; Region: AAA_19; pfam13245
591946002952	Family description; Region: UvrD_C_2; pfam13538
591946002953	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
591946002954	active site
591946002955	dimer interfaces [polypeptide binding]; other site
591946002956	catalytic residues [active]
591946002957	hypothetical protein; Provisional; Region: PRK03641
591946002958	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110
591946002959	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
591946002960	heat shock protein HspQ; Provisional; Region: PRK14129
591946002961	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
591946002962	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
591946002963	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
591946002964	putative RNA binding site [nucleotide binding]; other site
591946002965	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946002966	S-adenosylmethionine binding site [chemical binding]; other site
591946002967	Acylphosphatase; Region: Acylphosphatase; cl00551
591946002968	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
591946002969	sulfur transfer protein TusE; Provisional; Region: PRK11508
591946002970	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
591946002971	YccA-like proteins; Region: YccA_like; cd10433
591946002972	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
591946002973	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
591946002974	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
591946002975	hydrogenase 1 large subunit; Provisional; Region: PRK10170
591946002976	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
591946002977	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
591946002978	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
591946002979	putative substrate-binding site; other site
591946002980	nickel binding site [ion binding]; other site
591946002981	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
591946002982	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
591946002983	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
591946002984	cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035
591946002985	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
591946002986	cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028
591946002987	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
591946002988	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
591946002989	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
591946002990	catalytic core [active]
591946002991	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
591946002992	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591946002993	DNA-binding site [nucleotide binding]; DNA binding site
591946002994	RNA-binding motif; other site
591946002995	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591946002996	DNA-binding site [nucleotide binding]; DNA binding site
591946002997	RNA-binding motif; other site
591946002998	cold shock gene; Provisional; Region: PRK09891
591946002999	GnsA/GnsB family; Region: GnsAB; pfam08178
591946003000	4Fe-4S binding domain; Region: Fer4_5; pfam12801
591946003001	4Fe-4S binding domain; Region: Fer4_5; pfam12801
591946003002	Ferredoxin [Energy production and conversion]; Region: NapF; COG1145
591946003003	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591946003004	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
591946003005	hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466
591946003006	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
591946003007	dimerization interface [polypeptide binding]; other site
591946003008	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946003009	dimer interface [polypeptide binding]; other site
591946003010	phosphorylation site [posttranslational modification]
591946003011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946003012	ATP binding site [chemical binding]; other site
591946003013	Mg2+ binding site [ion binding]; other site
591946003014	G-X-G motif; other site
591946003015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946003016	active site
591946003017	phosphorylation site [posttranslational modification]
591946003018	intermolecular recognition site; other site
591946003019	dimerization interface [polypeptide binding]; other site
591946003020	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
591946003021	putative binding surface; other site
591946003022	active site
591946003023	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
591946003024	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
591946003025	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
591946003026	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
591946003027	dimer interface [polypeptide binding]; other site
591946003028	active site
591946003029	Int/Topo IB signature motif; other site
591946003030	Excisionase-like protein; Region: Exc; pfam07825
591946003031	Protein of unknown function (DUF551); Region: DUF551; pfam04448
591946003032	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
591946003033	urea carboxylase; Region: urea_carbox; TIGR02712
591946003034	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
591946003035	RecT family; Region: RecT; pfam03837
591946003036	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946003037	non-specific DNA binding site [nucleotide binding]; other site
591946003038	salt bridge; other site
591946003039	sequence-specific DNA binding site [nucleotide binding]; other site
591946003040	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
591946003041	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
591946003042	Catalytic site [active]
591946003043	DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744
591946003044	Bacteriophage CII protein; Region: Phage_CII; pfam05269
591946003045	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
591946003046	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
591946003047	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
591946003048	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
591946003049	Walker A motif; other site
591946003050	ATP binding site [chemical binding]; other site
591946003051	Walker B motif; other site
591946003052	DNA binding loops [nucleotide binding]
591946003053	NinB protein; Region: NinB; pfam05772
591946003054	NINE Protein; Region: NinE; pfam05322
591946003055	NinF protein; Region: NinF; pfam05810
591946003056	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
591946003057	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645
591946003058	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
591946003059	Endodeoxyribonuclease RusA; Region: RusA; cl01885
591946003060	Phage NinH protein; Region: Phage_NinH; pfam06322
591946003061	Antitermination protein; Region: Antiterm; pfam03589
591946003062	Antitermination protein; Region: Antiterm; pfam03589
591946003063	phage holin, lambda family; Region: holin_lambda; TIGR01594
591946003064	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
591946003065	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591946003066	catalytic residue [active]
591946003067	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
591946003068	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
591946003069	ORF11CD3 domain; Region: ORF11CD3; pfam10549
591946003070	Protein of unknown function (DUF2560); Region: DUF2560; pfam10834
591946003071	hypothetical protein; Region: PHA00781
591946003072	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
591946003073	Phage terminase large subunit; Region: Terminase_3; pfam04466
591946003074	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
591946003075	P22 tail accessory factor; Region: P22_Tail-4; pfam11650
591946003076	Phage stabilisation protein; Region: Phage_stabilise; pfam11134
591946003077	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
591946003078	Protein of unknown function (DUF2824); Region: DUF2824; pfam11039
591946003079	PEGA domain; Region: PEGA; pfam08308
591946003080	Mnt; Region: mnt; PHA01513
591946003081	Arc-like DNA binding domain; Region: Arc; pfam03869
591946003082	Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423
591946003083	Head binding; Region: Head_binding; pfam09008
591946003084	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
591946003085	TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306
591946003086	putative ligand binding site [chemical binding]; other site
591946003087	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
591946003088	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946003089	active site
591946003090	phosphorylation site [posttranslational modification]
591946003091	intermolecular recognition site; other site
591946003092	dimerization interface [polypeptide binding]; other site
591946003093	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946003094	DNA binding site [nucleotide binding]
591946003095	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
591946003096	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
591946003097	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
591946003098	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
591946003099	molybdopterin cofactor binding site [chemical binding]; other site
591946003100	substrate binding site [chemical binding]; other site
591946003101	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
591946003102	molybdopterin cofactor binding site; other site
591946003103	chaperone protein TorD; Validated; Region: torD; PRK04976
591946003104	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
591946003105	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
591946003106	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
591946003107	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
591946003108	HSP70 interaction site [polypeptide binding]; other site
591946003109	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
591946003110	substrate binding site [polypeptide binding]; other site
591946003111	dimer interface [polypeptide binding]; other site
591946003112	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
591946003113	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
591946003114	catalytic core [active]
591946003115	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
591946003116	hypothetical protein; Provisional; Region: PRK10174
591946003117	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
591946003118	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
591946003119	General stress protein [General function prediction only]; Region: GsiB; COG3729
591946003120	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
591946003121	pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615
591946003122	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
591946003123	putative FMN binding site [chemical binding]; other site
591946003124	pyrimidine utilization protein D; Region: RutD; TIGR03611
591946003125	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
591946003126	homotrimer interaction site [polypeptide binding]; other site
591946003127	putative active site [active]
591946003128	Isochorismatase family; Region: Isochorismatase; pfam00857
591946003129	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
591946003130	catalytic triad [active]
591946003131	conserved cis-peptide bond; other site
591946003132	pyrimidine utilization protein A; Region: RutA; TIGR03612
591946003133	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
591946003134	active site
591946003135	dimer interface [polypeptide binding]; other site
591946003136	non-prolyl cis peptide bond; other site
591946003137	insertion regions; other site
591946003138	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
591946003139	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591946003140	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
591946003141	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
591946003142	Predicted transcriptional regulator [Transcription]; Region: COG3905
591946003143	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
591946003144	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
591946003145	Glutamate binding site [chemical binding]; other site
591946003146	NAD binding site [chemical binding]; other site
591946003147	catalytic residues [active]
591946003148	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
591946003149	Na binding site [ion binding]; other site
591946003150	FTR1 family protein; Region: TIGR00145
591946003151	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
591946003152	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
591946003153	Imelysin; Region: Peptidase_M75; pfam09375
591946003154	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
591946003155	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
591946003156	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
591946003157	hypothetical protein; Provisional; Region: PRK10536
591946003158	putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585
591946003159	N-glycosyltransferase; Provisional; Region: PRK11204
591946003160	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
591946003161	DXD motif; other site
591946003162	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
591946003163	outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582
591946003164	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
591946003165	putative active site [active]
591946003166	putative metal binding site [ion binding]; other site
591946003167	outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049
591946003168	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591946003169	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946003170	metal binding site [ion binding]; metal-binding site
591946003171	active site
591946003172	I-site; other site
591946003173	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
591946003174	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
591946003175	putative ligand binding site [chemical binding]; other site
591946003176	NAD binding site [chemical binding]; other site
591946003177	dimerization interface [polypeptide binding]; other site
591946003178	catalytic site [active]
591946003179	putative hydrolase; Validated; Region: PRK09248
591946003180	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
591946003181	active site
591946003182	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
591946003183	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
591946003184	curli production assembly/transport protein CsgG; Provisional; Region: PRK15184
591946003185	curli assembly protein CsgF; Provisional; Region: PRK10050
591946003186	curli assembly protein CsgE; Provisional; Region: PRK10386
591946003187	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
591946003188	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946003189	DNA binding residues [nucleotide binding]
591946003190	dimerization interface [polypeptide binding]; other site
591946003191	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
591946003192	Curlin associated repeat; Region: Curlin_rpt; pfam07012
591946003193	Curlin associated repeat; Region: Curlin_rpt; pfam07012
591946003194	major curlin subunit; Provisional; Region: csgA; PRK10051
591946003195	Curlin associated repeat; Region: Curlin_rpt; pfam07012
591946003196	Curlin associated repeat; Region: Curlin_rpt; pfam07012
591946003197	curli assembly protein CsgC; Provisional; Region: csgC; PRK10102
591946003198	Fimbrial protein; Region: Fimbrial; cl01416
591946003199	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
591946003200	putative ADP-ribose binding site [chemical binding]; other site
591946003201	putative active site [active]
591946003202	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
591946003203	PLD-like domain; Region: PLDc_2; pfam13091
591946003204	putative active site [active]
591946003205	catalytic site [active]
591946003206	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
591946003207	PLD-like domain; Region: PLDc_2; pfam13091
591946003208	putative active site [active]
591946003209	catalytic site [active]
591946003210	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
591946003211	Acyltransferase family; Region: Acyl_transf_3; pfam01757
591946003212	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
591946003213	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349
591946003214	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
591946003215	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
591946003216	Ligand binding site; other site
591946003217	DXD motif; other site
591946003218	lipoprotein; Provisional; Region: PRK10175
591946003219	secY/secA suppressor protein; Provisional; Region: PRK11467
591946003220	drug efflux system protein MdtG; Provisional; Region: PRK09874
591946003221	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946003222	putative substrate translocation pore; other site
591946003223	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
591946003224	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
591946003225	putative acyl-acceptor binding pocket; other site
591946003226	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
591946003227	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
591946003228	active site residue [active]
591946003229	hypothetical protein; Provisional; Region: PRK03757
591946003230	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
591946003231	Protein of unknown function (DUF2770); Region: DUF2770; pfam10968
591946003232	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
591946003233	hydroxyglutarate oxidase; Provisional; Region: PRK11728
591946003234	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
591946003235	DNA damage-inducible protein I; Provisional; Region: PRK10597
591946003236	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
591946003237	active site
591946003238	substrate binding pocket [chemical binding]; other site
591946003239	dimer interface [polypeptide binding]; other site
591946003240	lipoprotein; Provisional; Region: PRK10598
591946003241	glutaredoxin 2; Provisional; Region: PRK10387
591946003242	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
591946003243	C-terminal domain interface [polypeptide binding]; other site
591946003244	GSH binding site (G-site) [chemical binding]; other site
591946003245	catalytic residues [active]
591946003246	putative dimer interface [polypeptide binding]; other site
591946003247	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
591946003248	N-terminal domain interface [polypeptide binding]; other site
591946003249	multidrug resistance protein MdtH; Provisional; Region: PRK11646
591946003250	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946003251	putative substrate translocation pore; other site
591946003252	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
591946003253	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
591946003254	hypothetical protein; Provisional; Region: PRK11239
591946003255	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
591946003256	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
591946003257	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
591946003258	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
591946003259	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
591946003260	MviN-like protein; Region: MVIN; pfam03023
591946003261	FlgN protein; Region: FlgN; cl09176
591946003262	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
591946003263	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
591946003264	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
591946003265	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
591946003266	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
591946003267	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
591946003268	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
591946003269	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
591946003270	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
591946003271	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
591946003272	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
591946003273	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
591946003274	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
591946003275	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
591946003276	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
591946003277	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
591946003278	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
591946003279	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
591946003280	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
591946003281	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
591946003282	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
591946003283	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
591946003284	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
591946003285	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
591946003286	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
591946003287	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
591946003288	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
591946003289	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
591946003290	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
591946003291	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
591946003292	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
591946003293	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
591946003294	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
591946003295	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
591946003296	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
591946003297	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
591946003298	homodimer interface [polypeptide binding]; other site
591946003299	oligonucleotide binding site [chemical binding]; other site
591946003300	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
591946003301	Protein of unknown function (DUF2655); Region: DUF2655; pfam10848
591946003302	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
591946003303	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591946003304	RNA binding surface [nucleotide binding]; other site
591946003305	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
591946003306	active site
591946003307	Maf-like protein; Region: Maf; pfam02545
591946003308	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
591946003309	active site
591946003310	dimer interface [polypeptide binding]; other site
591946003311	hypothetical protein; Provisional; Region: PRK11193
591946003312	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
591946003313	putative phosphate acyltransferase; Provisional; Region: PRK05331
591946003314	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
591946003315	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
591946003316	dimer interface [polypeptide binding]; other site
591946003317	active site
591946003318	CoA binding pocket [chemical binding]; other site
591946003319	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
591946003320	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
591946003321	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
591946003322	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
591946003323	NAD(P) binding site [chemical binding]; other site
591946003324	homotetramer interface [polypeptide binding]; other site
591946003325	homodimer interface [polypeptide binding]; other site
591946003326	active site
591946003327	acyl carrier protein; Provisional; Region: acpP; PRK00982
591946003328	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
591946003329	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
591946003330	dimer interface [polypeptide binding]; other site
591946003331	active site
591946003332	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
591946003333	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
591946003334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946003335	catalytic residue [active]
591946003336	conserved hypothetical protein, YceG family; Region: TIGR00247
591946003337	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
591946003338	dimerization interface [polypeptide binding]; other site
591946003339	thymidylate kinase; Validated; Region: tmk; PRK00698
591946003340	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
591946003341	TMP-binding site; other site
591946003342	ATP-binding site [chemical binding]; other site
591946003343	DNA polymerase III subunit delta'; Validated; Region: PRK07993
591946003344	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
591946003345	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
591946003346	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
591946003347	active site
591946003348	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
591946003349	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591946003350	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591946003351	active site turn [active]
591946003352	phosphorylation site [posttranslational modification]
591946003353	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
591946003354	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591946003355	N-terminal plug; other site
591946003356	ligand-binding site [chemical binding]; other site
591946003357	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
591946003358	nucleotide binding site/active site [active]
591946003359	HIT family signature motif; other site
591946003360	catalytic residue [active]
591946003361	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
591946003362	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
591946003363	putative dimer interface [polypeptide binding]; other site
591946003364	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
591946003365	thiamine kinase; Region: ycfN_thiK; TIGR02721
591946003366	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
591946003367	active site
591946003368	substrate binding site [chemical binding]; other site
591946003369	ATP binding site [chemical binding]; other site
591946003370	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
591946003371	beta-hexosaminidase; Provisional; Region: PRK05337
591946003372	hypothetical protein; Provisional; Region: PRK04940
591946003373	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
591946003374	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946003375	hypothetical protein; Provisional; Region: PRK11280
591946003376	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591946003377	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591946003378	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591946003379	L,D-transpeptidase; Provisional; Region: PRK10260
591946003380	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591946003381	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591946003382	transcription-repair coupling factor; Provisional; Region: PRK10689
591946003383	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
591946003384	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591946003385	ATP binding site [chemical binding]; other site
591946003386	putative Mg++ binding site [ion binding]; other site
591946003387	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591946003388	nucleotide binding region [chemical binding]; other site
591946003389	ATP-binding site [chemical binding]; other site
591946003390	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
591946003391	Predicted membrane protein [Function unknown]; Region: COG4763
591946003392	Acyltransferase family; Region: Acyl_transf_3; pfam01757
591946003393	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
591946003394	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
591946003395	FtsX-like permease family; Region: FtsX; pfam02687
591946003396	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
591946003397	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591946003398	Walker A/P-loop; other site
591946003399	ATP binding site [chemical binding]; other site
591946003400	Q-loop/lid; other site
591946003401	ABC transporter signature motif; other site
591946003402	Walker B; other site
591946003403	D-loop; other site
591946003404	H-loop/switch region; other site
591946003405	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
591946003406	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
591946003407	FtsX-like permease family; Region: FtsX; pfam02687
591946003408	fructokinase; Reviewed; Region: PRK09557
591946003409	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591946003410	nucleotide binding site [chemical binding]; other site
591946003411	Nad-dependent deacetylase
591946003412	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
591946003413	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
591946003414	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
591946003415	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
591946003416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946003417	dimer interface [polypeptide binding]; other site
591946003418	conserved gate region; other site
591946003419	putative PBP binding loops; other site
591946003420	ABC-ATPase subunit interface; other site
591946003421	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
591946003422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946003423	dimer interface [polypeptide binding]; other site
591946003424	conserved gate region; other site
591946003425	putative PBP binding loops; other site
591946003426	ABC-ATPase subunit interface; other site
591946003427	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
591946003428	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946003429	Walker A/P-loop; other site
591946003430	ATP binding site [chemical binding]; other site
591946003431	Q-loop/lid; other site
591946003432	ABC transporter signature motif; other site
591946003433	Walker B; other site
591946003434	D-loop; other site
591946003435	H-loop/switch region; other site
591946003436	TOBE domain; Region: TOBE_2; pfam08402
591946003437	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
591946003438	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
591946003439	metal binding site [ion binding]; metal-binding site
591946003440	dimer interface [polypeptide binding]; other site
591946003441	Uncharacterized conserved protein [Function unknown]; Region: COG2850
591946003442	Cupin-like domain; Region: Cupin_8; pfam13621
591946003443	sensor protein PhoQ; Provisional; Region: PRK10815
591946003444	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
591946003445	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
591946003446	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
591946003447	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946003448	ATP binding site [chemical binding]; other site
591946003449	Mg2+ binding site [ion binding]; other site
591946003450	G-X-G motif; other site
591946003451	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
591946003452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946003453	active site
591946003454	phosphorylation site [posttranslational modification]
591946003455	intermolecular recognition site; other site
591946003456	dimerization interface [polypeptide binding]; other site
591946003457	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946003458	DNA binding site [nucleotide binding]
591946003459	adenylosuccinate lyase; Provisional; Region: PRK09285
591946003460	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
591946003461	tetramer interface [polypeptide binding]; other site
591946003462	active site
591946003463	putative lysogenization regulator; Reviewed; Region: PRK00218
591946003464	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
591946003465	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
591946003466	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
591946003467	nudix motif; other site
591946003468	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
591946003469	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
591946003470	probable active site [active]
591946003471	isocitrate dehydrogenase; Validated; Region: PRK07362
591946003472	isocitrate dehydrogenase; Reviewed; Region: PRK07006
591946003473	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
591946003474	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
591946003475	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
591946003476	dimer interface [polypeptide binding]; other site
591946003477	active site
591946003478	Int/Topo IB signature motif; other site
591946003479	Domain of unknown function (DUF4222); Region: DUF4222; pfam13973
591946003480	DksA-like zinc finger domain containing protein; Region: PHA00080
591946003481	Protein of unknown function (DUF1382); Region: DUF1382; pfam07131
591946003482	Protein of unknown function (DUF1317); Region: DUF1317; pfam07026
591946003483	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
591946003484	phage recombination protein Bet; Region: bet_lambda; TIGR01913
591946003485	Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064
591946003486	FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354
591946003487	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946003488	non-specific DNA binding site [nucleotide binding]; other site
591946003489	Predicted transcriptional regulator [Transcription]; Region: COG2932
591946003490	salt bridge; other site
591946003491	sequence-specific DNA binding site [nucleotide binding]; other site
591946003492	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
591946003493	Catalytic site [active]
591946003494	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
591946003495	Protein of unknown function (DUF1019); Region: DUF1019; pfam06254
591946003496	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
591946003497	Replication protein P; Region: Phage_lambda_P; pfam06992
591946003498	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
591946003499	putative Zn2+ binding site [ion binding]; other site
591946003500	putative DNA binding site [nucleotide binding]; other site
591946003501	multidrug efflux protein; Reviewed; Region: emrE; PRK09541
591946003502	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
591946003503	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
591946003504	catalytic residues [active]
591946003505	catalytic nucleophile [active]
591946003506	Recombinase; Region: Recombinase; pfam07508
591946003507	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
591946003508	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
591946003509	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
591946003510	hypothetical protein; Provisional; Region: PRK09741
591946003511	prophage protein NinE; Provisional; Region: PRK09689
591946003512	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
591946003513	endodeoxyribonuclease RUS; Reviewed; Region: PRK09786
591946003514	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
591946003515	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591946003516	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591946003517	trimer interface [polypeptide binding]; other site
591946003518	eyelet of channel; other site
591946003519	Lysis protein S; Region: Lysis_S; pfam04971
591946003520	Protein of unknown function (DUF1327); Region: DUF1327; pfam07041
591946003521	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
591946003522	catalytic residues [active]
591946003523	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
591946003524	Bor protein; Region: Lambda_Bor; pfam06291
591946003525	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
591946003526	Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471
591946003527	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
591946003528	gpW; Region: gpW; pfam02831
591946003529	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
591946003530	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
591946003531	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
591946003532	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
591946003533	tandem repeat interface [polypeptide binding]; other site
591946003534	oligomer interface [polypeptide binding]; other site
591946003535	active site residues [active]
591946003536	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
591946003537	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
591946003538	DNA packaging protein FI; Region: Packaging_FI; pfam14000
591946003539	Phage Head-Tail Attachment; Region: Phage_attach; pfam05354
591946003540	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
591946003541	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
591946003542	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
591946003543	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
591946003544	phage minor tail protein G; Region: phage_lambda_G; TIGR01674
591946003545	Minor tail protein T; Region: Phage_tail_T; pfam06223
591946003546	Phage-related minor tail protein [Function unknown]; Region: COG5281
591946003547	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
591946003548	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
591946003549	Phage-related protein [Function unknown]; Region: COG4718
591946003550	Phage-related protein [Function unknown]; Region: gp18; COG4672
591946003551	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
591946003552	MPN+ (JAMM) motif; other site
591946003553	Zinc-binding site [ion binding]; other site
591946003554	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
591946003555	NlpC/P60 family; Region: NLPC_P60; cl17555
591946003556	Phage-related protein, tail component [Function unknown]; Region: COG4723
591946003557	Phage-related protein, tail component [Function unknown]; Region: COG4733
591946003558	Putative phage tail protein; Region: Phage-tail_3; pfam13550
591946003559	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
591946003560	Interdomain contacts; other site
591946003561	Cytokine receptor motif; other site
591946003562	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
591946003563	Fibronectin type III protein; Region: DUF3672; pfam12421
591946003564	Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316
591946003565	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
591946003566	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
591946003567	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
591946003568	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591946003569	ABC-ATPase subunit  interface; other site
591946003570	dimer interface [polypeptide binding]; other site
591946003571	putative PBP binding regions; other site
591946003572	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
591946003573	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591946003574	ABC-ATPase subunit  interface; other site
591946003575	dimer interface [polypeptide binding]; other site
591946003576	putative PBP binding regions; other site
591946003577	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
591946003578	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
591946003579	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
591946003580	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
591946003581	metal binding site [ion binding]; metal-binding site
591946003582	Protein of unknown function (DUF1398); Region: DUF1398; pfam07166
591946003583	transcriptional regulator MirA; Provisional; Region: PRK15043
591946003584	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
591946003585	DNA binding residues [nucleotide binding]
591946003586	Sensors of blue-light using FAD; Region: BLUF; smart01034
591946003587	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946003588	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
591946003589	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
591946003590	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946003591	Autotransporter beta-domain; Region: Autotransporter; cl17461
591946003592	Autotransporter beta-domain; Region: Autotransporter; smart00869
591946003593	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
591946003594	cell division inhibitor MinD; Provisional; Region: PRK10818
591946003595	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
591946003596	Switch I; other site
591946003597	Switch II; other site
591946003598	septum formation inhibitor; Reviewed; Region: minC; PRK03511
591946003599	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
591946003600	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
591946003601	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
591946003602	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
591946003603	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
591946003604	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
591946003605	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
591946003606	hypothetical protein; Provisional; Region: PRK10691
591946003607	hypothetical protein; Provisional; Region: PRK05170
591946003608	Haemolysin E (HlyE); Region: HlyE; cl11627
591946003609	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
591946003610	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
591946003611	Catalytic site [active]
591946003612	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
591946003613	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
591946003614	active site
591946003615	DNA binding site [nucleotide binding]
591946003616	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
591946003617	disulfide bond formation protein B; Provisional; Region: PRK01749
591946003618	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
591946003619	transmembrane helices; other site
591946003620	fatty acid metabolism regulator; Provisional; Region: PRK04984
591946003621	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946003622	DNA-binding site [nucleotide binding]; DNA binding site
591946003623	FadR C-terminal domain; Region: FadR_C; pfam07840
591946003624	SpoVR family protein; Provisional; Region: PRK11767
591946003625	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
591946003626	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
591946003627	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946003628	alanine racemase; Reviewed; Region: dadX; PRK03646
591946003629	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
591946003630	active site
591946003631	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591946003632	substrate binding site [chemical binding]; other site
591946003633	catalytic residues [active]
591946003634	dimer interface [polypeptide binding]; other site
591946003635	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
591946003636	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
591946003637	TrkA-C domain; Region: TrkA_C; pfam02080
591946003638	Transporter associated domain; Region: CorC_HlyC; smart01091
591946003639	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
591946003640	dimer interface [polypeptide binding]; other site
591946003641	catalytic triad [active]
591946003642	lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470
591946003643	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591946003644	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591946003645	catalytic residue [active]
591946003646	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
591946003647	Flagellar regulator YcgR; Region: YcgR; pfam07317
591946003648	PilZ domain; Region: PilZ; pfam07238
591946003649	hypothetical protein; Provisional; Region: PRK10457
591946003650	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591946003651	N-terminal plug; other site
591946003652	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
591946003653	ligand-binding site [chemical binding]; other site
591946003654	molybdenum transport protein ModD; Provisional; Region: PRK06096
591946003655	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
591946003656	dimerization interface [polypeptide binding]; other site
591946003657	active site
591946003658	Methyltransferase domain; Region: Methyltransf_31; pfam13847
591946003659	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946003660	S-adenosylmethionine binding site [chemical binding]; other site
591946003661	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
591946003662	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
591946003663	Walker A/P-loop; other site
591946003664	ATP binding site [chemical binding]; other site
591946003665	Q-loop/lid; other site
591946003666	ABC transporter signature motif; other site
591946003667	Walker B; other site
591946003668	D-loop; other site
591946003669	H-loop/switch region; other site
591946003670	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
591946003671	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591946003672	ABC-ATPase subunit  interface; other site
591946003673	dimer interface [polypeptide binding]; other site
591946003674	putative PBP binding regions; other site
591946003675	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
591946003676	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
591946003677	putative metal binding site [ion binding]; other site
591946003678	trehalase; Provisional; Region: treA; PRK13271
591946003679	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
591946003680	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
591946003681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412
591946003682	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
591946003683	dimerization domain swap beta strand [polypeptide binding]; other site
591946003684	regulatory protein interface [polypeptide binding]; other site
591946003685	active site
591946003686	regulatory phosphorylation site [posttranslational modification]; other site
591946003687	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
591946003688	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591946003689	dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005
591946003690	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468
591946003691	Dak1 domain; Region: Dak1; pfam02733
591946003692	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
591946003693	PAS domain; Region: PAS; smart00091
591946003694	putative active site [active]
591946003695	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946003696	Walker A motif; other site
591946003697	ATP binding site [chemical binding]; other site
591946003698	Walker B motif; other site
591946003699	arginine finger; other site
591946003700	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
591946003701	GTP-binding protein YchF; Reviewed; Region: PRK09601
591946003702	YchF GTPase; Region: YchF; cd01900
591946003703	G1 box; other site
591946003704	GTP/Mg2+ binding site [chemical binding]; other site
591946003705	Switch I region; other site
591946003706	G2 box; other site
591946003707	Switch II region; other site
591946003708	G3 box; other site
591946003709	G4 box; other site
591946003710	G5 box; other site
591946003711	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
591946003712	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
591946003713	putative active site [active]
591946003714	catalytic residue [active]
591946003715	hypothetical protein; Provisional; Region: PRK10692
591946003716	putative transporter; Provisional; Region: PRK11660
591946003717	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
591946003718	Sulfate transporter family; Region: Sulfate_transp; pfam00916
591946003719	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
591946003720	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
591946003721	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
591946003722	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591946003723	active site
591946003724	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
591946003725	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
591946003726	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
591946003727	outer membrane lipoprotein LolB; Region: lolB; TIGR00548
591946003728	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
591946003729	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
591946003730	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
591946003731	tRNA; other site
591946003732	putative tRNA binding site [nucleotide binding]; other site
591946003733	putative NADP binding site [chemical binding]; other site
591946003734	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
591946003735	peptide chain release factor 1; Validated; Region: prfA; PRK00591
591946003736	This domain is found in peptide chain release factors; Region: PCRF; smart00937
591946003737	RF-1 domain; Region: RF-1; pfam00472
591946003738	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
591946003739	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946003740	hypothetical protein; Provisional; Region: PRK10278
591946003741	hypothetical protein; Provisional; Region: PRK10941
591946003742	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
591946003743	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
591946003744	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
591946003745	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
591946003746	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
591946003747	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
591946003748	cation transport regulator; Reviewed; Region: chaB; PRK09582
591946003749	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
591946003750	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
591946003751	putative active site pocket [active]
591946003752	dimerization interface [polypeptide binding]; other site
591946003753	putative catalytic residue [active]
591946003754	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
591946003755	putative invasin; Provisional; Region: PRK10177
591946003756	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
591946003757	transcriptional regulator NarL; Provisional; Region: PRK10651
591946003758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946003759	active site
591946003760	phosphorylation site [posttranslational modification]
591946003761	intermolecular recognition site; other site
591946003762	dimerization interface [polypeptide binding]; other site
591946003763	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946003764	DNA binding residues [nucleotide binding]
591946003765	dimerization interface [polypeptide binding]; other site
591946003766	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
591946003767	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
591946003768	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591946003769	dimerization interface [polypeptide binding]; other site
591946003770	Histidine kinase; Region: HisKA_3; pfam07730
591946003771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946003772	ATP binding site [chemical binding]; other site
591946003773	Mg2+ binding site [ion binding]; other site
591946003774	G-X-G motif; other site
591946003775	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
591946003776	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
591946003777	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
591946003778	[4Fe-4S] binding site [ion binding]; other site
591946003779	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
591946003780	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
591946003781	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
591946003782	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
591946003783	molybdopterin cofactor binding site; other site
591946003784	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
591946003785	4Fe-4S binding domain; Region: Fer4; cl02805
591946003786	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
591946003787	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
591946003788	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
591946003789	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
591946003790	dimer interface [polypeptide binding]; other site
591946003791	active site
591946003792	CoA binding pocket [chemical binding]; other site
591946003793	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
591946003794	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591946003795	NAD(P) binding site [chemical binding]; other site
591946003796	active site
591946003797	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
591946003798	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
591946003799	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
591946003800	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
591946003801	active site
591946003802	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
591946003803	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
591946003804	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
591946003805	putative di-iron ligands [ion binding]; other site
591946003806	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
591946003807	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
591946003808	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
591946003809	putative active site [active]
591946003810	putative substrate binding site [chemical binding]; other site
591946003811	putative cosubstrate binding site; other site
591946003812	catalytic site [active]
591946003813	SEC-C motif; Region: SEC-C; pfam02810
591946003814	hypothetical protein; Provisional; Region: PRK04233
591946003815	hypothetical protein; Provisional; Region: PRK10279
591946003816	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
591946003817	active site
591946003818	nucleophile elbow; other site
591946003819	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946003820	active site
591946003821	response regulator of RpoS; Provisional; Region: PRK10693
591946003822	phosphorylation site [posttranslational modification]
591946003823	intermolecular recognition site; other site
591946003824	dimerization interface [polypeptide binding]; other site
591946003825	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
591946003826	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
591946003827	active site
591946003828	tetramer interface; other site
591946003829	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
591946003830	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
591946003831	thymidine kinase; Provisional; Region: PRK04296
591946003832	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591946003833	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591946003834	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591946003835	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
591946003836	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
591946003837	putative catalytic cysteine [active]
591946003838	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
591946003839	putative active site [active]
591946003840	metal binding site [ion binding]; metal-binding site
591946003841	hypothetical protein; Provisional; Region: PRK11111
591946003842	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
591946003843	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
591946003844	peptide binding site [polypeptide binding]; other site
591946003845	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
591946003846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946003847	dimer interface [polypeptide binding]; other site
591946003848	conserved gate region; other site
591946003849	putative PBP binding loops; other site
591946003850	ABC-ATPase subunit interface; other site
591946003851	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
591946003852	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
591946003853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946003854	dimer interface [polypeptide binding]; other site
591946003855	conserved gate region; other site
591946003856	putative PBP binding loops; other site
591946003857	ABC-ATPase subunit interface; other site
591946003858	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
591946003859	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946003860	Walker A/P-loop; other site
591946003861	ATP binding site [chemical binding]; other site
591946003862	Q-loop/lid; other site
591946003863	ABC transporter signature motif; other site
591946003864	Walker B; other site
591946003865	D-loop; other site
591946003866	H-loop/switch region; other site
591946003867	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
591946003868	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
591946003869	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946003870	Walker A/P-loop; other site
591946003871	ATP binding site [chemical binding]; other site
591946003872	Q-loop/lid; other site
591946003873	ABC transporter signature motif; other site
591946003874	Walker B; other site
591946003875	D-loop; other site
591946003876	H-loop/switch region; other site
591946003877	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
591946003878	dsDNA-mimic protein; Reviewed; Region: PRK05094
591946003879	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
591946003880	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
591946003881	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
591946003882	putative active site [active]
591946003883	catalytic site [active]
591946003884	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
591946003885	putative active site [active]
591946003886	catalytic site [active]
591946003887	voltage-gated potassium channel; Provisional; Region: PRK10537
591946003888	Ion channel; Region: Ion_trans_2; pfam07885
591946003889	TrkA-N domain; Region: TrkA_N; pfam02254
591946003890	YciI-like protein; Reviewed; Region: PRK11370
591946003891	transport protein TonB; Provisional; Region: PRK10819
591946003892	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
591946003893	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
591946003894	intracellular septation protein A; Reviewed; Region: PRK00259
591946003895	hypothetical protein; Provisional; Region: PRK02868
591946003896	outer membrane protein W; Provisional; Region: PRK10959
591946003897	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685
591946003898	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
591946003899	dimerization interface [polypeptide binding]; other site
591946003900	metal binding site [ion binding]; metal-binding site
591946003901	General stress protein [General function prediction only]; Region: GsiB; COG3729
591946003902	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
591946003903	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
591946003904	substrate binding site [chemical binding]; other site
591946003905	active site
591946003906	catalytic residues [active]
591946003907	heterodimer interface [polypeptide binding]; other site
591946003908	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
591946003909	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
591946003910	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946003911	catalytic residue [active]
591946003912	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
591946003913	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
591946003914	active site
591946003915	ribulose/triose binding site [chemical binding]; other site
591946003916	phosphate binding site [ion binding]; other site
591946003917	substrate (anthranilate) binding pocket [chemical binding]; other site
591946003918	product (indole) binding pocket [chemical binding]; other site
591946003919	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
591946003920	active site
591946003921	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
591946003922	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
591946003923	glutamine binding [chemical binding]; other site
591946003924	catalytic triad [active]
591946003925	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
591946003926	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
591946003927	anthranilate synthase component I; Provisional; Region: PRK13564
591946003928	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
591946003929	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
591946003930	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
591946003931	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
591946003932	active site
591946003933	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
591946003934	hypothetical protein; Provisional; Region: PRK11630
591946003935	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
591946003936	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
591946003937	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591946003938	RNA binding surface [nucleotide binding]; other site
591946003939	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
591946003940	probable active site [active]
591946003941	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
591946003942	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
591946003943	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
591946003944	homodimer interface [polypeptide binding]; other site
591946003945	Walker A motif; other site
591946003946	ATP binding site [chemical binding]; other site
591946003947	hydroxycobalamin binding site [chemical binding]; other site
591946003948	Walker B motif; other site
591946003949	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
591946003950	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
591946003951	NADP binding site [chemical binding]; other site
591946003952	homodimer interface [polypeptide binding]; other site
591946003953	active site
591946003954	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
591946003955	putative inner membrane peptidase; Provisional; Region: PRK11778
591946003956	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
591946003957	tandem repeat interface [polypeptide binding]; other site
591946003958	oligomer interface [polypeptide binding]; other site
591946003959	active site residues [active]
591946003960	hypothetical protein; Provisional; Region: PRK11037
591946003961	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
591946003962	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
591946003963	active site
591946003964	interdomain interaction site; other site
591946003965	putative metal-binding site [ion binding]; other site
591946003966	nucleotide binding site [chemical binding]; other site
591946003967	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
591946003968	domain I; other site
591946003969	DNA binding groove [nucleotide binding]
591946003970	phosphate binding site [ion binding]; other site
591946003971	domain II; other site
591946003972	domain III; other site
591946003973	nucleotide binding site [chemical binding]; other site
591946003974	catalytic site [active]
591946003975	domain IV; other site
591946003976	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
591946003977	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
591946003978	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
591946003979	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
591946003980	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
591946003981	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946003982	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
591946003983	substrate binding site [chemical binding]; other site
591946003984	putative dimerization interface [polypeptide binding]; other site
591946003985	aconitate hydratase; Validated; Region: PRK09277
591946003986	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
591946003987	substrate binding site [chemical binding]; other site
591946003988	ligand binding site [chemical binding]; other site
591946003989	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
591946003990	substrate binding site [chemical binding]; other site
591946003991	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
591946003992	dimerization interface [polypeptide binding]; other site
591946003993	active site
591946003994	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
591946003995	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
591946003996	active site
591946003997	Predicted membrane protein [Function unknown]; Region: COG3771
591946003998	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
591946003999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
591946004000	TPR motif; other site
591946004001	binding surface
591946004002	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591946004003	binding surface
591946004004	TPR motif; other site
591946004005	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
591946004006	active site
591946004007	dimer interface [polypeptide binding]; other site
591946004008	translation initiation factor Sui1; Validated; Region: PRK06824
591946004009	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
591946004010	putative rRNA binding site [nucleotide binding]; other site
591946004011	lipoprotein; Provisional; Region: PRK10540
591946004012	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591946004013	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
591946004014	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946004015	hypothetical protein; Provisional; Region: PRK13658
591946004016	RNase II stability modulator; Provisional; Region: PRK10060
591946004017	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591946004018	putative active site [active]
591946004019	heme pocket [chemical binding]; other site
591946004020	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946004021	metal binding site [ion binding]; metal-binding site
591946004022	active site
591946004023	I-site; other site
591946004024	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946004025	exoribonuclease II; Provisional; Region: PRK05054
591946004026	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
591946004027	RNB domain; Region: RNB; pfam00773
591946004028	S1 RNA binding domain; Region: S1; pfam00575
591946004029	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950
591946004030	Uncharacterized conserved protein [Function unknown]; Region: COG2128
591946004031	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
591946004032	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
591946004033	NAD binding site [chemical binding]; other site
591946004034	homotetramer interface [polypeptide binding]; other site
591946004035	homodimer interface [polypeptide binding]; other site
591946004036	substrate binding site [chemical binding]; other site
591946004037	active site
591946004038	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591946004039	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591946004040	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
591946004041	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946004042	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946004043	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
591946004044	Protein export membrane protein; Region: SecD_SecF; cl14618
591946004045	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
591946004046	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
591946004047	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946004048	putative substrate translocation pore; other site
591946004049	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
591946004050	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946004051	Walker A/P-loop; other site
591946004052	ATP binding site [chemical binding]; other site
591946004053	Q-loop/lid; other site
591946004054	ABC transporter signature motif; other site
591946004055	Walker B; other site
591946004056	D-loop; other site
591946004057	H-loop/switch region; other site
591946004058	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
591946004059	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946004060	Walker A/P-loop; other site
591946004061	ATP binding site [chemical binding]; other site
591946004062	Q-loop/lid; other site
591946004063	ABC transporter signature motif; other site
591946004064	Walker B; other site
591946004065	D-loop; other site
591946004066	H-loop/switch region; other site
591946004067	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
591946004068	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
591946004069	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
591946004070	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946004071	dimer interface [polypeptide binding]; other site
591946004072	conserved gate region; other site
591946004073	putative PBP binding loops; other site
591946004074	ABC-ATPase subunit interface; other site
591946004075	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
591946004076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946004077	dimer interface [polypeptide binding]; other site
591946004078	conserved gate region; other site
591946004079	putative PBP binding loops; other site
591946004080	ABC-ATPase subunit interface; other site
591946004081	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
591946004082	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
591946004083	peptide binding site [polypeptide binding]; other site
591946004084	Protein of unknown function (DUF2543); Region: DUF2543; pfam10820
591946004085	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
591946004086	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946004087	Walker A motif; other site
591946004088	ATP binding site [chemical binding]; other site
591946004089	Walker B motif; other site
591946004090	arginine finger; other site
591946004091	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
591946004092	phage shock protein PspA; Provisional; Region: PRK10698
591946004093	phage shock protein B; Provisional; Region: pspB; PRK09458
591946004094	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
591946004095	phage shock protein C; Region: phageshock_pspC; TIGR02978
591946004096	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
591946004097	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
591946004098	active site residue [active]
591946004099	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
591946004100	sucrose phosphorylase; Provisional; Region: PRK13840
591946004101	active site
591946004102	homodimer interface [polypeptide binding]; other site
591946004103	catalytic site [active]
591946004104	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
591946004105	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
591946004106	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
591946004107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946004108	dimer interface [polypeptide binding]; other site
591946004109	conserved gate region; other site
591946004110	putative PBP binding loops; other site
591946004111	ABC-ATPase subunit interface; other site
591946004112	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
591946004113	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946004114	dimer interface [polypeptide binding]; other site
591946004115	conserved gate region; other site
591946004116	putative PBP binding loops; other site
591946004117	ABC-ATPase subunit interface; other site
591946004118	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591946004119	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
591946004120	putative NAD(P) binding site [chemical binding]; other site
591946004121	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
591946004122	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
591946004123	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
591946004124	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
591946004125	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
591946004126	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
591946004127	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
591946004128	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
591946004129	beta-phosphoglucomutase; Region: bPGM; TIGR01990
591946004130	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946004131	motif II; other site
591946004132	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
591946004133	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
591946004134	Walker A/P-loop; other site
591946004135	ATP binding site [chemical binding]; other site
591946004136	Q-loop/lid; other site
591946004137	ABC transporter signature motif; other site
591946004138	Walker B; other site
591946004139	D-loop; other site
591946004140	H-loop/switch region; other site
591946004141	TOBE domain; Region: TOBE_2; pfam08402
591946004142	Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381
591946004143	Transcriptional regulators [Transcription]; Region: PurR; COG1609
591946004144	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946004145	DNA binding site [nucleotide binding]
591946004146	domain linker motif; other site
591946004147	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
591946004148	putative dimerization interface [polypeptide binding]; other site
591946004149	putative ligand binding site [chemical binding]; other site
591946004150	Predicted ATPase [General function prediction only]; Region: COG3106
591946004151	hypothetical protein; Provisional; Region: PRK05415
591946004152	TIGR01620 family protein; Region: hyp_HI0043
591946004153	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
591946004154	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
591946004155	putative aromatic amino acid binding site; other site
591946004156	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946004157	Walker A motif; other site
591946004158	ATP binding site [chemical binding]; other site
591946004159	Walker B motif; other site
591946004160	arginine finger; other site
591946004161	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
591946004162	dimer interface [polypeptide binding]; other site
591946004163	catalytic triad [active]
591946004164	peroxidatic and resolving cysteines [active]
591946004165	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
591946004166	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
591946004167	active site
591946004168	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
591946004169	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
591946004170	putative active site [active]
591946004171	Zn binding site [ion binding]; other site
591946004172	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
591946004173	NADH(P)-binding; Region: NAD_binding_10; pfam13460
591946004174	putative NAD(P) binding site [chemical binding]; other site
591946004175	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
591946004176	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
591946004177	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591946004178	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946004179	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
591946004180	putative effector binding pocket; other site
591946004181	putative dimerization interface [polypeptide binding]; other site
591946004182	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
591946004183	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
591946004184	peptide binding site [polypeptide binding]; other site
591946004185	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
591946004186	Mechanosensitive ion channel; Region: MS_channel; pfam00924
591946004187	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
591946004188	universal stress protein UspE; Provisional; Region: PRK11175
591946004189	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591946004190	Ligand Binding Site [chemical binding]; other site
591946004191	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591946004192	Ligand Binding Site [chemical binding]; other site
591946004193	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
591946004194	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
591946004195	ligand binding site [chemical binding]; other site
591946004196	flexible hinge region; other site
591946004197	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
591946004198	putative switch regulator; other site
591946004199	non-specific DNA interactions [nucleotide binding]; other site
591946004200	DNA binding site [nucleotide binding]
591946004201	sequence specific DNA binding site [nucleotide binding]; other site
591946004202	putative cAMP binding site [chemical binding]; other site
591946004203	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
591946004204	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
591946004205	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
591946004206	DNA binding site [nucleotide binding]
591946004207	active site
591946004208	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15356
591946004209	Cupin domain; Region: Cupin_2; cl17218
591946004210	Helix-turn-helix domain; Region: HTH_18; pfam12833
591946004211	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946004212	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
591946004213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
591946004214	Smr domain; Region: Smr; pfam01713
591946004215	PAS domain S-box; Region: sensory_box; TIGR00229
591946004216	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591946004217	putative active site [active]
591946004218	heme pocket [chemical binding]; other site
591946004219	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591946004220	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946004221	metal binding site [ion binding]; metal-binding site
591946004222	active site
591946004223	I-site; other site
591946004224	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
591946004225	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
591946004226	Cl binding site [ion binding]; other site
591946004227	oligomer interface [polypeptide binding]; other site
591946004228	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
591946004229	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
591946004230	ATP binding site [chemical binding]; other site
591946004231	Mg++ binding site [ion binding]; other site
591946004232	motif III; other site
591946004233	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591946004234	nucleotide binding region [chemical binding]; other site
591946004235	ATP-binding site [chemical binding]; other site
591946004236	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
591946004237	putative RNA binding site [nucleotide binding]; other site
591946004238	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
591946004239	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
591946004240	Ligand Binding Site [chemical binding]; other site
591946004241	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591946004242	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
591946004243	DNA binding site [nucleotide binding]
591946004244	active site
591946004245	Int/Topo IB signature motif; other site
591946004246	536; APEC_01; CFT073; ED1a; E2348; S88; UTI89
591946004247	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591946004248	Ligand Binding Site [chemical binding]; other site
591946004249	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591946004250	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591946004251	trimer interface [polypeptide binding]; other site
591946004252	eyelet of channel; other site
591946004253	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
591946004254	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
591946004255	dimer interface [polypeptide binding]; other site
591946004256	PYR/PP interface [polypeptide binding]; other site
591946004257	TPP binding site [chemical binding]; other site
591946004258	substrate binding site [chemical binding]; other site
591946004259	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
591946004260	Domain of unknown function; Region: EKR; smart00890
591946004261	4Fe-4S binding domain; Region: Fer4_6; pfam12837
591946004262	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591946004263	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
591946004264	TPP-binding site [chemical binding]; other site
591946004265	dimer interface [polypeptide binding]; other site
591946004266	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
591946004267	Domain of unknown function (DUF333); Region: DUF333; pfam03891
591946004268	heat-inducible protein; Provisional; Region: PRK10449
591946004269	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
591946004270	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
591946004271	putative ligand binding site [chemical binding]; other site
591946004272	putative NAD binding site [chemical binding]; other site
591946004273	catalytic site [active]
591946004274	hypothetical protein; Provisional; Region: PRK10695
591946004275	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
591946004276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
591946004277	Autotransporter beta-domain; Region: Autotransporter; pfam03797
591946004278	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591946004279	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591946004280	active site
591946004281	catalytic tetrad [active]
591946004282	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
591946004283	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
591946004284	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
591946004285	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
591946004286	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
591946004287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946004288	S-adenosylmethionine binding site [chemical binding]; other site
591946004289	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
591946004290	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
591946004291	active site
591946004292	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
591946004293	active site
591946004294	catalytic residues [active]
591946004295	azoreductase; Reviewed; Region: PRK00170
591946004296	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
591946004297	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
591946004298	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591946004299	ATP binding site [chemical binding]; other site
591946004300	putative Mg++ binding site [ion binding]; other site
591946004301	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591946004302	nucleotide binding region [chemical binding]; other site
591946004303	ATP-binding site [chemical binding]; other site
591946004304	Helicase associated domain (HA2); Region: HA2; pfam04408
591946004305	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
591946004306	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
591946004307	Uncharacterized conserved protein [Function unknown]; Region: COG1434
591946004308	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
591946004309	putative active site [active]
591946004310	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
591946004311	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
591946004312	NAD binding site [chemical binding]; other site
591946004313	catalytic residues [active]
591946004314	substrate binding site [chemical binding]; other site
591946004315	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
591946004316	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
591946004317	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
591946004318	cytochrome b561; Provisional; Region: PRK11513
591946004319	hypothetical protein; Provisional; Region: PRK10040
591946004320	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
591946004321	dimer interface [polypeptide binding]; other site
591946004322	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
591946004323	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946004324	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591946004325	dimerization interface [polypeptide binding]; other site
591946004326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
591946004327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
591946004328	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
591946004329	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
591946004330	hypothetical protein; Provisional; Region: PRK11415
591946004331	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
591946004332	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946004333	Coenzyme A binding pocket [chemical binding]; other site
591946004334	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
591946004335	putative trimer interface [polypeptide binding]; other site
591946004336	putative CoA binding site [chemical binding]; other site
591946004337	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
591946004338	putative trimer interface [polypeptide binding]; other site
591946004339	putative CoA binding site [chemical binding]; other site
591946004340	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
591946004341	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
591946004342	gating phenylalanine in ion channel; other site
591946004343	tellurite resistance protein TehB; Provisional; Region: PRK11207
591946004344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946004345	S-adenosylmethionine binding site [chemical binding]; other site
591946004346	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
591946004347	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
591946004348	benzoate transporter; Region: benE; TIGR00843
591946004349	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
591946004350	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946004351	non-specific DNA binding site [nucleotide binding]; other site
591946004352	salt bridge; other site
591946004353	sequence-specific DNA binding site [nucleotide binding]; other site
591946004354	Cupin domain; Region: Cupin_2; pfam07883
591946004355	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
591946004356	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
591946004357	Peptidase family U32; Region: Peptidase_U32; pfam01136
591946004358	Collagenase; Region: DUF3656; pfam12392
591946004359	Protein of unknown function (DUF2554); Region: DUF2554; pfam10829
591946004360	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
591946004361	sequence-specific DNA binding site [nucleotide binding]; other site
591946004362	salt bridge; other site
591946004363	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
591946004364	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946004365	DNA-binding site [nucleotide binding]; DNA binding site
591946004366	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591946004367	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946004368	homodimer interface [polypeptide binding]; other site
591946004369	catalytic residue [active]
591946004370	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
591946004371	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
591946004372	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
591946004373	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946004374	Walker A/P-loop; other site
591946004375	ATP binding site [chemical binding]; other site
591946004376	Q-loop/lid; other site
591946004377	ABC transporter signature motif; other site
591946004378	Walker B; other site
591946004379	D-loop; other site
591946004380	H-loop/switch region; other site
591946004381	TOBE domain; Region: TOBE_2; pfam08402
591946004382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946004383	dimer interface [polypeptide binding]; other site
591946004384	conserved gate region; other site
591946004385	putative PBP binding loops; other site
591946004386	ABC-ATPase subunit interface; other site
591946004387	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
591946004388	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946004389	ABC-ATPase subunit interface; other site
591946004390	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
591946004391	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
591946004392	tetrameric interface [polypeptide binding]; other site
591946004393	NAD binding site [chemical binding]; other site
591946004394	catalytic residues [active]
591946004395	substrate binding site [chemical binding]; other site
591946004396	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
591946004397	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
591946004398	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
591946004399	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
591946004400	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
591946004401	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
591946004402	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
591946004403	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591946004404	N-terminal plug; other site
591946004405	ligand-binding site [chemical binding]; other site
591946004406	PQQ-like domain; Region: PQQ_2; pfam13360
591946004407	L-asparagine permease; Provisional; Region: PRK15049
591946004408	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
591946004409	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
591946004410	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
591946004411	dimer interface [polypeptide binding]; other site
591946004412	N-terminal domain interface [polypeptide binding]; other site
591946004413	substrate binding pocket (H-site) [chemical binding]; other site
591946004414	PAAR motif; Region: PAAR_motif; pfam05488
591946004415	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
591946004416	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
591946004417	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
591946004418	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
591946004419	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
591946004420	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
591946004421	potential frameshift: common BLAST hit: gi|110642861|ref|YP_670591.1| transposase
591946004422	Winged helix-turn helix; Region: HTH_33; pfam13592
591946004423	DDE superfamily endonuclease; Region: DDE_3; pfam13358
591946004424	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
591946004425	Homeodomain-like domain; Region: HTH_23; pfam13384
591946004426	Winged helix-turn helix; Region: HTH_29; pfam13551
591946004427	Transposase [DNA replication, recombination, and repair]; Region: COG5433
591946004428	PAAR motif; Region: PAAR_motif; pfam05488
591946004429	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
591946004430	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
591946004431	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
591946004432	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
591946004433	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
591946004434	Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007
591946004435	putative active site [active]
591946004436	putative Zn binding site [ion binding]; other site
591946004437	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
591946004438	N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047
591946004439	hypothetical protein; Provisional; Region: PRK10281
591946004440	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
591946004441	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
591946004442	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
591946004443	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
591946004444	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
591946004445	[4Fe-4S] binding site [ion binding]; other site
591946004446	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
591946004447	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
591946004448	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
591946004449	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
591946004450	molybdopterin cofactor binding site; other site
591946004451	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
591946004452	aromatic amino acid exporter; Provisional; Region: PRK11689
591946004453	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
591946004454	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
591946004455	[4Fe-4S] binding site [ion binding]; other site
591946004456	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
591946004457	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
591946004458	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
591946004459	molybdopterin cofactor binding site; other site
591946004460	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
591946004461	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
591946004462	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
591946004463	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
591946004464	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
591946004465	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946004466	non-specific DNA binding site [nucleotide binding]; other site
591946004467	salt bridge; other site
591946004468	sequence-specific DNA binding site [nucleotide binding]; other site
591946004469	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
591946004470	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
591946004471	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
591946004472	NAD binding site [chemical binding]; other site
591946004473	substrate binding site [chemical binding]; other site
591946004474	catalytic Zn binding site [ion binding]; other site
591946004475	tetramer interface [polypeptide binding]; other site
591946004476	structural Zn binding site [ion binding]; other site
591946004477	malate dehydrogenase; Provisional; Region: PRK13529
591946004478	Malic enzyme, N-terminal domain; Region: malic; pfam00390
591946004479	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
591946004480	NAD(P) binding site [chemical binding]; other site
591946004481	30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057
591946004482	Putative biofilm-dependent modulation protein; Region: BDM; cl11581
591946004483	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
591946004484	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
591946004485	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591946004486	putative active site [active]
591946004487	heme pocket [chemical binding]; other site
591946004488	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591946004489	putative active site [active]
591946004490	heme pocket [chemical binding]; other site
591946004491	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946004492	metal binding site [ion binding]; metal-binding site
591946004493	active site
591946004494	I-site; other site
591946004495	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946004496	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591946004497	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946004498	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
591946004499	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
591946004500	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
591946004501	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
591946004502	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946004503	catalytic residue [active]
591946004504	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
591946004505	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
591946004506	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946004507	FeS/SAM binding site; other site
591946004508	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
591946004509	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
591946004510	Sulfatase; Region: Sulfatase; pfam00884
591946004511	transcriptional regulator YdeO; Provisional; Region: PRK09940
591946004512	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946004513	putative oxidoreductase; Provisional; Region: PRK09939
591946004514	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
591946004515	putative molybdopterin cofactor binding site [chemical binding]; other site
591946004516	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
591946004517	putative molybdopterin cofactor binding site; other site
591946004518	Mannose binding  domain of FimH and related proteins; Region: FimH_man-bind; cd10466
591946004519	mannosyl binding site [chemical binding]; other site
591946004520	Fimbrial protein; Region: Fimbrial; pfam00419
591946004521	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591946004522	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591946004523	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
591946004524	PapC N-terminal domain; Region: PapC_N; pfam13954
591946004525	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591946004526	PapC C-terminal domain; Region: PapC_C; pfam13953
591946004527	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
591946004528	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591946004529	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591946004530	Fimbrial protein; Region: Fimbrial; cl01416
591946004531	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
591946004532	NADH(P)-binding; Region: NAD_binding_10; pfam13460
591946004533	NAD(P) binding site [chemical binding]; other site
591946004534	putative active site [active]
591946004535	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591946004536	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946004537	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
591946004538	putative effector binding pocket; other site
591946004539	putative dimerization interface [polypeptide binding]; other site
591946004540	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
591946004541	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
591946004542	catalytic site [active]
591946004543	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
591946004544	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
591946004545	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
591946004546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946004547	intermolecular recognition site; other site
591946004548	active site
591946004549	dimerization interface [polypeptide binding]; other site
591946004550	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946004551	DNA binding site [nucleotide binding]
591946004552	HipA N-terminal domain; Region: Couple_hipA; pfam13657
591946004553	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
591946004554	HipA-like N-terminal domain; Region: HipA_N; pfam07805
591946004555	HipA-like C-terminal domain; Region: HipA_C; pfam07804
591946004556	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
591946004557	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946004558	non-specific DNA binding site [nucleotide binding]; other site
591946004559	salt bridge; other site
591946004560	sequence-specific DNA binding site [nucleotide binding]; other site
591946004561	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
591946004562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946004563	S-adenosylmethionine binding site [chemical binding]; other site
591946004564	Predicted membrane protein [Function unknown]; Region: COG3781
591946004565	altronate oxidoreductase; Provisional; Region: PRK03643
591946004566	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
591946004567	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
591946004568	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591946004569	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946004570	metal binding site [ion binding]; metal-binding site
591946004571	active site
591946004572	I-site; other site
591946004573	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
591946004574	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
591946004575	glutaminase; Provisional; Region: PRK00971
591946004576	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
591946004577	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
591946004578	NAD(P) binding site [chemical binding]; other site
591946004579	catalytic residues [active]
591946004580	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591946004581	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946004582	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
591946004583	putative dimerization interface [polypeptide binding]; other site
591946004584	putative arabinose transporter; Provisional; Region: PRK03545
591946004585	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946004586	putative substrate translocation pore; other site
591946004587	inner membrane protein; Provisional; Region: PRK10995
591946004588	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
591946004589	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
591946004590	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
591946004591	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946004592	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946004593	hypothetical protein; Provisional; Region: PRK10106
591946004594	6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589
591946004595	beta-galactosidase; Region: BGL; TIGR03356
591946004596	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
591946004597	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
591946004598	trimer interface; other site
591946004599	sugar binding site [chemical binding]; other site
591946004600	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
591946004601	active site
591946004602	methionine cluster; other site
591946004603	phosphorylation site [posttranslational modification]
591946004604	metal binding site [ion binding]; metal-binding site
591946004605	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
591946004606	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
591946004607	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
591946004608	active site
591946004609	P-loop; other site
591946004610	phosphorylation site [posttranslational modification]
591946004611	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
591946004612	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946004613	DNA-binding site [nucleotide binding]; DNA binding site
591946004614	UTRA domain; Region: UTRA; pfam07702
591946004615	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
591946004616	EamA-like transporter family; Region: EamA; pfam00892
591946004617	EamA-like transporter family; Region: EamA; pfam00892
591946004618	putative transporter; Provisional; Region: PRK10054
591946004619	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946004620	putative substrate translocation pore; other site
591946004621	diguanylate cyclase; Provisional; Region: PRK09894
591946004622	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
591946004623	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946004624	metal binding site [ion binding]; metal-binding site
591946004625	active site
591946004626	I-site; other site
591946004627	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
591946004628	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
591946004629	active site
591946004630	Zn binding site [ion binding]; other site
591946004631	malonic semialdehyde reductase; Provisional; Region: PRK10538
591946004632	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
591946004633	putative NAD(P) binding site [chemical binding]; other site
591946004634	homodimer interface [polypeptide binding]; other site
591946004635	homotetramer interface [polypeptide binding]; other site
591946004636	active site
591946004637	Transcriptional regulators [Transcription]; Region: GntR; COG1802
591946004638	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946004639	DNA-binding site [nucleotide binding]; DNA binding site
591946004640	FCD domain; Region: FCD; pfam07729
591946004641	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
591946004642	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
591946004643	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
591946004644	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
591946004645	metabolite-proton symporter; Region: 2A0106; TIGR00883
591946004646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946004647	putative substrate translocation pore; other site
591946004648	multiple promoter invertase; Provisional; Region: mpi; PRK13413
591946004649	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
591946004650	catalytic residues [active]
591946004651	catalytic nucleophile [active]
591946004652	Presynaptic Site I dimer interface [polypeptide binding]; other site
591946004653	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
591946004654	Synaptic Flat tetramer interface [polypeptide binding]; other site
591946004655	Synaptic Site I dimer interface [polypeptide binding]; other site
591946004656	DNA binding site [nucleotide binding]
591946004657	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
591946004658	DNA-binding interface [nucleotide binding]; DNA binding site
591946004659	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
591946004660	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
591946004661	Phage-related protein, tail component [Function unknown]; Region: COG4733
591946004662	Putative phage tail protein; Region: Phage-tail_3; pfam13550
591946004663	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
591946004664	Fibronectin type III protein; Region: DUF3672; pfam12421
591946004665	Phage-related protein, tail component [Function unknown]; Region: COG4723
591946004666	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
591946004667	MPN+ (JAMM) motif; other site
591946004668	Zinc-binding site [ion binding]; other site
591946004669	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
591946004670	NlpC/P60 family; Region: NLPC_P60; cl17555
591946004671	Phage-related protein [Function unknown]; Region: gp18; COG4672
591946004672	Phage-related protein [Function unknown]; Region: COG4718
591946004673	Phage-related minor tail protein [Function unknown]; Region: COG5281
591946004674	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
591946004675	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
591946004676	Minor tail protein T; Region: Phage_tail_T; pfam06223
591946004677	phage minor tail protein G; Region: phage_lambda_G; TIGR01674
591946004678	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
591946004679	Bacterial Ig-like domain 2; Region: BID_2; smart00635
591946004680	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
591946004681	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
591946004682	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856
591946004683	Uncharacterized conserved protein [Function unknown]; Region: COG5471
591946004684	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
591946004685	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
591946004686	oligomer interface [polypeptide binding]; other site
591946004687	active site residues [active]
591946004688	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
591946004689	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
591946004690	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
591946004691	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
591946004692	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
591946004693	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
591946004694	GnsA/GnsB family; Region: GnsAB; pfam08178
591946004695	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591946004696	DNA-binding site [nucleotide binding]; DNA binding site
591946004697	RNA-binding motif; other site
591946004698	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
591946004699	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
591946004700	catalytic residues [active]
591946004701	Protein of unknown function (DUF1327); Region: DUF1327; pfam07041
591946004702	Lysis protein S; Region: Lysis_S; pfam04971
591946004703	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591946004704	DNA-binding site [nucleotide binding]; DNA binding site
591946004705	RNA-binding motif; other site
591946004706	Antitermination protein; Region: Antiterm; pfam03589
591946004707	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
591946004708	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
591946004709	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
591946004710	Protein of unknown function (DUF968); Region: DUF968; pfam06147
591946004711	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
591946004712	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946004713	non-specific DNA binding site [nucleotide binding]; other site
591946004714	salt bridge; other site
591946004715	sequence-specific DNA binding site [nucleotide binding]; other site
591946004716	Domain of unknown function (DUF955); Region: DUF955; cl01076
591946004717	Hok/gef family; Region: HOK_GEF; pfam01848
591946004718	This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901
591946004719	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
591946004720	primosomal protein DnaI; Provisional; Region: PRK02854
591946004721	Protein of unknown function (DUF1019); Region: DUF1019; pfam06254
591946004722	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946004723	non-specific DNA binding site [nucleotide binding]; other site
591946004724	salt bridge; other site
591946004725	transcriptional repressor DicA; Reviewed; Region: PRK09706
591946004726	sequence-specific DNA binding site [nucleotide binding]; other site
591946004727	Protein of unknown function (DUF1391); Region: DUF1391; pfam07151
591946004728	DicB protein; Region: DicB; pfam05358
591946004729	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
591946004730	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
591946004731	active site
591946004732	catalytic site [active]
591946004733	substrate binding site [chemical binding]; other site
591946004734	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
591946004735	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
591946004736	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
591946004737	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
591946004738	Int/Topo IB signature motif; other site
591946004739	putative oxidoreductase; Provisional; Region: PRK10083
591946004740	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
591946004741	putative NAD(P) binding site [chemical binding]; other site
591946004742	catalytic Zn binding site [ion binding]; other site
591946004743	structural Zn binding site [ion binding]; other site
591946004744	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
591946004745	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
591946004746	putative active site pocket [active]
591946004747	putative metal binding site [ion binding]; other site
591946004748	hypothetical protein; Provisional; Region: PRK02237
591946004749	hypothetical protein; Provisional; Region: PRK13659
591946004750	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
591946004751	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946004752	Coenzyme A binding pocket [chemical binding]; other site
591946004753	Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788
591946004754	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
591946004755	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
591946004756	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
591946004757	putative [Fe4-S4] binding site [ion binding]; other site
591946004758	putative molybdopterin cofactor binding site [chemical binding]; other site
591946004759	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
591946004760	putative molybdopterin cofactor binding site; other site
591946004761	dimethyl sulfoxide reductase chain ynfF
591946004762	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
591946004763	4Fe-4S binding domain; Region: Fer4; cl02805
591946004764	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
591946004765	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
591946004766	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
591946004767	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
591946004768	Cl- selectivity filter; other site
591946004769	Cl- binding residues [ion binding]; other site
591946004770	pore gating glutamate residue; other site
591946004771	dimer interface [polypeptide binding]; other site
591946004772	putative dithiobiotin synthetase; Provisional; Region: PRK12374
591946004773	AAA domain; Region: AAA_26; pfam13500
591946004774	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
591946004775	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
591946004776	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591946004777	nucleotide binding site [chemical binding]; other site
591946004778	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
591946004779	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946004780	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
591946004781	dimerization interface [polypeptide binding]; other site
591946004782	substrate binding pocket [chemical binding]; other site
591946004783	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
591946004784	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946004785	putative substrate translocation pore; other site
591946004786	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
591946004787	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
591946004788	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
591946004789	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
591946004790	Domain of unknown function DUF20; Region: UPF0118; pfam01594
591946004791	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
591946004792	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
591946004793	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
591946004794	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
591946004795	ligand binding site [chemical binding]; other site
591946004796	homodimer interface [polypeptide binding]; other site
591946004797	NAD(P) binding site [chemical binding]; other site
591946004798	trimer interface B [polypeptide binding]; other site
591946004799	trimer interface A [polypeptide binding]; other site
591946004800	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
591946004801	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591946004802	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591946004803	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591946004804	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
591946004805	Spore germination protein; Region: Spore_permease; cl17796
591946004806	dihydromonapterin reductase; Provisional; Region: PRK06483
591946004807	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
591946004808	NADP binding site [chemical binding]; other site
591946004809	substrate binding pocket [chemical binding]; other site
591946004810	active site
591946004811	GlpM protein; Region: GlpM; pfam06942
591946004812	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
591946004813	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946004814	active site
591946004815	phosphorylation site [posttranslational modification]
591946004816	intermolecular recognition site; other site
591946004817	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946004818	DNA binding site [nucleotide binding]
591946004819	sensor protein RstB; Provisional; Region: PRK10604
591946004820	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591946004821	dimerization interface [polypeptide binding]; other site
591946004822	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946004823	dimer interface [polypeptide binding]; other site
591946004824	phosphorylation site [posttranslational modification]
591946004825	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946004826	ATP binding site [chemical binding]; other site
591946004827	Mg2+ binding site [ion binding]; other site
591946004828	G-X-G motif; other site
591946004829	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
591946004830	fumarate hydratase; Reviewed; Region: fumC; PRK00485
591946004831	Class II fumarases; Region: Fumarase_classII; cd01362
591946004832	active site
591946004833	tetramer interface [polypeptide binding]; other site
591946004834	fumarate hydratase; Provisional; Region: PRK15389
591946004835	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
591946004836	Fumarase C-terminus; Region: Fumerase_C; pfam05683
591946004837	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
591946004838	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
591946004839	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
591946004840	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
591946004841	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
591946004842	putative outer membrane porin protein; Provisional; Region: PRK11379
591946004843	glucuronide transporter; Provisional; Region: PRK09848
591946004844	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
591946004845	beta-D-glucuronidase; Provisional; Region: PRK10150
591946004846	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
591946004847	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
591946004848	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
591946004849	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591946004850	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591946004851	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
591946004852	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
591946004853	NAD binding site [chemical binding]; other site
591946004854	substrate binding site [chemical binding]; other site
591946004855	homotetramer interface [polypeptide binding]; other site
591946004856	homodimer interface [polypeptide binding]; other site
591946004857	active site
591946004858	DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014
591946004859	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946004860	DNA binding site [nucleotide binding]
591946004861	domain linker motif; other site
591946004862	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
591946004863	putative dimerization interface [polypeptide binding]; other site
591946004864	putative ligand binding site [chemical binding]; other site
591946004865	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
591946004866	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
591946004867	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591946004868	active site turn [active]
591946004869	phosphorylation site [posttranslational modification]
591946004870	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
591946004871	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591946004872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946004873	homodimer interface [polypeptide binding]; other site
591946004874	catalytic residue [active]
591946004875	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
591946004876	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
591946004877	active site
591946004878	purine riboside binding site [chemical binding]; other site
591946004879	putative oxidoreductase; Provisional; Region: PRK11579
591946004880	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
591946004881	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
591946004882	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
591946004883	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
591946004884	electron transport complex protein RsxA; Provisional; Region: PRK05151
591946004885	electron transport complex protein RnfB; Provisional; Region: PRK05113
591946004886	Putative Fe-S cluster; Region: FeS; pfam04060
591946004887	4Fe-4S binding domain; Region: Fer4; pfam00037
591946004888	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
591946004889	SLBB domain; Region: SLBB; pfam10531
591946004890	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591946004891	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
591946004892	electron transport complex protein RnfG; Validated; Region: PRK01908
591946004893	electron transport complex RsxE subunit; Provisional; Region: PRK12405
591946004894	endonuclease III; Provisional; Region: PRK10702
591946004895	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
591946004896	minor groove reading motif; other site
591946004897	helix-hairpin-helix signature motif; other site
591946004898	substrate binding pocket [chemical binding]; other site
591946004899	active site
591946004900	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
591946004901	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
591946004902	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946004903	putative substrate translocation pore; other site
591946004904	POT family; Region: PTR2; pfam00854
591946004905	glutathionine S-transferase; Provisional; Region: PRK10542
591946004906	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
591946004907	C-terminal domain interface [polypeptide binding]; other site
591946004908	GSH binding site (G-site) [chemical binding]; other site
591946004909	dimer interface [polypeptide binding]; other site
591946004910	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
591946004911	N-terminal domain interface [polypeptide binding]; other site
591946004912	dimer interface [polypeptide binding]; other site
591946004913	substrate binding pocket (H-site) [chemical binding]; other site
591946004914	pyridoxamine kinase; Validated; Region: PRK05756
591946004915	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
591946004916	dimer interface [polypeptide binding]; other site
591946004917	pyridoxal binding site [chemical binding]; other site
591946004918	ATP binding site [chemical binding]; other site
591946004919	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
591946004920	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
591946004921	active site
591946004922	HIGH motif; other site
591946004923	dimer interface [polypeptide binding]; other site
591946004924	KMSKS motif; other site
591946004925	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591946004926	RNA binding surface [nucleotide binding]; other site
591946004927	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
591946004928	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
591946004929	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
591946004930	lysozyme inhibitor; Provisional; Region: PRK11372
591946004931	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
591946004932	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
591946004933	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
591946004934	transcriptional regulator SlyA; Provisional; Region: PRK03573
591946004935	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
591946004936	Protein of unknown function (DUF1656); Region: DUF1656; cl11658
591946004937	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
591946004938	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946004939	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946004940	Fusaric acid resistance protein family; Region: FUSC; pfam04632
591946004941	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
591946004942	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
591946004943	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
591946004944	E-class dimer interface [polypeptide binding]; other site
591946004945	P-class dimer interface [polypeptide binding]; other site
591946004946	active site
591946004947	Cu2+ binding site [ion binding]; other site
591946004948	Zn2+ binding site [ion binding]; other site
591946004949	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591946004950	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591946004951	active site
591946004952	catalytic tetrad [active]
591946004953	Predicted Fe-S protein [General function prediction only]; Region: COG3313
591946004954	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591946004955	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591946004956	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
591946004957	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
591946004958	FMN binding site [chemical binding]; other site
591946004959	active site
591946004960	substrate binding site [chemical binding]; other site
591946004961	catalytic residue [active]
591946004962	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
591946004963	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
591946004964	dimer interface [polypeptide binding]; other site
591946004965	active site
591946004966	metal binding site [ion binding]; metal-binding site
591946004967	glutathione binding site [chemical binding]; other site
591946004968	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
591946004969	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
591946004970	dimer interface [polypeptide binding]; other site
591946004971	catalytic site [active]
591946004972	putative active site [active]
591946004973	putative substrate binding site [chemical binding]; other site
591946004974	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
591946004975	putative GSH binding site [chemical binding]; other site
591946004976	catalytic residues [active]
591946004977	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
591946004978	NlpC/P60 family; Region: NLPC_P60; pfam00877
591946004979	superoxide dismutase; Provisional; Region: PRK10543
591946004980	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
591946004981	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
591946004982	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946004983	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591946004984	putative substrate translocation pore; other site
591946004985	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
591946004986	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946004987	DNA binding site [nucleotide binding]
591946004988	domain linker motif; other site
591946004989	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
591946004990	dimerization interface [polypeptide binding]; other site
591946004991	ligand binding site [chemical binding]; other site
591946004992	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
591946004993	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946004994	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591946004995	dimerization interface [polypeptide binding]; other site
591946004996	putative transporter; Provisional; Region: PRK11043
591946004997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946004998	putative substrate translocation pore; other site
591946004999	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
591946005000	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
591946005001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946005002	S-adenosylmethionine binding site [chemical binding]; other site
591946005003	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
591946005004	Lumazine binding domain; Region: Lum_binding; pfam00677
591946005005	Lumazine binding domain; Region: Lum_binding; pfam00677
591946005006	multidrug efflux protein; Reviewed; Region: PRK01766
591946005007	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
591946005008	cation binding site [ion binding]; other site
591946005009	hypothetical protein; Provisional; Region: PRK09945
591946005010	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
591946005011	putative monooxygenase; Provisional; Region: PRK11118
591946005012	hypothetical protein; Provisional; Region: PRK09897
591946005013	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
591946005014	hypothetical protein; Provisional; Region: PRK09946
591946005015	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
591946005016	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
591946005017	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
591946005018	hypothetical protein; Provisional; Region: PRK09947
591946005019	putative oxidoreductase; Provisional; Region: PRK09849
591946005020	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
591946005021	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
591946005022	hypothetical protein; Provisional; Region: PRK09898
591946005023	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591946005024	hypothetical protein; Provisional; Region: PRK10292
591946005025	pyruvate kinase; Provisional; Region: PRK09206
591946005026	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
591946005027	domain interfaces; other site
591946005028	active site
591946005029	murein lipoprotein; Provisional; Region: PRK15396
591946005030	L,D-transpeptidase; Provisional; Region: PRK10190
591946005031	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591946005032	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591946005033	cysteine desufuration protein SufE; Provisional; Region: PRK09296
591946005034	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
591946005035	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
591946005036	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591946005037	catalytic residue [active]
591946005038	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
591946005039	FeS assembly protein SufD; Region: sufD; TIGR01981
591946005040	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
591946005041	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
591946005042	Walker A/P-loop; other site
591946005043	ATP binding site [chemical binding]; other site
591946005044	Q-loop/lid; other site
591946005045	ABC transporter signature motif; other site
591946005046	Walker B; other site
591946005047	D-loop; other site
591946005048	H-loop/switch region; other site
591946005049	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
591946005050	putative ABC transporter; Region: ycf24; CHL00085
591946005051	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
591946005052	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
591946005053	CoenzymeA binding site [chemical binding]; other site
591946005054	subunit interaction site [polypeptide binding]; other site
591946005055	PHB binding site; other site
591946005056	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
591946005057	FAD binding domain; Region: FAD_binding_4; pfam01565
591946005058	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
591946005059	putative inner membrane protein; Provisional; Region: PRK10983
591946005060	Domain of unknown function DUF20; Region: UPF0118; pfam01594
591946005061	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
591946005062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946005063	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591946005064	putative substrate translocation pore; other site
591946005065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946005066	putative substrate translocation pore; other site
591946005067	quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749
591946005068	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
591946005069	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
591946005070	shikimate binding site; other site
591946005071	NAD(P) binding site [chemical binding]; other site
591946005072	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
591946005073	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
591946005074	active site
591946005075	catalytic residue [active]
591946005076	dimer interface [polypeptide binding]; other site
591946005077	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
591946005078	Coenzyme A transferase; Region: CoA_trans; smart00882
591946005079	Coenzyme A transferase; Region: CoA_trans; cl17247
591946005080	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
591946005081	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
591946005082	active site
591946005083	Cupin domain; Region: Cupin_2; pfam07883
591946005084	Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336
591946005085	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591946005086	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946005087	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
591946005088	Ligand binding site [chemical binding]; other site
591946005089	Electron transfer flavoprotein domain; Region: ETF; pfam01012
591946005090	electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916
591946005091	Electron transfer flavoprotein domain; Region: ETF; smart00893
591946005092	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
591946005093	oxidoreductase; Provisional; Region: PRK10015
591946005094	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
591946005095	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
591946005096	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
591946005097	acyl-activating enzyme (AAE) consensus motif; other site
591946005098	putative AMP binding site [chemical binding]; other site
591946005099	putative active site [active]
591946005100	putative CoA binding site [chemical binding]; other site
591946005101	phosphoenolpyruvate synthase; Validated; Region: PRK06464
591946005102	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
591946005103	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591946005104	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
591946005105	PEP synthetase regulatory protein; Provisional; Region: PRK05339
591946005106	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
591946005107	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
591946005108	Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256
591946005109	Uncharacterized conserved protein [Function unknown]; Region: COG0397
591946005110	hypothetical protein; Validated; Region: PRK00029
591946005111	c-di-GMP phosphodiesterase class I (EAL domain) [Signal    transduction mechanisms]; Region: Rtn; COG2200
591946005112	NlpC/P60 family; Region: NLPC_P60; pfam00877
591946005113	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
591946005114	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
591946005115	Walker A/P-loop; other site
591946005116	ATP binding site [chemical binding]; other site
591946005117	Q-loop/lid; other site
591946005118	ABC transporter signature motif; other site
591946005119	Walker B; other site
591946005120	D-loop; other site
591946005121	H-loop/switch region; other site
591946005122	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
591946005123	catalytic residues [active]
591946005124	dimer interface [polypeptide binding]; other site
591946005125	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
591946005126	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591946005127	ABC-ATPase subunit  interface; other site
591946005128	dimer interface [polypeptide binding]; other site
591946005129	putative PBP binding regions; other site
591946005130	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
591946005131	IHF dimer interface [polypeptide binding]; other site
591946005132	IHF - DNA interface [nucleotide binding]; other site
591946005133	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
591946005134	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
591946005135	putative tRNA-binding site [nucleotide binding]; other site
591946005136	B3/4 domain; Region: B3_4; pfam03483
591946005137	tRNA synthetase B5 domain; Region: B5; smart00874
591946005138	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
591946005139	dimer interface [polypeptide binding]; other site
591946005140	motif 1; other site
591946005141	motif 3; other site
591946005142	motif 2; other site
591946005143	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
591946005144	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
591946005145	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
591946005146	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
591946005147	dimer interface [polypeptide binding]; other site
591946005148	motif 1; other site
591946005149	active site
591946005150	motif 2; other site
591946005151	motif 3; other site
591946005152	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
591946005153	23S rRNA binding site [nucleotide binding]; other site
591946005154	L21 binding site [polypeptide binding]; other site
591946005155	L13 binding site [polypeptide binding]; other site
591946005156	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
591946005157	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
591946005158	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
591946005159	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
591946005160	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
591946005161	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
591946005162	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
591946005163	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
591946005164	active site
591946005165	dimer interface [polypeptide binding]; other site
591946005166	motif 1; other site
591946005167	motif 2; other site
591946005168	motif 3; other site
591946005169	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
591946005170	anticodon binding site; other site
591946005171	536; 55989; APEC_01; ATC8739; CFT073; E24377A; ED1a; HS; IAI1; IAI39; E2348, EDL933; EC4115; 157_H7; S88; SE11; SMS_3_5; UMN026; UTI89; K12_DH10B; K12_MG1655; K12_W3110
591946005172	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
591946005173	6-phosphofructokinase 2; Provisional; Region: PRK10294
591946005174	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
591946005175	putative substrate binding site [chemical binding]; other site
591946005176	putative ATP binding site [chemical binding]; other site
591946005177	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
591946005178	Phosphotransferase enzyme family; Region: APH; pfam01636
591946005179	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
591946005180	active site
591946005181	ATP binding site [chemical binding]; other site
591946005182	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
591946005183	YniB-like protein; Region: YniB; pfam14002
591946005184	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
591946005185	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
591946005186	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946005187	motif II; other site
591946005188	inner membrane protein; Provisional; Region: PRK11648
591946005189	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
591946005190	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
591946005191	cell division modulator; Provisional; Region: PRK10113
591946005192	hydroperoxidase II; Provisional; Region: katE; PRK11249
591946005193	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
591946005194	tetramer interface [polypeptide binding]; other site
591946005195	heme binding pocket [chemical binding]; other site
591946005196	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
591946005197	domain interactions; other site
591946005198	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
591946005199	putative active site [active]
591946005200	YdjC motif; other site
591946005201	Mg binding site [ion binding]; other site
591946005202	putative homodimer interface [polypeptide binding]; other site
591946005203	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
591946005204	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
591946005205	NAD binding site [chemical binding]; other site
591946005206	sugar binding site [chemical binding]; other site
591946005207	divalent metal binding site [ion binding]; other site
591946005208	tetramer (dimer of dimers) interface [polypeptide binding]; other site
591946005209	dimer interface [polypeptide binding]; other site
591946005210	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
591946005211	Cupin domain; Region: Cupin_2; pfam07883
591946005212	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946005213	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
591946005214	methionine cluster; other site
591946005215	active site
591946005216	phosphorylation site [posttranslational modification]
591946005217	metal binding site [ion binding]; metal-binding site
591946005218	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
591946005219	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
591946005220	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
591946005221	active site
591946005222	P-loop; other site
591946005223	phosphorylation site [posttranslational modification]
591946005224	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
591946005225	NAD+ synthetase; Region: nadE; TIGR00552
591946005226	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
591946005227	homodimer interface [polypeptide binding]; other site
591946005228	NAD binding pocket [chemical binding]; other site
591946005229	ATP binding pocket [chemical binding]; other site
591946005230	Mg binding site [ion binding]; other site
591946005231	active-site loop [active]
591946005232	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
591946005233	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
591946005234	GIY-YIG motif/motif A; other site
591946005235	active site
591946005236	catalytic site [active]
591946005237	putative DNA binding site [nucleotide binding]; other site
591946005238	metal binding site [ion binding]; metal-binding site
591946005239	hypothetical protein; Provisional; Region: PRK11396
591946005240	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
591946005241	dimer interface [polypeptide binding]; other site
591946005242	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
591946005243	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
591946005244	putative active site [active]
591946005245	Zn binding site [ion binding]; other site
591946005246	succinylarginine dihydrolase; Provisional; Region: PRK13281
591946005247	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
591946005248	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
591946005249	NAD(P) binding site [chemical binding]; other site
591946005250	catalytic residues [active]
591946005251	arginine succinyltransferase; Provisional; Region: PRK10456
591946005252	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
591946005253	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
591946005254	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
591946005255	inhibitor-cofactor binding pocket; inhibition site
591946005256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946005257	catalytic residue [active]
591946005258	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
591946005259	putative catalytic site [active]
591946005260	putative phosphate binding site [ion binding]; other site
591946005261	active site
591946005262	metal binding site A [ion binding]; metal-binding site
591946005263	DNA binding site [nucleotide binding]
591946005264	putative AP binding site [nucleotide binding]; other site
591946005265	putative metal binding site B [ion binding]; other site
591946005266	Uncharacterized conserved protein [Function unknown]; Region: COG0398
591946005267	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
591946005268	Uncharacterized conserved protein [Function unknown]; Region: COG0398
591946005269	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
591946005270	Uncharacterized conserved protein [Function unknown]; Region: COG2128
591946005271	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
591946005272	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
591946005273	hypothetical protein; Provisional; Region: PRK11622
591946005274	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135
591946005275	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946005276	dimer interface [polypeptide binding]; other site
591946005277	conserved gate region; other site
591946005278	putative PBP binding loops; other site
591946005279	ABC-ATPase subunit interface; other site
591946005280	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
591946005281	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946005282	Walker A/P-loop; other site
591946005283	ATP binding site [chemical binding]; other site
591946005284	Q-loop/lid; other site
591946005285	ABC transporter signature motif; other site
591946005286	Walker B; other site
591946005287	D-loop; other site
591946005288	H-loop/switch region; other site
591946005289	Rhodanese Homology Domain; Region: RHOD; smart00450
591946005290	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
591946005291	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
591946005292	active site residue [active]
591946005293	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
591946005294	active site residue [active]
591946005295	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
591946005296	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
591946005297	active site
591946005298	8-oxo-dGMP binding site [chemical binding]; other site
591946005299	nudix motif; other site
591946005300	metal binding site [ion binding]; metal-binding site
591946005301	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
591946005302	glutamate dehydrogenase; Provisional; Region: PRK09414
591946005303	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
591946005304	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
591946005305	NAD(P) binding site [chemical binding]; other site
591946005306	DNA topoisomerase III; Provisional; Region: PRK07726
591946005307	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
591946005308	active site
591946005309	putative interdomain interaction site [polypeptide binding]; other site
591946005310	putative metal-binding site [ion binding]; other site
591946005311	putative nucleotide binding site [chemical binding]; other site
591946005312	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
591946005313	domain I; other site
591946005314	DNA binding groove [nucleotide binding]
591946005315	phosphate binding site [ion binding]; other site
591946005316	domain II; other site
591946005317	domain III; other site
591946005318	nucleotide binding site [chemical binding]; other site
591946005319	catalytic site [active]
591946005320	domain IV; other site
591946005321	selenophosphate synthetase; Provisional; Region: PRK00943
591946005322	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
591946005323	dimerization interface [polypeptide binding]; other site
591946005324	putative ATP binding site [chemical binding]; other site
591946005325	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
591946005326	putative FMN binding site [chemical binding]; other site
591946005327	protease 4; Provisional; Region: PRK10949
591946005328	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
591946005329	tandem repeat interface [polypeptide binding]; other site
591946005330	oligomer interface [polypeptide binding]; other site
591946005331	active site residues [active]
591946005332	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
591946005333	tandem repeat interface [polypeptide binding]; other site
591946005334	oligomer interface [polypeptide binding]; other site
591946005335	active site residues [active]
591946005336	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
591946005337	active site
591946005338	homodimer interface [polypeptide binding]; other site
591946005339	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
591946005340	Isochorismatase family; Region: Isochorismatase; pfam00857
591946005341	catalytic triad [active]
591946005342	metal binding site [ion binding]; metal-binding site
591946005343	conserved cis-peptide bond; other site
591946005344	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
591946005345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946005346	putative substrate translocation pore; other site
591946005347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946005348	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591946005349	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
591946005350	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946005351	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591946005352	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591946005353	active site
591946005354	catalytic tetrad [active]
591946005355	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591946005356	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
591946005357	substrate binding site [chemical binding]; other site
591946005358	ATP binding site [chemical binding]; other site
591946005359	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
591946005360	intersubunit interface [polypeptide binding]; other site
591946005361	active site
591946005362	zinc binding site [ion binding]; other site
591946005363	Na+ binding site [ion binding]; other site
591946005364	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591946005365	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
591946005366	inhibitor binding site; inhibition site
591946005367	catalytic Zn binding site [ion binding]; other site
591946005368	structural Zn binding site [ion binding]; other site
591946005369	NADP binding site [chemical binding]; other site
591946005370	tetramer interface [polypeptide binding]; other site
591946005371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946005372	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946005373	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591946005374	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
591946005375	putative NAD(P) binding site [chemical binding]; other site
591946005376	catalytic Zn binding site [ion binding]; other site
591946005377	structural Zn binding site [ion binding]; other site
591946005378	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
591946005379	methionine sulfoxide reductase B; Provisional; Region: PRK00222
591946005380	SelR domain; Region: SelR; pfam01641
591946005381	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
591946005382	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
591946005383	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
591946005384	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
591946005385	active site
591946005386	phosphate binding residues; other site
591946005387	catalytic residues [active]
591946005388	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591946005389	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591946005390	active site
591946005391	catalytic tetrad [active]
591946005392	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
591946005393	PrkA family serine protein kinase; Provisional; Region: PRK15455
591946005394	AAA ATPase domain; Region: AAA_16; pfam13191
591946005395	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
591946005396	hypothetical protein; Provisional; Region: PRK05325
591946005397	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591946005398	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946005399	metal binding site [ion binding]; metal-binding site
591946005400	active site
591946005401	I-site; other site
591946005402	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591946005403	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946005404	metal binding site [ion binding]; metal-binding site
591946005405	active site
591946005406	I-site; other site
591946005407	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
591946005408	putative deacylase active site [active]
591946005409	Predicted membrane protein [Function unknown]; Region: COG2707
591946005410	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591946005411	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946005412	cyanate transporter; Region: CynX; TIGR00896
591946005413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946005414	Uncharacterized conserved protein [Function unknown]; Region: COG3189
591946005415	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
591946005416	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
591946005417	Domain of unknown function (DUF333); Region: DUF333; pfam03891
591946005418	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
591946005419	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
591946005420	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591946005421	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946005422	metal binding site [ion binding]; metal-binding site
591946005423	active site
591946005424	I-site; other site
591946005425	hypothetical protein; Provisional; Region: PRK10457
591946005426	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
591946005427	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
591946005428	leucine export protein LeuE; Provisional; Region: PRK10958
591946005429	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591946005430	ribonuclease D; Provisional; Region: PRK10829
591946005431	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
591946005432	catalytic site [active]
591946005433	putative active site [active]
591946005434	putative substrate binding site [chemical binding]; other site
591946005435	Helicase and RNase D C-terminal; Region: HRDC; smart00341
591946005436	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
591946005437	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
591946005438	acyl-activating enzyme (AAE) consensus motif; other site
591946005439	putative AMP binding site [chemical binding]; other site
591946005440	putative active site [active]
591946005441	putative CoA binding site [chemical binding]; other site
591946005442	outer membrane lipoprotein, Slp family; Region: slp; TIGR00752
591946005443	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
591946005444	Glycoprotease family; Region: Peptidase_M22; pfam00814
591946005445	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
591946005446	DEAD/DEAH box helicase; Region: DEAD; pfam00270
591946005447	DEAD_2; Region: DEAD_2; pfam06733
591946005448	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
591946005449	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
591946005450	homotrimer interaction site [polypeptide binding]; other site
591946005451	putative active site [active]
591946005452	Domain of unknown function (DUF1889); Region: DUF1889; pfam08986
591946005453	hypothetical protein; Provisional; Region: PRK05114
591946005454	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
591946005455	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
591946005456	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
591946005457	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
591946005458	putative active site [active]
591946005459	putative CoA binding site [chemical binding]; other site
591946005460	nudix motif; other site
591946005461	metal binding site [ion binding]; metal-binding site
591946005462	L-serine deaminase; Provisional; Region: PRK15023
591946005463	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
591946005464	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
591946005465	phage resistance protein; Provisional; Region: PRK10551
591946005466	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
591946005467	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946005468	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
591946005469	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
591946005470	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
591946005471	Transporter associated domain; Region: CorC_HlyC; smart01091
591946005472	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
591946005473	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
591946005474	active pocket/dimerization site; other site
591946005475	active site
591946005476	phosphorylation site [posttranslational modification]
591946005477	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
591946005478	active site
591946005479	phosphorylation site [posttranslational modification]
591946005480	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
591946005481	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
591946005482	Predicted membrane protein [Function unknown]; Region: COG4811
591946005483	hypothetical protein; Provisional; Region: PRK11469
591946005484	Domain of unknown function DUF; Region: DUF204; pfam02659
591946005485	Domain of unknown function DUF; Region: DUF204; pfam02659
591946005486	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
591946005487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946005488	S-adenosylmethionine binding site [chemical binding]; other site
591946005489	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591946005490	DNA-binding site [nucleotide binding]; DNA binding site
591946005491	RNA-binding motif; other site
591946005492	Protein of unknown function (DUF2627); Region: DUF2527; pfam10736
591946005493	YebO-like protein; Region: YebO; pfam13974
591946005494	PhoPQ regulatory protein; Provisional; Region: PRK10299
591946005495	YobH-like protein; Region: YobH; pfam13996
591946005496	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
591946005497	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591946005498	dimerization interface [polypeptide binding]; other site
591946005499	putative Zn2+ binding site [ion binding]; other site
591946005500	putative DNA binding site [nucleotide binding]; other site
591946005501	Bacterial transcriptional regulator; Region: IclR; pfam01614
591946005502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946005503	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591946005504	putative substrate translocation pore; other site
591946005505	Predicted integral membrane protein [Function unknown]; Region: COG5521
591946005506	Transposase IS200 like; Region: Y1_Tnp; pfam01797
591946005507	heat shock protein HtpX; Provisional; Region: PRK05457
591946005508	carboxy-terminal protease; Provisional; Region: PRK11186
591946005509	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
591946005510	protein binding site [polypeptide binding]; other site
591946005511	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
591946005512	Catalytic dyad [active]
591946005513	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
591946005514	ProP expression regulator; Provisional; Region: PRK04950
591946005515	ProQ/FINO family; Region: ProQ; pfam04352
591946005516	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
591946005517	GAF domain; Region: GAF_2; pfam13185
591946005518	integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155
591946005519	Paraquat-inducible protein A; Region: PqiA; pfam04403
591946005520	Paraquat-inducible protein A; Region: PqiA; pfam04403
591946005521	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
591946005522	mce related protein; Region: MCE; pfam02470
591946005523	mce related protein; Region: MCE; pfam02470
591946005524	mce related protein; Region: MCE; pfam02470
591946005525	mce related protein; Region: MCE; pfam02470
591946005526	mce related protein; Region: MCE; pfam02470
591946005527	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
591946005528	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946005529	S-adenosylmethionine binding site [chemical binding]; other site
591946005530	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
591946005531	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
591946005532	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
591946005533	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
591946005534	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
591946005535	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
591946005536	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
591946005537	hypothetical protein; Provisional; Region: PRK10301
591946005538	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
591946005539	Predicted amidohydrolase [General function prediction only]; Region: COG0388
591946005540	Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795
591946005541	exodeoxyribonuclease X; Provisional; Region: PRK07983
591946005542	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
591946005543	active site
591946005544	catalytic site [active]
591946005545	substrate binding site [chemical binding]; other site
591946005546	protease 2; Provisional; Region: PRK10115
591946005547	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
591946005548	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
591946005549	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
591946005550	putative metal binding site [ion binding]; other site
591946005551	hypothetical protein; Provisional; Region: PRK13680
591946005552	DNA damage-inducible protein YebG; Provisional; Region: PRK10061
591946005553	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
591946005554	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591946005555	ATP-grasp domain; Region: ATP-grasp; pfam02222
591946005556	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
591946005557	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
591946005558	active site
591946005559	intersubunit interface [polypeptide binding]; other site
591946005560	catalytic residue [active]
591946005561	phosphogluconate dehydratase; Validated; Region: PRK09054
591946005562	6-phosphogluconate dehydratase; Region: edd; TIGR01196
591946005563	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
591946005564	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
591946005565	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
591946005566	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
591946005567	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
591946005568	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
591946005569	putative active site [active]
591946005570	pyruvate kinase; Provisional; Region: PRK05826
591946005571	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
591946005572	domain interfaces; other site
591946005573	active site
591946005574	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
591946005575	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
591946005576	putative acyl-acceptor binding pocket; other site
591946005577	putative peptidase; Provisional; Region: PRK11649
591946005578	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
591946005579	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591946005580	Peptidase family M23; Region: Peptidase_M23; pfam01551
591946005581	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
591946005582	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
591946005583	metal binding site [ion binding]; metal-binding site
591946005584	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
591946005585	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
591946005586	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
591946005587	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591946005588	ABC-ATPase subunit  interface; other site
591946005589	dimer interface [polypeptide binding]; other site
591946005590	putative PBP binding regions; other site
591946005591	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
591946005592	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946005593	Walker A motif; other site
591946005594	ATP binding site [chemical binding]; other site
591946005595	Walker B motif; other site
591946005596	arginine finger; other site
591946005597	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
591946005598	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
591946005599	RuvA N terminal domain; Region: RuvA_N; pfam01330
591946005600	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
591946005601	hypothetical protein; Provisional; Region: PRK11470
591946005602	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
591946005603	active site
591946005604	putative DNA-binding cleft [nucleotide binding]; other site
591946005605	dimer interface [polypeptide binding]; other site
591946005606	hypothetical protein; Validated; Region: PRK00110
591946005607	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
591946005608	nudix motif; other site
591946005609	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
591946005610	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
591946005611	dimer interface [polypeptide binding]; other site
591946005612	anticodon binding site; other site
591946005613	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
591946005614	homodimer interface [polypeptide binding]; other site
591946005615	motif 1; other site
591946005616	active site
591946005617	motif 2; other site
591946005618	GAD domain; Region: GAD; pfam02938
591946005619	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
591946005620	motif 3; other site
591946005621	Isochorismatase family; Region: Isochorismatase; pfam00857
591946005622	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
591946005623	catalytic triad [active]
591946005624	conserved cis-peptide bond; other site
591946005625	hypothetical protein; Provisional; Region: PRK10302
591946005626	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
591946005627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946005628	S-adenosylmethionine binding site [chemical binding]; other site
591946005629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946005630	S-adenosylmethionine binding site [chemical binding]; other site
591946005631	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
591946005632	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
591946005633	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
591946005634	molybdopterin cofactor binding site [chemical binding]; other site
591946005635	substrate binding site [chemical binding]; other site
591946005636	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
591946005637	molybdopterin cofactor binding site; other site
591946005638	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
591946005639	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
591946005640	copper homeostasis protein CutC; Provisional; Region: PRK11572
591946005641	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
591946005642	putative metal binding site [ion binding]; other site
591946005643	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
591946005644	arginyl-tRNA synthetase; Region: argS; TIGR00456
591946005645	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
591946005646	active site
591946005647	HIGH motif; other site
591946005648	KMSK motif region; other site
591946005649	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
591946005650	tRNA binding surface [nucleotide binding]; other site
591946005651	anticodon binding site; other site
591946005652	Flagellar protein FlhE; Region: FlhE; pfam06366
591946005653	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
591946005654	FHIPEP family; Region: FHIPEP; pfam00771
591946005655	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
591946005656	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
591946005657	chemotaxis regulator CheZ; Provisional; Region: PRK11166
591946005658	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
591946005659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946005660	active site
591946005661	phosphorylation site [posttranslational modification]
591946005662	intermolecular recognition site; other site
591946005663	dimerization interface [polypeptide binding]; other site
591946005664	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
591946005665	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946005666	active site
591946005667	phosphorylation site [posttranslational modification]
591946005668	intermolecular recognition site; other site
591946005669	dimerization interface [polypeptide binding]; other site
591946005670	CheB methylesterase; Region: CheB_methylest; pfam01339
591946005671	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
591946005672	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
591946005673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946005674	S-adenosylmethionine binding site [chemical binding]; other site
591946005675	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
591946005676	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
591946005677	dimer interface [polypeptide binding]; other site
591946005678	ligand binding site [chemical binding]; other site
591946005679	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591946005680	dimerization interface [polypeptide binding]; other site
591946005681	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
591946005682	dimer interface [polypeptide binding]; other site
591946005683	putative CheW interface [polypeptide binding]; other site
591946005684	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
591946005685	putative CheA interaction surface; other site
591946005686	chemotaxis protein CheA; Provisional; Region: PRK10547
591946005687	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
591946005688	putative binding surface; other site
591946005689	active site
591946005690	CheY binding; Region: CheY-binding; pfam09078
591946005691	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
591946005692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946005693	ATP binding site [chemical binding]; other site
591946005694	Mg2+ binding site [ion binding]; other site
591946005695	G-X-G motif; other site
591946005696	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
591946005697	flagellar motor protein MotB; Validated; Region: motB; PRK09041
591946005698	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
591946005699	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
591946005700	ligand binding site [chemical binding]; other site
591946005701	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
591946005702	flagellar motor protein MotA; Validated; Region: PRK09110
591946005703	transcriptional activator FlhC; Provisional; Region: PRK12722
591946005704	transcriptional activator FlhD; Provisional; Region: PRK02909
591946005705	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591946005706	Ligand Binding Site [chemical binding]; other site
591946005707	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
591946005708	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
591946005709	active site
591946005710	homotetramer interface [polypeptide binding]; other site
591946005711	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187
591946005712	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
591946005713	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591946005714	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591946005715	TM-ABC transporter signature motif; other site
591946005716	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
591946005717	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591946005718	Walker A/P-loop; other site
591946005719	ATP binding site [chemical binding]; other site
591946005720	Q-loop/lid; other site
591946005721	ABC transporter signature motif; other site
591946005722	Walker B; other site
591946005723	D-loop; other site
591946005724	H-loop/switch region; other site
591946005725	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591946005726	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
591946005727	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
591946005728	ligand binding site [chemical binding]; other site
591946005729	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
591946005730	Ferritin-like domain; Region: Ferritin; pfam00210
591946005731	ferroxidase diiron center [ion binding]; other site
591946005732	Protein of unknown function (DUF2766); Region: DUF2766; pfam10964
591946005733	YecR-like lipoprotein; Region: YecR; pfam13992
591946005734	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
591946005735	Ferritin-like domain; Region: Ferritin; pfam00210
591946005736	ferroxidase diiron center [ion binding]; other site
591946005737	probable metal-binding protein; Region: matur_matur; TIGR03853
591946005738	tyrosine transporter TyrP; Provisional; Region: PRK15132
591946005739	aromatic amino acid transport protein; Region: araaP; TIGR00837
591946005740	hypothetical protein; Provisional; Region: PRK10396
591946005741	yecA family protein; Region: ygfB_yecA; TIGR02292
591946005742	SEC-C motif; Region: SEC-C; pfam02810
591946005743	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
591946005744	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
591946005745	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
591946005746	GIY-YIG motif/motif A; other site
591946005747	active site
591946005748	catalytic site [active]
591946005749	putative DNA binding site [nucleotide binding]; other site
591946005750	metal binding site [ion binding]; metal-binding site
591946005751	UvrB/uvrC motif; Region: UVR; pfam02151
591946005752	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
591946005753	Helix-hairpin-helix motif; Region: HHH; pfam00633
591946005754	response regulator; Provisional; Region: PRK09483
591946005755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946005756	active site
591946005757	phosphorylation site [posttranslational modification]
591946005758	intermolecular recognition site; other site
591946005759	dimerization interface [polypeptide binding]; other site
591946005760	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946005761	DNA binding residues [nucleotide binding]
591946005762	dimerization interface [polypeptide binding]; other site
591946005763	hypothetical protein; Provisional; Region: PRK10613
591946005764	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
591946005765	Autoinducer binding domain; Region: Autoind_bind; pfam03472
591946005766	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946005767	DNA binding residues [nucleotide binding]
591946005768	dimerization interface [polypeptide binding]; other site
591946005769	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
591946005770	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
591946005771	Walker A/P-loop; other site
591946005772	ATP binding site [chemical binding]; other site
591946005773	Q-loop/lid; other site
591946005774	ABC transporter signature motif; other site
591946005775	Walker B; other site
591946005776	D-loop; other site
591946005777	H-loop/switch region; other site
591946005778	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591946005779	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946005780	dimer interface [polypeptide binding]; other site
591946005781	conserved gate region; other site
591946005782	putative PBP binding loops; other site
591946005783	ABC-ATPase subunit interface; other site
591946005784	D-cysteine desulfhydrase; Validated; Region: PRK03910
591946005785	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
591946005786	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946005787	catalytic residue [active]
591946005788	cystine transporter subunit; Provisional; Region: PRK11260
591946005789	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946005790	substrate binding pocket [chemical binding]; other site
591946005791	membrane-bound complex binding site; other site
591946005792	hinge residues; other site
591946005793	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
591946005794	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
591946005795	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
591946005796	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
591946005797	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
591946005798	DNA binding residues [nucleotide binding]
591946005799	flagellin; Validated; Region: PRK08026
591946005800	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
591946005801	Flagellin protein; Region: FliC; pfam12445
591946005802	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
591946005803	flagellar capping protein; Reviewed; Region: fliD; PRK08032
591946005804	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
591946005805	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
591946005806	Flagellar protein FliS; Region: FliS; cl00654
591946005807	flagellar biosynthesis protein FliT; Provisional; Region: PRK10548
591946005808	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
591946005809	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
591946005810	active site
591946005811	Na/Ca binding site [ion binding]; other site
591946005812	catalytic site [active]
591946005813	lipoprotein; Provisional; Region: PRK10397
591946005814	putative inner membrane protein; Provisional; Region: PRK11099
591946005815	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
591946005816	CPxP  motif; other site
591946005818	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591946005819	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591946005820	trimer interface [polypeptide binding]; other site
591946005821	eyelet of channel; other site
591946005822	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591946005823	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
591946005824	substrate binding site [chemical binding]; other site
591946005825	multidrug efflux protein; Reviewed; Region: emrE; PRK09541
591946005826	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
591946005827	flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206
591946005828	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
591946005829	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
591946005830	flagellar motor switch protein FliG; Region: fliG; TIGR00207
591946005831	FliG C-terminal domain; Region: FliG_C; pfam01706
591946005832	flagellar assembly protein H; Validated; Region: fliH; PRK05687
591946005833	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
591946005834	Flagellar assembly protein FliH; Region: FliH; pfam02108
591946005835	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
591946005836	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
591946005837	Walker A motif/ATP binding site; other site
591946005838	Walker B motif; other site
591946005839	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
591946005840	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
591946005841	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
591946005842	flagellar hook-length control protein; Provisional; Region: PRK10118
591946005843	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
591946005844	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
591946005845	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
591946005846	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
591946005847	flagellar motor switch protein; Validated; Region: fliN; PRK05698
591946005848	flagellar biosynthesis protein FliO; Provisional; Region: PRK11486
591946005849	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
591946005850	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
591946005851	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
591946005852	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
591946005853	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946005854	DNA binding residues [nucleotide binding]
591946005855	dimerization interface [polypeptide binding]; other site
591946005856	hypothetical protein; Provisional; Region: PRK10708
591946005857	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
591946005858	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
591946005859	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946005860	active site
591946005861	motif I; other site
591946005862	motif II; other site
591946005863	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
591946005864	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946005865	metal binding site [ion binding]; metal-binding site
591946005866	active site
591946005867	I-site; other site
591946005868	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
591946005869	hypothetical protein; Provisional; Region: PRK10062
591946005870	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
591946005871	EamA-like transporter family; Region: EamA; pfam00892
591946005872	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
591946005873	additional DNA contacts [nucleotide binding]; other site
591946005874	mismatch recognition site; other site
591946005875	active site
591946005876	zinc binding site [ion binding]; other site
591946005877	DNA intercalation site [nucleotide binding]; other site
591946005878	DNA cytosine methylase; Provisional; Region: PRK10458
591946005879	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
591946005880	cofactor binding site; other site
591946005881	DNA binding site [nucleotide binding]
591946005882	substrate interaction site [chemical binding]; other site
591946005883	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
591946005884	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591946005885	Zn2+ binding site [ion binding]; other site
591946005886	Mg2+ binding site [ion binding]; other site
591946005887	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
591946005888	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591946005889	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591946005890	trimer interface [polypeptide binding]; other site
591946005891	eyelet of channel; other site
591946005892	chaperone protein HchA; Provisional; Region: PRK04155
591946005893	Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148
591946005894	dimer interface [polypeptide binding]; other site
591946005895	metal binding site [ion binding]; metal-binding site
591946005896	potential oxyanion hole; other site
591946005897	potential catalytic triad [active]
591946005898	conserved cys residue [active]
591946005899	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
591946005900	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946005901	dimer interface [polypeptide binding]; other site
591946005902	phosphorylation site [posttranslational modification]
591946005903	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946005904	ATP binding site [chemical binding]; other site
591946005905	Mg2+ binding site [ion binding]; other site
591946005906	G-X-G motif; other site
591946005907	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
591946005908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946005909	active site
591946005910	phosphorylation site [posttranslational modification]
591946005911	intermolecular recognition site; other site
591946005912	dimerization interface [polypeptide binding]; other site
591946005913	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946005914	DNA binding site [nucleotide binding]
591946005915	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
591946005916	active site
591946005917	homotetramer interface [polypeptide binding]; other site
591946005918	TMAO/DMSO reductase; Reviewed; Region: PRK05363
591946005919	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
591946005920	Moco binding site; other site
591946005921	metal coordination site [ion binding]; other site
591946005922	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
591946005923	zinc/cadmium-binding protein; Provisional; Region: PRK10306
591946005924	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
591946005925	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
591946005926	active site
591946005927	Int/Topo IB signature motif; other site
591946005928	salicylate synthase Irp9; Reviewed; Region: PRK06772
591946005929	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
591946005930	muropeptide transporter; Validated; Region: ampG; cl17669
591946005931	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591946005932	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946005933	Walker A/P-loop; other site
591946005934	ATP binding site [chemical binding]; other site
591946005935	Q-loop/lid; other site
591946005936	ABC transporter signature motif; other site
591946005937	Walker B; other site
591946005938	D-loop; other site
591946005939	H-loop/switch region; other site
591946005940	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591946005941	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
591946005942	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946005943	Walker A/P-loop; other site
591946005944	ATP binding site [chemical binding]; other site
591946005945	Q-loop/lid; other site
591946005946	ABC transporter signature motif; other site
591946005947	Walker B; other site
591946005948	D-loop; other site
591946005949	H-loop/switch region; other site
591946005950	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591946005951	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946005952	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
591946005953	Condensation domain; Region: Condensation; pfam00668
591946005954	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
591946005955	Nonribosomal peptide synthase; Region: NRPS; pfam08415
591946005956	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
591946005957	acyl-activating enzyme (AAE) consensus motif; other site
591946005958	AMP binding site [chemical binding]; other site
591946005959	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946005960	S-adenosylmethionine binding site [chemical binding]; other site
591946005961	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
591946005962	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
591946005963	Condensation domain; Region: Condensation; pfam00668
591946005964	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
591946005965	Nonribosomal peptide synthase; Region: NRPS; pfam08415
591946005966	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
591946005967	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
591946005968	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
591946005969	active site
591946005970	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
591946005971	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
591946005972	Methyltransferase domain; Region: Methyltransf_31; pfam13847
591946005973	Methyltransferase domain; Region: Methyltransf_12; pfam08242
591946005974	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
591946005975	KR domain; Region: KR; pfam08659
591946005976	NADP binding site [chemical binding]; other site
591946005977	active site
591946005978	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
591946005979	Condensation domain; Region: Condensation; pfam00668
591946005980	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
591946005981	Nonribosomal peptide synthase; Region: NRPS; pfam08415
591946005982	Methyltransferase domain; Region: Methyltransf_12; pfam08242
591946005983	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
591946005984	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
591946005985	Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693
591946005986	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
591946005987	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
591946005988	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
591946005989	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
591946005990	acyl-activating enzyme (AAE) consensus motif; other site
591946005991	active site
591946005992	AMP binding site [chemical binding]; other site
591946005993	substrate binding site [chemical binding]; other site
591946005994	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
591946005995	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591946005996	N-terminal plug; other site
591946005997	ligand-binding site [chemical binding]; other site
591946005998	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
591946005999	potential frameshift: common BLAST hit: gi|117624169|ref|YP_853082.1| autotransporter
591946006000	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
591946006001	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
591946006002	Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369
591946006003	Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369
591946006004	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
591946006005	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
591946006006	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
591946006007	shikimate transporter; Provisional; Region: PRK09952
591946006008	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946006009	putative substrate translocation pore; other site
591946006010	AMP nucleosidase; Provisional; Region: PRK08292
591946006011	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
591946006012	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
591946006013	hypothetical protein; Provisional; Region: PRK12378
591946006014	MATE family multidrug exporter; Provisional; Region: PRK10189
591946006015	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
591946006016	transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679
591946006017	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946006018	The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444
591946006019	putative substrate binding site [chemical binding]; other site
591946006020	dimerization interface [polypeptide binding]; other site
591946006021	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
591946006022	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946006023	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
591946006024	putative dimerization interface [polypeptide binding]; other site
591946006025	corresponding to LF82_p309 in publication : Miquel et al., PLoS One; 536; 55989; APEC_01; ATC8739; CFT073; ED1a; IAI39; S88; UMN026; UTI89
591946006026	Transposase IS200 like; Region: Y1_Tnp; pfam01797
591946006027	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
591946006028	Integrase; Region: Integrase_1; pfam12835
591946006029	PemK-like protein; Region: PemK; cl00995
591946006030	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
591946006031	Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423
591946006032	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
591946006033	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591946006034	Transposase [DNA replication, recombination, and repair]; Region: COG5433
591946006035	Transposase [DNA replication, recombination, and repair]; Region: COG5433
591946006036	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
591946006037	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946006038	Walker A/P-loop; other site
591946006039	ATP binding site [chemical binding]; other site
591946006040	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
591946006041	putative active site [active]
591946006042	putative metal-binding site [ion binding]; other site
591946006043	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
591946006044	Part of AAA domain; Region: AAA_19; pfam13245
591946006045	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
591946006046	tetramer interface [polypeptide binding]; other site
591946006047	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
591946006048	active site
591946006049	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
591946006050	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591946006051	NAD(P) binding site [chemical binding]; other site
591946006052	active site
591946006053	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
591946006054	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
591946006055	substrate binding site [chemical binding]; other site
591946006056	hexamer interface [polypeptide binding]; other site
591946006057	metal binding site [ion binding]; metal-binding site
591946006058	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
591946006059	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
591946006060	active site
591946006061	P-loop; other site
591946006062	phosphorylation site [posttranslational modification]
591946006063	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591946006064	active site
591946006065	phosphorylation site [posttranslational modification]
591946006066	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591946006067	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
591946006068	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946006069	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
591946006070	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
591946006071	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
591946006072	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
591946006073	active site
591946006074	P-loop; other site
591946006075	phosphorylation site [posttranslational modification]
591946006076	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591946006077	active site
591946006078	phosphorylation site [posttranslational modification]
591946006079	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
591946006080	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
591946006081	L,D-transpeptidase; Provisional; Region: PRK10190
591946006082	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591946006083	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
591946006084	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
591946006085	putative dimer interface [polypeptide binding]; other site
591946006086	active site pocket [active]
591946006087	putative cataytic base [active]
591946006088	cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317
591946006089	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
591946006090	homotrimer interface [polypeptide binding]; other site
591946006091	Walker A motif; other site
591946006092	GTP binding site [chemical binding]; other site
591946006093	Walker B motif; other site
591946006094	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
591946006095	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
591946006096	Sensory domain found in PocR; Region: PocR; pfam10114
591946006097	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
591946006098	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946006099	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946006100	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
591946006101	amphipathic channel; other site
591946006102	Asn-Pro-Ala signature motifs; other site
591946006103	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
591946006104	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
591946006105	Hexamer interface [polypeptide binding]; other site
591946006106	Putative hexagonal pore residue; other site
591946006107	propanediol utilization protein PduB; Provisional; Region: PRK15415
591946006108	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
591946006109	putative hexamer interface [polypeptide binding]; other site
591946006110	putative hexagonal pore; other site
591946006111	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
591946006112	putative hexamer interface [polypeptide binding]; other site
591946006113	putative hexagonal pore; other site
591946006114	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
591946006115	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
591946006116	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
591946006117	alpha-beta subunit interface [polypeptide binding]; other site
591946006118	alpha-gamma subunit interface [polypeptide binding]; other site
591946006119	active site
591946006120	substrate and K+ binding site; other site
591946006121	K+ binding site [ion binding]; other site
591946006122	cobalamin binding site [chemical binding]; other site
591946006123	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
591946006124	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
591946006125	Cell division protein FtsA; Region: FtsA; cl17206
591946006126	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
591946006127	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
591946006128	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
591946006129	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
591946006130	Hexamer interface [polypeptide binding]; other site
591946006131	Putative hexagonal pore residue; other site
591946006132	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
591946006133	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
591946006134	putative hexamer interface [polypeptide binding]; other site
591946006135	putative hexagonal pore; other site
591946006136	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
591946006137	Propanediol utilisation protein PduL; Region: PduL; pfam06130
591946006138	Propanediol utilisation protein PduL; Region: PduL; pfam06130
591946006139	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
591946006140	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
591946006141	Hexamer/Pentamer interface [polypeptide binding]; other site
591946006142	central pore; other site
591946006143	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
591946006144	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
591946006145	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
591946006146	putative catalytic cysteine [active]
591946006147	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
591946006148	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
591946006149	putative active site [active]
591946006150	metal binding site [ion binding]; metal-binding site
591946006151	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
591946006152	SLBB domain; Region: SLBB; pfam10531
591946006153	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
591946006154	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
591946006155	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
591946006156	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
591946006157	putative hexamer interface [polypeptide binding]; other site
591946006158	putative hexagonal pore; other site
591946006159	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
591946006160	putative hexamer interface [polypeptide binding]; other site
591946006161	putative hexagonal pore; other site
591946006162	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
591946006163	putative hexamer interface [polypeptide binding]; other site
591946006164	putative hexagonal pore; other site
591946006165	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
591946006166	G1 box; other site
591946006167	GTP/Mg2+ binding site [chemical binding]; other site
591946006168	G2 box; other site
591946006169	G3 box; other site
591946006170	Switch II region; other site
591946006171	G4 box; other site
591946006172	G5 box; other site
591946006173	hypothetical protein; Provisional; Region: PRK05423
591946006174	Predicted membrane protein [Function unknown]; Region: COG1289
591946006175	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
591946006176	DNA gyrase inhibitor; Provisional; Region: PRK10016
591946006177	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
591946006178	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
591946006179	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
591946006180	exonuclease I; Provisional; Region: sbcB; PRK11779
591946006181	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
591946006182	active site
591946006183	catalytic site [active]
591946006184	substrate binding site [chemical binding]; other site
591946006185	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
591946006186	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
591946006187	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946006188	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
591946006189	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591946006190	dimerization interface [polypeptide binding]; other site
591946006191	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
591946006192	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
591946006193	putative NAD(P) binding site [chemical binding]; other site
591946006194	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
591946006195	antitoxin YefM; Provisional; Region: PRK11409
591946006196	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
591946006197	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
591946006198	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
591946006199	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
591946006200	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
591946006201	NAD binding site [chemical binding]; other site
591946006202	dimerization interface [polypeptide binding]; other site
591946006203	product binding site; other site
591946006204	substrate binding site [chemical binding]; other site
591946006205	zinc binding site [ion binding]; other site
591946006206	catalytic residues [active]
591946006207	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
591946006208	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591946006209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946006210	homodimer interface [polypeptide binding]; other site
591946006211	catalytic residue [active]
591946006212	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
591946006213	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946006214	active site
591946006215	motif I; other site
591946006216	motif II; other site
591946006217	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
591946006218	putative active site pocket [active]
591946006219	4-fold oligomerization interface [polypeptide binding]; other site
591946006220	metal binding residues [ion binding]; metal-binding site
591946006221	3-fold/trimer interface [polypeptide binding]; other site
591946006222	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
591946006223	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
591946006224	putative active site [active]
591946006225	oxyanion strand; other site
591946006226	catalytic triad [active]
591946006227	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
591946006228	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
591946006229	catalytic residues [active]
591946006230	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
591946006231	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
591946006232	substrate binding site [chemical binding]; other site
591946006233	glutamase interaction surface [polypeptide binding]; other site
591946006234	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
591946006235	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
591946006236	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
591946006237	metal binding site [ion binding]; metal-binding site
591946006238	chain length determinant protein WzzB; Provisional; Region: PRK15471
591946006239	Chain length determinant protein; Region: Wzz; pfam02706
591946006240	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
591946006241	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
591946006242	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
591946006243	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
591946006244	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
591946006245	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
591946006246	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
591946006247	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
591946006248	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
591946006249	active site
591946006250	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
591946006251	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
591946006252	active site
591946006253	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
591946006254	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
591946006255	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
591946006256	active site
591946006257	tetramer interface; other site
591946006258	putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123
591946006259	colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005
591946006260	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
591946006261	putative ADP-binding pocket [chemical binding]; other site
591946006262	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
591946006263	colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006
591946006264	colanic acid exporter; Provisional; Region: PRK10459
591946006265	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
591946006266	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
591946006267	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
591946006268	phosphomannomutase CpsG; Provisional; Region: PRK15414
591946006269	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
591946006270	active site
591946006271	substrate binding site [chemical binding]; other site
591946006272	metal binding site [ion binding]; metal-binding site
591946006273	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
591946006274	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
591946006275	Substrate binding site; other site
591946006276	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
591946006277	colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007
591946006278	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
591946006279	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
591946006280	active site
591946006281	GDP-Mannose binding site [chemical binding]; other site
591946006282	dimer interface [polypeptide binding]; other site
591946006283	modified nudix motif
591946006284	metal binding site [ion binding]; metal-binding site
591946006285	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
591946006286	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
591946006287	NADP binding site [chemical binding]; other site
591946006288	active site
591946006289	putative substrate binding site [chemical binding]; other site
591946006290	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
591946006291	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
591946006292	NADP-binding site; other site
591946006293	homotetramer interface [polypeptide binding]; other site
591946006294	substrate binding site [chemical binding]; other site
591946006295	homodimer interface [polypeptide binding]; other site
591946006296	active site
591946006297	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
591946006298	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
591946006299	putative trimer interface [polypeptide binding]; other site
591946006300	putative active site [active]
591946006301	putative substrate binding site [chemical binding]; other site
591946006302	putative CoA binding site [chemical binding]; other site
591946006303	putative glycosyl transferase; Provisional; Region: PRK10063
591946006304	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
591946006305	metal-binding site
591946006306	putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010
591946006307	colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015
591946006308	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
591946006309	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
591946006310	putative acyl transferase; Provisional; Region: PRK10191
591946006311	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
591946006312	trimer interface [polypeptide binding]; other site
591946006313	active site
591946006314	substrate binding site [chemical binding]; other site
591946006315	CoA binding site [chemical binding]; other site
591946006316	putative glycosyl transferase; Provisional; Region: PRK10018
591946006317	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
591946006318	active site
591946006319	tyrosine kinase; Provisional; Region: PRK11519
591946006320	Chain length determinant protein; Region: Wzz; pfam02706
591946006321	Chain length determinant protein; Region: Wzz; cl15801
591946006322	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
591946006323	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
591946006324	Low molecular weight phosphatase family; Region: LMWPc; cd00115
591946006325	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
591946006326	active site
591946006327	polysaccharide export protein Wza; Provisional; Region: PRK15078
591946006328	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
591946006329	SLBB domain; Region: SLBB; pfam10531
591946006330	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
591946006331	FOG: CBS domain [General function prediction only]; Region: COG0517
591946006332	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
591946006333	Transporter associated domain; Region: CorC_HlyC; smart01091
591946006334	putative assembly protein; Provisional; Region: PRK10833
591946006335	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
591946006336	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
591946006337	trimer interface [polypeptide binding]; other site
591946006338	active site
591946006339	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
591946006340	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
591946006341	ATP-binding site [chemical binding]; other site
591946006342	Sugar specificity; other site
591946006343	Pyrimidine base specificity; other site
591946006344	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
591946006345	putative diguanylate cyclase; Provisional; Region: PRK09776
591946006346	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591946006347	putative active site [active]
591946006348	heme pocket [chemical binding]; other site
591946006349	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591946006350	putative active site [active]
591946006351	heme pocket [chemical binding]; other site
591946006352	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591946006353	putative active site [active]
591946006354	heme pocket [chemical binding]; other site
591946006355	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946006356	metal binding site [ion binding]; metal-binding site
591946006357	active site
591946006358	I-site; other site
591946006359	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946006360	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
591946006361	AlkA N-terminal domain; Region: AlkA_N; smart01009
591946006362	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
591946006363	minor groove reading motif; other site
591946006364	helix-hairpin-helix signature motif; other site
591946006365	substrate binding pocket [chemical binding]; other site
591946006366	active site
591946006367	putative chaperone; Provisional; Region: PRK11678
591946006368	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
591946006369	nucleotide binding site [chemical binding]; other site
591946006370	putative NEF/HSP70 interaction site [polypeptide binding]; other site
591946006371	SBD interface [polypeptide binding]; other site
591946006372	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
591946006373	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
591946006374	substrate binding site [chemical binding]; other site
591946006375	activation loop (A-loop); other site
591946006376	Y-family of DNA polymerases; Region: PolY; cl12025
591946006377	Protein phosphatase 2C; Region: PP2C_2; pfam13672
591946006378	VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464
591946006379	metal ion-dependent adhesion site (MIDAS); other site
591946006380	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
591946006381	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946006382	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946006383	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
591946006384	Protein export membrane protein; Region: SecD_SecF; cl14618
591946006385	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
591946006386	putative transporter; Provisional; Region: PRK10504
591946006387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946006388	putative substrate translocation pore; other site
591946006389	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
591946006390	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591946006391	dimerization interface [polypeptide binding]; other site
591946006392	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946006393	dimer interface [polypeptide binding]; other site
591946006394	phosphorylation site [posttranslational modification]
591946006395	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946006396	ATP binding site [chemical binding]; other site
591946006397	Mg2+ binding site [ion binding]; other site
591946006398	G-X-G motif; other site
591946006399	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
591946006400	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946006401	active site
591946006402	phosphorylation site [posttranslational modification]
591946006403	intermolecular recognition site; other site
591946006404	dimerization interface [polypeptide binding]; other site
591946006405	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946006406	DNA binding site [nucleotide binding]
591946006407	Uncharacterized conserved protein [Function unknown]; Region: COG3422
591946006408	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
591946006409	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
591946006410	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
591946006411	PcfJ-like protein; Region: PcfJ; pfam14284
591946006412	putative protease; Provisional; Region: PRK15452
591946006413	Peptidase family U32; Region: Peptidase_U32; pfam01136
591946006414	lipid kinase; Reviewed; Region: PRK13054
591946006415	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
591946006416	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591946006417	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
591946006418	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946006419	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
591946006420	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
591946006421	putative NAD(P) binding site [chemical binding]; other site
591946006422	catalytic Zn binding site [ion binding]; other site
591946006423	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
591946006424	PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827
591946006425	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
591946006426	active site
591946006427	P-loop; other site
591946006428	phosphorylation site [posttranslational modification]
591946006429	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591946006430	active site
591946006431	phosphorylation site [posttranslational modification]
591946006432	D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052
591946006433	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
591946006434	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
591946006435	intersubunit interface [polypeptide binding]; other site
591946006436	active site
591946006437	zinc binding site [ion binding]; other site
591946006438	Na+ binding site [ion binding]; other site
591946006439	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
591946006440	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
591946006441	putative active site; other site
591946006442	catalytic residue [active]
591946006443	nucleoside transporter; Region: 2A0110; TIGR00889
591946006444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946006445	putative substrate translocation pore; other site
591946006446	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
591946006447	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591946006448	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
591946006449	substrate binding site [chemical binding]; other site
591946006450	ATP binding site [chemical binding]; other site
591946006451	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
591946006452	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946006453	DNA-binding site [nucleotide binding]; DNA binding site
591946006454	UTRA domain; Region: UTRA; pfam07702
591946006455	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
591946006456	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
591946006457	active site
591946006458	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
591946006459	dimer interface [polypeptide binding]; other site
591946006460	substrate binding site [chemical binding]; other site
591946006461	ATP binding site [chemical binding]; other site
591946006462	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
591946006463	substrate binding site [chemical binding]; other site
591946006464	multimerization interface [polypeptide binding]; other site
591946006465	ATP binding site [chemical binding]; other site
591946006466	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
591946006467	putative metal binding site [ion binding]; other site
591946006468	putative homodimer interface [polypeptide binding]; other site
591946006469	putative homotetramer interface [polypeptide binding]; other site
591946006470	putative homodimer-homodimer interface [polypeptide binding]; other site
591946006471	putative allosteric switch controlling residues; other site
591946006472	nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019
591946006473	Predicted integral membrane protein [Function unknown]; Region: COG5455
591946006474	putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252
591946006475	putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216
591946006476	fimbrial outer membrane usher protein; Provisional; Region: PRK15217
591946006477	PapC N-terminal domain; Region: PapC_N; pfam13954
591946006478	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591946006479	PapC C-terminal domain; Region: PapC_C; pfam13953
591946006480	putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253
591946006481	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591946006482	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591946006483	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591946006484	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
591946006485	antiporter inner membrane protein; Provisional; Region: PRK11670
591946006486	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
591946006487	Walker A motif; other site
591946006488	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
591946006489	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
591946006490	active site
591946006491	HIGH motif; other site
591946006492	KMSKS motif; other site
591946006493	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
591946006494	tRNA binding surface [nucleotide binding]; other site
591946006495	anticodon binding site; other site
591946006496	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
591946006497	dimer interface [polypeptide binding]; other site
591946006498	putative tRNA-binding site [nucleotide binding]; other site
591946006499	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
591946006500	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
591946006501	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
591946006502	MoxR-like ATPases [General function prediction only]; Region: COG0714
591946006503	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
591946006504	Walker A motif; other site
591946006505	ATP binding site [chemical binding]; other site
591946006506	Walker B motif; other site
591946006507	arginine finger; other site
591946006508	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
591946006509	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
591946006510	metal ion-dependent adhesion site (MIDAS); other site
591946006511	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
591946006512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
591946006513	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
591946006514	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
591946006515	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
591946006516	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946006517	active site
591946006518	phosphorylation site [posttranslational modification]
591946006519	intermolecular recognition site; other site
591946006520	dimerization interface [polypeptide binding]; other site
591946006521	LytTr DNA-binding domain; Region: LytTR; pfam04397
591946006522	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
591946006523	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
591946006524	GAF domain; Region: GAF; pfam01590
591946006525	Histidine kinase; Region: His_kinase; pfam06580
591946006526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946006527	ATP binding site [chemical binding]; other site
591946006528	Mg2+ binding site [ion binding]; other site
591946006529	G-X-G motif; other site
591946006530	transcriptional regulator MirA; Provisional; Region: PRK15043
591946006531	Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763
591946006532	DNA binding residues [nucleotide binding]
591946006533	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
591946006534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946006535	dimer interface [polypeptide binding]; other site
591946006536	conserved gate region; other site
591946006537	putative PBP binding loops; other site
591946006538	ABC-ATPase subunit interface; other site
591946006539	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
591946006540	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
591946006541	Walker A/P-loop; other site
591946006542	ATP binding site [chemical binding]; other site
591946006543	Q-loop/lid; other site
591946006544	ABC transporter signature motif; other site
591946006545	Walker B; other site
591946006546	D-loop; other site
591946006547	H-loop/switch region; other site
591946006548	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
591946006549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946006550	dimer interface [polypeptide binding]; other site
591946006551	conserved gate region; other site
591946006552	ABC-ATPase subunit interface; other site
591946006553	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
591946006554	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
591946006555	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
591946006556	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
591946006557	D-lactate dehydrogenase; Provisional; Region: PRK11183
591946006558	FAD binding domain; Region: FAD_binding_4; pfam01565
591946006559	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
591946006560	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
591946006561	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
591946006562	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
591946006563	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
591946006564	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
591946006565	oxidoreductase; Provisional; Region: PRK12743
591946006566	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591946006567	NAD(P) binding site [chemical binding]; other site
591946006568	active site
591946006569	multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459
591946006570	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
591946006571	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
591946006572	FMN binding site [chemical binding]; other site
591946006573	active site
591946006574	catalytic residues [active]
591946006575	substrate binding site [chemical binding]; other site
591946006576	hypothetical protein; Provisional; Region: PRK01821
591946006577	hypothetical protein; Provisional; Region: PRK10711
591946006578	cytidine deaminase; Provisional; Region: PRK09027
591946006579	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
591946006580	active site
591946006581	catalytic motif [active]
591946006582	Zn binding site [ion binding]; other site
591946006583	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
591946006584	active site
591946006585	catalytic motif [active]
591946006586	Zn binding site [ion binding]; other site
591946006587	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
591946006588	putative active site [active]
591946006589	Protein of unknown function (DUF2542); Region: DUF2542; pfam10808
591946006590	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
591946006591	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
591946006592	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946006593	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
591946006594	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
591946006595	homodimer interface [polypeptide binding]; other site
591946006596	active site
591946006597	FMN binding site [chemical binding]; other site
591946006598	substrate binding site [chemical binding]; other site
591946006599	4Fe-4S binding domain; Region: Fer4; pfam00037
591946006600	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591946006601	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591946006602	TM-ABC transporter signature motif; other site
591946006603	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591946006604	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
591946006605	Walker A/P-loop; other site
591946006606	ATP binding site [chemical binding]; other site
591946006607	Q-loop/lid; other site
591946006608	ABC transporter signature motif; other site
591946006609	Walker B; other site
591946006610	D-loop; other site
591946006611	H-loop/switch region; other site
591946006612	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591946006613	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
591946006614	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
591946006615	ligand binding site [chemical binding]; other site
591946006616	calcium binding site [ion binding]; other site
591946006617	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
591946006618	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946006619	DNA binding site [nucleotide binding]
591946006620	domain linker motif; other site
591946006621	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
591946006622	dimerization interface (closed form) [polypeptide binding]; other site
591946006623	ligand binding site [chemical binding]; other site
591946006624	Predicted membrane protein [Function unknown]; Region: COG2311
591946006625	hypothetical protein; Provisional; Region: PRK10835
591946006626	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
591946006627	homodecamer interface [polypeptide binding]; other site
591946006628	GTP cyclohydrolase I; Provisional; Region: PLN03044
591946006629	active site
591946006630	putative catalytic site residues [active]
591946006631	zinc binding site [ion binding]; other site
591946006632	GTP-CH-I/GFRP interaction surface; other site
591946006633	S-formylglutathione hydrolase; Region: PLN02442
591946006634	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
591946006635	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
591946006636	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591946006637	N-terminal plug; other site
591946006638	ligand-binding site [chemical binding]; other site
591946006639	lysine transporter; Provisional; Region: PRK10836
591946006640	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
591946006641	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946006642	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
591946006643	putative dimerization interface [polypeptide binding]; other site
591946006644	conserved hypothetical integral membrane protein; Region: TIGR00698
591946006645	endonuclease IV; Provisional; Region: PRK01060
591946006646	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
591946006647	AP (apurinic/apyrimidinic) site pocket; other site
591946006648	DNA interaction; other site
591946006649	Metal-binding active site; metal-binding site
591946006650	putative kinase; Provisional; Region: PRK09954
591946006651	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591946006652	putative DNA binding site [nucleotide binding]; other site
591946006653	putative Zn2+ binding site [ion binding]; other site
591946006654	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
591946006655	substrate binding site [chemical binding]; other site
591946006656	ATP binding site [chemical binding]; other site
591946006657	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
591946006658	active site
591946006659	tetramer interface [polypeptide binding]; other site
591946006660	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
591946006661	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
591946006662	ligand binding site [chemical binding]; other site
591946006663	flexible hinge region; other site
591946006664	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
591946006665	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
591946006666	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
591946006667	Nucleoside recognition; Region: Gate; pfam07670
591946006668	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
591946006669	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
591946006670	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
591946006671	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591946006672	substrate binding site [chemical binding]; other site
591946006673	ATP binding site [chemical binding]; other site
591946006674	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
591946006675	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
591946006676	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
591946006677	active site
591946006678	P-loop; other site
591946006679	phosphorylation site [posttranslational modification]
591946006680	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
591946006681	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
591946006682	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
591946006683	putative substrate binding site [chemical binding]; other site
591946006684	putative ATP binding site [chemical binding]; other site
591946006685	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
591946006686	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591946006687	active site
591946006688	phosphorylation site [posttranslational modification]
591946006689	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
591946006690	dimerization domain swap beta strand [polypeptide binding]; other site
591946006691	regulatory protein interface [polypeptide binding]; other site
591946006692	active site
591946006693	regulatory phosphorylation site [posttranslational modification]; other site
591946006694	sugar efflux transporter B; Provisional; Region: PRK15011
591946006695	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946006696	putative substrate translocation pore; other site
591946006697	Flagellin N-methylase; Region: FliB; pfam03692
591946006698	elongation factor P; Provisional; Region: PRK04542
591946006699	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
591946006700	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
591946006701	RNA binding site [nucleotide binding]; other site
591946006702	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
591946006703	RNA binding site [nucleotide binding]; other site
591946006704	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
591946006705	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
591946006706	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
591946006707	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
591946006708	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
591946006709	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
591946006710	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
591946006711	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
591946006712	active site
591946006713	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
591946006714	NlpC/P60 family; Region: NLPC_P60; pfam00877
591946006715	phage resistance protein; Provisional; Region: PRK10551
591946006716	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
591946006717	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946006718	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
591946006719	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
591946006720	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
591946006721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946006722	dimer interface [polypeptide binding]; other site
591946006723	conserved gate region; other site
591946006724	putative PBP binding loops; other site
591946006725	ABC-ATPase subunit interface; other site
591946006726	microcin C ABC transporter permease; Provisional; Region: PRK15021
591946006727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946006728	dimer interface [polypeptide binding]; other site
591946006729	conserved gate region; other site
591946006730	ABC-ATPase subunit interface; other site
591946006731	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
591946006732	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946006733	Walker A/P-loop; other site
591946006734	ATP binding site [chemical binding]; other site
591946006735	Q-loop/lid; other site
591946006736	ABC transporter signature motif; other site
591946006737	Walker B; other site
591946006738	D-loop; other site
591946006739	H-loop/switch region; other site
591946006740	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
591946006741	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946006742	Walker A/P-loop; other site
591946006743	ATP binding site [chemical binding]; other site
591946006744	Q-loop/lid; other site
591946006745	ABC transporter signature motif; other site
591946006746	Walker B; other site
591946006747	D-loop; other site
591946006748	H-loop/switch region; other site
591946006749	hypothetical protein; Provisional; Region: PRK11835
591946006750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946006751	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
591946006752	putative substrate translocation pore; other site
591946006753	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
591946006754	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591946006755	RNA binding surface [nucleotide binding]; other site
591946006756	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
591946006757	active site
591946006758	uracil binding [chemical binding]; other site
591946006759	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
591946006760	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591946006761	ATP binding site [chemical binding]; other site
591946006762	putative Mg++ binding site [ion binding]; other site
591946006763	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591946006764	nucleotide binding region [chemical binding]; other site
591946006765	ATP-binding site [chemical binding]; other site
591946006766	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
591946006767	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
591946006768	5S rRNA interface [nucleotide binding]; other site
591946006769	CTC domain interface [polypeptide binding]; other site
591946006770	L16 interface [polypeptide binding]; other site
591946006771	Nucleoid-associated protein [General function prediction only]; Region: COG3081
591946006772	nucleoid-associated protein NdpA; Validated; Region: PRK00378
591946006773	hypothetical protein; Provisional; Region: PRK13689
591946006774	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
591946006775	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
591946006776	Sulfatase; Region: Sulfatase; pfam00884
591946006777	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
591946006778	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
591946006779	transcriptional regulator NarP; Provisional; Region: PRK10403
591946006780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946006781	active site
591946006782	phosphorylation site [posttranslational modification]
591946006783	intermolecular recognition site; other site
591946006784	dimerization interface [polypeptide binding]; other site
591946006785	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946006786	DNA binding residues [nucleotide binding]
591946006787	dimerization interface [polypeptide binding]; other site
591946006788	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
591946006789	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
591946006790	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
591946006791	binding surface
591946006792	TPR motif; other site
591946006793	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
591946006794	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
591946006795	catalytic residues [active]
591946006796	central insert; other site
591946006797	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
591946006798	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
591946006799	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
591946006800	heme exporter protein CcmC; Region: ccmC; TIGR01191
591946006801	heme exporter protein CcmB; Region: ccmB; TIGR01190
591946006802	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
591946006803	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
591946006804	Walker A/P-loop; other site
591946006805	ATP binding site [chemical binding]; other site
591946006806	Q-loop/lid; other site
591946006807	ABC transporter signature motif; other site
591946006808	Walker B; other site
591946006809	D-loop; other site
591946006810	H-loop/switch region; other site
591946006811	cytochrome c-type protein NapC; Provisional; Region: PRK10617
591946006812	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
591946006813	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
591946006814	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
591946006815	4Fe-4S binding domain; Region: Fer4_5; pfam12801
591946006816	4Fe-4S binding domain; Region: Fer4_6; pfam12837
591946006817	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
591946006818	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
591946006819	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
591946006820	[4Fe-4S] binding site [ion binding]; other site
591946006821	molybdopterin cofactor binding site; other site
591946006822	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
591946006823	molybdopterin cofactor binding site; other site
591946006824	assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553
591946006825	ferredoxin-type protein; Provisional; Region: PRK10194
591946006826	tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750
591946006827	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
591946006828	secondary substrate binding site; other site
591946006829	primary substrate binding site; other site
591946006830	inhibition loop; other site
591946006831	dimerization interface [polypeptide binding]; other site
591946006832	malate:quinone oxidoreductase; Validated; Region: PRK05257
591946006833	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
591946006834	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
591946006835	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
591946006836	Walker A/P-loop; other site
591946006837	ATP binding site [chemical binding]; other site
591946006838	Q-loop/lid; other site
591946006839	ABC transporter signature motif; other site
591946006840	Walker B; other site
591946006841	D-loop; other site
591946006842	H-loop/switch region; other site
591946006843	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
591946006844	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
591946006845	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
591946006846	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946006847	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
591946006848	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
591946006849	DNA binding site [nucleotide binding]
591946006850	active site
591946006851	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
591946006852	ApbE family; Region: ApbE; pfam02424
591946006853	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591946006854	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591946006855	trimer interface [polypeptide binding]; other site
591946006856	eyelet of channel; other site
591946006857	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
591946006858	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946006859	ATP binding site [chemical binding]; other site
591946006860	G-X-G motif; other site
591946006861	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
591946006862	putative binding surface; other site
591946006863	active site
591946006864	transcriptional regulator RcsB; Provisional; Region: PRK10840
591946006865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946006866	active site
591946006867	phosphorylation site [posttranslational modification]
591946006868	intermolecular recognition site; other site
591946006869	dimerization interface [polypeptide binding]; other site
591946006870	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946006871	DNA binding residues [nucleotide binding]
591946006872	dimerization interface [polypeptide binding]; other site
591946006873	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
591946006874	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946006875	dimer interface [polypeptide binding]; other site
591946006876	phosphorylation site [posttranslational modification]
591946006877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946006878	ATP binding site [chemical binding]; other site
591946006879	Mg2+ binding site [ion binding]; other site
591946006880	G-X-G motif; other site
591946006881	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
591946006882	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946006883	active site
591946006884	phosphorylation site [posttranslational modification]
591946006885	intermolecular recognition site; other site
591946006886	dimerization interface [polypeptide binding]; other site
591946006887	sensory histidine kinase AtoS; Provisional; Region: PRK11360
591946006888	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591946006889	putative active site [active]
591946006890	heme pocket [chemical binding]; other site
591946006891	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946006892	dimer interface [polypeptide binding]; other site
591946006893	phosphorylation site [posttranslational modification]
591946006894	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946006895	ATP binding site [chemical binding]; other site
591946006896	Mg2+ binding site [ion binding]; other site
591946006897	G-X-G motif; other site
591946006898	acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361
591946006899	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946006900	active site
591946006901	phosphorylation site [posttranslational modification]
591946006902	intermolecular recognition site; other site
591946006903	dimerization interface [polypeptide binding]; other site
591946006904	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946006905	Walker A motif; other site
591946006906	ATP binding site [chemical binding]; other site
591946006907	Walker B motif; other site
591946006908	arginine finger; other site
591946006909	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
591946006910	acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920
591946006911	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
591946006912	Short chain fatty acid transporter; Region: SCFA_trans; pfam02667
591946006913	putative acyltransferase; Provisional; Region: PRK05790
591946006914	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
591946006915	dimer interface [polypeptide binding]; other site
591946006916	active site
591946006917	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
591946006918	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
591946006919	Predicted secreted protein [Function unknown]; Region: COG5445
591946006920	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
591946006921	Predicted secreted protein [Function unknown]; Region: COG5445
591946006922	Stage II sporulation protein; Region: SpoIID; pfam08486
591946006923	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
591946006924	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
591946006925	MG2 domain; Region: A2M_N; pfam01835
591946006926	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
591946006927	Alpha-2-macroglobulin family; Region: A2M; pfam00207
591946006928	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
591946006929	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234
591946006930	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685
591946006931	DNA gyrase subunit A; Validated; Region: PRK05560
591946006932	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
591946006933	CAP-like domain; other site
591946006934	active site
591946006935	primary dimer interface [polypeptide binding]; other site
591946006936	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591946006937	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591946006938	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591946006939	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591946006940	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591946006941	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591946006942	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
591946006943	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946006944	S-adenosylmethionine binding site [chemical binding]; other site
591946006945	adhesin; Provisional; Region: PRK09752
591946006946	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
591946006947	Autotransporter beta-domain; Region: Autotransporter; pfam03797
591946006948	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
591946006949	ATP cone domain; Region: ATP-cone; pfam03477
591946006950	Class I ribonucleotide reductase; Region: RNR_I; cd01679
591946006951	active site
591946006952	dimer interface [polypeptide binding]; other site
591946006953	catalytic residues [active]
591946006954	effector binding site; other site
591946006955	R2 peptide binding site; other site
591946006956	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
591946006957	dimer interface [polypeptide binding]; other site
591946006958	putative radical transfer pathway; other site
591946006959	diiron center [ion binding]; other site
591946006960	tyrosyl radical; other site
591946006961	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
591946006962	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
591946006963	catalytic loop [active]
591946006964	iron binding site [ion binding]; other site
591946006965	hypothetical protein; Provisional; Region: PRK09902
591946006966	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
591946006967	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
591946006968	active site
591946006969	catalytic site [active]
591946006970	metal binding site [ion binding]; metal-binding site
591946006971	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
591946006972	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946006973	putative substrate translocation pore; other site
591946006974	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
591946006975	hydroxyglutarate oxidase; Provisional; Region: PRK11728
591946006976	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
591946006977	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
591946006978	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
591946006979	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
591946006980	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591946006981	Cysteine-rich domain; Region: CCG; pfam02754
591946006982	Cysteine-rich domain; Region: CCG; pfam02754
591946006983	hypothetical protein; Provisional; Region: PRK09956
591946006984	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
591946006985	2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128
591946006986	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
591946006987	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946006988	putative substrate translocation pore; other site
591946006989	L-rhamnonate dehydratase; Provisional; Region: PRK15440
591946006990	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
591946006991	putative active site pocket [active]
591946006992	putative metal binding site [ion binding]; other site
591946006993	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
591946006994	Transcriptional regulator [Transcription]; Region: IclR; COG1414
591946006995	Bacterial transcriptional regulator; Region: IclR; pfam01614
591946006996	hypothetical protein; Provisional; Region: PRK03673
591946006997	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
591946006998	putative MPT binding site; other site
591946006999	Competence-damaged protein; Region: CinA; cl00666
591946007000	YfaZ precursor; Region: YfaZ; pfam07437
591946007001	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
591946007002	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
591946007003	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
591946007004	catalytic core [active]
591946007005	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
591946007006	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
591946007007	inhibitor-cofactor binding pocket; inhibition site
591946007008	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946007009	catalytic residue [active]
591946007010	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
591946007011	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
591946007012	Ligand binding site; other site
591946007013	Putative Catalytic site; other site
591946007014	DXD motif; other site
591946007015	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
591946007016	ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644
591946007017	substrate binding site [chemical binding]; other site
591946007018	cosubstrate binding site; other site
591946007019	catalytic site [active]
591946007020	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
591946007021	active site
591946007022	hexamer interface [polypeptide binding]; other site
591946007023	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
591946007024	NAD binding site [chemical binding]; other site
591946007025	substrate binding site [chemical binding]; other site
591946007026	active site
591946007027	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
591946007028	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
591946007029	putative active site [active]
591946007030	putative catalytic site [active]
591946007031	putative Zn binding site [ion binding]; other site
591946007032	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
591946007033	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
591946007034	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
591946007035	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
591946007036	signal transduction protein PmrD; Provisional; Region: PRK15450
591946007037	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
591946007038	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
591946007039	acyl-activating enzyme (AAE) consensus motif; other site
591946007040	putative AMP binding site [chemical binding]; other site
591946007041	putative active site [active]
591946007042	putative CoA binding site [chemical binding]; other site
591946007043	O-succinylbenzoate synthase; Provisional; Region: PRK05105
591946007044	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
591946007045	active site
591946007046	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
591946007047	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
591946007048	substrate binding site [chemical binding]; other site
591946007049	oxyanion hole (OAH) forming residues; other site
591946007050	trimer interface [polypeptide binding]; other site
591946007051	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
591946007052	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
591946007053	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
591946007054	dimer interface [polypeptide binding]; other site
591946007055	tetramer interface [polypeptide binding]; other site
591946007056	PYR/PP interface [polypeptide binding]; other site
591946007057	TPP binding site [chemical binding]; other site
591946007058	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
591946007059	TPP-binding site; other site
591946007060	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
591946007061	isochorismate synthases; Region: isochor_syn; TIGR00543
591946007062	hypothetical protein; Provisional; Region: PRK10404
591946007063	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946007064	Coenzyme A binding pocket [chemical binding]; other site
591946007065	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
591946007066	M28 Zn-Peptidases; Region: M28_like_1; cd05640
591946007067	Peptidase family M28; Region: Peptidase_M28; pfam04389
591946007068	metal binding site [ion binding]; metal-binding site
591946007069	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
591946007070	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
591946007071	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
591946007072	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
591946007073	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
591946007074	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
591946007075	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
591946007076	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
591946007077	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
591946007078	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
591946007079	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
591946007080	4Fe-4S binding domain; Region: Fer4; pfam00037
591946007081	4Fe-4S binding domain; Region: Fer4; pfam00037
591946007082	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
591946007083	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
591946007084	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
591946007085	catalytic loop [active]
591946007086	iron binding site [ion binding]; other site
591946007087	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
591946007088	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
591946007089	[4Fe-4S] binding site [ion binding]; other site
591946007090	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
591946007091	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
591946007092	SLBB domain; Region: SLBB; pfam10531
591946007093	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
591946007094	NADH dehydrogenase subunit E; Validated; Region: PRK07539
591946007095	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
591946007096	putative dimer interface [polypeptide binding]; other site
591946007097	[2Fe-2S] cluster binding site [ion binding]; other site
591946007098	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
591946007099	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
591946007100	NADH dehydrogenase subunit D; Validated; Region: PRK06075
591946007101	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
591946007102	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
591946007103	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
591946007104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946007105	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
591946007106	putative dimerization interface [polypeptide binding]; other site
591946007107	aminotransferase AlaT; Validated; Region: PRK09265
591946007108	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591946007109	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946007110	homodimer interface [polypeptide binding]; other site
591946007111	catalytic residue [active]
591946007112	5'-nucleotidase; Provisional; Region: PRK03826
591946007113	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
591946007114	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
591946007115	TrkA-C domain; Region: TrkA_C; pfam02080
591946007116	TrkA-C domain; Region: TrkA_C; pfam02080
591946007117	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
591946007118	putative phosphatase; Provisional; Region: PRK11587
591946007119	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946007120	motif II; other site
591946007121	hypothetical protein; Validated; Region: PRK05445
591946007122	hypothetical protein; Provisional; Region: PRK01816
591946007123	propionate/acetate kinase; Provisional; Region: PRK12379
591946007124	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
591946007125	phosphate acetyltransferase; Reviewed; Region: PRK05632
591946007126	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
591946007127	DRTGG domain; Region: DRTGG; pfam07085
591946007128	phosphate acetyltransferase; Region: pta; TIGR00651
591946007129	hypothetical protein; Provisional; Region: PRK11588
591946007130	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
591946007131	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
591946007132	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
591946007133	nudix motif; other site
591946007134	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
591946007135	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
591946007136	active site
591946007137	metal binding site [ion binding]; metal-binding site
591946007138	homotetramer interface [polypeptide binding]; other site
591946007139	glutathione S-transferase; Provisional; Region: PRK15113
591946007140	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
591946007141	C-terminal domain interface [polypeptide binding]; other site
591946007142	GSH binding site (G-site) [chemical binding]; other site
591946007143	dimer interface [polypeptide binding]; other site
591946007144	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
591946007145	N-terminal domain interface [polypeptide binding]; other site
591946007146	putative dimer interface [polypeptide binding]; other site
591946007147	putative substrate binding pocket (H-site) [chemical binding]; other site
591946007148	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
591946007149	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
591946007150	C-terminal domain interface [polypeptide binding]; other site
591946007151	GSH binding site (G-site) [chemical binding]; other site
591946007152	dimer interface [polypeptide binding]; other site
591946007153	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
591946007154	N-terminal domain interface [polypeptide binding]; other site
591946007155	putative dimer interface [polypeptide binding]; other site
591946007156	active site
591946007157	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
591946007158	homooctamer interface [polypeptide binding]; other site
591946007159	active site
591946007160	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
591946007161	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
591946007162	putative NAD(P) binding site [chemical binding]; other site
591946007163	putative active site [active]
591946007164	putative transposase; Provisional; Region: PRK09857
591946007165	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
591946007166	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
591946007167	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
591946007168	Walker A/P-loop; other site
591946007169	ATP binding site [chemical binding]; other site
591946007170	Q-loop/lid; other site
591946007171	ABC transporter signature motif; other site
591946007172	Walker B; other site
591946007173	D-loop; other site
591946007174	H-loop/switch region; other site
591946007175	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946007176	dimer interface [polypeptide binding]; other site
591946007177	conserved gate region; other site
591946007178	putative PBP binding loops; other site
591946007179	ABC-ATPase subunit interface; other site
591946007180	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591946007181	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946007182	dimer interface [polypeptide binding]; other site
591946007183	conserved gate region; other site
591946007184	putative PBP binding loops; other site
591946007185	ABC-ATPase subunit interface; other site
591946007186	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
591946007187	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946007188	substrate binding pocket [chemical binding]; other site
591946007189	membrane-bound complex binding site; other site
591946007190	hinge residues; other site
591946007191	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
591946007192	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946007193	substrate binding pocket [chemical binding]; other site
591946007194	membrane-bound complex binding site; other site
591946007195	hinge residues; other site
591946007196	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
591946007197	Flavoprotein; Region: Flavoprotein; pfam02441
591946007198	amidophosphoribosyltransferase; Provisional; Region: PRK09246
591946007199	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
591946007200	active site
591946007201	tetramer interface [polypeptide binding]; other site
591946007202	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591946007203	active site
591946007204	colicin V production protein; Provisional; Region: PRK10845
591946007205	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
591946007206	cell division protein DedD; Provisional; Region: PRK11633
591946007207	Sporulation related domain; Region: SPOR; pfam05036
591946007208	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
591946007209	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591946007210	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591946007211	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
591946007212	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
591946007213	hypothetical protein; Provisional; Region: PRK10847
591946007214	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
591946007215	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
591946007216	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
591946007217	dimerization interface 3.5A [polypeptide binding]; other site
591946007218	active site
591946007219	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
591946007220	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
591946007221	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
591946007222	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
591946007223	ligand binding site [chemical binding]; other site
591946007224	NAD binding site [chemical binding]; other site
591946007225	catalytic site [active]
591946007226	homodimer interface [polypeptide binding]; other site
591946007227	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
591946007228	putative transporter; Provisional; Region: PRK12382
591946007229	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946007230	putative substrate translocation pore; other site
591946007231	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
591946007232	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
591946007233	dimer interface [polypeptide binding]; other site
591946007234	active site
591946007235	Uncharacterized conserved protein [Function unknown]; Region: COG4121
591946007236	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
591946007237	YfcL protein; Region: YfcL; pfam08891
591946007238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
591946007239	hypothetical protein; Provisional; Region: PRK10621
591946007240	Predicted permeases [General function prediction only]; Region: COG0730
591946007241	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
591946007242	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
591946007243	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
591946007244	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
591946007245	Tetramer interface [polypeptide binding]; other site
591946007246	active site
591946007247	FMN-binding site [chemical binding]; other site
591946007248	HemK family putative methylases; Region: hemK_fam; TIGR00536
591946007249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946007250	S-adenosylmethionine binding site [chemical binding]; other site
591946007251	hypothetical protein; Provisional; Region: PRK04946
591946007252	Smr domain; Region: Smr; pfam01713
591946007253	Protein of unknown function (DUF2544); Region: DUF2544; pfam11245
591946007254	Fimbrial protein; Region: Fimbrial; cl01416
591946007255	Fimbrial protein; Region: Fimbrial; cl01416
591946007256	Fimbrial protein; Region: Fimbrial; cl01416
591946007257	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591946007258	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591946007259	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
591946007260	PapC N-terminal domain; Region: PapC_N; pfam13954
591946007261	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591946007262	PapC C-terminal domain; Region: PapC_C; pfam13953
591946007263	Fimbrial protein; Region: Fimbrial; cl01416
591946007264	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591946007265	catalytic core [active]
591946007266	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
591946007267	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
591946007268	substrate binding site [chemical binding]; other site
591946007269	oxyanion hole (OAH) forming residues; other site
591946007270	trimer interface [polypeptide binding]; other site
591946007271	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
591946007272	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
591946007273	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
591946007274	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
591946007275	dimer interface [polypeptide binding]; other site
591946007276	active site
591946007277	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
591946007278	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
591946007279	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
591946007280	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
591946007281	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
591946007282	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946007283	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
591946007284	dimerization interface [polypeptide binding]; other site
591946007285	substrate binding pocket [chemical binding]; other site
591946007286	permease DsdX; Provisional; Region: PRK09921
591946007287	gluconate transporter; Region: gntP; TIGR00791
591946007288	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
591946007289	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
591946007290	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591946007291	catalytic residue [active]
591946007292	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
591946007293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946007294	putative substrate translocation pore; other site
591946007295	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946007296	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
591946007297	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946007298	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946007299	DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958
591946007300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946007301	active site
591946007302	phosphorylation site [posttranslational modification]
591946007303	intermolecular recognition site; other site
591946007304	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946007305	DNA binding residues [nucleotide binding]
591946007306	dimerization interface [polypeptide binding]; other site
591946007307	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
591946007308	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946007309	substrate binding pocket [chemical binding]; other site
591946007310	membrane-bound complex binding site; other site
591946007311	hinge residues; other site
591946007312	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946007313	substrate binding pocket [chemical binding]; other site
591946007314	membrane-bound complex binding site; other site
591946007315	hinge residues; other site
591946007316	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946007317	dimer interface [polypeptide binding]; other site
591946007318	phosphorylation site [posttranslational modification]
591946007319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946007320	ATP binding site [chemical binding]; other site
591946007321	Mg2+ binding site [ion binding]; other site
591946007322	G-X-G motif; other site
591946007323	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946007324	active site
591946007325	phosphorylation site [posttranslational modification]
591946007326	intermolecular recognition site; other site
591946007327	dimerization interface [polypeptide binding]; other site
591946007328	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
591946007329	putative binding surface; other site
591946007330	active site
591946007331	putative CoA-transferase; Provisional; Region: PRK11430
591946007332	CoA-transferase family III; Region: CoA_transf_3; pfam02515
591946007333	putative transporter YfdV; Provisional; Region: PRK09903
591946007334	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
591946007335	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
591946007336	PYR/PP interface [polypeptide binding]; other site
591946007337	dimer interface [polypeptide binding]; other site
591946007338	TPP binding site [chemical binding]; other site
591946007339	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591946007340	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
591946007341	TPP-binding site; other site
591946007342	dimer interface [polypeptide binding]; other site
591946007343	formyl-coenzyme A transferase; Provisional; Region: PRK05398
591946007344	CoA-transferase family III; Region: CoA_transf_3; pfam02515
591946007345	hypothetical protein; Provisional; Region: PRK10316
591946007346	YfdX protein; Region: YfdX; pfam10938
591946007347	Protein of unknown function (DUF2545); Region: DUF2545; pfam10810
591946007348	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
591946007349	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
591946007350	putative acyl-acceptor binding pocket; other site
591946007351	aminotransferase; Validated; Region: PRK08175
591946007352	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591946007353	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946007354	homodimer interface [polypeptide binding]; other site
591946007355	catalytic residue [active]
591946007356	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
591946007357	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
591946007358	GAF domain; Region: GAF; cl17456
591946007359	Histidine kinase; Region: His_kinase; pfam06580
591946007360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946007361	ATP binding site [chemical binding]; other site
591946007362	Mg2+ binding site [ion binding]; other site
591946007363	G-X-G motif; other site
591946007364	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
591946007365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946007366	active site
591946007367	phosphorylation site [posttranslational modification]
591946007368	intermolecular recognition site; other site
591946007369	dimerization interface [polypeptide binding]; other site
591946007370	LytTr DNA-binding domain; Region: LytTR; pfam04397
591946007371	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591946007372	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946007373	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
591946007374	dimerization domain swap beta strand [polypeptide binding]; other site
591946007375	regulatory protein interface [polypeptide binding]; other site
591946007376	active site
591946007377	regulatory phosphorylation site [posttranslational modification]; other site
591946007378	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
591946007379	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
591946007380	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591946007381	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
591946007382	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591946007383	active site
591946007384	phosphorylation site [posttranslational modification]
591946007385	exoaminopeptidase; Provisional; Region: PRK09961
591946007386	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
591946007387	oligomer interface [polypeptide binding]; other site
591946007388	active site
591946007389	metal binding site [ion binding]; metal-binding site
591946007390	aminopeptidase; Provisional; Region: PRK09795
591946007391	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
591946007392	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
591946007393	active site
591946007394	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
591946007395	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
591946007396	active site
591946007397	P-loop; other site
591946007398	phosphorylation site [posttranslational modification]
591946007399	glucokinase, proteobacterial type; Region: glk; TIGR00749
591946007400	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591946007401	nucleotide binding site [chemical binding]; other site
591946007402	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
591946007403	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
591946007404	Cl- selectivity filter; other site
591946007405	Cl- binding residues [ion binding]; other site
591946007406	pore gating glutamate residue; other site
591946007407	dimer interface [polypeptide binding]; other site
591946007408	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
591946007409	manganese transport protein MntH; Reviewed; Region: PRK00701
591946007410	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
591946007411	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
591946007412	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
591946007413	Nucleoside recognition; Region: Gate; pfam07670
591946007414	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
591946007415	MASE1; Region: MASE1; pfam05231
591946007416	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591946007417	diguanylate cyclase; Region: GGDEF; smart00267
591946007418	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946007419	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
591946007420	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
591946007421	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
591946007422	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
591946007423	active site
591946007424	HIGH motif; other site
591946007425	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
591946007426	active site
591946007427	KMSKS motif; other site
591946007428	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
591946007429	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946007430	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
591946007431	putative dimerization interface [polypeptide binding]; other site
591946007432	putative substrate binding pocket [chemical binding]; other site
591946007433	nucleoside transporter; Region: 2A0110; TIGR00889
591946007434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946007435	putative substrate translocation pore; other site
591946007436	purine nucleoside phosphorylase; Provisional; Region: PRK08202
591946007437	hypothetical protein; Provisional; Region: PRK11528
591946007438	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591946007439	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946007440	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
591946007441	putative dimerization interface [polypeptide binding]; other site
591946007442	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
591946007443	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
591946007444	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530
591946007445	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
591946007446	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
591946007447	nucleotide binding pocket [chemical binding]; other site
591946007448	K-X-D-G motif; other site
591946007449	catalytic site [active]
591946007450	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
591946007451	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
591946007452	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
591946007453	Dimer interface [polypeptide binding]; other site
591946007454	BRCT sequence motif; other site
591946007455	cell division protein ZipA; Provisional; Region: PRK03427
591946007456	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
591946007457	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
591946007458	FtsZ protein binding site [polypeptide binding]; other site
591946007459	putative sulfate transport protein CysZ; Validated; Region: PRK04949
591946007460	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
591946007461	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
591946007462	dimer interface [polypeptide binding]; other site
591946007463	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946007464	catalytic residue [active]
591946007465	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
591946007466	dimerization domain swap beta strand [polypeptide binding]; other site
591946007467	regulatory protein interface [polypeptide binding]; other site
591946007468	active site
591946007469	regulatory phosphorylation site [posttranslational modification]; other site
591946007470	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
591946007471	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
591946007472	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591946007473	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
591946007474	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
591946007475	HPr interaction site; other site
591946007476	glycerol kinase (GK) interaction site [polypeptide binding]; other site
591946007477	active site
591946007478	phosphorylation site [posttranslational modification]
591946007479	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
591946007480	dimer interface [polypeptide binding]; other site
591946007481	pyridoxamine kinase; Validated; Region: PRK05756
591946007482	pyridoxal binding site [chemical binding]; other site
591946007483	ATP binding site [chemical binding]; other site
591946007484	hypothetical protein; Provisional; Region: PRK10318
591946007485	cysteine synthase B; Region: cysM; TIGR01138
591946007486	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
591946007487	dimer interface [polypeptide binding]; other site
591946007488	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946007489	catalytic residue [active]
591946007490	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
591946007491	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
591946007492	Walker A/P-loop; other site
591946007493	ATP binding site [chemical binding]; other site
591946007494	Q-loop/lid; other site
591946007495	ABC transporter signature motif; other site
591946007496	Walker B; other site
591946007497	D-loop; other site
591946007498	H-loop/switch region; other site
591946007499	TOBE-like domain; Region: TOBE_3; pfam12857
591946007500	sulfate transport protein; Provisional; Region: cysT; CHL00187
591946007501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946007502	dimer interface [polypeptide binding]; other site
591946007503	conserved gate region; other site
591946007504	putative PBP binding loops; other site
591946007505	ABC-ATPase subunit interface; other site
591946007506	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
591946007507	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946007508	dimer interface [polypeptide binding]; other site
591946007509	conserved gate region; other site
591946007510	putative PBP binding loops; other site
591946007511	ABC-ATPase subunit interface; other site
591946007512	thiosulfate transporter subunit; Provisional; Region: PRK10852
591946007513	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
591946007514	short chain dehydrogenase; Provisional; Region: PRK08226
591946007515	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
591946007516	NAD binding site [chemical binding]; other site
591946007517	homotetramer interface [polypeptide binding]; other site
591946007518	homodimer interface [polypeptide binding]; other site
591946007519	active site
591946007520	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
591946007521	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
591946007522	putative active site [active]
591946007523	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
591946007524	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591946007525	active site turn [active]
591946007526	phosphorylation site [posttranslational modification]
591946007527	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591946007528	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
591946007529	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
591946007530	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
591946007531	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
591946007532	putative acetyltransferase; Provisional; Region: PRK03624
591946007533	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946007534	Coenzyme A binding pocket [chemical binding]; other site
591946007535	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
591946007536	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
591946007537	active site
591946007538	metal binding site [ion binding]; metal-binding site
591946007539	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
591946007540	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
591946007541	transcriptional regulator EutR; Provisional; Region: PRK10130
591946007542	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946007543	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946007544	carboxysome structural protein EutK; Provisional; Region: PRK15466
591946007545	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
591946007546	Hexamer interface [polypeptide binding]; other site
591946007547	Hexagonal pore residue; other site
591946007548	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
591946007549	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
591946007550	putative hexamer interface [polypeptide binding]; other site
591946007551	putative hexagonal pore; other site
591946007552	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
591946007553	putative hexamer interface [polypeptide binding]; other site
591946007554	putative hexagonal pore; other site
591946007555	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
591946007556	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
591946007557	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
591946007558	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
591946007559	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
591946007560	ethanol dehydrogenase EutG; Provisional; Region: PRK15454
591946007561	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
591946007562	active site
591946007563	metal binding site [ion binding]; metal-binding site
591946007564	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
591946007565	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591946007566	nucleotide binding site [chemical binding]; other site
591946007567	aldehyde dehydrogenase EutE; Provisional; Region: PRK15398
591946007568	NAD(P) binding site [chemical binding]; other site
591946007569	catalytic residues [active]
591946007570	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
591946007571	Hexamer/Pentamer interface [polypeptide binding]; other site
591946007572	central pore; other site
591946007573	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
591946007574	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
591946007575	Hexamer interface [polypeptide binding]; other site
591946007576	Hexagonal pore residue; other site
591946007577	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
591946007578	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
591946007579	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
591946007580	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766
591946007581	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
591946007582	G1 box; other site
591946007583	GTP/Mg2+ binding site [chemical binding]; other site
591946007584	G2 box; other site
591946007585	Switch I region; other site
591946007586	G3 box; other site
591946007587	Switch II region; other site
591946007588	G4 box; other site
591946007589	G5 box; other site
591946007590	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
591946007591	putative hexamer interface [polypeptide binding]; other site
591946007592	putative hexagonal pore; other site
591946007593	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
591946007594	Malic enzyme, N-terminal domain; Region: malic; pfam00390
591946007595	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
591946007596	putative NAD(P) binding site [chemical binding]; other site
591946007597	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
591946007598	transaldolase-like protein; Provisional; Region: PTZ00411
591946007599	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
591946007600	active site
591946007601	dimer interface [polypeptide binding]; other site
591946007602	catalytic residue [active]
591946007603	transketolase; Reviewed; Region: PRK12753
591946007604	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
591946007605	TPP-binding site [chemical binding]; other site
591946007606	dimer interface [polypeptide binding]; other site
591946007607	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
591946007608	PYR/PP interface [polypeptide binding]; other site
591946007609	dimer interface [polypeptide binding]; other site
591946007610	TPP binding site [chemical binding]; other site
591946007611	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
591946007612	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
591946007613	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
591946007614	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
591946007615	dimer interface [polypeptide binding]; other site
591946007616	ADP-ribose binding site [chemical binding]; other site
591946007617	active site
591946007618	nudix motif; other site
591946007619	metal binding site [ion binding]; metal-binding site
591946007620	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
591946007621	4Fe-4S binding domain; Region: Fer4; pfam00037
591946007622	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
591946007623	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946007624	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
591946007625	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
591946007626	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591946007627	dimerization interface [polypeptide binding]; other site
591946007628	Histidine kinase; Region: HisKA_3; pfam07730
591946007629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946007630	ATP binding site [chemical binding]; other site
591946007631	Mg2+ binding site [ion binding]; other site
591946007632	G-X-G motif; other site
591946007633	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
591946007634	Protein export membrane protein; Region: SecD_SecF; cl14618
591946007635	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
591946007636	ArsC family; Region: ArsC; pfam03960
591946007637	putative catalytic residues [active]
591946007638	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
591946007639	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
591946007640	metal binding site [ion binding]; metal-binding site
591946007641	dimer interface [polypeptide binding]; other site
591946007642	hypothetical protein; Provisional; Region: PRK13664
591946007643	putative hydrolase; Provisional; Region: PRK11460
591946007644	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
591946007645	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
591946007646	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
591946007647	Helicase; Region: Helicase_RecD; pfam05127
591946007648	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
591946007649	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
591946007650	Predicted metalloprotease [General function prediction only]; Region: COG2321
591946007651	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
591946007652	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
591946007653	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
591946007654	ATP binding site [chemical binding]; other site
591946007655	active site
591946007656	substrate binding site [chemical binding]; other site
591946007657	lipoprotein; Provisional; Region: PRK11679
591946007658	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
591946007659	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
591946007660	dihydrodipicolinate synthase; Region: dapA; TIGR00674
591946007661	dimer interface [polypeptide binding]; other site
591946007662	active site
591946007663	catalytic residue [active]
591946007664	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
591946007665	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
591946007666	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
591946007667	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
591946007668	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
591946007669	catalytic triad [active]
591946007670	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
591946007671	Domain of unknown function DUF20; Region: UPF0118; pfam01594
591946007672	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
591946007673	Peptidase family M48; Region: Peptidase_M48; cl12018
591946007674	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
591946007675	ArsC family; Region: ArsC; pfam03960
591946007676	catalytic residues [active]
591946007677	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
591946007678	DNA replication initiation factor; Provisional; Region: PRK08084
591946007679	uracil transporter; Provisional; Region: PRK10720
591946007680	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591946007681	active site
591946007682	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
591946007683	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
591946007684	dimerization interface [polypeptide binding]; other site
591946007685	putative ATP binding site [chemical binding]; other site
591946007686	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
591946007687	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
591946007688	active site
591946007689	substrate binding site [chemical binding]; other site
591946007690	cosubstrate binding site; other site
591946007691	catalytic site [active]
591946007692	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
591946007693	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
591946007694	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
591946007695	Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114
591946007696	domain interface [polypeptide binding]; other site
591946007697	active site
591946007698	catalytic site [active]
591946007699	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
591946007700	putative active site [active]
591946007701	catalytic site [active]
591946007702	exopolyphosphatase; Provisional; Region: PRK10854
591946007703	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
591946007704	MASE1; Region: MASE1; pfam05231
591946007705	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591946007706	diguanylate cyclase; Region: GGDEF; smart00267
591946007707	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946007708	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
591946007709	GMP synthase; Reviewed; Region: guaA; PRK00074
591946007710	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
591946007711	AMP/PPi binding site [chemical binding]; other site
591946007712	candidate oxyanion hole; other site
591946007713	catalytic triad [active]
591946007714	potential glutamine specificity residues [chemical binding]; other site
591946007715	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
591946007716	ATP Binding subdomain [chemical binding]; other site
591946007717	Ligand Binding sites [chemical binding]; other site
591946007718	Dimerization subdomain; other site
591946007719	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
591946007720	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
591946007721	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
591946007722	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
591946007723	active site
591946007724	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
591946007725	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
591946007726	generic binding surface II; other site
591946007727	generic binding surface I; other site
591946007728	RatA-like protein; Provisional; Region: PRK15316
591946007729	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
591946007730	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
591946007731	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
591946007732	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
591946007733	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
591946007734	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
591946007735	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
591946007736	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
591946007737	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
591946007738	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
591946007739	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
591946007740	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
591946007741	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
591946007742	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
591946007743	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
591946007744	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
591946007745	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
591946007746	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
591946007747	intimin-like protein SinH; Provisional; Region: PRK15318
591946007748	intimin-like protein SinH; Provisional; Region: PRK15318
591946007749	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
591946007750	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
591946007751	GTP-binding protein Der; Reviewed; Region: PRK00093
591946007752	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
591946007753	G1 box; other site
591946007754	GTP/Mg2+ binding site [chemical binding]; other site
591946007755	Switch I region; other site
591946007756	G2 box; other site
591946007757	Switch II region; other site
591946007758	G3 box; other site
591946007759	G4 box; other site
591946007760	G5 box; other site
591946007761	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
591946007762	G1 box; other site
591946007763	GTP/Mg2+ binding site [chemical binding]; other site
591946007764	Switch I region; other site
591946007765	G2 box; other site
591946007766	G3 box; other site
591946007767	Switch II region; other site
591946007768	G4 box; other site
591946007769	G5 box; other site
591946007770	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
591946007771	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216
591946007772	Trp docking motif [polypeptide binding]; other site
591946007773	active site
591946007774	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
591946007775	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
591946007776	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
591946007777	dimer interface [polypeptide binding]; other site
591946007778	motif 1; other site
591946007779	active site
591946007780	motif 2; other site
591946007781	motif 3; other site
591946007782	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
591946007783	anticodon binding site; other site
591946007784	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
591946007785	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
591946007786	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
591946007787	cytoskeletal protein RodZ; Provisional; Region: PRK10856
591946007788	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946007789	non-specific DNA binding site [nucleotide binding]; other site
591946007790	salt bridge; other site
591946007791	sequence-specific DNA binding site [nucleotide binding]; other site
591946007792	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
591946007793	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
591946007794	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946007795	FeS/SAM binding site; other site
591946007796	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
591946007797	active site
591946007798	multimer interface [polypeptide binding]; other site
591946007799	penicillin-binding protein 1C; Provisional; Region: PRK11240
591946007800	Transglycosylase; Region: Transgly; pfam00912
591946007801	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
591946007802	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
591946007803	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
591946007804	MG2 domain; Region: A2M_N; pfam01835
591946007805	Alpha-2-macroglobulin family; Region: A2M; pfam00207
591946007806	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
591946007807	surface patch; other site
591946007808	thioester region; other site
591946007809	specificity defining residues; other site
591946007810	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
591946007811	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
591946007812	active site residue [active]
591946007813	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
591946007814	active site residue [active]
591946007815	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
591946007816	aminopeptidase B; Provisional; Region: PRK05015
591946007817	Peptidase; Region: DUF3663; pfam12404
591946007818	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
591946007819	interface (dimer of trimers) [polypeptide binding]; other site
591946007820	Substrate-binding/catalytic site; other site
591946007821	Zn-binding sites [ion binding]; other site
591946007822	hypothetical protein; Provisional; Region: PRK10721
591946007823	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
591946007824	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
591946007825	catalytic loop [active]
591946007826	iron binding site [ion binding]; other site
591946007827	chaperone protein HscA; Provisional; Region: hscA; PRK05183
591946007828	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
591946007829	nucleotide binding site [chemical binding]; other site
591946007830	putative NEF/HSP70 interaction site [polypeptide binding]; other site
591946007831	SBD interface [polypeptide binding]; other site
591946007832	co-chaperone HscB; Provisional; Region: hscB; PRK05014
591946007833	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
591946007834	HSP70 interaction site [polypeptide binding]; other site
591946007835	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
591946007836	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
591946007837	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
591946007838	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
591946007839	trimerization site [polypeptide binding]; other site
591946007840	active site
591946007841	cysteine desulfurase; Provisional; Region: PRK14012
591946007842	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
591946007843	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591946007844	catalytic residue [active]
591946007845	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
591946007846	Rrf2 family protein; Region: rrf2_super; TIGR00738
591946007847	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
591946007848	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
591946007849	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
591946007850	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
591946007851	active site
591946007852	dimerization interface [polypeptide binding]; other site
591946007853	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
591946007854	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
591946007855	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
591946007856	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
591946007857	PRD domain; Region: PRD; pfam00874
591946007858	PRD domain; Region: PRD; pfam00874
591946007859	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
591946007860	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946007861	putative substrate translocation pore; other site
591946007862	Predicted membrane protein [Function unknown]; Region: COG2259
591946007863	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
591946007864	active site
591946007865	catalytic residues [active]
591946007866	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591946007867	L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239
591946007868	putative NAD(P) binding site [chemical binding]; other site
591946007869	catalytic Zn binding site [ion binding]; other site
591946007870	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591946007871	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591946007872	TM-ABC transporter signature motif; other site
591946007873	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
591946007874	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591946007875	Walker A/P-loop; other site
591946007876	ATP binding site [chemical binding]; other site
591946007877	Q-loop/lid; other site
591946007878	ABC transporter signature motif; other site
591946007879	Walker B; other site
591946007880	D-loop; other site
591946007881	H-loop/switch region; other site
591946007882	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591946007883	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
591946007884	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
591946007885	ligand binding site [chemical binding]; other site
591946007886	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591946007887	TPR motif; other site
591946007888	binding surface
591946007889	TPR repeat; Region: TPR_11; pfam13414
591946007890	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591946007891	TPR motif; other site
591946007892	binding surface
591946007893	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
591946007894	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591946007895	nucleotide binding site [chemical binding]; other site
591946007896	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
591946007897	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
591946007898	dimer interface [polypeptide binding]; other site
591946007899	active site
591946007900	glycine-pyridoxal phosphate binding site [chemical binding]; other site
591946007901	folate binding site [chemical binding]; other site
591946007902	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
591946007903	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
591946007904	heme-binding site [chemical binding]; other site
591946007905	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
591946007906	FAD binding pocket [chemical binding]; other site
591946007907	FAD binding motif [chemical binding]; other site
591946007908	phosphate binding motif [ion binding]; other site
591946007909	beta-alpha-beta structure motif; other site
591946007910	NAD binding pocket [chemical binding]; other site
591946007911	Heme binding  pocket [chemical binding]; other site
591946007912	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
591946007913	Nitrogen regulatory protein P-II; Region: P-II; smart00938
591946007914	response regulator GlrR; Provisional; Region: PRK15115
591946007915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946007916	active site
591946007917	phosphorylation site [posttranslational modification]
591946007918	intermolecular recognition site; other site
591946007919	dimerization interface [polypeptide binding]; other site
591946007920	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946007921	Walker A motif; other site
591946007922	ATP binding site [chemical binding]; other site
591946007923	Walker B motif; other site
591946007924	arginine finger; other site
591946007925	hypothetical protein; Provisional; Region: PRK10722
591946007926	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
591946007927	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946007928	dimer interface [polypeptide binding]; other site
591946007929	phosphorylation site [posttranslational modification]
591946007930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946007931	ATP binding site [chemical binding]; other site
591946007932	Mg2+ binding site [ion binding]; other site
591946007933	G-X-G motif; other site
591946007934	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
591946007935	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
591946007936	dimerization interface [polypeptide binding]; other site
591946007937	ATP binding site [chemical binding]; other site
591946007938	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
591946007939	dimerization interface [polypeptide binding]; other site
591946007940	ATP binding site [chemical binding]; other site
591946007941	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
591946007942	putative active site [active]
591946007943	catalytic triad [active]
591946007944	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
591946007945	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946007946	substrate binding pocket [chemical binding]; other site
591946007947	membrane-bound complex binding site; other site
591946007948	hinge residues; other site
591946007949	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591946007950	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591946007951	catalytic residue [active]
591946007952	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
591946007953	nucleoside/Zn binding site; other site
591946007954	dimer interface [polypeptide binding]; other site
591946007955	catalytic motif [active]
591946007956	hypothetical protein; Provisional; Region: PRK11590
591946007957	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
591946007958	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
591946007959	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
591946007960	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
591946007961	putative active site [active]
591946007962	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
591946007963	holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516
591946007964	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
591946007965	active site
591946007966	hydrophilic channel; other site
591946007967	dimerization interface [polypeptide binding]; other site
591946007968	catalytic residues [active]
591946007969	active site lid [active]
591946007970	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
591946007971	Recombination protein O N terminal; Region: RecO_N; pfam11967
591946007972	Recombination protein O C terminal; Region: RecO_C; pfam02565
591946007973	GTPase Era; Reviewed; Region: era; PRK00089
591946007974	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
591946007975	G1 box; other site
591946007976	GTP/Mg2+ binding site [chemical binding]; other site
591946007977	Switch I region; other site
591946007978	G2 box; other site
591946007979	Switch II region; other site
591946007980	G3 box; other site
591946007981	G4 box; other site
591946007982	G5 box; other site
591946007983	KH domain; Region: KH_2; pfam07650
591946007984	ribonuclease III; Reviewed; Region: rnc; PRK00102
591946007985	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
591946007986	dimerization interface [polypeptide binding]; other site
591946007987	active site
591946007988	metal binding site [ion binding]; metal-binding site
591946007989	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
591946007990	dsRNA binding site [nucleotide binding]; other site
591946007991	signal peptidase I; Provisional; Region: PRK10861
591946007992	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
591946007993	Catalytic site [active]
591946007994	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
591946007995	GTP-binding protein LepA; Provisional; Region: PRK05433
591946007996	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
591946007997	G1 box; other site
591946007998	putative GEF interaction site [polypeptide binding]; other site
591946007999	GTP/Mg2+ binding site [chemical binding]; other site
591946008000	Switch I region; other site
591946008001	G2 box; other site
591946008002	G3 box; other site
591946008003	Switch II region; other site
591946008004	G4 box; other site
591946008005	G5 box; other site
591946008006	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
591946008007	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
591946008008	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
591946008009	SoxR reducing system protein RseC; Provisional; Region: PRK10862
591946008010	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
591946008011	anti-sigma E factor; Provisional; Region: rseB; PRK09455
591946008012	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
591946008013	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
591946008014	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
591946008015	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
591946008016	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
591946008017	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
591946008018	DNA binding residues [nucleotide binding]
591946008019	L-aspartate oxidase; Provisional; Region: PRK09077
591946008020	L-aspartate oxidase; Provisional; Region: PRK06175
591946008021	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
591946008022	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
591946008023	Methyltransferase domain; Region: Methyltransf_26; pfam13659
591946008024	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
591946008025	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
591946008026	ATP binding site [chemical binding]; other site
591946008027	Mg++ binding site [ion binding]; other site
591946008028	motif III; other site
591946008029	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591946008030	nucleotide binding region [chemical binding]; other site
591946008031	ATP-binding site [chemical binding]; other site
591946008032	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591946008033	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946008034	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
591946008035	dimerization interface [polypeptide binding]; other site
591946008036	cysteine/O-acetylserine exporter; Provisional; Region: PRK10323
591946008037	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
591946008038	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
591946008039	ligand binding site [chemical binding]; other site
591946008040	active site
591946008041	UGI interface [polypeptide binding]; other site
591946008042	catalytic site [active]
591946008043	putative methyltransferase; Provisional; Region: PRK10864
591946008044	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
591946008045	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
591946008046	thioredoxin 2; Provisional; Region: PRK10996
591946008047	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
591946008048	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
591946008049	catalytic residues [active]
591946008050	Uncharacterized conserved protein [Function unknown]; Region: COG3148
591946008051	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
591946008052	CoA binding domain; Region: CoA_binding_2; pfam13380
591946008053	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
591946008054	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
591946008055	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
591946008056	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
591946008057	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
591946008058	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
591946008059	domain interface [polypeptide binding]; other site
591946008060	putative active site [active]
591946008061	catalytic site [active]
591946008062	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
591946008063	domain interface [polypeptide binding]; other site
591946008064	putative active site [active]
591946008065	catalytic site [active]
591946008066	lipoprotein; Provisional; Region: PRK10759
591946008067	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
591946008068	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946008069	putative substrate translocation pore; other site
591946008070	corresponding to LF82_p379 in publication : Miquel et al., PLoS One; 536; 55989; APEC_01; E24377A; ED1a; HS; IAI1; S88; SE11; UTI89
591946008071	HTH-like domain; Region: HTH_21; pfam13276
591946008072	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
591946008073	Integrase core domain; Region: rve; pfam00665
591946008074	Integrase core domain; Region: rve_2; pfam13333
591946008075	protein disaggregation chaperone; Provisional; Region: PRK10865
591946008076	Clp amino terminal domain; Region: Clp_N; pfam02861
591946008077	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946008078	Walker A motif; other site
591946008079	ATP binding site [chemical binding]; other site
591946008080	Walker B motif; other site
591946008081	arginine finger; other site
591946008082	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946008083	Walker A motif; other site
591946008084	ATP binding site [chemical binding]; other site
591946008085	Walker B motif; other site
591946008086	arginine finger; other site
591946008087	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
591946008088	hypothetical protein; Provisional; Region: PRK10723
591946008089	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
591946008090	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
591946008091	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591946008092	RNA binding surface [nucleotide binding]; other site
591946008093	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
591946008094	active site
591946008095	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
591946008096	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
591946008097	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
591946008098	30S subunit binding site; other site
591946008099	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
591946008100	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
591946008101	Prephenate dehydratase; Region: PDT; pfam00800
591946008102	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
591946008103	putative L-Phe binding site [chemical binding]; other site
591946008104	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
591946008105	Chorismate mutase type II; Region: CM_2; cl00693
591946008106	prephenate dehydrogenase; Validated; Region: PRK08507
591946008107	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
591946008108	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
591946008109	lipoprotein; Provisional; Region: PRK11443
591946008110	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
591946008111	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
591946008112	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
591946008113	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946008114	metal binding site [ion binding]; metal-binding site
591946008115	active site
591946008116	I-site; other site
591946008117	putative outer membrane lipoprotein; Provisional; Region: PRK09967
591946008118	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
591946008119	ligand binding site [chemical binding]; other site
591946008120	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
591946008121	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
591946008122	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
591946008123	RimM N-terminal domain; Region: RimM; pfam01782
591946008124	PRC-barrel domain; Region: PRC; pfam05239
591946008125	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
591946008126	signal recognition particle protein; Provisional; Region: PRK10867
591946008127	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
591946008128	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
591946008129	P loop; other site
591946008130	GTP binding site [chemical binding]; other site
591946008131	Signal peptide binding domain; Region: SRP_SPB; pfam02978
591946008132	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
591946008133	hypothetical protein; Provisional; Region: PRK11573
591946008134	Domain of unknown function DUF21; Region: DUF21; pfam01595
591946008135	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
591946008136	Transporter associated domain; Region: CorC_HlyC; smart01091
591946008137	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
591946008138	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
591946008139	dimer interface [polypeptide binding]; other site
591946008140	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
591946008141	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
591946008142	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
591946008143	recombination and repair protein; Provisional; Region: PRK10869
591946008144	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
591946008145	Walker A/P-loop; other site
591946008146	ATP binding site [chemical binding]; other site
591946008147	Q-loop/lid; other site
591946008148	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
591946008149	Q-loop/lid; other site
591946008150	ABC transporter signature motif; other site
591946008151	Walker B; other site
591946008152	D-loop; other site
591946008153	H-loop/switch region; other site
591946008154	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
591946008155	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
591946008156	hypothetical protein; Validated; Region: PRK01777
591946008157	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
591946008158	putative coenzyme Q binding site [chemical binding]; other site
591946008159	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
591946008160	SmpB-tmRNA interface; other site
591946008161	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
591946008162	tail protein; Provisional; Region: D; PHA02561
591946008163	Phage protein U [General function prediction only]; Region: COG3499
591946008164	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
591946008165	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
591946008166	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
591946008167	major tail tube protein; Provisional; Region: FII; PHA02600
591946008168	major tail sheath protein; Provisional; Region: FI; PHA02560
591946008169	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
591946008170	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
591946008171	catalytic residues [active]
591946008172	catalytic nucleophile [active]
591946008173	Presynaptic Site I dimer interface [polypeptide binding]; other site
591946008174	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
591946008175	Synaptic Flat tetramer interface [polypeptide binding]; other site
591946008176	Synaptic Site I dimer interface [polypeptide binding]; other site
591946008177	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
591946008178	DNA-binding interface [nucleotide binding]; DNA binding site
591946008179	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
591946008180	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
591946008181	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
591946008182	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
591946008183	baseplate assembly protein; Provisional; Region: J; PHA02568
591946008184	baseplate wedge subunit; Provisional; Region: W; PHA02516
591946008185	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
591946008186	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
591946008187	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
591946008188	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
591946008189	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
591946008190	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
591946008191	catalytic residues [active]
591946008192	P2-like prophage tail protein X [General function prediction only]; Region: COG5004
591946008193	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
591946008194	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
591946008195	capsid protein; Provisional; Region: N; PHA02538
591946008196	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929
591946008197	terminase ATPase subunit; Provisional; Region: P; PHA02535
591946008198	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
591946008199	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
591946008200	portal vertex protein; Provisional; Region: Q; PHA02536
591946008201	Phage portal protein; Region: Phage_portal; pfam04860
591946008202	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
591946008203	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
591946008204	DinI-like family; Region: DinI; pfam06183
591946008205	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
591946008206	DNA adenine methylase (dam); Region: dam; TIGR00571
591946008207	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
591946008208	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
591946008209	Protein of unknown function (DUF2724); Region: DUF2724; pfam10893
591946008210	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
591946008211	Predicted transcriptional regulator [Transcription]; Region: COG2932
591946008212	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
591946008213	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
591946008214	Catalytic site [active]
591946008215	integrase; Provisional; Region: int; PHA02601
591946008216	Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family.  They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797
591946008217	dimer interface [polypeptide binding]; other site
591946008218	active site
591946008219	catalytic residues [active]
591946008220	Int/Topo IB signature motif; other site
591946008221	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
591946008222	substrate binding pocket [chemical binding]; other site
591946008223	active site
591946008224	iron coordination sites [ion binding]; other site
591946008225	Predicted dehydrogenase [General function prediction only]; Region: COG0579
591946008226	hydroxyglutarate oxidase; Provisional; Region: PRK11728
591946008227	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
591946008228	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
591946008229	tetramerization interface [polypeptide binding]; other site
591946008230	NAD(P) binding site [chemical binding]; other site
591946008231	catalytic residues [active]
591946008232	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
591946008233	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
591946008234	inhibitor-cofactor binding pocket; inhibition site
591946008235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946008236	catalytic residue [active]
591946008237	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
591946008238	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
591946008239	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946008240	DNA-binding site [nucleotide binding]; DNA binding site
591946008241	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591946008242	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
591946008243	bacterial OsmY and nodulation domain; Region: BON; smart00749
591946008244	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591946008245	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
591946008246	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591946008247	dimerization interface [polypeptide binding]; other site
591946008248	putative DNA binding site [nucleotide binding]; other site
591946008249	Transcriptional regulators [Transcription]; Region: MarR; COG1846
591946008250	putative Zn2+ binding site [ion binding]; other site
591946008251	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527
591946008252	active site residue [active]
591946008253	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
591946008254	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
591946008255	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
591946008256	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
591946008257	hypothetical protein; Provisional; Region: PRK10556
591946008258	hypothetical protein; Provisional; Region: PRK10132
591946008259	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
591946008260	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946008261	DNA-binding site [nucleotide binding]; DNA binding site
591946008262	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591946008263	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946008264	homodimer interface [polypeptide binding]; other site
591946008265	catalytic residue [active]
591946008266	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
591946008267	Uncharacterized conserved protein [Function unknown]; Region: COG2128
591946008268	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
591946008269	catalytic residues [active]
591946008270	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
591946008271	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
591946008272	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
591946008273	Class I ribonucleotide reductase; Region: RNR_I; cd01679
591946008274	active site
591946008275	dimer interface [polypeptide binding]; other site
591946008276	catalytic residues [active]
591946008277	effector binding site; other site
591946008278	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
591946008279	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
591946008280	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
591946008281	dimer interface [polypeptide binding]; other site
591946008282	putative radical transfer pathway; other site
591946008283	diiron center [ion binding]; other site
591946008284	tyrosyl radical; other site
591946008285	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
591946008286	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
591946008287	Walker A/P-loop; other site
591946008288	ATP binding site [chemical binding]; other site
591946008289	Q-loop/lid; other site
591946008290	ABC transporter signature motif; other site
591946008291	Walker B; other site
591946008292	D-loop; other site
591946008293	H-loop/switch region; other site
591946008294	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
591946008295	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
591946008296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946008297	dimer interface [polypeptide binding]; other site
591946008298	conserved gate region; other site
591946008299	putative PBP binding loops; other site
591946008300	ABC-ATPase subunit interface; other site
591946008301	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
591946008302	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
591946008303	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
591946008304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946008305	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
591946008306	putative L-valine exporter; Provisional; Region: PRK10408
591946008307	transcriptional repressor MprA; Provisional; Region: PRK10870
591946008308	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
591946008309	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
591946008310	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946008311	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946008312	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
591946008313	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946008314	putative substrate translocation pore; other site
591946008315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946008316	S-ribosylhomocysteinase; Provisional; Region: PRK02260
591946008317	glutamate--cysteine ligase; Provisional; Region: PRK02107
591946008318	Predicted membrane protein [Function unknown]; Region: COG1238
591946008319	Phosphatase yqaB
591946008320	carbon storage regulator; Provisional; Region: PRK01712
591946008321	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
591946008322	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
591946008323	motif 1; other site
591946008324	active site
591946008325	motif 2; other site
591946008326	motif 3; other site
591946008327	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
591946008328	DHHA1 domain; Region: DHHA1; pfam02272
591946008329	recombination regulator RecX; Reviewed; Region: recX; PRK00117
591946008330	recombinase A; Provisional; Region: recA; PRK09354
591946008331	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
591946008332	hexamer interface [polypeptide binding]; other site
591946008333	Walker A motif; other site
591946008334	ATP binding site [chemical binding]; other site
591946008335	Walker B motif; other site
591946008336	hypothetical protein; Validated; Region: PRK03661
591946008337	Transglycosylase SLT domain; Region: SLT_2; pfam13406
591946008338	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591946008339	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591946008340	PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821
591946008341	PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825
591946008342	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
591946008343	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
591946008344	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
591946008345	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
591946008346	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
591946008347	putative NAD(P) binding site [chemical binding]; other site
591946008348	active site
591946008349	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
591946008350	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
591946008351	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
591946008352	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946008353	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
591946008354	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
591946008355	putative active site [active]
591946008356	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
591946008357	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
591946008358	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
591946008359	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946008360	Walker A motif; other site
591946008361	ATP binding site [chemical binding]; other site
591946008362	Walker B motif; other site
591946008363	arginine finger; other site
591946008364	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
591946008365	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
591946008366	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
591946008367	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
591946008368	iron binding site [ion binding]; other site
591946008369	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
591946008370	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591946008371	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946008372	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
591946008373	Acylphosphatase; Region: Acylphosphatase; pfam00708
591946008374	HypF finger; Region: zf-HYPF; pfam07503
591946008375	HypF finger; Region: zf-HYPF; pfam07503
591946008376	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
591946008377	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
591946008378	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
591946008379	Transcriptional regulators [Transcription]; Region: PurR; COG1609
591946008380	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946008381	DNA binding site [nucleotide binding]
591946008382	domain linker motif; other site
591946008383	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
591946008384	dimerization interface (closed form) [polypeptide binding]; other site
591946008385	ligand binding site [chemical binding]; other site
591946008386	PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796
591946008387	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591946008388	active site turn [active]
591946008389	phosphorylation site [posttranslational modification]
591946008390	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
591946008391	cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852
591946008392	beta-galactosidase; Region: BGL; TIGR03356
591946008393	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
591946008394	nickel binding site [ion binding]; other site
591946008395	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
591946008396	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
591946008397	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
591946008398	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591946008399	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
591946008400	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
591946008401	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
591946008402	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
591946008403	NADH dehydrogenase; Region: NADHdh; cl00469
591946008404	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
591946008405	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
591946008406	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
591946008407	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
591946008408	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
591946008409	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
591946008410	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
591946008411	hydrogenase assembly chaperone; Provisional; Region: PRK10409
591946008412	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
591946008413	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
591946008414	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
591946008415	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
591946008416	dimerization interface [polypeptide binding]; other site
591946008417	ATP binding site [chemical binding]; other site
591946008418	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
591946008419	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
591946008420	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
591946008421	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946008422	Walker A motif; other site
591946008423	ATP binding site [chemical binding]; other site
591946008424	Walker B motif; other site
591946008425	arginine finger; other site
591946008426	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
591946008427	molybdenum-pterin binding domain; Region: Mop; TIGR00638
591946008428	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
591946008429	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
591946008430	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
591946008431	MutS domain I; Region: MutS_I; pfam01624
591946008432	MutS domain II; Region: MutS_II; pfam05188
591946008433	MutS domain III; Region: MutS_III; pfam05192
591946008434	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
591946008435	Walker A/P-loop; other site
591946008436	ATP binding site [chemical binding]; other site
591946008437	Q-loop/lid; other site
591946008438	ABC transporter signature motif; other site
591946008439	Walker B; other site
591946008440	D-loop; other site
591946008441	H-loop/switch region; other site
591946008442	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
591946008443	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
591946008444	active site
591946008445	metal binding site [ion binding]; metal-binding site
591946008446	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591946008447	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
591946008448	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946008449	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
591946008450	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
591946008451	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
591946008452	putative aldolase; Validated; Region: PRK08130
591946008453	active site
591946008454	intersubunit interface [polypeptide binding]; other site
591946008455	Zn2+ binding site [ion binding]; other site
591946008456	hypothetical protein; Provisional; Region: PRK09989
591946008457	putative transporter; Provisional; Region: PRK09821
591946008458	GntP family permease; Region: GntP_permease; pfam02447
591946008459	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
591946008460	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
591946008461	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
591946008462	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
591946008463	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
591946008464	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
591946008465	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
591946008466	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
591946008467	DNA binding residues [nucleotide binding]
591946008468	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
591946008469	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591946008470	Peptidase family M23; Region: Peptidase_M23; pfam01551
591946008471	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
591946008472	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946008473	S-adenosylmethionine binding site [chemical binding]; other site
591946008474	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
591946008475	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
591946008476	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
591946008477	Permutation of conserved domain; other site
591946008478	active site
591946008479	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
591946008480	homotrimer interaction site [polypeptide binding]; other site
591946008481	zinc binding site [ion binding]; other site
591946008482	CDP-binding sites; other site
591946008483	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
591946008484	substrate binding site; other site
591946008485	dimer interface; other site
591946008486	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
591946008487	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
591946008488	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
591946008489	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
591946008490	ligand-binding site [chemical binding]; other site
591946008491	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
591946008492	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
591946008493	CysD dimerization site [polypeptide binding]; other site
591946008494	G1 box; other site
591946008495	putative GEF interaction site [polypeptide binding]; other site
591946008496	GTP/Mg2+ binding site [chemical binding]; other site
591946008497	Switch I region; other site
591946008498	G2 box; other site
591946008499	G3 box; other site
591946008500	Switch II region; other site
591946008501	G4 box; other site
591946008502	G5 box; other site
591946008503	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
591946008504	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
591946008505	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
591946008506	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
591946008507	Active Sites [active]
591946008508	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
591946008509	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
591946008510	metal binding site [ion binding]; metal-binding site
591946008511	Hok/gef family; Region: HOK_GEF; pfam01848
591946008512	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
591946008513	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
591946008514	Active Sites [active]
591946008515	sulfite reductase subunit beta; Provisional; Region: PRK13504
591946008516	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
591946008517	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
591946008518	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
591946008519	Flavodoxin; Region: Flavodoxin_1; pfam00258
591946008520	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
591946008521	FAD binding pocket [chemical binding]; other site
591946008522	FAD binding motif [chemical binding]; other site
591946008523	catalytic residues [active]
591946008524	NAD binding pocket [chemical binding]; other site
591946008525	phosphate binding motif [ion binding]; other site
591946008526	beta-alpha-beta structure motif; other site
591946008527	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
591946008528	active site
591946008529	putative oxidoreductase FixC; Provisional; Region: PRK10157
591946008530	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
591946008531	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
591946008532	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
591946008533	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
591946008534	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
591946008535	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
591946008536	Ligand binding site [chemical binding]; other site
591946008537	Electron transfer flavoprotein domain; Region: ETF; pfam01012
591946008538	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
591946008539	benzoate transport; Region: 2A0115; TIGR00895
591946008540	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946008541	putative substrate translocation pore; other site
591946008542	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
591946008543	FAD binding domain; Region: FAD_binding_4; pfam01565
591946008544	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
591946008545	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
591946008546	NADP binding site [chemical binding]; other site
591946008547	homodimer interface [polypeptide binding]; other site
591946008548	active site
591946008549	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591946008550	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946008551	putative substrate translocation pore; other site
591946008552	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
591946008553	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
591946008554	nucleotide binding site [chemical binding]; other site
591946008555	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
591946008556	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
591946008557	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
591946008558	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
591946008559	Repair protein; Region: Repair_PSII; pfam04536
591946008560	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
591946008561	Repair protein; Region: Repair_PSII; pfam04536
591946008562	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
591946008563	Repair protein; Region: Repair_PSII; pfam04536
591946008564	enolase; Provisional; Region: eno; PRK00077
591946008565	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
591946008566	dimer interface [polypeptide binding]; other site
591946008567	metal binding site [ion binding]; metal-binding site
591946008568	substrate binding pocket [chemical binding]; other site
591946008569	CTP synthetase; Validated; Region: pyrG; PRK05380
591946008570	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
591946008571	Catalytic site [active]
591946008572	active site
591946008573	UTP binding site [chemical binding]; other site
591946008574	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
591946008575	active site
591946008576	putative oxyanion hole; other site
591946008577	catalytic triad [active]
591946008578	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
591946008579	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
591946008580	homodimer interface [polypeptide binding]; other site
591946008581	metal binding site [ion binding]; metal-binding site
591946008582	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
591946008583	homodimer interface [polypeptide binding]; other site
591946008584	active site
591946008585	putative chemical substrate binding site [chemical binding]; other site
591946008586	metal binding site [ion binding]; metal-binding site
591946008587	toxin MazF; Provisional; Region: PRK09907
591946008588	antitoxin MazE; Provisional; Region: PRK09798
591946008589	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
591946008590	HD domain; Region: HD_4; pfam13328
591946008591	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
591946008592	synthetase active site [active]
591946008593	NTP binding site [chemical binding]; other site
591946008594	metal binding site [ion binding]; metal-binding site
591946008595	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
591946008596	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
591946008597	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
591946008598	TRAM domain; Region: TRAM; pfam01938
591946008599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946008600	S-adenosylmethionine binding site [chemical binding]; other site
591946008601	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
591946008602	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
591946008603	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591946008604	dimerization interface [polypeptide binding]; other site
591946008605	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946008606	dimer interface [polypeptide binding]; other site
591946008607	phosphorylation site [posttranslational modification]
591946008608	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946008609	ATP binding site [chemical binding]; other site
591946008610	Mg2+ binding site [ion binding]; other site
591946008611	G-X-G motif; other site
591946008612	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
591946008613	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946008614	active site
591946008615	phosphorylation site [posttranslational modification]
591946008616	intermolecular recognition site; other site
591946008617	dimerization interface [polypeptide binding]; other site
591946008618	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
591946008619	putative binding surface; other site
591946008620	active site
591946008621	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
591946008622	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
591946008623	active site
591946008624	tetramer interface [polypeptide binding]; other site
591946008625	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
591946008626	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
591946008627	active site
591946008628	tetramer interface [polypeptide binding]; other site
591946008629	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946008630	D-galactonate transporter; Region: 2A0114; TIGR00893
591946008631	putative substrate translocation pore; other site
591946008632	flavodoxin; Provisional; Region: PRK08105
591946008633	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
591946008634	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
591946008635	probable active site [active]
591946008636	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
591946008637	SecY interacting protein Syd; Provisional; Region: PRK04968
591946008638	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
591946008639	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
591946008640	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
591946008641	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
591946008642	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
591946008643	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
591946008644	serine transporter; Region: stp; TIGR00814
591946008645	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
591946008646	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
591946008647	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
591946008648	flap endonuclease-like protein; Provisional; Region: PRK09482
591946008649	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
591946008650	active site
591946008651	metal binding site 1 [ion binding]; metal-binding site
591946008652	putative 5' ssDNA interaction site; other site
591946008653	metal binding site 3; metal-binding site
591946008654	metal binding site 2 [ion binding]; metal-binding site
591946008655	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
591946008656	putative DNA binding site [nucleotide binding]; other site
591946008657	putative metal binding site [ion binding]; other site
591946008658	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
591946008659	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
591946008660	dimer interface [polypeptide binding]; other site
591946008661	active site
591946008662	metal binding site [ion binding]; metal-binding site
591946008663	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
591946008664	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
591946008665	intersubunit interface [polypeptide binding]; other site
591946008666	active site
591946008667	Zn2+ binding site [ion binding]; other site
591946008668	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
591946008669	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946008670	putative substrate translocation pore; other site
591946008671	L-fucose isomerase; Provisional; Region: fucI; PRK10991
591946008672	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
591946008673	hexamer (dimer of trimers) interface [polypeptide binding]; other site
591946008674	trimer interface [polypeptide binding]; other site
591946008675	substrate binding site [chemical binding]; other site
591946008676	Mn binding site [ion binding]; other site
591946008677	L-fuculokinase; Provisional; Region: PRK10331
591946008678	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
591946008679	nucleotide binding site [chemical binding]; other site
591946008680	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
591946008681	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
591946008682	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
591946008683	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946008684	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
591946008685	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
591946008686	hypothetical protein; Provisional; Region: PRK10873
591946008687	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
591946008688	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946008689	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
591946008690	dimerization interface [polypeptide binding]; other site
591946008691	substrate binding pocket [chemical binding]; other site
591946008692	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
591946008693	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
591946008694	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
591946008695	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591946008696	catalytic residue [active]
591946008697	CsdA-binding activator; Provisional; Region: PRK15019
591946008698	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
591946008699	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
591946008700	putative ATP binding site [chemical binding]; other site
591946008701	putative substrate interface [chemical binding]; other site
591946008702	murein transglycosylase A; Provisional; Region: mltA; PRK11162
591946008703	MltA specific insert domain; Region: MltA; pfam03562
591946008704	3D domain; Region: 3D; pfam06725
591946008705	Protein of unknown function (DUF770); Region: DUF770; pfam05591
591946008706	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
591946008707	Protein of unknown function (DUF877); Region: DUF877; pfam05943
591946008708	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
591946008709	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
591946008710	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
591946008711	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
591946008712	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
591946008713	ligand binding site [chemical binding]; other site
591946008714	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
591946008715	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
591946008716	Clp amino terminal domain; Region: Clp_N; pfam02861
591946008717	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946008718	Walker A motif; other site
591946008719	ATP binding site [chemical binding]; other site
591946008720	Walker B motif; other site
591946008721	arginine finger; other site
591946008722	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946008723	Walker A motif; other site
591946008724	ATP binding site [chemical binding]; other site
591946008725	Walker B motif; other site
591946008726	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
591946008727	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
591946008728	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
591946008729	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
591946008730	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
591946008731	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
591946008732	PAAR motif; Region: PAAR_motif; pfam05488
591946008733	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
591946008734	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
591946008735	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
591946008736	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
591946008737	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
591946008738	PAAR motif; Region: PAAR_motif; pfam05488
591946008739	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
591946008740	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
591946008741	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
591946008742	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
591946008743	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
591946008744	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
591946008745	ImpA domain protein; Region: DUF3702; pfam12486
591946008746	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
591946008747	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
591946008748	putative ligand binding site [chemical binding]; other site
591946008749	putative NAD binding site [chemical binding]; other site
591946008750	catalytic site [active]
591946008751	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
591946008752	putative active site [active]
591946008753	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
591946008754	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591946008755	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946008756	homodimer interface [polypeptide binding]; other site
591946008757	catalytic residue [active]
591946008758	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
591946008759	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591946008760	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591946008761	active site turn [active]
591946008762	phosphorylation site [posttranslational modification]
591946008763	CAT RNA binding domain; Region: CAT_RBD; pfam03123
591946008764	PRD domain; Region: PRD; pfam00874
591946008765	PRD domain; Region: PRD; pfam00874
591946008766	AMIN domain; Region: AMIN; pfam11741
591946008767	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
591946008768	active site
591946008769	metal binding site [ion binding]; metal-binding site
591946008770	N-acetylglutamate synthase; Validated; Region: PRK05279
591946008771	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
591946008772	putative feedback inhibition sensing region; other site
591946008773	putative nucleotide binding site [chemical binding]; other site
591946008774	putative substrate binding site [chemical binding]; other site
591946008775	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946008776	Coenzyme A binding pocket [chemical binding]; other site
591946008777	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
591946008778	AAA domain; Region: AAA_30; pfam13604
591946008779	Family description; Region: UvrD_C_2; pfam13538
591946008780	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
591946008781	protease3; Provisional; Region: PRK15101
591946008782	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
591946008783	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
591946008784	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
591946008785	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
591946008786	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
591946008787	hypothetical protein; Provisional; Region: PRK10332
591946008788	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
591946008789	hypothetical protein; Provisional; Region: PRK11521
591946008790	hypothetical protein; Provisional; Region: PRK10557
591946008791	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
591946008792	hypothetical protein; Provisional; Region: PRK10506
591946008793	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
591946008794	thymidylate synthase; Reviewed; Region: thyA; PRK01827
591946008795	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
591946008796	dimerization interface [polypeptide binding]; other site
591946008797	active site
591946008798	prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544
591946008799	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
591946008800	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
591946008801	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
591946008802	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591946008803	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
591946008804	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
591946008805	putative active site [active]
591946008806	Ap4A binding site [chemical binding]; other site
591946008807	nudix motif; other site
591946008808	putative metal binding site [ion binding]; other site
591946008809	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
591946008810	putative DNA-binding cleft [nucleotide binding]; other site
591946008811	putative DNA clevage site; other site
591946008812	molecular lever; other site
591946008813	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
591946008814	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
591946008815	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591946008816	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591946008817	active site
591946008818	catalytic tetrad [active]
591946008819	lysophospholipid transporter LplT; Provisional; Region: PRK11195
591946008820	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946008821	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
591946008822	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
591946008823	putative acyl-acceptor binding pocket; other site
591946008824	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
591946008825	acyl-activating enzyme (AAE) consensus motif; other site
591946008826	putative AMP binding site [chemical binding]; other site
591946008827	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
591946008828	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946008829	DNA binding site [nucleotide binding]
591946008830	domain linker motif; other site
591946008831	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
591946008832	dimerization interface (closed form) [polypeptide binding]; other site
591946008833	ligand binding site [chemical binding]; other site
591946008834	diaminopimelate decarboxylase; Provisional; Region: PRK11165
591946008835	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
591946008836	active site
591946008837	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591946008838	substrate binding site [chemical binding]; other site
591946008839	catalytic residues [active]
591946008840	dimer interface [polypeptide binding]; other site
591946008841	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
591946008842	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946008843	The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456
591946008844	putative dimerization interface [polypeptide binding]; other site
591946008845	putative racemase; Provisional; Region: PRK10200
591946008846	aspartate racemase; Region: asp_race; TIGR00035
591946008847	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
591946008848	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946008849	putative substrate translocation pore; other site
591946008850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946008851	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
591946008852	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
591946008853	NADP binding site [chemical binding]; other site
591946008854	homodimer interface [polypeptide binding]; other site
591946008855	active site
591946008856	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
591946008857	putative acyltransferase; Provisional; Region: PRK05790
591946008858	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
591946008859	dimer interface [polypeptide binding]; other site
591946008860	active site
591946008861	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
591946008862	serine transporter; Region: stp; TIGR00814
591946008863	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591946008864	Peptidase family M23; Region: Peptidase_M23; pfam01551
591946008865	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
591946008866	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
591946008867	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
591946008868	xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971
591946008869	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
591946008870	xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908
591946008871	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
591946008872	catalytic loop [active]
591946008873	iron binding site [ion binding]; other site
591946008874	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
591946008875	GAF domain; Region: GAF; cl17456
591946008876	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
591946008877	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591946008878	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946008879	Walker A motif; other site
591946008880	ATP binding site [chemical binding]; other site
591946008881	Walker B motif; other site
591946008882	arginine finger; other site
591946008883	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
591946008884	aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200
591946008885	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
591946008886	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
591946008887	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
591946008888	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
591946008889	catalytic residue [active]
591946008890	peptidase; Reviewed; Region: PRK13004
591946008891	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
591946008892	putative metal binding site [ion binding]; other site
591946008893	putative dimer interface [polypeptide binding]; other site
591946008894	D-hydantoinase; Region: D-hydantoinase; TIGR02033
591946008895	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
591946008896	tetramer interface [polypeptide binding]; other site
591946008897	active site
591946008898	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
591946008899	carbamate kinase; Reviewed; Region: PRK12686
591946008900	putative substrate binding site [chemical binding]; other site
591946008901	homodimer interface [polypeptide binding]; other site
591946008902	nucleotide binding site [chemical binding]; other site
591946008903	nucleotide binding site [chemical binding]; other site
591946008904	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
591946008905	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
591946008906	XdhC Rossmann domain; Region: XdhC_C; pfam13478
591946008907	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
591946008908	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
591946008909	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
591946008910	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
591946008911	Ligand binding site; other site
591946008912	metal-binding site
591946008913	putative selenate reductase subunit YgfK; Provisional; Region: PRK09853
591946008914	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
591946008915	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591946008916	putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314
591946008917	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
591946008918	active site
591946008919	putative substrate binding pocket [chemical binding]; other site
591946008920	probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312
591946008921	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
591946008922	putative hypoxanthine oxidase; Provisional; Region: PRK09800
591946008923	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
591946008924	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
591946008925	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
591946008926	uracil-xanthine permease; Region: ncs2; TIGR00801
591946008927	guanine deaminase; Provisional; Region: PRK09228
591946008928	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
591946008929	active site
591946008930	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
591946008931	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
591946008932	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809
591946008933	4Fe-4S binding domain; Region: Fer4; pfam00037
591946008934	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
591946008935	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946008936	xanthine permease; Region: pbuX; TIGR03173
591946008937	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
591946008938	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
591946008939	active site
591946008940	metal binding site [ion binding]; metal-binding site
591946008941	nudix motif; other site
591946008942	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
591946008943	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
591946008944	dimer interface [polypeptide binding]; other site
591946008945	putative anticodon binding site; other site
591946008946	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
591946008947	motif 1; other site
591946008948	active site
591946008949	motif 2; other site
591946008950	motif 3; other site
591946008951	peptide chain release factor 2; Provisional; Region: PRK08787
591946008952	This domain is found in peptide chain release factors; Region: PCRF; smart00937
591946008953	RF-1 domain; Region: RF-1; pfam00472
591946008954	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
591946008955	DHH family; Region: DHH; pfam01368
591946008956	DHHA1 domain; Region: DHHA1; pfam02272
591946008957	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
591946008958	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
591946008959	dimerization domain [polypeptide binding]; other site
591946008960	dimer interface [polypeptide binding]; other site
591946008961	catalytic residues [active]
591946008962	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
591946008963	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
591946008964	active site
591946008965	Int/Topo IB signature motif; other site
591946008966	flavodoxin FldB; Provisional; Region: PRK12359
591946008967	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
591946008968	hypothetical protein; Provisional; Region: PRK10878
591946008969	putative global regulator; Reviewed; Region: PRK09559
591946008970	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
591946008971	hemolysin; Provisional; Region: PRK15087
591946008972	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
591946008973	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
591946008974	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
591946008975	beta-galactosidase; Region: BGL; TIGR03356
591946008976	glycine dehydrogenase; Provisional; Region: PRK05367
591946008977	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
591946008978	tetramer interface [polypeptide binding]; other site
591946008979	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946008980	catalytic residue [active]
591946008981	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
591946008982	tetramer interface [polypeptide binding]; other site
591946008983	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946008984	catalytic residue [active]
591946008985	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
591946008986	lipoyl attachment site [posttranslational modification]; other site
591946008987	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
591946008988	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
591946008989	oxidoreductase; Provisional; Region: PRK08013
591946008990	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
591946008991	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
591946008992	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
591946008993	proline aminopeptidase P II; Provisional; Region: PRK10879
591946008994	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
591946008995	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
591946008996	active site
591946008997	hypothetical protein; Reviewed; Region: PRK01736
591946008998	Z-ring-associated protein; Provisional; Region: PRK10972
591946008999	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
591946009000	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
591946009001	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
591946009002	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
591946009003	ligand binding site [chemical binding]; other site
591946009004	NAD binding site [chemical binding]; other site
591946009005	tetramer interface [polypeptide binding]; other site
591946009006	catalytic site [active]
591946009007	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
591946009008	L-serine binding site [chemical binding]; other site
591946009009	ACT domain interface; other site
591946009010	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
591946009011	tetramer (dimer of dimers) interface [polypeptide binding]; other site
591946009012	active site
591946009013	dimer interface [polypeptide binding]; other site
591946009014	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591946009015	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
591946009016	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946009017	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
591946009018	putative dimerization interface [polypeptide binding]; other site
591946009019	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
591946009020	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946009021	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591946009022	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591946009023	dimerization interface [polypeptide binding]; other site
591946009024	Uncharacterized conserved protein [Function unknown]; Region: COG2968
591946009025	oxidative stress defense protein; Provisional; Region: PRK11087
591946009026	arginine exporter protein; Provisional; Region: PRK09304
591946009027	mechanosensitive channel MscS; Provisional; Region: PRK10334
591946009028	Mechanosensitive ion channel; Region: MS_channel; pfam00924
591946009029	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
591946009030	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
591946009031	active site
591946009032	intersubunit interface [polypeptide binding]; other site
591946009033	zinc binding site [ion binding]; other site
591946009034	Na+ binding site [ion binding]; other site
591946009035	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
591946009036	Phosphoglycerate kinase; Region: PGK; pfam00162
591946009037	substrate binding site [chemical binding]; other site
591946009038	hinge regions; other site
591946009039	ADP binding site [chemical binding]; other site
591946009040	catalytic site [active]
591946009041	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
591946009042	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
591946009043	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
591946009044	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
591946009045	trimer interface [polypeptide binding]; other site
591946009046	putative Zn binding site [ion binding]; other site
591946009047	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
591946009048	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
591946009049	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
591946009050	Walker A/P-loop; other site
591946009051	ATP binding site [chemical binding]; other site
591946009052	Q-loop/lid; other site
591946009053	ABC transporter signature motif; other site
591946009054	Walker B; other site
591946009055	D-loop; other site
591946009056	H-loop/switch region; other site
591946009057	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
591946009058	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
591946009059	Walker A/P-loop; other site
591946009060	ATP binding site [chemical binding]; other site
591946009061	Q-loop/lid; other site
591946009062	ABC transporter signature motif; other site
591946009063	Walker B; other site
591946009064	D-loop; other site
591946009065	H-loop/switch region; other site
591946009066	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
591946009067	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
591946009068	active site
591946009069	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
591946009070	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022
591946009071	potential frameshift: common BLAST hit: gi|254162841|ref|YP_003045949.1| fructose-1,6-bisphosphatase II-like protein
591946009072	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
591946009073	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
591946009074	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
591946009075	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591946009076	putative NAD(P) binding site [chemical binding]; other site
591946009077	catalytic Zn binding site [ion binding]; other site
591946009078	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
591946009079	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
591946009080	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
591946009081	active site
591946009082	P-loop; other site
591946009083	phosphorylation site [posttranslational modification]
591946009084	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591946009085	active site
591946009086	phosphorylation site [posttranslational modification]
591946009087	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
591946009088	SPFH domain / Band 7 family; Region: Band_7; pfam01145
591946009089	transketolase; Reviewed; Region: PRK12753
591946009090	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
591946009091	TPP-binding site [chemical binding]; other site
591946009092	dimer interface [polypeptide binding]; other site
591946009093	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
591946009094	PYR/PP interface [polypeptide binding]; other site
591946009095	dimer interface [polypeptide binding]; other site
591946009096	TPP binding site [chemical binding]; other site
591946009097	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
591946009098	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
591946009099	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
591946009100	agmatinase; Region: agmatinase; TIGR01230
591946009101	oligomer interface [polypeptide binding]; other site
591946009102	putative active site [active]
591946009103	Mn binding site [ion binding]; other site
591946009104	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
591946009105	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
591946009106	dimer interface [polypeptide binding]; other site
591946009107	active site
591946009108	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591946009109	catalytic residues [active]
591946009110	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
591946009111	Virulence promoting factor; Region: YqgB; pfam11036
591946009112	Protein of unknown function (DUF2684); Region: DUF2684; pfam10885
591946009113	S-adenosylmethionine synthetase; Validated; Region: PRK05250
591946009114	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
591946009115	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
591946009116	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
591946009117	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
591946009118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946009119	putative substrate translocation pore; other site
591946009120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946009121	hypothetical protein; Provisional; Region: PRK04860
591946009122	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
591946009123	DNA-specific endonuclease I; Provisional; Region: PRK15137
591946009124	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
591946009125	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
591946009126	RNA methyltransferase, RsmE family; Region: TIGR00046
591946009127	glutathione synthetase; Provisional; Region: PRK05246
591946009128	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
591946009129	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
591946009130	hypothetical protein; Validated; Region: PRK00228
591946009131	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
591946009132	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
591946009133	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
591946009134	Walker A motif; other site
591946009135	ATP binding site [chemical binding]; other site
591946009136	Walker B motif; other site
591946009137	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
591946009138	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591946009139	catalytic residue [active]
591946009140	YGGT family; Region: YGGT; pfam02325
591946009141	YGGT family; Region: YGGT; pfam02325
591946009142	hypothetical protein; Validated; Region: PRK05090
591946009143	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
591946009144	active site
591946009145	dimerization interface [polypeptide binding]; other site
591946009146	HemN family oxidoreductase; Provisional; Region: PRK05660
591946009147	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946009148	FeS/SAM binding site; other site
591946009149	HemN C-terminal domain; Region: HemN_C; pfam06969
591946009150	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
591946009151	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
591946009152	homodimer interface [polypeptide binding]; other site
591946009153	active site
591946009154	hypothetical protein; Provisional; Region: PRK10626
591946009155	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
591946009156	hypothetical protein; Provisional; Region: PRK11702
591946009157	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
591946009158	adenine DNA glycosylase; Provisional; Region: PRK10880
591946009159	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
591946009160	minor groove reading motif; other site
591946009161	helix-hairpin-helix signature motif; other site
591946009162	substrate binding pocket [chemical binding]; other site
591946009163	active site
591946009164	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
591946009165	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
591946009166	DNA binding and oxoG recognition site [nucleotide binding]
591946009167	oxidative damage protection protein; Provisional; Region: PRK05408
591946009168	murein transglycosylase C; Provisional; Region: mltC; PRK11671
591946009169	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
591946009170	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591946009171	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591946009172	catalytic residue [active]
591946009173	nucleoside transporter; Region: 2A0110; TIGR00889
591946009174	ornithine decarboxylase; Provisional; Region: PRK13578
591946009175	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
591946009176	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
591946009177	homodimer interface [polypeptide binding]; other site
591946009178	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946009179	catalytic residue [active]
591946009180	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
591946009181	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
591946009182	KpsF/GutQ family protein; Region: kpsF; TIGR00393
591946009183	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
591946009184	putative active site [active]
591946009185	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
591946009186	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
591946009187	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
591946009188	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
591946009189	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
591946009190	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
591946009191	Ligand binding site; other site
591946009192	oligomer interface; other site
591946009193	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563
591946009194	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
591946009195	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
591946009196	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
591946009197	MULE transposase domain; Region: MULE; pfam10551
591946009198	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591946009199	TPR motif; other site
591946009200	TPR repeat; Region: TPR_11; pfam13414
591946009201	binding surface
591946009202	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
591946009203	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
591946009204	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
591946009205	active site
591946009206	nucleotide binding site [chemical binding]; other site
591946009207	HIGH motif; other site
591946009208	KMSKS motif; other site
591946009209	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
591946009210	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
591946009211	Walker A/P-loop; other site
591946009212	ATP binding site [chemical binding]; other site
591946009213	Q-loop/lid; other site
591946009214	ABC transporter signature motif; other site
591946009215	Walker B; other site
591946009216	D-loop; other site
591946009217	H-loop/switch region; other site
591946009218	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
591946009219	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
591946009220	putative general secretion pathway protein YghD; Provisional; Region: PRK09731
591946009221	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
591946009222	GspL-like protein; Provisional; Region: PRK09662
591946009223	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
591946009224	type II secretion system protein J; Region: gspJ; TIGR01711
591946009225	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
591946009226	type II secretion system protein I; Region: gspI; TIGR01707
591946009227	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
591946009228	Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963
591946009229	Type II transport protein GspH; Region: GspH; pfam12019
591946009230	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
591946009231	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
591946009232	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
591946009233	type II secretion system protein F; Region: GspF; TIGR02120
591946009234	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
591946009235	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
591946009236	type II secretion system protein E; Region: type_II_gspE; TIGR02533
591946009237	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
591946009238	Walker A motif; other site
591946009239	ATP binding site [chemical binding]; other site
591946009240	Walker B motif; other site
591946009241	type II secretion system protein D; Region: type_II_gspD; TIGR02517
591946009242	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
591946009243	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
591946009244	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
591946009245	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
591946009246	putative type II secretion protein GspC; Provisional; Region: PRK09681
591946009247	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
591946009248	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
591946009249	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
591946009250	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
591946009251	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
591946009252	Domain of unknown function (DUF4092); Region: DUF4092; pfam13322
591946009253	Peptidase M60-like family; Region: M60-like; pfam13402
591946009254	glycolate transporter; Provisional; Region: PRK09695
591946009255	L-lactate permease; Region: Lactate_perm; cl00701
591946009256	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
591946009257	active site
591946009258	hypothetical protein; Provisional; Region: PRK09732
591946009259	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
591946009260	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591946009261	Cysteine-rich domain; Region: CCG; pfam02754
591946009262	Cysteine-rich domain; Region: CCG; pfam02754
591946009263	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
591946009264	FAD binding domain; Region: FAD_binding_4; pfam01565
591946009265	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
591946009266	FAD binding domain; Region: FAD_binding_4; pfam01565
591946009267	DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990
591946009268	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946009269	DNA-binding site [nucleotide binding]; DNA binding site
591946009270	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591946009271	acyl-CoA synthetase; Validated; Region: PRK09192
591946009272	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
591946009273	acyl-activating enzyme (AAE) consensus motif; other site
591946009274	active site
591946009275	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
591946009276	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591946009277	NAD(P) binding site [chemical binding]; other site
591946009278	active site
591946009279	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
591946009280	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
591946009281	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
591946009282	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591946009283	catalytic residue [active]
591946009284	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
591946009285	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
591946009286	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
591946009287	Predicted permeases [General function prediction only]; Region: COG0795
591946009288	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695
591946009289	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
591946009290	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
591946009291	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
591946009292	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
591946009293	active site
591946009294	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
591946009295	TMP-binding site; other site
591946009296	ATP-binding site [chemical binding]; other site
591946009297	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
591946009298	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
591946009299	TMP-binding site; other site
591946009300	ATP-binding site [chemical binding]; other site
591946009301	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
591946009302	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
591946009303	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
591946009304	CHAP domain; Region: CHAP; pfam05257
591946009305	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
591946009306	putative S-transferase; Provisional; Region: PRK11752
591946009307	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
591946009308	C-terminal domain interface [polypeptide binding]; other site
591946009309	GSH binding site (G-site) [chemical binding]; other site
591946009310	dimer interface [polypeptide binding]; other site
591946009311	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
591946009312	dimer interface [polypeptide binding]; other site
591946009313	N-terminal domain interface [polypeptide binding]; other site
591946009314	active site
591946009315	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
591946009316	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
591946009317	hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380
591946009318	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
591946009319	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
591946009320	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
591946009321	putative substrate-binding site; other site
591946009322	nickel binding site [ion binding]; other site
591946009323	hydrogenase 2 large subunit; Provisional; Region: PRK10467
591946009324	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
591946009325	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
591946009326	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
591946009327	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
591946009328	4Fe-4S binding domain; Region: Fer4_6; pfam12837
591946009329	hydrogenase 2 small subunit; Provisional; Region: PRK10468
591946009330	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
591946009331	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
591946009332	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
591946009333	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
591946009334	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
591946009335	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591946009336	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591946009337	active site
591946009338	catalytic tetrad [active]
591946009339	hypothetical protein; Provisional; Region: PRK05208
591946009340	oxidoreductase; Provisional; Region: PRK07985
591946009341	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
591946009342	NAD binding site [chemical binding]; other site
591946009343	metal binding site [ion binding]; metal-binding site
591946009344	active site
591946009345	biopolymer transport protein ExbD; Provisional; Region: PRK11267
591946009346	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
591946009347	biopolymer transport protein ExbB; Provisional; Region: PRK10414
591946009348	cystathionine beta-lyase; Provisional; Region: PRK08114
591946009349	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
591946009350	homodimer interface [polypeptide binding]; other site
591946009351	substrate-cofactor binding pocket; other site
591946009352	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946009353	catalytic residue [active]
591946009354	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
591946009355	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
591946009356	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
591946009357	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
591946009358	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946009359	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946009360	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
591946009361	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
591946009362	dimer interface [polypeptide binding]; other site
591946009363	active site
591946009364	metal binding site [ion binding]; metal-binding site
591946009365	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591946009366	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591946009367	active site
591946009368	catalytic tetrad [active]
591946009369	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
591946009370	putative outer membrane lipoprotein; Provisional; Region: PRK09973
591946009371	hypothetical protein; Provisional; Region: PRK01254
591946009372	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
591946009373	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
591946009374	Transcriptional regulators [Transcription]; Region: FadR; COG2186
591946009375	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946009376	DNA-binding site [nucleotide binding]; DNA binding site
591946009377	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591946009378	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
591946009379	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
591946009380	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
591946009381	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591946009382	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
591946009383	putative NAD(P) binding site [chemical binding]; other site
591946009384	catalytic Zn binding site [ion binding]; other site
591946009385	structural Zn binding site [ion binding]; other site
591946009386	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
591946009387	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
591946009388	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
591946009389	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
591946009390	DctM-like transporters; Region: DctM; pfam06808
591946009391	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
591946009392	FtsI repressor; Provisional; Region: PRK10883
591946009393	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
591946009394	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
591946009395	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
591946009396	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
591946009397	putative acyl-acceptor binding pocket; other site
591946009398	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
591946009399	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
591946009400	CAP-like domain; other site
591946009401	active site
591946009402	primary dimer interface [polypeptide binding]; other site
591946009403	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591946009404	putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755
591946009405	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
591946009406	peptide binding site [polypeptide binding]; other site
591946009407	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
591946009408	TIGR00156 family protein; Region: TIGR00156
591946009409	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
591946009410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946009411	active site
591946009412	phosphorylation site [posttranslational modification]
591946009413	intermolecular recognition site; other site
591946009414	dimerization interface [polypeptide binding]; other site
591946009415	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946009416	DNA binding site [nucleotide binding]
591946009417	sensor protein QseC; Provisional; Region: PRK10337
591946009418	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946009419	dimer interface [polypeptide binding]; other site
591946009420	phosphorylation site [posttranslational modification]
591946009421	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946009422	ATP binding site [chemical binding]; other site
591946009423	Mg2+ binding site [ion binding]; other site
591946009424	G-X-G motif; other site
591946009425	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
591946009426	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
591946009427	Uncharacterized conserved protein [Function unknown]; Region: COG1359
591946009428	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
591946009429	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
591946009430	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795
591946009431	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
591946009432	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
591946009433	siderophore binding site; other site
591946009434	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
591946009435	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591946009436	ABC-ATPase subunit  interface; other site
591946009437	dimer interface [polypeptide binding]; other site
591946009438	putative PBP binding regions; other site
591946009439	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
591946009440	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591946009441	dimer interface [polypeptide binding]; other site
591946009442	putative PBP binding regions; other site
591946009443	ABC-ATPase subunit  interface; other site
591946009444	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
591946009445	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
591946009446	Walker A/P-loop; other site
591946009447	ATP binding site [chemical binding]; other site
591946009448	Q-loop/lid; other site
591946009449	ABC transporter signature motif; other site
591946009450	Walker B; other site
591946009451	D-loop; other site
591946009452	H-loop/switch region; other site
591946009453	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
591946009454	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591946009455	N-terminal plug; other site
591946009456	ligand-binding site [chemical binding]; other site
591946009457	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
591946009458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946009459	ATP binding site [chemical binding]; other site
591946009460	Mg2+ binding site [ion binding]; other site
591946009461	G-X-G motif; other site
591946009462	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
591946009463	anchoring element; other site
591946009464	dimer interface [polypeptide binding]; other site
591946009465	ATP binding site [chemical binding]; other site
591946009466	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
591946009467	active site
591946009468	metal binding site [ion binding]; metal-binding site
591946009469	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
591946009470	esterase YqiA; Provisional; Region: PRK11071
591946009471	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
591946009472	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
591946009473	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
591946009474	active site
591946009475	metal binding site [ion binding]; metal-binding site
591946009476	hexamer interface [polypeptide binding]; other site
591946009477	putative dehydrogenase; Provisional; Region: PRK11039
591946009478	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
591946009479	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
591946009480	dimer interface [polypeptide binding]; other site
591946009481	ADP-ribose binding site [chemical binding]; other site
591946009482	active site
591946009483	nudix motif; other site
591946009484	metal binding site [ion binding]; metal-binding site
591946009485	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
591946009486	hypothetical protein; Provisional; Region: PRK11653
591946009487	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
591946009488	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
591946009489	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
591946009490	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
591946009491	catalytic residues [active]
591946009492	hinge region; other site
591946009493	alpha helical domain; other site
591946009494	putative disulfide oxidoreductase; Provisional; Region: PRK04307
591946009495	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
591946009496	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
591946009497	putative active site [active]
591946009498	metal binding site [ion binding]; metal-binding site
591946009499	zinc transporter ZupT; Provisional; Region: PRK04201
591946009500	ZIP Zinc transporter; Region: Zip; pfam02535
591946009501	putative fimbrial protein; Provisional; Region: PRK09733
591946009502	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
591946009503	PapC N-terminal domain; Region: PapC_N; pfam13954
591946009504	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591946009505	PapC C-terminal domain; Region: PapC_C; pfam13953
591946009506	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
591946009507	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591946009508	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591946009509	Fimbrial protein; Region: Fimbrial; pfam00419
591946009510	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
591946009511	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
591946009512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
591946009513	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
591946009514	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
591946009515	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
591946009516	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
591946009517	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
591946009518	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
591946009519	putative ribose interaction site [chemical binding]; other site
591946009520	putative ADP binding site [chemical binding]; other site
591946009521	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
591946009522	active site
591946009523	nucleotide binding site [chemical binding]; other site
591946009524	HIGH motif; other site
591946009525	KMSKS motif; other site
591946009526	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
591946009527	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
591946009528	metal binding triad; other site
591946009529	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
591946009530	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
591946009531	metal binding triad; other site
591946009532	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
591946009533	Uncharacterized conserved protein [Function unknown]; Region: COG3025
591946009534	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
591946009535	putative active site [active]
591946009536	putative metal binding residues [ion binding]; other site
591946009537	signature motif; other site
591946009538	putative triphosphate binding site [ion binding]; other site
591946009539	CHAD domain; Region: CHAD; pfam05235
591946009540	SH3 domain-containing protein; Provisional; Region: PRK10884
591946009541	Bacterial SH3 domain homologues; Region: SH3b; smart00287
591946009542	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
591946009543	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
591946009544	active site
591946009545	NTP binding site [chemical binding]; other site
591946009546	metal binding triad [ion binding]; metal-binding site
591946009547	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
591946009548	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591946009549	Zn2+ binding site [ion binding]; other site
591946009550	Mg2+ binding site [ion binding]; other site
591946009551	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
591946009552	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
591946009553	homooctamer interface [polypeptide binding]; other site
591946009554	active site
591946009555	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
591946009556	transcriptional activator TtdR; Provisional; Region: PRK09801
591946009557	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946009558	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
591946009559	putative effector binding pocket; other site
591946009560	putative dimerization interface [polypeptide binding]; other site
591946009561	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
591946009562	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
591946009563	Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939
591946009564	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
591946009565	transmembrane helices; other site
591946009566	UGMP family protein; Validated; Region: PRK09604
591946009567	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
591946009568	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
591946009569	DNA primase; Validated; Region: dnaG; PRK05667
591946009570	CHC2 zinc finger; Region: zf-CHC2; pfam01807
591946009571	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
591946009572	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
591946009573	active site
591946009574	metal binding site [ion binding]; metal-binding site
591946009575	interdomain interaction site; other site
591946009576	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
591946009577	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
591946009578	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
591946009579	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
591946009580	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
591946009581	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
591946009582	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
591946009583	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
591946009584	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
591946009585	DNA binding residues [nucleotide binding]
591946009586	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
591946009587	active site
591946009588	SUMO-1 interface [polypeptide binding]; other site
591946009589	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
591946009590	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
591946009591	FAD binding pocket [chemical binding]; other site
591946009592	FAD binding motif [chemical binding]; other site
591946009593	phosphate binding motif [ion binding]; other site
591946009594	NAD binding pocket [chemical binding]; other site
591946009595	Predicted transcriptional regulators [Transcription]; Region: COG1695
591946009596	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
591946009597	aerotaxis receptor.
591946009598	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
591946009599	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
591946009600	inhibitor-cofactor binding pocket; inhibition site
591946009601	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946009602	catalytic residue [active]
591946009603	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
591946009604	dimer interface [polypeptide binding]; other site
591946009605	putative tRNA-binding site [nucleotide binding]; other site
591946009606	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
591946009607	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946009608	DNA binding site [nucleotide binding]
591946009609	domain linker motif; other site
591946009610	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
591946009611	putative dimerization interface [polypeptide binding]; other site
591946009612	putative ligand binding site [chemical binding]; other site
591946009613	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
591946009614	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
591946009615	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
591946009616	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
591946009617	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
591946009618	cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202
591946009619	inner membrane transporter YjeM; Provisional; Region: PRK15238
591946009620	alpha-glucosidase; Provisional; Region: PRK10137
591946009621	Protein of unknown function, DUF608; Region: DUF608; pfam04685
591946009622	Trehalase; Region: Trehalase; cl17346
591946009623	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
591946009624	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
591946009625	active site
591946009626	FMN binding site [chemical binding]; other site
591946009627	2,4-decadienoyl-CoA binding site; other site
591946009628	catalytic residue [active]
591946009629	4Fe-4S cluster binding site [ion binding]; other site
591946009630	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
591946009631	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591946009632	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946009633	non-specific DNA binding site [nucleotide binding]; other site
591946009634	salt bridge; other site
591946009635	sequence-specific DNA binding site [nucleotide binding]; other site
591946009636	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
591946009637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946009638	S-adenosylmethionine binding site [chemical binding]; other site
591946009639	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
591946009640	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
591946009641	putative active site [active]
591946009642	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
591946009643	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
591946009644	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
591946009645	serine/threonine transporter SstT; Provisional; Region: PRK13628
591946009646	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
591946009647	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
591946009648	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
591946009649	galactarate dehydratase; Region: galactar-dH20; TIGR03248
591946009650	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
591946009651	Glucuronate isomerase; Region: UxaC; pfam02614
591946009652	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
591946009653	D-galactonate transporter; Region: 2A0114; TIGR00893
591946009654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946009655	putative substrate translocation pore; other site
591946009656	DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523
591946009657	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946009658	DNA-binding site [nucleotide binding]; DNA binding site
591946009659	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591946009660	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
591946009661	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
591946009662	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
591946009663	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
591946009664	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
591946009665	Predicted membrane protein [Function unknown]; Region: COG5393
591946009666	YqjK-like protein; Region: YqjK; pfam13997
591946009667	Predicted membrane protein [Function unknown]; Region: COG2259
591946009668	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
591946009669	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
591946009670	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
591946009671	putative dimer interface [polypeptide binding]; other site
591946009672	N-terminal domain interface [polypeptide binding]; other site
591946009673	putative substrate binding pocket (H-site) [chemical binding]; other site
591946009674	Predicted membrane protein [Function unknown]; Region: COG3152
591946009675	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946009676	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
591946009677	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591946009678	dimerization interface [polypeptide binding]; other site
591946009679	Pirin-related protein [General function prediction only]; Region: COG1741
591946009680	Pirin; Region: Pirin; pfam02678
591946009681	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
591946009682	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
591946009683	serine transporter; Region: stp; TIGR00814
591946009684	L-serine dehydratase TdcG; Provisional; Region: PRK15040
591946009685	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
591946009686	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
591946009687	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
591946009688	homotrimer interaction site [polypeptide binding]; other site
591946009689	putative active site [active]
591946009690	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
591946009691	Pyruvate formate lyase 1; Region: PFL1; cd01678
591946009692	coenzyme A binding site [chemical binding]; other site
591946009693	active site
591946009694	catalytic residues [active]
591946009695	glycine loop; other site
591946009696	propionate/acetate kinase; Provisional; Region: PRK12379
591946009697	Acetokinase family; Region: Acetate_kinase; cl17229
591946009698	threonine/serine transporter TdcC; Provisional; Region: PRK13629
591946009699	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
591946009700	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
591946009701	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
591946009702	tetramer interface [polypeptide binding]; other site
591946009703	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946009704	catalytic residue [active]
591946009705	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
591946009706	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946009707	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
591946009708	putative substrate binding pocket [chemical binding]; other site
591946009709	putative dimerization interface [polypeptide binding]; other site
591946009710	DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424
591946009711	glycerate kinase I; Provisional; Region: PRK10342
591946009712	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
591946009713	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
591946009714	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
591946009715	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946009716	D-galactonate transporter; Region: 2A0114; TIGR00893
591946009717	putative substrate translocation pore; other site
591946009718	galactarate dehydratase; Region: galactar-dH20; TIGR03248
591946009719	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
591946009720	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
591946009721	putative regulator PrlF; Provisional; Region: PRK09974
591946009722	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
591946009723	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
591946009724	DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802
591946009725	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
591946009726	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946009727	tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458
591946009728	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
591946009729	active site
591946009730	phosphorylation site [posttranslational modification]
591946009731	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
591946009732	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
591946009733	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
591946009734	active pocket/dimerization site; other site
591946009735	active site
591946009736	phosphorylation site [posttranslational modification]
591946009737	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
591946009738	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
591946009739	active site
591946009740	dimer interface [polypeptide binding]; other site
591946009741	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
591946009742	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
591946009743	dimer interface [polypeptide binding]; other site
591946009744	active site
591946009745	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
591946009746	putative active site [active]
591946009747	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453
591946009748	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
591946009749	active site
591946009750	intersubunit interface [polypeptide binding]; other site
591946009751	zinc binding site [ion binding]; other site
591946009752	Na+ binding site [ion binding]; other site
591946009753	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
591946009754	active site
591946009755	phosphorylation site [posttranslational modification]
591946009756	PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757
591946009757	PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855
591946009758	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
591946009759	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
591946009760	active site
591946009761	trimer interface [polypeptide binding]; other site
591946009762	allosteric site; other site
591946009763	active site lid [active]
591946009764	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
591946009765	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
591946009766	putative SAM binding site [chemical binding]; other site
591946009767	putative homodimer interface [polypeptide binding]; other site
591946009768	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
591946009769	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
591946009770	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
591946009771	putative ligand binding site [chemical binding]; other site
591946009772	TIGR00252 family protein; Region: TIGR00252
591946009773	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
591946009774	dimer interface [polypeptide binding]; other site
591946009775	active site
591946009776	outer membrane lipoprotein; Provisional; Region: PRK11023
591946009777	BON domain; Region: BON; pfam04972
591946009778	BON domain; Region: BON; pfam04972
591946009779	Predicted permease; Region: DUF318; pfam03773
591946009780	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
591946009781	NADH(P)-binding; Region: NAD_binding_10; pfam13460
591946009782	NAD binding site [chemical binding]; other site
591946009783	active site
591946009784	hypothetical protein; Provisional; Region: PRK03467
591946009785	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
591946009786	GIY-YIG motif/motif A; other site
591946009787	putative active site [active]
591946009788	putative metal binding site [ion binding]; other site
591946009789	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
591946009790	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946009791	Coenzyme A binding pocket [chemical binding]; other site
591946009792	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
591946009793	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
591946009794	Peptidase family U32; Region: Peptidase_U32; pfam01136
591946009795	putative protease; Provisional; Region: PRK15447
591946009796	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
591946009797	hypothetical protein; Provisional; Region: PRK10508
591946009798	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
591946009799	tryptophan permease; Provisional; Region: PRK10483
591946009800	aromatic amino acid transport protein; Region: araaP; TIGR00837
591946009801	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
591946009802	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
591946009803	ATP binding site [chemical binding]; other site
591946009804	Mg++ binding site [ion binding]; other site
591946009805	motif III; other site
591946009806	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591946009807	nucleotide binding region [chemical binding]; other site
591946009808	ATP-binding site [chemical binding]; other site
591946009809	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
591946009810	putative RNA binding site [nucleotide binding]; other site
591946009811	lipoprotein NlpI; Provisional; Region: PRK11189
591946009812	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591946009813	binding surface
591946009814	TPR motif; other site
591946009815	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
591946009816	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
591946009817	RNase E interface [polypeptide binding]; other site
591946009818	trimer interface [polypeptide binding]; other site
591946009819	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
591946009820	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
591946009821	RNase E interface [polypeptide binding]; other site
591946009822	trimer interface [polypeptide binding]; other site
591946009823	active site
591946009824	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
591946009825	putative nucleic acid binding region [nucleotide binding]; other site
591946009826	G-X-X-G motif; other site
591946009827	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
591946009828	RNA binding site [nucleotide binding]; other site
591946009829	domain interface; other site
591946009830	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
591946009831	16S/18S rRNA binding site [nucleotide binding]; other site
591946009832	S13e-L30e interaction site [polypeptide binding]; other site
591946009833	25S rRNA binding site [nucleotide binding]; other site
591946009834	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
591946009835	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
591946009836	RNA binding site [nucleotide binding]; other site
591946009837	active site
591946009838	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
591946009839	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
591946009840	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
591946009841	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
591946009842	translation initiation factor IF-2; Region: IF-2; TIGR00487
591946009843	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
591946009844	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
591946009845	G1 box; other site
591946009846	putative GEF interaction site [polypeptide binding]; other site
591946009847	GTP/Mg2+ binding site [chemical binding]; other site
591946009848	Switch I region; other site
591946009849	G2 box; other site
591946009850	G3 box; other site
591946009851	Switch II region; other site
591946009852	G4 box; other site
591946009853	G5 box; other site
591946009854	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
591946009855	Translation-initiation factor 2; Region: IF-2; pfam11987
591946009856	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
591946009857	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
591946009858	NusA N-terminal domain; Region: NusA_N; pfam08529
591946009859	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
591946009860	RNA binding site [nucleotide binding]; other site
591946009861	homodimer interface [polypeptide binding]; other site
591946009862	NusA-like KH domain; Region: KH_5; pfam13184
591946009863	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
591946009864	G-X-X-G motif; other site
591946009865	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
591946009866	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
591946009867	ribosome maturation protein RimP; Reviewed; Region: PRK00092
591946009868	Sm and related proteins; Region: Sm_like; cl00259
591946009869	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
591946009870	putative oligomer interface [polypeptide binding]; other site
591946009871	putative RNA binding site [nucleotide binding]; other site
591946009872	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
591946009873	ANP binding site [chemical binding]; other site
591946009874	Substrate Binding Site II [chemical binding]; other site
591946009875	Substrate Binding Site I [chemical binding]; other site
591946009876	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
591946009877	Sulfatase; Region: Sulfatase; pfam00884
591946009878	Preprotein translocase SecG subunit; Region: SecG; pfam03840
591946009879	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
591946009880	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
591946009881	active site
591946009882	substrate binding site [chemical binding]; other site
591946009883	metal binding site [ion binding]; metal-binding site
591946009884	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
591946009885	dihydropteroate synthase; Region: DHPS; TIGR01496
591946009886	substrate binding pocket [chemical binding]; other site
591946009887	dimer interface [polypeptide binding]; other site
591946009888	inhibitor binding site; inhibition site
591946009889	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
591946009890	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946009891	Walker A motif; other site
591946009892	ATP binding site [chemical binding]; other site
591946009893	Walker B motif; other site
591946009894	arginine finger; other site
591946009895	Peptidase family M41; Region: Peptidase_M41; pfam01434
591946009896	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
591946009897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946009898	S-adenosylmethionine binding site [chemical binding]; other site
591946009899	RNA-binding protein YhbY; Provisional; Region: PRK10343
591946009900	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
591946009901	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
591946009902	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
591946009903	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
591946009904	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
591946009905	GTPase CgtA; Reviewed; Region: obgE; PRK12298
591946009906	GTP1/OBG; Region: GTP1_OBG; pfam01018
591946009907	Obg GTPase; Region: Obg; cd01898
591946009908	G1 box; other site
591946009909	GTP/Mg2+ binding site [chemical binding]; other site
591946009910	Switch I region; other site
591946009911	G2 box; other site
591946009912	G3 box; other site
591946009913	Switch II region; other site
591946009914	G4 box; other site
591946009915	G5 box; other site
591946009916	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
591946009917	EamA-like transporter family; Region: EamA; pfam00892
591946009918	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
591946009919	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
591946009920	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
591946009921	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
591946009922	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
591946009923	substrate binding pocket [chemical binding]; other site
591946009924	chain length determination region; other site
591946009925	substrate-Mg2+ binding site; other site
591946009926	catalytic residues [active]
591946009927	aspartate-rich region 1; other site
591946009928	active site lid residues [active]
591946009929	aspartate-rich region 2; other site
591946009930	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
591946009931	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
591946009932	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
591946009933	hinge; other site
591946009934	active site
591946009935	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
591946009936	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
591946009937	anti sigma factor interaction site; other site
591946009938	regulatory phosphorylation site [posttranslational modification]; other site
591946009939	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
591946009940	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
591946009941	mce related protein; Region: MCE; pfam02470
591946009942	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
591946009943	conserved hypothetical integral membrane protein; Region: TIGR00056
591946009944	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
591946009945	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
591946009946	Walker A/P-loop; other site
591946009947	ATP binding site [chemical binding]; other site
591946009948	Q-loop/lid; other site
591946009949	ABC transporter signature motif; other site
591946009950	Walker B; other site
591946009951	D-loop; other site
591946009952	H-loop/switch region; other site
591946009953	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
591946009954	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
591946009955	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
591946009956	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
591946009957	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
591946009958	putative active site [active]
591946009959	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
591946009960	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
591946009961	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
591946009962	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
591946009963	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
591946009964	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
591946009965	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
591946009966	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
591946009967	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
591946009968	Walker A/P-loop; other site
591946009969	ATP binding site [chemical binding]; other site
591946009970	Q-loop/lid; other site
591946009971	ABC transporter signature motif; other site
591946009972	Walker B; other site
591946009973	D-loop; other site
591946009974	H-loop/switch region; other site
591946009975	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
591946009976	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
591946009977	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
591946009978	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
591946009979	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
591946009980	30S subunit binding site; other site
591946009981	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591946009982	active site
591946009983	phosphorylation site [posttranslational modification]
591946009984	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
591946009985	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
591946009986	dimerization domain swap beta strand [polypeptide binding]; other site
591946009987	regulatory protein interface [polypeptide binding]; other site
591946009988	active site
591946009989	regulatory phosphorylation site [posttranslational modification]; other site
591946009990	hypothetical protein; Provisional; Region: PRK10345
591946009991	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
591946009992	Transglycosylase; Region: Transgly; cl17702
591946009993	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
591946009994	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
591946009995	conserved cys residue [active]
591946009996	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
591946009997	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591946009998	putative active site [active]
591946009999	heme pocket [chemical binding]; other site
591946010000	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946010001	dimer interface [polypeptide binding]; other site
591946010002	phosphorylation site [posttranslational modification]
591946010003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946010004	ATP binding site [chemical binding]; other site
591946010005	Mg2+ binding site [ion binding]; other site
591946010006	G-X-G motif; other site
591946010007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946010008	active site
591946010009	phosphorylation site [posttranslational modification]
591946010010	intermolecular recognition site; other site
591946010011	dimerization interface [polypeptide binding]; other site
591946010012	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
591946010013	putative binding surface; other site
591946010014	active site
591946010015	radical SAM protein, TIGR01212 family; Region: TIGR01212
591946010016	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946010017	FeS/SAM binding site; other site
591946010018	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
591946010019	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
591946010020	active site
591946010021	dimer interface [polypeptide binding]; other site
591946010022	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
591946010023	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
591946010024	active site
591946010025	FMN binding site [chemical binding]; other site
591946010026	substrate binding site [chemical binding]; other site
591946010027	3Fe-4S cluster binding site [ion binding]; other site
591946010028	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
591946010029	domain interface; other site
591946010030	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
591946010031	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591946010032	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946010033	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
591946010034	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
591946010035	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
591946010036	N-acetylmannosamine kinase; Provisional; Region: PRK05082
591946010037	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591946010038	nucleotide binding site [chemical binding]; other site
591946010039	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
591946010040	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
591946010041	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
591946010042	putative active site cavity [active]
591946010043	putative sialic acid transporter; Provisional; Region: PRK03893
591946010044	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946010045	putative substrate translocation pore; other site
591946010046	N-acetylneuraminate lyase; Region: nanA; TIGR00683
591946010047	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
591946010048	inhibitor site; inhibition site
591946010049	active site
591946010050	dimer interface [polypeptide binding]; other site
591946010051	catalytic residue [active]
591946010052	transcriptional regulator NanR; Provisional; Region: PRK03837
591946010053	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946010054	DNA-binding site [nucleotide binding]; DNA binding site
591946010055	FCD domain; Region: FCD; pfam07729
591946010056	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
591946010057	stringent starvation protein A; Provisional; Region: sspA; PRK09481
591946010058	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
591946010059	C-terminal domain interface [polypeptide binding]; other site
591946010060	putative GSH binding site (G-site) [chemical binding]; other site
591946010061	dimer interface [polypeptide binding]; other site
591946010062	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
591946010063	dimer interface [polypeptide binding]; other site
591946010064	N-terminal domain interface [polypeptide binding]; other site
591946010065	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
591946010066	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
591946010067	23S rRNA interface [nucleotide binding]; other site
591946010068	L3 interface [polypeptide binding]; other site
591946010069	Predicted ATPase [General function prediction only]; Region: COG1485
591946010070	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
591946010071	hypothetical protein; Provisional; Region: PRK11677
591946010072	serine endoprotease; Provisional; Region: PRK10139
591946010073	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
591946010074	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
591946010075	protein binding site [polypeptide binding]; other site
591946010076	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
591946010077	serine endoprotease; Provisional; Region: PRK10898
591946010078	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
591946010079	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
591946010080	malate dehydrogenase; Provisional; Region: PRK05086
591946010081	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
591946010082	NAD binding site [chemical binding]; other site
591946010083	dimerization interface [polypeptide binding]; other site
591946010084	Substrate binding site [chemical binding]; other site
591946010085	arginine repressor; Provisional; Region: PRK05066
591946010086	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
591946010087	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
591946010088	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591946010089	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
591946010090	RNAase interaction site [polypeptide binding]; other site
591946010091	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
591946010092	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
591946010093	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
591946010094	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946010095	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946010096	efflux system membrane protein; Provisional; Region: PRK11594
591946010097	transcriptional regulator; Provisional; Region: PRK10632
591946010098	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946010099	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
591946010100	putative effector binding pocket; other site
591946010101	dimerization interface [polypeptide binding]; other site
591946010102	protease TldD; Provisional; Region: tldD; PRK10735
591946010103	hypothetical protein; Provisional; Region: PRK10899
591946010104	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
591946010105	ribonuclease G; Provisional; Region: PRK11712
591946010106	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
591946010107	homodimer interface [polypeptide binding]; other site
591946010108	oligonucleotide binding site [chemical binding]; other site
591946010109	Maf-like protein; Region: Maf; pfam02545
591946010110	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
591946010111	active site
591946010112	dimer interface [polypeptide binding]; other site
591946010113	rod shape-determining protein MreD; Provisional; Region: PRK11060
591946010114	rod shape-determining protein MreC; Region: mreC; TIGR00219
591946010115	rod shape-determining protein MreC; Region: MreC; pfam04085
591946010116	rod shape-determining protein MreB; Provisional; Region: PRK13927
591946010117	MreB and similar proteins; Region: MreB_like; cd10225
591946010118	nucleotide binding site [chemical binding]; other site
591946010119	Mg binding site [ion binding]; other site
591946010120	putative protofilament interaction site [polypeptide binding]; other site
591946010121	RodZ interaction site [polypeptide binding]; other site
591946010122	regulatory protein CsrD; Provisional; Region: PRK11059
591946010123	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946010124	metal binding site [ion binding]; metal-binding site
591946010125	active site
591946010126	I-site; other site
591946010127	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946010128	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
591946010129	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
591946010130	NADP binding site [chemical binding]; other site
591946010131	dimer interface [polypeptide binding]; other site
591946010132	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
591946010133	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
591946010134	carboxyltransferase (CT) interaction site; other site
591946010135	biotinylation site [posttranslational modification]; other site
591946010136	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
591946010137	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
591946010138	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
591946010139	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
591946010140	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
591946010141	active site
591946010142	catalytic residues [active]
591946010143	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591946010144	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
591946010145	substrate binding site [chemical binding]; other site
591946010146	ATP binding site [chemical binding]; other site
591946010147	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591946010148	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591946010149	TM-ABC transporter signature motif; other site
591946010150	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
591946010151	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591946010152	Walker A/P-loop; other site
591946010153	ATP binding site [chemical binding]; other site
591946010154	Q-loop/lid; other site
591946010155	ABC transporter signature motif; other site
591946010156	Walker B; other site
591946010157	D-loop; other site
591946010158	H-loop/switch region; other site
591946010159	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591946010160	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
591946010161	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322
591946010162	putative ligand binding site [chemical binding]; other site
591946010163	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
591946010164	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
591946010165	intersubunit interface [polypeptide binding]; other site
591946010166	active site
591946010167	zinc binding site [ion binding]; other site
591946010168	Na+ binding site [ion binding]; other site
591946010169	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591946010170	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
591946010171	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946010172	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591946010173	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
591946010174	substrate binding site [chemical binding]; other site
591946010175	ATP binding site [chemical binding]; other site
591946010176	hypothetical protein; Provisional; Region: PRK10633
591946010177	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
591946010178	Na binding site [ion binding]; other site
591946010179	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
591946010180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
591946010181	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
591946010182	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
591946010183	FMN binding site [chemical binding]; other site
591946010184	active site
591946010185	catalytic residues [active]
591946010186	substrate binding site [chemical binding]; other site
591946010187	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
591946010188	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
591946010189	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
591946010190	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946010191	DNA methylase; Region: N6_N4_Mtase; pfam01555
591946010192	Protein of unknown function (DUF2556); Region: DUF2556; pfam10831
591946010193	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
591946010194	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591946010195	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
591946010196	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
591946010197	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946010198	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946010199	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
591946010200	Protein export membrane protein; Region: SecD_SecF; cl14618
591946010201	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
591946010202	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
591946010203	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946010204	substrate binding pocket [chemical binding]; other site
591946010205	membrane-bound complex binding site; other site
591946010206	hinge residues; other site
591946010207	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
591946010208	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946010209	conserved gate region; other site
591946010210	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946010211	dimer interface [polypeptide binding]; other site
591946010212	conserved gate region; other site
591946010213	putative PBP binding loops; other site
591946010214	ABC-ATPase subunit interface; other site
591946010215	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591946010216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946010217	dimer interface [polypeptide binding]; other site
591946010218	conserved gate region; other site
591946010219	putative PBP binding loops; other site
591946010220	ABC-ATPase subunit interface; other site
591946010221	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
591946010222	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
591946010223	Walker A/P-loop; other site
591946010224	ATP binding site [chemical binding]; other site
591946010225	Q-loop/lid; other site
591946010226	ABC transporter signature motif; other site
591946010227	Walker B; other site
591946010228	D-loop; other site
591946010229	H-loop/switch region; other site
591946010230	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
591946010231	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
591946010232	trimer interface [polypeptide binding]; other site
591946010233	putative metal binding site [ion binding]; other site
591946010234	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
591946010235	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
591946010236	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
591946010237	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
591946010238	shikimate binding site; other site
591946010239	NAD(P) binding site [chemical binding]; other site
591946010240	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
591946010241	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
591946010242	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
591946010243	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
591946010244	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
591946010245	hypothetical protein; Validated; Region: PRK03430
591946010246	hypothetical protein; Provisional; Region: PRK10736
591946010247	DNA protecting protein DprA; Region: dprA; TIGR00732
591946010248	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
591946010249	active site
591946010250	catalytic residues [active]
591946010251	metal binding site [ion binding]; metal-binding site
591946010252	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
591946010253	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
591946010254	putative active site [active]
591946010255	substrate binding site [chemical binding]; other site
591946010256	putative cosubstrate binding site; other site
591946010257	catalytic site [active]
591946010258	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
591946010259	substrate binding site [chemical binding]; other site
591946010260	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
591946010261	putative RNA binding site [nucleotide binding]; other site
591946010262	16S rRNA methyltransferase B; Provisional; Region: PRK10901
591946010263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946010264	S-adenosylmethionine binding site [chemical binding]; other site
591946010265	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
591946010266	TrkA-N domain; Region: TrkA_N; pfam02254
591946010267	TrkA-C domain; Region: TrkA_C; pfam02080
591946010268	TrkA-N domain; Region: TrkA_N; pfam02254
591946010269	TrkA-C domain; Region: TrkA_C; pfam02080
591946010270	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
591946010271	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
591946010272	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
591946010273	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
591946010274	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
591946010275	DNA binding residues [nucleotide binding]
591946010276	dimer interface [polypeptide binding]; other site
591946010277	metal binding site [ion binding]; metal-binding site
591946010278	hypothetical protein; Provisional; Region: PRK10203
591946010279	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
591946010280	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
591946010281	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
591946010282	alphaNTD homodimer interface [polypeptide binding]; other site
591946010283	alphaNTD - beta interaction site [polypeptide binding]; other site
591946010284	alphaNTD - beta' interaction site [polypeptide binding]; other site
591946010285	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
591946010286	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
591946010287	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
591946010288	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591946010289	RNA binding surface [nucleotide binding]; other site
591946010290	30S ribosomal protein S11; Validated; Region: PRK05309
591946010291	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
591946010292	30S ribosomal protein S13; Region: bact_S13; TIGR03631
591946010293	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
591946010294	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
591946010295	SecY translocase; Region: SecY; pfam00344
591946010296	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
591946010297	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
591946010298	23S rRNA binding site [nucleotide binding]; other site
591946010299	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
591946010300	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
591946010301	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
591946010302	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
591946010303	23S rRNA interface [nucleotide binding]; other site
591946010304	5S rRNA interface [nucleotide binding]; other site
591946010305	L27 interface [polypeptide binding]; other site
591946010306	L5 interface [polypeptide binding]; other site
591946010307	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
591946010308	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
591946010309	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
591946010310	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
591946010311	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
591946010312	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
591946010313	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
591946010314	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
591946010315	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
591946010316	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
591946010317	RNA binding site [nucleotide binding]; other site
591946010318	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
591946010319	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
591946010320	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
591946010321	23S rRNA interface [nucleotide binding]; other site
591946010322	putative translocon interaction site; other site
591946010323	signal recognition particle (SRP54) interaction site; other site
591946010324	L23 interface [polypeptide binding]; other site
591946010325	trigger factor interaction site; other site
591946010326	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
591946010327	23S rRNA interface [nucleotide binding]; other site
591946010328	5S rRNA interface [nucleotide binding]; other site
591946010329	putative antibiotic binding site [chemical binding]; other site
591946010330	L25 interface [polypeptide binding]; other site
591946010331	L27 interface [polypeptide binding]; other site
591946010332	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
591946010333	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
591946010334	G-X-X-G motif; other site
591946010335	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
591946010336	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
591946010337	protein-rRNA interface [nucleotide binding]; other site
591946010338	putative translocon binding site; other site
591946010339	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
591946010340	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
591946010341	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
591946010342	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
591946010343	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
591946010344	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
591946010345	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
591946010346	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
591946010347	protein secretion protein GspB; Provisional; Region: PRK09697
591946010348	AAA domain; Region: AAA_22; pfam13401
591946010349	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
591946010350	Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031
591946010351	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
591946010352	type II secretion system protein D; Region: type_II_gspD; TIGR02517
591946010353	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
591946010354	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
591946010355	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
591946010356	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
591946010357	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
591946010358	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
591946010359	Walker A motif; other site
591946010360	ATP binding site [chemical binding]; other site
591946010361	Walker B motif; other site
591946010362	type II secretion system protein F; Region: GspF; TIGR02120
591946010363	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
591946010364	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
591946010365	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
591946010366	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
591946010367	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
591946010368	Type II transport protein GspH; Region: GspH; pfam12019
591946010369	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
591946010370	type II secretion system protein I; Region: gspI; TIGR01707
591946010371	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
591946010372	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
591946010373	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
591946010374	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
591946010375	Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156
591946010376	Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297
591946010377	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
591946010378	GspL periplasmic domain; Region: GspL_C; pfam12693
591946010379	general secretion pathway protein M
591946010380	Type 4 prepilin-like proteins leader peptide-processing
591946010381	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
591946010382	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
591946010383	heme binding site [chemical binding]; other site
591946010384	ferroxidase pore; other site
591946010385	ferroxidase diiron center [ion binding]; other site
591946010386	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
591946010387	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
591946010388	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
591946010389	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
591946010390	aromatic chitin/cellulose binding site residues [chemical binding]; other site
591946010391	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
591946010392	active site
591946010393	elongation factor Tu; Reviewed; Region: PRK00049
591946010394	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
591946010395	G1 box; other site
591946010396	GEF interaction site [polypeptide binding]; other site
591946010397	GTP/Mg2+ binding site [chemical binding]; other site
591946010398	Switch I region; other site
591946010399	G2 box; other site
591946010400	G3 box; other site
591946010401	Switch II region; other site
591946010402	G4 box; other site
591946010403	G5 box; other site
591946010404	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
591946010405	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
591946010406	Antibiotic Binding Site [chemical binding]; other site
591946010407	elongation factor G; Reviewed; Region: PRK00007
591946010408	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
591946010409	G1 box; other site
591946010410	putative GEF interaction site [polypeptide binding]; other site
591946010411	GTP/Mg2+ binding site [chemical binding]; other site
591946010412	Switch I region; other site
591946010413	G2 box; other site
591946010414	G3 box; other site
591946010415	Switch II region; other site
591946010416	G4 box; other site
591946010417	G5 box; other site
591946010418	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
591946010419	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
591946010420	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
591946010421	30S ribosomal protein S7; Validated; Region: PRK05302
591946010422	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
591946010423	S17 interaction site [polypeptide binding]; other site
591946010424	S8 interaction site; other site
591946010425	16S rRNA interaction site [nucleotide binding]; other site
591946010426	streptomycin interaction site [chemical binding]; other site
591946010427	23S rRNA interaction site [nucleotide binding]; other site
591946010428	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
591946010429	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
591946010430	sulfur relay protein TusC; Validated; Region: PRK00211
591946010431	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
591946010432	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
591946010433	YheO-like PAS domain; Region: PAS_6; pfam08348
591946010434	HTH domain; Region: HTH_22; pfam13309
591946010435	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
591946010436	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
591946010437	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
591946010438	phi X174 lysis protein; Provisional; Region: PRK02793
591946010439	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
591946010440	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
591946010441	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
591946010442	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
591946010443	TrkA-N domain; Region: TrkA_N; pfam02254
591946010444	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
591946010445	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
591946010446	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946010447	Walker A/P-loop; other site
591946010448	ATP binding site [chemical binding]; other site
591946010449	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591946010450	ABC transporter signature motif; other site
591946010451	Walker B; other site
591946010452	D-loop; other site
591946010453	ABC transporter; Region: ABC_tran_2; pfam12848
591946010454	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591946010455	putative hydrolase; Provisional; Region: PRK10985
591946010456	hypothetical protein; Provisional; Region: PRK04966
591946010457	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
591946010458	active site
591946010459	hypothetical protein; Provisional; Region: PRK10738
591946010460	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
591946010461	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
591946010462	ligand binding site [chemical binding]; other site
591946010463	flexible hinge region; other site
591946010464	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
591946010465	putative switch regulator; other site
591946010466	non-specific DNA interactions [nucleotide binding]; other site
591946010467	DNA binding site [nucleotide binding]
591946010468	sequence specific DNA binding site [nucleotide binding]; other site
591946010469	putative cAMP binding site [chemical binding]; other site
591946010470	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
591946010471	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
591946010472	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
591946010473	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
591946010474	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
591946010475	inhibitor-cofactor binding pocket; inhibition site
591946010476	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946010477	catalytic residue [active]
591946010478	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
591946010479	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
591946010480	glutamine binding [chemical binding]; other site
591946010481	catalytic triad [active]
591946010482	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
591946010483	cell filamentation protein Fic; Provisional; Region: PRK10347
591946010484	hypothetical protein; Provisional; Region: PRK10204
591946010485	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
591946010486	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
591946010487	substrate binding site [chemical binding]; other site
591946010488	putative transporter; Provisional; Region: PRK03699
591946010489	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946010490	putative substrate translocation pore; other site
591946010491	nitrite reductase subunit NirD; Provisional; Region: PRK14989
591946010492	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946010493	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
591946010494	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
591946010495	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
591946010496	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
591946010497	nitrite transporter NirC; Provisional; Region: PRK11562
591946010498	siroheme synthase; Provisional; Region: cysG; PRK10637
591946010499	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
591946010500	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
591946010501	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
591946010502	active site
591946010503	SAM binding site [chemical binding]; other site
591946010504	homodimer interface [polypeptide binding]; other site
591946010505	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
591946010506	DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056
591946010507	Protein of unknown function; Region: YhfT; pfam10797
591946010508	Protein of unknown function DUF2620; Region: DUF2620; pfam10941
591946010509	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
591946010510	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
591946010511	active site
591946010512	substrate binding pocket [chemical binding]; other site
591946010513	homodimer interaction site [polypeptide binding]; other site
591946010514	putative mutase; Provisional; Region: PRK12383
591946010515	Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015
591946010516	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811
591946010517	dimer interface [polypeptide binding]; other site
591946010518	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
591946010519	active site
591946010520	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591946010521	substrate binding site [chemical binding]; other site
591946010522	catalytic residue [active]
591946010523	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
591946010524	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
591946010525	active site
591946010526	HIGH motif; other site
591946010527	dimer interface [polypeptide binding]; other site
591946010528	KMSKS motif; other site
591946010529	phosphoglycolate phosphatase; Provisional; Region: PRK13222
591946010530	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946010531	motif II; other site
591946010532	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
591946010533	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
591946010534	substrate binding site [chemical binding]; other site
591946010535	hexamer interface [polypeptide binding]; other site
591946010536	metal binding site [ion binding]; metal-binding site
591946010537	DNA adenine methylase; Provisional; Region: PRK10904
591946010538	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266
591946010539	cell division protein DamX; Validated; Region: PRK10905
591946010540	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
591946010541	active site
591946010542	dimer interface [polypeptide binding]; other site
591946010543	metal binding site [ion binding]; metal-binding site
591946010544	shikimate kinase; Reviewed; Region: aroK; PRK00131
591946010545	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
591946010546	ADP binding site [chemical binding]; other site
591946010547	magnesium binding site [ion binding]; other site
591946010548	putative shikimate binding site; other site
591946010549	outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560
591946010550	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
591946010551	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
591946010552	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
591946010553	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
591946010554	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
591946010555	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
591946010556	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
591946010557	Transglycosylase; Region: Transgly; pfam00912
591946010558	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
591946010559	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
591946010560	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
591946010561	ADP-ribose binding site [chemical binding]; other site
591946010562	dimer interface [polypeptide binding]; other site
591946010563	active site
591946010564	nudix motif; other site
591946010565	metal binding site [ion binding]; metal-binding site
591946010566	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
591946010567	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
591946010568	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946010569	motif II; other site
591946010570	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591946010571	RNA binding surface [nucleotide binding]; other site
591946010572	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
591946010573	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
591946010574	dimerization interface [polypeptide binding]; other site
591946010575	domain crossover interface; other site
591946010576	redox-dependent activation switch; other site
591946010577	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
591946010578	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
591946010579	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
591946010580	active site
591946010581	substrate-binding site [chemical binding]; other site
591946010582	metal-binding site [ion binding]
591946010583	ATP binding site [chemical binding]; other site
591946010584	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
591946010585	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591946010586	dimerization interface [polypeptide binding]; other site
591946010587	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946010588	dimer interface [polypeptide binding]; other site
591946010589	phosphorylation site [posttranslational modification]
591946010590	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946010591	ATP binding site [chemical binding]; other site
591946010592	G-X-G motif; other site
591946010593	osmolarity response regulator; Provisional; Region: ompR; PRK09468
591946010594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946010595	active site
591946010596	phosphorylation site [posttranslational modification]
591946010597	intermolecular recognition site; other site
591946010598	dimerization interface [polypeptide binding]; other site
591946010599	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946010600	DNA binding site [nucleotide binding]
591946010601	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
591946010602	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
591946010603	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
591946010604	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
591946010605	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
591946010606	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
591946010607	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
591946010608	RNA binding site [nucleotide binding]; other site
591946010609	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
591946010610	Nucleoside recognition; Region: Gate; pfam07670
591946010611	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
591946010612	Nucleoside recognition; Region: Gate; pfam07670
591946010613	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
591946010614	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
591946010615	carboxylesterase BioH; Provisional; Region: PRK10349
591946010616	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
591946010617	DNA utilization protein GntX; Provisional; Region: PRK11595
591946010618	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591946010619	active site
591946010620	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
591946010621	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
591946010622	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
591946010623	high-affinity gluconate transporter; Provisional; Region: PRK14984
591946010624	gluconate transporter; Region: gntP; TIGR00791
591946010625	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
591946010626	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
591946010627	maltodextrin phosphorylase; Provisional; Region: PRK14985
591946010628	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
591946010629	homodimer interface [polypeptide binding]; other site
591946010630	active site pocket [active]
591946010631	transcriptional regulator MalT; Provisional; Region: PRK04841
591946010632	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946010633	DNA binding residues [nucleotide binding]
591946010634	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
591946010635	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
591946010636	putative active site [active]
591946010637	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
591946010638	hypothetical protein; Reviewed; Region: PRK09588
591946010639	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
591946010640	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
591946010641	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946010642	Walker A motif; other site
591946010643	ATP binding site [chemical binding]; other site
591946010644	Walker B motif; other site
591946010645	arginine finger; other site
591946010646	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
591946010647	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
591946010648	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946010649	intramembrane serine protease GlpG; Provisional; Region: PRK10907
591946010650	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
591946010651	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
591946010652	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
591946010653	active site residue [active]
591946010654	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
591946010655	hypothetical protein; Provisional; Region: PRK09781; cl08057
591946010656	Fimbrial protein; Region: Fimbrial; cl01416
591946010657	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
591946010658	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591946010659	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591946010660	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591946010661	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591946010662	outer membrane usher protein; Provisional; Region: PRK15193
591946010663	PapC N-terminal domain; Region: PapC_N; pfam13954
591946010664	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591946010665	PapC C-terminal domain; Region: PapC_C; pfam13953
591946010666	fimbrial chaperone protein StiB; Provisional; Region: PRK15299
591946010667	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591946010668	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591946010669	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591946010670	glycogen phosphorylase; Provisional; Region: PRK14986
591946010671	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
591946010672	homodimer interface [polypeptide binding]; other site
591946010673	active site pocket [active]
591946010674	glycogen synthase; Provisional; Region: glgA; PRK00654
591946010675	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
591946010676	ADP-binding pocket [chemical binding]; other site
591946010677	homodimer interface [polypeptide binding]; other site
591946010678	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
591946010679	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
591946010680	ligand binding site; other site
591946010681	oligomer interface; other site
591946010682	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
591946010683	sulfate 1 binding site; other site
591946010684	glycogen debranching enzyme; Provisional; Region: PRK03705
591946010685	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
591946010686	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
591946010687	active site
591946010688	catalytic site [active]
591946010689	glycogen branching enzyme; Provisional; Region: PRK05402
591946010690	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
591946010691	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
591946010692	active site
591946010693	catalytic site [active]
591946010694	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
591946010695	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
591946010696	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
591946010697	putative antibiotic transporter; Provisional; Region: PRK10739
591946010698	low affinity gluconate transporter; Provisional; Region: PRK10472
591946010699	gluconate transporter; Region: gntP; TIGR00791
591946010700	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
591946010701	Shikimate kinase; Region: SKI; pfam01202
591946010702	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
591946010703	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946010704	DNA binding site [nucleotide binding]
591946010705	domain linker motif; other site
591946010706	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
591946010707	putative ligand binding site [chemical binding]; other site
591946010708	putative dimerization interface [polypeptide binding]; other site
591946010709	Pirin-related protein [General function prediction only]; Region: COG1741
591946010710	Pirin; Region: Pirin; pfam02678
591946010711	putative oxidoreductase; Provisional; Region: PRK10206
591946010712	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
591946010713	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
591946010714	putative acetyltransferase YhhY; Provisional; Region: PRK10140
591946010715	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946010716	Coenzyme A binding pocket [chemical binding]; other site
591946010717	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
591946010718	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
591946010719	YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849
591946010720	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
591946010721	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
591946010722	hypothetical protein; Provisional; Region: PRK10350
591946010723	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
591946010724	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
591946010725	putative active site [active]
591946010726	catalytic site [active]
591946010727	putative metal binding site [ion binding]; other site
591946010728	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
591946010729	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
591946010730	Walker A/P-loop; other site
591946010731	ATP binding site [chemical binding]; other site
591946010732	Q-loop/lid; other site
591946010733	ABC transporter signature motif; other site
591946010734	Walker B; other site
591946010735	D-loop; other site
591946010736	H-loop/switch region; other site
591946010737	TOBE domain; Region: TOBE_2; pfam08402
591946010738	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
591946010739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946010740	dimer interface [polypeptide binding]; other site
591946010741	conserved gate region; other site
591946010742	putative PBP binding loops; other site
591946010743	ABC-ATPase subunit interface; other site
591946010744	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
591946010745	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946010746	dimer interface [polypeptide binding]; other site
591946010747	conserved gate region; other site
591946010748	putative PBP binding loops; other site
591946010749	ABC-ATPase subunit interface; other site
591946010750	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
591946010751	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
591946010752	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
591946010753	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
591946010754	Walker A/P-loop; other site
591946010755	ATP binding site [chemical binding]; other site
591946010756	Q-loop/lid; other site
591946010757	ABC transporter signature motif; other site
591946010758	Walker B; other site
591946010759	D-loop; other site
591946010760	H-loop/switch region; other site
591946010761	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
591946010762	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
591946010763	Walker A/P-loop; other site
591946010764	ATP binding site [chemical binding]; other site
591946010765	Q-loop/lid; other site
591946010766	ABC transporter signature motif; other site
591946010767	Walker B; other site
591946010768	D-loop; other site
591946010769	H-loop/switch region; other site
591946010770	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
591946010771	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
591946010772	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
591946010773	TM-ABC transporter signature motif; other site
591946010774	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591946010775	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
591946010776	TM-ABC transporter signature motif; other site
591946010777	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
591946010778	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
591946010779	dimerization interface [polypeptide binding]; other site
591946010780	ligand binding site [chemical binding]; other site
591946010781	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
591946010782	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
591946010783	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
591946010784	dimerization interface [polypeptide binding]; other site
591946010785	ligand binding site [chemical binding]; other site
591946010786	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
591946010787	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
591946010788	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
591946010789	DNA binding residues [nucleotide binding]
591946010790	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
591946010791	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
591946010792	cell division protein FtsE; Provisional; Region: PRK10908
591946010793	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946010794	Walker A/P-loop; other site
591946010795	ATP binding site [chemical binding]; other site
591946010796	Q-loop/lid; other site
591946010797	ABC transporter signature motif; other site
591946010798	Walker B; other site
591946010799	D-loop; other site
591946010800	H-loop/switch region; other site
591946010801	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
591946010802	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
591946010803	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
591946010804	P loop; other site
591946010805	GTP binding site [chemical binding]; other site
591946010806	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
591946010807	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946010808	S-adenosylmethionine binding site [chemical binding]; other site
591946010809	hypothetical protein; Provisional; Region: PRK10910
591946010810	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
591946010811	Predicted membrane protein [Function unknown]; Region: COG3714
591946010812	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
591946010813	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
591946010814	metal-binding site [ion binding]
591946010815	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591946010816	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
591946010817	CPxP  motif; other site
591946010818	hypothetical protein; Provisional; Region: PRK11212
591946010819	hypothetical protein; Provisional; Region: PRK11615
591946010820	major facilitator superfamily transporter; Provisional; Region: PRK05122
591946010821	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946010822	putative substrate translocation pore; other site
591946010823	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
591946010824	Domain of unknown function DUF20; Region: UPF0118; pfam01594
591946010825	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
591946010826	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
591946010827	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
591946010828	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
591946010829	substrate binding site [chemical binding]; other site
591946010830	nickel transporter permease NikB; Provisional; Region: PRK10352
591946010831	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946010832	dimer interface [polypeptide binding]; other site
591946010833	conserved gate region; other site
591946010834	putative PBP binding loops; other site
591946010835	ABC-ATPase subunit interface; other site
591946010836	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
591946010837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946010838	dimer interface [polypeptide binding]; other site
591946010839	conserved gate region; other site
591946010840	putative PBP binding loops; other site
591946010841	ABC-ATPase subunit interface; other site
591946010842	nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418
591946010843	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946010844	Walker A/P-loop; other site
591946010845	ATP binding site [chemical binding]; other site
591946010846	Q-loop/lid; other site
591946010847	ABC transporter signature motif; other site
591946010848	Walker B; other site
591946010849	D-loop; other site
591946010850	H-loop/switch region; other site
591946010851	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
591946010852	nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419
591946010853	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946010854	Walker A/P-loop; other site
591946010855	ATP binding site [chemical binding]; other site
591946010856	Q-loop/lid; other site
591946010857	ABC transporter signature motif; other site
591946010858	Walker B; other site
591946010859	D-loop; other site
591946010860	H-loop/switch region; other site
591946010861	nickel responsive regulator; Provisional; Region: PRK02967
591946010862	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
591946010863	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
591946010864	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946010865	DNA-binding site [nucleotide binding]; DNA binding site
591946010866	UTRA domain; Region: UTRA; pfam07702
591946010867	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591946010868	active site
591946010869	phosphorylation site [posttranslational modification]
591946010870	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
591946010871	active site
591946010872	P-loop; other site
591946010873	phosphorylation site [posttranslational modification]
591946010874	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
591946010875	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
591946010876	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
591946010877	uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774
591946010878	putative N- and C-terminal domain interface [polypeptide binding]; other site
591946010879	putative active site [active]
591946010880	putative MgATP binding site [chemical binding]; other site
591946010881	catalytic site [active]
591946010882	metal binding site [ion binding]; metal-binding site
591946010883	putative carbohydrate binding site [chemical binding]; other site
591946010884	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
591946010885	dimerization domain swap beta strand [polypeptide binding]; other site
591946010886	regulatory protein interface [polypeptide binding]; other site
591946010887	active site
591946010888	regulatory phosphorylation site [posttranslational modification]; other site
591946010889	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
591946010890	intersubunit interface [polypeptide binding]; other site
591946010891	active site
591946010892	zinc binding site [ion binding]; other site
591946010893	Na+ binding site [ion binding]; other site
591946010894	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
591946010895	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
591946010896	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591946010897	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
591946010898	Walker A/P-loop; other site
591946010899	ATP binding site [chemical binding]; other site
591946010900	Q-loop/lid; other site
591946010901	ABC transporter signature motif; other site
591946010902	Walker B; other site
591946010903	D-loop; other site
591946010904	H-loop/switch region; other site
591946010905	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591946010906	Walker A/P-loop; other site
591946010907	ATP binding site [chemical binding]; other site
591946010908	Q-loop/lid; other site
591946010909	ABC transporter signature motif; other site
591946010910	Walker B; other site
591946010911	D-loop; other site
591946010912	H-loop/switch region; other site
591946010913	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
591946010914	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
591946010915	HlyD family secretion protein; Region: HlyD; pfam00529
591946010916	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946010917	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946010918	Protein of unknown function (DUF2776); Region: DUF2776; pfam10951
591946010919	Predicted flavoproteins [General function prediction only]; Region: COG2081
591946010920	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591946010921	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
591946010922	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
591946010923	universal stress protein UspB; Provisional; Region: PRK04960
591946010924	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591946010925	Ligand Binding Site [chemical binding]; other site
591946010926	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
591946010927	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946010928	POT family; Region: PTR2; pfam00854
591946010929	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946010930	S-adenosylmethionine binding site [chemical binding]; other site
591946010931	oligopeptidase A; Provisional; Region: PRK10911
591946010932	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
591946010933	active site
591946010934	Zn binding site [ion binding]; other site
591946010935	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
591946010936	glutathione reductase; Validated; Region: PRK06116
591946010937	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591946010938	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946010939	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
591946010940	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
591946010941	ArsC family; Region: ArsC; pfam03960
591946010942	catalytic residues [active]
591946010943	outer membrane lipoprotein, Slp family; Region: slp; TIGR00752
591946010944	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
591946010945	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946010946	DNA binding residues [nucleotide binding]
591946010947	dimerization interface [polypeptide binding]; other site
591946010948	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
591946010949	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
591946010950	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
591946010951	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
591946010952	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591946010953	N-terminal plug; other site
591946010954	ligand-binding site [chemical binding]; other site
591946010955	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
591946010956	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
591946010957	putative hemin binding site; other site
591946010958	coproporphyrinogen III oxidase; Provisional; Region: PRK09058
591946010959	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946010960	FeS/SAM binding site; other site
591946010961	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721
591946010962	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
591946010963	NADH(P)-binding; Region: NAD_binding_10; pfam13460
591946010964	NAD(P) binding site [chemical binding]; other site
591946010965	putative active site [active]
591946010966	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
591946010967	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591946010968	ABC-ATPase subunit  interface; other site
591946010969	dimer interface [polypeptide binding]; other site
591946010970	putative PBP binding regions; other site
591946010971	ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559
591946010972	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
591946010973	Walker A/P-loop; other site
591946010974	ATP binding site [chemical binding]; other site
591946010975	Q-loop/lid; other site
591946010976	ABC transporter signature motif; other site
591946010977	Walker B; other site
591946010978	D-loop; other site
591946010979	H-loop/switch region; other site
591946010980	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
591946010981	MgtC family; Region: MgtC; pfam02308
591946010982	acid-resistance protein; Provisional; Region: hdeB; PRK11566
591946010983	acid-resistance protein; Provisional; Region: PRK10208
591946010984	acid-resistance membrane protein; Provisional; Region: PRK10209
591946010985	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
591946010986	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
591946010987	pyruvate kinase; Provisional; Region: PRK05826
591946010988	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
591946010989	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946010990	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946010991	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
591946010992	Protein export membrane protein; Region: SecD_SecF; cl14618
591946010993	transcriptional regulator YdeO; Provisional; Region: PRK09940
591946010994	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946010995	DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978
591946010996	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946010997	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
591946010998	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946010999	catalytic residue [active]
591946011000	Haem-binding domain; Region: Haem_bd; pfam14376
591946011001	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
591946011002	trehalase; Provisional; Region: treF; PRK13270
591946011003	Trehalase; Region: Trehalase; pfam01204
591946011004	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
591946011005	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946011006	DNA binding residues [nucleotide binding]
591946011007	dimerization interface [polypeptide binding]; other site
591946011008	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591946011009	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946011010	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
591946011011	putative effector binding pocket; other site
591946011012	putative dimerization interface [polypeptide binding]; other site
591946011013	inner membrane protein YhjD; Region: TIGR00766
591946011014	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946011015	metabolite-proton symporter; Region: 2A0106; TIGR00883
591946011016	putative substrate translocation pore; other site
591946011017	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
591946011018	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
591946011019	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946011020	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591946011021	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
591946011022	substrate binding site [chemical binding]; other site
591946011023	ATP binding site [chemical binding]; other site
591946011024	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
591946011025	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
591946011026	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
591946011027	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
591946011028	putative diguanylate cyclase; Provisional; Region: PRK13561
591946011029	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591946011030	metal binding site [ion binding]; metal-binding site
591946011031	active site
591946011032	I-site; other site
591946011033	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946011034	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
591946011035	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591946011036	binding surface
591946011037	TPR motif; other site
591946011038	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591946011039	binding surface
591946011040	TPR motif; other site
591946011041	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
591946011042	TPR motif; other site
591946011043	binding surface
591946011044	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
591946011045	endo-1,4-D-glucanase; Provisional; Region: PRK11097
591946011046	cellulose synthase regulator protein; Provisional; Region: PRK11114
591946011047	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
591946011048	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
591946011049	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
591946011050	DXD motif; other site
591946011051	PilZ domain; Region: PilZ; pfam07238
591946011052	cell division protein; Provisional; Region: PRK10037
591946011053	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
591946011054	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
591946011055	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
591946011056	celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493
591946011057	Protein of unknown function (DUF3260); Region: DUF3260; pfam11658
591946011058	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
591946011059	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
591946011060	serine transporter; Region: stp; TIGR00814
591946011061	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
591946011062	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946011063	Walker A/P-loop; other site
591946011064	ATP binding site [chemical binding]; other site
591946011065	Q-loop/lid; other site
591946011066	ABC transporter signature motif; other site
591946011067	Walker B; other site
591946011068	D-loop; other site
591946011069	H-loop/switch region; other site
591946011070	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
591946011071	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
591946011072	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946011073	Walker A/P-loop; other site
591946011074	ATP binding site [chemical binding]; other site
591946011075	Q-loop/lid; other site
591946011076	ABC transporter signature motif; other site
591946011077	Walker B; other site
591946011078	D-loop; other site
591946011079	H-loop/switch region; other site
591946011080	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
591946011081	dipeptide transporter; Provisional; Region: PRK10913
591946011082	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
591946011083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946011084	dimer interface [polypeptide binding]; other site
591946011085	conserved gate region; other site
591946011086	putative PBP binding loops; other site
591946011087	ABC-ATPase subunit interface; other site
591946011088	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
591946011089	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946011090	dimer interface [polypeptide binding]; other site
591946011091	conserved gate region; other site
591946011092	putative PBP binding loops; other site
591946011093	ABC-ATPase subunit interface; other site
591946011094	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
591946011095	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
591946011096	peptide binding site [polypeptide binding]; other site
591946011097	phosphoethanolamine transferase; Provisional; Region: PRK11560
591946011098	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
591946011099	Sulfatase; Region: Sulfatase; pfam00884
591946011100	long polar fimbrial protein LpfE; Provisional; Region: PRK15205
591946011101	Fimbrial protein; Region: Fimbrial; cl01416
591946011102	long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207
591946011103	PapC N-terminal domain; Region: PapC_N; pfam13954
591946011104	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591946011105	PapC C-terminal domain; Region: PapC_C; pfam13953
591946011106	long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208
591946011107	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591946011108	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591946011109	long polar fimbrial protein LpfA; Provisional; Region: PRK15209
591946011110	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
591946011111	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946011112	putative substrate translocation pore; other site
591946011113	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
591946011114	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
591946011115	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
591946011116	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946011117	Coenzyme A binding pocket [chemical binding]; other site
591946011118	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
591946011119	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
591946011120	molybdopterin cofactor binding site [chemical binding]; other site
591946011121	substrate binding site [chemical binding]; other site
591946011122	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
591946011123	molybdopterin cofactor binding site; other site
591946011124	putative outer membrane lipoprotein; Provisional; Region: PRK10510
591946011125	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
591946011126	ligand binding site [chemical binding]; other site
591946011127	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
591946011128	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
591946011129	dimerization interface [polypeptide binding]; other site
591946011130	ligand binding site [chemical binding]; other site
591946011131	NADP binding site [chemical binding]; other site
591946011132	catalytic site [active]
591946011133	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
591946011134	Predicted transcriptional regulator [Transcription]; Region: COG2944
591946011135	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946011136	non-specific DNA binding site [nucleotide binding]; other site
591946011137	salt bridge; other site
591946011138	sequence-specific DNA binding site [nucleotide binding]; other site
591946011139	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591946011140	DNA-binding site [nucleotide binding]; DNA binding site
591946011141	RNA-binding motif; other site
591946011142	small toxic polypeptide; Provisional; Region: PRK09759
591946011143	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
591946011144	DALR anticodon binding domain; Region: DALR_1; pfam05746
591946011145	anticodon binding site; other site
591946011146	tRNA binding surface [nucleotide binding]; other site
591946011147	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
591946011148	dimer interface [polypeptide binding]; other site
591946011149	motif 1; other site
591946011150	active site
591946011151	motif 2; other site
591946011152	motif 3; other site
591946011153	YsaB-like lipoprotein; Region: YsaB; pfam13983
591946011154	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
591946011155	Acyltransferase family; Region: Acyl_transf_3; pfam01757
591946011156	hypothetical protein; Provisional; Region: PRK11383
591946011157	yiaA/B two helix domain; Region: YiaAB; pfam05360
591946011158	yiaA/B two helix domain; Region: YiaAB; pfam05360
591946011159	hypothetical protein; Provisional; Region: PRK11403
591946011160	yiaA/B two helix domain; Region: YiaAB; pfam05360
591946011161	xylulokinase; Provisional; Region: PRK15027
591946011162	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
591946011163	N- and C-terminal domain interface [polypeptide binding]; other site
591946011164	active site
591946011165	MgATP binding site [chemical binding]; other site
591946011166	catalytic site [active]
591946011167	metal binding site [ion binding]; metal-binding site
591946011168	xylulose binding site [chemical binding]; other site
591946011169	homodimer interface [polypeptide binding]; other site
591946011170	xylose isomerase; Provisional; Region: PRK05474
591946011171	xylose isomerase; Region: xylose_isom_A; TIGR02630
591946011172	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
591946011173	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
591946011174	putative ligand binding site [chemical binding]; other site
591946011175	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
591946011176	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591946011177	Walker A/P-loop; other site
591946011178	ATP binding site [chemical binding]; other site
591946011179	Q-loop/lid; other site
591946011180	ABC transporter signature motif; other site
591946011181	Walker B; other site
591946011182	D-loop; other site
591946011183	H-loop/switch region; other site
591946011184	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591946011185	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591946011186	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591946011187	TM-ABC transporter signature motif; other site
591946011188	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
591946011189	putative dimerization interface [polypeptide binding]; other site
591946011190	Transcriptional regulators [Transcription]; Region: PurR; COG1609
591946011191	putative ligand binding site [chemical binding]; other site
591946011192	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946011193	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591946011194	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946011195	hypothetical protein; Provisional; Region: PRK10356
591946011196	Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992
591946011197	alpha-amylase; Reviewed; Region: malS; PRK09505
591946011198	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
591946011199	active site
591946011200	catalytic site [active]
591946011201	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
591946011202	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591946011203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946011204	homodimer interface [polypeptide binding]; other site
591946011205	catalytic residue [active]
591946011206	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
591946011207	Transcriptional regulator [Transcription]; Region: IclR; COG1414
591946011208	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
591946011209	Bacterial transcriptional regulator; Region: IclR; pfam01614
591946011210	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
591946011211	Domain of unknown function (DUF386); Region: DUF386; pfam04074
591946011212	2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877
591946011213	L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060
591946011214	DctM-like transporters; Region: DctM; pfam06808
591946011215	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
591946011216	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
591946011217	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
591946011218	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
591946011219	putative N- and C-terminal domain interface [polypeptide binding]; other site
591946011220	putative active site [active]
591946011221	MgATP binding site [chemical binding]; other site
591946011222	catalytic site [active]
591946011223	metal binding site [ion binding]; metal-binding site
591946011224	putative xylulose binding site [chemical binding]; other site
591946011225	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
591946011226	active site
591946011227	dimer interface [polypeptide binding]; other site
591946011228	magnesium binding site [ion binding]; other site
591946011229	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
591946011230	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
591946011231	AP (apurinic/apyrimidinic) site pocket; other site
591946011232	DNA interaction; other site
591946011233	Metal-binding active site; metal-binding site
591946011234	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
591946011235	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
591946011236	intersubunit interface [polypeptide binding]; other site
591946011237	active site
591946011238	Zn2+ binding site [ion binding]; other site
591946011239	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
591946011240	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
591946011241	NAD(P) binding site [chemical binding]; other site
591946011242	catalytic residues [active]
591946011243	Fic family protein [Function unknown]; Region: COG3177
591946011244	Fic/DOC family; Region: Fic; pfam02661
591946011245	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
591946011246	putative alcohol dehydrogenase; Provisional; Region: PRK09860
591946011247	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
591946011248	dimer interface [polypeptide binding]; other site
591946011249	active site
591946011250	metal binding site [ion binding]; metal-binding site
591946011251	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
591946011252	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
591946011253	G1 box; other site
591946011254	putative GEF interaction site [polypeptide binding]; other site
591946011255	GTP/Mg2+ binding site [chemical binding]; other site
591946011256	Switch I region; other site
591946011257	G2 box; other site
591946011258	G3 box; other site
591946011259	Switch II region; other site
591946011260	G4 box; other site
591946011261	G5 box; other site
591946011262	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
591946011263	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
591946011264	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
591946011265	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
591946011266	selenocysteine synthase; Provisional; Region: PRK04311
591946011267	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
591946011268	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
591946011269	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591946011270	catalytic residue [active]
591946011271	putative glutathione S-transferase; Provisional; Region: PRK10357
591946011272	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
591946011273	putative C-terminal domain interface [polypeptide binding]; other site
591946011274	putative GSH binding site (G-site) [chemical binding]; other site
591946011275	putative dimer interface [polypeptide binding]; other site
591946011276	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
591946011277	dimer interface [polypeptide binding]; other site
591946011278	N-terminal domain interface [polypeptide binding]; other site
591946011279	putative substrate binding pocket (H-site) [chemical binding]; other site
591946011280	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
591946011281	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946011282	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946011283	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
591946011284	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
591946011285	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
591946011286	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
591946011287	active site
591946011288	P-loop; other site
591946011289	phosphorylation site [posttranslational modification]
591946011290	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591946011291	active site
591946011292	phosphorylation site [posttranslational modification]
591946011293	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
591946011294	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
591946011295	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
591946011296	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
591946011297	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
591946011298	hypothetical protein; Provisional; Region: PRK11020
591946011299	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
591946011300	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
591946011301	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
591946011302	trimer interface [polypeptide binding]; other site
591946011303	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
591946011304	trimer interface [polypeptide binding]; other site
591946011305	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
591946011306	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
591946011307	trimer interface [polypeptide binding]; other site
591946011308	Haemagglutinin; Region: HIM; pfam05662
591946011309	Haemagglutinin; Region: HIM; pfam05662
591946011310	YadA-like C-terminal region; Region: YadA; pfam03895
591946011311	L-lactate permease; Provisional; Region: PRK10420
591946011312	glycolate transporter; Provisional; Region: PRK09695
591946011313	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
591946011314	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946011315	DNA-binding site [nucleotide binding]; DNA binding site
591946011316	FCD domain; Region: FCD; pfam07729
591946011317	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
591946011318	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
591946011319	phosphate binding site [ion binding]; other site
591946011320	putative rRNA methylase; Provisional; Region: PRK10358
591946011321	serine acetyltransferase; Provisional; Region: cysE; PRK11132
591946011322	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
591946011323	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
591946011324	trimer interface [polypeptide binding]; other site
591946011325	active site
591946011326	substrate binding site [chemical binding]; other site
591946011327	CoA binding site [chemical binding]; other site
591946011328	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
591946011329	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
591946011330	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
591946011331	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
591946011332	SecA binding site; other site
591946011333	Preprotein binding site; other site
591946011334	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
591946011335	GSH binding site [chemical binding]; other site
591946011336	catalytic residues [active]
591946011337	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
591946011338	active site residue [active]
591946011339	phosphoglyceromutase; Provisional; Region: PRK05434
591946011340	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
591946011341	AmiB activator; Provisional; Region: PRK11637
591946011342	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
591946011343	Peptidase family M23; Region: Peptidase_M23; pfam01551
591946011344	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
591946011345	NodB motif; other site
591946011346	putative active site [active]
591946011347	putative catalytic site [active]
591946011348	Zn binding site [ion binding]; other site
591946011349	putative glycosyl transferase; Provisional; Region: PRK10073
591946011350	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
591946011351	active site
591946011352	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
591946011353	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
591946011354	NAD(P) binding site [chemical binding]; other site
591946011355	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
591946011356	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
591946011357	substrate-cofactor binding pocket; other site
591946011358	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946011359	catalytic residue [active]
591946011360	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
591946011361	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
591946011362	NADP binding site [chemical binding]; other site
591946011363	homopentamer interface [polypeptide binding]; other site
591946011364	substrate binding site [chemical binding]; other site
591946011365	active site
591946011366	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
591946011367	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
591946011368	putative active site [active]
591946011369	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
591946011370	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
591946011371	putative active site [active]
591946011372	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
591946011373	O-Antigen ligase; Region: Wzy_C; pfam04932
591946011374	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
591946011375	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
591946011376	active site
591946011377	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
591946011378	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
591946011379	Ligand binding site; other site
591946011380	metal-binding site
591946011381	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
591946011382	Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176
591946011383	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
591946011384	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
591946011385	Ligand binding site; other site
591946011386	metal-binding site
591946011387	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
591946011388	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
591946011389	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
591946011390	Ligand binding site; other site
591946011391	metal-binding site
591946011392	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
591946011393	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
591946011394	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
591946011395	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
591946011396	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
591946011397	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
591946011398	putative active site [active]
591946011399	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
591946011400	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
591946011401	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
591946011402	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
591946011403	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
591946011404	active site
591946011405	(T/H)XGH motif; other site
591946011406	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
591946011407	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
591946011408	DNA binding site [nucleotide binding]
591946011409	catalytic residue [active]
591946011410	H2TH interface [polypeptide binding]; other site
591946011411	putative catalytic residues [active]
591946011412	turnover-facilitating residue; other site
591946011413	intercalation triad [nucleotide binding]; other site
591946011414	8OG recognition residue [nucleotide binding]; other site
591946011415	putative reading head residues; other site
591946011416	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
591946011417	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
591946011418	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
591946011419	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
591946011420	hypothetical protein; Reviewed; Region: PRK00024
591946011421	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
591946011422	MPN+ (JAMM) motif; other site
591946011423	Zinc-binding site [ion binding]; other site
591946011424	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
591946011425	Flavoprotein; Region: Flavoprotein; pfam02441
591946011426	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
591946011427	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
591946011428	trimer interface [polypeptide binding]; other site
591946011429	active site
591946011430	division inhibitor protein; Provisional; Region: slmA; PRK09480
591946011431	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591946011432	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591946011433	active site
591946011434	ribonuclease PH; Reviewed; Region: rph; PRK00173
591946011435	Ribonuclease PH; Region: RNase_PH_bact; cd11362
591946011436	hexamer interface [polypeptide binding]; other site
591946011437	active site
591946011438	hypothetical protein; Provisional; Region: PRK11820
591946011439	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
591946011440	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
591946011441	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
591946011442	BRO family, N-terminal domain; Region: Bro-N; pfam02498
591946011443	Predicted membrane protein [Function unknown]; Region: COG2860
591946011444	UPF0126 domain; Region: UPF0126; pfam03458
591946011445	UPF0126 domain; Region: UPF0126; pfam03458
591946011446	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
591946011447	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
591946011448	nucleotide binding pocket [chemical binding]; other site
591946011449	K-X-D-G motif; other site
591946011450	catalytic site [active]
591946011451	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
591946011452	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
591946011453	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
591946011454	catalytic site [active]
591946011455	G-X2-G-X-G-K; other site
591946011456	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
591946011457	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
591946011458	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591946011459	Zn2+ binding site [ion binding]; other site
591946011460	Mg2+ binding site [ion binding]; other site
591946011461	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
591946011462	synthetase active site [active]
591946011463	NTP binding site [chemical binding]; other site
591946011464	metal binding site [ion binding]; metal-binding site
591946011465	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
591946011466	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
591946011467	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
591946011468	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
591946011469	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
591946011470	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
591946011471	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
591946011472	generic binding surface II; other site
591946011473	ssDNA binding site; other site
591946011474	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591946011475	ATP binding site [chemical binding]; other site
591946011476	putative Mg++ binding site [ion binding]; other site
591946011477	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591946011478	nucleotide binding region [chemical binding]; other site
591946011479	ATP-binding site [chemical binding]; other site
591946011480	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
591946011481	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
591946011482	AsmA family; Region: AsmA; pfam05170
591946011483	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
591946011484	Protein of unknown function (DUF1498); Region: DUF1498; pfam07385
591946011485	fructokinase; Reviewed; Region: PRK09557
591946011486	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591946011487	nucleotide binding site [chemical binding]; other site
591946011488	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
591946011489	intersubunit interface [polypeptide binding]; other site
591946011490	active site
591946011491	zinc binding site [ion binding]; other site
591946011492	Na+ binding site [ion binding]; other site
591946011493	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
591946011494	intersubunit interface [polypeptide binding]; other site
591946011495	active site
591946011496	zinc binding site [ion binding]; other site
591946011497	Na+ binding site [ion binding]; other site
591946011498	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
591946011499	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
591946011500	active site
591946011501	P-loop; other site
591946011502	phosphorylation site [posttranslational modification]
591946011503	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591946011504	active site
591946011505	phosphorylation site [posttranslational modification]
591946011506	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
591946011507	HTH domain; Region: HTH_11; pfam08279
591946011508	Mga helix-turn-helix domain; Region: Mga; pfam05043
591946011509	PRD domain; Region: PRD; pfam00874
591946011510	PRD domain; Region: PRD; pfam00874
591946011511	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
591946011512	active site
591946011513	P-loop; other site
591946011514	phosphorylation site [posttranslational modification]
591946011515	putative alpha-glucosidase; Provisional; Region: PRK10658
591946011516	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
591946011517	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
591946011518	active site
591946011519	homotrimer interface [polypeptide binding]; other site
591946011520	catalytic site [active]
591946011521	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
591946011522	putative transporter; Provisional; Region: PRK11462
591946011523	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
591946011524	Virulence protein [General function prediction only]; Region: COG3943
591946011525	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
591946011526	Virulence protein [General function prediction only]; Region: COG3943
591946011527	EamA-like transporter family; Region: EamA; pfam00892
591946011528	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
591946011529	EamA-like transporter family; Region: EamA; pfam00892
591946011530	cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861
591946011531	lipoprotein, YaeC family; Region: TIGR00363
591946011532	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
591946011533	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946011534	putative substrate translocation pore; other site
591946011535	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
591946011536	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
591946011537	cryptic adenine deaminase; Provisional; Region: PRK10027
591946011538	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
591946011539	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
591946011540	active site
591946011541	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
591946011542	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
591946011543	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946011544	putative substrate translocation pore; other site
591946011545	regulatory protein UhpC; Provisional; Region: PRK11663
591946011546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946011547	putative substrate translocation pore; other site
591946011548	sensory histidine kinase UhpB; Provisional; Region: PRK11644
591946011549	MASE1; Region: MASE1; pfam05231
591946011550	Histidine kinase; Region: HisKA_3; pfam07730
591946011551	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946011552	ATP binding site [chemical binding]; other site
591946011553	Mg2+ binding site [ion binding]; other site
591946011554	G-X-G motif; other site
591946011555	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
591946011556	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946011557	active site
591946011558	phosphorylation site [posttranslational modification]
591946011559	intermolecular recognition site; other site
591946011560	dimerization interface [polypeptide binding]; other site
591946011561	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946011562	DNA binding residues [nucleotide binding]
591946011563	dimerization interface [polypeptide binding]; other site
591946011564	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
591946011565	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
591946011566	putative valine binding site [chemical binding]; other site
591946011567	dimer interface [polypeptide binding]; other site
591946011568	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
591946011569	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
591946011570	PYR/PP interface [polypeptide binding]; other site
591946011571	dimer interface [polypeptide binding]; other site
591946011572	TPP binding site [chemical binding]; other site
591946011573	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591946011574	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
591946011575	TPP-binding site [chemical binding]; other site
591946011576	dimer interface [polypeptide binding]; other site
591946011577	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
591946011578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946011579	putative substrate translocation pore; other site
591946011580	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
591946011581	Domain of unknown function (DUF202); Region: DUF202; pfam02656
591946011582	Predicted membrane protein [Function unknown]; Region: COG2149
591946011583	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
591946011584	Sulfatase; Region: Sulfatase; pfam00884
591946011585	putative transporter; Provisional; Region: PRK10484
591946011586	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
591946011587	Na binding site [ion binding]; other site
591946011588	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
591946011589	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946011590	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591946011591	putative transporter; Validated; Region: PRK03818
591946011592	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
591946011593	TrkA-C domain; Region: TrkA_C; pfam02080
591946011594	TrkA-C domain; Region: TrkA_C; pfam02080
591946011595	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
591946011596	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
591946011597	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
591946011598	putative dimer interface [polypeptide binding]; other site
591946011599	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
591946011600	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
591946011601	putative dimer interface [polypeptide binding]; other site
591946011602	hypothetical protein; Provisional; Region: PRK11616
591946011603	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
591946011604	putative oxidoreductase; Provisional; Region: PRK11445
591946011605	hypothetical protein; Provisional; Region: PRK07236
591946011606	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946011607	D-galactonate transporter; Region: 2A0114; TIGR00893
591946011608	putative substrate translocation pore; other site
591946011609	galactonate dehydratase; Provisional; Region: PRK14017
591946011610	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
591946011611	putative active site pocket [active]
591946011612	putative metal binding site [ion binding]; other site
591946011613	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
591946011614	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
591946011615	active site
591946011616	intersubunit interface [polypeptide binding]; other site
591946011617	catalytic residue [active]
591946011618	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
591946011619	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
591946011620	Transcriptional regulators [Transcription]; Region: FadR; COG2186
591946011621	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946011622	DNA-binding site [nucleotide binding]; DNA binding site
591946011623	FCD domain; Region: FCD; pfam07729
591946011624	hypothetical protein; Provisional; Region: PRK10215
591946011625	sugar phosphate phosphatase; Provisional; Region: PRK10513
591946011626	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946011627	active site
591946011628	motif I; other site
591946011629	motif II; other site
591946011630	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946011631	hypothetical protein; Provisional; Region: PRK11426
591946011632	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
591946011633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946011634	Mg2+ binding site [ion binding]; other site
591946011635	G-X-G motif; other site
591946011636	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
591946011637	anchoring element; other site
591946011638	dimer interface [polypeptide binding]; other site
591946011639	ATP binding site [chemical binding]; other site
591946011640	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
591946011641	active site
591946011642	putative metal-binding site [ion binding]; other site
591946011643	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
591946011644	recF protein; Region: recf; TIGR00611
591946011645	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946011646	Walker A/P-loop; other site
591946011647	ATP binding site [chemical binding]; other site
591946011648	Q-loop/lid; other site
591946011649	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946011650	ABC transporter signature motif; other site
591946011651	Walker B; other site
591946011652	D-loop; other site
591946011653	H-loop/switch region; other site
591946011654	DNA polymerase III subunit beta; Validated; Region: PRK05643
591946011655	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
591946011656	putative DNA binding surface [nucleotide binding]; other site
591946011657	dimer interface [polypeptide binding]; other site
591946011658	beta-clamp/clamp loader binding surface; other site
591946011659	beta-clamp/translesion DNA polymerase binding surface; other site
591946011660	DnaA N-terminal domain; Region: DnaA_N; pfam11638
591946011661	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
591946011662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946011663	Walker A motif; other site
591946011664	ATP binding site [chemical binding]; other site
591946011665	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
591946011666	Walker B motif; other site
591946011667	arginine finger; other site
591946011668	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
591946011669	DnaA box-binding interface [nucleotide binding]; other site
591946011670	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
591946011671	ribonuclease P; Reviewed; Region: rnpA; PRK01732
591946011672	hypothetical protein; Validated; Region: PRK00041
591946011673	membrane protein insertase; Provisional; Region: PRK01318
591946011674	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
591946011675	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
591946011676	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
591946011677	trmE is a tRNA modification GTPase; Region: trmE; cd04164
591946011678	G1 box; other site
591946011679	GTP/Mg2+ binding site [chemical binding]; other site
591946011680	Switch I region; other site
591946011681	G2 box; other site
591946011682	Switch II region; other site
591946011683	G3 box; other site
591946011684	G4 box; other site
591946011685	G5 box; other site
591946011686	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
591946011687	tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617
591946011688	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
591946011689	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591946011690	catalytic residue [active]
591946011691	tryptophan permease TnaB; Provisional; Region: PRK09664
591946011692	aromatic amino acid transport protein; Region: araaP; TIGR00837
591946011693	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
591946011694	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946011695	putative substrate translocation pore; other site
591946011696	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
591946011697	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946011698	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
591946011699	substrate binding pocket [chemical binding]; other site
591946011700	dimerization interface [polypeptide binding]; other site
591946011701	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
591946011702	Predicted flavoprotein [General function prediction only]; Region: COG0431
591946011703	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
591946011704	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
591946011705	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
591946011706	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946011707	active site
591946011708	motif I; other site
591946011709	motif II; other site
591946011710	putative inner membrane protein; Provisional; Region: PRK09823
591946011711	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
591946011712	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
591946011713	active site
591946011714	trimer interface [polypeptide binding]; other site
591946011715	allosteric site; other site
591946011716	active site lid [active]
591946011717	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
591946011718	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
591946011719	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
591946011720	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
591946011721	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
591946011722	trimer interface; other site
591946011723	sugar binding site [chemical binding]; other site
591946011724	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
591946011725	beta-galactosidase; Region: BGL; TIGR03356
591946011726	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
591946011727	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591946011728	active site turn [active]
591946011729	phosphorylation site [posttranslational modification]
591946011730	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591946011731	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
591946011732	HPr interaction site; other site
591946011733	glycerol kinase (GK) interaction site [polypeptide binding]; other site
591946011734	active site
591946011735	phosphorylation site [posttranslational modification]
591946011736	transcriptional antiterminator BglG; Provisional; Region: PRK09772
591946011737	CAT RNA binding domain; Region: CAT_RBD; pfam03123
591946011738	PRD domain; Region: PRD; pfam00874
591946011739	PRD domain; Region: PRD; pfam00874
591946011740	transcriptional regulator PhoU; Provisional; Region: PRK11115
591946011741	PhoU domain; Region: PhoU; pfam01895
591946011742	PhoU domain; Region: PhoU; pfam01895
591946011743	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
591946011744	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
591946011745	Walker A/P-loop; other site
591946011746	ATP binding site [chemical binding]; other site
591946011747	Q-loop/lid; other site
591946011748	ABC transporter signature motif; other site
591946011749	Walker B; other site
591946011750	D-loop; other site
591946011751	H-loop/switch region; other site
591946011752	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
591946011753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946011754	dimer interface [polypeptide binding]; other site
591946011755	conserved gate region; other site
591946011756	putative PBP binding loops; other site
591946011757	ABC-ATPase subunit interface; other site
591946011758	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
591946011759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946011760	dimer interface [polypeptide binding]; other site
591946011761	conserved gate region; other site
591946011762	putative PBP binding loops; other site
591946011763	ABC-ATPase subunit interface; other site
591946011764	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946011765	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
591946011766	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
591946011767	glutaminase active site [active]
591946011768	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
591946011769	dimer interface [polypeptide binding]; other site
591946011770	active site
591946011771	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
591946011772	dimer interface [polypeptide binding]; other site
591946011773	active site
591946011774	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
591946011775	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
591946011776	Substrate binding site; other site
591946011777	Mg++ binding site; other site
591946011778	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
591946011779	active site
591946011780	substrate binding site [chemical binding]; other site
591946011781	CoA binding site [chemical binding]; other site
591946011782	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
591946011783	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
591946011784	gamma subunit interface [polypeptide binding]; other site
591946011785	epsilon subunit interface [polypeptide binding]; other site
591946011786	LBP interface [polypeptide binding]; other site
591946011787	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
591946011788	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
591946011789	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
591946011790	alpha subunit interaction interface [polypeptide binding]; other site
591946011791	Walker A motif; other site
591946011792	ATP binding site [chemical binding]; other site
591946011793	Walker B motif; other site
591946011794	inhibitor binding site; inhibition site
591946011795	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
591946011796	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
591946011797	core domain interface [polypeptide binding]; other site
591946011798	delta subunit interface [polypeptide binding]; other site
591946011799	epsilon subunit interface [polypeptide binding]; other site
591946011800	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
591946011801	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
591946011802	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
591946011803	beta subunit interaction interface [polypeptide binding]; other site
591946011804	Walker A motif; other site
591946011805	ATP binding site [chemical binding]; other site
591946011806	Walker B motif; other site
591946011807	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
591946011808	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
591946011809	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
591946011810	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
591946011811	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
591946011812	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
591946011813	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
591946011814	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
591946011815	F0F1 ATP synthase subunit I; Validated; Region: PRK08049
591946011816	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
591946011817	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946011818	S-adenosylmethionine binding site [chemical binding]; other site
591946011819	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
591946011820	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
591946011821	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
591946011822	FMN-binding protein MioC; Provisional; Region: PRK09004
591946011823	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
591946011824	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591946011825	putative DNA binding site [nucleotide binding]; other site
591946011826	putative Zn2+ binding site [ion binding]; other site
591946011827	AsnC family; Region: AsnC_trans_reg; pfam01037
591946011828	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
591946011829	dimer interface [polypeptide binding]; other site
591946011830	active site
591946011831	hypothetical protein; Provisional; Region: yieM; PRK10997
591946011832	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
591946011833	metal ion-dependent adhesion site (MIDAS); other site
591946011834	regulatory ATPase RavA; Provisional; Region: PRK13531
591946011835	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946011836	Walker A motif; other site
591946011837	ATP binding site [chemical binding]; other site
591946011838	Walker B motif; other site
591946011839	arginine finger; other site
591946011840	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
591946011841	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
591946011842	potassium uptake protein; Region: kup; TIGR00794
591946011843	D-ribose pyranase; Provisional; Region: PRK11797
591946011844	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
591946011845	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591946011846	Walker A/P-loop; other site
591946011847	ATP binding site [chemical binding]; other site
591946011848	Q-loop/lid; other site
591946011849	ABC transporter signature motif; other site
591946011850	Walker B; other site
591946011851	D-loop; other site
591946011852	H-loop/switch region; other site
591946011853	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591946011854	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591946011855	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591946011856	TM-ABC transporter signature motif; other site
591946011857	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
591946011858	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
591946011859	ligand binding site [chemical binding]; other site
591946011860	dimerization interface [polypeptide binding]; other site
591946011861	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
591946011862	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591946011863	substrate binding site [chemical binding]; other site
591946011864	dimer interface [polypeptide binding]; other site
591946011865	ATP binding site [chemical binding]; other site
591946011866	transcriptional repressor RbsR; Provisional; Region: PRK10423
591946011867	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946011868	DNA binding site [nucleotide binding]
591946011869	domain linker motif; other site
591946011870	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
591946011871	dimerization interface [polypeptide binding]; other site
591946011872	ligand binding site [chemical binding]; other site
591946011873	putative transporter; Provisional; Region: PRK10504
591946011874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946011875	putative substrate translocation pore; other site
591946011876	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946011877	Transcriptional regulators [Transcription]; Region: FadR; COG2186
591946011878	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946011879	DNA-binding site [nucleotide binding]; DNA binding site
591946011880	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591946011881	transcriptional regulator HdfR; Provisional; Region: PRK03601
591946011882	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946011883	LysR substrate binding domain; Region: LysR_substrate; pfam03466
591946011884	dimerization interface [polypeptide binding]; other site
591946011885	hypothetical protein; Provisional; Region: PRK11027
591946011886	putative ATP-dependent protease; Provisional; Region: PRK09862
591946011887	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
591946011888	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946011889	Walker A motif; other site
591946011890	ATP binding site [chemical binding]; other site
591946011891	Walker B motif; other site
591946011892	arginine finger; other site
591946011893	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
591946011894	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
591946011895	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
591946011896	PYR/PP interface [polypeptide binding]; other site
591946011897	dimer interface [polypeptide binding]; other site
591946011898	TPP binding site [chemical binding]; other site
591946011899	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591946011900	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
591946011901	TPP-binding site [chemical binding]; other site
591946011902	dimer interface [polypeptide binding]; other site
591946011903	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
591946011904	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
591946011905	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
591946011906	homodimer interface [polypeptide binding]; other site
591946011907	substrate-cofactor binding pocket; other site
591946011908	catalytic residue [active]
591946011909	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
591946011910	threonine dehydratase; Reviewed; Region: PRK09224
591946011911	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
591946011912	tetramer interface [polypeptide binding]; other site
591946011913	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946011914	catalytic residue [active]
591946011915	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
591946011916	putative Ile/Val binding site [chemical binding]; other site
591946011917	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
591946011918	putative Ile/Val binding site [chemical binding]; other site
591946011919	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946011920	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
591946011921	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
591946011922	putative dimerization interface [polypeptide binding]; other site
591946011923	ketol-acid reductoisomerase; Validated; Region: PRK05225
591946011924	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
591946011925	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
591946011926	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
591946011927	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
591946011928	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
591946011929	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
591946011930	Part of AAA domain; Region: AAA_19; pfam13245
591946011931	Family description; Region: UvrD_C_2; pfam13538
591946011932	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
591946011933	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
591946011934	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
591946011935	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
591946011936	ATP binding site [chemical binding]; other site
591946011937	Mg++ binding site [ion binding]; other site
591946011938	motif III; other site
591946011939	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591946011940	nucleotide binding region [chemical binding]; other site
591946011941	ATP-binding site [chemical binding]; other site
591946011942	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
591946011943	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
591946011944	catalytic residues [active]
591946011945	transcription termination factor Rho; Provisional; Region: rho; PRK09376
591946011946	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
591946011947	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
591946011948	RNA binding site [nucleotide binding]; other site
591946011949	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
591946011950	multimer interface [polypeptide binding]; other site
591946011951	Walker A motif; other site
591946011952	ATP binding site [chemical binding]; other site
591946011953	Walker B motif; other site
591946011954	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
591946011955	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
591946011956	Mg++ binding site [ion binding]; other site
591946011957	putative catalytic motif [active]
591946011958	substrate binding site [chemical binding]; other site
591946011959	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
591946011960	Chain length determinant protein; Region: Wzz; pfam02706
591946011961	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
591946011962	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
591946011963	active site
591946011964	homodimer interface [polypeptide binding]; other site
591946011965	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
591946011966	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
591946011967	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
591946011968	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
591946011969	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
591946011970	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
591946011971	NAD binding site [chemical binding]; other site
591946011972	substrate binding site [chemical binding]; other site
591946011973	homodimer interface [polypeptide binding]; other site
591946011974	active site
591946011975	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
591946011976	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
591946011977	substrate binding site; other site
591946011978	tetramer interface; other site
591946011979	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
591946011980	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
591946011981	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
591946011982	inhibitor-cofactor binding pocket; inhibition site
591946011983	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946011984	catalytic residue [active]
591946011985	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
591946011986	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
591946011987	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
591946011988	putative common antigen polymerase; Provisional; Region: PRK02975
591946011989	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
591946011990	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
591946011991	putative transport protein YifK; Provisional; Region: PRK10746
591946011992	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
591946011993	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946011994	FeS/SAM binding site; other site
591946011995	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
591946011996	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
591946011997	Sulfatase; Region: Sulfatase; pfam00884
591946011998	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
591946011999	HemY protein N-terminus; Region: HemY_N; pfam07219
591946012000	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
591946012001	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
591946012002	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
591946012003	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
591946012004	active site
591946012005	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
591946012006	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
591946012007	domain interfaces; other site
591946012008	active site
591946012009	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
591946012010	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
591946012011	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
591946012012	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
591946012013	putative iron binding site [ion binding]; other site
591946012014	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
591946012015	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
591946012016	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
591946012017	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
591946012018	hypothetical protein; Provisional; Region: PRK10963
591946012019	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
591946012020	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591946012021	active site
591946012022	DNA binding site [nucleotide binding]
591946012023	Int/Topo IB signature motif; other site
591946012024	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
591946012025	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946012026	motif II; other site
591946012027	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
591946012028	Part of AAA domain; Region: AAA_19; pfam13245
591946012029	Family description; Region: UvrD_C_2; pfam13538
591946012030	Uncharacterized conserved protein [Function unknown]; Region: COG1912
591946012031	Predicted periplasmic protein [Function unknown]; Region: COG3698
591946012032	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
591946012033	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
591946012034	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
591946012035	Cl binding site [ion binding]; other site
591946012036	oligomer interface [polypeptide binding]; other site
591946012037	Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092
591946012038	Protein of unknown function (DUF3289); Region: DUF3289; cl11840
591946012039	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
591946012040	EamA-like transporter family; Region: EamA; cl17759
591946012041	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
591946012042	CoenzymeA binding site [chemical binding]; other site
591946012043	subunit interaction site [polypeptide binding]; other site
591946012044	PHB binding site; other site
591946012045	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
591946012046	dimerization interface [polypeptide binding]; other site
591946012047	substrate binding site [chemical binding]; other site
591946012048	active site
591946012049	calcium binding site [ion binding]; other site
591946012050	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
591946012051	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591946012052	ATP binding site [chemical binding]; other site
591946012053	putative Mg++ binding site [ion binding]; other site
591946012054	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591946012055	nucleotide binding region [chemical binding]; other site
591946012056	ATP-binding site [chemical binding]; other site
591946012057	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
591946012058	Helicase and RNase D C-terminal; Region: HRDC; smart00341
591946012059	threonine efflux system; Provisional; Region: PRK10229
591946012060	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
591946012061	lysophospholipase L2; Provisional; Region: PRK10749
591946012062	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
591946012063	putative hydrolase; Provisional; Region: PRK10976
591946012064	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946012065	active site
591946012066	motif I; other site
591946012067	motif II; other site
591946012068	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946012069	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
591946012070	EamA-like transporter family; Region: EamA; pfam00892
591946012071	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
591946012072	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946012073	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
591946012074	putative dimerization interface [polypeptide binding]; other site
591946012075	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
591946012076	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
591946012077	THF binding site; other site
591946012078	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
591946012079	substrate binding site [chemical binding]; other site
591946012080	THF binding site; other site
591946012081	zinc-binding site [ion binding]; other site
591946012082	Protein of unknown function (DUF796); Region: DUF796; cl01226
591946012083	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
591946012084	tetramer interface [polypeptide binding]; other site
591946012085	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
591946012086	active site
591946012087	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
591946012088	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591946012089	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591946012090	active site turn [active]
591946012091	phosphorylation site [posttranslational modification]
591946012092	transketolase; Reviewed; Region: PRK12753
591946012093	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
591946012094	TPP-binding site [chemical binding]; other site
591946012095	dimer interface [polypeptide binding]; other site
591946012096	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
591946012097	PYR/PP interface [polypeptide binding]; other site
591946012098	dimer interface [polypeptide binding]; other site
591946012099	TPP binding site [chemical binding]; other site
591946012100	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
591946012101	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
591946012102	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
591946012103	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
591946012104	putative active site [active]
591946012105	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
591946012106	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946012107	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591946012108	dimerization interface [polypeptide binding]; other site
591946012109	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
591946012110	Na binding site [ion binding]; other site
591946012111	allophanate hydrolase; Provisional; Region: PRK08186
591946012112	carbamate kinase; Reviewed; Region: PRK12686
591946012113	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
591946012114	putative substrate binding site [chemical binding]; other site
591946012115	nucleotide binding site [chemical binding]; other site
591946012116	nucleotide binding site [chemical binding]; other site
591946012117	homodimer interface [polypeptide binding]; other site
591946012118	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
591946012119	CoA binding domain; Region: CoA_binding; pfam02629
591946012120	CoA-ligase; Region: Ligase_CoA; pfam00549
591946012121	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
591946012122	Isochorismatase family; Region: Isochorismatase; pfam00857
591946012123	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
591946012124	catalytic triad [active]
591946012125	conserved cis-peptide bond; other site
591946012126	Dienelactone hydrolase family; Region: DLH; pfam01738
591946012127	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
591946012128	uridine phosphorylase; Provisional; Region: PRK11178
591946012129	uridine phosphorylase; Region: Uridine-psphlse; TIGR01718
591946012130	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
591946012131	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
591946012132	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
591946012133	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
591946012134	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
591946012135	active site
591946012136	intersubunit interface [polypeptide binding]; other site
591946012137	catalytic residue [active]
591946012138	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
591946012139	Transcriptional regulator [Transcription]; Region: IclR; COG1414
591946012140	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
591946012141	Bacterial transcriptional regulator; Region: IclR; pfam01614
591946012142	DNA recombination protein RmuC; Provisional; Region: PRK10361
591946012143	RmuC family; Region: RmuC; pfam02646
591946012144	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
591946012145	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946012146	S-adenosylmethionine binding site [chemical binding]; other site
591946012147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
591946012148	SCP-2 sterol transfer family; Region: SCP2; pfam02036
591946012149	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
591946012150	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
591946012151	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
591946012152	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
591946012153	sec-independent translocase; Provisional; Region: PRK01770
591946012154	sec-independent translocase; Provisional; Region: tatB; PRK00404
591946012155	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
591946012156	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
591946012157	active site
591946012158	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
591946012159	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
591946012160	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
591946012161	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
591946012162	FMN reductase; Validated; Region: fre; PRK08051
591946012163	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
591946012164	FAD binding pocket [chemical binding]; other site
591946012165	FAD binding motif [chemical binding]; other site
591946012166	phosphate binding motif [ion binding]; other site
591946012167	beta-alpha-beta structure motif; other site
591946012168	NAD binding pocket [chemical binding]; other site
591946012169	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
591946012170	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
591946012171	dimer interface [polypeptide binding]; other site
591946012172	active site
591946012173	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
591946012174	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
591946012175	substrate binding site [chemical binding]; other site
591946012176	oxyanion hole (OAH) forming residues; other site
591946012177	trimer interface [polypeptide binding]; other site
591946012178	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
591946012179	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
591946012180	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
591946012181	proline dipeptidase; Provisional; Region: PRK13607
591946012182	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
591946012183	active site
591946012184	hypothetical protein; Provisional; Region: PRK11568
591946012185	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
591946012186	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
591946012187	potassium transporter; Provisional; Region: PRK10750
591946012188	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
591946012189	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
591946012190	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
591946012191	Walker A motif; other site
591946012192	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
591946012193	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
591946012194	GTP binding site; other site
591946012195	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
591946012196	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
591946012197	serine/threonine protein kinase; Provisional; Region: PRK11768
591946012198	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
591946012199	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
591946012200	catalytic residues [active]
591946012201	hinge region; other site
591946012202	alpha helical domain; other site
591946012203	hypothetical protein; Provisional; Region: PRK11367
591946012204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
591946012205	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
591946012206	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
591946012207	putative acyl-acceptor binding pocket; other site
591946012208	DNA polymerase I; Provisional; Region: PRK05755
591946012209	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
591946012210	active site
591946012211	metal binding site 1 [ion binding]; metal-binding site
591946012212	putative 5' ssDNA interaction site; other site
591946012213	metal binding site 3; metal-binding site
591946012214	metal binding site 2 [ion binding]; metal-binding site
591946012215	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
591946012216	putative DNA binding site [nucleotide binding]; other site
591946012217	putative metal binding site [ion binding]; other site
591946012218	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
591946012219	active site
591946012220	catalytic site [active]
591946012221	substrate binding site [chemical binding]; other site
591946012222	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
591946012223	active site
591946012224	DNA binding site [nucleotide binding]
591946012225	catalytic site [active]
591946012226	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
591946012227	G1 box; other site
591946012228	GTP/Mg2+ binding site [chemical binding]; other site
591946012229	Switch I region; other site
591946012230	G2 box; other site
591946012231	G3 box; other site
591946012232	Switch II region; other site
591946012233	G4 box; other site
591946012234	G5 box; other site
591946012235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078
591946012236	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
591946012237	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946012238	FeS/SAM binding site; other site
591946012239	HemN C-terminal domain; Region: HemN_C; pfam06969
591946012240	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
591946012241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946012242	active site
591946012243	phosphorylation site [posttranslational modification]
591946012244	intermolecular recognition site; other site
591946012245	dimerization interface [polypeptide binding]; other site
591946012246	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946012247	Walker A motif; other site
591946012248	ATP binding site [chemical binding]; other site
591946012249	Walker B motif; other site
591946012250	arginine finger; other site
591946012251	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
591946012252	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
591946012253	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591946012254	putative active site [active]
591946012255	heme pocket [chemical binding]; other site
591946012256	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946012257	dimer interface [polypeptide binding]; other site
591946012258	phosphorylation site [posttranslational modification]
591946012259	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946012260	ATP binding site [chemical binding]; other site
591946012261	Mg2+ binding site [ion binding]; other site
591946012262	G-X-G motif; other site
591946012263	glutamine synthetase; Provisional; Region: glnA; PRK09469
591946012264	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
591946012265	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
591946012266	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
591946012267	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
591946012268	G1 box; other site
591946012269	putative GEF interaction site [polypeptide binding]; other site
591946012270	GTP/Mg2+ binding site [chemical binding]; other site
591946012271	Switch I region; other site
591946012272	G2 box; other site
591946012273	G3 box; other site
591946012274	Switch II region; other site
591946012275	G4 box; other site
591946012276	G5 box; other site
591946012277	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
591946012278	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
591946012279	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
591946012280	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946012281	active site
591946012282	motif I; other site
591946012283	motif II; other site
591946012284	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
591946012285	coproporphyrinogen III oxidase; Validated; Region: PRK08208
591946012286	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946012287	FeS/SAM binding site; other site
591946012288	HemN C-terminal domain; Region: HemN_C; pfam06969
591946012289	Sulfatase; Region: Sulfatase; cl17466
591946012290	ATP-grasp domain; Region: ATP-grasp_4; cl17255
591946012291	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591946012292	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
591946012293	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946012294	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591946012295	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
591946012296	substrate binding site [chemical binding]; other site
591946012297	ATP binding site [chemical binding]; other site
591946012298	NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461
591946012299	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
591946012300	Class I aldolases; Region: Aldolase_Class_I; cl17187
591946012301	catalytic residue [active]
591946012302	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
591946012303	putative oxidoreductase; Provisional; Region: PRK10083
591946012304	NAD(P) binding site [chemical binding]; other site
591946012305	benzoate transport; Region: 2A0115; TIGR00895
591946012306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946012307	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946012308	shikimate transporter; Provisional; Region: PRK09952
591946012309	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946012310	putative substrate translocation pore; other site
591946012311	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
591946012312	active site
591946012313	catalytic residues [active]
591946012314	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
591946012315	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946012316	motif II; other site
591946012317	hypothetical protein; Reviewed; Region: PRK01637
591946012318	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
591946012319	putative active site [active]
591946012320	dimerization interface [polypeptide binding]; other site
591946012321	putative tRNAtyr binding site [nucleotide binding]; other site
591946012322	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946012323	Coenzyme A binding pocket [chemical binding]; other site
591946012324	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
591946012325	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
591946012326	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
591946012327	substrate binding pocket [chemical binding]; other site
591946012328	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946012329	non-specific DNA binding site [nucleotide binding]; other site
591946012330	salt bridge; other site
591946012331	sequence-specific DNA binding site [nucleotide binding]; other site
591946012332	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
591946012333	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
591946012334	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
591946012335	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
591946012336	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
591946012337	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
591946012338	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
591946012339	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
591946012340	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
591946012341	[4Fe-4S] binding site [ion binding]; other site
591946012342	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
591946012343	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
591946012344	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
591946012345	molybdopterin cofactor binding site; other site
591946012346	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
591946012347	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
591946012348	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
591946012349	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
591946012350	intersubunit interface [polypeptide binding]; other site
591946012351	active site
591946012352	Zn2+ binding site [ion binding]; other site
591946012353	L-rhamnose isomerase; Provisional; Region: PRK01076
591946012354	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
591946012355	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
591946012356	N- and C-terminal domain interface [polypeptide binding]; other site
591946012357	active site
591946012358	putative catalytic site [active]
591946012359	metal binding site [ion binding]; metal-binding site
591946012360	ATP binding site [chemical binding]; other site
591946012361	rhamnulokinase; Provisional; Region: rhaB; PRK10640
591946012362	carbohydrate binding site [chemical binding]; other site
591946012363	transcriptional activator RhaS; Provisional; Region: PRK13503
591946012364	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
591946012365	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946012366	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946012367	transcriptional activator RhaR; Provisional; Region: PRK13500
591946012368	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
591946012369	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946012370	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946012371	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
591946012372	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
591946012373	superoxide dismutase; Provisional; Region: PRK10925
591946012374	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
591946012375	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
591946012376	2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793
591946012377	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
591946012378	MOSC domain; Region: MOSC; pfam03473
591946012379	3-alpha domain; Region: 3-alpha; pfam03475
591946012380	two-component sensor protein; Provisional; Region: cpxA; PRK09470
591946012381	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591946012382	dimerization interface [polypeptide binding]; other site
591946012383	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946012384	dimer interface [polypeptide binding]; other site
591946012385	phosphorylation site [posttranslational modification]
591946012386	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946012387	ATP binding site [chemical binding]; other site
591946012388	Mg2+ binding site [ion binding]; other site
591946012389	G-X-G motif; other site
591946012390	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
591946012391	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946012392	active site
591946012393	intermolecular recognition site; other site
591946012394	dimerization interface [polypeptide binding]; other site
591946012395	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946012396	DNA binding site [nucleotide binding]
591946012397	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
591946012398	dimer interface [polypeptide binding]; other site
591946012399	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
591946012400	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
591946012401	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
591946012402	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
591946012403	active site
591946012404	ADP/pyrophosphate binding site [chemical binding]; other site
591946012405	dimerization interface [polypeptide binding]; other site
591946012406	allosteric effector site; other site
591946012407	fructose-1,6-bisphosphate binding site; other site
591946012408	sulfate transporter subunit; Provisional; Region: PRK10752
591946012409	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
591946012410	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
591946012411	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
591946012412	triosephosphate isomerase; Provisional; Region: PRK14567
591946012413	substrate binding site [chemical binding]; other site
591946012414	dimer interface [polypeptide binding]; other site
591946012415	catalytic triad [active]
591946012416	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
591946012417	Predicted membrane protein [Function unknown]; Region: COG3152
591946012418	hypothetical protein; Provisional; Region: PRK09981
591946012419	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591946012420	Ligand Binding Site [chemical binding]; other site
591946012421	ferredoxin-NADP reductase; Provisional; Region: PRK10926
591946012422	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
591946012423	FAD binding pocket [chemical binding]; other site
591946012424	FAD binding motif [chemical binding]; other site
591946012425	phosphate binding motif [ion binding]; other site
591946012426	beta-alpha-beta structure motif; other site
591946012427	NAD binding pocket [chemical binding]; other site
591946012428	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
591946012429	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
591946012430	putative active site [active]
591946012431	glycerol kinase; Provisional; Region: glpK; PRK00047
591946012432	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
591946012433	N- and C-terminal domain interface [polypeptide binding]; other site
591946012434	active site
591946012435	MgATP binding site [chemical binding]; other site
591946012436	catalytic site [active]
591946012437	metal binding site [ion binding]; metal-binding site
591946012438	glycerol binding site [chemical binding]; other site
591946012439	homotetramer interface [polypeptide binding]; other site
591946012440	homodimer interface [polypeptide binding]; other site
591946012441	FBP binding site [chemical binding]; other site
591946012442	protein IIAGlc interface [polypeptide binding]; other site
591946012443	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
591946012444	amphipathic channel; other site
591946012445	Asn-Pro-Ala signature motifs; other site
591946012446	septal ring assembly protein ZapB; Provisional; Region: PRK15422
591946012447	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
591946012448	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
591946012449	UbiA prenyltransferase family; Region: UbiA; pfam01040
591946012450	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
591946012451	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946012452	Walker A motif; other site
591946012453	ATP binding site [chemical binding]; other site
591946012454	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
591946012455	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
591946012456	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
591946012457	active site
591946012458	HslU subunit interaction site [polypeptide binding]; other site
591946012459	essential cell division protein FtsN; Provisional; Region: PRK10927
591946012460	cell division protein FtsN; Provisional; Region: PRK12757
591946012461	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946012462	DNA binding site [nucleotide binding]
591946012463	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
591946012464	domain linker motif; other site
591946012465	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
591946012466	dimerization interface [polypeptide binding]; other site
591946012467	ligand binding site [chemical binding]; other site
591946012468	primosome assembly protein PriA; Validated; Region: PRK05580
591946012469	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591946012470	ATP binding site [chemical binding]; other site
591946012471	putative Mg++ binding site [ion binding]; other site
591946012472	helicase superfamily c-terminal domain; Region: HELICc; smart00490
591946012473	ATP-binding site [chemical binding]; other site
591946012474	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
591946012475	hypothetical protein; Provisional; Region: PRK10030
591946012476	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
591946012477	dimerization interface [polypeptide binding]; other site
591946012478	DNA binding site [nucleotide binding]
591946012479	corepressor binding sites; other site
591946012480	cystathionine gamma-synthase; Provisional; Region: PRK08045
591946012481	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
591946012482	homodimer interface [polypeptide binding]; other site
591946012483	substrate-cofactor binding pocket; other site
591946012484	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946012485	catalytic residue [active]
591946012486	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
591946012487	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
591946012488	putative catalytic residues [active]
591946012489	putative nucleotide binding site [chemical binding]; other site
591946012490	putative aspartate binding site [chemical binding]; other site
591946012491	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
591946012492	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
591946012493	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
591946012494	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
591946012495	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
591946012496	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
591946012497	active site
591946012498	metal binding site [ion binding]; metal-binding site
591946012499	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
591946012500	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
591946012501	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
591946012502	active site
591946012503	metal binding site [ion binding]; metal-binding site
591946012504	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
591946012505	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
591946012506	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
591946012507	active site
591946012508	metal binding site [ion binding]; metal-binding site
591946012509	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
591946012510	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
591946012511	FAD binding site [chemical binding]; other site
591946012512	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
591946012513	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
591946012514	heme binding site [chemical binding]; other site
591946012515	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
591946012516	EamA-like transporter family; Region: EamA; pfam00892
591946012517	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
591946012518	EamA-like transporter family; Region: EamA; pfam00892
591946012519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738
591946012520	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
591946012521	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
591946012522	dimer interface [polypeptide binding]; other site
591946012523	active site
591946012524	metal binding site [ion binding]; metal-binding site
591946012525	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
591946012526	active site
591946012527	intersubunit interactions; other site
591946012528	catalytic residue [active]
591946012529	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
591946012530	dimerization domain swap beta strand [polypeptide binding]; other site
591946012531	regulatory protein interface [polypeptide binding]; other site
591946012532	active site
591946012533	regulatory phosphorylation site [posttranslational modification]; other site
591946012534	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
591946012535	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
591946012536	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591946012537	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
591946012538	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591946012539	active site
591946012540	phosphorylation site [posttranslational modification]
591946012541	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
591946012542	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
591946012543	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
591946012544	active site
591946012545	P-loop; other site
591946012546	phosphorylation site [posttranslational modification]
591946012547	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
591946012548	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
591946012549	dimer interface [polypeptide binding]; other site
591946012550	active site
591946012551	glycine loop; other site
591946012552	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
591946012553	FeS/SAM binding site; other site
591946012554	pyruvate formate lyase II activase; Provisional; Region: PRK10076
591946012555	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
591946012556	active site
591946012557	P-loop; other site
591946012558	phosphorylation site [posttranslational modification]
591946012559	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591946012560	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946012561	hypothetical protein; Provisional; Region: PRK10649
591946012562	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
591946012563	Sulfatase; Region: Sulfatase; pfam00884
591946012564	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
591946012565	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
591946012566	acetylornithine deacetylase; Provisional; Region: PRK05111
591946012567	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
591946012568	metal binding site [ion binding]; metal-binding site
591946012569	putative dimer interface [polypeptide binding]; other site
591946012570	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
591946012571	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
591946012572	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
591946012573	nucleotide binding site [chemical binding]; other site
591946012574	N-acetyl-L-glutamate binding site [chemical binding]; other site
591946012575	argininosuccinate lyase; Provisional; Region: PRK04833
591946012576	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
591946012577	active sites [active]
591946012578	tetramer interface [polypeptide binding]; other site
591946012579	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
591946012580	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
591946012581	putative active site pocket [active]
591946012582	putative metal binding site [ion binding]; other site
591946012583	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946012584	D-galactonate transporter; Region: 2A0114; TIGR00893
591946012585	putative substrate translocation pore; other site
591946012586	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
591946012587	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946012588	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
591946012589	dimerization interface [polypeptide binding]; other site
591946012590	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
591946012591	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946012592	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
591946012593	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
591946012594	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
591946012595	metal binding site [ion binding]; metal-binding site
591946012596	putative dimer interface [polypeptide binding]; other site
591946012597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946012598	metabolite-proton symporter; Region: 2A0106; TIGR00883
591946012599	putative substrate translocation pore; other site
591946012600	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
591946012601	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591946012602	hypothetical protein; Provisional; Region: PRK11056
591946012603	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
591946012604	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946012605	S-adenosylmethionine binding site [chemical binding]; other site
591946012606	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
591946012607	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591946012608	N-terminal plug; other site
591946012609	ligand-binding site [chemical binding]; other site
591946012610	glutamate racemase; Provisional; Region: PRK00865
591946012611	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
591946012612	FAD binding domain; Region: FAD_binding_4; pfam01565
591946012613	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
591946012614	Biotin operon repressor [Transcription]; Region: BirA; COG1654
591946012615	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
591946012616	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
591946012617	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
591946012618	pantothenate kinase; Provisional; Region: PRK05439
591946012619	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
591946012620	ATP-binding site [chemical binding]; other site
591946012621	CoA-binding site [chemical binding]; other site
591946012622	Mg2+-binding site [ion binding]; other site
591946012623	elongation factor Tu; Reviewed; Region: PRK00049
591946012624	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
591946012625	G1 box; other site
591946012626	GEF interaction site [polypeptide binding]; other site
591946012627	GTP/Mg2+ binding site [chemical binding]; other site
591946012628	Switch I region; other site
591946012629	G2 box; other site
591946012630	G3 box; other site
591946012631	Switch II region; other site
591946012632	G4 box; other site
591946012633	G5 box; other site
591946012634	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
591946012635	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
591946012636	Antibiotic Binding Site [chemical binding]; other site
591946012637	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
591946012638	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
591946012639	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
591946012640	putative homodimer interface [polypeptide binding]; other site
591946012641	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
591946012642	heterodimer interface [polypeptide binding]; other site
591946012643	homodimer interface [polypeptide binding]; other site
591946012644	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
591946012645	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
591946012646	23S rRNA interface [nucleotide binding]; other site
591946012647	L7/L12 interface [polypeptide binding]; other site
591946012648	putative thiostrepton binding site; other site
591946012649	L25 interface [polypeptide binding]; other site
591946012650	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
591946012651	mRNA/rRNA interface [nucleotide binding]; other site
591946012652	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
591946012653	23S rRNA interface [nucleotide binding]; other site
591946012654	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
591946012655	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
591946012656	core dimer interface [polypeptide binding]; other site
591946012657	peripheral dimer interface [polypeptide binding]; other site
591946012658	L10 interface [polypeptide binding]; other site
591946012659	L11 interface [polypeptide binding]; other site
591946012660	putative EF-Tu interaction site [polypeptide binding]; other site
591946012661	putative EF-G interaction site [polypeptide binding]; other site
591946012662	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
591946012663	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
591946012664	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
591946012665	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
591946012666	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
591946012667	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
591946012668	RPB3 interaction site [polypeptide binding]; other site
591946012669	RPB1 interaction site [polypeptide binding]; other site
591946012670	RPB11 interaction site [polypeptide binding]; other site
591946012671	RPB10 interaction site [polypeptide binding]; other site
591946012672	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
591946012673	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
591946012674	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
591946012675	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
591946012676	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
591946012677	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
591946012678	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
591946012679	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
591946012680	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
591946012681	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
591946012682	DNA binding site [nucleotide binding]
591946012683	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
591946012684	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
591946012685	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946012686	FeS/SAM binding site; other site
591946012687	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
591946012688	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
591946012689	ThiS interaction site; other site
591946012690	putative active site [active]
591946012691	tetramer interface [polypeptide binding]; other site
591946012692	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
591946012693	thiS-thiF/thiG interaction site; other site
591946012694	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
591946012695	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
591946012696	ATP binding site [chemical binding]; other site
591946012697	substrate interface [chemical binding]; other site
591946012698	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
591946012699	thiamine phosphate binding site [chemical binding]; other site
591946012700	active site
591946012701	pyrophosphate binding site [ion binding]; other site
591946012702	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
591946012703	ThiC-associated domain; Region: ThiC-associated; pfam13667
591946012704	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
591946012705	Regulator of sigma D [Transcription]; Region: Rsd; COG3160
591946012706	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
591946012707	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
591946012708	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
591946012709	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
591946012710	putative NADH binding site [chemical binding]; other site
591946012711	putative active site [active]
591946012712	nudix motif; other site
591946012713	putative metal binding site [ion binding]; other site
591946012714	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
591946012715	substrate binding site [chemical binding]; other site
591946012716	active site
591946012717	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
591946012718	Active_site [active]
591946012719	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
591946012720	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
591946012721	IHF dimer interface [polypeptide binding]; other site
591946012722	IHF - DNA interface [nucleotide binding]; other site
591946012723	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
591946012724	zinc resistance protein; Provisional; Region: zraP; PRK11546
591946012725	dimer interface [polypeptide binding]; other site
591946012726	sensor protein ZraS; Provisional; Region: PRK10364
591946012727	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946012728	dimer interface [polypeptide binding]; other site
591946012729	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946012730	ATP binding site [chemical binding]; other site
591946012731	Mg2+ binding site [ion binding]; other site
591946012732	G-X-G motif; other site
591946012733	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
591946012734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946012735	active site
591946012736	phosphorylation site [posttranslational modification]
591946012737	intermolecular recognition site; other site
591946012738	dimerization interface [polypeptide binding]; other site
591946012739	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946012740	Walker A motif; other site
591946012741	ATP binding site [chemical binding]; other site
591946012742	Walker B motif; other site
591946012743	arginine finger; other site
591946012744	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
591946012745	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
591946012746	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
591946012747	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
591946012748	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
591946012749	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
591946012750	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
591946012751	purine monophosphate binding site [chemical binding]; other site
591946012752	dimer interface [polypeptide binding]; other site
591946012753	putative catalytic residues [active]
591946012754	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
591946012755	hypothetical protein; Provisional; Region: PRK10039
591946012756	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
591946012757	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946012758	Coenzyme A binding pocket [chemical binding]; other site
591946012759	homoserine O-succinyltransferase; Provisional; Region: PRK05368
591946012760	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
591946012761	proposed active site lysine [active]
591946012762	conserved cys residue [active]
591946012763	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
591946012764	malate synthase A; Region: malate_syn_A; TIGR01344
591946012765	active site
591946012766	isocitrate lyase; Provisional; Region: PRK15063
591946012767	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
591946012768	tetramer interface [polypeptide binding]; other site
591946012769	active site
591946012770	Mg2+/Mn2+ binding site [ion binding]; other site
591946012771	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
591946012772	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
591946012773	transcriptional repressor IclR; Provisional; Region: PRK11569
591946012774	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
591946012775	Bacterial transcriptional regulator; Region: IclR; pfam01614
591946012776	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
591946012777	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
591946012778	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
591946012779	substrate binding pocket [chemical binding]; other site
591946012780	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
591946012781	B12 binding site [chemical binding]; other site
591946012782	cobalt ligand [ion binding]; other site
591946012783	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
591946012784	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
591946012785	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
591946012786	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
591946012787	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
591946012788	active site pocket [active]
591946012789	oxyanion hole [active]
591946012790	catalytic triad [active]
591946012791	active site nucleophile [active]
591946012792	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
591946012793	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591946012794	putative NAD(P) binding site [chemical binding]; other site
591946012795	catalytic Zn binding site [ion binding]; other site
591946012796	PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828
591946012797	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
591946012798	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
591946012799	active site
591946012800	phosphorylation site [posttranslational modification]
591946012801	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
591946012802	active pocket/dimerization site; other site
591946012803	active site
591946012804	phosphorylation site [posttranslational modification]
591946012805	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
591946012806	classical (c) SDRs; Region: SDR_c; cd05233
591946012807	NAD(P) binding site [chemical binding]; other site
591946012808	active site
591946012809	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
591946012810	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591946012811	putative DNA binding site [nucleotide binding]; other site
591946012812	putative Zn2+ binding site [ion binding]; other site
591946012813	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
591946012814	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
591946012815	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591946012816	RNA binding surface [nucleotide binding]; other site
591946012817	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
591946012818	probable active site [active]
591946012819	hypothetical protein; Provisional; Region: PRK10515
591946012820	aspartate kinase III; Validated; Region: PRK09084
591946012821	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
591946012822	nucleotide binding site [chemical binding]; other site
591946012823	substrate binding site [chemical binding]; other site
591946012824	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932
591946012825	lysine allosteric regulatory site; other site
591946012826	dimer interface [polypeptide binding]; other site
591946012827	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
591946012828	dimer interface [polypeptide binding]; other site
591946012829	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
591946012830	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
591946012831	active site
591946012832	dimer interface [polypeptide binding]; other site
591946012833	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
591946012834	dimer interface [polypeptide binding]; other site
591946012835	active site
591946012836	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
591946012837	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
591946012838	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
591946012839	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
591946012840	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
591946012841	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
591946012842	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946012843	dimer interface [polypeptide binding]; other site
591946012844	conserved gate region; other site
591946012845	putative PBP binding loops; other site
591946012846	ABC-ATPase subunit interface; other site
591946012847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946012848	dimer interface [polypeptide binding]; other site
591946012849	conserved gate region; other site
591946012850	putative PBP binding loops; other site
591946012851	ABC-ATPase subunit interface; other site
591946012852	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
591946012853	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
591946012854	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
591946012855	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
591946012856	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
591946012857	Walker A/P-loop; other site
591946012858	ATP binding site [chemical binding]; other site
591946012859	Q-loop/lid; other site
591946012860	ABC transporter signature motif; other site
591946012861	Walker B; other site
591946012862	D-loop; other site
591946012863	H-loop/switch region; other site
591946012864	TOBE domain; Region: TOBE_2; pfam08402
591946012865	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
591946012866	trimer interface; other site
591946012867	sugar binding site [chemical binding]; other site
591946012868	maltose regulon periplasmic protein; Provisional; Region: PRK10564
591946012869	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
591946012870	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
591946012871	UbiA prenyltransferase family; Region: UbiA; pfam01040
591946012872	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
591946012873	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
591946012874	putative acyl-acceptor binding pocket; other site
591946012875	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
591946012876	LexA repressor; Validated; Region: PRK00215
591946012877	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
591946012878	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
591946012879	Catalytic site [active]
591946012880	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
591946012881	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
591946012882	hypothetical protein; Provisional; Region: PRK10428
591946012883	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
591946012884	metal binding site 2 [ion binding]; metal-binding site
591946012885	putative DNA binding helix; other site
591946012886	metal binding site 1 [ion binding]; metal-binding site
591946012887	dimer interface [polypeptide binding]; other site
591946012888	structural Zn2+ binding site [ion binding]; other site
591946012889	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
591946012890	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
591946012891	FMN binding site [chemical binding]; other site
591946012892	active site
591946012893	catalytic residues [active]
591946012894	substrate binding site [chemical binding]; other site
591946012895	phage shock protein G; Reviewed; Region: pspG; PRK09459
591946012896	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
591946012897	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
591946012898	NADP binding site [chemical binding]; other site
591946012899	dimer interface [polypeptide binding]; other site
591946012900	replicative DNA helicase; Provisional; Region: PRK08006
591946012901	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
591946012902	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
591946012903	Walker A motif; other site
591946012904	ATP binding site [chemical binding]; other site
591946012905	Walker B motif; other site
591946012906	DNA binding loops [nucleotide binding]
591946012907	alanine racemase; Reviewed; Region: alr; PRK00053
591946012908	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
591946012909	active site
591946012910	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591946012911	substrate binding site [chemical binding]; other site
591946012912	catalytic residues [active]
591946012913	dimer interface [polypeptide binding]; other site
591946012914	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
591946012915	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591946012916	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946012917	homodimer interface [polypeptide binding]; other site
591946012918	catalytic residue [active]
591946012919	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
591946012920	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
591946012921	TPP-binding site [chemical binding]; other site
591946012922	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
591946012923	dimer interface [polypeptide binding]; other site
591946012924	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
591946012925	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
591946012926	E3 interaction surface; other site
591946012927	lipoyl attachment site [posttranslational modification]; other site
591946012928	e3 binding domain; Region: E3_binding; pfam02817
591946012929	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
591946012930	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
591946012931	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
591946012932	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591946012933	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
591946012934	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
591946012935	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
591946012936	CoA-ligase; Region: Ligase_CoA; pfam00549
591946012937	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
591946012938	CoA binding domain; Region: CoA_binding; smart00881
591946012939	CoA-ligase; Region: Ligase_CoA; pfam00549
591946012940	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
591946012941	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
591946012942	transmembrane helices; other site
591946012943	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
591946012944	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
591946012945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946012946	active site
591946012947	phosphorylation site [posttranslational modification]
591946012948	intermolecular recognition site; other site
591946012949	dimerization interface [polypeptide binding]; other site
591946012950	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946012951	Walker A motif; other site
591946012952	ATP binding site [chemical binding]; other site
591946012953	Walker B motif; other site
591946012954	arginine finger; other site
591946012955	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
591946012956	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
591946012957	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946012958	dimer interface [polypeptide binding]; other site
591946012959	phosphorylation site [posttranslational modification]
591946012960	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946012961	ATP binding site [chemical binding]; other site
591946012962	Mg2+ binding site [ion binding]; other site
591946012963	G-X-G motif; other site
591946012964	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946012965	active site
591946012966	motif I; other site
591946012967	motif II; other site
591946012968	secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ
591946012969	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
591946012970	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
591946012971	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
591946012972	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
591946012973	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
591946012974	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
591946012975	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
591946012976	dimer interface [polypeptide binding]; other site
591946012977	ssDNA binding site [nucleotide binding]; other site
591946012978	tetramer (dimer of dimers) interface [polypeptide binding]; other site
591946012979	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
591946012980	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
591946012981	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
591946012982	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591946012983	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
591946012984	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946012985	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
591946012986	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
591946012987	DNA binding residues [nucleotide binding]
591946012988	dimer interface [polypeptide binding]; other site
591946012989	[2Fe-2S] cluster binding site [ion binding]; other site
591946012990	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
591946012991	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
591946012992	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
591946012993	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591946012994	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946012995	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
591946012996	putative dimerization interface [polypeptide binding]; other site
591946012997	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
591946012998	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
591946012999	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
591946013000	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
591946013001	Na binding site [ion binding]; other site
591946013002	Predicted membrane protein [Function unknown]; Region: COG3162
591946013003	acetyl-CoA synthetase; Provisional; Region: PRK00174
591946013004	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
591946013005	active site
591946013006	CoA binding site [chemical binding]; other site
591946013007	acyl-activating enzyme (AAE) consensus motif; other site
591946013008	AMP binding site [chemical binding]; other site
591946013009	acetate binding site [chemical binding]; other site
591946013010	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
591946013011	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
591946013012	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
591946013013	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
591946013014	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
591946013015	heme lyase subunit NrfE; Provisional; Region: PRK10369
591946013016	formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144
591946013017	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
591946013018	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591946013019	binding surface
591946013020	TPR motif; other site
591946013021	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
591946013022	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
591946013023	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
591946013024	Sel1-like repeats; Region: SEL1; smart00671
591946013025	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
591946013026	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946013027	Walker A/P-loop; other site
591946013028	ATP binding site [chemical binding]; other site
591946013029	Q-loop/lid; other site
591946013030	ABC transporter signature motif; other site
591946013031	Walker B; other site
591946013032	D-loop; other site
591946013033	H-loop/switch region; other site
591946013034	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
591946013035	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946013036	Walker A/P-loop; other site
591946013037	ATP binding site [chemical binding]; other site
591946013038	Q-loop/lid; other site
591946013039	ABC transporter signature motif; other site
591946013040	Walker B; other site
591946013041	D-loop; other site
591946013042	H-loop/switch region; other site
591946013043	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
591946013044	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
591946013045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946013046	dimer interface [polypeptide binding]; other site
591946013047	conserved gate region; other site
591946013048	ABC-ATPase subunit interface; other site
591946013049	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
591946013050	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946013051	dimer interface [polypeptide binding]; other site
591946013052	conserved gate region; other site
591946013053	putative PBP binding loops; other site
591946013054	ABC-ATPase subunit interface; other site
591946013055	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
591946013056	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
591946013057	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
591946013058	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
591946013059	[4Fe-4S] binding site [ion binding]; other site
591946013060	molybdopterin cofactor binding site; other site
591946013061	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
591946013062	molybdopterin cofactor binding site; other site
591946013063	putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915
591946013064	multidrug efflux system protein MdtO; Provisional; Region: PRK11427
591946013065	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
591946013066	multidrug resistance protein MdtN; Provisional; Region: PRK10476
591946013067	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591946013068	HlyD family secretion protein; Region: HlyD_3; pfam13437
591946013069	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
591946013070	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
591946013071	D-allose kinase; Provisional; Region: PRK09698
591946013072	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591946013073	nucleotide binding site [chemical binding]; other site
591946013074	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
591946013075	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
591946013076	substrate binding site [chemical binding]; other site
591946013077	hexamer interface [polypeptide binding]; other site
591946013078	metal binding site [ion binding]; metal-binding site
591946013079	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591946013080	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591946013081	TM-ABC transporter signature motif; other site
591946013082	D-allose transporter ATP-binding protein; Provisional; Region: PRK09700
591946013083	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946013084	Walker A/P-loop; other site
591946013085	ATP binding site [chemical binding]; other site
591946013086	Q-loop/lid; other site
591946013087	ABC transporter signature motif; other site
591946013088	Walker B; other site
591946013089	D-loop; other site
591946013090	H-loop/switch region; other site
591946013091	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591946013092	D-allose transporter subunit; Provisional; Region: PRK09701
591946013093	Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320
591946013094	ligand binding site [chemical binding]; other site
591946013095	dimerization interface [polypeptide binding]; other site
591946013096	zinc binding site [ion binding]; other site
591946013097	DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337
591946013098	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
591946013099	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
591946013100	putative active site [active]
591946013101	ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120
591946013102	carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244
591946013103	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946013104	Coenzyme A binding pocket [chemical binding]; other site
591946013105	ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078
591946013106	AAA domain; Region: AAA_18; pfam13238
591946013107	active site
591946013108	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
591946013109	Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454
591946013110	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
591946013111	active site
591946013112	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
591946013113	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591946013114	Walker A/P-loop; other site
591946013115	ATP binding site [chemical binding]; other site
591946013116	Q-loop/lid; other site
591946013117	ABC transporter signature motif; other site
591946013118	Walker B; other site
591946013119	D-loop; other site
591946013120	H-loop/switch region; other site
591946013121	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
591946013122	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591946013123	Walker A/P-loop; other site
591946013124	ATP binding site [chemical binding]; other site
591946013125	Q-loop/lid; other site
591946013126	ABC transporter signature motif; other site
591946013127	Walker B; other site
591946013128	D-loop; other site
591946013129	H-loop/switch region; other site
591946013130	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
591946013131	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627
591946013132	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626
591946013133	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625
591946013134	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
591946013135	phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079
591946013136	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946013137	DNA-binding site [nucleotide binding]; DNA binding site
591946013138	UTRA domain; Region: UTRA; pfam07702
591946013139	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
591946013140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591946013141	dimer interface [polypeptide binding]; other site
591946013142	conserved gate region; other site
591946013143	putative PBP binding loops; other site
591946013144	ABC-ATPase subunit interface; other site
591946013145	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
591946013146	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591946013147	substrate binding pocket [chemical binding]; other site
591946013148	membrane-bound complex binding site; other site
591946013149	hinge residues; other site
591946013150	phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984
591946013151	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
591946013152	Walker A/P-loop; other site
591946013153	ATP binding site [chemical binding]; other site
591946013154	Q-loop/lid; other site
591946013155	ABC transporter signature motif; other site
591946013156	Walker B; other site
591946013157	D-loop; other site
591946013158	H-loop/switch region; other site
591946013159	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
591946013160	dimer interface [polypeptide binding]; other site
591946013161	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
591946013162	hypothetical protein; Provisional; Region: PRK10220
591946013163	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
591946013164	PhnA protein; Region: PhnA; pfam03831
591946013165	hypothetical protein; Provisional; Region: PRK09866
591946013166	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
591946013167	G1 box; other site
591946013168	GTP/Mg2+ binding site [chemical binding]; other site
591946013169	G2 box; other site
591946013170	Switch I region; other site
591946013171	G3 box; other site
591946013172	Switch II region; other site
591946013173	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
591946013174	G2 box; other site
591946013175	Switch I region; other site
591946013176	G3 box; other site
591946013177	Switch II region; other site
591946013178	G4 box; other site
591946013179	G5 box; other site
591946013180	YjcZ-like protein; Region: YjcZ; pfam13990
591946013181	proline/glycine betaine transporter; Provisional; Region: PRK10642
591946013182	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946013183	putative substrate translocation pore; other site
591946013184	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
591946013185	sensor protein BasS/PmrB; Provisional; Region: PRK10755
591946013186	HAMP domain; Region: HAMP; pfam00672
591946013187	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946013188	dimer interface [polypeptide binding]; other site
591946013189	phosphorylation site [posttranslational modification]
591946013190	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946013191	ATP binding site [chemical binding]; other site
591946013192	Mg2+ binding site [ion binding]; other site
591946013193	G-X-G motif; other site
591946013194	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
591946013195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946013196	active site
591946013197	phosphorylation site [posttranslational modification]
591946013198	intermolecular recognition site; other site
591946013199	dimerization interface [polypeptide binding]; other site
591946013200	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946013201	DNA binding site [nucleotide binding]
591946013202	putative metal dependent hydrolase; Provisional; Region: PRK11598
591946013203	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
591946013204	Sulfatase; Region: Sulfatase; pfam00884
591946013205	arginine:agmatin antiporter; Provisional; Region: PRK10644
591946013206	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591946013207	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946013208	arginine decarboxylase; Provisional; Region: PRK15029
591946013209	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
591946013210	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
591946013211	homodimer interface [polypeptide binding]; other site
591946013212	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946013213	catalytic residue [active]
591946013214	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
591946013215	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
591946013216	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946013217	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946013218	alpha-galactosidase; Provisional; Region: PRK15076
591946013219	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
591946013220	NAD binding site [chemical binding]; other site
591946013221	sugar binding site [chemical binding]; other site
591946013222	divalent metal binding site [ion binding]; other site
591946013223	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
591946013224	dimer interface [polypeptide binding]; other site
591946013225	hypothetical protein; Provisional; Region: PRK09867
591946013226	fumarate hydratase; Provisional; Region: PRK15389
591946013227	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
591946013228	Fumarase C-terminus; Region: Fumerase_C; pfam05683
591946013229	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
591946013230	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
591946013231	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
591946013232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946013233	active site
591946013234	phosphorylation site [posttranslational modification]
591946013235	intermolecular recognition site; other site
591946013236	dimerization interface [polypeptide binding]; other site
591946013237	Transcriptional regulator; Region: CitT; pfam12431
591946013238	sensory histidine kinase DcuS; Provisional; Region: PRK11086
591946013239	PAS domain; Region: PAS; smart00091
591946013240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946013241	ATP binding site [chemical binding]; other site
591946013242	Mg2+ binding site [ion binding]; other site
591946013243	G-X-G motif; other site
591946013244	Uncharacterized conserved protein [Function unknown]; Region: COG3592
591946013245	Predicted acetyltransferase [General function prediction only]; Region: COG2388
591946013246	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
591946013247	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
591946013248	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
591946013249	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
591946013250	dimer interface [polypeptide binding]; other site
591946013251	putative anticodon binding site; other site
591946013252	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
591946013253	motif 1; other site
591946013254	active site
591946013255	motif 2; other site
591946013256	motif 3; other site
591946013257	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
591946013258	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946013259	putative substrate translocation pore; other site
591946013260	POT family; Region: PTR2; pfam00854
591946013261	lysine decarboxylase CadA; Provisional; Region: PRK15400
591946013262	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
591946013263	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
591946013264	homodimer interface [polypeptide binding]; other site
591946013265	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591946013266	catalytic residue [active]
591946013267	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
591946013268	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
591946013269	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
591946013270	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946013271	DNA binding site [nucleotide binding]
591946013272	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
591946013273	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
591946013274	P-loop; other site
591946013275	Magnesium ion binding site [ion binding]; other site
591946013276	replicative DNA helicase; Region: DnaB; TIGR00665
591946013277	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
591946013278	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
591946013279	Walker A motif; other site
591946013280	ATP binding site [chemical binding]; other site
591946013281	Walker B motif; other site
591946013282	DNA binding loops [nucleotide binding]
591946013283	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
591946013284	ParB-like nuclease domain; Region: ParB; smart00470
591946013285	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
591946013286	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
591946013287	Helix-turn-helix domain; Region: HTH_36; pfam13730
591946013288	Domain of unknown function (DUF1845); Region: DUF1845; pfam08900
591946013289	DNA topoisomerase III; Provisional; Region: PRK07726
591946013290	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
591946013291	active site
591946013292	putative interdomain interaction site [polypeptide binding]; other site
591946013293	putative metal-binding site [ion binding]; other site
591946013294	putative nucleotide binding site [chemical binding]; other site
591946013295	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
591946013296	domain I; other site
591946013297	DNA binding groove [nucleotide binding]
591946013298	phosphate binding site [ion binding]; other site
591946013299	domain II; other site
591946013300	domain III; other site
591946013301	nucleotide binding site [chemical binding]; other site
591946013302	catalytic site [active]
591946013303	domain IV; other site
591946013304	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
591946013305	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
591946013306	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
591946013307	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
591946013308	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
591946013309	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591946013310	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591946013311	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
591946013312	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
591946013313	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
591946013314	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
591946013315	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
591946013316	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
591946013317	P-loop; other site
591946013318	Magnesium ion binding site [ion binding]; other site
591946013319	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
591946013320	Magnesium ion binding site [ion binding]; other site
591946013321	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
591946013322	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
591946013323	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
591946013324	conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750
591946013325	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
591946013326	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
591946013327	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
591946013328	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
591946013329	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
591946013330	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
591946013331	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
591946013332	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
591946013333	active site
591946013334	Zn binding site [ion binding]; other site
591946013335	Protein of unknown function (DUF1525); Region: DUF1525; pfam07511
591946013336	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
591946013337	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
591946013338	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
591946013339	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591946013340	DNA-binding site [nucleotide binding]; DNA binding site
591946013341	RNA-binding motif; other site
591946013342	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
591946013343	Integrase; Region: Integrase_1; pfam12835
591946013344	Antirestriction protein; Region: Antirestrict; pfam03230
591946013345	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
591946013346	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
591946013347	Bacterial SH3 domain homologues; Region: SH3b; smart00287
591946013348	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
591946013349	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
591946013350	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
591946013351	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
591946013352	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
591946013353	active site
591946013354	catalytic residues [active]
591946013355	DNA binding site [nucleotide binding]
591946013356	Int/Topo IB signature motif; other site
591946013357	putative transcriptional regulator; Provisional; Region: PRK11640
591946013358	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591946013359	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
591946013360	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
591946013361	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
591946013362	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
591946013363	DsbD alpha interface [polypeptide binding]; other site
591946013364	catalytic residues [active]
591946013365	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
591946013366	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
591946013367	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
591946013368	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
591946013369	Aspartase; Region: Aspartase; cd01357
591946013370	active sites [active]
591946013371	tetramer interface [polypeptide binding]; other site
591946013372	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
591946013373	putative transporter; Provisional; Region: PRK11021
591946013374	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
591946013375	oligomerisation interface [polypeptide binding]; other site
591946013376	mobile loop; other site
591946013377	roof hairpin; other site
591946013378	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
591946013379	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
591946013380	ring oligomerisation interface [polypeptide binding]; other site
591946013381	ATP/Mg binding site [chemical binding]; other site
591946013382	stacking interactions; other site
591946013383	hinge regions; other site
591946013384	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
591946013385	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
591946013386	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946013387	FeS/SAM binding site; other site
591946013388	elongation factor P; Validated; Region: PRK00529
591946013389	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
591946013390	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
591946013391	RNA binding site [nucleotide binding]; other site
591946013392	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
591946013393	RNA binding site [nucleotide binding]; other site
591946013394	entericidin A; Provisional; Region: PRK09810
591946013395	entericidin B membrane lipoprotein; Provisional; Region: PRK10081
591946013396	multidrug efflux system protein; Provisional; Region: PRK11431
591946013397	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
591946013398	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
591946013399	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
591946013400	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
591946013401	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
591946013402	Iron-sulfur protein interface; other site
591946013403	proximal quinone binding site [chemical binding]; other site
591946013404	C-subunit interface; other site
591946013405	distal quinone binding site; other site
591946013406	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
591946013407	D-subunit interface [polypeptide binding]; other site
591946013408	Iron-sulfur protein interface; other site
591946013409	proximal quinone binding site [chemical binding]; other site
591946013410	distal quinone binding site [chemical binding]; other site
591946013411	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
591946013412	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
591946013413	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
591946013414	L-aspartate oxidase; Provisional; Region: PRK06175
591946013415	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
591946013416	poxB regulator PoxA; Provisional; Region: PRK09350
591946013417	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
591946013418	motif 1; other site
591946013419	dimer interface [polypeptide binding]; other site
591946013420	active site
591946013421	motif 2; other site
591946013422	motif 3; other site
591946013423	inner membrane transporter YjeM; Provisional; Region: PRK15238
591946013424	putative mechanosensitive channel protein; Provisional; Region: PRK10929
591946013425	linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073
591946013426	DNA-binding site [nucleotide binding]; DNA binding site
591946013427	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
591946013428	Mechanosensitive ion channel; Region: MS_channel; pfam00924
591946013429	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
591946013430	GTPase RsgA; Reviewed; Region: PRK12288
591946013431	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
591946013432	RNA binding site [nucleotide binding]; other site
591946013433	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
591946013434	GTPase/Zn-binding domain interface [polypeptide binding]; other site
591946013435	GTP/Mg2+ binding site [chemical binding]; other site
591946013436	G4 box; other site
591946013437	G5 box; other site
591946013438	G1 box; other site
591946013439	Switch I region; other site
591946013440	G2 box; other site
591946013441	G3 box; other site
591946013442	Switch II region; other site
591946013443	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
591946013444	catalytic site [active]
591946013445	putative active site [active]
591946013446	putative substrate binding site [chemical binding]; other site
591946013447	dimer interface [polypeptide binding]; other site
591946013448	epoxyqueuosine reductase; Region: TIGR00276
591946013449	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
591946013450	putative carbohydrate kinase; Provisional; Region: PRK10565
591946013451	yjeF N-terminal region; Region: yjeF_nterm; TIGR00197
591946013452	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
591946013453	putative substrate binding site [chemical binding]; other site
591946013454	putative ATP binding site [chemical binding]; other site
591946013455	ADP-binding protein; Provisional; Region: PRK10646
591946013456	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
591946013457	AMIN domain; Region: AMIN; pfam11741
591946013458	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
591946013459	active site
591946013460	metal binding site [ion binding]; metal-binding site
591946013461	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
591946013462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946013463	ATP binding site [chemical binding]; other site
591946013464	Mg2+ binding site [ion binding]; other site
591946013465	G-X-G motif; other site
591946013466	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
591946013467	ATP binding site [chemical binding]; other site
591946013468	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
591946013469	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
591946013470	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
591946013471	bacterial Hfq-like; Region: Hfq; cd01716
591946013472	hexamer interface [polypeptide binding]; other site
591946013473	Sm1 motif; other site
591946013474	RNA binding site [nucleotide binding]; other site
591946013475	Sm2 motif; other site
591946013476	GTPase HflX; Provisional; Region: PRK11058
591946013477	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
591946013478	HflX GTPase family; Region: HflX; cd01878
591946013479	G1 box; other site
591946013480	GTP/Mg2+ binding site [chemical binding]; other site
591946013481	Switch I region; other site
591946013482	G2 box; other site
591946013483	G3 box; other site
591946013484	Switch II region; other site
591946013485	G4 box; other site
591946013486	G5 box; other site
591946013487	FtsH protease regulator HflK; Provisional; Region: PRK10930
591946013488	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
591946013489	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
591946013490	FtsH protease regulator HflC; Provisional; Region: PRK11029
591946013491	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
591946013492	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
591946013493	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
591946013494	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
591946013495	GDP-binding site [chemical binding]; other site
591946013496	ACT binding site; other site
591946013497	IMP binding site; other site
591946013498	Predicted transcriptional regulator [Transcription]; Region: COG1959
591946013499	transcriptional repressor NsrR; Provisional; Region: PRK11014
591946013500	exoribonuclease R; Provisional; Region: PRK11642
591946013501	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
591946013502	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
591946013503	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
591946013504	RNB domain; Region: RNB; pfam00773
591946013505	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
591946013506	RNA binding site [nucleotide binding]; other site
591946013507	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
591946013508	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
591946013509	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
591946013510	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551
591946013511	PspA/IM30 family; Region: PspA_IM30; pfam04012
591946013512	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
591946013513	Predicted membrane protein [Function unknown]; Region: COG3766
591946013514	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
591946013515	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
591946013516	Predicted integral membrane protein [Function unknown]; Region: COG5463
591946013517	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
591946013518	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
591946013519	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
591946013520	FAD binding site [chemical binding]; other site
591946013521	substrate binding site [chemical binding]; other site
591946013522	catalytic residues [active]
591946013523	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591946013524	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
591946013525	esterase; Provisional; Region: PRK10566
591946013526	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
591946013527	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
591946013528	transcriptional repressor UlaR; Provisional; Region: PRK13509
591946013529	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
591946013530	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591946013531	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
591946013532	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
591946013533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
591946013534	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
591946013535	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
591946013536	active site
591946013537	P-loop; other site
591946013538	phosphorylation site [posttranslational modification]
591946013539	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591946013540	active site
591946013541	phosphorylation site [posttranslational modification]
591946013542	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
591946013543	active site
591946013544	dimer interface [polypeptide binding]; other site
591946013545	magnesium binding site [ion binding]; other site
591946013546	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
591946013547	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
591946013548	AP (apurinic/apyrimidinic) site pocket; other site
591946013549	DNA interaction; other site
591946013550	Metal-binding active site; metal-binding site
591946013551	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
591946013552	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
591946013553	intersubunit interface [polypeptide binding]; other site
591946013554	active site
591946013555	Zn2+ binding site [ion binding]; other site
591946013556	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591946013557	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
591946013558	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
591946013559	dimer interface [polypeptide binding]; other site
591946013560	ssDNA binding site [nucleotide binding]; other site
591946013561	tetramer (dimer of dimers) interface [polypeptide binding]; other site
591946013562	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
591946013563	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
591946013564	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
591946013565	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
591946013566	Helix-turn-helix domain; Region: HTH_31; pfam13560
591946013567	sequence-specific DNA binding site [nucleotide binding]; other site
591946013568	salt bridge; other site
591946013569	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
591946013570	HipA-like N-terminal domain; Region: HipA_N; pfam07805
591946013571	HipA-like C-terminal domain; Region: HipA_C; pfam07804
591946013572	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946013573	D-galactonate transporter; Region: 2A0114; TIGR00893
591946013574	putative substrate translocation pore; other site
591946013575	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
591946013576	L-aspartate oxidase; Provisional; Region: PRK06175
591946013577	L-aspartate oxidase; Provisional; Region: PRK06175
591946013578	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
591946013579	Coenzyme A transferase; Region: CoA_trans; smart00882
591946013580	Coenzyme A transferase; Region: CoA_trans; cl17247
591946013581	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
591946013582	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
591946013583	substrate binding site [chemical binding]; other site
591946013584	oxyanion hole (OAH) forming residues; other site
591946013585	trimer interface [polypeptide binding]; other site
591946013586	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
591946013587	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
591946013588	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337
591946013589	putative NAD(P) binding site [chemical binding]; other site
591946013590	active site
591946013591	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
591946013592	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
591946013593	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
591946013594	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
591946013595	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
591946013596	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
591946013597	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
591946013598	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
591946013599	Hemerythrin-like domain; Region: Hr-like; cd12108
591946013600	Fe binding site [ion binding]; other site
591946013601	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
591946013602	EamA-like transporter family; Region: EamA; pfam00892
591946013603	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
591946013604	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
591946013605	NADP binding site [chemical binding]; other site
591946013606	Predicted transcriptional regulators [Transcription]; Region: COG1733
591946013607	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
591946013608	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
591946013609	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
591946013610	active site
591946013611	metal binding site [ion binding]; metal-binding site
591946013612	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
591946013613	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
591946013614	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
591946013615	active site
591946013616	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
591946013617	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
591946013618	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
591946013619	Domain of unknown function DUF21; Region: DUF21; pfam01595
591946013620	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
591946013621	Transporter associated domain; Region: CorC_HlyC; smart01091
591946013622	methionine sulfoxide reductase A; Provisional; Region: PRK00058
591946013623	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
591946013624	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
591946013625	Surface antigen; Region: Bac_surface_Ag; pfam01103
591946013626	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
591946013627	Family of unknown function (DUF490); Region: DUF490; pfam04357
591946013628	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
591946013629	putative active site pocket [active]
591946013630	dimerization interface [polypeptide binding]; other site
591946013631	putative catalytic residue [active]
591946013632	Sel1-like repeats; Region: SEL1; smart00671
591946013633	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
591946013634	Sel1-like repeats; Region: SEL1; smart00671
591946013635	Sel1-like repeats; Region: SEL1; smart00671
591946013636	Sel1-like repeats; Region: SEL1; smart00671
591946013637	Sel1-like repeats; Region: SEL1; smart00671
591946013638	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
591946013639	Sel1-like repeats; Region: SEL1; smart00671
591946013640	Sel1-like repeats; Region: SEL1; smart00671
591946013641	Sel1-like repeats; Region: SEL1; smart00671
591946013642	Sel1-like repeats; Region: SEL1; smart00671
591946013643	Sel1-like repeats; Region: SEL1; smart00671
591946013644	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
591946013645	dimer interface [polypeptide binding]; other site
591946013646	substrate binding site [chemical binding]; other site
591946013647	metal binding sites [ion binding]; metal-binding site
591946013648	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
591946013649	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
591946013650	putative ligand binding site [chemical binding]; other site
591946013651	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
591946013652	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591946013653	Walker A/P-loop; other site
591946013654	ATP binding site [chemical binding]; other site
591946013655	Q-loop/lid; other site
591946013656	ABC transporter signature motif; other site
591946013657	Walker B; other site
591946013658	D-loop; other site
591946013659	H-loop/switch region; other site
591946013660	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591946013661	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591946013662	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591946013663	TM-ABC transporter signature motif; other site
591946013664	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591946013665	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591946013666	TM-ABC transporter signature motif; other site
591946013667	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
591946013668	AMP binding site [chemical binding]; other site
591946013669	metal binding site [ion binding]; metal-binding site
591946013670	active site
591946013671	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
591946013672	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
591946013673	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591946013674	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591946013675	hypothetical protein; Provisional; Region: PRK05255
591946013676	peptidase PmbA; Provisional; Region: PRK11040
591946013677	cytochrome b562; Provisional; Region: PRK15058
591946013678	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
591946013679	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946013680	FeS/SAM binding site; other site
591946013681	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
591946013682	ATP cone domain; Region: ATP-cone; pfam03477
591946013683	Class III ribonucleotide reductase; Region: RNR_III; cd01675
591946013684	effector binding site; other site
591946013685	active site
591946013686	Zn binding site [ion binding]; other site
591946013687	glycine loop; other site
591946013688	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
591946013689	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
591946013690	Ca binding site [ion binding]; other site
591946013691	active site
591946013692	catalytic site [active]
591946013693	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
591946013694	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
591946013695	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591946013696	active site turn [active]
591946013697	phosphorylation site [posttranslational modification]
591946013698	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591946013699	trehalose repressor; Provisional; Region: treR; PRK09492
591946013700	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946013701	DNA binding site [nucleotide binding]
591946013702	domain linker motif; other site
591946013703	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
591946013704	dimerization interface [polypeptide binding]; other site
591946013705	ligand binding site [chemical binding]; other site
591946013706	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
591946013707	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
591946013708	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591946013709	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
591946013710	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946013711	motif II; other site
591946013712	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
591946013713	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
591946013714	homotrimer interaction site [polypeptide binding]; other site
591946013715	putative active site [active]
591946013716	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
591946013717	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
591946013718	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
591946013719	aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670
591946013720	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
591946013721	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
591946013722	PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052
591946013723	Arginine repressor [Transcription]; Region: ArgR; COG1438
591946013724	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
591946013725	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
591946013726	Predicted membrane protein [Function unknown]; Region: COG1288
591946013727	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
591946013728	ornithine carbamoyltransferase; Validated; Region: PRK02102
591946013729	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
591946013730	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
591946013731	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
591946013732	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
591946013733	putative substrate binding site [chemical binding]; other site
591946013734	nucleotide binding site [chemical binding]; other site
591946013735	nucleotide binding site [chemical binding]; other site
591946013736	homodimer interface [polypeptide binding]; other site
591946013737	arginine deiminase; Provisional; Region: PRK01388
591946013738	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
591946013739	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
591946013740	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
591946013741	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
591946013742	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076
591946013743	RNase E inhibitor protein; Provisional; Region: PRK11191
591946013744	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
591946013745	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946013746	Coenzyme A binding pocket [chemical binding]; other site
591946013747	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
591946013748	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
591946013749	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
591946013750	HIGH motif; other site
591946013751	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
591946013752	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
591946013753	active site
591946013754	KMSKS motif; other site
591946013755	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
591946013756	tRNA binding surface [nucleotide binding]; other site
591946013757	anticodon binding site; other site
591946013758	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
591946013759	DNA polymerase III subunit chi; Validated; Region: PRK05728
591946013760	multifunctional aminopeptidase A; Provisional; Region: PRK00913
591946013761	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
591946013762	interface (dimer of trimers) [polypeptide binding]; other site
591946013763	Substrate-binding/catalytic site; other site
591946013764	Zn-binding sites [ion binding]; other site
591946013765	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
591946013766	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
591946013767	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
591946013768	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
591946013769	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
591946013770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
591946013771	Walker A motif; other site
591946013772	ATP binding site [chemical binding]; other site
591946013773	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
591946013774	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591946013775	DNA binding site [nucleotide binding]
591946013776	domain linker motif; other site
591946013777	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
591946013778	putative dimerization interface [polypeptide binding]; other site
591946013779	putative ligand binding site [chemical binding]; other site
591946013780	fructuronate transporter; Provisional; Region: PRK10034; cl15264
591946013781	gluconate transporter; Region: gntP; TIGR00791
591946013782	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
591946013783	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
591946013784	NADP binding site [chemical binding]; other site
591946013785	homodimer interface [polypeptide binding]; other site
591946013786	active site
591946013787	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
591946013788	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
591946013789	putative NAD(P) binding site [chemical binding]; other site
591946013790	catalytic Zn binding site [ion binding]; other site
591946013791	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
591946013792	ATP-binding site [chemical binding]; other site
591946013793	Gluconate-6-phosphate binding site [chemical binding]; other site
591946013794	Shikimate kinase; Region: SKI; pfam01202
591946013795	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
591946013796	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
591946013797	putative NAD(P) binding site [chemical binding]; other site
591946013798	putative substrate binding site [chemical binding]; other site
591946013799	catalytic Zn binding site [ion binding]; other site
591946013800	structural Zn binding site [ion binding]; other site
591946013801	dimer interface [polypeptide binding]; other site
591946013802	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
591946013803	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270
591946013804	DNA methylase; Region: N6_N4_Mtase; pfam01555
591946013805	DNA methylase; Region: N6_N4_Mtase; cl17433
591946013806	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
591946013807	Domain of unknown function (DUF303); Region: DUF303; pfam03629
591946013808	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
591946013809	Kelch motif; Region: Kelch_1; pfam01344
591946013810	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
591946013811	FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197
591946013812	Int/Topo IB signature motif; other site
591946013813	FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197
591946013814	Int/Topo IB signature motif; other site
591946013815	Fimbrial protein; Region: Fimbrial; cl01416
591946013816	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591946013817	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
591946013818	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591946013819	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591946013820	outer membrane usher protein; Provisional; Region: PRK15193
591946013821	PapC N-terminal domain; Region: PapC_N; pfam13954
591946013822	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591946013823	PapC C-terminal domain; Region: PapC_C; pfam13953
591946013824	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591946013825	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591946013826	Mannose binding  domain of FimH and related proteins; Region: FimH_man-bind; cd10466
591946013827	mannosyl binding site [chemical binding]; other site
591946013828	Fimbrial protein; Region: Fimbrial; pfam00419
591946013829	mannonate dehydratase; Region: uxuA; TIGR00695
591946013830	mannonate dehydratase; Provisional; Region: PRK03906
591946013831	D-mannonate oxidoreductase; Provisional; Region: PRK15037
591946013832	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
591946013833	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
591946013834	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
591946013835	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946013836	DNA-binding site [nucleotide binding]; DNA binding site
591946013837	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591946013838	DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128
591946013839	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
591946013840	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
591946013841	active pocket/dimerization site; other site
591946013842	active site
591946013843	phosphorylation site [posttranslational modification]
591946013844	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
591946013845	dimerization domain swap beta strand [polypeptide binding]; other site
591946013846	regulatory protein interface [polypeptide binding]; other site
591946013847	active site
591946013848	regulatory phosphorylation site [posttranslational modification]; other site
591946013849	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
591946013850	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
591946013851	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591946013852	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
591946013853	dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005
591946013854	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468
591946013855	Dak1 domain; Region: Dak1; pfam02733
591946013856	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
591946013857	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
591946013858	dimer interface [polypeptide binding]; other site
591946013859	active site
591946013860	metal binding site [ion binding]; metal-binding site
591946013861	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591946013862	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591946013863	putative substrate translocation pore; other site
591946013864	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
591946013865	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591946013866	BCCT family transporter; Region: BCCT; pfam02028
591946013867	glycerate kinase; Region: TIGR00045
591946013868	tartronate semialdehyde reductase; Provisional; Region: PRK15059
591946013869	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
591946013870	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
591946013871	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
591946013872	Metal-binding active site; metal-binding site
591946013873	glyoxylate carboligase; Provisional; Region: PRK11269
591946013874	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
591946013875	PYR/PP interface [polypeptide binding]; other site
591946013876	dimer interface [polypeptide binding]; other site
591946013877	TPP binding site [chemical binding]; other site
591946013878	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591946013879	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
591946013880	TPP-binding site [chemical binding]; other site
591946013881	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
591946013882	GAF domain; Region: GAF; pfam01590
591946013883	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
591946013884	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946013885	Walker A motif; other site
591946013886	ATP binding site [chemical binding]; other site
591946013887	Walker B motif; other site
591946013888	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
591946013889	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
591946013890	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
591946013891	cell density-dependent motility repressor; Provisional; Region: PRK10082
591946013892	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591946013893	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
591946013894	Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308
591946013895	isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975
591946013896	dimer interface [polypeptide binding]; other site
591946013897	active site
591946013898	hypothetical protein; Provisional; Region: PRK10519
591946013899	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
591946013900	Nucleoside recognition; Region: Gate; pfam07670
591946013901	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
591946013902	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
591946013903	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
591946013904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
591946013905	SdiA-regulated; Region: SdiA-regulated; cd09971
591946013906	putative active site [active]
591946013907	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
591946013908	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
591946013909	CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241
591946013910	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
591946013911	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
591946013912	Predicted membrane protein [Function unknown]; Region: COG2733
591946013913	putative transposase; Provisional; Region: PRK09857
591946013914	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
591946013915	Uncharacterized conserved protein [Function unknown]; Region: COG1479
591946013916	Protein of unknown function DUF262; Region: DUF262; pfam03235
591946013917	Protein of unknown function DUF262; Region: DUF262; pfam03235
591946013918	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
591946013919	Uncharacterized conserved protein [Function unknown]; Region: COG3586
591946013920	endoribonuclease SymE; Provisional; Region: PRK13605
591946013921	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
591946013922	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
591946013923	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
591946013924	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
591946013925	HsdM N-terminal domain; Region: HsdM_N; pfam12161
591946013926	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
591946013927	Methyltransferase domain; Region: Methyltransf_26; pfam13659
591946013928	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
591946013929	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
591946013930	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591946013931	ATP binding site [chemical binding]; other site
591946013932	putative Mg++ binding site [ion binding]; other site
591946013933	Uncharacterized conserved protein [Function unknown]; Region: COG1479
591946013934	Protein of unknown function DUF262; Region: DUF262; pfam03235
591946013935	Protein of unknown function DUF262; Region: DUF262; pfam03235
591946013936	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
591946013937	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
591946013938	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
591946013939	P-loop, Walker A motif; other site
591946013940	Base recognition motif; other site
591946013941	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
591946013942	Uncharacterized small protein [Function unknown]; Region: COG2879
591946013943	carbon starvation protein A; Provisional; Region: PRK15015
591946013944	Carbon starvation protein CstA; Region: CstA; pfam02554
591946013945	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
591946013946	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
591946013947	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
591946013948	dimer interface [polypeptide binding]; other site
591946013949	ligand binding site [chemical binding]; other site
591946013950	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591946013951	dimerization interface [polypeptide binding]; other site
591946013952	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
591946013953	dimer interface [polypeptide binding]; other site
591946013954	putative CheW interface [polypeptide binding]; other site
591946013955	DctM-like transporters; Region: DctM; pfam06808
591946013956	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
591946013957	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
591946013958	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
591946013959	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
591946013960	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
591946013961	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
591946013962	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591946013963	DNA-binding site [nucleotide binding]; DNA binding site
591946013964	Transcriptional regulators [Transcription]; Region: GntR; COG1802
591946013965	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591946013966	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591946013967	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
591946013968	putative NAD(P) binding site [chemical binding]; other site
591946013969	catalytic Zn binding site [ion binding]; other site
591946013970	structural Zn binding site [ion binding]; other site
591946013971	phosphoglycerol transferase I; Provisional; Region: PRK03776
591946013972	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
591946013973	hypothetical protein; Provisional; Region: PRK11667
591946013974	DNA replication protein DnaC; Validated; Region: PRK07952
591946013975	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591946013976	Walker A motif; other site
591946013977	ATP binding site [chemical binding]; other site
591946013978	Walker B motif; other site
591946013979	primosomal protein DnaI; Provisional; Region: PRK02854
591946013980	hypothetical protein; Provisional; Region: PRK09917
591946013981	Uncharacterized conserved protein [Function unknown]; Region: COG2966
591946013982	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
591946013983	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
591946013984	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946013985	DNA binding residues [nucleotide binding]
591946013986	dimerization interface [polypeptide binding]; other site
591946013987	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
591946013988	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591946013989	DNA binding residues [nucleotide binding]
591946013990	dimerization interface [polypeptide binding]; other site
591946013991	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
591946013992	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
591946013993	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
591946013994	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
591946013995	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
591946013996	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
591946013997	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591946013998	S-adenosylmethionine binding site [chemical binding]; other site
591946013999	DNA polymerase III subunit psi; Validated; Region: PRK06856
591946014000	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
591946014001	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591946014002	Coenzyme A binding pocket [chemical binding]; other site
591946014003	dUMP phosphatase; Provisional; Region: PRK09449
591946014004	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946014005	motif II; other site
591946014006	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
591946014007	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
591946014008	G1 box; other site
591946014009	putative GEF interaction site [polypeptide binding]; other site
591946014010	GTP/Mg2+ binding site [chemical binding]; other site
591946014011	Switch I region; other site
591946014012	G2 box; other site
591946014013	G3 box; other site
591946014014	Switch II region; other site
591946014015	G4 box; other site
591946014016	G5 box; other site
591946014017	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
591946014018	periplasmic protein; Provisional; Region: PRK10568
591946014019	BON domain; Region: BON; pfam04972
591946014020	BON domain; Region: BON; pfam04972
591946014021	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
591946014022	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
591946014023	active site
591946014024	nucleophile elbow; other site
591946014025	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
591946014026	active site
591946014027	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
591946014028	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591946014029	FeS/SAM binding site; other site
591946014030	hypothetical protein; Provisional; Region: PRK10977
591946014031	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
591946014032	intersubunit interface [polypeptide binding]; other site
591946014033	active site
591946014034	catalytic residue [active]
591946014035	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
591946014036	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
591946014037	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
591946014038	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
591946014039	phosphopentomutase; Provisional; Region: PRK05362
591946014040	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
591946014041	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
591946014042	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
591946014043	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
591946014044	HipA-like N-terminal domain; Region: HipA_N; pfam07805
591946014045	HipA-like C-terminal domain; Region: HipA_C; pfam07804
591946014046	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
591946014047	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
591946014048	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
591946014049	hypothetical protein; Provisional; Region: PRK11246
591946014050	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
591946014051	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591946014052	motif II; other site
591946014053	DNA repair protein RadA; Region: sms; TIGR00416
591946014054	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
591946014055	Walker A motif/ATP binding site; other site
591946014056	ATP binding site [chemical binding]; other site
591946014057	Walker B motif; other site
591946014058	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
591946014059	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946014060	non-specific DNA binding site [nucleotide binding]; other site
591946014061	salt bridge; other site
591946014062	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
591946014063	sequence-specific DNA binding site [nucleotide binding]; other site
591946014064	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
591946014065	active site
591946014066	(T/H)XGH motif; other site
591946014067	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
591946014068	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
591946014069	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591946014070	non-specific DNA binding site [nucleotide binding]; other site
591946014071	salt bridge; other site
591946014072	sequence-specific DNA binding site [nucleotide binding]; other site
591946014073	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
591946014074	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591946014075	Walker A/P-loop; other site
591946014076	ATP binding site [chemical binding]; other site
591946014077	Q-loop/lid; other site
591946014078	ABC transporter signature motif; other site
591946014079	Walker B; other site
591946014080	D-loop; other site
591946014081	H-loop/switch region; other site
591946014082	ABC transporter; Region: ABC_tran_2; pfam12848
591946014083	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591946014084	lytic murein transglycosylase; Provisional; Region: PRK11619
591946014085	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591946014086	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591946014087	catalytic residue [active]
591946014088	Trp operon repressor; Provisional; Region: PRK01381
591946014089	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
591946014090	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591946014091	catalytic core [active]
591946014092	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
591946014093	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591946014094	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
591946014095	hypothetical protein; Provisional; Region: PRK10756
591946014096	CreA protein; Region: CreA; pfam05981
591946014097	DNA-binding response regulator CreB; Provisional; Region: PRK11083
591946014098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946014099	active site
591946014100	phosphorylation site [posttranslational modification]
591946014101	intermolecular recognition site; other site
591946014102	dimerization interface [polypeptide binding]; other site
591946014103	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946014104	DNA binding site [nucleotide binding]
591946014105	sensory histidine kinase CreC; Provisional; Region: PRK11100
591946014106	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591946014107	dimerization interface [polypeptide binding]; other site
591946014108	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591946014109	dimer interface [polypeptide binding]; other site
591946014110	phosphorylation site [posttranslational modification]
591946014111	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591946014112	ATP binding site [chemical binding]; other site
591946014113	Mg2+ binding site [ion binding]; other site
591946014114	G-X-G motif; other site
591946014115	Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452
591946014116	two-component response regulator; Provisional; Region: PRK11173
591946014117	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591946014118	active site
591946014119	phosphorylation site [posttranslational modification]
591946014120	intermolecular recognition site; other site
591946014121	dimerization interface [polypeptide binding]; other site
591946014122	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591946014123	DNA binding site [nucleotide binding]
591946014124	putative RNA methyltransferase; Provisional; Region: PRK10433
591946014125	RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050