-- dump date 20140619_085114 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1033813000001 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1033813000002 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1033813000003 Sulfatase; Region: Sulfatase; pfam00884 1033813000004 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1033813000005 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1033813000006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813000007 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1033813000008 putative dimerization interface [polypeptide binding]; other site 1033813000009 putative alpha-glucosidase; Provisional; Region: PRK10658 1033813000010 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 1033813000011 putative active site [active] 1033813000012 putative catalytic site [active] 1033813000013 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1033813000014 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1033813000015 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1033813000016 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1033813000017 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1033813000018 active site 1033813000019 Riboflavin kinase; Region: Flavokinase; smart00904 1033813000020 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1033813000021 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1033813000022 HIGH motif; other site 1033813000023 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1033813000024 active site 1033813000025 KMSKS motif; other site 1033813000026 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1033813000027 tRNA binding surface [nucleotide binding]; other site 1033813000028 anticodon binding site; other site 1033813000029 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1033813000030 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1033813000031 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1033813000032 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1033813000033 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1033813000034 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1033813000035 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1033813000036 active site 1033813000037 tetramer interface [polypeptide binding]; other site 1033813000038 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1033813000039 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1033813000040 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1033813000041 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1033813000042 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1033813000043 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1033813000044 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1033813000045 catalytic site [active] 1033813000046 subunit interface [polypeptide binding]; other site 1033813000047 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1033813000048 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1033813000049 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1033813000050 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1033813000051 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1033813000052 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1033813000053 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1033813000054 IMP binding site; other site 1033813000055 dimer interface [polypeptide binding]; other site 1033813000056 interdomain contacts; other site 1033813000057 partial ornithine binding site; other site 1033813000058 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 1033813000059 carnitine operon protein CaiE; Provisional; Region: PRK13627 1033813000060 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1033813000061 putative trimer interface [polypeptide binding]; other site 1033813000062 putative metal binding site [ion binding]; other site 1033813000063 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1033813000064 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1033813000065 substrate binding site [chemical binding]; other site 1033813000066 oxyanion hole (OAH) forming residues; other site 1033813000067 trimer interface [polypeptide binding]; other site 1033813000068 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 1033813000069 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1033813000070 acyl-activating enzyme (AAE) consensus motif; other site 1033813000071 putative AMP binding site [chemical binding]; other site 1033813000072 putative active site [active] 1033813000073 putative CoA binding site [chemical binding]; other site 1033813000074 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 1033813000075 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1033813000076 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1033813000077 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1033813000078 active site 1033813000079 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 1033813000080 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1033813000081 Ligand binding site [chemical binding]; other site 1033813000082 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1033813000083 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 1033813000084 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 1033813000085 Ligand binding site [chemical binding]; other site 1033813000086 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1033813000087 putative oxidoreductase FixC; Provisional; Region: PRK10157 1033813000088 ferredoxin-like protein FixX; Provisional; Region: PRK15449 1033813000089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813000090 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1033813000091 putative substrate translocation pore; other site 1033813000092 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1033813000093 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1033813000094 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1033813000095 TrkA-N domain; Region: TrkA_N; pfam02254 1033813000096 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1033813000097 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1033813000098 folate binding site [chemical binding]; other site 1033813000099 NADP+ binding site [chemical binding]; other site 1033813000100 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1033813000101 CcdB protein; Region: CcdB; pfam01845 1033813000102 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1033813000103 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1033813000104 active site 1033813000105 metal binding site [ion binding]; metal-binding site 1033813000106 Protein of unknown function (DUF525); Region: DUF525; cl01119 1033813000107 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1033813000108 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1033813000109 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1033813000110 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1033813000111 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1033813000112 SurA N-terminal domain; Region: SurA_N; pfam09312 1033813000113 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1033813000114 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1033813000115 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1033813000116 OstA-like protein; Region: OstA; pfam03968 1033813000117 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1033813000118 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1033813000119 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1033813000120 putative metal binding site [ion binding]; other site 1033813000121 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1033813000122 HSP70 interaction site [polypeptide binding]; other site 1033813000123 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1033813000124 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1033813000125 active site 1033813000126 ATP-dependent helicase HepA; Validated; Region: PRK04914 1033813000127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033813000128 ATP binding site [chemical binding]; other site 1033813000129 putative Mg++ binding site [ion binding]; other site 1033813000130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813000131 nucleotide binding region [chemical binding]; other site 1033813000132 ATP-binding site [chemical binding]; other site 1033813000133 DNA polymerase II; Reviewed; Region: PRK05762 1033813000134 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1033813000135 active site 1033813000136 catalytic site [active] 1033813000137 substrate binding site [chemical binding]; other site 1033813000138 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1033813000139 active site 1033813000140 metal-binding site 1033813000141 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1033813000142 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1033813000143 intersubunit interface [polypeptide binding]; other site 1033813000144 active site 1033813000145 Zn2+ binding site [ion binding]; other site 1033813000146 L-arabinose isomerase; Provisional; Region: PRK02929 1033813000147 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1033813000148 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1033813000149 trimer interface [polypeptide binding]; other site 1033813000150 putative substrate binding site [chemical binding]; other site 1033813000151 putative metal binding site [ion binding]; other site 1033813000152 ribulokinase; Provisional; Region: PRK04123 1033813000153 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1033813000154 N- and C-terminal domain interface [polypeptide binding]; other site 1033813000155 active site 1033813000156 MgATP binding site [chemical binding]; other site 1033813000157 catalytic site [active] 1033813000158 metal binding site [ion binding]; metal-binding site 1033813000159 carbohydrate binding site [chemical binding]; other site 1033813000160 homodimer interface [polypeptide binding]; other site 1033813000161 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1033813000162 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1033813000163 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813000164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813000165 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1033813000166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1033813000167 putative DNA binding site [nucleotide binding]; other site 1033813000168 putative Zn2+ binding site [ion binding]; other site 1033813000169 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1033813000170 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1033813000171 substrate binding site [chemical binding]; other site 1033813000172 dimer interface [polypeptide binding]; other site 1033813000173 ATP binding site [chemical binding]; other site 1033813000174 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1033813000175 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1033813000176 inhibitor site; inhibition site 1033813000177 active site 1033813000178 dimer interface [polypeptide binding]; other site 1033813000179 catalytic residue [active] 1033813000180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1033813000181 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 1033813000182 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1033813000183 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1033813000184 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1033813000185 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1033813000186 Walker A/P-loop; other site 1033813000187 ATP binding site [chemical binding]; other site 1033813000188 Q-loop/lid; other site 1033813000189 ABC transporter signature motif; other site 1033813000190 Walker B; other site 1033813000191 D-loop; other site 1033813000192 H-loop/switch region; other site 1033813000193 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1033813000194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813000195 dimer interface [polypeptide binding]; other site 1033813000196 conserved gate region; other site 1033813000197 putative PBP binding loops; other site 1033813000198 ABC-ATPase subunit interface; other site 1033813000199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813000200 dimer interface [polypeptide binding]; other site 1033813000201 conserved gate region; other site 1033813000202 putative PBP binding loops; other site 1033813000203 ABC-ATPase subunit interface; other site 1033813000204 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1033813000205 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1033813000206 transcriptional regulator SgrR; Provisional; Region: PRK13626 1033813000207 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1033813000208 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1033813000209 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1033813000210 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1033813000211 substrate binding site [chemical binding]; other site 1033813000212 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1033813000213 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1033813000214 substrate binding site [chemical binding]; other site 1033813000215 ligand binding site [chemical binding]; other site 1033813000216 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1033813000217 tartrate dehydrogenase; Region: TTC; TIGR02089 1033813000218 2-isopropylmalate synthase; Validated; Region: PRK00915 1033813000219 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1033813000220 active site 1033813000221 catalytic residues [active] 1033813000222 metal binding site [ion binding]; metal-binding site 1033813000223 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1033813000224 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1033813000225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813000226 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1033813000227 putative substrate binding pocket [chemical binding]; other site 1033813000228 putative dimerization interface [polypeptide binding]; other site 1033813000229 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1033813000230 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1033813000231 PYR/PP interface [polypeptide binding]; other site 1033813000232 dimer interface [polypeptide binding]; other site 1033813000233 TPP binding site [chemical binding]; other site 1033813000234 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1033813000235 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1033813000236 TPP-binding site [chemical binding]; other site 1033813000237 dimer interface [polypeptide binding]; other site 1033813000238 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1033813000239 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1033813000240 putative valine binding site [chemical binding]; other site 1033813000241 dimer interface [polypeptide binding]; other site 1033813000242 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1033813000243 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1033813000244 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813000245 DNA binding site [nucleotide binding] 1033813000246 domain linker motif; other site 1033813000247 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1033813000248 dimerization interface [polypeptide binding]; other site 1033813000249 ligand binding site [chemical binding]; other site 1033813000250 mraZ protein; Region: TIGR00242 1033813000251 MraZ protein; Region: MraZ; pfam02381 1033813000252 MraZ protein; Region: MraZ; pfam02381 1033813000253 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1033813000254 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1033813000255 cell division protein FtsL; Provisional; Region: PRK10772 1033813000256 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1033813000257 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1033813000258 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1033813000259 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1033813000260 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1033813000261 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1033813000262 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1033813000263 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1033813000264 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1033813000265 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1033813000266 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1033813000267 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1033813000268 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1033813000269 Mg++ binding site [ion binding]; other site 1033813000270 putative catalytic motif [active] 1033813000271 putative substrate binding site [chemical binding]; other site 1033813000272 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1033813000273 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1033813000274 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1033813000275 cell division protein FtsW; Provisional; Region: PRK10774 1033813000276 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1033813000277 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1033813000278 active site 1033813000279 homodimer interface [polypeptide binding]; other site 1033813000280 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1033813000281 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1033813000282 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1033813000283 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1033813000284 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1033813000285 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1033813000286 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1033813000287 cell division protein FtsQ; Provisional; Region: PRK10775 1033813000288 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1033813000289 Cell division protein FtsQ; Region: FtsQ; pfam03799 1033813000290 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1033813000291 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033813000292 Cell division protein FtsA; Region: FtsA; pfam14450 1033813000293 cell division protein FtsZ; Validated; Region: PRK09330 1033813000294 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1033813000295 nucleotide binding site [chemical binding]; other site 1033813000296 SulA interaction site; other site 1033813000297 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1033813000298 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1033813000299 SecA regulator SecM; Provisional; Region: PRK02943 1033813000300 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1033813000301 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1033813000302 SEC-C motif; Region: SEC-C; pfam02810 1033813000303 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1033813000304 active site 1033813000305 8-oxo-dGMP binding site [chemical binding]; other site 1033813000306 nudix motif; other site 1033813000307 metal binding site [ion binding]; metal-binding site 1033813000308 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1033813000309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1033813000310 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1033813000311 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1033813000312 CoA-binding site [chemical binding]; other site 1033813000313 ATP-binding [chemical binding]; other site 1033813000314 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1033813000315 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1033813000316 active site 1033813000317 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1033813000318 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1033813000319 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1033813000320 Type II/IV secretion system protein; Region: T2SE; pfam00437 1033813000321 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1033813000322 Walker A motif; other site 1033813000323 ATP binding site [chemical binding]; other site 1033813000324 Walker B motif; other site 1033813000325 putative major pilin subunit; Provisional; Region: PRK10574 1033813000326 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1033813000327 Pilin (bacterial filament); Region: Pilin; pfam00114 1033813000328 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1033813000329 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1033813000330 dimerization interface [polypeptide binding]; other site 1033813000331 active site 1033813000332 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1033813000333 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1033813000334 amidase catalytic site [active] 1033813000335 Zn binding residues [ion binding]; other site 1033813000336 substrate binding site [chemical binding]; other site 1033813000337 regulatory protein AmpE; Provisional; Region: PRK10987 1033813000338 aromatic amino acid transporter; Provisional; Region: PRK10238 1033813000339 Protein of unknown function (DUF796); Region: DUF796; cl01226 1033813000340 S-type Pyocin; Region: Pyocin_S; pfam06958 1033813000341 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1033813000342 active site 1033813000343 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1033813000344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813000345 DNA-binding site [nucleotide binding]; DNA binding site 1033813000346 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1033813000347 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1033813000348 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1033813000349 dimer interface [polypeptide binding]; other site 1033813000350 TPP-binding site [chemical binding]; other site 1033813000351 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1033813000352 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1033813000353 E3 interaction surface; other site 1033813000354 lipoyl attachment site [posttranslational modification]; other site 1033813000355 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1033813000356 E3 interaction surface; other site 1033813000357 lipoyl attachment site [posttranslational modification]; other site 1033813000358 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1033813000359 E3 interaction surface; other site 1033813000360 lipoyl attachment site [posttranslational modification]; other site 1033813000361 e3 binding domain; Region: E3_binding; pfam02817 1033813000362 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1033813000363 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1033813000364 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1033813000365 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813000366 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1033813000367 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1033813000368 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1033813000369 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1033813000370 substrate binding site [chemical binding]; other site 1033813000371 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1033813000372 substrate binding site [chemical binding]; other site 1033813000373 ligand binding site [chemical binding]; other site 1033813000374 hypothetical protein; Provisional; Region: PRK05248 1033813000375 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1033813000376 spermidine synthase; Provisional; Region: PRK00811 1033813000377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813000378 S-adenosylmethionine binding site [chemical binding]; other site 1033813000379 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1033813000380 multicopper oxidase; Provisional; Region: PRK10965 1033813000381 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1033813000382 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1033813000383 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1033813000384 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1033813000385 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1033813000386 Trp docking motif [polypeptide binding]; other site 1033813000387 putative active site [active] 1033813000388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033813000389 active site 1033813000390 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1033813000391 active site clefts [active] 1033813000392 zinc binding site [ion binding]; other site 1033813000393 dimer interface [polypeptide binding]; other site 1033813000394 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1033813000395 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1033813000396 Walker A/P-loop; other site 1033813000397 ATP binding site [chemical binding]; other site 1033813000398 Q-loop/lid; other site 1033813000399 ABC transporter signature motif; other site 1033813000400 Walker B; other site 1033813000401 D-loop; other site 1033813000402 H-loop/switch region; other site 1033813000403 inner membrane transport permease; Provisional; Region: PRK15066 1033813000404 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1033813000405 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1033813000406 active pocket/dimerization site; other site 1033813000407 active site 1033813000408 phosphorylation site [posttranslational modification] 1033813000409 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1033813000410 putative active site [active] 1033813000411 putative metal binding site [ion binding]; other site 1033813000412 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1033813000413 tetramerization interface [polypeptide binding]; other site 1033813000414 active site 1033813000415 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1033813000416 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1033813000417 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1033813000418 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1033813000419 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1033813000420 active site 1033813000421 ATP-binding site [chemical binding]; other site 1033813000422 pantoate-binding site; other site 1033813000423 HXXH motif; other site 1033813000424 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1033813000425 metal binding site [ion binding]; metal-binding site 1033813000426 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 1033813000427 PapC N-terminal domain; Region: PapC_N; pfam13954 1033813000428 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1033813000429 PapC C-terminal domain; Region: PapC_C; pfam13953 1033813000430 putative chaperone protein EcpD; Provisional; Region: PRK09926 1033813000431 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1033813000432 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1033813000433 Fimbrial protein; Region: Fimbrial; cl01416 1033813000434 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1033813000435 catalytic center binding site [active] 1033813000436 ATP binding site [chemical binding]; other site 1033813000437 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1033813000438 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1033813000439 active site 1033813000440 NTP binding site [chemical binding]; other site 1033813000441 metal binding triad [ion binding]; metal-binding site 1033813000442 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1033813000443 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1033813000444 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1033813000445 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1033813000446 active site 1033813000447 nucleotide binding site [chemical binding]; other site 1033813000448 HIGH motif; other site 1033813000449 KMSKS motif; other site 1033813000450 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1033813000451 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1033813000452 2'-5' RNA ligase; Provisional; Region: PRK15124 1033813000453 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1033813000454 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1033813000455 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1033813000456 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033813000457 ATP binding site [chemical binding]; other site 1033813000458 putative Mg++ binding site [ion binding]; other site 1033813000459 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813000460 nucleotide binding region [chemical binding]; other site 1033813000461 ATP-binding site [chemical binding]; other site 1033813000462 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1033813000463 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1033813000464 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1033813000465 Transglycosylase; Region: Transgly; pfam00912 1033813000466 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1033813000467 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1033813000468 PapC N-terminal domain; Region: PapC_N; pfam13954 1033813000469 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1033813000470 PapC C-terminal domain; Region: PapC_C; pfam13953 1033813000471 Fimbrial protein; Region: Fimbrial; pfam00419 1033813000472 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1033813000473 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813000474 N-terminal plug; other site 1033813000475 ligand-binding site [chemical binding]; other site 1033813000476 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1033813000477 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1033813000478 Walker A/P-loop; other site 1033813000479 ATP binding site [chemical binding]; other site 1033813000480 Q-loop/lid; other site 1033813000481 ABC transporter signature motif; other site 1033813000482 Walker B; other site 1033813000483 D-loop; other site 1033813000484 H-loop/switch region; other site 1033813000485 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1033813000486 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1033813000487 siderophore binding site; other site 1033813000488 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1033813000489 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813000490 ABC-ATPase subunit interface; other site 1033813000491 dimer interface [polypeptide binding]; other site 1033813000492 putative PBP binding regions; other site 1033813000493 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813000494 ABC-ATPase subunit interface; other site 1033813000495 dimer interface [polypeptide binding]; other site 1033813000496 putative PBP binding regions; other site 1033813000497 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1033813000498 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1033813000499 inhibitor-cofactor binding pocket; inhibition site 1033813000500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813000501 catalytic residue [active] 1033813000502 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1033813000503 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1033813000504 Cl- selectivity filter; other site 1033813000505 Cl- binding residues [ion binding]; other site 1033813000506 pore gating glutamate residue; other site 1033813000507 dimer interface [polypeptide binding]; other site 1033813000508 H+/Cl- coupling transport residue; other site 1033813000509 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1033813000510 hypothetical protein; Provisional; Region: PRK10578 1033813000511 UPF0126 domain; Region: UPF0126; pfam03458 1033813000512 UPF0126 domain; Region: UPF0126; pfam03458 1033813000513 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1033813000514 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1033813000515 cobalamin binding residues [chemical binding]; other site 1033813000516 putative BtuC binding residues; other site 1033813000517 dimer interface [polypeptide binding]; other site 1033813000518 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1033813000519 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1033813000520 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1033813000521 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1033813000522 Zn2+ binding site [ion binding]; other site 1033813000523 Mg2+ binding site [ion binding]; other site 1033813000524 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1033813000525 serine endoprotease; Provisional; Region: PRK10942 1033813000526 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1033813000527 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1033813000528 protein binding site [polypeptide binding]; other site 1033813000529 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1033813000530 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1033813000531 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1033813000532 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1033813000533 hypothetical protein; Provisional; Region: PRK13677 1033813000534 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1033813000535 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1033813000536 trimer interface [polypeptide binding]; other site 1033813000537 active site 1033813000538 substrate binding site [chemical binding]; other site 1033813000539 CoA binding site [chemical binding]; other site 1033813000540 PII uridylyl-transferase; Provisional; Region: PRK05007 1033813000541 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1033813000542 metal binding triad; other site 1033813000543 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1033813000544 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1033813000545 Zn2+ binding site [ion binding]; other site 1033813000546 Mg2+ binding site [ion binding]; other site 1033813000547 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1033813000548 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1033813000549 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1033813000550 active site 1033813000551 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1033813000552 rRNA interaction site [nucleotide binding]; other site 1033813000553 S8 interaction site; other site 1033813000554 putative laminin-1 binding site; other site 1033813000555 elongation factor Ts; Provisional; Region: tsf; PRK09377 1033813000556 UBA/TS-N domain; Region: UBA; pfam00627 1033813000557 Elongation factor TS; Region: EF_TS; pfam00889 1033813000558 Elongation factor TS; Region: EF_TS; pfam00889 1033813000559 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1033813000560 putative nucleotide binding site [chemical binding]; other site 1033813000561 uridine monophosphate binding site [chemical binding]; other site 1033813000562 homohexameric interface [polypeptide binding]; other site 1033813000563 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1033813000564 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1033813000565 hinge region; other site 1033813000566 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1033813000567 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1033813000568 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1033813000569 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1033813000570 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1033813000571 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1033813000572 catalytic residue [active] 1033813000573 putative FPP diphosphate binding site; other site 1033813000574 putative FPP binding hydrophobic cleft; other site 1033813000575 dimer interface [polypeptide binding]; other site 1033813000576 putative IPP diphosphate binding site; other site 1033813000577 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1033813000578 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1033813000579 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1033813000580 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1033813000581 active site 1033813000582 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1033813000583 protein binding site [polypeptide binding]; other site 1033813000584 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1033813000585 putative substrate binding region [chemical binding]; other site 1033813000586 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1033813000587 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1033813000588 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1033813000589 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1033813000590 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1033813000591 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1033813000592 Surface antigen; Region: Bac_surface_Ag; pfam01103 1033813000593 periplasmic chaperone; Provisional; Region: PRK10780 1033813000594 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1033813000595 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1033813000596 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1033813000597 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1033813000598 trimer interface [polypeptide binding]; other site 1033813000599 active site 1033813000600 UDP-GlcNAc binding site [chemical binding]; other site 1033813000601 lipid binding site [chemical binding]; lipid-binding site 1033813000602 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1033813000603 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1033813000604 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1033813000605 active site 1033813000606 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1033813000607 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1033813000608 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1033813000609 RNA/DNA hybrid binding site [nucleotide binding]; other site 1033813000610 active site 1033813000611 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1033813000612 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1033813000613 putative active site [active] 1033813000614 putative PHP Thumb interface [polypeptide binding]; other site 1033813000615 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1033813000616 generic binding surface II; other site 1033813000617 generic binding surface I; other site 1033813000618 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1033813000619 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1033813000620 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1033813000621 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1033813000622 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1033813000623 homodimer interface [polypeptide binding]; other site 1033813000624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813000625 catalytic residue [active] 1033813000626 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1033813000627 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1033813000628 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1033813000629 putative metal binding site [ion binding]; other site 1033813000630 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1033813000631 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1033813000632 Ligand Binding Site [chemical binding]; other site 1033813000633 TilS substrate binding domain; Region: TilS; pfam09179 1033813000634 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1033813000635 Rho-binding antiterminator; Provisional; Region: PRK11625 1033813000636 hypothetical protein; Provisional; Region: PRK04964 1033813000637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1033813000638 hypothetical protein; Provisional; Region: PRK09256 1033813000639 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1033813000640 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1033813000641 NlpE N-terminal domain; Region: NlpE; pfam04170 1033813000642 hypothetical protein; Provisional; Region: PRK11479 1033813000643 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1033813000644 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1033813000645 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1033813000646 dimer interface [polypeptide binding]; other site 1033813000647 motif 1; other site 1033813000648 active site 1033813000649 motif 2; other site 1033813000650 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1033813000651 putative deacylase active site [active] 1033813000652 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1033813000653 active site 1033813000654 motif 3; other site 1033813000655 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1033813000656 anticodon binding site; other site 1033813000657 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1033813000658 homodimer interaction site [polypeptide binding]; other site 1033813000659 cofactor binding site; other site 1033813000660 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1033813000661 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1033813000662 lipoprotein, YaeC family; Region: TIGR00363 1033813000663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813000664 dimer interface [polypeptide binding]; other site 1033813000665 conserved gate region; other site 1033813000666 ABC-ATPase subunit interface; other site 1033813000667 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1033813000668 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1033813000669 Walker A/P-loop; other site 1033813000670 ATP binding site [chemical binding]; other site 1033813000671 Q-loop/lid; other site 1033813000672 ABC transporter signature motif; other site 1033813000673 Walker B; other site 1033813000674 D-loop; other site 1033813000675 H-loop/switch region; other site 1033813000676 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1033813000677 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 1033813000678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813000679 active site 1033813000680 motif I; other site 1033813000681 motif II; other site 1033813000682 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033813000683 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033813000684 active site 1033813000685 catalytic tetrad [active] 1033813000686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033813000687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813000688 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1033813000689 putative effector binding pocket; other site 1033813000690 dimerization interface [polypeptide binding]; other site 1033813000691 hypothetical protein; Provisional; Region: PRK05421 1033813000692 putative catalytic site [active] 1033813000693 putative metal binding site [ion binding]; other site 1033813000694 putative phosphate binding site [ion binding]; other site 1033813000695 putative catalytic site [active] 1033813000696 putative phosphate binding site [ion binding]; other site 1033813000697 putative metal binding site [ion binding]; other site 1033813000698 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1033813000699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813000700 S-adenosylmethionine binding site [chemical binding]; other site 1033813000701 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1033813000702 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1033813000703 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1033813000704 catalytic residue [active] 1033813000705 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1033813000706 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1033813000707 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1033813000708 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1033813000709 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1033813000710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813000711 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1033813000712 RNA/DNA hybrid binding site [nucleotide binding]; other site 1033813000713 active site 1033813000714 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1033813000715 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1033813000716 active site 1033813000717 catalytic site [active] 1033813000718 substrate binding site [chemical binding]; other site 1033813000719 C-N hydrolase family amidase; Provisional; Region: PRK10438 1033813000720 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1033813000721 putative active site [active] 1033813000722 catalytic triad [active] 1033813000723 dimer interface [polypeptide binding]; other site 1033813000724 multimer interface [polypeptide binding]; other site 1033813000725 C-lysozyme inhibitor; Provisional; Region: PRK09993 1033813000726 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1033813000727 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1033813000728 active site 1033813000729 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1033813000730 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1033813000731 dimer interface [polypeptide binding]; other site 1033813000732 active site 1033813000733 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1033813000734 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1033813000735 putative active site [active] 1033813000736 putative dimer interface [polypeptide binding]; other site 1033813000737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1033813000738 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1033813000739 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1033813000740 NlpC/P60 family; Region: NLPC_P60; pfam00877 1033813000741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1033813000742 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 1033813000743 FHIPEP family; Region: FHIPEP; pfam00771 1033813000744 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1033813000745 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1033813000746 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 1033813000747 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1033813000748 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1033813000749 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1033813000750 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1033813000751 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1033813000752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813000753 Walker A motif; other site 1033813000754 ATP binding site [chemical binding]; other site 1033813000755 Walker B motif; other site 1033813000756 arginine finger; other site 1033813000757 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1033813000758 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1033813000759 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 1033813000760 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1033813000761 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1033813000762 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 1033813000763 MgtE intracellular N domain; Region: MgtE_N; smart00924 1033813000764 FliG C-terminal domain; Region: FliG_C; pfam01706 1033813000765 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 1033813000766 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1033813000767 Flagellar assembly protein FliH; Region: FliH; pfam02108 1033813000768 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 1033813000769 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1033813000770 Walker A motif/ATP binding site; other site 1033813000771 Walker B motif; other site 1033813000772 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1033813000773 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1033813000774 active site 1033813000775 nucleotide binding site [chemical binding]; other site 1033813000776 HIGH motif; other site 1033813000777 KMSKS motif; other site 1033813000778 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1033813000779 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1033813000780 active site 1033813000781 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 1033813000782 FlgN protein; Region: FlgN; pfam05130 1033813000783 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1033813000784 SAF-like; Region: SAF_2; pfam13144 1033813000785 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1033813000786 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1033813000787 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1033813000788 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 1033813000789 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 1033813000790 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1033813000791 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619 1033813000792 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1033813000793 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1033813000794 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 1033813000795 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1033813000796 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1033813000797 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1033813000798 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1033813000799 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1033813000800 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1033813000801 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1033813000802 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1033813000803 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 1033813000804 Flagellar L-ring protein; Region: FlgH; pfam02107 1033813000805 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1033813000806 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1033813000807 Rod binding protein; Region: Rod-binding; cl01626 1033813000808 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 1033813000809 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1033813000810 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 1033813000811 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1033813000812 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1033813000813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1033813000814 DNA binding site [nucleotide binding] 1033813000815 flagellin; Reviewed; Region: PRK08869 1033813000816 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1033813000817 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1033813000818 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1033813000819 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1033813000820 Flagellar protein FliS; Region: FliS; cl00654 1033813000821 adenylate kinase; Region: PLN02674 1033813000822 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1033813000823 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1033813000824 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 1033813000825 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1033813000826 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1033813000827 DNA binding residues [nucleotide binding] 1033813000828 flagellar motor protein MotA; Provisional; Region: PRK12482 1033813000829 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1033813000830 hypothetical protein; Validated; Region: PRK06778 1033813000831 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1033813000832 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1033813000833 ligand binding site [chemical binding]; other site 1033813000834 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1033813000835 active site 1033813000836 DNA polymerase IV; Validated; Region: PRK02406 1033813000837 DNA binding site [nucleotide binding] 1033813000838 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1033813000839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813000840 Coenzyme A binding pocket [chemical binding]; other site 1033813000841 hypothetical protein; Reviewed; Region: PRK09588 1033813000842 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 1033813000843 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1033813000844 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1033813000845 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1033813000846 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1033813000847 metal binding site [ion binding]; metal-binding site 1033813000848 dimer interface [polypeptide binding]; other site 1033813000849 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033813000850 active site 1033813000851 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1033813000852 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1033813000853 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1033813000854 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1033813000855 trimer interface [polypeptide binding]; other site 1033813000856 eyelet of channel; other site 1033813000857 gamma-glutamyl kinase; Provisional; Region: PRK05429 1033813000858 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1033813000859 nucleotide binding site [chemical binding]; other site 1033813000860 homotetrameric interface [polypeptide binding]; other site 1033813000861 putative phosphate binding site [ion binding]; other site 1033813000862 putative allosteric binding site; other site 1033813000863 PUA domain; Region: PUA; pfam01472 1033813000864 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1033813000865 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1033813000866 putative catalytic cysteine [active] 1033813000867 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1033813000868 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1033813000869 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1033813000870 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1033813000871 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1033813000872 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1033813000873 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033813000874 ATP binding site [chemical binding]; other site 1033813000875 putative Mg++ binding site [ion binding]; other site 1033813000876 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1033813000877 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 1033813000878 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1033813000879 potential frameshift: common BLAST hit: gi|339998310|ref|YP_004729193.1| prophage integrase 1033813000880 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033813000881 active site 1033813000882 DNA binding site [nucleotide binding] 1033813000883 Int/Topo IB signature motif; other site 1033813000884 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1033813000885 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1033813000886 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1033813000887 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1033813000888 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1033813000889 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813000890 DNA binding residues [nucleotide binding] 1033813000891 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1033813000892 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033813000893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813000894 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1033813000895 putative effector binding pocket; other site 1033813000896 putative dimerization interface [polypeptide binding]; other site 1033813000897 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033813000898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813000899 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1033813000900 putative effector binding pocket; other site 1033813000901 putative dimerization interface [polypeptide binding]; other site 1033813000902 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033813000903 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033813000904 active site 1033813000905 catalytic tetrad [active] 1033813000906 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033813000907 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033813000908 active site 1033813000909 catalytic tetrad [active] 1033813000910 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1033813000911 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1033813000912 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1033813000913 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1033813000914 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1033813000915 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1033813000916 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813000917 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1033813000918 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033813000919 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033813000920 active site 1033813000921 catalytic tetrad [active] 1033813000922 Predicted membrane protein [Function unknown]; Region: COG3059 1033813000923 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1033813000924 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 1033813000925 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1033813000926 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813000927 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1033813000928 Cupin; Region: Cupin_6; pfam12852 1033813000929 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1033813000930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813000931 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1033813000932 Cysteine-rich domain; Region: CCG; pfam02754 1033813000933 Cysteine-rich domain; Region: CCG; pfam02754 1033813000934 iron-sulfur cluster-binding protein; Region: TIGR00273 1033813000935 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1033813000936 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1033813000937 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1033813000938 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1033813000939 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1033813000940 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 1033813000941 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1033813000942 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1033813000943 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1033813000944 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813000945 DNA binding residues [nucleotide binding] 1033813000946 dimerization interface [polypeptide binding]; other site 1033813000947 choline dehydrogenase; Validated; Region: PRK02106 1033813000948 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1033813000949 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1033813000950 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1033813000951 tetrameric interface [polypeptide binding]; other site 1033813000952 NAD binding site [chemical binding]; other site 1033813000953 catalytic residues [active] 1033813000954 transcriptional regulator BetI; Validated; Region: PRK00767 1033813000955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813000956 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1033813000957 choline transport protein BetT; Provisional; Region: PRK09928 1033813000958 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813000959 DNA binding residues [nucleotide binding] 1033813000960 dimerization interface [polypeptide binding]; other site 1033813000961 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813000962 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1033813000963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813000964 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1033813000965 dimerization interface [polypeptide binding]; other site 1033813000966 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1033813000967 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1033813000968 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1033813000969 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1033813000970 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1033813000971 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 1033813000972 CoA binding domain; Region: CoA_binding; pfam02629 1033813000973 CoA-ligase; Region: Ligase_CoA; pfam00549 1033813000974 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1033813000975 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1033813000976 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1033813000977 putative substrate binding site [chemical binding]; other site 1033813000978 nucleotide binding site [chemical binding]; other site 1033813000979 nucleotide binding site [chemical binding]; other site 1033813000980 homodimer interface [polypeptide binding]; other site 1033813000981 putative deaminase; Validated; Region: PRK06846 1033813000982 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1033813000983 active site 1033813000984 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1033813000985 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1033813000986 putative NAD(P) binding site [chemical binding]; other site 1033813000987 putative substrate binding site [chemical binding]; other site 1033813000988 catalytic Zn binding site [ion binding]; other site 1033813000989 structural Zn binding site [ion binding]; other site 1033813000990 dimer interface [polypeptide binding]; other site 1033813000991 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1033813000992 hypothetical protein; Provisional; Region: PRK09929 1033813000993 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 1033813000994 Propionate catabolism activator; Region: PrpR_N; pfam06506 1033813000995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813000996 Walker A motif; other site 1033813000997 ATP binding site [chemical binding]; other site 1033813000998 Walker B motif; other site 1033813000999 arginine finger; other site 1033813001000 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1033813001001 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1033813001002 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1033813001003 tetramer interface [polypeptide binding]; other site 1033813001004 active site 1033813001005 Mg2+/Mn2+ binding site [ion binding]; other site 1033813001006 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1033813001007 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1033813001008 dimer interface [polypeptide binding]; other site 1033813001009 active site 1033813001010 citrylCoA binding site [chemical binding]; other site 1033813001011 oxalacetate/citrate binding site [chemical binding]; other site 1033813001012 coenzyme A binding site [chemical binding]; other site 1033813001013 catalytic triad [active] 1033813001014 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1033813001015 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1033813001016 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1033813001017 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1033813001018 acyl-activating enzyme (AAE) consensus motif; other site 1033813001019 putative AMP binding site [chemical binding]; other site 1033813001020 putative active site [active] 1033813001021 putative CoA binding site [chemical binding]; other site 1033813001022 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1033813001023 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1033813001024 Na binding site [ion binding]; other site 1033813001025 putative substrate binding site [chemical binding]; other site 1033813001026 cytosine deaminase; Provisional; Region: PRK09230 1033813001027 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1033813001028 active site 1033813001029 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1033813001030 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1033813001031 active site 1033813001032 substrate binding site [chemical binding]; other site 1033813001033 trimer interface [polypeptide binding]; other site 1033813001034 CoA binding site [chemical binding]; other site 1033813001035 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 1033813001036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813001037 putative substrate translocation pore; other site 1033813001038 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1033813001039 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1033813001040 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1033813001041 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1033813001042 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1033813001043 lac repressor; Reviewed; Region: lacI; PRK09526 1033813001044 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813001045 DNA binding site [nucleotide binding] 1033813001046 domain linker motif; other site 1033813001047 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1033813001048 ligand binding site [chemical binding]; other site 1033813001049 dimerization interface (open form) [polypeptide binding]; other site 1033813001050 dimerization interface (closed form) [polypeptide binding]; other site 1033813001051 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1033813001052 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1033813001053 Bacterial transcriptional regulator; Region: IclR; pfam01614 1033813001054 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1033813001055 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1033813001056 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 1033813001057 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1033813001058 putative active site [active] 1033813001059 Fe(II) binding site [ion binding]; other site 1033813001060 putative dimer interface [polypeptide binding]; other site 1033813001061 putative tetramer interface [polypeptide binding]; other site 1033813001062 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1033813001063 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 1033813001064 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1033813001065 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1033813001066 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1033813001067 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1033813001068 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1033813001069 active site 1033813001070 catalytic residues [active] 1033813001071 metal binding site [ion binding]; metal-binding site 1033813001072 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1033813001073 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1033813001074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813001075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1033813001076 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1033813001077 S-formylglutathione hydrolase; Region: PLN02442 1033813001078 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1033813001079 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1033813001080 substrate binding site [chemical binding]; other site 1033813001081 catalytic Zn binding site [ion binding]; other site 1033813001082 NAD binding site [chemical binding]; other site 1033813001083 structural Zn binding site [ion binding]; other site 1033813001084 dimer interface [polypeptide binding]; other site 1033813001085 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1033813001086 putative homodimer-homodimer interface [polypeptide binding]; other site 1033813001087 putative allosteric switch controlling residues; other site 1033813001088 putative metal binding site [ion binding]; other site 1033813001089 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1033813001090 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813001091 substrate binding pocket [chemical binding]; other site 1033813001092 membrane-bound complex binding site; other site 1033813001093 hinge residues; other site 1033813001094 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1033813001095 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1033813001096 Walker A/P-loop; other site 1033813001097 ATP binding site [chemical binding]; other site 1033813001098 Q-loop/lid; other site 1033813001099 ABC transporter signature motif; other site 1033813001100 Walker B; other site 1033813001101 D-loop; other site 1033813001102 H-loop/switch region; other site 1033813001103 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1033813001104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813001105 dimer interface [polypeptide binding]; other site 1033813001106 conserved gate region; other site 1033813001107 putative PBP binding loops; other site 1033813001108 ABC-ATPase subunit interface; other site 1033813001109 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1033813001110 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1033813001111 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1033813001112 dimer interface [polypeptide binding]; other site 1033813001113 active site 1033813001114 Schiff base residues; other site 1033813001115 potential frameshift: common BLAST hit: gi|218557283|ref|YP_002390196.1| flagellin-like structural protein 1033813001116 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1033813001117 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1033813001118 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1033813001119 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1033813001120 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1033813001121 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1033813001122 microcin B17 transporter; Reviewed; Region: PRK11098 1033813001123 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1033813001124 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1033813001125 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1033813001126 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1033813001127 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1033813001128 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1033813001129 anti-RssB factor; Provisional; Region: PRK10244 1033813001130 alkaline phosphatase; Provisional; Region: PRK10518 1033813001131 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1033813001132 dimer interface [polypeptide binding]; other site 1033813001133 active site 1033813001134 hypothetical protein; Provisional; Region: PRK11505 1033813001135 psiF repeat; Region: PsiF_repeat; pfam07769 1033813001136 psiF repeat; Region: PsiF_repeat; pfam07769 1033813001137 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1033813001138 MASE2 domain; Region: MASE2; pfam05230 1033813001139 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813001140 metal binding site [ion binding]; metal-binding site 1033813001141 active site 1033813001142 I-site; other site 1033813001143 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1033813001144 pyrroline-5-carboxylate reductase; Region: PLN02688 1033813001145 hypothetical protein; Validated; Region: PRK00124 1033813001146 Shikimate kinase; Region: SKI; pfam01202 1033813001147 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1033813001148 magnesium binding site [ion binding]; other site 1033813001149 putative shikimate binding site; other site 1033813001150 hypothetical protein; Provisional; Region: PRK10380 1033813001151 hypothetical protein; Provisional; Region: PRK10481 1033813001152 hypothetical protein; Provisional; Region: PRK10579 1033813001153 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1033813001154 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 1033813001155 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1033813001156 fructokinase; Reviewed; Region: PRK09557 1033813001157 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033813001158 nucleotide binding site [chemical binding]; other site 1033813001159 MFS transport protein AraJ; Provisional; Region: PRK10091 1033813001160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813001161 putative substrate translocation pore; other site 1033813001162 exonuclease subunit SbcC; Provisional; Region: PRK10246 1033813001163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813001164 Walker A/P-loop; other site 1033813001165 ATP binding site [chemical binding]; other site 1033813001166 Q-loop/lid; other site 1033813001167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813001168 ABC transporter signature motif; other site 1033813001169 Walker B; other site 1033813001170 D-loop; other site 1033813001171 H-loop/switch region; other site 1033813001172 exonuclease subunit SbcD; Provisional; Region: PRK10966 1033813001173 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1033813001174 active site 1033813001175 metal binding site [ion binding]; metal-binding site 1033813001176 DNA binding site [nucleotide binding] 1033813001177 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1033813001178 transcriptional regulator PhoB; Provisional; Region: PRK10161 1033813001179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813001180 active site 1033813001181 phosphorylation site [posttranslational modification] 1033813001182 intermolecular recognition site; other site 1033813001183 dimerization interface [polypeptide binding]; other site 1033813001184 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813001185 DNA binding site [nucleotide binding] 1033813001186 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1033813001187 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1033813001188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813001189 putative active site [active] 1033813001190 heme pocket [chemical binding]; other site 1033813001191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813001192 dimer interface [polypeptide binding]; other site 1033813001193 phosphorylation site [posttranslational modification] 1033813001194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813001195 ATP binding site [chemical binding]; other site 1033813001196 Mg2+ binding site [ion binding]; other site 1033813001197 G-X-G motif; other site 1033813001198 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1033813001199 putative proline-specific permease; Provisional; Region: proY; PRK10580 1033813001200 Spore germination protein; Region: Spore_permease; cl17796 1033813001201 maltodextrin glucosidase; Provisional; Region: PRK10785 1033813001202 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1033813001203 homodimer interface [polypeptide binding]; other site 1033813001204 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1033813001205 active site 1033813001206 homodimer interface [polypeptide binding]; other site 1033813001207 catalytic site [active] 1033813001208 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1033813001209 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1033813001210 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1033813001211 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1033813001212 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1033813001213 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1033813001214 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1033813001215 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1033813001216 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1033813001217 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1033813001218 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1033813001219 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1033813001220 Protein export membrane protein; Region: SecD_SecF; pfam02355 1033813001221 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1033813001222 active site 1033813001223 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1033813001224 hypothetical protein; Provisional; Region: PRK11530 1033813001225 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1033813001226 ATP cone domain; Region: ATP-cone; pfam03477 1033813001227 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1033813001228 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1033813001229 catalytic motif [active] 1033813001230 Zn binding site [ion binding]; other site 1033813001231 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1033813001232 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1033813001233 homopentamer interface [polypeptide binding]; other site 1033813001234 active site 1033813001235 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1033813001236 putative RNA binding site [nucleotide binding]; other site 1033813001237 thiamine monophosphate kinase; Provisional; Region: PRK05731 1033813001238 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1033813001239 ATP binding site [chemical binding]; other site 1033813001240 dimerization interface [polypeptide binding]; other site 1033813001241 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1033813001242 tetramer interfaces [polypeptide binding]; other site 1033813001243 binuclear metal-binding site [ion binding]; other site 1033813001244 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033813001245 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033813001246 active site 1033813001247 catalytic tetrad [active] 1033813001248 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1033813001249 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1033813001250 TPP-binding site; other site 1033813001251 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1033813001252 PYR/PP interface [polypeptide binding]; other site 1033813001253 dimer interface [polypeptide binding]; other site 1033813001254 TPP binding site [chemical binding]; other site 1033813001255 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1033813001256 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1033813001257 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1033813001258 substrate binding pocket [chemical binding]; other site 1033813001259 chain length determination region; other site 1033813001260 substrate-Mg2+ binding site; other site 1033813001261 catalytic residues [active] 1033813001262 aspartate-rich region 1; other site 1033813001263 active site lid residues [active] 1033813001264 aspartate-rich region 2; other site 1033813001265 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1033813001266 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1033813001267 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1033813001268 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1033813001269 Ligand Binding Site [chemical binding]; other site 1033813001270 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1033813001271 active site residue [active] 1033813001272 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1033813001273 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1033813001274 conserved cys residue [active] 1033813001275 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1033813001276 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1033813001277 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1033813001278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1033813001279 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1033813001280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813001281 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1033813001282 putative substrate translocation pore; other site 1033813001283 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1033813001284 UbiA prenyltransferase family; Region: UbiA; pfam01040 1033813001285 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1033813001286 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1033813001287 Subunit I/III interface [polypeptide binding]; other site 1033813001288 Subunit III/IV interface [polypeptide binding]; other site 1033813001289 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1033813001290 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1033813001291 D-pathway; other site 1033813001292 Putative ubiquinol binding site [chemical binding]; other site 1033813001293 Low-spin heme (heme b) binding site [chemical binding]; other site 1033813001294 Putative water exit pathway; other site 1033813001295 Binuclear center (heme o3/CuB) [ion binding]; other site 1033813001296 K-pathway; other site 1033813001297 Putative proton exit pathway; other site 1033813001298 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1033813001299 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1033813001300 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1033813001301 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1033813001302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813001303 putative substrate translocation pore; other site 1033813001304 hypothetical protein; Provisional; Region: PRK11627 1033813001305 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1033813001306 transcriptional regulator BolA; Provisional; Region: PRK11628 1033813001307 trigger factor; Provisional; Region: tig; PRK01490 1033813001308 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1033813001309 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1033813001310 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1033813001311 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1033813001312 oligomer interface [polypeptide binding]; other site 1033813001313 active site residues [active] 1033813001314 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1033813001315 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1033813001316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813001317 Walker A motif; other site 1033813001318 ATP binding site [chemical binding]; other site 1033813001319 Walker B motif; other site 1033813001320 Iron permease FTR1 family; Region: FTR1; cl00475 1033813001321 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1033813001322 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1033813001323 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1033813001324 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1033813001325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813001326 Walker A motif; other site 1033813001327 ATP binding site [chemical binding]; other site 1033813001328 Walker B motif; other site 1033813001329 arginine finger; other site 1033813001330 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1033813001331 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1033813001332 IHF dimer interface [polypeptide binding]; other site 1033813001333 IHF - DNA interface [nucleotide binding]; other site 1033813001334 periplasmic folding chaperone; Provisional; Region: PRK10788 1033813001335 SurA N-terminal domain; Region: SurA_N_3; cl07813 1033813001336 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1033813001337 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1033813001338 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1033813001339 active site 1033813001340 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1033813001341 Ligand Binding Site [chemical binding]; other site 1033813001342 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1033813001343 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1033813001344 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1033813001345 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1033813001346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813001347 active site 1033813001348 motif I; other site 1033813001349 motif II; other site 1033813001350 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1033813001351 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1033813001352 putative DNA binding site [nucleotide binding]; other site 1033813001353 putative Zn2+ binding site [ion binding]; other site 1033813001354 AsnC family; Region: AsnC_trans_reg; pfam01037 1033813001355 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033813001356 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1033813001357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813001358 Walker A/P-loop; other site 1033813001359 ATP binding site [chemical binding]; other site 1033813001360 Q-loop/lid; other site 1033813001361 ABC transporter signature motif; other site 1033813001362 Walker B; other site 1033813001363 D-loop; other site 1033813001364 H-loop/switch region; other site 1033813001365 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1033813001366 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033813001367 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1033813001368 Walker A/P-loop; other site 1033813001369 ATP binding site [chemical binding]; other site 1033813001370 Q-loop/lid; other site 1033813001371 ABC transporter signature motif; other site 1033813001372 Walker B; other site 1033813001373 D-loop; other site 1033813001374 H-loop/switch region; other site 1033813001375 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1033813001376 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1033813001377 ammonium transporter; Provisional; Region: PRK10666 1033813001378 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1033813001379 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1033813001380 active site 1033813001381 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1033813001382 catalytic triad [active] 1033813001383 dimer interface [polypeptide binding]; other site 1033813001384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1033813001385 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1033813001386 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1033813001387 DNA binding site [nucleotide binding] 1033813001388 active site 1033813001389 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 1033813001390 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1033813001391 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1033813001392 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813001393 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1033813001394 maltose O-acetyltransferase; Provisional; Region: PRK10092 1033813001395 Maltose acetyltransferase; Region: Mac; pfam12464 1033813001396 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1033813001397 trimer interface [polypeptide binding]; other site 1033813001398 active site 1033813001399 substrate binding site [chemical binding]; other site 1033813001400 CoA binding site [chemical binding]; other site 1033813001401 gene expression modulator; Provisional; Region: PRK10945 1033813001402 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 1033813001403 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1033813001404 Protein export membrane protein; Region: SecD_SecF; cl14618 1033813001405 Protein export membrane protein; Region: SecD_SecF; cl14618 1033813001406 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1033813001407 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813001408 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813001409 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1033813001410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813001411 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1033813001412 hypothetical protein; Provisional; Region: PRK11281 1033813001413 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1033813001414 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1033813001415 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1033813001416 hypothetical protein; Provisional; Region: PRK11038 1033813001417 primosomal replication protein N''; Provisional; Region: PRK10093 1033813001418 hypothetical protein; Provisional; Region: PRK10527 1033813001419 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033813001420 active site 1033813001421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813001422 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1033813001423 Walker A motif; other site 1033813001424 ATP binding site [chemical binding]; other site 1033813001425 Walker B motif; other site 1033813001426 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1033813001427 arginine finger; other site 1033813001428 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1033813001429 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1033813001430 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1033813001431 hypothetical protein; Validated; Region: PRK00153 1033813001432 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 1033813001433 RecR protein; Region: RecR; pfam02132 1033813001434 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1033813001435 putative active site [active] 1033813001436 putative metal-binding site [ion binding]; other site 1033813001437 tetramer interface [polypeptide binding]; other site 1033813001438 heat shock protein 90; Provisional; Region: PRK05218 1033813001439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813001440 ATP binding site [chemical binding]; other site 1033813001441 Mg2+ binding site [ion binding]; other site 1033813001442 G-X-G motif; other site 1033813001443 adenylate kinase; Reviewed; Region: adk; PRK00279 1033813001444 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1033813001445 AMP-binding site [chemical binding]; other site 1033813001446 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1033813001447 ferrochelatase; Region: hemH; TIGR00109 1033813001448 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1033813001449 C-terminal domain interface [polypeptide binding]; other site 1033813001450 active site 1033813001451 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1033813001452 active site 1033813001453 N-terminal domain interface [polypeptide binding]; other site 1033813001454 acetyl esterase; Provisional; Region: PRK10162 1033813001455 inosine/guanosine kinase; Provisional; Region: PRK15074 1033813001456 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1033813001457 putative cation:proton antiport protein; Provisional; Region: PRK10669 1033813001458 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1033813001459 TrkA-N domain; Region: TrkA_N; pfam02254 1033813001460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813001461 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1033813001462 putative substrate translocation pore; other site 1033813001463 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1033813001464 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1033813001465 active site 1033813001466 metal binding site [ion binding]; metal-binding site 1033813001467 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1033813001468 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1033813001469 putative deacylase active site [active] 1033813001470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1033813001471 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1033813001472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813001473 non-specific DNA binding site [nucleotide binding]; other site 1033813001474 salt bridge; other site 1033813001475 sequence-specific DNA binding site [nucleotide binding]; other site 1033813001476 copper exporting ATPase; Provisional; Region: copA; PRK10671 1033813001477 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1033813001478 metal-binding site [ion binding] 1033813001479 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1033813001480 metal-binding site [ion binding] 1033813001481 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033813001482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813001483 motif II; other site 1033813001484 glutaminase; Reviewed; Region: PRK12356 1033813001485 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1033813001486 amino acid transporter; Region: 2A0306; TIGR00909 1033813001487 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1033813001488 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1033813001489 DNA binding residues [nucleotide binding] 1033813001490 dimer interface [polypeptide binding]; other site 1033813001491 copper binding site [ion binding]; other site 1033813001492 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1033813001493 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1033813001494 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1033813001495 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1033813001496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813001497 Walker A/P-loop; other site 1033813001498 ATP binding site [chemical binding]; other site 1033813001499 Q-loop/lid; other site 1033813001500 ABC transporter signature motif; other site 1033813001501 Walker B; other site 1033813001502 D-loop; other site 1033813001503 H-loop/switch region; other site 1033813001504 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 1033813001505 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1033813001506 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1033813001507 oxidoreductase; Provisional; Region: PRK08017 1033813001508 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1033813001509 NADP binding site [chemical binding]; other site 1033813001510 active site 1033813001511 steroid binding site; other site 1033813001512 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1033813001513 active site 1033813001514 catalytic triad [active] 1033813001515 oxyanion hole [active] 1033813001516 switch loop; other site 1033813001517 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1033813001518 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1033813001519 Walker A/P-loop; other site 1033813001520 ATP binding site [chemical binding]; other site 1033813001521 Q-loop/lid; other site 1033813001522 ABC transporter signature motif; other site 1033813001523 Walker B; other site 1033813001524 D-loop; other site 1033813001525 H-loop/switch region; other site 1033813001526 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1033813001527 FtsX-like permease family; Region: FtsX; pfam02687 1033813001528 FtsX-like permease family; Region: FtsX; pfam02687 1033813001529 Protein of unknown function (DUF796); Region: DUF796; cl01226 1033813001530 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1033813001531 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 1033813001532 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1033813001533 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1033813001534 active site residue [active] 1033813001535 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1033813001536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813001537 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1033813001538 dimerization interface [polypeptide binding]; other site 1033813001539 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1033813001540 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1033813001541 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 1033813001542 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1033813001543 Bacterial transcriptional regulator; Region: IclR; pfam01614 1033813001544 glyoxylate carboligase; Provisional; Region: PRK11269 1033813001545 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1033813001546 PYR/PP interface [polypeptide binding]; other site 1033813001547 dimer interface [polypeptide binding]; other site 1033813001548 TPP binding site [chemical binding]; other site 1033813001549 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1033813001550 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1033813001551 TPP-binding site [chemical binding]; other site 1033813001552 hydroxypyruvate isomerase; Provisional; Region: PRK09997 1033813001553 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1033813001554 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1033813001555 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 1033813001556 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1033813001557 Na binding site [ion binding]; other site 1033813001558 substrate binding site [chemical binding]; other site 1033813001559 allantoinase; Provisional; Region: PRK08044 1033813001560 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1033813001561 active site 1033813001562 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1033813001563 glycerate kinase II; Provisional; Region: PRK09932 1033813001564 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 1033813001565 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 1033813001566 Cupin domain; Region: Cupin_2; cl17218 1033813001567 allantoate amidohydrolase; Region: AllC; TIGR03176 1033813001568 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1033813001569 active site 1033813001570 metal binding site [ion binding]; metal-binding site 1033813001571 dimer interface [polypeptide binding]; other site 1033813001572 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 1033813001573 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1033813001574 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1033813001575 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1033813001576 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1033813001577 putative substrate binding site [chemical binding]; other site 1033813001578 nucleotide binding site [chemical binding]; other site 1033813001579 nucleotide binding site [chemical binding]; other site 1033813001580 homodimer interface [polypeptide binding]; other site 1033813001581 hypothetical protein; Provisional; Region: PRK09936 1033813001582 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 1033813001583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1033813001584 TPR motif; other site 1033813001585 binding surface 1033813001586 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 1033813001587 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 1033813001588 active site 1033813001589 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1033813001590 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1033813001591 sensor kinase CusS; Provisional; Region: PRK09835 1033813001592 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033813001593 dimerization interface [polypeptide binding]; other site 1033813001594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813001595 dimer interface [polypeptide binding]; other site 1033813001596 phosphorylation site [posttranslational modification] 1033813001597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813001598 ATP binding site [chemical binding]; other site 1033813001599 Mg2+ binding site [ion binding]; other site 1033813001600 G-X-G motif; other site 1033813001601 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 1033813001602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813001603 active site 1033813001604 phosphorylation site [posttranslational modification] 1033813001605 intermolecular recognition site; other site 1033813001606 dimerization interface [polypeptide binding]; other site 1033813001607 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813001608 DNA binding site [nucleotide binding] 1033813001609 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1033813001610 periplasmic copper-binding protein; Provisional; Region: PRK09838 1033813001611 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1033813001612 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813001613 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1033813001614 phenylalanine transporter; Provisional; Region: PRK10249 1033813001615 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1033813001616 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1033813001617 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1033813001618 dimer interface [polypeptide binding]; other site 1033813001619 FMN binding site [chemical binding]; other site 1033813001620 hypothetical protein; Provisional; Region: PRK10250 1033813001621 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1033813001622 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1033813001623 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1033813001624 Hok/gef family; Region: HOK_GEF; pfam01848 1033813001625 short chain dehydrogenase; Provisional; Region: PRK06114 1033813001626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1033813001627 NAD(P) binding site [chemical binding]; other site 1033813001628 active site 1033813001629 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1033813001630 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1033813001631 NAD binding site [chemical binding]; other site 1033813001632 homotetramer interface [polypeptide binding]; other site 1033813001633 homodimer interface [polypeptide binding]; other site 1033813001634 active site 1033813001635 substrate binding site [chemical binding]; other site 1033813001636 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1033813001637 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033813001638 TM-ABC transporter signature motif; other site 1033813001639 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1033813001640 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1033813001641 Walker A/P-loop; other site 1033813001642 ATP binding site [chemical binding]; other site 1033813001643 Q-loop/lid; other site 1033813001644 ABC transporter signature motif; other site 1033813001645 Walker B; other site 1033813001646 D-loop; other site 1033813001647 H-loop/switch region; other site 1033813001648 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1033813001649 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 1033813001650 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1033813001651 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1033813001652 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 1033813001653 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1033813001654 N- and C-terminal domain interface [polypeptide binding]; other site 1033813001655 active site 1033813001656 MgATP binding site [chemical binding]; other site 1033813001657 catalytic site [active] 1033813001658 metal binding site [ion binding]; metal-binding site 1033813001659 putative homotetramer interface [polypeptide binding]; other site 1033813001660 putative homodimer interface [polypeptide binding]; other site 1033813001661 glycerol binding site [chemical binding]; other site 1033813001662 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1033813001663 MarR family; Region: MarR_2; cl17246 1033813001664 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1033813001665 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1033813001666 TPP-binding site [chemical binding]; other site 1033813001667 dimer interface [polypeptide binding]; other site 1033813001668 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1033813001669 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1033813001670 PYR/PP interface [polypeptide binding]; other site 1033813001671 dimer interface [polypeptide binding]; other site 1033813001672 TPP binding site [chemical binding]; other site 1033813001673 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1033813001674 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1033813001675 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1033813001676 outer membrane receptor FepA; Provisional; Region: PRK13524 1033813001677 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813001678 N-terminal plug; other site 1033813001679 ligand-binding site [chemical binding]; other site 1033813001680 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1033813001681 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1033813001682 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1033813001683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1033813001684 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1033813001685 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1033813001686 acyl-activating enzyme (AAE) consensus motif; other site 1033813001687 AMP binding site [chemical binding]; other site 1033813001688 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1033813001689 LPS O-antigen length regulator; Provisional; Region: PRK10381 1033813001690 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1033813001691 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1033813001692 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1033813001693 Walker A/P-loop; other site 1033813001694 ATP binding site [chemical binding]; other site 1033813001695 Q-loop/lid; other site 1033813001696 ABC transporter signature motif; other site 1033813001697 Walker B; other site 1033813001698 D-loop; other site 1033813001699 H-loop/switch region; other site 1033813001700 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1033813001701 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813001702 ABC-ATPase subunit interface; other site 1033813001703 dimer interface [polypeptide binding]; other site 1033813001704 putative PBP binding regions; other site 1033813001705 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1033813001706 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813001707 ABC-ATPase subunit interface; other site 1033813001708 dimer interface [polypeptide binding]; other site 1033813001709 putative PBP binding regions; other site 1033813001710 enterobactin exporter EntS; Provisional; Region: PRK10489 1033813001711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813001712 putative substrate translocation pore; other site 1033813001713 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1033813001714 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1033813001715 siderophore binding site; other site 1033813001716 isochorismate synthase EntC; Provisional; Region: PRK15016 1033813001717 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1033813001718 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1033813001719 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1033813001720 acyl-activating enzyme (AAE) consensus motif; other site 1033813001721 active site 1033813001722 AMP binding site [chemical binding]; other site 1033813001723 substrate binding site [chemical binding]; other site 1033813001724 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1033813001725 hydrophobic substrate binding pocket; other site 1033813001726 Isochorismatase family; Region: Isochorismatase; pfam00857 1033813001727 active site 1033813001728 conserved cis-peptide bond; other site 1033813001729 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1033813001730 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1033813001731 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1033813001732 putative NAD(P) binding site [chemical binding]; other site 1033813001733 active site 1033813001734 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1033813001735 CoenzymeA binding site [chemical binding]; other site 1033813001736 subunit interaction site [polypeptide binding]; other site 1033813001737 PHB binding site; other site 1033813001738 carbon starvation protein A; Provisional; Region: PRK15015 1033813001739 Carbon starvation protein CstA; Region: CstA; pfam02554 1033813001740 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1033813001741 Uncharacterized small protein [Function unknown]; Region: COG2879 1033813001742 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1033813001743 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1033813001744 putative active site [active] 1033813001745 metal binding site [ion binding]; metal-binding site 1033813001746 methionine aminotransferase; Validated; Region: PRK09082 1033813001747 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1033813001748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813001749 homodimer interface [polypeptide binding]; other site 1033813001750 catalytic residue [active] 1033813001751 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1033813001752 ParB-like nuclease domain; Region: ParBc; pfam02195 1033813001753 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1033813001754 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1033813001755 Active Sites [active] 1033813001756 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1033813001757 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1033813001758 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1033813001759 dimerization domain [polypeptide binding]; other site 1033813001760 dimer interface [polypeptide binding]; other site 1033813001761 catalytic residues [active] 1033813001762 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1033813001763 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1033813001764 dimer interface [polypeptide binding]; other site 1033813001765 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1033813001766 catalytic triad [active] 1033813001767 peroxidatic and resolving cysteines [active] 1033813001768 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1033813001769 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1033813001770 catalytic residue [active] 1033813001771 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1033813001772 catalytic residues [active] 1033813001773 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1033813001774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813001775 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1033813001776 Ligand Binding Site [chemical binding]; other site 1033813001777 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1033813001778 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1033813001779 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1033813001780 B1 nucleotide binding pocket [chemical binding]; other site 1033813001781 B2 nucleotide binding pocket [chemical binding]; other site 1033813001782 CAS motifs; other site 1033813001783 active site 1033813001784 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1033813001785 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1033813001786 transmembrane helices; other site 1033813001787 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 1033813001788 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1033813001789 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1033813001790 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1033813001791 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1033813001792 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1033813001793 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1033813001794 putative active site [active] 1033813001795 (T/H)XGH motif; other site 1033813001796 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1033813001797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813001798 putative active site [active] 1033813001799 heme pocket [chemical binding]; other site 1033813001800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813001801 ATP binding site [chemical binding]; other site 1033813001802 Mg2+ binding site [ion binding]; other site 1033813001803 G-X-G motif; other site 1033813001804 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1033813001805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813001806 active site 1033813001807 phosphorylation site [posttranslational modification] 1033813001808 intermolecular recognition site; other site 1033813001809 dimerization interface [polypeptide binding]; other site 1033813001810 Transcriptional regulator; Region: CitT; pfam12431 1033813001811 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1033813001812 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1033813001813 chromosome condensation membrane protein; Provisional; Region: PRK14196 1033813001814 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1033813001815 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1033813001816 putative active site [active] 1033813001817 catalytic triad [active] 1033813001818 putative dimer interface [polypeptide binding]; other site 1033813001819 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1033813001820 lipoyl synthase; Provisional; Region: PRK05481 1033813001821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813001822 FeS/SAM binding site; other site 1033813001823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813001824 lipoate-protein ligase B; Provisional; Region: PRK14342 1033813001825 hypothetical protein; Provisional; Region: PRK04998 1033813001826 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1033813001827 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1033813001828 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1033813001829 rare lipoprotein A; Provisional; Region: PRK10672 1033813001830 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1033813001831 Sporulation related domain; Region: SPOR; pfam05036 1033813001832 cell wall shape-determining protein; Provisional; Region: PRK10794 1033813001833 penicillin-binding protein 2; Provisional; Region: PRK10795 1033813001834 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1033813001835 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1033813001836 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1033813001837 ribosome-associated protein; Provisional; Region: PRK11538 1033813001838 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033813001839 catalytic core [active] 1033813001840 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1033813001841 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1033813001842 active site 1033813001843 (T/H)XGH motif; other site 1033813001844 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1033813001845 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1033813001846 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1033813001847 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1033813001848 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1033813001849 HIGH motif; other site 1033813001850 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1033813001851 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1033813001852 active site 1033813001853 KMSKS motif; other site 1033813001854 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1033813001855 tRNA binding surface [nucleotide binding]; other site 1033813001856 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1033813001857 hypothetical protein; Provisional; Region: PRK11032 1033813001858 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1033813001859 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1033813001860 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1033813001861 Sel1-like repeats; Region: SEL1; smart00671 1033813001862 Sel1-like repeats; Region: SEL1; smart00671 1033813001863 Sel1-like repeats; Region: SEL1; smart00671 1033813001864 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1033813001865 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1033813001866 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1033813001867 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 1033813001868 nucleotide binding site [chemical binding]; other site 1033813001869 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1033813001870 SBD interface [polypeptide binding]; other site 1033813001871 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1033813001872 active site 1033813001873 tetramer interface [polypeptide binding]; other site 1033813001874 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1033813001875 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1033813001876 Walker A/P-loop; other site 1033813001877 ATP binding site [chemical binding]; other site 1033813001878 Q-loop/lid; other site 1033813001879 ABC transporter signature motif; other site 1033813001880 Walker B; other site 1033813001881 D-loop; other site 1033813001882 H-loop/switch region; other site 1033813001883 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1033813001884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813001885 dimer interface [polypeptide binding]; other site 1033813001886 conserved gate region; other site 1033813001887 putative PBP binding loops; other site 1033813001888 ABC-ATPase subunit interface; other site 1033813001889 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1033813001890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813001891 dimer interface [polypeptide binding]; other site 1033813001892 conserved gate region; other site 1033813001893 putative PBP binding loops; other site 1033813001894 ABC-ATPase subunit interface; other site 1033813001895 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1033813001896 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813001897 substrate binding pocket [chemical binding]; other site 1033813001898 membrane-bound complex binding site; other site 1033813001899 hinge residues; other site 1033813001900 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1033813001901 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1033813001902 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1033813001903 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1033813001904 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1033813001905 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1033813001906 putative active site [active] 1033813001907 catalytic triad [active] 1033813001908 putative dimer interface [polypeptide binding]; other site 1033813001909 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1033813001910 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1033813001911 Transporter associated domain; Region: CorC_HlyC; smart01091 1033813001912 metal-binding heat shock protein; Provisional; Region: PRK00016 1033813001913 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1033813001914 PhoH-like protein; Region: PhoH; pfam02562 1033813001915 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1033813001916 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1033813001917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813001918 FeS/SAM binding site; other site 1033813001919 TRAM domain; Region: TRAM; pfam01938 1033813001920 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1033813001921 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1033813001922 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1033813001923 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1033813001924 active site 1033813001925 dimer interface [polypeptide binding]; other site 1033813001926 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1033813001927 Ligand Binding Site [chemical binding]; other site 1033813001928 Molecular Tunnel; other site 1033813001929 UMP phosphatase; Provisional; Region: PRK10444 1033813001930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813001931 active site 1033813001932 motif I; other site 1033813001933 motif II; other site 1033813001934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813001935 MarR family; Region: MarR; pfam01047 1033813001936 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1033813001937 ROK family; Region: ROK; pfam00480 1033813001938 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1033813001939 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1033813001940 active site 1033813001941 dimer interface [polypeptide binding]; other site 1033813001942 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1033813001943 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1033813001944 active site 1033813001945 trimer interface [polypeptide binding]; other site 1033813001946 allosteric site; other site 1033813001947 active site lid [active] 1033813001948 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1033813001949 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1033813001950 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1033813001951 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1033813001952 active site turn [active] 1033813001953 phosphorylation site [posttranslational modification] 1033813001954 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1033813001955 HPr interaction site; other site 1033813001956 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1033813001957 active site 1033813001958 phosphorylation site [posttranslational modification] 1033813001959 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1033813001960 transmembrane helices; other site 1033813001961 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1033813001962 Domain of unknown function (DUF386); Region: DUF386; cl01047 1033813001963 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1033813001964 BNR repeat-like domain; Region: BNR_2; pfam13088 1033813001965 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1033813001966 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1033813001967 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1033813001968 inhibitor site; inhibition site 1033813001969 active site 1033813001970 dimer interface [polypeptide binding]; other site 1033813001971 catalytic residue [active] 1033813001972 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1033813001973 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1033813001974 putative active site [active] 1033813001975 metal binding site [ion binding]; metal-binding site 1033813001976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1033813001977 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1033813001978 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1033813001979 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1033813001980 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1033813001981 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813001982 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1033813001983 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1033813001984 active site 1033813001985 HIGH motif; other site 1033813001986 nucleotide binding site [chemical binding]; other site 1033813001987 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1033813001988 KMSKS motif; other site 1033813001989 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1033813001990 outer membrane porin, OprD family; Region: OprD; pfam03573 1033813001991 YbfN-like lipoprotein; Region: YbfN; pfam13982 1033813001992 ferric uptake regulator; Provisional; Region: fur; PRK09462 1033813001993 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1033813001994 metal binding site 2 [ion binding]; metal-binding site 1033813001995 putative DNA binding helix; other site 1033813001996 metal binding site 1 [ion binding]; metal-binding site 1033813001997 dimer interface [polypeptide binding]; other site 1033813001998 structural Zn2+ binding site [ion binding]; other site 1033813001999 flavodoxin FldA; Validated; Region: PRK09267 1033813002000 LexA regulated protein; Provisional; Region: PRK11675 1033813002001 acyl-CoA esterase; Provisional; Region: PRK10673 1033813002002 PGAP1-like protein; Region: PGAP1; pfam07819 1033813002003 replication initiation regulator SeqA; Provisional; Region: PRK11187 1033813002004 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1033813002005 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1033813002006 active site 1033813002007 substrate binding site [chemical binding]; other site 1033813002008 metal binding site [ion binding]; metal-binding site 1033813002009 putrescine transporter; Provisional; Region: potE; PRK10655 1033813002010 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1033813002011 ornithine decarboxylase; Provisional; Region: PRK13578 1033813002012 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1033813002013 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1033813002014 homodimer interface [polypeptide binding]; other site 1033813002015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813002016 catalytic residue [active] 1033813002017 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1033813002018 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1033813002019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813002020 active site 1033813002021 phosphorylation site [posttranslational modification] 1033813002022 intermolecular recognition site; other site 1033813002023 dimerization interface [polypeptide binding]; other site 1033813002024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813002025 DNA binding site [nucleotide binding] 1033813002026 sensor protein KdpD; Provisional; Region: PRK10490 1033813002027 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1033813002028 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1033813002029 Ligand Binding Site [chemical binding]; other site 1033813002030 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1033813002031 GAF domain; Region: GAF_3; pfam13492 1033813002032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813002033 dimer interface [polypeptide binding]; other site 1033813002034 phosphorylation site [posttranslational modification] 1033813002035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813002036 ATP binding site [chemical binding]; other site 1033813002037 Mg2+ binding site [ion binding]; other site 1033813002038 G-X-G motif; other site 1033813002039 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1033813002040 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1033813002041 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033813002042 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1033813002043 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1033813002044 hypothetical protein; Provisional; Region: PRK10167 1033813002045 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1033813002046 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1033813002047 DNA photolyase; Region: DNA_photolyase; pfam00875 1033813002048 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1033813002049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813002050 putative substrate translocation pore; other site 1033813002051 POT family; Region: PTR2; pfam00854 1033813002052 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1033813002053 metal-binding protein; Provisional; Region: PRK10799 1033813002054 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1033813002055 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 1033813002056 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 1033813002057 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1033813002058 putative active site [active] 1033813002059 endonuclease VIII; Provisional; Region: PRK10445 1033813002060 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1033813002061 DNA binding site [nucleotide binding] 1033813002062 catalytic residue [active] 1033813002063 putative catalytic residues [active] 1033813002064 H2TH interface [polypeptide binding]; other site 1033813002065 intercalation triad [nucleotide binding]; other site 1033813002066 substrate specificity determining residue; other site 1033813002067 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1033813002068 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1033813002069 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1033813002070 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1033813002071 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1033813002072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813002073 DNA-binding site [nucleotide binding]; DNA binding site 1033813002074 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1033813002075 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1033813002076 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1033813002077 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1033813002078 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1033813002079 putative NAD(P) binding site [chemical binding]; other site 1033813002080 catalytic Zn binding site [ion binding]; other site 1033813002081 structural Zn binding site [ion binding]; other site 1033813002082 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1033813002083 classical (c) SDRs; Region: SDR_c; cd05233 1033813002084 NAD(P) binding site [chemical binding]; other site 1033813002085 active site 1033813002086 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1033813002087 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1033813002088 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1033813002089 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1033813002090 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1033813002091 DctM-like transporters; Region: DctM; pfam06808 1033813002092 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1033813002093 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1033813002094 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1033813002095 dimer interface [polypeptide binding]; other site 1033813002096 active site 1033813002097 citrylCoA binding site [chemical binding]; other site 1033813002098 NADH binding [chemical binding]; other site 1033813002099 cationic pore residues; other site 1033813002100 oxalacetate/citrate binding site [chemical binding]; other site 1033813002101 coenzyme A binding site [chemical binding]; other site 1033813002102 catalytic triad [active] 1033813002103 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1033813002104 proximal heme binding site [chemical binding]; other site 1033813002105 SdhD (CybS) interface [polypeptide binding]; other site 1033813002106 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1033813002107 SdhC subunit interface [polypeptide binding]; other site 1033813002108 proximal heme binding site [chemical binding]; other site 1033813002109 cardiolipin binding site; other site 1033813002110 Iron-sulfur protein interface; other site 1033813002111 proximal quinone binding site [chemical binding]; other site 1033813002112 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1033813002113 L-aspartate oxidase; Provisional; Region: PRK06175 1033813002114 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1033813002115 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1033813002116 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1033813002117 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1033813002118 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1033813002119 TPP-binding site [chemical binding]; other site 1033813002120 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1033813002121 dimer interface [polypeptide binding]; other site 1033813002122 PYR/PP interface [polypeptide binding]; other site 1033813002123 TPP binding site [chemical binding]; other site 1033813002124 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1033813002125 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1033813002126 E3 interaction surface; other site 1033813002127 lipoyl attachment site [posttranslational modification]; other site 1033813002128 e3 binding domain; Region: E3_binding; pfam02817 1033813002129 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1033813002130 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1033813002131 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1033813002132 CoA-ligase; Region: Ligase_CoA; pfam00549 1033813002133 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1033813002134 CoA binding domain; Region: CoA_binding; smart00881 1033813002135 CoA-ligase; Region: Ligase_CoA; pfam00549 1033813002136 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 1033813002137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813002138 DNA-binding site [nucleotide binding]; DNA binding site 1033813002139 UTRA domain; Region: UTRA; pfam07702 1033813002140 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1033813002141 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033813002142 active site 1033813002143 phosphorylation site [posttranslational modification] 1033813002144 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1033813002145 active site 1033813002146 P-loop; other site 1033813002147 phosphorylation site [posttranslational modification] 1033813002148 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1033813002149 alpha-mannosidase; Provisional; Region: PRK09819 1033813002150 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1033813002151 active site 1033813002152 metal binding site [ion binding]; metal-binding site 1033813002153 catalytic site [active] 1033813002154 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1033813002155 TPR repeat; Region: TPR_11; pfam13414 1033813002156 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1033813002157 binding surface 1033813002158 TPR motif; other site 1033813002159 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1033813002160 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1033813002161 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1033813002162 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1033813002163 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1033813002164 hypothetical protein; Provisional; Region: PRK10588 1033813002165 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1033813002166 active site 1033813002167 colicin uptake protein TolQ; Provisional; Region: PRK10801 1033813002168 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1033813002169 colicin uptake protein TolR; Provisional; Region: PRK11024 1033813002170 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1033813002171 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1033813002172 TolA C-terminal; Region: TolA; pfam06519 1033813002173 translocation protein TolB; Provisional; Region: tolB; PRK03629 1033813002174 TolB amino-terminal domain; Region: TolB_N; pfam04052 1033813002175 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1033813002176 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1033813002177 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1033813002178 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1033813002179 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1033813002180 ligand binding site [chemical binding]; other site 1033813002181 tol-pal system protein YbgF; Provisional; Region: PRK10803 1033813002182 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1033813002183 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1033813002184 quinolinate synthetase; Provisional; Region: PRK09375 1033813002185 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1033813002186 zinc transporter ZitB; Provisional; Region: PRK03557 1033813002187 YbgS-like protein; Region: YbgS; pfam13985 1033813002188 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1033813002189 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1033813002190 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033813002191 catalytic core [active] 1033813002192 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033813002193 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1033813002194 active site 1033813002195 catalytic residues [active] 1033813002196 galactokinase; Provisional; Region: PRK05101 1033813002197 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1033813002198 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1033813002199 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1033813002200 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1033813002201 dimer interface [polypeptide binding]; other site 1033813002202 active site 1033813002203 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1033813002204 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1033813002205 NAD binding site [chemical binding]; other site 1033813002206 homodimer interface [polypeptide binding]; other site 1033813002207 active site 1033813002208 substrate binding site [chemical binding]; other site 1033813002209 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1033813002210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1033813002211 Walker A/P-loop; other site 1033813002212 ATP binding site [chemical binding]; other site 1033813002213 Q-loop/lid; other site 1033813002214 ABC transporter signature motif; other site 1033813002215 Walker B; other site 1033813002216 D-loop; other site 1033813002217 H-loop/switch region; other site 1033813002218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813002219 Walker A/P-loop; other site 1033813002220 ATP binding site [chemical binding]; other site 1033813002221 Q-loop/lid; other site 1033813002222 ABC transporter signature motif; other site 1033813002223 Walker B; other site 1033813002224 D-loop; other site 1033813002225 H-loop/switch region; other site 1033813002226 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1033813002227 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1033813002228 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1033813002229 TOBE domain; Region: TOBE; pfam03459 1033813002230 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1033813002231 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1033813002232 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813002233 substrate binding pocket [chemical binding]; other site 1033813002234 membrane-bound complex binding site; other site 1033813002235 hinge residues; other site 1033813002236 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1033813002237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813002238 dimer interface [polypeptide binding]; other site 1033813002239 conserved gate region; other site 1033813002240 putative PBP binding loops; other site 1033813002241 ABC-ATPase subunit interface; other site 1033813002242 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1033813002243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813002244 Walker A/P-loop; other site 1033813002245 ATP binding site [chemical binding]; other site 1033813002246 Q-loop/lid; other site 1033813002247 ABC transporter signature motif; other site 1033813002248 Walker B; other site 1033813002249 D-loop; other site 1033813002250 H-loop/switch region; other site 1033813002251 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1033813002252 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1033813002253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813002254 motif II; other site 1033813002255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813002256 6-phosphogluconolactonase; Provisional; Region: PRK11028 1033813002257 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033813002258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813002259 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1033813002260 putative dimerization interface [polypeptide binding]; other site 1033813002261 PrpF protein; Region: PrpF; pfam04303 1033813002262 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1033813002263 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1033813002264 transmembrane helices; other site 1033813002265 putative hydratase; Provisional; Region: PRK11413 1033813002266 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1033813002267 substrate binding site [chemical binding]; other site 1033813002268 ligand binding site [chemical binding]; other site 1033813002269 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1033813002270 substrate binding site [chemical binding]; other site 1033813002271 acyl-CoA thioesterase; Provisional; Region: PRK10531 1033813002272 putative pectinesterase; Region: PLN02432; cl01911 1033813002273 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1033813002274 substrate binding site [chemical binding]; other site 1033813002275 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1033813002276 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1033813002277 inhibitor-cofactor binding pocket; inhibition site 1033813002278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813002279 catalytic residue [active] 1033813002280 biotin synthase; Provisional; Region: PRK15108 1033813002281 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813002282 FeS/SAM binding site; other site 1033813002283 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1033813002284 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1033813002285 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1033813002286 substrate-cofactor binding pocket; other site 1033813002287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813002288 catalytic residue [active] 1033813002289 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1033813002290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813002291 S-adenosylmethionine binding site [chemical binding]; other site 1033813002292 AAA domain; Region: AAA_26; pfam13500 1033813002293 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1033813002294 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1033813002295 ADP binding site [chemical binding]; other site 1033813002296 excinuclease ABC subunit B; Provisional; Region: PRK05298 1033813002297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033813002298 ATP binding site [chemical binding]; other site 1033813002299 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813002300 nucleotide binding region [chemical binding]; other site 1033813002301 ATP-binding site [chemical binding]; other site 1033813002302 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1033813002303 UvrB/uvrC motif; Region: UVR; pfam02151 1033813002304 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1033813002305 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1033813002306 putative substrate binding pocket [chemical binding]; other site 1033813002307 dimer interface [polypeptide binding]; other site 1033813002308 phosphate binding site [ion binding]; other site 1033813002309 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1033813002310 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813002311 FeS/SAM binding site; other site 1033813002312 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1033813002313 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1033813002314 MPT binding site; other site 1033813002315 trimer interface [polypeptide binding]; other site 1033813002316 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1033813002317 trimer interface [polypeptide binding]; other site 1033813002318 dimer interface [polypeptide binding]; other site 1033813002319 putative active site [active] 1033813002320 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1033813002321 MoaE interaction surface [polypeptide binding]; other site 1033813002322 MoeB interaction surface [polypeptide binding]; other site 1033813002323 thiocarboxylated glycine; other site 1033813002324 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1033813002325 MoaE homodimer interface [polypeptide binding]; other site 1033813002326 MoaD interaction [polypeptide binding]; other site 1033813002327 active site residues [active] 1033813002328 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1033813002329 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1033813002330 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1033813002331 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1033813002332 Predicted integral membrane protein [Function unknown]; Region: COG0392 1033813002333 cardiolipin synthase 2; Provisional; Region: PRK11263 1033813002334 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1033813002335 putative active site [active] 1033813002336 catalytic site [active] 1033813002337 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1033813002338 putative active site [active] 1033813002339 catalytic site [active] 1033813002340 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1033813002341 putative catalytic site [active] 1033813002342 putative metal binding site [ion binding]; other site 1033813002343 putative phosphate binding site [ion binding]; other site 1033813002344 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1033813002345 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1033813002346 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1033813002347 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1033813002348 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1033813002349 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1033813002350 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1033813002351 Walker A/P-loop; other site 1033813002352 ATP binding site [chemical binding]; other site 1033813002353 Q-loop/lid; other site 1033813002354 ABC transporter signature motif; other site 1033813002355 Walker B; other site 1033813002356 D-loop; other site 1033813002357 H-loop/switch region; other site 1033813002358 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1033813002359 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1033813002360 Walker A/P-loop; other site 1033813002361 ATP binding site [chemical binding]; other site 1033813002362 Q-loop/lid; other site 1033813002363 ABC transporter signature motif; other site 1033813002364 Walker B; other site 1033813002365 D-loop; other site 1033813002366 H-loop/switch region; other site 1033813002367 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1033813002368 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813002369 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813002370 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1033813002371 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1033813002372 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1033813002373 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1033813002374 ATP binding site [chemical binding]; other site 1033813002375 Mg++ binding site [ion binding]; other site 1033813002376 motif III; other site 1033813002377 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813002378 nucleotide binding region [chemical binding]; other site 1033813002379 ATP-binding site [chemical binding]; other site 1033813002380 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 1033813002381 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1033813002382 DEAD_2; Region: DEAD_2; pfam06733 1033813002383 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1033813002384 glycosyl transferase family protein; Provisional; Region: PRK08136 1033813002385 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1033813002386 putative dehydrogenase; Provisional; Region: PRK10098 1033813002387 hypothetical protein; Provisional; Region: PRK10259 1033813002388 hypothetical protein; Provisional; Region: PRK11019 1033813002389 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1033813002390 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 1033813002391 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813002392 N-terminal plug; other site 1033813002393 ligand-binding site [chemical binding]; other site 1033813002394 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1033813002395 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1033813002396 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1033813002397 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1033813002398 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1033813002399 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1033813002400 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1033813002401 Walker A/P-loop; other site 1033813002402 ATP binding site [chemical binding]; other site 1033813002403 Q-loop/lid; other site 1033813002404 ABC transporter signature motif; other site 1033813002405 Walker B; other site 1033813002406 D-loop; other site 1033813002407 H-loop/switch region; other site 1033813002408 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1033813002409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813002410 dimer interface [polypeptide binding]; other site 1033813002411 conserved gate region; other site 1033813002412 putative PBP binding loops; other site 1033813002413 ABC-ATPase subunit interface; other site 1033813002414 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1033813002415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813002416 Walker A motif; other site 1033813002417 ATP binding site [chemical binding]; other site 1033813002418 Walker B motif; other site 1033813002419 Integrase core domain; Region: rve; pfam00665 1033813002420 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1033813002421 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 1033813002422 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1033813002423 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 1033813002424 Protein of unknown function (DUF987); Region: DUF987; pfam06174 1033813002425 Protein of unknown function (DUF987); Region: DUF987; pfam06174 1033813002426 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1033813002427 MPN+ (JAMM) motif; other site 1033813002428 Zinc-binding site [ion binding]; other site 1033813002429 threonine and homoserine efflux system; Provisional; Region: PRK10532 1033813002430 EamA-like transporter family; Region: EamA; pfam00892 1033813002431 outer membrane protein X; Provisional; Region: ompX; PRK09408 1033813002432 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1033813002433 Sulfatase; Region: Sulfatase; pfam00884 1033813002434 manganese transport regulator MntR; Provisional; Region: PRK11050 1033813002435 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1033813002436 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1033813002437 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1033813002438 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1033813002439 transmembrane helices; other site 1033813002440 L,D-transpeptidase; Provisional; Region: PRK10260 1033813002441 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1033813002442 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1033813002443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813002444 Walker A/P-loop; other site 1033813002445 ATP binding site [chemical binding]; other site 1033813002446 Q-loop/lid; other site 1033813002447 ABC transporter signature motif; other site 1033813002448 Walker B; other site 1033813002449 D-loop; other site 1033813002450 H-loop/switch region; other site 1033813002451 ABC transporter; Region: ABC_tran_2; pfam12848 1033813002452 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033813002453 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1033813002454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813002455 active site 1033813002456 motif I; other site 1033813002457 motif II; other site 1033813002458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813002459 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1033813002460 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1033813002461 dimer interface [polypeptide binding]; other site 1033813002462 active site 1033813002463 glycine loop; other site 1033813002464 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1033813002465 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1033813002466 active site 1033813002467 intersubunit interactions; other site 1033813002468 catalytic residue [active] 1033813002469 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1033813002470 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1033813002471 ATP binding site [chemical binding]; other site 1033813002472 substrate interface [chemical binding]; other site 1033813002473 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1033813002474 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1033813002475 dimer interface [polypeptide binding]; other site 1033813002476 putative functional site; other site 1033813002477 putative MPT binding site; other site 1033813002478 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1033813002479 catalytic nucleophile [active] 1033813002480 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1033813002481 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813002482 Walker A/P-loop; other site 1033813002483 ATP binding site [chemical binding]; other site 1033813002484 Q-loop/lid; other site 1033813002485 ABC transporter signature motif; other site 1033813002486 Walker B; other site 1033813002487 D-loop; other site 1033813002488 H-loop/switch region; other site 1033813002489 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1033813002490 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813002491 Walker A/P-loop; other site 1033813002492 ATP binding site [chemical binding]; other site 1033813002493 Q-loop/lid; other site 1033813002494 ABC transporter signature motif; other site 1033813002495 Walker B; other site 1033813002496 D-loop; other site 1033813002497 H-loop/switch region; other site 1033813002498 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1033813002499 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1033813002500 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1033813002501 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1033813002502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813002503 dimer interface [polypeptide binding]; other site 1033813002504 conserved gate region; other site 1033813002505 putative PBP binding loops; other site 1033813002506 ABC-ATPase subunit interface; other site 1033813002507 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1033813002508 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1033813002509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813002510 dimer interface [polypeptide binding]; other site 1033813002511 conserved gate region; other site 1033813002512 putative PBP binding loops; other site 1033813002513 ABC-ATPase subunit interface; other site 1033813002514 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813002515 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1033813002516 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813002517 metal binding site [ion binding]; metal-binding site 1033813002518 active site 1033813002519 I-site; other site 1033813002520 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1033813002521 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1033813002522 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813002523 FeS/SAM binding site; other site 1033813002524 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1033813002525 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1033813002526 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1033813002527 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1033813002528 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1033813002529 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1033813002530 N-terminal domain interface [polypeptide binding]; other site 1033813002531 dimer interface [polypeptide binding]; other site 1033813002532 substrate binding pocket (H-site) [chemical binding]; other site 1033813002533 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1033813002534 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1033813002535 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1033813002536 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1033813002537 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1033813002538 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813002539 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1033813002540 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1033813002541 active site 1033813002542 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1033813002543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813002544 putative substrate translocation pore; other site 1033813002545 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1033813002546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813002547 active site 1033813002548 motif I; other site 1033813002549 motif II; other site 1033813002550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813002551 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1033813002552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813002553 putative substrate translocation pore; other site 1033813002554 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1033813002555 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1033813002556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813002557 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1033813002558 putative transporter; Provisional; Region: PRK04972 1033813002559 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1033813002560 TrkA-C domain; Region: TrkA_C; pfam02080 1033813002561 TrkA-C domain; Region: TrkA_C; pfam02080 1033813002562 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1033813002563 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1033813002564 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1033813002565 GSH binding site [chemical binding]; other site 1033813002566 catalytic residues [active] 1033813002567 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1033813002568 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1033813002569 dimer interface [polypeptide binding]; other site 1033813002570 FMN binding site [chemical binding]; other site 1033813002571 NADPH bind site [chemical binding]; other site 1033813002572 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1033813002573 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1033813002574 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1033813002575 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1033813002576 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1033813002577 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1033813002578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813002579 Walker A/P-loop; other site 1033813002580 ATP binding site [chemical binding]; other site 1033813002581 Q-loop/lid; other site 1033813002582 ABC transporter signature motif; other site 1033813002583 Walker B; other site 1033813002584 D-loop; other site 1033813002585 H-loop/switch region; other site 1033813002586 TOBE domain; Region: TOBE_2; pfam08402 1033813002587 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1033813002588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813002589 dimer interface [polypeptide binding]; other site 1033813002590 conserved gate region; other site 1033813002591 putative PBP binding loops; other site 1033813002592 ABC-ATPase subunit interface; other site 1033813002593 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1033813002594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813002595 dimer interface [polypeptide binding]; other site 1033813002596 conserved gate region; other site 1033813002597 putative PBP binding loops; other site 1033813002598 ABC-ATPase subunit interface; other site 1033813002599 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1033813002600 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1033813002601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813002602 S-adenosylmethionine binding site [chemical binding]; other site 1033813002603 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1033813002604 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813002605 substrate binding pocket [chemical binding]; other site 1033813002606 membrane-bound complex binding site; other site 1033813002607 hinge residues; other site 1033813002608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813002609 dimer interface [polypeptide binding]; other site 1033813002610 conserved gate region; other site 1033813002611 putative PBP binding loops; other site 1033813002612 ABC-ATPase subunit interface; other site 1033813002613 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1033813002614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813002615 dimer interface [polypeptide binding]; other site 1033813002616 conserved gate region; other site 1033813002617 putative PBP binding loops; other site 1033813002618 ABC-ATPase subunit interface; other site 1033813002619 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1033813002620 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813002621 substrate binding pocket [chemical binding]; other site 1033813002622 membrane-bound complex binding site; other site 1033813002623 hinge residues; other site 1033813002624 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1033813002625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813002626 Walker A/P-loop; other site 1033813002627 ATP binding site [chemical binding]; other site 1033813002628 Q-loop/lid; other site 1033813002629 ABC transporter signature motif; other site 1033813002630 Walker B; other site 1033813002631 D-loop; other site 1033813002632 H-loop/switch region; other site 1033813002633 putative lipoprotein; Provisional; Region: PRK10533 1033813002634 hypothetical protein; Provisional; Region: PRK02877 1033813002635 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1033813002636 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1033813002637 amidase catalytic site [active] 1033813002638 Zn binding residues [ion binding]; other site 1033813002639 substrate binding site [chemical binding]; other site 1033813002640 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1033813002641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1033813002642 NAD(P) binding site [chemical binding]; other site 1033813002643 active site 1033813002644 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1033813002645 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1033813002646 putative NAD(P) binding site [chemical binding]; other site 1033813002647 putative active site [active] 1033813002648 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1033813002649 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1033813002650 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1033813002651 tetramer interface [polypeptide binding]; other site 1033813002652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813002653 catalytic residue [active] 1033813002654 pyruvate dehydrogenase; Provisional; Region: PRK09124 1033813002655 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1033813002656 PYR/PP interface [polypeptide binding]; other site 1033813002657 dimer interface [polypeptide binding]; other site 1033813002658 tetramer interface [polypeptide binding]; other site 1033813002659 TPP binding site [chemical binding]; other site 1033813002660 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1033813002661 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1033813002662 TPP-binding site [chemical binding]; other site 1033813002663 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1033813002664 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1033813002665 FAD binding pocket [chemical binding]; other site 1033813002666 FAD binding motif [chemical binding]; other site 1033813002667 phosphate binding motif [ion binding]; other site 1033813002668 beta-alpha-beta structure motif; other site 1033813002669 NAD binding pocket [chemical binding]; other site 1033813002670 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1033813002671 catalytic loop [active] 1033813002672 iron binding site [ion binding]; other site 1033813002673 hybrid cluster protein; Provisional; Region: PRK05290 1033813002674 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1033813002675 ACS interaction site; other site 1033813002676 CODH interaction site; other site 1033813002677 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1033813002678 hybrid metal cluster; other site 1033813002679 Predicted membrane protein [Function unknown]; Region: COG2431 1033813002680 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1033813002681 amphipathic channel; other site 1033813002682 Asn-Pro-Ala signature motifs; other site 1033813002683 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1033813002684 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1033813002685 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1033813002686 putative active site [active] 1033813002687 putative metal-binding site [ion binding]; other site 1033813002688 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1033813002689 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1033813002690 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813002691 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813002692 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1033813002693 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1033813002694 Walker A/P-loop; other site 1033813002695 ATP binding site [chemical binding]; other site 1033813002696 Q-loop/lid; other site 1033813002697 ABC transporter signature motif; other site 1033813002698 Walker B; other site 1033813002699 D-loop; other site 1033813002700 H-loop/switch region; other site 1033813002701 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1033813002702 FtsX-like permease family; Region: FtsX; pfam02687 1033813002703 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1033813002704 DNA-binding site [nucleotide binding]; DNA binding site 1033813002705 RNA-binding motif; other site 1033813002706 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1033813002707 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1033813002708 Clp amino terminal domain; Region: Clp_N; pfam02861 1033813002709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813002710 Walker A motif; other site 1033813002711 ATP binding site [chemical binding]; other site 1033813002712 Walker B motif; other site 1033813002713 arginine finger; other site 1033813002714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813002715 Walker A motif; other site 1033813002716 ATP binding site [chemical binding]; other site 1033813002717 Walker B motif; other site 1033813002718 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1033813002719 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1033813002720 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1033813002721 putative ligand binding site [chemical binding]; other site 1033813002722 NAD binding site [chemical binding]; other site 1033813002723 dimerization interface [polypeptide binding]; other site 1033813002724 catalytic site [active] 1033813002725 putative hydrolase; Validated; Region: PRK09248 1033813002726 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1033813002727 active site 1033813002728 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1033813002729 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1033813002730 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1033813002731 curli assembly protein CsgF; Provisional; Region: PRK10050 1033813002732 curli assembly protein CsgE; Provisional; Region: PRK10386 1033813002733 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1033813002734 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813002735 DNA binding residues [nucleotide binding] 1033813002736 dimerization interface [polypeptide binding]; other site 1033813002737 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1033813002738 rRNA binding site [nucleotide binding]; other site 1033813002739 predicted 30S ribosome binding site; other site 1033813002740 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1033813002741 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1033813002742 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033813002743 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1033813002744 Walker A/P-loop; other site 1033813002745 ATP binding site [chemical binding]; other site 1033813002746 Q-loop/lid; other site 1033813002747 ABC transporter signature motif; other site 1033813002748 Walker B; other site 1033813002749 D-loop; other site 1033813002750 H-loop/switch region; other site 1033813002751 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1033813002752 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033813002753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813002754 Walker A/P-loop; other site 1033813002755 ATP binding site [chemical binding]; other site 1033813002756 Q-loop/lid; other site 1033813002757 ABC transporter signature motif; other site 1033813002758 Walker B; other site 1033813002759 D-loop; other site 1033813002760 H-loop/switch region; other site 1033813002761 thioredoxin reductase; Provisional; Region: PRK10262 1033813002762 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1033813002763 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813002764 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1033813002765 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1033813002766 putative DNA binding site [nucleotide binding]; other site 1033813002767 putative Zn2+ binding site [ion binding]; other site 1033813002768 AsnC family; Region: AsnC_trans_reg; pfam01037 1033813002769 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1033813002770 DNA translocase FtsK; Provisional; Region: PRK10263 1033813002771 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1033813002772 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1033813002773 periplasmic chaperone LolA; Region: lolA; TIGR00547 1033813002774 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1033813002775 recombination factor protein RarA; Reviewed; Region: PRK13342 1033813002776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813002777 Walker A motif; other site 1033813002778 ATP binding site [chemical binding]; other site 1033813002779 Walker B motif; other site 1033813002780 arginine finger; other site 1033813002781 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1033813002782 seryl-tRNA synthetase; Provisional; Region: PRK05431 1033813002783 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1033813002784 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1033813002785 dimer interface [polypeptide binding]; other site 1033813002786 active site 1033813002787 motif 1; other site 1033813002788 motif 2; other site 1033813002789 motif 3; other site 1033813002790 Hok/gef family; Region: HOK_GEF; pfam01848 1033813002791 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 1033813002792 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1033813002793 tail protein; Provisional; Region: D; PHA02561 1033813002794 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1033813002795 Phage tail tube protein FII; Region: Phage_tube; cl01390 1033813002796 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1033813002797 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1033813002798 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1033813002799 Phage protein U [General function prediction only]; Region: COG3499 1033813002800 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1033813002801 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1033813002802 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1033813002803 DNA-binding interface [nucleotide binding]; DNA binding site 1033813002804 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1033813002805 Phage portal protein; Region: Phage_portal; pfam04860 1033813002806 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1033813002807 terminase ATPase subunit; Provisional; Region: P; PHA02535 1033813002808 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 1033813002809 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 1033813002810 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1033813002811 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1033813002812 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1033813002813 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1033813002814 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 1033813002815 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1033813002816 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 1033813002817 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 1033813002818 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1033813002819 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1033813002820 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1033813002821 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 1033813002822 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 1033813002823 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1033813002824 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1033813002825 Baseplate J-like protein; Region: Baseplate_J; cl01294 1033813002826 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1033813002827 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1033813002828 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1033813002829 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1033813002830 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1033813002831 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1033813002832 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1033813002833 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1033813002834 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1033813002835 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1033813002836 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1033813002837 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1033813002838 chain length determinant protein WzzB; Provisional; Region: PRK15471 1033813002839 Chain length determinant protein; Region: Wzz; pfam02706 1033813002840 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1033813002841 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1033813002842 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1033813002843 metal binding site [ion binding]; metal-binding site 1033813002844 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1033813002845 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1033813002846 substrate binding site [chemical binding]; other site 1033813002847 glutamase interaction surface [polypeptide binding]; other site 1033813002848 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1033813002849 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1033813002850 catalytic residues [active] 1033813002851 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1033813002852 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1033813002853 putative active site [active] 1033813002854 oxyanion strand; other site 1033813002855 catalytic triad [active] 1033813002856 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1033813002857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813002858 active site 1033813002859 motif I; other site 1033813002860 motif II; other site 1033813002861 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1033813002862 putative active site pocket [active] 1033813002863 4-fold oligomerization interface [polypeptide binding]; other site 1033813002864 metal binding residues [ion binding]; metal-binding site 1033813002865 3-fold/trimer interface [polypeptide binding]; other site 1033813002866 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1033813002867 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1033813002868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813002869 homodimer interface [polypeptide binding]; other site 1033813002870 catalytic residue [active] 1033813002871 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1033813002872 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1033813002873 NAD binding site [chemical binding]; other site 1033813002874 dimerization interface [polypeptide binding]; other site 1033813002875 product binding site; other site 1033813002876 substrate binding site [chemical binding]; other site 1033813002877 zinc binding site [ion binding]; other site 1033813002878 catalytic residues [active] 1033813002879 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1033813002880 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1033813002881 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1033813002882 antitoxin YefM; Provisional; Region: PRK11409 1033813002883 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1033813002884 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1033813002885 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1033813002886 putative NAD(P) binding site [chemical binding]; other site 1033813002887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813002888 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1033813002889 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1033813002890 dimerization interface [polypeptide binding]; other site 1033813002891 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1033813002892 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1033813002893 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1033813002894 exonuclease I; Provisional; Region: sbcB; PRK11779 1033813002895 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1033813002896 active site 1033813002897 catalytic site [active] 1033813002898 substrate binding site [chemical binding]; other site 1033813002899 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1033813002900 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1033813002901 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1033813002902 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1033813002903 DNA gyrase inhibitor; Provisional; Region: PRK10016 1033813002904 Predicted membrane protein [Function unknown]; Region: COG1289 1033813002905 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1033813002906 hypothetical protein; Provisional; Region: PRK05423 1033813002907 Integrase core domain; Region: rve; pfam00665 1033813002908 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 1033813002909 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1033813002910 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 1033813002911 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1033813002912 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1033813002913 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 1033813002914 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1033813002915 Mg binding site [ion binding]; other site 1033813002916 nucleotide binding site [chemical binding]; other site 1033813002917 putative protofilament interface [polypeptide binding]; other site 1033813002918 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1033813002919 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 1033813002920 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813002921 non-specific DNA binding site [nucleotide binding]; other site 1033813002922 salt bridge; other site 1033813002923 sequence-specific DNA binding site [nucleotide binding]; other site 1033813002924 integrase; Provisional; Region: int; PHA02601 1033813002925 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033813002926 active site 1033813002927 DNA binding site [nucleotide binding] 1033813002928 Int/Topo IB signature motif; other site 1033813002929 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1033813002930 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1033813002931 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1033813002932 putative [Fe4-S4] binding site [ion binding]; other site 1033813002933 putative molybdopterin cofactor binding site [chemical binding]; other site 1033813002934 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1033813002935 putative molybdopterin cofactor binding site; other site 1033813002936 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1033813002937 4Fe-4S binding domain; Region: Fer4; pfam00037 1033813002938 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1033813002939 Isochorismatase family; Region: Isochorismatase; pfam00857 1033813002940 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1033813002941 catalytic triad [active] 1033813002942 dimer interface [polypeptide binding]; other site 1033813002943 conserved cis-peptide bond; other site 1033813002944 putative MFS family transporter protein; Provisional; Region: PRK03633 1033813002945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813002946 putative substrate translocation pore; other site 1033813002947 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1033813002948 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813002949 FeS/SAM binding site; other site 1033813002950 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1033813002951 Pyruvate formate lyase 1; Region: PFL1; cd01678 1033813002952 coenzyme A binding site [chemical binding]; other site 1033813002953 active site 1033813002954 catalytic residues [active] 1033813002955 glycine loop; other site 1033813002956 formate transporter; Provisional; Region: PRK10805 1033813002957 uncharacterized domain; Region: TIGR00702 1033813002958 YcaO-like family; Region: YcaO; pfam02624 1033813002959 Predicted membrane protein [Function unknown]; Region: COG2323 1033813002960 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1033813002961 homodimer interface [polypeptide binding]; other site 1033813002962 substrate-cofactor binding pocket; other site 1033813002963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813002964 catalytic residue [active] 1033813002965 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1033813002966 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 1033813002967 hinge; other site 1033813002968 active site 1033813002969 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1033813002970 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1033813002971 DNA-binding interface [nucleotide binding]; DNA binding site 1033813002972 Phage Tail Collar Domain; Region: Collar; pfam07484 1033813002973 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1033813002974 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1033813002975 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1033813002976 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1033813002977 Phage Tail Collar Domain; Region: Collar; pfam07484 1033813002978 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 1033813002979 Baseplate J-like protein; Region: Baseplate_J; cl01294 1033813002980 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 1033813002981 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1033813002982 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1033813002983 Phage protein D [General function prediction only]; Region: COG3500 1033813002984 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1033813002985 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1033813002986 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1033813002987 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1033813002988 Phage tail tube protein FII; Region: Phage_tube; cl01390 1033813002989 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1033813002990 Gp37 protein; Region: Gp37; pfam09646 1033813002991 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 1033813002992 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 1033813002993 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1033813002994 Protein of unknown function (DUF935); Region: DUF935; pfam06074 1033813002995 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 1033813002996 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 1033813002997 phage lambda Rz-like lysis protein; Region: PHA00276 1033813002998 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1033813002999 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1033813003000 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1033813003001 catalytic residue [active] 1033813003002 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 1033813003003 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1033813003004 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 1033813003005 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1033813003006 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1033813003007 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1033813003008 DNA-binding interface [nucleotide binding]; DNA binding site 1033813003009 Integrase core domain; Region: rve; pfam00665 1033813003010 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1033813003011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813003012 Walker A/P-loop; other site 1033813003013 ATP binding site [chemical binding]; other site 1033813003014 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 1033813003015 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u2; cd11539 1033813003016 metal binding site [ion binding]; metal-binding site 1033813003017 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 1033813003018 Mor transcription activator family; Region: Mor; pfam08765 1033813003019 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1033813003020 cytidylate kinase; Provisional; Region: cmk; PRK00023 1033813003021 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1033813003022 CMP-binding site; other site 1033813003023 The sites determining sugar specificity; other site 1033813003024 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1033813003025 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1033813003026 RNA binding site [nucleotide binding]; other site 1033813003027 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1033813003028 RNA binding site [nucleotide binding]; other site 1033813003029 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1033813003030 RNA binding site [nucleotide binding]; other site 1033813003031 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1033813003032 RNA binding site [nucleotide binding]; other site 1033813003033 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1033813003034 RNA binding site [nucleotide binding]; other site 1033813003035 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1033813003036 IHF dimer interface [polypeptide binding]; other site 1033813003037 IHF - DNA interface [nucleotide binding]; other site 1033813003038 ComEC family competence protein; Provisional; Region: PRK11539 1033813003039 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1033813003040 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 1033813003041 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1033813003042 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1033813003043 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033813003044 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1033813003045 Walker A/P-loop; other site 1033813003046 ATP binding site [chemical binding]; other site 1033813003047 Q-loop/lid; other site 1033813003048 ABC transporter signature motif; other site 1033813003049 Walker B; other site 1033813003050 D-loop; other site 1033813003051 H-loop/switch region; other site 1033813003052 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1033813003053 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1033813003054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1033813003055 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1033813003056 hypothetical protein; Provisional; Region: PRK11827 1033813003057 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1033813003058 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1033813003059 Ligand binding site; other site 1033813003060 oligomer interface; other site 1033813003061 hypothetical protein; Provisional; Region: PRK10593 1033813003062 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1033813003063 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1033813003064 putative active site [active] 1033813003065 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1033813003066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813003067 S-adenosylmethionine binding site [chemical binding]; other site 1033813003068 condesin subunit F; Provisional; Region: PRK05260 1033813003069 condesin subunit E; Provisional; Region: PRK05256 1033813003070 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1033813003071 MukB N-terminal; Region: MukB; pfam04310 1033813003072 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1033813003073 murein L,D-transpeptidase; Provisional; Region: PRK10594 1033813003074 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1033813003075 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1033813003076 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1033813003077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1033813003078 Peptidase M15; Region: Peptidase_M15_3; cl01194 1033813003079 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1033813003080 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1033813003081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1033813003082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813003083 homodimer interface [polypeptide binding]; other site 1033813003084 catalytic residue [active] 1033813003085 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1033813003086 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1033813003087 trimer interface [polypeptide binding]; other site 1033813003088 eyelet of channel; other site 1033813003089 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1033813003090 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1033813003091 putative dimer interface [polypeptide binding]; other site 1033813003092 putative anticodon binding site; other site 1033813003093 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1033813003094 homodimer interface [polypeptide binding]; other site 1033813003095 motif 1; other site 1033813003096 motif 2; other site 1033813003097 active site 1033813003098 motif 3; other site 1033813003099 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1033813003100 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1033813003101 active site 1033813003102 aminopeptidase N; Provisional; Region: pepN; PRK14015 1033813003103 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1033813003104 active site 1033813003105 Zn binding site [ion binding]; other site 1033813003106 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1033813003107 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1033813003108 Walker A/P-loop; other site 1033813003109 ATP binding site [chemical binding]; other site 1033813003110 Q-loop/lid; other site 1033813003111 ABC transporter signature motif; other site 1033813003112 Walker B; other site 1033813003113 D-loop; other site 1033813003114 H-loop/switch region; other site 1033813003115 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1033813003116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813003117 dimer interface [polypeptide binding]; other site 1033813003118 conserved gate region; other site 1033813003119 putative PBP binding loops; other site 1033813003120 ABC-ATPase subunit interface; other site 1033813003121 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1033813003122 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1033813003123 active site 1033813003124 dimer interface [polypeptide binding]; other site 1033813003125 non-prolyl cis peptide bond; other site 1033813003126 insertion regions; other site 1033813003127 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813003128 substrate binding pocket [chemical binding]; other site 1033813003129 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1033813003130 membrane-bound complex binding site; other site 1033813003131 hinge residues; other site 1033813003132 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1033813003133 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1033813003134 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1033813003135 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1033813003136 quinone interaction residues [chemical binding]; other site 1033813003137 active site 1033813003138 catalytic residues [active] 1033813003139 FMN binding site [chemical binding]; other site 1033813003140 substrate binding site [chemical binding]; other site 1033813003141 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1033813003142 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1033813003143 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1033813003144 MOSC domain; Region: MOSC; pfam03473 1033813003145 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1033813003146 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1033813003147 catalytic loop [active] 1033813003148 iron binding site [ion binding]; other site 1033813003149 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1033813003150 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1033813003151 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1033813003152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813003153 S-adenosylmethionine binding site [chemical binding]; other site 1033813003154 ABC transporter ATPase component; Reviewed; Region: PRK11147 1033813003155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813003156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813003157 Walker A/P-loop; other site 1033813003158 Walker A/P-loop; other site 1033813003159 ATP binding site [chemical binding]; other site 1033813003160 ATP binding site [chemical binding]; other site 1033813003161 Q-loop/lid; other site 1033813003162 Q-loop/lid; other site 1033813003163 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033813003164 ABC transporter signature motif; other site 1033813003165 Walker B; other site 1033813003166 D-loop; other site 1033813003167 ABC transporter; Region: ABC_tran_2; pfam12848 1033813003168 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033813003169 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1033813003170 Paraquat-inducible protein A; Region: PqiA; pfam04403 1033813003171 Paraquat-inducible protein A; Region: PqiA; pfam04403 1033813003172 paraquat-inducible protein B; Provisional; Region: PRK10807 1033813003173 mce related protein; Region: MCE; pfam02470 1033813003174 mce related protein; Region: MCE; pfam02470 1033813003175 mce related protein; Region: MCE; pfam02470 1033813003176 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 1033813003177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1033813003178 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1033813003179 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1033813003180 active site 1 [active] 1033813003181 dimer interface [polypeptide binding]; other site 1033813003182 active site 2 [active] 1033813003183 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1033813003184 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1033813003185 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1033813003186 outer membrane protein A; Reviewed; Region: PRK10808 1033813003187 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1033813003188 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1033813003189 ligand binding site [chemical binding]; other site 1033813003190 SOS cell division inhibitor; Provisional; Region: PRK10595 1033813003191 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1033813003192 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1033813003193 TIGR01666 family membrane protein; Region: YCCS 1033813003194 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1033813003195 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1033813003196 Predicted membrane protein [Function unknown]; Region: COG3304 1033813003197 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1033813003198 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1033813003199 DNA helicase IV; Provisional; Region: helD; PRK11054 1033813003200 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1033813003201 Part of AAA domain; Region: AAA_19; pfam13245 1033813003202 Family description; Region: UvrD_C_2; pfam13538 1033813003203 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1033813003204 active site 1033813003205 dimer interfaces [polypeptide binding]; other site 1033813003206 catalytic residues [active] 1033813003207 hypothetical protein; Provisional; Region: PRK03641 1033813003208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1033813003209 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1033813003210 heat shock protein HspQ; Provisional; Region: PRK14129 1033813003211 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1033813003212 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1033813003213 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1033813003214 putative RNA binding site [nucleotide binding]; other site 1033813003215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813003216 S-adenosylmethionine binding site [chemical binding]; other site 1033813003217 Acylphosphatase; Region: Acylphosphatase; cl00551 1033813003218 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1033813003219 sulfur transfer protein TusE; Provisional; Region: PRK11508 1033813003220 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1033813003221 YccA-like proteins; Region: YccA_like; cd10433 1033813003222 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 1033813003223 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1033813003224 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1033813003225 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1033813003226 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1033813003227 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 1033813003228 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1033813003229 putative substrate-binding site; other site 1033813003230 nickel binding site [ion binding]; other site 1033813003231 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1033813003232 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1033813003233 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 1033813003234 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1033813003235 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 1033813003236 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1033813003237 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1033813003238 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1033813003239 catalytic core [active] 1033813003240 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1033813003241 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1033813003242 DNA-binding site [nucleotide binding]; DNA binding site 1033813003243 RNA-binding motif; other site 1033813003244 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1033813003245 DNA-binding site [nucleotide binding]; DNA binding site 1033813003246 RNA-binding motif; other site 1033813003247 GnsA/GnsB family; Region: GnsAB; pfam08178 1033813003248 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1033813003249 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1033813003250 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 1033813003251 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1033813003252 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1033813003253 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1033813003254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1033813003255 dimerization interface [polypeptide binding]; other site 1033813003256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813003257 dimer interface [polypeptide binding]; other site 1033813003258 phosphorylation site [posttranslational modification] 1033813003259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813003260 ATP binding site [chemical binding]; other site 1033813003261 Mg2+ binding site [ion binding]; other site 1033813003262 G-X-G motif; other site 1033813003263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813003264 active site 1033813003265 phosphorylation site [posttranslational modification] 1033813003266 intermolecular recognition site; other site 1033813003267 dimerization interface [polypeptide binding]; other site 1033813003268 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1033813003269 putative binding surface; other site 1033813003270 active site 1033813003271 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 1033813003272 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 1033813003273 putative ligand binding site [chemical binding]; other site 1033813003274 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1033813003275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813003276 active site 1033813003277 phosphorylation site [posttranslational modification] 1033813003278 intermolecular recognition site; other site 1033813003279 dimerization interface [polypeptide binding]; other site 1033813003280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813003281 DNA binding site [nucleotide binding] 1033813003282 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 1033813003283 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1033813003284 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1033813003285 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1033813003286 molybdopterin cofactor binding site [chemical binding]; other site 1033813003287 substrate binding site [chemical binding]; other site 1033813003288 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1033813003289 molybdopterin cofactor binding site; other site 1033813003290 chaperone protein TorD; Validated; Region: torD; PRK04976 1033813003291 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1033813003292 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1033813003293 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1033813003294 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1033813003295 HSP70 interaction site [polypeptide binding]; other site 1033813003296 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1033813003297 substrate binding site [polypeptide binding]; other site 1033813003298 dimer interface [polypeptide binding]; other site 1033813003299 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1033813003300 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1033813003301 catalytic core [active] 1033813003302 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1033813003303 hypothetical protein; Provisional; Region: PRK10174 1033813003304 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1033813003305 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1033813003306 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1033813003307 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 1033813003308 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1033813003309 putative FMN binding site [chemical binding]; other site 1033813003310 pyrimidine utilization protein D; Region: RutD; TIGR03611 1033813003311 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1033813003312 homotrimer interaction site [polypeptide binding]; other site 1033813003313 putative active site [active] 1033813003314 Isochorismatase family; Region: Isochorismatase; pfam00857 1033813003315 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1033813003316 catalytic triad [active] 1033813003317 conserved cis-peptide bond; other site 1033813003318 pyrimidine utilization protein A; Region: RutA; TIGR03612 1033813003319 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1033813003320 active site 1033813003321 dimer interface [polypeptide binding]; other site 1033813003322 non-prolyl cis peptide bond; other site 1033813003323 insertion regions; other site 1033813003324 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1033813003325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813003326 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1033813003327 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1033813003328 Predicted transcriptional regulator [Transcription]; Region: COG3905 1033813003329 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1033813003330 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1033813003331 Glutamate binding site [chemical binding]; other site 1033813003332 NAD binding site [chemical binding]; other site 1033813003333 catalytic residues [active] 1033813003334 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1033813003335 Na binding site [ion binding]; other site 1033813003336 FTR1 family protein; Region: TIGR00145 1033813003337 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1033813003338 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1033813003339 Imelysin; Region: Peptidase_M75; pfam09375 1033813003340 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1033813003341 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1033813003342 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1033813003343 hypothetical protein; Provisional; Region: PRK10536 1033813003344 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 1033813003345 N-glycosyltransferase; Provisional; Region: PRK11204 1033813003346 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1033813003347 DXD motif; other site 1033813003348 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1033813003349 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 1033813003350 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1033813003351 putative active site [active] 1033813003352 putative metal binding site [ion binding]; other site 1033813003353 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 1033813003354 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1033813003355 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1033813003356 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1033813003357 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 1033813003358 Fimbrial protein; Region: Fimbrial; cl01416 1033813003359 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1033813003360 putative ADP-ribose binding site [chemical binding]; other site 1033813003361 putative active site [active] 1033813003362 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1033813003363 PLD-like domain; Region: PLDc_2; pfam13091 1033813003364 putative active site [active] 1033813003365 catalytic site [active] 1033813003366 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1033813003367 PLD-like domain; Region: PLDc_2; pfam13091 1033813003368 putative active site [active] 1033813003369 catalytic site [active] 1033813003370 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1033813003371 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1033813003372 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1033813003373 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1033813003374 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1033813003375 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1033813003376 Ligand binding site; other site 1033813003377 DXD motif; other site 1033813003378 lipoprotein; Provisional; Region: PRK10175 1033813003379 secY/secA suppressor protein; Provisional; Region: PRK11467 1033813003380 drug efflux system protein MdtG; Provisional; Region: PRK09874 1033813003381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813003382 putative substrate translocation pore; other site 1033813003383 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1033813003384 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1033813003385 putative acyl-acceptor binding pocket; other site 1033813003386 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1033813003387 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1033813003388 active site residue [active] 1033813003389 hypothetical protein; Provisional; Region: PRK03757 1033813003390 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1033813003391 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 1033813003392 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1033813003393 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1033813003394 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1033813003395 DNA damage-inducible protein I; Provisional; Region: PRK10597 1033813003396 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1033813003397 active site 1033813003398 dimer interface [polypeptide binding]; other site 1033813003399 substrate binding pocket [chemical binding]; other site 1033813003400 lipoprotein; Provisional; Region: PRK10598 1033813003401 glutaredoxin 2; Provisional; Region: PRK10387 1033813003402 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1033813003403 C-terminal domain interface [polypeptide binding]; other site 1033813003404 GSH binding site (G-site) [chemical binding]; other site 1033813003405 catalytic residues [active] 1033813003406 putative dimer interface [polypeptide binding]; other site 1033813003407 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1033813003408 N-terminal domain interface [polypeptide binding]; other site 1033813003409 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1033813003410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813003411 putative substrate translocation pore; other site 1033813003412 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1033813003413 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1033813003414 hypothetical protein; Provisional; Region: PRK11239 1033813003415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1033813003416 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1033813003417 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1033813003418 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1033813003419 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1033813003420 MviN-like protein; Region: MVIN; pfam03023 1033813003421 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 1033813003422 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1033813003423 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 1033813003424 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1033813003425 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1033813003426 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1033813003427 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1033813003428 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1033813003429 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1033813003430 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1033813003431 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1033813003432 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1033813003433 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1033813003434 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1033813003435 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1033813003436 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1033813003437 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1033813003438 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 1033813003439 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1033813003440 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1033813003441 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1033813003442 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1033813003443 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1033813003444 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1033813003445 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1033813003446 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1033813003447 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1033813003448 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1033813003449 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1033813003450 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1033813003451 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1033813003452 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1033813003453 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1033813003454 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1033813003455 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1033813003456 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1033813003457 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1033813003458 homodimer interface [polypeptide binding]; other site 1033813003459 oligonucleotide binding site [chemical binding]; other site 1033813003460 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1033813003461 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1033813003462 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033813003463 RNA binding surface [nucleotide binding]; other site 1033813003464 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1033813003465 active site 1033813003466 Maf-like protein; Region: Maf; pfam02545 1033813003467 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1033813003468 active site 1033813003469 dimer interface [polypeptide binding]; other site 1033813003470 hypothetical protein; Provisional; Region: PRK11193 1033813003471 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1033813003472 putative phosphate acyltransferase; Provisional; Region: PRK05331 1033813003473 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1033813003474 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1033813003475 dimer interface [polypeptide binding]; other site 1033813003476 active site 1033813003477 CoA binding pocket [chemical binding]; other site 1033813003478 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1033813003479 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1033813003480 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1033813003481 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1033813003482 NAD(P) binding site [chemical binding]; other site 1033813003483 homotetramer interface [polypeptide binding]; other site 1033813003484 homodimer interface [polypeptide binding]; other site 1033813003485 active site 1033813003486 acyl carrier protein; Provisional; Region: acpP; PRK00982 1033813003487 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1033813003488 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1033813003489 dimer interface [polypeptide binding]; other site 1033813003490 active site 1033813003491 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1033813003492 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1033813003493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813003494 catalytic residue [active] 1033813003495 conserved hypothetical protein, YceG family; Region: TIGR00247 1033813003496 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1033813003497 dimerization interface [polypeptide binding]; other site 1033813003498 thymidylate kinase; Validated; Region: tmk; PRK00698 1033813003499 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1033813003500 TMP-binding site; other site 1033813003501 ATP-binding site [chemical binding]; other site 1033813003502 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1033813003503 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1033813003504 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1033813003505 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1033813003506 active site 1033813003507 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1033813003508 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1033813003509 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1033813003510 active site turn [active] 1033813003511 phosphorylation site [posttranslational modification] 1033813003512 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1033813003513 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813003514 N-terminal plug; other site 1033813003515 ligand-binding site [chemical binding]; other site 1033813003516 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1033813003517 nucleotide binding site/active site [active] 1033813003518 HIT family signature motif; other site 1033813003519 catalytic residue [active] 1033813003520 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1033813003521 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1033813003522 putative dimer interface [polypeptide binding]; other site 1033813003523 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1033813003524 thiamine kinase; Region: ycfN_thiK; TIGR02721 1033813003525 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1033813003526 active site 1033813003527 substrate binding site [chemical binding]; other site 1033813003528 ATP binding site [chemical binding]; other site 1033813003529 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1033813003530 beta-hexosaminidase; Provisional; Region: PRK05337 1033813003531 hypothetical protein; Provisional; Region: PRK04940 1033813003532 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1033813003533 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813003534 hypothetical protein; Provisional; Region: PRK11280 1033813003535 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1033813003536 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813003537 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1033813003538 L,D-transpeptidase; Provisional; Region: PRK10260 1033813003539 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1033813003540 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1033813003541 transcription-repair coupling factor; Provisional; Region: PRK10689 1033813003542 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1033813003543 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033813003544 ATP binding site [chemical binding]; other site 1033813003545 putative Mg++ binding site [ion binding]; other site 1033813003546 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813003547 nucleotide binding region [chemical binding]; other site 1033813003548 ATP-binding site [chemical binding]; other site 1033813003549 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1033813003550 Predicted membrane protein [Function unknown]; Region: COG4763 1033813003551 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1033813003552 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1033813003553 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1033813003554 FtsX-like permease family; Region: FtsX; pfam02687 1033813003555 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1033813003556 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1033813003557 Walker A/P-loop; other site 1033813003558 ATP binding site [chemical binding]; other site 1033813003559 Q-loop/lid; other site 1033813003560 ABC transporter signature motif; other site 1033813003561 Walker B; other site 1033813003562 D-loop; other site 1033813003563 H-loop/switch region; other site 1033813003564 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1033813003565 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1033813003566 FtsX-like permease family; Region: FtsX; pfam02687 1033813003567 fructokinase; Reviewed; Region: PRK09557 1033813003568 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033813003569 nucleotide binding site [chemical binding]; other site 1033813003570 NAD-dependent deacetylase; Provisional; Region: PRK00481 1033813003571 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1033813003572 NAD+ binding site [chemical binding]; other site 1033813003573 substrate binding site [chemical binding]; other site 1033813003574 Zn binding site [ion binding]; other site 1033813003575 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1033813003576 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1033813003577 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1033813003578 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1033813003579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813003580 dimer interface [polypeptide binding]; other site 1033813003581 conserved gate region; other site 1033813003582 putative PBP binding loops; other site 1033813003583 ABC-ATPase subunit interface; other site 1033813003584 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1033813003585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813003586 dimer interface [polypeptide binding]; other site 1033813003587 conserved gate region; other site 1033813003588 putative PBP binding loops; other site 1033813003589 ABC-ATPase subunit interface; other site 1033813003590 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1033813003591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813003592 Walker A/P-loop; other site 1033813003593 ATP binding site [chemical binding]; other site 1033813003594 Q-loop/lid; other site 1033813003595 ABC transporter signature motif; other site 1033813003596 Walker B; other site 1033813003597 D-loop; other site 1033813003598 H-loop/switch region; other site 1033813003599 TOBE domain; Region: TOBE_2; pfam08402 1033813003600 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1033813003601 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1033813003602 metal binding site [ion binding]; metal-binding site 1033813003603 dimer interface [polypeptide binding]; other site 1033813003604 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1033813003605 Cupin-like domain; Region: Cupin_8; pfam13621 1033813003606 sensor protein PhoQ; Provisional; Region: PRK10815 1033813003607 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1033813003608 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1033813003609 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1033813003610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813003611 ATP binding site [chemical binding]; other site 1033813003612 Mg2+ binding site [ion binding]; other site 1033813003613 G-X-G motif; other site 1033813003614 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1033813003615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813003616 active site 1033813003617 phosphorylation site [posttranslational modification] 1033813003618 intermolecular recognition site; other site 1033813003619 dimerization interface [polypeptide binding]; other site 1033813003620 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813003621 DNA binding site [nucleotide binding] 1033813003622 adenylosuccinate lyase; Provisional; Region: PRK09285 1033813003623 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1033813003624 tetramer interface [polypeptide binding]; other site 1033813003625 active site 1033813003626 putative lysogenization regulator; Reviewed; Region: PRK00218 1033813003627 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1033813003628 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1033813003629 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1033813003630 nudix motif; other site 1033813003631 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1033813003632 pseudouridine synthase; Region: TIGR00093 1033813003633 probable active site [active] 1033813003634 isocitrate dehydrogenase; Validated; Region: PRK07362 1033813003635 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1033813003636 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1033813003637 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1033813003638 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1033813003639 dimer interface [polypeptide binding]; other site 1033813003640 active site 1033813003641 Int/Topo IB signature motif; other site 1033813003642 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1033813003643 DksA-like zinc finger domain containing protein; Region: PHA00080 1033813003644 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 1033813003645 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1033813003646 phage recombination protein Bet; Region: bet_lambda; TIGR01913 1033813003647 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 1033813003648 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 1033813003649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813003650 non-specific DNA binding site [nucleotide binding]; other site 1033813003651 salt bridge; other site 1033813003652 Predicted transcriptional regulator [Transcription]; Region: COG2932 1033813003653 sequence-specific DNA binding site [nucleotide binding]; other site 1033813003654 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1033813003655 Catalytic site [active] 1033813003656 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1033813003657 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1033813003658 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1033813003659 Replication protein P; Region: Phage_lambda_P; pfam06992 1033813003660 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1033813003661 hypothetical protein; Provisional; Region: PRK09741 1033813003662 prophage protein NinE; Provisional; Region: PRK09689 1033813003663 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 1033813003664 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 1033813003665 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 1033813003666 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 1033813003667 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1033813003668 catalytic residue [active] 1033813003669 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1033813003670 Bor protein; Region: Lambda_Bor; pfam06291 1033813003671 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1033813003672 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 1033813003673 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1033813003674 gpW; Region: gpW; pfam02831 1033813003675 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1033813003676 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1033813003677 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1033813003678 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1033813003679 tandem repeat interface [polypeptide binding]; other site 1033813003680 oligomer interface [polypeptide binding]; other site 1033813003681 active site residues [active] 1033813003682 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1033813003683 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1033813003684 DNA packaging protein FI; Region: Packaging_FI; pfam14000 1033813003685 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 1033813003686 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1033813003687 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1033813003688 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1033813003689 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1033813003690 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 1033813003691 Minor tail protein T; Region: Phage_tail_T; pfam06223 1033813003692 Phage-related minor tail protein [Function unknown]; Region: COG5281 1033813003693 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1033813003694 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1033813003695 Phage-related protein [Function unknown]; Region: COG4718 1033813003696 Phage-related protein [Function unknown]; Region: gp18; COG4672 1033813003697 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1033813003698 MPN+ (JAMM) motif; other site 1033813003699 Zinc-binding site [ion binding]; other site 1033813003700 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 1033813003701 Lysis protein S; Region: Lysis_S; pfam04971 1033813003702 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 1033813003703 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1033813003704 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1033813003705 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1033813003706 catalytic residues [active] 1033813003707 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1033813003708 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 1033813003709 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1033813003710 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1033813003711 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1033813003712 Phage capsid family; Region: Phage_capsid; pfam05065 1033813003713 Phage-related protein [Function unknown]; Region: COG4695 1033813003714 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1033813003715 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1033813003716 zinc binding site [ion binding]; other site 1033813003717 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 1033813003718 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 1033813003719 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1033813003720 Immunoglobulin domain; Region: Ig_3; pfam13927 1033813003721 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 1033813003722 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 1033813003723 Phage-related minor tail protein [Function unknown]; Region: COG5281 1033813003724 tape measure domain; Region: tape_meas_nterm; TIGR02675 1033813003725 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 1033813003726 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1033813003727 Phage-related protein [Function unknown]; Region: COG4718 1033813003728 Phage-related protein [Function unknown]; Region: gp18; COG4672 1033813003729 Phage-related protein, tail component [Function unknown]; Region: COG4733 1033813003730 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1033813003731 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1033813003732 Interdomain contacts; other site 1033813003733 Cytokine receptor motif; other site 1033813003734 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1033813003735 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1033813003736 active site 1033813003737 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1033813003738 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1033813003739 Phage portal protein; Region: Phage_portal; pfam04860 1033813003740 Phage-related protein [Function unknown]; Region: COG4695 1033813003741 Phage head maturation protease [General function prediction only]; Region: COG3740 1033813003742 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1033813003743 Phage capsid family; Region: Phage_capsid; pfam05065 1033813003744 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1033813003745 oligomerization interface [polypeptide binding]; other site 1033813003746 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 1033813003747 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 1033813003748 Immunoglobulin domain; Region: Ig_2; pfam13895 1033813003749 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 1033813003750 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 1033813003751 Phage-related minor tail protein [Function unknown]; Region: COG5281 1033813003752 tape measure domain; Region: tape_meas_nterm; TIGR02675 1033813003753 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 1033813003754 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1033813003755 Phage minor tail protein; Region: Phage_min_tail; pfam05939 1033813003756 Phage-related protein [Function unknown]; Region: gp18; COG4672 1033813003757 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1033813003758 MPN+ (JAMM) motif; other site 1033813003759 Zinc-binding site [ion binding]; other site 1033813003760 Phage-related protein, tail component [Function unknown]; Region: COG4723 1033813003761 Phage-related protein, tail component [Function unknown]; Region: COG4733 1033813003762 Phage-related protein, tail component [Function unknown]; Region: COG4723 1033813003763 Phage-related protein, tail component [Function unknown]; Region: COG4733 1033813003764 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1033813003765 Phage-related protein, tail component [Function unknown]; Region: COG4733 1033813003766 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1033813003767 Phage-related protein, tail component [Function unknown]; Region: COG4733 1033813003768 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1033813003769 Interdomain contacts; other site 1033813003770 Cytokine receptor motif; other site 1033813003771 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1033813003772 Fibronectin type III protein; Region: DUF3672; pfam12421 1033813003773 Fibronectin type III protein; Region: DUF3672; pfam12421 1033813003774 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 1033813003775 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1033813003776 Fibronectin type III protein; Region: DUF3672; pfam12421 1033813003777 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1033813003778 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1033813003779 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813003780 ABC-ATPase subunit interface; other site 1033813003781 dimer interface [polypeptide binding]; other site 1033813003782 putative PBP binding regions; other site 1033813003783 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1033813003784 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813003785 ABC-ATPase subunit interface; other site 1033813003786 dimer interface [polypeptide binding]; other site 1033813003787 putative PBP binding regions; other site 1033813003788 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1033813003789 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1033813003790 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1033813003791 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1033813003792 metal binding site [ion binding]; metal-binding site 1033813003793 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1033813003794 Autotransporter beta-domain; Region: Autotransporter; cl17461 1033813003795 Autotransporter beta-domain; Region: Autotransporter; smart00869 1033813003796 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1033813003797 cell division inhibitor MinD; Provisional; Region: PRK10818 1033813003798 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1033813003799 Switch I; other site 1033813003800 Switch II; other site 1033813003801 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1033813003802 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1033813003803 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1033813003804 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1033813003805 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1033813003806 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1033813003807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1033813003808 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1033813003809 hypothetical protein; Provisional; Region: PRK10691 1033813003810 hypothetical protein; Provisional; Region: PRK05170 1033813003811 Haemolysin E (HlyE); Region: HlyE; cl11627 1033813003812 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1033813003813 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1033813003814 Catalytic site [active] 1033813003815 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1033813003816 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1033813003817 active site 1033813003818 DNA binding site [nucleotide binding] 1033813003819 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1033813003820 disulfide bond formation protein B; Provisional; Region: PRK01749 1033813003821 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1033813003822 transmembrane helices; other site 1033813003823 fatty acid metabolism regulator; Provisional; Region: PRK04984 1033813003824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813003825 DNA-binding site [nucleotide binding]; DNA binding site 1033813003826 FadR C-terminal domain; Region: FadR_C; pfam07840 1033813003827 SpoVR family protein; Provisional; Region: PRK11767 1033813003828 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1033813003829 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1033813003830 alanine racemase; Reviewed; Region: dadX; PRK03646 1033813003831 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1033813003832 active site 1033813003833 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1033813003834 substrate binding site [chemical binding]; other site 1033813003835 catalytic residues [active] 1033813003836 dimer interface [polypeptide binding]; other site 1033813003837 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1033813003838 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1033813003839 TrkA-C domain; Region: TrkA_C; pfam02080 1033813003840 Transporter associated domain; Region: CorC_HlyC; smart01091 1033813003841 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1033813003842 dimer interface [polypeptide binding]; other site 1033813003843 catalytic triad [active] 1033813003844 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1033813003845 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1033813003846 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1033813003847 catalytic residue [active] 1033813003848 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1033813003849 Flagellar regulator YcgR; Region: YcgR; pfam07317 1033813003850 PilZ domain; Region: PilZ; pfam07238 1033813003851 hypothetical protein; Provisional; Region: PRK10457 1033813003852 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813003853 N-terminal plug; other site 1033813003854 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1033813003855 ligand-binding site [chemical binding]; other site 1033813003856 molybdenum transport protein ModD; Provisional; Region: PRK06096 1033813003857 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 1033813003858 dimerization interface [polypeptide binding]; other site 1033813003859 active site 1033813003860 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1033813003861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813003862 S-adenosylmethionine binding site [chemical binding]; other site 1033813003863 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1033813003864 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1033813003865 Walker A/P-loop; other site 1033813003866 ATP binding site [chemical binding]; other site 1033813003867 Q-loop/lid; other site 1033813003868 ABC transporter signature motif; other site 1033813003869 Walker B; other site 1033813003870 D-loop; other site 1033813003871 H-loop/switch region; other site 1033813003872 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1033813003873 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813003874 ABC-ATPase subunit interface; other site 1033813003875 dimer interface [polypeptide binding]; other site 1033813003876 putative PBP binding regions; other site 1033813003877 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1033813003878 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 1033813003879 putative metal binding site [ion binding]; other site 1033813003880 trehalase; Provisional; Region: treA; PRK13271 1033813003881 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1033813003882 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1033813003883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 1033813003884 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1033813003885 dimerization domain swap beta strand [polypeptide binding]; other site 1033813003886 regulatory protein interface [polypeptide binding]; other site 1033813003887 active site 1033813003888 regulatory phosphorylation site [posttranslational modification]; other site 1033813003889 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1033813003890 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1033813003891 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 1033813003892 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1033813003893 Dak1 domain; Region: Dak1; pfam02733 1033813003894 PAS fold; Region: PAS; pfam00989 1033813003895 PAS domain; Region: PAS; smart00091 1033813003896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813003897 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1033813003898 Walker A motif; other site 1033813003899 ATP binding site [chemical binding]; other site 1033813003900 Walker B motif; other site 1033813003901 arginine finger; other site 1033813003902 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 1033813003903 Protein of unknown function (DUF2787); Region: DUF2787; pfam10980 1033813003904 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1033813003905 MPN+ (JAMM) motif; other site 1033813003906 Zinc-binding site [ion binding]; other site 1033813003907 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1033813003908 active site 1033813003909 catalytic residues [active] 1033813003910 DNA binding site [nucleotide binding] 1033813003911 Int/Topo IB signature motif; other site 1033813003912 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1033813003913 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1033813003914 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1033813003915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1033813003916 Integrase core domain; Region: rve; pfam00665 1033813003917 Integrase core domain; Region: rve_3; pfam13683 1033813003918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1033813003919 Transposase; Region: HTH_Tnp_1; pfam01527 1033813003920 integrase; Provisional; Region: PRK09692 1033813003921 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1033813003922 active site 1033813003923 Int/Topo IB signature motif; other site 1033813003924 GTP-binding protein YchF; Reviewed; Region: PRK09601 1033813003925 YchF GTPase; Region: YchF; cd01900 1033813003926 G1 box; other site 1033813003927 GTP/Mg2+ binding site [chemical binding]; other site 1033813003928 Switch I region; other site 1033813003929 G2 box; other site 1033813003930 Switch II region; other site 1033813003931 G3 box; other site 1033813003932 G4 box; other site 1033813003933 G5 box; other site 1033813003934 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1033813003935 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1033813003936 putative active site [active] 1033813003937 catalytic residue [active] 1033813003938 hypothetical protein; Provisional; Region: PRK10692 1033813003939 putative transporter; Provisional; Region: PRK11660 1033813003940 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1033813003941 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1033813003942 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1033813003943 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1033813003944 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1033813003945 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033813003946 active site 1033813003947 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1033813003948 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1033813003949 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1033813003950 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 1033813003951 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1033813003952 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1033813003953 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1033813003954 tRNA; other site 1033813003955 putative tRNA binding site [nucleotide binding]; other site 1033813003956 putative NADP binding site [chemical binding]; other site 1033813003957 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1033813003958 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1033813003959 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1033813003960 RF-1 domain; Region: RF-1; pfam00472 1033813003961 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1033813003962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813003963 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 1033813003964 hypothetical protein; Provisional; Region: PRK10941 1033813003965 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1033813003966 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1033813003967 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1033813003968 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1033813003969 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1033813003970 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1033813003971 cation transport regulator; Reviewed; Region: chaB; PRK09582 1033813003972 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1033813003973 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1033813003974 putative active site pocket [active] 1033813003975 dimerization interface [polypeptide binding]; other site 1033813003976 putative catalytic residue [active] 1033813003977 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1033813003978 putative invasin; Provisional; Region: PRK10177 1033813003979 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1033813003980 transcriptional regulator NarL; Provisional; Region: PRK10651 1033813003981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813003982 active site 1033813003983 phosphorylation site [posttranslational modification] 1033813003984 intermolecular recognition site; other site 1033813003985 dimerization interface [polypeptide binding]; other site 1033813003986 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813003987 DNA binding residues [nucleotide binding] 1033813003988 dimerization interface [polypeptide binding]; other site 1033813003989 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1033813003990 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1033813003991 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033813003992 dimerization interface [polypeptide binding]; other site 1033813003993 Histidine kinase; Region: HisKA_3; pfam07730 1033813003994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813003995 ATP binding site [chemical binding]; other site 1033813003996 Mg2+ binding site [ion binding]; other site 1033813003997 G-X-G motif; other site 1033813003998 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1033813003999 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1033813004000 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1033813004001 [4Fe-4S] binding site [ion binding]; other site 1033813004002 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813004003 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813004004 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813004005 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1033813004006 molybdopterin cofactor binding site; other site 1033813004007 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1033813004008 4Fe-4S binding domain; Region: Fer4; cl02805 1033813004009 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1033813004010 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1033813004011 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 1033813004012 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1033813004013 dimer interface [polypeptide binding]; other site 1033813004014 active site 1033813004015 CoA binding pocket [chemical binding]; other site 1033813004016 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1033813004017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1033813004018 NAD(P) binding site [chemical binding]; other site 1033813004019 active site 1033813004020 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1033813004021 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1033813004022 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 1033813004023 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1033813004024 active site 1033813004025 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1033813004026 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1033813004027 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1033813004028 putative di-iron ligands [ion binding]; other site 1033813004029 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1033813004030 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1033813004031 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1033813004032 putative active site [active] 1033813004033 putative substrate binding site [chemical binding]; other site 1033813004034 putative cosubstrate binding site; other site 1033813004035 catalytic site [active] 1033813004036 hypothetical protein; Provisional; Region: PRK01617 1033813004037 hypothetical protein; Provisional; Region: PRK10279 1033813004038 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1033813004039 active site 1033813004040 nucleophile elbow; other site 1033813004041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813004042 active site 1033813004043 response regulator of RpoS; Provisional; Region: PRK10693 1033813004044 phosphorylation site [posttranslational modification] 1033813004045 intermolecular recognition site; other site 1033813004046 dimerization interface [polypeptide binding]; other site 1033813004047 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1033813004048 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1033813004049 active site 1033813004050 tetramer interface; other site 1033813004051 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1033813004052 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1033813004053 thymidine kinase; Provisional; Region: PRK04296 1033813004054 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1033813004055 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1033813004056 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1033813004057 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1033813004058 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1033813004059 putative catalytic cysteine [active] 1033813004060 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1033813004061 putative active site [active] 1033813004062 metal binding site [ion binding]; metal-binding site 1033813004063 hypothetical protein; Provisional; Region: PRK11111 1033813004064 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1033813004065 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1033813004066 peptide binding site [polypeptide binding]; other site 1033813004067 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1033813004068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813004069 dimer interface [polypeptide binding]; other site 1033813004070 conserved gate region; other site 1033813004071 putative PBP binding loops; other site 1033813004072 ABC-ATPase subunit interface; other site 1033813004073 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1033813004074 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1033813004075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813004076 dimer interface [polypeptide binding]; other site 1033813004077 conserved gate region; other site 1033813004078 putative PBP binding loops; other site 1033813004079 ABC-ATPase subunit interface; other site 1033813004080 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1033813004081 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813004082 Walker A/P-loop; other site 1033813004083 ATP binding site [chemical binding]; other site 1033813004084 Q-loop/lid; other site 1033813004085 ABC transporter signature motif; other site 1033813004086 Walker B; other site 1033813004087 D-loop; other site 1033813004088 H-loop/switch region; other site 1033813004089 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1033813004090 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1033813004091 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813004092 Walker A/P-loop; other site 1033813004093 ATP binding site [chemical binding]; other site 1033813004094 Q-loop/lid; other site 1033813004095 ABC transporter signature motif; other site 1033813004096 Walker B; other site 1033813004097 D-loop; other site 1033813004098 H-loop/switch region; other site 1033813004099 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1033813004100 dsDNA-mimic protein; Reviewed; Region: PRK05094 1033813004101 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1033813004102 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1033813004103 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1033813004104 putative active site [active] 1033813004105 catalytic site [active] 1033813004106 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1033813004107 putative active site [active] 1033813004108 catalytic site [active] 1033813004109 voltage-gated potassium channel; Provisional; Region: PRK10537 1033813004110 Ion channel; Region: Ion_trans_2; pfam07885 1033813004111 TrkA-N domain; Region: TrkA_N; pfam02254 1033813004112 YciI-like protein; Reviewed; Region: PRK11370 1033813004113 transport protein TonB; Provisional; Region: PRK10819 1033813004114 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1033813004115 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1033813004116 intracellular septation protein A; Reviewed; Region: PRK00259 1033813004117 hypothetical protein; Provisional; Region: PRK02868 1033813004118 outer membrane protein W; Provisional; Region: PRK10959 1033813004119 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1033813004120 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1033813004121 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1033813004122 dimer interface [polypeptide binding]; other site 1033813004123 active site 1033813004124 Int/Topo IB signature motif; other site 1033813004125 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1033813004126 ATP-grasp domain; Region: ATP-grasp; pfam02222 1033813004127 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1033813004128 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1033813004129 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1033813004130 putative active site [active] 1033813004131 putative metal binding site [ion binding]; other site 1033813004132 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1033813004133 substrate binding site [chemical binding]; other site 1033813004134 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1033813004135 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1033813004136 active site 1033813004137 HIGH motif; other site 1033813004138 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1033813004139 KMSKS motif; other site 1033813004140 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1033813004141 tRNA binding surface [nucleotide binding]; other site 1033813004142 anticodon binding site; other site 1033813004143 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1033813004144 ribosome-associated protein; Provisional; Region: PRK11507 1033813004145 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1033813004146 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1033813004147 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1033813004148 homodimer interface [polypeptide binding]; other site 1033813004149 NADP binding site [chemical binding]; other site 1033813004150 substrate binding site [chemical binding]; other site 1033813004151 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033813004152 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1033813004153 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1033813004154 Ash protein family; Region: Phage_ASH; pfam10554 1033813004155 OmpW family; Region: OmpW; cl17427 1033813004156 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1033813004157 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1033813004158 substrate binding site [chemical binding]; other site 1033813004159 active site 1033813004160 catalytic residues [active] 1033813004161 heterodimer interface [polypeptide binding]; other site 1033813004162 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1033813004163 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1033813004164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813004165 catalytic residue [active] 1033813004166 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1033813004167 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1033813004168 active site 1033813004169 ribulose/triose binding site [chemical binding]; other site 1033813004170 phosphate binding site [ion binding]; other site 1033813004171 substrate (anthranilate) binding pocket [chemical binding]; other site 1033813004172 product (indole) binding pocket [chemical binding]; other site 1033813004173 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1033813004174 active site 1033813004175 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1033813004176 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1033813004177 glutamine binding [chemical binding]; other site 1033813004178 catalytic triad [active] 1033813004179 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1033813004180 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1033813004181 anthranilate synthase component I; Provisional; Region: PRK13564 1033813004182 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1033813004183 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1033813004184 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1033813004185 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1033813004186 active site 1033813004187 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1033813004188 hypothetical protein; Provisional; Region: PRK11630 1033813004189 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1033813004190 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1033813004191 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033813004192 RNA binding surface [nucleotide binding]; other site 1033813004193 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1033813004194 probable active site [active] 1033813004195 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1033813004196 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1033813004197 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1033813004198 homodimer interface [polypeptide binding]; other site 1033813004199 Walker A motif; other site 1033813004200 ATP binding site [chemical binding]; other site 1033813004201 hydroxycobalamin binding site [chemical binding]; other site 1033813004202 Walker B motif; other site 1033813004203 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1033813004204 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1033813004205 NADP binding site [chemical binding]; other site 1033813004206 homodimer interface [polypeptide binding]; other site 1033813004207 active site 1033813004208 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1033813004209 putative inner membrane peptidase; Provisional; Region: PRK11778 1033813004210 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1033813004211 tandem repeat interface [polypeptide binding]; other site 1033813004212 oligomer interface [polypeptide binding]; other site 1033813004213 active site residues [active] 1033813004214 hypothetical protein; Provisional; Region: PRK11037 1033813004215 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1033813004216 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1033813004217 active site 1033813004218 interdomain interaction site; other site 1033813004219 putative metal-binding site [ion binding]; other site 1033813004220 nucleotide binding site [chemical binding]; other site 1033813004221 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1033813004222 domain I; other site 1033813004223 DNA binding groove [nucleotide binding] 1033813004224 phosphate binding site [ion binding]; other site 1033813004225 domain II; other site 1033813004226 domain III; other site 1033813004227 nucleotide binding site [chemical binding]; other site 1033813004228 catalytic site [active] 1033813004229 domain IV; other site 1033813004230 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1033813004231 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1033813004232 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1033813004233 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1033813004234 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1033813004235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813004236 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1033813004237 substrate binding site [chemical binding]; other site 1033813004238 putative dimerization interface [polypeptide binding]; other site 1033813004239 aconitate hydratase; Validated; Region: PRK09277 1033813004240 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1033813004241 substrate binding site [chemical binding]; other site 1033813004242 ligand binding site [chemical binding]; other site 1033813004243 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1033813004244 substrate binding site [chemical binding]; other site 1033813004245 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1033813004246 dimerization interface [polypeptide binding]; other site 1033813004247 active site 1033813004248 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1033813004249 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1033813004250 active site 1033813004251 Predicted membrane protein [Function unknown]; Region: COG3771 1033813004252 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1033813004253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1033813004254 TPR motif; other site 1033813004255 binding surface 1033813004256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1033813004257 binding surface 1033813004258 TPR motif; other site 1033813004259 translation initiation factor Sui1; Validated; Region: PRK06824 1033813004260 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1033813004261 putative rRNA binding site [nucleotide binding]; other site 1033813004262 lipoprotein; Provisional; Region: PRK10540 1033813004263 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1033813004264 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1033813004265 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813004266 hypothetical protein; Provisional; Region: PRK13658 1033813004267 RNase II stability modulator; Provisional; Region: PRK10060 1033813004268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813004269 putative active site [active] 1033813004270 heme pocket [chemical binding]; other site 1033813004271 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813004272 metal binding site [ion binding]; metal-binding site 1033813004273 active site 1033813004274 I-site; other site 1033813004275 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813004276 exoribonuclease II; Provisional; Region: PRK05054 1033813004277 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1033813004278 RNB domain; Region: RNB; pfam00773 1033813004279 S1 RNA binding domain; Region: S1; pfam00575 1033813004280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 1033813004281 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1033813004282 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1033813004283 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1033813004284 NAD binding site [chemical binding]; other site 1033813004285 homotetramer interface [polypeptide binding]; other site 1033813004286 homodimer interface [polypeptide binding]; other site 1033813004287 substrate binding site [chemical binding]; other site 1033813004288 active site 1033813004289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1033813004290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813004291 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1033813004292 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813004293 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813004294 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1033813004295 Protein export membrane protein; Region: SecD_SecF; cl14618 1033813004296 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1033813004297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813004298 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1033813004299 putative substrate translocation pore; other site 1033813004300 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1033813004301 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813004302 Walker A/P-loop; other site 1033813004303 ATP binding site [chemical binding]; other site 1033813004304 Q-loop/lid; other site 1033813004305 ABC transporter signature motif; other site 1033813004306 Walker B; other site 1033813004307 D-loop; other site 1033813004308 H-loop/switch region; other site 1033813004309 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1033813004310 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813004311 Walker A/P-loop; other site 1033813004312 ATP binding site [chemical binding]; other site 1033813004313 Q-loop/lid; other site 1033813004314 ABC transporter signature motif; other site 1033813004315 Walker B; other site 1033813004316 D-loop; other site 1033813004317 H-loop/switch region; other site 1033813004318 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1033813004319 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1033813004320 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1033813004321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813004322 dimer interface [polypeptide binding]; other site 1033813004323 conserved gate region; other site 1033813004324 putative PBP binding loops; other site 1033813004325 ABC-ATPase subunit interface; other site 1033813004326 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1033813004327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813004328 dimer interface [polypeptide binding]; other site 1033813004329 conserved gate region; other site 1033813004330 putative PBP binding loops; other site 1033813004331 ABC-ATPase subunit interface; other site 1033813004332 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1033813004333 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1033813004334 peptide binding site [polypeptide binding]; other site 1033813004335 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1033813004336 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1033813004337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813004338 Walker A motif; other site 1033813004339 ATP binding site [chemical binding]; other site 1033813004340 Walker B motif; other site 1033813004341 arginine finger; other site 1033813004342 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1033813004343 phage shock protein PspA; Provisional; Region: PRK10698 1033813004344 phage shock protein B; Provisional; Region: pspB; PRK09458 1033813004345 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1033813004346 phage shock protein C; Region: phageshock_pspC; TIGR02978 1033813004347 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1033813004348 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1033813004349 active site residue [active] 1033813004350 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1033813004351 sucrose phosphorylase; Provisional; Region: PRK13840 1033813004352 active site 1033813004353 homodimer interface [polypeptide binding]; other site 1033813004354 catalytic site [active] 1033813004355 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1033813004356 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1033813004357 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1033813004358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813004359 dimer interface [polypeptide binding]; other site 1033813004360 conserved gate region; other site 1033813004361 putative PBP binding loops; other site 1033813004362 ABC-ATPase subunit interface; other site 1033813004363 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1033813004364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813004365 dimer interface [polypeptide binding]; other site 1033813004366 conserved gate region; other site 1033813004367 putative PBP binding loops; other site 1033813004368 ABC-ATPase subunit interface; other site 1033813004369 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1033813004370 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1033813004371 putative NAD(P) binding site [chemical binding]; other site 1033813004372 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1033813004373 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1033813004374 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1033813004375 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1033813004376 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1033813004377 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1033813004378 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1033813004379 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1033813004380 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1033813004381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813004382 motif II; other site 1033813004383 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1033813004384 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1033813004385 Walker A/P-loop; other site 1033813004386 ATP binding site [chemical binding]; other site 1033813004387 Q-loop/lid; other site 1033813004388 ABC transporter signature motif; other site 1033813004389 Walker B; other site 1033813004390 D-loop; other site 1033813004391 H-loop/switch region; other site 1033813004392 TOBE domain; Region: TOBE_2; pfam08402 1033813004393 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 1033813004394 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1033813004395 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813004396 DNA binding site [nucleotide binding] 1033813004397 domain linker motif; other site 1033813004398 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1033813004399 putative dimerization interface [polypeptide binding]; other site 1033813004400 putative ligand binding site [chemical binding]; other site 1033813004401 Predicted ATPase [General function prediction only]; Region: COG3106 1033813004402 hypothetical protein; Provisional; Region: PRK05415 1033813004403 TIGR01620 family protein; Region: hyp_HI0043 1033813004404 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1033813004405 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1033813004406 putative aromatic amino acid binding site; other site 1033813004407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813004408 Walker A motif; other site 1033813004409 ATP binding site [chemical binding]; other site 1033813004410 Walker B motif; other site 1033813004411 arginine finger; other site 1033813004412 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1033813004413 dimer interface [polypeptide binding]; other site 1033813004414 catalytic triad [active] 1033813004415 peroxidatic and resolving cysteines [active] 1033813004416 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1033813004417 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1033813004418 active site 1033813004419 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1033813004420 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1033813004421 putative active site [active] 1033813004422 Zn binding site [ion binding]; other site 1033813004423 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 1033813004424 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1033813004425 putative NAD(P) binding site [chemical binding]; other site 1033813004426 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1033813004427 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1033813004428 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033813004429 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813004430 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1033813004431 putative effector binding pocket; other site 1033813004432 putative dimerization interface [polypeptide binding]; other site 1033813004433 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1033813004434 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1033813004435 peptide binding site [polypeptide binding]; other site 1033813004436 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1033813004437 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1033813004438 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1033813004439 universal stress protein UspE; Provisional; Region: PRK11175 1033813004440 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1033813004441 Ligand Binding Site [chemical binding]; other site 1033813004442 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1033813004443 Ligand Binding Site [chemical binding]; other site 1033813004444 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1033813004445 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1033813004446 ligand binding site [chemical binding]; other site 1033813004447 flexible hinge region; other site 1033813004448 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1033813004449 putative switch regulator; other site 1033813004450 non-specific DNA interactions [nucleotide binding]; other site 1033813004451 DNA binding site [nucleotide binding] 1033813004452 sequence specific DNA binding site [nucleotide binding]; other site 1033813004453 putative cAMP binding site [chemical binding]; other site 1033813004454 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1033813004455 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1033813004456 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1033813004457 DNA binding site [nucleotide binding] 1033813004458 active site 1033813004459 AbgT putative transporter family; Region: ABG_transport; cl17431 1033813004460 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1033813004461 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1033813004462 Helix-turn-helix domain; Region: HTH_18; pfam12833 1033813004463 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1033813004464 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813004465 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813004466 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1033813004467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813004468 putative substrate translocation pore; other site 1033813004469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813004470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1033813004471 Smr domain; Region: Smr; pfam01713 1033813004472 PAS domain S-box; Region: sensory_box; TIGR00229 1033813004473 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813004474 putative active site [active] 1033813004475 heme pocket [chemical binding]; other site 1033813004476 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1033813004477 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813004478 metal binding site [ion binding]; metal-binding site 1033813004479 active site 1033813004480 I-site; other site 1033813004481 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1033813004482 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1033813004483 Cl binding site [ion binding]; other site 1033813004484 oligomer interface [polypeptide binding]; other site 1033813004485 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1033813004486 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1033813004487 ATP binding site [chemical binding]; other site 1033813004488 Mg++ binding site [ion binding]; other site 1033813004489 motif III; other site 1033813004490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813004491 nucleotide binding region [chemical binding]; other site 1033813004492 ATP-binding site [chemical binding]; other site 1033813004493 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1033813004494 putative RNA binding site [nucleotide binding]; other site 1033813004495 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1033813004496 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1033813004497 Ligand Binding Site [chemical binding]; other site 1033813004498 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033813004499 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1033813004500 Ligand Binding Site [chemical binding]; other site 1033813004501 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1033813004502 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1033813004503 trimer interface [polypeptide binding]; other site 1033813004504 eyelet of channel; other site 1033813004505 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1033813004506 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1033813004507 dimer interface [polypeptide binding]; other site 1033813004508 PYR/PP interface [polypeptide binding]; other site 1033813004509 TPP binding site [chemical binding]; other site 1033813004510 substrate binding site [chemical binding]; other site 1033813004511 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1033813004512 Domain of unknown function; Region: EKR; smart00890 1033813004513 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1033813004514 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1033813004515 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1033813004516 TPP-binding site [chemical binding]; other site 1033813004517 dimer interface [polypeptide binding]; other site 1033813004518 heat-inducible protein; Provisional; Region: PRK10449 1033813004519 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1033813004520 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1033813004521 putative ligand binding site [chemical binding]; other site 1033813004522 putative NAD binding site [chemical binding]; other site 1033813004523 catalytic site [active] 1033813004524 hypothetical protein; Provisional; Region: PRK10695 1033813004525 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1033813004526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1033813004527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813004528 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1033813004529 potential frameshift: common BLAST hit: gi|110641590|ref|YP_669320.1| autotransporter/adhesin 1033813004530 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1033813004531 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033813004532 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033813004533 active site 1033813004534 catalytic tetrad [active] 1033813004535 azoreductase; Reviewed; Region: PRK00170 1033813004536 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1033813004537 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1033813004538 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033813004539 ATP binding site [chemical binding]; other site 1033813004540 putative Mg++ binding site [ion binding]; other site 1033813004541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813004542 nucleotide binding region [chemical binding]; other site 1033813004543 ATP-binding site [chemical binding]; other site 1033813004544 Helicase associated domain (HA2); Region: HA2; pfam04408 1033813004545 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1033813004546 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1033813004547 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1033813004548 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1033813004549 putative active site [active] 1033813004550 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1033813004551 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1033813004552 NAD binding site [chemical binding]; other site 1033813004553 catalytic residues [active] 1033813004554 substrate binding site [chemical binding]; other site 1033813004555 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1033813004556 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1033813004557 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1033813004558 cytochrome b561; Provisional; Region: PRK11513 1033813004559 hypothetical protein; Provisional; Region: PRK10040 1033813004560 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1033813004561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813004562 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1033813004563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1033813004564 dimerization interface [polypeptide binding]; other site 1033813004565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1033813004566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1033813004567 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1033813004568 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1033813004569 hypothetical protein; Provisional; Region: PRK11415 1033813004570 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1033813004571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813004572 Coenzyme A binding pocket [chemical binding]; other site 1033813004573 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1033813004574 putative trimer interface [polypeptide binding]; other site 1033813004575 putative CoA binding site [chemical binding]; other site 1033813004576 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1033813004577 putative trimer interface [polypeptide binding]; other site 1033813004578 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1033813004579 putative CoA binding site [chemical binding]; other site 1033813004580 putative trimer interface [polypeptide binding]; other site 1033813004581 putative CoA binding site [chemical binding]; other site 1033813004582 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1033813004583 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1033813004584 gating phenylalanine in ion channel; other site 1033813004585 tellurite resistance protein TehB; Provisional; Region: PRK11207 1033813004586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813004587 S-adenosylmethionine binding site [chemical binding]; other site 1033813004588 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1033813004589 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1033813004590 benzoate transporter; Region: benE; TIGR00843 1033813004591 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1033813004592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813004593 non-specific DNA binding site [nucleotide binding]; other site 1033813004594 salt bridge; other site 1033813004595 sequence-specific DNA binding site [nucleotide binding]; other site 1033813004596 Cupin domain; Region: Cupin_2; pfam07883 1033813004597 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1033813004598 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1033813004599 Peptidase family U32; Region: Peptidase_U32; pfam01136 1033813004600 Collagenase; Region: DUF3656; pfam12392 1033813004601 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1033813004602 Helix-turn-helix; Region: HTH_3; pfam01381 1033813004603 sequence-specific DNA binding site [nucleotide binding]; other site 1033813004604 salt bridge; other site 1033813004605 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1033813004606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813004607 DNA-binding site [nucleotide binding]; DNA binding site 1033813004608 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1033813004609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813004610 homodimer interface [polypeptide binding]; other site 1033813004611 catalytic residue [active] 1033813004612 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1033813004613 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1033813004614 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1033813004615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813004616 Walker A/P-loop; other site 1033813004617 ATP binding site [chemical binding]; other site 1033813004618 Q-loop/lid; other site 1033813004619 ABC transporter signature motif; other site 1033813004620 Walker B; other site 1033813004621 D-loop; other site 1033813004622 H-loop/switch region; other site 1033813004623 TOBE domain; Region: TOBE_2; pfam08402 1033813004624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813004625 dimer interface [polypeptide binding]; other site 1033813004626 conserved gate region; other site 1033813004627 putative PBP binding loops; other site 1033813004628 ABC-ATPase subunit interface; other site 1033813004629 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1033813004630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813004631 ABC-ATPase subunit interface; other site 1033813004632 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1033813004633 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1033813004634 tetrameric interface [polypeptide binding]; other site 1033813004635 NAD binding site [chemical binding]; other site 1033813004636 catalytic residues [active] 1033813004637 substrate binding site [chemical binding]; other site 1033813004638 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1033813004639 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1033813004640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1033813004641 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1033813004642 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1033813004643 Coenzyme A binding pocket [chemical binding]; other site 1033813004644 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1033813004645 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1033813004646 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813004647 N-terminal plug; other site 1033813004648 ligand-binding site [chemical binding]; other site 1033813004649 PQQ-like domain; Region: PQQ_2; pfam13360 1033813004650 L-asparagine permease; Provisional; Region: PRK15049 1033813004651 putative oxidoreductase; Provisional; Region: PRK09939 1033813004652 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1033813004653 putative molybdopterin cofactor binding site [chemical binding]; other site 1033813004654 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1033813004655 putative molybdopterin cofactor binding site; other site 1033813004656 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 1033813004657 mannosyl binding site [chemical binding]; other site 1033813004658 Fimbrial protein; Region: Fimbrial; pfam00419 1033813004659 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1033813004660 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1033813004661 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1033813004662 PapC N-terminal domain; Region: PapC_N; pfam13954 1033813004663 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1033813004664 PapC C-terminal domain; Region: PapC_C; pfam13953 1033813004665 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1033813004666 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1033813004667 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1033813004668 Fimbrial protein; Region: Fimbrial; cl01416 1033813004669 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1033813004670 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1033813004671 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1033813004672 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1033813004673 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1033813004674 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813004675 non-specific DNA binding site [nucleotide binding]; other site 1033813004676 salt bridge; other site 1033813004677 sequence-specific DNA binding site [nucleotide binding]; other site 1033813004678 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1033813004679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813004680 S-adenosylmethionine binding site [chemical binding]; other site 1033813004681 Predicted membrane protein [Function unknown]; Region: COG3781 1033813004682 altronate oxidoreductase; Provisional; Region: PRK03643 1033813004683 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1033813004684 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1033813004685 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1033813004686 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813004687 metal binding site [ion binding]; metal-binding site 1033813004688 active site 1033813004689 I-site; other site 1033813004690 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1033813004691 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1033813004692 glutaminase; Provisional; Region: PRK00971 1033813004693 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1033813004694 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1033813004695 NAD(P) binding site [chemical binding]; other site 1033813004696 catalytic residues [active] 1033813004697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033813004698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813004699 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1033813004700 putative dimerization interface [polypeptide binding]; other site 1033813004701 putative arabinose transporter; Provisional; Region: PRK03545 1033813004702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813004703 putative substrate translocation pore; other site 1033813004704 inner membrane protein; Provisional; Region: PRK10995 1033813004705 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1033813004706 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1033813004707 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1033813004708 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813004709 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813004710 hypothetical protein; Provisional; Region: PRK10106 1033813004711 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1033813004712 EamA-like transporter family; Region: EamA; pfam00892 1033813004713 EamA-like transporter family; Region: EamA; pfam00892 1033813004714 putative transporter; Provisional; Region: PRK10054 1033813004715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813004716 putative substrate translocation pore; other site 1033813004717 diguanylate cyclase; Provisional; Region: PRK09894 1033813004718 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1033813004719 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813004720 metal binding site [ion binding]; metal-binding site 1033813004721 active site 1033813004722 I-site; other site 1033813004723 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1033813004724 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1033813004725 active site 1033813004726 Zn binding site [ion binding]; other site 1033813004727 malonic semialdehyde reductase; Provisional; Region: PRK10538 1033813004728 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1033813004729 putative NAD(P) binding site [chemical binding]; other site 1033813004730 homodimer interface [polypeptide binding]; other site 1033813004731 homotetramer interface [polypeptide binding]; other site 1033813004732 active site 1033813004733 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1033813004734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813004735 DNA-binding site [nucleotide binding]; DNA binding site 1033813004736 FCD domain; Region: FCD; pfam07729 1033813004737 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 1033813004738 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1033813004739 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1033813004740 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1033813004741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813004742 metabolite-proton symporter; Region: 2A0106; TIGR00883 1033813004743 putative substrate translocation pore; other site 1033813004744 putative oxidoreductase; Provisional; Region: PRK10083 1033813004745 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1033813004746 putative NAD(P) binding site [chemical binding]; other site 1033813004747 catalytic Zn binding site [ion binding]; other site 1033813004748 structural Zn binding site [ion binding]; other site 1033813004749 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1033813004750 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1033813004751 putative active site pocket [active] 1033813004752 putative metal binding site [ion binding]; other site 1033813004753 hypothetical protein; Provisional; Region: PRK02237 1033813004754 hypothetical protein; Provisional; Region: PRK13659 1033813004755 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1033813004756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813004757 Coenzyme A binding pocket [chemical binding]; other site 1033813004758 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1033813004759 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1033813004760 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1033813004761 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1033813004762 putative [Fe4-S4] binding site [ion binding]; other site 1033813004763 putative molybdopterin cofactor binding site [chemical binding]; other site 1033813004764 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1033813004765 putative molybdopterin cofactor binding site; other site 1033813004766 potential frameshift: common BLAST hit: gi|117623774|ref|YP_852687.1| dimethyl sulfoxide reductase subunit YnfF 1033813004767 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813004768 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813004769 potential frameshift: common BLAST hit: gi|378712975|ref|YP_005277868.1| dimethylsulfoxide reductase subunit B 1033813004770 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1033813004771 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1033813004772 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1033813004773 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1033813004774 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1033813004775 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1033813004776 Cl- selectivity filter; other site 1033813004777 Cl- binding residues [ion binding]; other site 1033813004778 pore gating glutamate residue; other site 1033813004779 dimer interface [polypeptide binding]; other site 1033813004780 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1033813004781 AAA domain; Region: AAA_26; pfam13500 1033813004782 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1033813004783 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1033813004784 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033813004785 nucleotide binding site [chemical binding]; other site 1033813004786 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1033813004787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813004788 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1033813004789 dimerization interface [polypeptide binding]; other site 1033813004790 substrate binding pocket [chemical binding]; other site 1033813004791 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1033813004792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813004793 putative substrate translocation pore; other site 1033813004794 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1033813004795 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1033813004796 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1033813004797 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1033813004798 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1033813004799 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1033813004800 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1033813004801 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1033813004802 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1033813004803 ligand binding site [chemical binding]; other site 1033813004804 homodimer interface [polypeptide binding]; other site 1033813004805 NAD(P) binding site [chemical binding]; other site 1033813004806 trimer interface B [polypeptide binding]; other site 1033813004807 trimer interface A [polypeptide binding]; other site 1033813004808 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1033813004809 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1033813004810 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1033813004811 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1033813004812 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1033813004813 Spore germination protein; Region: Spore_permease; cl17796 1033813004814 dihydromonapterin reductase; Provisional; Region: PRK06483 1033813004815 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 1033813004816 NADP binding site [chemical binding]; other site 1033813004817 substrate binding pocket [chemical binding]; other site 1033813004818 active site 1033813004819 GlpM protein; Region: GlpM; pfam06942 1033813004820 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1033813004821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813004822 active site 1033813004823 phosphorylation site [posttranslational modification] 1033813004824 intermolecular recognition site; other site 1033813004825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813004826 DNA binding site [nucleotide binding] 1033813004827 sensor protein RstB; Provisional; Region: PRK10604 1033813004828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033813004829 dimerization interface [polypeptide binding]; other site 1033813004830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813004831 dimer interface [polypeptide binding]; other site 1033813004832 phosphorylation site [posttranslational modification] 1033813004833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813004834 ATP binding site [chemical binding]; other site 1033813004835 Mg2+ binding site [ion binding]; other site 1033813004836 G-X-G motif; other site 1033813004837 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1033813004838 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1033813004839 Class II fumarases; Region: Fumarase_classII; cd01362 1033813004840 active site 1033813004841 tetramer interface [polypeptide binding]; other site 1033813004842 fumarate hydratase; Provisional; Region: PRK15389 1033813004843 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1033813004844 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1033813004845 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1033813004846 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1033813004847 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1033813004848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1033813004849 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1033813004850 putative outer membrane porin protein; Provisional; Region: PRK11379 1033813004851 putative outer membrane porin protein; Provisional; Region: PRK11379 1033813004852 potential frameshift: common BLAST hit: gi|218689562|ref|YP_002397774.1| glucuronide transporter 1033813004853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813004854 putative substrate translocation pore; other site 1033813004855 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1033813004856 beta-D-glucuronidase; Provisional; Region: PRK10150 1033813004857 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1033813004858 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1033813004859 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1033813004860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1033813004861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813004862 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 1033813004863 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 1033813004864 NAD binding site [chemical binding]; other site 1033813004865 substrate binding site [chemical binding]; other site 1033813004866 homotetramer interface [polypeptide binding]; other site 1033813004867 homodimer interface [polypeptide binding]; other site 1033813004868 active site 1033813004869 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1033813004870 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813004871 DNA binding site [nucleotide binding] 1033813004872 domain linker motif; other site 1033813004873 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1033813004874 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1033813004875 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1033813004876 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1033813004877 active site turn [active] 1033813004878 phosphorylation site [posttranslational modification] 1033813004879 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1033813004880 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1033813004881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813004882 homodimer interface [polypeptide binding]; other site 1033813004883 catalytic residue [active] 1033813004884 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1033813004885 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1033813004886 active site 1033813004887 purine riboside binding site [chemical binding]; other site 1033813004888 putative oxidoreductase; Provisional; Region: PRK11579 1033813004889 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1033813004890 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1033813004891 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1033813004892 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1033813004893 electron transport complex protein RsxA; Provisional; Region: PRK05151 1033813004894 electron transport complex protein RnfB; Provisional; Region: PRK05113 1033813004895 Putative Fe-S cluster; Region: FeS; pfam04060 1033813004896 4Fe-4S binding domain; Region: Fer4; pfam00037 1033813004897 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1033813004898 SLBB domain; Region: SLBB; pfam10531 1033813004899 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1033813004900 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1033813004901 electron transport complex protein RnfG; Validated; Region: PRK01908 1033813004902 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1033813004903 endonuclease III; Provisional; Region: PRK10702 1033813004904 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1033813004905 minor groove reading motif; other site 1033813004906 helix-hairpin-helix signature motif; other site 1033813004907 substrate binding pocket [chemical binding]; other site 1033813004908 active site 1033813004909 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1033813004910 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1033813004911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813004912 putative substrate translocation pore; other site 1033813004913 POT family; Region: PTR2; pfam00854 1033813004914 glutathionine S-transferase; Provisional; Region: PRK10542 1033813004915 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1033813004916 C-terminal domain interface [polypeptide binding]; other site 1033813004917 GSH binding site (G-site) [chemical binding]; other site 1033813004918 dimer interface [polypeptide binding]; other site 1033813004919 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1033813004920 N-terminal domain interface [polypeptide binding]; other site 1033813004921 dimer interface [polypeptide binding]; other site 1033813004922 substrate binding pocket (H-site) [chemical binding]; other site 1033813004923 pyridoxamine kinase; Validated; Region: PRK05756 1033813004924 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1033813004925 dimer interface [polypeptide binding]; other site 1033813004926 pyridoxal binding site [chemical binding]; other site 1033813004927 ATP binding site [chemical binding]; other site 1033813004928 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1033813004929 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1033813004930 active site 1033813004931 HIGH motif; other site 1033813004932 dimer interface [polypeptide binding]; other site 1033813004933 KMSKS motif; other site 1033813004934 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033813004935 RNA binding surface [nucleotide binding]; other site 1033813004936 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1033813004937 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1033813004938 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1033813004939 lysozyme inhibitor; Provisional; Region: PRK11372 1033813004940 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1033813004941 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 1033813004942 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1033813004943 transcriptional regulator SlyA; Provisional; Region: PRK03573 1033813004944 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1033813004945 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 1033813004946 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1033813004947 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813004948 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813004949 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1033813004950 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1033813004951 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1033813004952 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1033813004953 E-class dimer interface [polypeptide binding]; other site 1033813004954 P-class dimer interface [polypeptide binding]; other site 1033813004955 active site 1033813004956 Cu2+ binding site [ion binding]; other site 1033813004957 Zn2+ binding site [ion binding]; other site 1033813004958 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033813004959 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033813004960 active site 1033813004961 catalytic tetrad [active] 1033813004962 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1033813004963 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813004964 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1033813004965 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1033813004966 FMN binding site [chemical binding]; other site 1033813004967 active site 1033813004968 substrate binding site [chemical binding]; other site 1033813004969 catalytic residue [active] 1033813004970 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1033813004971 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1033813004972 dimer interface [polypeptide binding]; other site 1033813004973 active site 1033813004974 metal binding site [ion binding]; metal-binding site 1033813004975 glutathione binding site [chemical binding]; other site 1033813004976 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1033813004977 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1033813004978 dimer interface [polypeptide binding]; other site 1033813004979 catalytic site [active] 1033813004980 putative active site [active] 1033813004981 putative substrate binding site [chemical binding]; other site 1033813004982 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1033813004983 putative GSH binding site [chemical binding]; other site 1033813004984 catalytic residues [active] 1033813004985 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1033813004986 NlpC/P60 family; Region: NLPC_P60; pfam00877 1033813004987 superoxide dismutase; Provisional; Region: PRK10543 1033813004988 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1033813004989 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1033813004990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813004991 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1033813004992 putative substrate translocation pore; other site 1033813004993 hypothetical protein; Provisional; Region: PRK14756 1033813004994 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1033813004995 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813004996 DNA binding site [nucleotide binding] 1033813004997 domain linker motif; other site 1033813004998 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1033813004999 dimerization interface [polypeptide binding]; other site 1033813005000 ligand binding site [chemical binding]; other site 1033813005001 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1033813005002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813005003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1033813005004 dimerization interface [polypeptide binding]; other site 1033813005005 putative transporter; Provisional; Region: PRK11043 1033813005006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813005007 putative substrate translocation pore; other site 1033813005008 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1033813005009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1033813005010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813005011 S-adenosylmethionine binding site [chemical binding]; other site 1033813005012 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1033813005013 Lumazine binding domain; Region: Lum_binding; pfam00677 1033813005014 Lumazine binding domain; Region: Lum_binding; pfam00677 1033813005015 multidrug efflux protein; Reviewed; Region: PRK01766 1033813005016 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1033813005017 cation binding site [ion binding]; other site 1033813005018 hypothetical protein; Provisional; Region: PRK09945 1033813005019 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 1033813005020 putative monooxygenase; Provisional; Region: PRK11118 1033813005021 hypothetical protein; Provisional; Region: PRK09897 1033813005022 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1033813005023 hypothetical protein; Provisional; Region: PRK09946 1033813005024 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 1033813005025 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1033813005026 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1033813005027 hypothetical protein; Provisional; Region: PRK09947 1033813005028 putative oxidoreductase; Provisional; Region: PRK09849 1033813005029 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 1033813005030 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1033813005031 hypothetical protein; Provisional; Region: PRK09898 1033813005032 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1033813005033 hypothetical protein; Provisional; Region: PRK10292 1033813005034 pyruvate kinase; Provisional; Region: PRK09206 1033813005035 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1033813005036 domain interfaces; other site 1033813005037 active site 1033813005038 murein lipoprotein; Provisional; Region: PRK15396 1033813005039 L,D-transpeptidase; Provisional; Region: PRK10190 1033813005040 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1033813005041 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1033813005042 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1033813005043 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1033813005044 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1033813005045 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1033813005046 catalytic residue [active] 1033813005047 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1033813005048 FeS assembly protein SufD; Region: sufD; TIGR01981 1033813005049 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1033813005050 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1033813005051 Walker A/P-loop; other site 1033813005052 ATP binding site [chemical binding]; other site 1033813005053 Q-loop/lid; other site 1033813005054 ABC transporter signature motif; other site 1033813005055 Walker B; other site 1033813005056 D-loop; other site 1033813005057 H-loop/switch region; other site 1033813005058 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1033813005059 putative ABC transporter; Region: ycf24; CHL00085 1033813005060 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1033813005061 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1033813005062 CoenzymeA binding site [chemical binding]; other site 1033813005063 subunit interaction site [polypeptide binding]; other site 1033813005064 PHB binding site; other site 1033813005065 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1033813005066 FAD binding domain; Region: FAD_binding_4; pfam01565 1033813005067 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1033813005068 putative inner membrane protein; Provisional; Region: PRK10983 1033813005069 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1033813005070 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 1033813005071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813005072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1033813005073 putative substrate translocation pore; other site 1033813005074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813005075 putative substrate translocation pore; other site 1033813005076 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 1033813005077 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1033813005078 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1033813005079 shikimate binding site; other site 1033813005080 NAD(P) binding site [chemical binding]; other site 1033813005081 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1033813005082 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1033813005083 active site 1033813005084 catalytic residue [active] 1033813005085 dimer interface [polypeptide binding]; other site 1033813005086 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1033813005087 Coenzyme A transferase; Region: CoA_trans; pfam01144 1033813005088 Coenzyme A transferase; Region: CoA_trans; cl17247 1033813005089 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1033813005090 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1033813005091 active site 1033813005092 Cupin domain; Region: Cupin_2; pfam07883 1033813005093 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 1033813005094 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1033813005095 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813005096 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1033813005097 Ligand binding site [chemical binding]; other site 1033813005098 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1033813005099 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 1033813005100 Electron transfer flavoprotein domain; Region: ETF; smart00893 1033813005101 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1033813005102 oxidoreductase; Provisional; Region: PRK10015 1033813005103 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1033813005104 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 1033813005105 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1033813005106 acyl-activating enzyme (AAE) consensus motif; other site 1033813005107 putative AMP binding site [chemical binding]; other site 1033813005108 putative active site [active] 1033813005109 putative CoA binding site [chemical binding]; other site 1033813005110 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1033813005111 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1033813005112 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1033813005113 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1033813005114 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1033813005115 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1033813005116 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1033813005117 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 1033813005118 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1033813005119 hypothetical protein; Validated; Region: PRK00029 1033813005120 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1033813005121 NlpC/P60 family; Region: NLPC_P60; pfam00877 1033813005122 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1033813005123 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1033813005124 Walker A/P-loop; other site 1033813005125 ATP binding site [chemical binding]; other site 1033813005126 Q-loop/lid; other site 1033813005127 ABC transporter signature motif; other site 1033813005128 Walker B; other site 1033813005129 D-loop; other site 1033813005130 H-loop/switch region; other site 1033813005131 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1033813005132 catalytic residues [active] 1033813005133 dimer interface [polypeptide binding]; other site 1033813005134 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1033813005135 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813005136 ABC-ATPase subunit interface; other site 1033813005137 dimer interface [polypeptide binding]; other site 1033813005138 putative PBP binding regions; other site 1033813005139 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1033813005140 IHF dimer interface [polypeptide binding]; other site 1033813005141 IHF - DNA interface [nucleotide binding]; other site 1033813005142 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1033813005143 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1033813005144 putative tRNA-binding site [nucleotide binding]; other site 1033813005145 B3/4 domain; Region: B3_4; pfam03483 1033813005146 tRNA synthetase B5 domain; Region: B5; smart00874 1033813005147 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1033813005148 dimer interface [polypeptide binding]; other site 1033813005149 motif 1; other site 1033813005150 motif 3; other site 1033813005151 motif 2; other site 1033813005152 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1033813005153 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1033813005154 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1033813005155 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1033813005156 dimer interface [polypeptide binding]; other site 1033813005157 motif 1; other site 1033813005158 active site 1033813005159 motif 2; other site 1033813005160 motif 3; other site 1033813005161 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1033813005162 23S rRNA binding site [nucleotide binding]; other site 1033813005163 L21 binding site [polypeptide binding]; other site 1033813005164 L13 binding site [polypeptide binding]; other site 1033813005165 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1033813005166 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1033813005167 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1033813005168 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1033813005169 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1033813005170 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1033813005171 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1033813005172 active site 1033813005173 dimer interface [polypeptide binding]; other site 1033813005174 motif 1; other site 1033813005175 motif 2; other site 1033813005176 motif 3; other site 1033813005177 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1033813005178 anticodon binding site; other site 1033813005179 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1033813005180 6-phosphofructokinase 2; Provisional; Region: PRK10294 1033813005181 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1033813005182 putative substrate binding site [chemical binding]; other site 1033813005183 putative ATP binding site [chemical binding]; other site 1033813005184 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1033813005185 Phosphotransferase enzyme family; Region: APH; pfam01636 1033813005186 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1033813005187 active site 1033813005188 ATP binding site [chemical binding]; other site 1033813005189 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1033813005190 YniB-like protein; Region: YniB; pfam14002 1033813005191 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1033813005192 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1033813005193 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813005194 motif II; other site 1033813005195 inner membrane protein; Provisional; Region: PRK11648 1033813005196 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1033813005197 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1033813005198 cell division modulator; Provisional; Region: PRK10113 1033813005199 hydroperoxidase II; Provisional; Region: katE; PRK11249 1033813005200 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1033813005201 tetramer interface [polypeptide binding]; other site 1033813005202 heme binding pocket [chemical binding]; other site 1033813005203 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1033813005204 domain interactions; other site 1033813005205 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1033813005206 putative active site [active] 1033813005207 YdjC motif; other site 1033813005208 Mg binding site [ion binding]; other site 1033813005209 putative homodimer interface [polypeptide binding]; other site 1033813005210 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1033813005211 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1033813005212 NAD binding site [chemical binding]; other site 1033813005213 sugar binding site [chemical binding]; other site 1033813005214 divalent metal binding site [ion binding]; other site 1033813005215 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1033813005216 dimer interface [polypeptide binding]; other site 1033813005217 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1033813005218 Cupin domain; Region: Cupin_2; pfam07883 1033813005219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813005220 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1033813005221 methionine cluster; other site 1033813005222 active site 1033813005223 phosphorylation site [posttranslational modification] 1033813005224 metal binding site [ion binding]; metal-binding site 1033813005225 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1033813005226 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1033813005227 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1033813005228 active site 1033813005229 P-loop; other site 1033813005230 phosphorylation site [posttranslational modification] 1033813005231 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1033813005232 NAD+ synthetase; Region: nadE; TIGR00552 1033813005233 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1033813005234 homodimer interface [polypeptide binding]; other site 1033813005235 NAD binding pocket [chemical binding]; other site 1033813005236 ATP binding pocket [chemical binding]; other site 1033813005237 Mg binding site [ion binding]; other site 1033813005238 active-site loop [active] 1033813005239 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1033813005240 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1033813005241 active site 1033813005242 GIY-YIG motif/motif A; other site 1033813005243 catalytic site [active] 1033813005244 putative DNA binding site [nucleotide binding]; other site 1033813005245 metal binding site [ion binding]; metal-binding site 1033813005246 hypothetical protein; Provisional; Region: PRK11396 1033813005247 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1033813005248 dimer interface [polypeptide binding]; other site 1033813005249 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1033813005250 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1033813005251 putative active site [active] 1033813005252 Zn binding site [ion binding]; other site 1033813005253 succinylarginine dihydrolase; Provisional; Region: PRK13281 1033813005254 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1033813005255 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1033813005256 NAD(P) binding site [chemical binding]; other site 1033813005257 catalytic residues [active] 1033813005258 arginine succinyltransferase; Provisional; Region: PRK10456 1033813005259 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1033813005260 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1033813005261 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1033813005262 inhibitor-cofactor binding pocket; inhibition site 1033813005263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813005264 catalytic residue [active] 1033813005265 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1033813005266 putative catalytic site [active] 1033813005267 putative phosphate binding site [ion binding]; other site 1033813005268 active site 1033813005269 metal binding site A [ion binding]; metal-binding site 1033813005270 DNA binding site [nucleotide binding] 1033813005271 putative AP binding site [nucleotide binding]; other site 1033813005272 putative metal binding site B [ion binding]; other site 1033813005273 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1033813005274 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1033813005275 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1033813005276 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1033813005277 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1033813005278 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1033813005279 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1033813005280 hypothetical protein; Provisional; Region: PRK11622 1033813005281 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 1033813005282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813005283 dimer interface [polypeptide binding]; other site 1033813005284 conserved gate region; other site 1033813005285 putative PBP binding loops; other site 1033813005286 ABC-ATPase subunit interface; other site 1033813005287 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1033813005288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813005289 Walker A/P-loop; other site 1033813005290 ATP binding site [chemical binding]; other site 1033813005291 Q-loop/lid; other site 1033813005292 ABC transporter signature motif; other site 1033813005293 Walker B; other site 1033813005294 D-loop; other site 1033813005295 H-loop/switch region; other site 1033813005296 Rhodanese Homology Domain; Region: RHOD; smart00450 1033813005297 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1033813005298 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1033813005299 active site residue [active] 1033813005300 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1033813005301 active site residue [active] 1033813005302 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1033813005303 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1033813005304 active site 1033813005305 8-oxo-dGMP binding site [chemical binding]; other site 1033813005306 nudix motif; other site 1033813005307 metal binding site [ion binding]; metal-binding site 1033813005308 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1033813005309 glutamate dehydrogenase; Provisional; Region: PRK09414 1033813005310 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1033813005311 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1033813005312 NAD(P) binding site [chemical binding]; other site 1033813005313 DNA topoisomerase III; Provisional; Region: PRK07726 1033813005314 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1033813005315 active site 1033813005316 putative interdomain interaction site [polypeptide binding]; other site 1033813005317 putative metal-binding site [ion binding]; other site 1033813005318 putative nucleotide binding site [chemical binding]; other site 1033813005319 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1033813005320 domain I; other site 1033813005321 DNA binding groove [nucleotide binding] 1033813005322 phosphate binding site [ion binding]; other site 1033813005323 domain II; other site 1033813005324 domain III; other site 1033813005325 nucleotide binding site [chemical binding]; other site 1033813005326 catalytic site [active] 1033813005327 domain IV; other site 1033813005328 selenophosphate synthetase; Provisional; Region: PRK00943 1033813005329 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1033813005330 dimerization interface [polypeptide binding]; other site 1033813005331 putative ATP binding site [chemical binding]; other site 1033813005332 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1033813005333 putative FMN binding site [chemical binding]; other site 1033813005334 protease 4; Provisional; Region: PRK10949 1033813005335 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1033813005336 tandem repeat interface [polypeptide binding]; other site 1033813005337 oligomer interface [polypeptide binding]; other site 1033813005338 active site residues [active] 1033813005339 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1033813005340 tandem repeat interface [polypeptide binding]; other site 1033813005341 oligomer interface [polypeptide binding]; other site 1033813005342 active site residues [active] 1033813005343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 1033813005344 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1033813005345 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1033813005346 homodimer interface [polypeptide binding]; other site 1033813005347 active site 1033813005348 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1033813005349 Isochorismatase family; Region: Isochorismatase; pfam00857 1033813005350 catalytic triad [active] 1033813005351 metal binding site [ion binding]; metal-binding site 1033813005352 conserved cis-peptide bond; other site 1033813005353 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1033813005354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813005355 putative substrate translocation pore; other site 1033813005356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813005357 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1033813005358 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1033813005359 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813005360 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033813005361 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033813005362 active site 1033813005363 catalytic tetrad [active] 1033813005364 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1033813005365 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1033813005366 substrate binding site [chemical binding]; other site 1033813005367 ATP binding site [chemical binding]; other site 1033813005368 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1033813005369 intersubunit interface [polypeptide binding]; other site 1033813005370 active site 1033813005371 zinc binding site [ion binding]; other site 1033813005372 Na+ binding site [ion binding]; other site 1033813005373 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1033813005374 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1033813005375 inhibitor binding site; inhibition site 1033813005376 catalytic Zn binding site [ion binding]; other site 1033813005377 structural Zn binding site [ion binding]; other site 1033813005378 NADP binding site [chemical binding]; other site 1033813005379 tetramer interface [polypeptide binding]; other site 1033813005380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813005381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813005382 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1033813005383 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1033813005384 putative NAD(P) binding site [chemical binding]; other site 1033813005385 catalytic Zn binding site [ion binding]; other site 1033813005386 structural Zn binding site [ion binding]; other site 1033813005387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1033813005388 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1033813005389 SelR domain; Region: SelR; pfam01641 1033813005390 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1033813005391 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1033813005392 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1033813005393 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1033813005394 active site 1033813005395 phosphate binding residues; other site 1033813005396 catalytic residues [active] 1033813005397 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033813005398 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033813005399 active site 1033813005400 catalytic tetrad [active] 1033813005401 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1033813005402 PrkA family serine protein kinase; Provisional; Region: PRK15455 1033813005403 AAA ATPase domain; Region: AAA_16; pfam13191 1033813005404 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1033813005405 hypothetical protein; Provisional; Region: PRK05325 1033813005406 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1033813005407 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813005408 metal binding site [ion binding]; metal-binding site 1033813005409 active site 1033813005410 I-site; other site 1033813005411 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1033813005412 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813005413 metal binding site [ion binding]; metal-binding site 1033813005414 active site 1033813005415 I-site; other site 1033813005416 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1033813005417 putative deacylase active site [active] 1033813005418 Predicted membrane protein [Function unknown]; Region: COG2707 1033813005419 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1033813005420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813005421 cyanate transporter; Region: CynX; TIGR00896 1033813005422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813005423 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1033813005424 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1033813005425 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1033813005426 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1033813005427 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1033813005428 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1033813005429 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1033813005430 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813005431 metal binding site [ion binding]; metal-binding site 1033813005432 active site 1033813005433 I-site; other site 1033813005434 hypothetical protein; Provisional; Region: PRK10457 1033813005435 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1033813005436 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1033813005437 leucine export protein LeuE; Provisional; Region: PRK10958 1033813005438 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1033813005439 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1033813005440 ribonuclease D; Provisional; Region: PRK10829 1033813005441 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1033813005442 catalytic site [active] 1033813005443 putative active site [active] 1033813005444 putative substrate binding site [chemical binding]; other site 1033813005445 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1033813005446 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1033813005447 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1033813005448 acyl-activating enzyme (AAE) consensus motif; other site 1033813005449 putative AMP binding site [chemical binding]; other site 1033813005450 putative active site [active] 1033813005451 putative CoA binding site [chemical binding]; other site 1033813005452 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 1033813005453 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1033813005454 Glycoprotease family; Region: Peptidase_M22; pfam00814 1033813005455 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1033813005456 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1033813005457 DEAD_2; Region: DEAD_2; pfam06733 1033813005458 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1033813005459 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1033813005460 homotrimer interaction site [polypeptide binding]; other site 1033813005461 putative active site [active] 1033813005462 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1033813005463 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1033813005464 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1033813005465 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1033813005466 putative active site [active] 1033813005467 putative CoA binding site [chemical binding]; other site 1033813005468 nudix motif; other site 1033813005469 metal binding site [ion binding]; metal-binding site 1033813005470 L-serine deaminase; Provisional; Region: PRK15023 1033813005471 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1033813005472 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1033813005473 phage resistance protein; Provisional; Region: PRK10551 1033813005474 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1033813005475 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813005476 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1033813005477 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1033813005478 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1033813005479 Transporter associated domain; Region: CorC_HlyC; smart01091 1033813005480 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1033813005481 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1033813005482 active pocket/dimerization site; other site 1033813005483 active site 1033813005484 phosphorylation site [posttranslational modification] 1033813005485 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1033813005486 active site 1033813005487 phosphorylation site [posttranslational modification] 1033813005488 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1033813005489 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1033813005490 Predicted membrane protein [Function unknown]; Region: COG4811 1033813005491 hypothetical protein; Provisional; Region: PRK11469 1033813005492 Domain of unknown function DUF; Region: DUF204; pfam02659 1033813005493 Domain of unknown function DUF; Region: DUF204; pfam02659 1033813005494 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1033813005495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813005496 S-adenosylmethionine binding site [chemical binding]; other site 1033813005497 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1033813005498 DNA-binding site [nucleotide binding]; DNA binding site 1033813005499 RNA-binding motif; other site 1033813005500 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 1033813005501 YebO-like protein; Region: YebO; pfam13974 1033813005502 PhoPQ regulatory protein; Provisional; Region: PRK10299 1033813005503 YobH-like protein; Region: YobH; pfam13996 1033813005504 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1033813005505 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1033813005506 dimerization interface [polypeptide binding]; other site 1033813005507 putative Zn2+ binding site [ion binding]; other site 1033813005508 putative DNA binding site [nucleotide binding]; other site 1033813005509 Bacterial transcriptional regulator; Region: IclR; pfam01614 1033813005510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813005511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1033813005512 putative substrate translocation pore; other site 1033813005513 Predicted integral membrane protein [Function unknown]; Region: COG5521 1033813005514 heat shock protein HtpX; Provisional; Region: PRK05457 1033813005515 carboxy-terminal protease; Provisional; Region: PRK11186 1033813005516 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1033813005517 protein binding site [polypeptide binding]; other site 1033813005518 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1033813005519 Catalytic dyad [active] 1033813005520 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1033813005521 ProP expression regulator; Provisional; Region: PRK04950 1033813005522 ProQ/FINO family; Region: ProQ; pfam04352 1033813005523 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1033813005524 GAF domain; Region: GAF_2; pfam13185 1033813005525 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 1033813005526 Paraquat-inducible protein A; Region: PqiA; pfam04403 1033813005527 Paraquat-inducible protein A; Region: PqiA; pfam04403 1033813005528 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1033813005529 mce related protein; Region: MCE; pfam02470 1033813005530 mce related protein; Region: MCE; pfam02470 1033813005531 mce related protein; Region: MCE; pfam02470 1033813005532 mce related protein; Region: MCE; pfam02470 1033813005533 mce related protein; Region: MCE; pfam02470 1033813005534 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1033813005535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813005536 S-adenosylmethionine binding site [chemical binding]; other site 1033813005537 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1033813005538 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1033813005539 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1033813005540 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1033813005541 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1033813005542 active site 1033813005543 metal binding site [ion binding]; metal-binding site 1033813005544 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1033813005545 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1033813005546 hypothetical protein; Provisional; Region: PRK10301 1033813005547 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1033813005548 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1033813005549 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 1033813005550 exodeoxyribonuclease X; Provisional; Region: PRK07983 1033813005551 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1033813005552 active site 1033813005553 catalytic site [active] 1033813005554 substrate binding site [chemical binding]; other site 1033813005555 protease 2; Provisional; Region: PRK10115 1033813005556 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1033813005557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1033813005558 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1033813005559 putative metal binding site [ion binding]; other site 1033813005560 hypothetical protein; Provisional; Region: PRK13680 1033813005561 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 1033813005562 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1033813005563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1033813005564 ATP-grasp domain; Region: ATP-grasp; pfam02222 1033813005565 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1033813005566 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1033813005567 active site 1033813005568 intersubunit interface [polypeptide binding]; other site 1033813005569 catalytic residue [active] 1033813005570 phosphogluconate dehydratase; Validated; Region: PRK09054 1033813005571 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1033813005572 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1033813005573 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1033813005574 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1033813005575 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1033813005576 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1033813005577 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1033813005578 putative active site [active] 1033813005579 pyruvate kinase; Provisional; Region: PRK05826 1033813005580 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1033813005581 domain interfaces; other site 1033813005582 active site 1033813005583 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1033813005584 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1033813005585 putative acyl-acceptor binding pocket; other site 1033813005586 putative peptidase; Provisional; Region: PRK11649 1033813005587 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1033813005588 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1033813005589 Peptidase family M23; Region: Peptidase_M23; pfam01551 1033813005590 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1033813005591 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813005592 metal binding site [ion binding]; metal-binding site 1033813005593 active site 1033813005594 I-site; other site 1033813005595 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1033813005596 hypothetical protein; Provisional; Region: PRK10062 1033813005597 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1033813005598 EamA-like transporter family; Region: EamA; pfam00892 1033813005599 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1033813005600 additional DNA contacts [nucleotide binding]; other site 1033813005601 mismatch recognition site; other site 1033813005602 active site 1033813005603 zinc binding site [ion binding]; other site 1033813005604 DNA intercalation site [nucleotide binding]; other site 1033813005605 DNA cytosine methylase; Provisional; Region: PRK10458 1033813005606 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1033813005607 cofactor binding site; other site 1033813005608 DNA binding site [nucleotide binding] 1033813005609 substrate interaction site [chemical binding]; other site 1033813005610 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1033813005611 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1033813005612 Zn2+ binding site [ion binding]; other site 1033813005613 Mg2+ binding site [ion binding]; other site 1033813005614 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1033813005615 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1033813005616 eyelet of channel; other site 1033813005617 trimer interface [polypeptide binding]; other site 1033813005618 chaperone protein HchA; Provisional; Region: PRK04155 1033813005619 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 1033813005620 dimer interface [polypeptide binding]; other site 1033813005621 metal binding site [ion binding]; metal-binding site 1033813005622 potential oxyanion hole; other site 1033813005623 potential catalytic triad [active] 1033813005624 conserved cys residue [active] 1033813005625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813005626 dimer interface [polypeptide binding]; other site 1033813005627 phosphorylation site [posttranslational modification] 1033813005628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813005629 ATP binding site [chemical binding]; other site 1033813005630 Mg2+ binding site [ion binding]; other site 1033813005631 G-X-G motif; other site 1033813005632 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 1033813005633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813005634 active site 1033813005635 phosphorylation site [posttranslational modification] 1033813005636 intermolecular recognition site; other site 1033813005637 dimerization interface [polypeptide binding]; other site 1033813005638 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813005639 DNA binding site [nucleotide binding] 1033813005640 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1033813005641 active site 1033813005642 homotetramer interface [polypeptide binding]; other site 1033813005643 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1033813005644 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1033813005645 Moco binding site; other site 1033813005646 metal coordination site [ion binding]; other site 1033813005647 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1033813005648 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1033813005649 metal binding site [ion binding]; metal-binding site 1033813005650 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1033813005651 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1033813005652 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1033813005653 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813005654 ABC-ATPase subunit interface; other site 1033813005655 dimer interface [polypeptide binding]; other site 1033813005656 putative PBP binding regions; other site 1033813005657 Integrase core domain; Region: rve; pfam00665 1033813005658 Integrase core domain; Region: rve_2; pfam13333 1033813005659 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1033813005660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813005661 Walker A motif; other site 1033813005662 ATP binding site [chemical binding]; other site 1033813005663 Walker B motif; other site 1033813005664 arginine finger; other site 1033813005665 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1033813005666 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1033813005667 RuvA N terminal domain; Region: RuvA_N; pfam01330 1033813005668 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1033813005669 hypothetical protein; Provisional; Region: PRK11470 1033813005670 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1033813005671 active site 1033813005672 putative DNA-binding cleft [nucleotide binding]; other site 1033813005673 dimer interface [polypeptide binding]; other site 1033813005674 hypothetical protein; Validated; Region: PRK00110 1033813005675 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1033813005676 nudix motif; other site 1033813005677 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1033813005678 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1033813005679 dimer interface [polypeptide binding]; other site 1033813005680 anticodon binding site; other site 1033813005681 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1033813005682 homodimer interface [polypeptide binding]; other site 1033813005683 motif 1; other site 1033813005684 active site 1033813005685 motif 2; other site 1033813005686 GAD domain; Region: GAD; pfam02938 1033813005687 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1033813005688 motif 3; other site 1033813005689 Isochorismatase family; Region: Isochorismatase; pfam00857 1033813005690 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1033813005691 catalytic triad [active] 1033813005692 conserved cis-peptide bond; other site 1033813005693 hypothetical protein; Provisional; Region: PRK10302 1033813005694 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1033813005695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813005696 S-adenosylmethionine binding site [chemical binding]; other site 1033813005697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813005698 S-adenosylmethionine binding site [chemical binding]; other site 1033813005699 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1033813005700 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1033813005701 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1033813005702 molybdopterin cofactor binding site [chemical binding]; other site 1033813005703 substrate binding site [chemical binding]; other site 1033813005704 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1033813005705 molybdopterin cofactor binding site; other site 1033813005706 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 1033813005707 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1033813005708 copper homeostasis protein CutC; Provisional; Region: PRK11572 1033813005709 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1033813005710 putative metal binding site [ion binding]; other site 1033813005711 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1033813005712 arginyl-tRNA synthetase; Region: argS; TIGR00456 1033813005713 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1033813005714 active site 1033813005715 HIGH motif; other site 1033813005716 KMSK motif region; other site 1033813005717 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1033813005718 tRNA binding surface [nucleotide binding]; other site 1033813005719 anticodon binding site; other site 1033813005720 Flagellar protein FlhE; Region: FlhE; pfam06366 1033813005721 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1033813005722 FHIPEP family; Region: FHIPEP; pfam00771 1033813005723 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1033813005724 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1033813005725 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1033813005726 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1033813005727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813005728 active site 1033813005729 phosphorylation site [posttranslational modification] 1033813005730 intermolecular recognition site; other site 1033813005731 dimerization interface [polypeptide binding]; other site 1033813005732 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1033813005733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813005734 active site 1033813005735 phosphorylation site [posttranslational modification] 1033813005736 intermolecular recognition site; other site 1033813005737 dimerization interface [polypeptide binding]; other site 1033813005738 CheB methylesterase; Region: CheB_methylest; pfam01339 1033813005739 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1033813005740 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1033813005741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813005742 S-adenosylmethionine binding site [chemical binding]; other site 1033813005743 potential frameshift: common BLAST hit: gi|383177867|ref|YP_005455872.1| methyl-accepting protein IV 1033813005744 methyl-accepting protein IV; Provisional; Region: PRK09793 1033813005745 methyl-accepting protein IV; Provisional; Region: PRK09793 1033813005746 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1033813005747 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1033813005748 dimer interface [polypeptide binding]; other site 1033813005749 ligand binding site [chemical binding]; other site 1033813005750 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033813005751 dimerization interface [polypeptide binding]; other site 1033813005752 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1033813005753 dimer interface [polypeptide binding]; other site 1033813005754 putative CheW interface [polypeptide binding]; other site 1033813005755 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1033813005756 putative CheA interaction surface; other site 1033813005757 chemotaxis protein CheA; Provisional; Region: PRK10547 1033813005758 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1033813005759 putative binding surface; other site 1033813005760 active site 1033813005761 CheY binding; Region: CheY-binding; pfam09078 1033813005762 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1033813005763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813005764 ATP binding site [chemical binding]; other site 1033813005765 Mg2+ binding site [ion binding]; other site 1033813005766 G-X-G motif; other site 1033813005767 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1033813005768 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1033813005769 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1033813005770 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1033813005771 ligand binding site [chemical binding]; other site 1033813005772 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1033813005773 flagellar motor protein MotA; Validated; Region: PRK09110 1033813005774 transcriptional activator FlhC; Provisional; Region: PRK12722 1033813005775 transcriptional activator FlhD; Provisional; Region: PRK02909 1033813005776 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1033813005777 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1033813005778 active site 1033813005779 homotetramer interface [polypeptide binding]; other site 1033813005780 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1033813005781 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1033813005782 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1033813005783 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033813005784 TM-ABC transporter signature motif; other site 1033813005785 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1033813005786 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1033813005787 Walker A/P-loop; other site 1033813005788 ATP binding site [chemical binding]; other site 1033813005789 Q-loop/lid; other site 1033813005790 ABC transporter signature motif; other site 1033813005791 Walker B; other site 1033813005792 D-loop; other site 1033813005793 H-loop/switch region; other site 1033813005794 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1033813005795 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1033813005796 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1033813005797 ligand binding site [chemical binding]; other site 1033813005798 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1033813005799 Ferritin-like domain; Region: Ferritin; pfam00210 1033813005800 ferroxidase diiron center [ion binding]; other site 1033813005801 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1033813005802 YecR-like lipoprotein; Region: YecR; pfam13992 1033813005803 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1033813005804 Ferritin-like domain; Region: Ferritin; pfam00210 1033813005805 ferroxidase diiron center [ion binding]; other site 1033813005806 probable metal-binding protein; Region: matur_matur; TIGR03853 1033813005807 tyrosine transporter TyrP; Provisional; Region: PRK15132 1033813005808 aromatic amino acid transport protein; Region: araaP; TIGR00837 1033813005809 hypothetical protein; Provisional; Region: PRK10396 1033813005810 yecA family protein; Region: ygfB_yecA; TIGR02292 1033813005811 SEC-C motif; Region: SEC-C; pfam02810 1033813005812 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1033813005813 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1033813005814 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1033813005815 Phage tail tube protein FII; Region: Phage_tube; cl01390 1033813005816 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1033813005817 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1033813005818 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1033813005819 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 1033813005820 Baseplate J-like protein; Region: Baseplate_J; cl01294 1033813005821 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1033813005822 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1033813005823 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1033813005824 DNA packaging protein FI; Region: Packaging_FI; pfam14000 1033813005825 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1033813005826 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1033813005827 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1033813005828 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1033813005829 tandem repeat interface [polypeptide binding]; other site 1033813005830 oligomer interface [polypeptide binding]; other site 1033813005831 active site residues [active] 1033813005832 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1033813005833 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1033813005834 gpW; Region: gpW; pfam02831 1033813005835 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 1033813005836 TIGR02594 family protein; Region: TIGR02594 1033813005837 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 1033813005838 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 1033813005839 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1033813005840 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1033813005841 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1033813005842 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1033813005843 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1033813005844 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1033813005845 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1033813005846 GIY-YIG motif/motif A; other site 1033813005847 active site 1033813005848 catalytic site [active] 1033813005849 putative DNA binding site [nucleotide binding]; other site 1033813005850 metal binding site [ion binding]; metal-binding site 1033813005851 UvrB/uvrC motif; Region: UVR; pfam02151 1033813005852 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1033813005853 Helix-hairpin-helix motif; Region: HHH; pfam00633 1033813005854 response regulator; Provisional; Region: PRK09483 1033813005855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813005856 active site 1033813005857 phosphorylation site [posttranslational modification] 1033813005858 intermolecular recognition site; other site 1033813005859 dimerization interface [polypeptide binding]; other site 1033813005860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813005861 DNA binding residues [nucleotide binding] 1033813005862 dimerization interface [polypeptide binding]; other site 1033813005863 hypothetical protein; Provisional; Region: PRK10613 1033813005864 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1033813005865 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1033813005866 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813005867 DNA binding residues [nucleotide binding] 1033813005868 dimerization interface [polypeptide binding]; other site 1033813005869 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1033813005870 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1033813005871 Walker A/P-loop; other site 1033813005872 ATP binding site [chemical binding]; other site 1033813005873 Q-loop/lid; other site 1033813005874 ABC transporter signature motif; other site 1033813005875 Walker B; other site 1033813005876 D-loop; other site 1033813005877 H-loop/switch region; other site 1033813005878 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1033813005879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813005880 dimer interface [polypeptide binding]; other site 1033813005881 conserved gate region; other site 1033813005882 putative PBP binding loops; other site 1033813005883 ABC-ATPase subunit interface; other site 1033813005884 D-cysteine desulfhydrase; Validated; Region: PRK03910 1033813005885 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1033813005886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813005887 catalytic residue [active] 1033813005888 cystine transporter subunit; Provisional; Region: PRK11260 1033813005889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813005890 substrate binding pocket [chemical binding]; other site 1033813005891 membrane-bound complex binding site; other site 1033813005892 hinge residues; other site 1033813005893 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1033813005894 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1033813005895 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1033813005896 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1033813005897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1033813005898 DNA binding residues [nucleotide binding] 1033813005899 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 1033813005900 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1033813005901 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1033813005902 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1033813005903 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1033813005904 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1033813005905 FliG C-terminal domain; Region: FliG_C; pfam01706 1033813005906 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1033813005907 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1033813005908 Flagellar assembly protein FliH; Region: FliH; pfam02108 1033813005909 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1033813005910 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1033813005911 Walker A motif/ATP binding site; other site 1033813005912 Walker B motif; other site 1033813005913 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1033813005914 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1033813005915 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1033813005916 flagellar hook-length control protein; Provisional; Region: PRK10118 1033813005917 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1033813005918 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1033813005919 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1033813005920 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1033813005921 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1033813005922 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1033813005923 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1033813005924 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1033813005925 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1033813005926 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1033813005927 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813005928 DNA binding residues [nucleotide binding] 1033813005929 dimerization interface [polypeptide binding]; other site 1033813005930 hypothetical protein; Provisional; Region: PRK10708 1033813005931 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1033813005932 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1033813005933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813005934 motif II; other site 1033813005935 exonuclease VIII; Reviewed; Region: PRK09709 1033813005936 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1033813005937 active site 1033813005938 substrate binding site [chemical binding]; other site 1033813005939 catalytic site [active] 1033813005940 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 1033813005941 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033813005942 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033813005943 active site 1033813005944 DNA binding site [nucleotide binding] 1033813005945 Int/Topo IB signature motif; other site 1033813005946 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1033813005947 integrase; Provisional; Region: PRK09692 1033813005948 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1033813005949 active site 1033813005950 Int/Topo IB signature motif; other site 1033813005951 salicylate synthase Irp9; Reviewed; Region: PRK06772 1033813005952 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1033813005953 muropeptide transporter; Validated; Region: ampG; cl17669 1033813005954 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1033813005955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813005956 Walker A/P-loop; other site 1033813005957 ATP binding site [chemical binding]; other site 1033813005958 Q-loop/lid; other site 1033813005959 ABC transporter signature motif; other site 1033813005960 Walker B; other site 1033813005961 D-loop; other site 1033813005962 H-loop/switch region; other site 1033813005963 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033813005964 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1033813005965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813005966 Walker A/P-loop; other site 1033813005967 ATP binding site [chemical binding]; other site 1033813005968 Q-loop/lid; other site 1033813005969 ABC transporter signature motif; other site 1033813005970 Walker B; other site 1033813005971 D-loop; other site 1033813005972 H-loop/switch region; other site 1033813005973 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1033813005974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813005975 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1033813005976 Condensation domain; Region: Condensation; pfam00668 1033813005977 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1033813005978 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1033813005979 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1033813005980 acyl-activating enzyme (AAE) consensus motif; other site 1033813005981 AMP binding site [chemical binding]; other site 1033813005982 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1033813005983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813005984 S-adenosylmethionine binding site [chemical binding]; other site 1033813005985 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1033813005986 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1033813005987 Condensation domain; Region: Condensation; pfam00668 1033813005988 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1033813005989 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1033813005990 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1033813005991 potential frameshift: common BLAST hit: gi|384122268|ref|YP_005504888.1| yersiniabactin biosynthetic protein 1033813005992 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1033813005993 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1033813005994 active site 1033813005995 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1033813005996 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1033813005997 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1033813005998 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1033813005999 KR domain; Region: KR; pfam08659 1033813006000 NADP binding site [chemical binding]; other site 1033813006001 active site 1033813006002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1033813006003 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1033813006004 Condensation domain; Region: Condensation; pfam00668 1033813006005 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1033813006006 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1033813006007 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1033813006008 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1033813006009 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1033813006010 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 1033813006011 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1033813006012 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1033813006013 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1033813006014 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1033813006015 acyl-activating enzyme (AAE) consensus motif; other site 1033813006016 active site 1033813006017 AMP binding site [chemical binding]; other site 1033813006018 substrate binding site [chemical binding]; other site 1033813006019 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1033813006020 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813006021 N-terminal plug; other site 1033813006022 ligand-binding site [chemical binding]; other site 1033813006023 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1033813006024 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1033813006025 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1033813006026 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1033813006027 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1033813006028 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1033813006029 shikimate transporter; Provisional; Region: PRK09952 1033813006030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813006031 putative substrate translocation pore; other site 1033813006032 AMP nucleosidase; Provisional; Region: PRK08292 1033813006033 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1033813006034 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1033813006035 hypothetical protein; Provisional; Region: PRK12378 1033813006036 MATE family multidrug exporter; Provisional; Region: PRK10189 1033813006037 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1033813006038 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1033813006039 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813006040 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 1033813006041 putative substrate binding site [chemical binding]; other site 1033813006042 dimerization interface [polypeptide binding]; other site 1033813006043 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1033813006044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813006045 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1033813006046 putative dimerization interface [polypeptide binding]; other site 1033813006047 L,D-transpeptidase; Provisional; Region: PRK10190 1033813006048 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1033813006049 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1033813006050 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1033813006051 putative dimer interface [polypeptide binding]; other site 1033813006052 active site pocket [active] 1033813006053 putative cataytic base [active] 1033813006054 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 1033813006055 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1033813006056 homotrimer interface [polypeptide binding]; other site 1033813006057 Walker A motif; other site 1033813006058 GTP binding site [chemical binding]; other site 1033813006059 Walker B motif; other site 1033813006060 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1033813006061 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813006062 N-terminal plug; other site 1033813006063 ligand-binding site [chemical binding]; other site 1033813006064 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1033813006065 ParB-like nuclease domain; Region: ParBc; cl02129 1033813006066 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1033813006067 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1033813006068 Active Sites [active] 1033813006069 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1033813006070 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1033813006071 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1033813006072 DXD motif; other site 1033813006073 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1033813006074 putative trimer interface [polypeptide binding]; other site 1033813006075 putative CoA binding site [chemical binding]; other site 1033813006076 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1033813006077 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1033813006078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1033813006079 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1033813006080 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1033813006081 active site 1033813006082 substrate binding pocket [chemical binding]; other site 1033813006083 homodimer interaction site [polypeptide binding]; other site 1033813006084 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1033813006085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1033813006086 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1033813006087 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1033813006088 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1033813006089 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 1033813006090 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 1033813006091 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1033813006092 Reverse gyrase [DNA replication, recombination, and repair]; Region: COG1110 1033813006093 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1033813006094 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1033813006095 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1033813006096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1033813006097 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1033813006098 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 1033813006099 Predicted GTPase [General function prediction only]; Region: COG3596 1033813006100 YfjP GTPase; Region: YfjP; cd11383 1033813006101 Switch II region; other site 1033813006102 G3 box; other site 1033813006103 G4 box; other site 1033813006104 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1033813006105 G4 box; other site 1033813006106 G5 box; other site 1033813006107 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1033813006108 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 1033813006109 hypothetical protein; Provisional; Region: PRK09945 1033813006110 transposase/IS protein; Provisional; Region: PRK09183 1033813006111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813006112 Walker A motif; other site 1033813006113 ATP binding site [chemical binding]; other site 1033813006114 Walker B motif; other site 1033813006115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1033813006116 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1033813006117 DNA-binding interface [nucleotide binding]; DNA binding site 1033813006118 Integrase core domain; Region: rve; pfam00665 1033813006119 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1033813006120 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1033813006121 Walker A/P-loop; other site 1033813006122 ATP binding site [chemical binding]; other site 1033813006123 Q-loop/lid; other site 1033813006124 ABC transporter signature motif; other site 1033813006125 Walker B; other site 1033813006126 D-loop; other site 1033813006127 H-loop/switch region; other site 1033813006128 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813006129 dimer interface [polypeptide binding]; other site 1033813006130 putative PBP binding regions; other site 1033813006131 ABC-ATPase subunit interface; other site 1033813006132 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1033813006133 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1033813006134 putative ligand binding residues [chemical binding]; other site 1033813006135 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1033813006136 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813006137 N-terminal plug; other site 1033813006138 ligand-binding site [chemical binding]; other site 1033813006139 YfjP GTPase; Region: YfjP; cd11383 1033813006140 G1 box; other site 1033813006141 GTP/Mg2+ binding site [chemical binding]; other site 1033813006142 Switch I region; other site 1033813006143 G2 box; other site 1033813006144 Switch II region; other site 1033813006145 G3 box; other site 1033813006146 Predicted GTPase [General function prediction only]; Region: COG3596 1033813006147 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1033813006148 G1 box; other site 1033813006149 GTP/Mg2+ binding site [chemical binding]; other site 1033813006150 G2 box; other site 1033813006151 Switch I region; other site 1033813006152 hypothetical protein; Provisional; Region: PRK09866 1033813006153 YjcZ-like protein; Region: YjcZ; pfam13990 1033813006154 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1033813006155 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1033813006156 nucleophile elbow; other site 1033813006157 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1033813006158 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1033813006159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1033813006160 Integrase core domain; Region: rve; pfam00665 1033813006161 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1033813006162 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1033813006163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813006164 Walker A motif; other site 1033813006165 ATP binding site [chemical binding]; other site 1033813006166 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1033813006167 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 1033813006168 Domain of unknown function (DUF932); Region: DUF932; cl12129 1033813006169 Replication regulatory protein RepB; Region: RepB-RCR_reg; cl11673 1033813006170 Predicted GTPase [General function prediction only]; Region: COG3596 1033813006171 YfjP GTPase; Region: YfjP; cd11383 1033813006172 G1 box; other site 1033813006173 GTP/Mg2+ binding site [chemical binding]; other site 1033813006174 Switch I region; other site 1033813006175 G2 box; other site 1033813006176 Switch II region; other site 1033813006177 G3 box; other site 1033813006178 G4 box; other site 1033813006179 G5 box; other site 1033813006180 HTH domain; Region: HTH_11; cl17392 1033813006181 WYL domain; Region: WYL; pfam13280 1033813006182 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 1033813006183 Domain of unknown function (DUF932); Region: DUF932; cl12129 1033813006184 Domain of unknown function (DUF932); Region: DUF932; cl12129 1033813006185 Antirestriction protein; Region: Antirestrict; pfam03230 1033813006186 Domain of unknown function (DUF932); Region: DUF932; cl12129 1033813006187 Domain of unknown function (DUF932); Region: DUF932; cl12129 1033813006188 Domain of unknown function (DUF932); Region: DUF932; cl12129 1033813006189 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1033813006190 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 1033813006191 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1033813006192 substrate binding site; other site 1033813006193 tetramer interface; other site 1033813006194 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 1033813006195 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1033813006196 NADP binding site [chemical binding]; other site 1033813006197 active site 1033813006198 putative substrate binding site [chemical binding]; other site 1033813006199 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1033813006200 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1033813006201 NAD binding site [chemical binding]; other site 1033813006202 substrate binding site [chemical binding]; other site 1033813006203 homodimer interface [polypeptide binding]; other site 1033813006204 active site 1033813006205 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1033813006206 active site 1033813006207 tetramer interface; other site 1033813006208 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 1033813006209 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 1033813006210 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1033813006211 putative ADP-binding pocket [chemical binding]; other site 1033813006212 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1033813006213 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 1033813006214 colanic acid exporter; Provisional; Region: PRK10459 1033813006215 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1033813006216 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1033813006217 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1033813006218 phosphomannomutase CpsG; Provisional; Region: PRK15414 1033813006219 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1033813006220 active site 1033813006221 substrate binding site [chemical binding]; other site 1033813006222 metal binding site [ion binding]; metal-binding site 1033813006223 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1033813006224 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1033813006225 Substrate binding site; other site 1033813006226 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1033813006227 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 1033813006228 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1033813006229 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1033813006230 active site 1033813006231 GDP-Mannose binding site [chemical binding]; other site 1033813006232 dimer interface [polypeptide binding]; other site 1033813006233 modified nudix motif 1033813006234 metal binding site [ion binding]; metal-binding site 1033813006235 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1033813006236 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1033813006237 NADP binding site [chemical binding]; other site 1033813006238 active site 1033813006239 putative substrate binding site [chemical binding]; other site 1033813006240 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1033813006241 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1033813006242 NADP-binding site; other site 1033813006243 homotetramer interface [polypeptide binding]; other site 1033813006244 substrate binding site [chemical binding]; other site 1033813006245 homodimer interface [polypeptide binding]; other site 1033813006246 active site 1033813006247 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1033813006248 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1033813006249 putative trimer interface [polypeptide binding]; other site 1033813006250 putative active site [active] 1033813006251 putative substrate binding site [chemical binding]; other site 1033813006252 putative CoA binding site [chemical binding]; other site 1033813006253 putative glycosyl transferase; Provisional; Region: PRK10063 1033813006254 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1033813006255 metal-binding site 1033813006256 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 1033813006257 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1033813006258 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1033813006259 putative acyl transferase; Provisional; Region: PRK10191 1033813006260 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1033813006261 trimer interface [polypeptide binding]; other site 1033813006262 active site 1033813006263 substrate binding site [chemical binding]; other site 1033813006264 CoA binding site [chemical binding]; other site 1033813006265 putative glycosyl transferase; Provisional; Region: PRK10018 1033813006266 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1033813006267 active site 1033813006268 tyrosine kinase; Provisional; Region: PRK11519 1033813006269 Chain length determinant protein; Region: Wzz; pfam02706 1033813006270 Chain length determinant protein; Region: Wzz; cl15801 1033813006271 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1033813006272 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1033813006273 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1033813006274 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1033813006275 active site 1033813006276 polysaccharide export protein Wza; Provisional; Region: PRK15078 1033813006277 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1033813006278 SLBB domain; Region: SLBB; pfam10531 1033813006279 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1033813006280 Integral membrane protein TerC family; Region: TerC; cl10468 1033813006281 FOG: CBS domain [General function prediction only]; Region: COG0517 1033813006282 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1033813006283 Transporter associated domain; Region: CorC_HlyC; smart01091 1033813006284 putative assembly protein; Provisional; Region: PRK10833 1033813006285 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1033813006286 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1033813006287 trimer interface [polypeptide binding]; other site 1033813006288 active site 1033813006289 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1033813006290 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1033813006291 ATP-binding site [chemical binding]; other site 1033813006292 Sugar specificity; other site 1033813006293 Pyrimidine base specificity; other site 1033813006294 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1033813006295 putative diguanylate cyclase; Provisional; Region: PRK09776 1033813006296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813006297 putative active site [active] 1033813006298 heme pocket [chemical binding]; other site 1033813006299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813006300 putative active site [active] 1033813006301 heme pocket [chemical binding]; other site 1033813006302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813006303 putative active site [active] 1033813006304 heme pocket [chemical binding]; other site 1033813006305 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813006306 metal binding site [ion binding]; metal-binding site 1033813006307 active site 1033813006308 I-site; other site 1033813006309 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813006310 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1033813006311 AlkA N-terminal domain; Region: AlkA_N; smart01009 1033813006312 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1033813006313 minor groove reading motif; other site 1033813006314 helix-hairpin-helix signature motif; other site 1033813006315 substrate binding pocket [chemical binding]; other site 1033813006316 active site 1033813006317 putative chaperone; Provisional; Region: PRK11678 1033813006318 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1033813006319 nucleotide binding site [chemical binding]; other site 1033813006320 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1033813006321 SBD interface [polypeptide binding]; other site 1033813006322 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 1033813006323 Y-family of DNA polymerases; Region: PolY; cl12025 1033813006324 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1033813006325 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 1033813006326 metal ion-dependent adhesion site (MIDAS); other site 1033813006327 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1033813006328 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813006329 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813006330 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1033813006331 Protein export membrane protein; Region: SecD_SecF; cl14618 1033813006332 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1033813006333 putative transporter; Provisional; Region: PRK10504 1033813006334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813006335 putative substrate translocation pore; other site 1033813006336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1033813006337 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1033813006338 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033813006339 dimerization interface [polypeptide binding]; other site 1033813006340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813006341 dimer interface [polypeptide binding]; other site 1033813006342 phosphorylation site [posttranslational modification] 1033813006343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813006344 ATP binding site [chemical binding]; other site 1033813006345 Mg2+ binding site [ion binding]; other site 1033813006346 G-X-G motif; other site 1033813006347 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1033813006348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813006349 active site 1033813006350 phosphorylation site [posttranslational modification] 1033813006351 intermolecular recognition site; other site 1033813006352 dimerization interface [polypeptide binding]; other site 1033813006353 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813006354 DNA binding site [nucleotide binding] 1033813006355 Uncharacterized conserved protein [Function unknown]; Region: COG3422 1033813006356 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1033813006357 putative protease; Provisional; Region: PRK15452 1033813006358 Peptidase family U32; Region: Peptidase_U32; pfam01136 1033813006359 lipid kinase; Reviewed; Region: PRK13054 1033813006360 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1033813006361 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1033813006362 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1033813006363 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813006364 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 1033813006365 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1033813006366 putative NAD(P) binding site [chemical binding]; other site 1033813006367 catalytic Zn binding site [ion binding]; other site 1033813006368 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1033813006369 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1033813006370 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1033813006371 active site 1033813006372 P-loop; other site 1033813006373 phosphorylation site [posttranslational modification] 1033813006374 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033813006375 active site 1033813006376 phosphorylation site [posttranslational modification] 1033813006377 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 1033813006378 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1033813006379 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1033813006380 intersubunit interface [polypeptide binding]; other site 1033813006381 active site 1033813006382 zinc binding site [ion binding]; other site 1033813006383 Na+ binding site [ion binding]; other site 1033813006384 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1033813006385 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1033813006386 putative active site; other site 1033813006387 catalytic residue [active] 1033813006388 nucleoside transporter; Region: 2A0110; TIGR00889 1033813006389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813006390 putative substrate translocation pore; other site 1033813006391 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1033813006392 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1033813006393 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1033813006394 substrate binding site [chemical binding]; other site 1033813006395 ATP binding site [chemical binding]; other site 1033813006396 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1033813006397 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813006398 DNA-binding site [nucleotide binding]; DNA binding site 1033813006399 UTRA domain; Region: UTRA; pfam07702 1033813006400 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1033813006401 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 1033813006402 active site 1033813006403 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1033813006404 dimer interface [polypeptide binding]; other site 1033813006405 substrate binding site [chemical binding]; other site 1033813006406 ATP binding site [chemical binding]; other site 1033813006407 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1033813006408 substrate binding site [chemical binding]; other site 1033813006409 multimerization interface [polypeptide binding]; other site 1033813006410 ATP binding site [chemical binding]; other site 1033813006411 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1033813006412 putative metal binding site [ion binding]; other site 1033813006413 putative homodimer interface [polypeptide binding]; other site 1033813006414 putative homotetramer interface [polypeptide binding]; other site 1033813006415 putative homodimer-homodimer interface [polypeptide binding]; other site 1033813006416 putative allosteric switch controlling residues; other site 1033813006417 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1033813006418 Predicted integral membrane protein [Function unknown]; Region: COG5455 1033813006419 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1033813006420 PapC C-terminal domain; Region: PapC_C; pfam13953 1033813006421 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 1033813006422 antiporter inner membrane protein; Provisional; Region: PRK11670 1033813006423 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1033813006424 Walker A motif; other site 1033813006425 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1033813006426 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1033813006427 active site 1033813006428 HIGH motif; other site 1033813006429 KMSKS motif; other site 1033813006430 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1033813006431 tRNA binding surface [nucleotide binding]; other site 1033813006432 anticodon binding site; other site 1033813006433 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1033813006434 dimer interface [polypeptide binding]; other site 1033813006435 putative tRNA-binding site [nucleotide binding]; other site 1033813006436 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1033813006437 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1033813006438 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1033813006439 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1033813006440 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1033813006441 MoxR-like ATPases [General function prediction only]; Region: COG0714 1033813006442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813006443 Walker A motif; other site 1033813006444 ATP binding site [chemical binding]; other site 1033813006445 Walker B motif; other site 1033813006446 arginine finger; other site 1033813006447 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1033813006448 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1033813006449 metal ion-dependent adhesion site (MIDAS); other site 1033813006450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1033813006451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1033813006452 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1033813006453 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1033813006454 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1033813006455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813006456 active site 1033813006457 phosphorylation site [posttranslational modification] 1033813006458 intermolecular recognition site; other site 1033813006459 dimerization interface [polypeptide binding]; other site 1033813006460 LytTr DNA-binding domain; Region: LytTR; pfam04397 1033813006461 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1033813006462 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1033813006463 GAF domain; Region: GAF; pfam01590 1033813006464 Histidine kinase; Region: His_kinase; pfam06580 1033813006465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813006466 ATP binding site [chemical binding]; other site 1033813006467 Mg2+ binding site [ion binding]; other site 1033813006468 G-X-G motif; other site 1033813006469 transcriptional regulator MirA; Provisional; Region: PRK15043 1033813006470 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1033813006471 DNA binding residues [nucleotide binding] 1033813006472 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1033813006473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813006474 dimer interface [polypeptide binding]; other site 1033813006475 conserved gate region; other site 1033813006476 putative PBP binding loops; other site 1033813006477 ABC-ATPase subunit interface; other site 1033813006478 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1033813006479 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1033813006480 Walker A/P-loop; other site 1033813006481 ATP binding site [chemical binding]; other site 1033813006482 Q-loop/lid; other site 1033813006483 ABC transporter signature motif; other site 1033813006484 Walker B; other site 1033813006485 D-loop; other site 1033813006486 H-loop/switch region; other site 1033813006487 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1033813006488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813006489 dimer interface [polypeptide binding]; other site 1033813006490 conserved gate region; other site 1033813006491 ABC-ATPase subunit interface; other site 1033813006492 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1033813006493 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1033813006494 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1033813006495 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1033813006496 D-lactate dehydrogenase; Provisional; Region: PRK11183 1033813006497 FAD binding domain; Region: FAD_binding_4; pfam01565 1033813006498 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1033813006499 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1033813006500 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1033813006501 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1033813006502 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1033813006503 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1033813006504 oxidoreductase; Provisional; Region: PRK12743 1033813006505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1033813006506 NAD(P) binding site [chemical binding]; other site 1033813006507 active site 1033813006508 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1033813006509 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1033813006510 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1033813006511 FMN binding site [chemical binding]; other site 1033813006512 active site 1033813006513 catalytic residues [active] 1033813006514 substrate binding site [chemical binding]; other site 1033813006515 hypothetical protein; Provisional; Region: PRK01821 1033813006516 hypothetical protein; Provisional; Region: PRK10711 1033813006517 cytidine deaminase; Provisional; Region: PRK09027 1033813006518 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1033813006519 active site 1033813006520 catalytic motif [active] 1033813006521 Zn binding site [ion binding]; other site 1033813006522 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1033813006523 active site 1033813006524 catalytic motif [active] 1033813006525 Zn binding site [ion binding]; other site 1033813006526 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1033813006527 putative active site [active] 1033813006528 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 1033813006529 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1033813006530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1033813006531 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813006532 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1033813006533 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1033813006534 homodimer interface [polypeptide binding]; other site 1033813006535 active site 1033813006536 FMN binding site [chemical binding]; other site 1033813006537 substrate binding site [chemical binding]; other site 1033813006538 4Fe-4S binding domain; Region: Fer4; pfam00037 1033813006539 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033813006540 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1033813006541 TM-ABC transporter signature motif; other site 1033813006542 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1033813006543 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1033813006544 Walker A/P-loop; other site 1033813006545 ATP binding site [chemical binding]; other site 1033813006546 Q-loop/lid; other site 1033813006547 ABC transporter signature motif; other site 1033813006548 Walker B; other site 1033813006549 D-loop; other site 1033813006550 H-loop/switch region; other site 1033813006551 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1033813006552 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1033813006553 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1033813006554 ligand binding site [chemical binding]; other site 1033813006555 calcium binding site [ion binding]; other site 1033813006556 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1033813006557 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813006558 DNA binding site [nucleotide binding] 1033813006559 domain linker motif; other site 1033813006560 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1033813006561 dimerization interface (closed form) [polypeptide binding]; other site 1033813006562 ligand binding site [chemical binding]; other site 1033813006563 Predicted membrane protein [Function unknown]; Region: COG2311 1033813006564 hypothetical protein; Provisional; Region: PRK10835 1033813006565 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1033813006566 S-formylglutathione hydrolase; Region: PLN02442 1033813006567 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 1033813006568 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813006569 N-terminal plug; other site 1033813006570 ligand-binding site [chemical binding]; other site 1033813006571 lysine transporter; Provisional; Region: PRK10836 1033813006572 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1033813006573 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813006574 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1033813006575 putative dimerization interface [polypeptide binding]; other site 1033813006576 conserved hypothetical integral membrane protein; Region: TIGR00698 1033813006577 endonuclease IV; Provisional; Region: PRK01060 1033813006578 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1033813006579 AP (apurinic/apyrimidinic) site pocket; other site 1033813006580 DNA interaction; other site 1033813006581 Metal-binding active site; metal-binding site 1033813006582 putative kinase; Provisional; Region: PRK09954 1033813006583 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1033813006584 putative DNA binding site [nucleotide binding]; other site 1033813006585 putative Zn2+ binding site [ion binding]; other site 1033813006586 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1033813006587 substrate binding site [chemical binding]; other site 1033813006588 ATP binding site [chemical binding]; other site 1033813006589 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1033813006590 active site 1033813006591 tetramer interface [polypeptide binding]; other site 1033813006592 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1033813006593 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1033813006594 ligand binding site [chemical binding]; other site 1033813006595 flexible hinge region; other site 1033813006596 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1033813006597 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1033813006598 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1033813006599 Nucleoside recognition; Region: Gate; pfam07670 1033813006600 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1033813006601 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1033813006602 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1033813006603 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1033813006604 substrate binding site [chemical binding]; other site 1033813006605 ATP binding site [chemical binding]; other site 1033813006606 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1033813006607 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1033813006608 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1033813006609 active site 1033813006610 P-loop; other site 1033813006611 phosphorylation site [posttranslational modification] 1033813006612 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1033813006613 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1033813006614 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1033813006615 putative substrate binding site [chemical binding]; other site 1033813006616 putative ATP binding site [chemical binding]; other site 1033813006617 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1033813006618 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033813006619 active site 1033813006620 phosphorylation site [posttranslational modification] 1033813006621 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1033813006622 dimerization domain swap beta strand [polypeptide binding]; other site 1033813006623 regulatory protein interface [polypeptide binding]; other site 1033813006624 active site 1033813006625 regulatory phosphorylation site [posttranslational modification]; other site 1033813006626 sugar efflux transporter B; Provisional; Region: PRK15011 1033813006627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813006628 putative substrate translocation pore; other site 1033813006629 elongation factor P; Provisional; Region: PRK04542 1033813006630 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1033813006631 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1033813006632 RNA binding site [nucleotide binding]; other site 1033813006633 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1033813006634 RNA binding site [nucleotide binding]; other site 1033813006635 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1033813006636 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1033813006637 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1033813006638 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1033813006639 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1033813006640 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1033813006641 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1033813006642 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1033813006643 active site 1033813006644 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1033813006645 NlpC/P60 family; Region: NLPC_P60; pfam00877 1033813006646 phage resistance protein; Provisional; Region: PRK10551 1033813006647 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1033813006648 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813006649 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1033813006650 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1033813006651 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1033813006652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813006653 dimer interface [polypeptide binding]; other site 1033813006654 conserved gate region; other site 1033813006655 ABC-ATPase subunit interface; other site 1033813006656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1033813006657 microcin C ABC transporter permease; Provisional; Region: PRK15021 1033813006658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813006659 dimer interface [polypeptide binding]; other site 1033813006660 conserved gate region; other site 1033813006661 ABC-ATPase subunit interface; other site 1033813006662 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1033813006663 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813006664 Walker A/P-loop; other site 1033813006665 ATP binding site [chemical binding]; other site 1033813006666 Q-loop/lid; other site 1033813006667 ABC transporter signature motif; other site 1033813006668 Walker B; other site 1033813006669 D-loop; other site 1033813006670 H-loop/switch region; other site 1033813006671 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1033813006672 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813006673 Walker A/P-loop; other site 1033813006674 ATP binding site [chemical binding]; other site 1033813006675 Q-loop/lid; other site 1033813006676 ABC transporter signature motif; other site 1033813006677 Walker B; other site 1033813006678 D-loop; other site 1033813006679 H-loop/switch region; other site 1033813006680 hypothetical protein; Provisional; Region: PRK11835 1033813006681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813006682 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1033813006683 putative substrate translocation pore; other site 1033813006684 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1033813006685 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033813006686 RNA binding surface [nucleotide binding]; other site 1033813006687 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1033813006688 active site 1033813006689 uracil binding [chemical binding]; other site 1033813006690 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1033813006691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033813006692 ATP binding site [chemical binding]; other site 1033813006693 putative Mg++ binding site [ion binding]; other site 1033813006694 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813006695 nucleotide binding region [chemical binding]; other site 1033813006696 ATP-binding site [chemical binding]; other site 1033813006697 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 1033813006698 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1033813006699 5S rRNA interface [nucleotide binding]; other site 1033813006700 CTC domain interface [polypeptide binding]; other site 1033813006701 L16 interface [polypeptide binding]; other site 1033813006702 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1033813006703 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1033813006704 hypothetical protein; Provisional; Region: PRK13689 1033813006705 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1033813006706 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1033813006707 Sulfatase; Region: Sulfatase; pfam00884 1033813006708 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 1033813006709 transcriptional regulator NarP; Provisional; Region: PRK10403 1033813006710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813006711 active site 1033813006712 phosphorylation site [posttranslational modification] 1033813006713 intermolecular recognition site; other site 1033813006714 dimerization interface [polypeptide binding]; other site 1033813006715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813006716 DNA binding residues [nucleotide binding] 1033813006717 dimerization interface [polypeptide binding]; other site 1033813006718 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1033813006719 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1033813006720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1033813006721 binding surface 1033813006722 TPR motif; other site 1033813006723 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1033813006724 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1033813006725 catalytic residues [active] 1033813006726 central insert; other site 1033813006727 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1033813006728 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1033813006729 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1033813006730 heme exporter protein CcmC; Region: ccmC; TIGR01191 1033813006731 heme exporter protein CcmB; Region: ccmB; TIGR01190 1033813006732 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1033813006733 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1033813006734 Walker A/P-loop; other site 1033813006735 ATP binding site [chemical binding]; other site 1033813006736 Q-loop/lid; other site 1033813006737 ABC transporter signature motif; other site 1033813006738 Walker B; other site 1033813006739 D-loop; other site 1033813006740 H-loop/switch region; other site 1033813006741 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1033813006742 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1033813006743 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1033813006744 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1033813006745 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1033813006746 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1033813006747 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1033813006748 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1033813006749 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1033813006750 [4Fe-4S] binding site [ion binding]; other site 1033813006751 molybdopterin cofactor binding site; other site 1033813006752 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1033813006753 molybdopterin cofactor binding site; other site 1033813006754 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1033813006755 ferredoxin-type protein; Provisional; Region: PRK10194 1033813006756 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 1033813006757 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1033813006758 secondary substrate binding site; other site 1033813006759 primary substrate binding site; other site 1033813006760 inhibition loop; other site 1033813006761 dimerization interface [polypeptide binding]; other site 1033813006762 malate:quinone oxidoreductase; Validated; Region: PRK05257 1033813006763 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1033813006764 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1033813006765 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1033813006766 Walker A/P-loop; other site 1033813006767 ATP binding site [chemical binding]; other site 1033813006768 Q-loop/lid; other site 1033813006769 ABC transporter signature motif; other site 1033813006770 Walker B; other site 1033813006771 D-loop; other site 1033813006772 H-loop/switch region; other site 1033813006773 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1033813006774 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1033813006775 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1033813006776 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813006777 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1033813006778 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1033813006779 DNA binding site [nucleotide binding] 1033813006780 active site 1033813006781 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1033813006782 ApbE family; Region: ApbE; pfam02424 1033813006783 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1033813006784 outer membrane porin protein C; Provisional; Region: PRK10554 1033813006785 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1033813006786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813006787 ATP binding site [chemical binding]; other site 1033813006788 G-X-G motif; other site 1033813006789 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1033813006790 putative binding surface; other site 1033813006791 active site 1033813006792 transcriptional regulator RcsB; Provisional; Region: PRK10840 1033813006793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813006794 active site 1033813006795 phosphorylation site [posttranslational modification] 1033813006796 intermolecular recognition site; other site 1033813006797 dimerization interface [polypeptide binding]; other site 1033813006798 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813006799 DNA binding residues [nucleotide binding] 1033813006800 dimerization interface [polypeptide binding]; other site 1033813006801 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1033813006802 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813006803 dimer interface [polypeptide binding]; other site 1033813006804 phosphorylation site [posttranslational modification] 1033813006805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813006806 ATP binding site [chemical binding]; other site 1033813006807 Mg2+ binding site [ion binding]; other site 1033813006808 G-X-G motif; other site 1033813006809 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1033813006810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813006811 active site 1033813006812 phosphorylation site [posttranslational modification] 1033813006813 intermolecular recognition site; other site 1033813006814 dimerization interface [polypeptide binding]; other site 1033813006815 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1033813006816 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813006817 putative active site [active] 1033813006818 heme pocket [chemical binding]; other site 1033813006819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813006820 dimer interface [polypeptide binding]; other site 1033813006821 phosphorylation site [posttranslational modification] 1033813006822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813006823 ATP binding site [chemical binding]; other site 1033813006824 Mg2+ binding site [ion binding]; other site 1033813006825 G-X-G motif; other site 1033813006826 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 1033813006827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813006828 active site 1033813006829 phosphorylation site [posttranslational modification] 1033813006830 intermolecular recognition site; other site 1033813006831 dimerization interface [polypeptide binding]; other site 1033813006832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813006833 Walker A motif; other site 1033813006834 ATP binding site [chemical binding]; other site 1033813006835 Walker B motif; other site 1033813006836 arginine finger; other site 1033813006837 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1033813006838 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 1033813006839 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1033813006840 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 1033813006841 putative acyltransferase; Provisional; Region: PRK05790 1033813006842 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1033813006843 dimer interface [polypeptide binding]; other site 1033813006844 active site 1033813006845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1033813006846 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1033813006847 Predicted secreted protein [Function unknown]; Region: COG5445 1033813006848 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1033813006849 Predicted secreted protein [Function unknown]; Region: COG5445 1033813006850 Stage II sporulation protein; Region: SpoIID; pfam08486 1033813006851 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1033813006852 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1033813006853 MG2 domain; Region: A2M_N; pfam01835 1033813006854 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 1033813006855 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1033813006856 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1033813006857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 1033813006858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 1033813006859 DNA gyrase subunit A; Validated; Region: PRK05560 1033813006860 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1033813006861 CAP-like domain; other site 1033813006862 active site 1033813006863 primary dimer interface [polypeptide binding]; other site 1033813006864 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033813006865 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033813006866 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033813006867 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033813006868 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033813006869 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033813006870 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1033813006871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813006872 S-adenosylmethionine binding site [chemical binding]; other site 1033813006873 adhesin; Provisional; Region: PRK09752 1033813006874 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1033813006875 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1033813006876 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1033813006877 ATP cone domain; Region: ATP-cone; pfam03477 1033813006878 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1033813006879 active site 1033813006880 dimer interface [polypeptide binding]; other site 1033813006881 catalytic residues [active] 1033813006882 effector binding site; other site 1033813006883 R2 peptide binding site; other site 1033813006884 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1033813006885 dimer interface [polypeptide binding]; other site 1033813006886 putative radical transfer pathway; other site 1033813006887 diiron center [ion binding]; other site 1033813006888 tyrosyl radical; other site 1033813006889 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1033813006890 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1033813006891 catalytic loop [active] 1033813006892 iron binding site [ion binding]; other site 1033813006893 hypothetical protein; Provisional; Region: PRK09902 1033813006894 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1033813006895 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1033813006896 active site 1033813006897 catalytic site [active] 1033813006898 metal binding site [ion binding]; metal-binding site 1033813006899 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1033813006900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813006901 putative substrate translocation pore; other site 1033813006902 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1033813006903 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1033813006904 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1033813006905 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1033813006906 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1033813006907 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1033813006908 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1033813006909 Cysteine-rich domain; Region: CCG; pfam02754 1033813006910 Cysteine-rich domain; Region: CCG; pfam02754 1033813006911 hypothetical protein; Provisional; Region: PRK09956 1033813006912 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1033813006913 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 1033813006914 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1033813006915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813006916 putative substrate translocation pore; other site 1033813006917 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1033813006918 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1033813006919 putative active site pocket [active] 1033813006920 putative metal binding site [ion binding]; other site 1033813006921 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1033813006922 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1033813006923 Bacterial transcriptional regulator; Region: IclR; pfam01614 1033813006924 hypothetical protein; Provisional; Region: PRK03673 1033813006925 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1033813006926 putative MPT binding site; other site 1033813006927 Competence-damaged protein; Region: CinA; cl00666 1033813006928 YfaZ precursor; Region: YfaZ; pfam07437 1033813006929 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1033813006930 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1033813006931 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1033813006932 catalytic core [active] 1033813006933 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1033813006934 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1033813006935 inhibitor-cofactor binding pocket; inhibition site 1033813006936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813006937 catalytic residue [active] 1033813006938 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1033813006939 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1033813006940 Ligand binding site; other site 1033813006941 Putative Catalytic site; other site 1033813006942 DXD motif; other site 1033813006943 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1033813006944 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 1033813006945 substrate binding site [chemical binding]; other site 1033813006946 cosubstrate binding site; other site 1033813006947 catalytic site [active] 1033813006948 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1033813006949 active site 1033813006950 hexamer interface [polypeptide binding]; other site 1033813006951 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1033813006952 NAD binding site [chemical binding]; other site 1033813006953 substrate binding site [chemical binding]; other site 1033813006954 active site 1033813006955 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1033813006956 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1033813006957 putative active site [active] 1033813006958 putative catalytic site [active] 1033813006959 putative Zn binding site [ion binding]; other site 1033813006960 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1033813006961 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1033813006962 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1033813006963 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1033813006964 signal transduction protein PmrD; Provisional; Region: PRK15450 1033813006965 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1033813006966 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1033813006967 acyl-activating enzyme (AAE) consensus motif; other site 1033813006968 putative AMP binding site [chemical binding]; other site 1033813006969 putative active site [active] 1033813006970 putative CoA binding site [chemical binding]; other site 1033813006971 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1033813006972 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1033813006973 active site 1033813006974 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1033813006975 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1033813006976 substrate binding site [chemical binding]; other site 1033813006977 oxyanion hole (OAH) forming residues; other site 1033813006978 trimer interface [polypeptide binding]; other site 1033813006979 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1033813006980 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1033813006981 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1033813006982 dimer interface [polypeptide binding]; other site 1033813006983 tetramer interface [polypeptide binding]; other site 1033813006984 PYR/PP interface [polypeptide binding]; other site 1033813006985 TPP binding site [chemical binding]; other site 1033813006986 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1033813006987 TPP-binding site; other site 1033813006988 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1033813006989 isochorismate synthases; Region: isochor_syn; TIGR00543 1033813006990 hypothetical protein; Provisional; Region: PRK10404 1033813006991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813006992 Coenzyme A binding pocket [chemical binding]; other site 1033813006993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1033813006994 von Willebrand factor; Region: vWF_A; pfam12450 1033813006995 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1033813006996 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1033813006997 metal ion-dependent adhesion site (MIDAS); other site 1033813006998 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1033813006999 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1033813007000 M28 Zn-Peptidases; Region: M28_like_1; cd05640 1033813007001 metal binding site [ion binding]; metal-binding site 1033813007002 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1033813007003 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1033813007004 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1033813007005 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1033813007006 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1033813007007 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1033813007008 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1033813007009 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1033813007010 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1033813007011 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1033813007012 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1033813007013 4Fe-4S binding domain; Region: Fer4; pfam00037 1033813007014 4Fe-4S binding domain; Region: Fer4; pfam00037 1033813007015 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1033813007016 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1033813007017 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1033813007018 catalytic loop [active] 1033813007019 iron binding site [ion binding]; other site 1033813007020 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1033813007021 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1033813007022 [4Fe-4S] binding site [ion binding]; other site 1033813007023 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1033813007024 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1033813007025 SLBB domain; Region: SLBB; pfam10531 1033813007026 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1033813007027 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1033813007028 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1033813007029 putative dimer interface [polypeptide binding]; other site 1033813007030 [2Fe-2S] cluster binding site [ion binding]; other site 1033813007031 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1033813007032 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1033813007033 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1033813007034 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1033813007035 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1033813007036 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1033813007037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813007038 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1033813007039 putative dimerization interface [polypeptide binding]; other site 1033813007040 aminotransferase AlaT; Validated; Region: PRK09265 1033813007041 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1033813007042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813007043 homodimer interface [polypeptide binding]; other site 1033813007044 catalytic residue [active] 1033813007045 5'-nucleotidase; Provisional; Region: PRK03826 1033813007046 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1033813007047 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1033813007048 TrkA-C domain; Region: TrkA_C; pfam02080 1033813007049 TrkA-C domain; Region: TrkA_C; pfam02080 1033813007050 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1033813007051 putative phosphatase; Provisional; Region: PRK11587 1033813007052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813007053 motif II; other site 1033813007054 hypothetical protein; Validated; Region: PRK05445 1033813007055 hypothetical protein; Provisional; Region: PRK01816 1033813007056 propionate/acetate kinase; Provisional; Region: PRK12379 1033813007057 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1033813007058 phosphate acetyltransferase; Reviewed; Region: PRK05632 1033813007059 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1033813007060 DRTGG domain; Region: DRTGG; pfam07085 1033813007061 phosphate acetyltransferase; Region: pta; TIGR00651 1033813007062 hypothetical protein; Provisional; Region: PRK11588 1033813007063 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1033813007064 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1033813007065 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1033813007066 nudix motif; other site 1033813007067 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1033813007068 active site 1033813007069 metal binding site [ion binding]; metal-binding site 1033813007070 homotetramer interface [polypeptide binding]; other site 1033813007071 glutathione S-transferase; Provisional; Region: PRK15113 1033813007072 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1033813007073 C-terminal domain interface [polypeptide binding]; other site 1033813007074 GSH binding site (G-site) [chemical binding]; other site 1033813007075 dimer interface [polypeptide binding]; other site 1033813007076 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1033813007077 N-terminal domain interface [polypeptide binding]; other site 1033813007078 putative dimer interface [polypeptide binding]; other site 1033813007079 putative substrate binding pocket (H-site) [chemical binding]; other site 1033813007080 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1033813007081 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1033813007082 C-terminal domain interface [polypeptide binding]; other site 1033813007083 GSH binding site (G-site) [chemical binding]; other site 1033813007084 dimer interface [polypeptide binding]; other site 1033813007085 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1033813007086 N-terminal domain interface [polypeptide binding]; other site 1033813007087 putative dimer interface [polypeptide binding]; other site 1033813007088 active site 1033813007089 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1033813007090 homooctamer interface [polypeptide binding]; other site 1033813007091 active site 1033813007092 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1033813007093 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1033813007094 putative NAD(P) binding site [chemical binding]; other site 1033813007095 putative active site [active] 1033813007096 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1033813007097 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1033813007098 Walker A/P-loop; other site 1033813007099 ATP binding site [chemical binding]; other site 1033813007100 Q-loop/lid; other site 1033813007101 ABC transporter signature motif; other site 1033813007102 Walker B; other site 1033813007103 D-loop; other site 1033813007104 H-loop/switch region; other site 1033813007105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813007106 dimer interface [polypeptide binding]; other site 1033813007107 conserved gate region; other site 1033813007108 putative PBP binding loops; other site 1033813007109 ABC-ATPase subunit interface; other site 1033813007110 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1033813007111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813007112 dimer interface [polypeptide binding]; other site 1033813007113 conserved gate region; other site 1033813007114 putative PBP binding loops; other site 1033813007115 ABC-ATPase subunit interface; other site 1033813007116 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1033813007117 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813007118 substrate binding pocket [chemical binding]; other site 1033813007119 membrane-bound complex binding site; other site 1033813007120 hinge residues; other site 1033813007121 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1033813007122 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813007123 substrate binding pocket [chemical binding]; other site 1033813007124 membrane-bound complex binding site; other site 1033813007125 hinge residues; other site 1033813007126 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1033813007127 Flavoprotein; Region: Flavoprotein; pfam02441 1033813007128 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1033813007129 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1033813007130 active site 1033813007131 tetramer interface [polypeptide binding]; other site 1033813007132 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033813007133 active site 1033813007134 colicin V production protein; Provisional; Region: PRK10845 1033813007135 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1033813007136 cell division protein DedD; Provisional; Region: PRK11633 1033813007137 Sporulation related domain; Region: SPOR; pfam05036 1033813007138 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1033813007139 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1033813007140 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1033813007141 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1033813007142 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1033813007143 hypothetical protein; Provisional; Region: PRK10847 1033813007144 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1033813007145 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1033813007146 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1033813007147 dimerization interface 3.5A [polypeptide binding]; other site 1033813007148 active site 1033813007149 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1033813007150 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1033813007151 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1033813007152 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1033813007153 ligand binding site [chemical binding]; other site 1033813007154 NAD binding site [chemical binding]; other site 1033813007155 catalytic site [active] 1033813007156 homodimer interface [polypeptide binding]; other site 1033813007157 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1033813007158 putative transporter; Provisional; Region: PRK12382 1033813007159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813007160 putative substrate translocation pore; other site 1033813007161 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1033813007162 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1033813007163 dimer interface [polypeptide binding]; other site 1033813007164 active site 1033813007165 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1033813007166 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1033813007167 YfcL protein; Region: YfcL; pfam08891 1033813007168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1033813007169 hypothetical protein; Provisional; Region: PRK10621 1033813007170 Predicted permeases [General function prediction only]; Region: COG0730 1033813007171 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1033813007172 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1033813007173 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1033813007174 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1033813007175 Tetramer interface [polypeptide binding]; other site 1033813007176 active site 1033813007177 FMN-binding site [chemical binding]; other site 1033813007178 HemK family putative methylases; Region: hemK_fam; TIGR00536 1033813007179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813007180 S-adenosylmethionine binding site [chemical binding]; other site 1033813007181 hypothetical protein; Provisional; Region: PRK04946 1033813007182 Smr domain; Region: Smr; pfam01713 1033813007183 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 1033813007184 Fimbrial protein; Region: Fimbrial; cl01416 1033813007185 Fimbrial protein; Region: Fimbrial; cl01416 1033813007186 Fimbrial protein; Region: Fimbrial; cl01416 1033813007187 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 1033813007188 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1033813007189 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1033813007190 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1033813007191 PapC N-terminal domain; Region: PapC_N; pfam13954 1033813007192 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1033813007193 PapC C-terminal domain; Region: PapC_C; pfam13953 1033813007194 Fimbrial protein; Region: Fimbrial; cl01416 1033813007195 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033813007196 catalytic core [active] 1033813007197 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1033813007198 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1033813007199 substrate binding site [chemical binding]; other site 1033813007200 oxyanion hole (OAH) forming residues; other site 1033813007201 trimer interface [polypeptide binding]; other site 1033813007202 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1033813007203 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1033813007204 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1033813007205 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1033813007206 dimer interface [polypeptide binding]; other site 1033813007207 active site 1033813007208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1033813007209 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1033813007210 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1033813007211 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1033813007212 integrase; Provisional; Region: PRK09692 1033813007213 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1033813007214 active site 1033813007215 Int/Topo IB signature motif; other site 1033813007216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1033813007217 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1033813007218 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1033813007219 active site 1033813007220 metal binding site [ion binding]; metal-binding site 1033813007221 interdomain interaction site; other site 1033813007222 Domain of unknown function (DUF927); Region: DUF927; pfam06048 1033813007223 Ash protein family; Region: Phage_ASH; pfam10554 1033813007224 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 1033813007225 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1033813007226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813007227 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1033813007228 dimerization interface [polypeptide binding]; other site 1033813007229 substrate binding pocket [chemical binding]; other site 1033813007230 permease DsdX; Provisional; Region: PRK09921 1033813007231 gluconate transporter; Region: gntP; TIGR00791 1033813007232 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1033813007233 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1033813007234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1033813007235 catalytic residue [active] 1033813007236 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1033813007237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813007238 putative substrate translocation pore; other site 1033813007239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813007240 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1033813007241 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 1033813007242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813007243 active site 1033813007244 phosphorylation site [posttranslational modification] 1033813007245 intermolecular recognition site; other site 1033813007246 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813007247 DNA binding residues [nucleotide binding] 1033813007248 dimerization interface [polypeptide binding]; other site 1033813007249 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1033813007250 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813007251 substrate binding pocket [chemical binding]; other site 1033813007252 membrane-bound complex binding site; other site 1033813007253 hinge residues; other site 1033813007254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813007255 substrate binding pocket [chemical binding]; other site 1033813007256 membrane-bound complex binding site; other site 1033813007257 hinge residues; other site 1033813007258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813007259 dimer interface [polypeptide binding]; other site 1033813007260 phosphorylation site [posttranslational modification] 1033813007261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813007262 ATP binding site [chemical binding]; other site 1033813007263 Mg2+ binding site [ion binding]; other site 1033813007264 G-X-G motif; other site 1033813007265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813007266 active site 1033813007267 phosphorylation site [posttranslational modification] 1033813007268 intermolecular recognition site; other site 1033813007269 dimerization interface [polypeptide binding]; other site 1033813007270 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1033813007271 putative binding surface; other site 1033813007272 active site 1033813007273 putative CoA-transferase; Provisional; Region: PRK11430 1033813007274 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1033813007275 putative transporter YfdV; Provisional; Region: PRK09903 1033813007276 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1033813007277 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1033813007278 PYR/PP interface [polypeptide binding]; other site 1033813007279 dimer interface [polypeptide binding]; other site 1033813007280 TPP binding site [chemical binding]; other site 1033813007281 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1033813007282 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1033813007283 TPP-binding site; other site 1033813007284 dimer interface [polypeptide binding]; other site 1033813007285 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1033813007286 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1033813007287 hypothetical protein; Provisional; Region: PRK10316 1033813007288 YfdX protein; Region: YfdX; pfam10938 1033813007289 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 1033813007290 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1033813007291 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1033813007292 putative acyl-acceptor binding pocket; other site 1033813007293 aminotransferase; Validated; Region: PRK08175 1033813007294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1033813007295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813007296 homodimer interface [polypeptide binding]; other site 1033813007297 catalytic residue [active] 1033813007298 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1033813007299 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1033813007300 GAF domain; Region: GAF; cl17456 1033813007301 Histidine kinase; Region: His_kinase; pfam06580 1033813007302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813007303 ATP binding site [chemical binding]; other site 1033813007304 Mg2+ binding site [ion binding]; other site 1033813007305 G-X-G motif; other site 1033813007306 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1033813007307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813007308 active site 1033813007309 phosphorylation site [posttranslational modification] 1033813007310 intermolecular recognition site; other site 1033813007311 dimerization interface [polypeptide binding]; other site 1033813007312 LytTr DNA-binding domain; Region: LytTR; pfam04397 1033813007313 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1033813007314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813007315 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1033813007316 dimerization domain swap beta strand [polypeptide binding]; other site 1033813007317 regulatory protein interface [polypeptide binding]; other site 1033813007318 active site 1033813007319 regulatory phosphorylation site [posttranslational modification]; other site 1033813007320 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1033813007321 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1033813007322 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1033813007323 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1033813007324 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033813007325 active site 1033813007326 phosphorylation site [posttranslational modification] 1033813007327 exoaminopeptidase; Provisional; Region: PRK09961 1033813007328 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 1033813007329 oligomer interface [polypeptide binding]; other site 1033813007330 active site 1033813007331 metal binding site [ion binding]; metal-binding site 1033813007332 aminopeptidase; Provisional; Region: PRK09795 1033813007333 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1033813007334 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1033813007335 active site 1033813007336 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1033813007337 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1033813007338 active site 1033813007339 P-loop; other site 1033813007340 phosphorylation site [posttranslational modification] 1033813007341 glucokinase, proteobacterial type; Region: glk; TIGR00749 1033813007342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033813007343 nucleotide binding site [chemical binding]; other site 1033813007344 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1033813007345 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1033813007346 Cl- selectivity filter; other site 1033813007347 Cl- binding residues [ion binding]; other site 1033813007348 pore gating glutamate residue; other site 1033813007349 dimer interface [polypeptide binding]; other site 1033813007350 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1033813007351 manganese transport protein MntH; Reviewed; Region: PRK00701 1033813007352 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1033813007353 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1033813007354 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1033813007355 Nucleoside recognition; Region: Gate; pfam07670 1033813007356 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1033813007357 MASE1; Region: MASE1; pfam05231 1033813007358 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1033813007359 diguanylate cyclase; Region: GGDEF; smart00267 1033813007360 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813007361 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1033813007362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813007363 salt bridge; other site 1033813007364 non-specific DNA binding site [nucleotide binding]; other site 1033813007365 sequence-specific DNA binding site [nucleotide binding]; other site 1033813007366 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1033813007367 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1033813007368 active site 1033813007369 HIGH motif; other site 1033813007370 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1033813007371 active site 1033813007372 KMSKS motif; other site 1033813007373 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1033813007374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813007375 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1033813007376 putative dimerization interface [polypeptide binding]; other site 1033813007377 putative substrate binding pocket [chemical binding]; other site 1033813007378 XapX domain; Region: XapX; TIGR03510 1033813007379 nucleoside transporter; Region: 2A0110; TIGR00889 1033813007380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813007381 putative substrate translocation pore; other site 1033813007382 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1033813007383 hypothetical protein; Provisional; Region: PRK11528 1033813007384 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033813007385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813007386 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1033813007387 putative dimerization interface [polypeptide binding]; other site 1033813007388 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1033813007389 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1033813007390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1033813007391 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1033813007392 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1033813007393 nucleotide binding pocket [chemical binding]; other site 1033813007394 K-X-D-G motif; other site 1033813007395 catalytic site [active] 1033813007396 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1033813007397 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1033813007398 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1033813007399 Dimer interface [polypeptide binding]; other site 1033813007400 BRCT sequence motif; other site 1033813007401 cell division protein ZipA; Provisional; Region: PRK03427 1033813007402 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1033813007403 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1033813007404 FtsZ protein binding site [polypeptide binding]; other site 1033813007405 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1033813007406 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1033813007407 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1033813007408 dimer interface [polypeptide binding]; other site 1033813007409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813007410 catalytic residue [active] 1033813007411 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1033813007412 dimerization domain swap beta strand [polypeptide binding]; other site 1033813007413 regulatory protein interface [polypeptide binding]; other site 1033813007414 active site 1033813007415 regulatory phosphorylation site [posttranslational modification]; other site 1033813007416 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1033813007417 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1033813007418 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1033813007419 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1033813007420 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1033813007421 HPr interaction site; other site 1033813007422 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1033813007423 active site 1033813007424 phosphorylation site [posttranslational modification] 1033813007425 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1033813007426 dimer interface [polypeptide binding]; other site 1033813007427 pyridoxamine kinase; Validated; Region: PRK05756 1033813007428 pyridoxal binding site [chemical binding]; other site 1033813007429 ATP binding site [chemical binding]; other site 1033813007430 hypothetical protein; Provisional; Region: PRK10318 1033813007431 cysteine synthase B; Region: cysM; TIGR01138 1033813007432 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1033813007433 dimer interface [polypeptide binding]; other site 1033813007434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813007435 catalytic residue [active] 1033813007436 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1033813007437 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1033813007438 Walker A/P-loop; other site 1033813007439 ATP binding site [chemical binding]; other site 1033813007440 Q-loop/lid; other site 1033813007441 ABC transporter signature motif; other site 1033813007442 Walker B; other site 1033813007443 D-loop; other site 1033813007444 H-loop/switch region; other site 1033813007445 TOBE-like domain; Region: TOBE_3; pfam12857 1033813007446 sulfate transport protein; Provisional; Region: cysT; CHL00187 1033813007447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813007448 dimer interface [polypeptide binding]; other site 1033813007449 conserved gate region; other site 1033813007450 putative PBP binding loops; other site 1033813007451 ABC-ATPase subunit interface; other site 1033813007452 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1033813007453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813007454 dimer interface [polypeptide binding]; other site 1033813007455 conserved gate region; other site 1033813007456 putative PBP binding loops; other site 1033813007457 ABC-ATPase subunit interface; other site 1033813007458 thiosulfate transporter subunit; Provisional; Region: PRK10852 1033813007459 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1033813007460 short chain dehydrogenase; Provisional; Region: PRK08226 1033813007461 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1033813007462 NAD binding site [chemical binding]; other site 1033813007463 homotetramer interface [polypeptide binding]; other site 1033813007464 homodimer interface [polypeptide binding]; other site 1033813007465 active site 1033813007466 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1033813007467 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1033813007468 putative active site [active] 1033813007469 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1033813007470 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1033813007471 active site turn [active] 1033813007472 phosphorylation site [posttranslational modification] 1033813007473 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1033813007474 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1033813007475 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1033813007476 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1033813007477 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1033813007478 putative acetyltransferase; Provisional; Region: PRK03624 1033813007479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813007480 Coenzyme A binding pocket [chemical binding]; other site 1033813007481 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1033813007482 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1033813007483 active site 1033813007484 metal binding site [ion binding]; metal-binding site 1033813007485 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1033813007486 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1033813007487 transcriptional regulator EutR; Provisional; Region: PRK10130 1033813007488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813007489 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813007490 carboxysome structural protein EutK; Provisional; Region: PRK15466 1033813007491 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1033813007492 Hexamer interface [polypeptide binding]; other site 1033813007493 Hexagonal pore residue; other site 1033813007494 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1033813007495 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1033813007496 putative hexamer interface [polypeptide binding]; other site 1033813007497 putative hexagonal pore; other site 1033813007498 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1033813007499 putative hexamer interface [polypeptide binding]; other site 1033813007500 putative hexagonal pore; other site 1033813007501 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1033813007502 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 1033813007503 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1033813007504 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1033813007505 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1033813007506 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 1033813007507 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 1033813007508 active site 1033813007509 metal binding site [ion binding]; metal-binding site 1033813007510 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 1033813007511 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033813007512 nucleotide binding site [chemical binding]; other site 1033813007513 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1033813007514 putative catalytic cysteine [active] 1033813007515 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1033813007516 Hexamer/Pentamer interface [polypeptide binding]; other site 1033813007517 central pore; other site 1033813007518 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1033813007519 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1033813007520 Hexamer interface [polypeptide binding]; other site 1033813007521 Putative hexagonal pore residue; other site 1033813007522 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1033813007523 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 1033813007524 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1033813007525 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 1033813007526 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1033813007527 G1 box; other site 1033813007528 GTP/Mg2+ binding site [chemical binding]; other site 1033813007529 G2 box; other site 1033813007530 Switch I region; other site 1033813007531 G3 box; other site 1033813007532 Switch II region; other site 1033813007533 G4 box; other site 1033813007534 G5 box; other site 1033813007535 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1033813007536 putative hexamer interface [polypeptide binding]; other site 1033813007537 putative hexagonal pore; other site 1033813007538 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1033813007539 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1033813007540 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1033813007541 putative NAD(P) binding site [chemical binding]; other site 1033813007542 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1033813007543 transaldolase-like protein; Provisional; Region: PTZ00411 1033813007544 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1033813007545 active site 1033813007546 dimer interface [polypeptide binding]; other site 1033813007547 catalytic residue [active] 1033813007548 transketolase; Reviewed; Region: PRK12753 1033813007549 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1033813007550 TPP-binding site [chemical binding]; other site 1033813007551 dimer interface [polypeptide binding]; other site 1033813007552 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1033813007553 PYR/PP interface [polypeptide binding]; other site 1033813007554 dimer interface [polypeptide binding]; other site 1033813007555 TPP binding site [chemical binding]; other site 1033813007556 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1033813007557 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1033813007558 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1033813007559 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1033813007560 dimer interface [polypeptide binding]; other site 1033813007561 ADP-ribose binding site [chemical binding]; other site 1033813007562 active site 1033813007563 nudix motif; other site 1033813007564 metal binding site [ion binding]; metal-binding site 1033813007565 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1033813007566 4Fe-4S binding domain; Region: Fer4; pfam00037 1033813007567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1033813007568 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813007569 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1033813007570 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1033813007571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033813007572 dimerization interface [polypeptide binding]; other site 1033813007573 Histidine kinase; Region: HisKA_3; pfam07730 1033813007574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813007575 ATP binding site [chemical binding]; other site 1033813007576 Mg2+ binding site [ion binding]; other site 1033813007577 G-X-G motif; other site 1033813007578 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1033813007579 Protein export membrane protein; Region: SecD_SecF; cl14618 1033813007580 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1033813007581 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1033813007582 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1033813007583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1033813007584 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1033813007585 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1033813007586 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1033813007587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1033813007588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1033813007589 DNA binding residues [nucleotide binding] 1033813007590 fec operon regulator FecR; Reviewed; Region: PRK09774 1033813007591 FecR protein; Region: FecR; pfam04773 1033813007592 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1033813007593 Secretin and TonB N terminus short domain; Region: STN; smart00965 1033813007594 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813007595 N-terminal plug; other site 1033813007596 ligand-binding site [chemical binding]; other site 1033813007597 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 1033813007598 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1033813007599 siderophore binding site; other site 1033813007600 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1033813007601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813007602 dimer interface [polypeptide binding]; other site 1033813007603 ABC-ATPase subunit interface; other site 1033813007604 putative PBP binding regions; other site 1033813007605 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1033813007606 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813007607 ABC-ATPase subunit interface; other site 1033813007608 dimer interface [polypeptide binding]; other site 1033813007609 putative PBP binding regions; other site 1033813007610 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 1033813007611 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1033813007612 ABC transporter signature motif; other site 1033813007613 Walker B; other site 1033813007614 D-loop; other site 1033813007615 H-loop/switch region; other site 1033813007616 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1033813007617 Integrase core domain; Region: rve; pfam00665 1033813007618 Integrase core domain; Region: rve_3; pfam13683 1033813007619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1033813007620 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1033813007621 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1033813007622 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1033813007623 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1033813007624 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1033813007625 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1033813007626 ArsC family; Region: ArsC; pfam03960 1033813007627 putative catalytic residues [active] 1033813007628 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1033813007629 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1033813007630 metal binding site [ion binding]; metal-binding site 1033813007631 dimer interface [polypeptide binding]; other site 1033813007632 hypothetical protein; Provisional; Region: PRK13664 1033813007633 putative hydrolase; Provisional; Region: PRK11460 1033813007634 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1033813007635 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1033813007636 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 1033813007637 Helicase; Region: Helicase_RecD; pfam05127 1033813007638 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1033813007639 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1033813007640 Predicted metalloprotease [General function prediction only]; Region: COG2321 1033813007641 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1033813007642 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1033813007643 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1033813007644 ATP binding site [chemical binding]; other site 1033813007645 active site 1033813007646 substrate binding site [chemical binding]; other site 1033813007647 lipoprotein; Provisional; Region: PRK11679 1033813007648 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1033813007649 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1033813007650 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1033813007651 dimer interface [polypeptide binding]; other site 1033813007652 active site 1033813007653 catalytic residue [active] 1033813007654 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1033813007655 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1033813007656 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1033813007657 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1033813007658 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1033813007659 catalytic triad [active] 1033813007660 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1033813007661 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1033813007662 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1033813007663 Peptidase family M48; Region: Peptidase_M48; cl12018 1033813007664 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1033813007665 ArsC family; Region: ArsC; pfam03960 1033813007666 catalytic residues [active] 1033813007667 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1033813007668 DNA replication initiation factor; Provisional; Region: PRK08084 1033813007669 uracil transporter; Provisional; Region: PRK10720 1033813007670 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033813007671 active site 1033813007672 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1033813007673 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1033813007674 dimerization interface [polypeptide binding]; other site 1033813007675 putative ATP binding site [chemical binding]; other site 1033813007676 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1033813007677 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1033813007678 active site 1033813007679 substrate binding site [chemical binding]; other site 1033813007680 cosubstrate binding site; other site 1033813007681 catalytic site [active] 1033813007682 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1033813007683 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1033813007684 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1033813007685 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 1033813007686 domain interface [polypeptide binding]; other site 1033813007687 active site 1033813007688 catalytic site [active] 1033813007689 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1033813007690 putative active site [active] 1033813007691 catalytic site [active] 1033813007692 exopolyphosphatase; Provisional; Region: PRK10854 1033813007693 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1033813007694 MASE1; Region: MASE1; pfam05231 1033813007695 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1033813007696 diguanylate cyclase; Region: GGDEF; smart00267 1033813007697 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813007698 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1033813007699 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1033813007700 GMP synthase; Reviewed; Region: guaA; PRK00074 1033813007701 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1033813007702 AMP/PPi binding site [chemical binding]; other site 1033813007703 candidate oxyanion hole; other site 1033813007704 catalytic triad [active] 1033813007705 potential glutamine specificity residues [chemical binding]; other site 1033813007706 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1033813007707 ATP Binding subdomain [chemical binding]; other site 1033813007708 Ligand Binding sites [chemical binding]; other site 1033813007709 Dimerization subdomain; other site 1033813007710 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1033813007711 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1033813007712 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1033813007713 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1033813007714 active site 1033813007715 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1033813007716 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1033813007717 generic binding surface II; other site 1033813007718 generic binding surface I; other site 1033813007719 RatA-like protein; Provisional; Region: PRK15316 1033813007720 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1033813007721 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1033813007722 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1033813007723 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1033813007724 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1033813007725 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1033813007726 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1033813007727 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1033813007728 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1033813007729 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1033813007730 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1033813007731 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1033813007732 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1033813007733 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1033813007734 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1033813007735 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1033813007736 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1033813007737 intimin-like protein SinH; Provisional; Region: PRK15318 1033813007738 intimin-like protein SinH; Provisional; Region: PRK15318 1033813007739 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1033813007740 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1033813007741 GTP-binding protein Der; Reviewed; Region: PRK00093 1033813007742 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1033813007743 G1 box; other site 1033813007744 GTP/Mg2+ binding site [chemical binding]; other site 1033813007745 Switch I region; other site 1033813007746 G2 box; other site 1033813007747 Switch II region; other site 1033813007748 G3 box; other site 1033813007749 G4 box; other site 1033813007750 G5 box; other site 1033813007751 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1033813007752 G1 box; other site 1033813007753 GTP/Mg2+ binding site [chemical binding]; other site 1033813007754 Switch I region; other site 1033813007755 G2 box; other site 1033813007756 G3 box; other site 1033813007757 Switch II region; other site 1033813007758 G4 box; other site 1033813007759 G5 box; other site 1033813007760 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1033813007761 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1033813007762 Trp docking motif [polypeptide binding]; other site 1033813007763 active site 1033813007764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1033813007765 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1033813007766 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1033813007767 dimer interface [polypeptide binding]; other site 1033813007768 motif 1; other site 1033813007769 active site 1033813007770 motif 2; other site 1033813007771 motif 3; other site 1033813007772 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1033813007773 anticodon binding site; other site 1033813007774 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1033813007775 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1033813007776 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1033813007777 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1033813007778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813007779 non-specific DNA binding site [nucleotide binding]; other site 1033813007780 salt bridge; other site 1033813007781 sequence-specific DNA binding site [nucleotide binding]; other site 1033813007782 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1033813007783 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1033813007784 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813007785 FeS/SAM binding site; other site 1033813007786 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1033813007787 active site 1033813007788 multimer interface [polypeptide binding]; other site 1033813007789 penicillin-binding protein 1C; Provisional; Region: PRK11240 1033813007790 Transglycosylase; Region: Transgly; pfam00912 1033813007791 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1033813007792 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1033813007793 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1033813007794 MG2 domain; Region: A2M_N; pfam01835 1033813007795 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1033813007796 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1033813007797 surface patch; other site 1033813007798 thioester region; other site 1033813007799 specificity defining residues; other site 1033813007800 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1033813007801 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1033813007802 active site residue [active] 1033813007803 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1033813007804 active site residue [active] 1033813007805 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1033813007806 aminopeptidase B; Provisional; Region: PRK05015 1033813007807 Peptidase; Region: DUF3663; pfam12404 1033813007808 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1033813007809 interface (dimer of trimers) [polypeptide binding]; other site 1033813007810 Substrate-binding/catalytic site; other site 1033813007811 Zn-binding sites [ion binding]; other site 1033813007812 hypothetical protein; Provisional; Region: PRK10721 1033813007813 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1033813007814 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1033813007815 catalytic loop [active] 1033813007816 iron binding site [ion binding]; other site 1033813007817 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1033813007818 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1033813007819 nucleotide binding site [chemical binding]; other site 1033813007820 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1033813007821 SBD interface [polypeptide binding]; other site 1033813007822 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1033813007823 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1033813007824 HSP70 interaction site [polypeptide binding]; other site 1033813007825 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1033813007826 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1033813007827 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1033813007828 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1033813007829 trimerization site [polypeptide binding]; other site 1033813007830 active site 1033813007831 cysteine desulfurase; Provisional; Region: PRK14012 1033813007832 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1033813007833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1033813007834 catalytic residue [active] 1033813007835 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1033813007836 Rrf2 family protein; Region: rrf2_super; TIGR00738 1033813007837 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1033813007838 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1033813007839 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1033813007840 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1033813007841 active site 1033813007842 dimerization interface [polypeptide binding]; other site 1033813007843 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1033813007844 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1033813007845 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1033813007846 PRD domain; Region: PRD; pfam00874 1033813007847 PRD domain; Region: PRD; pfam00874 1033813007848 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1033813007849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813007850 putative substrate translocation pore; other site 1033813007851 Predicted membrane protein [Function unknown]; Region: COG2259 1033813007852 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1033813007853 active site 1033813007854 catalytic residues [active] 1033813007855 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1033813007856 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 1033813007857 putative NAD(P) binding site [chemical binding]; other site 1033813007858 catalytic Zn binding site [ion binding]; other site 1033813007859 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033813007860 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1033813007861 TM-ABC transporter signature motif; other site 1033813007862 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1033813007863 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1033813007864 Walker A/P-loop; other site 1033813007865 ATP binding site [chemical binding]; other site 1033813007866 Q-loop/lid; other site 1033813007867 ABC transporter signature motif; other site 1033813007868 Walker B; other site 1033813007869 D-loop; other site 1033813007870 H-loop/switch region; other site 1033813007871 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1033813007872 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1033813007873 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1033813007874 ligand binding site [chemical binding]; other site 1033813007875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1033813007876 TPR motif; other site 1033813007877 binding surface 1033813007878 TPR repeat; Region: TPR_11; pfam13414 1033813007879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1033813007880 TPR motif; other site 1033813007881 binding surface 1033813007882 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1033813007883 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1033813007884 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033813007885 nucleotide binding site [chemical binding]; other site 1033813007886 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1033813007887 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1033813007888 dimer interface [polypeptide binding]; other site 1033813007889 active site 1033813007890 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1033813007891 folate binding site [chemical binding]; other site 1033813007892 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1033813007893 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1033813007894 heme-binding site [chemical binding]; other site 1033813007895 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1033813007896 FAD binding pocket [chemical binding]; other site 1033813007897 FAD binding motif [chemical binding]; other site 1033813007898 phosphate binding motif [ion binding]; other site 1033813007899 beta-alpha-beta structure motif; other site 1033813007900 NAD binding pocket [chemical binding]; other site 1033813007901 Heme binding pocket [chemical binding]; other site 1033813007902 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1033813007903 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1033813007904 response regulator GlrR; Provisional; Region: PRK15115 1033813007905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813007906 active site 1033813007907 phosphorylation site [posttranslational modification] 1033813007908 intermolecular recognition site; other site 1033813007909 dimerization interface [polypeptide binding]; other site 1033813007910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813007911 Walker A motif; other site 1033813007912 ATP binding site [chemical binding]; other site 1033813007913 Walker B motif; other site 1033813007914 arginine finger; other site 1033813007915 hypothetical protein; Provisional; Region: PRK10722 1033813007916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1033813007917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813007918 dimer interface [polypeptide binding]; other site 1033813007919 phosphorylation site [posttranslational modification] 1033813007920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813007921 ATP binding site [chemical binding]; other site 1033813007922 Mg2+ binding site [ion binding]; other site 1033813007923 G-X-G motif; other site 1033813007924 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1033813007925 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1033813007926 dimerization interface [polypeptide binding]; other site 1033813007927 ATP binding site [chemical binding]; other site 1033813007928 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1033813007929 dimerization interface [polypeptide binding]; other site 1033813007930 ATP binding site [chemical binding]; other site 1033813007931 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1033813007932 putative active site [active] 1033813007933 catalytic triad [active] 1033813007934 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1033813007935 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813007936 substrate binding pocket [chemical binding]; other site 1033813007937 membrane-bound complex binding site; other site 1033813007938 hinge residues; other site 1033813007939 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1033813007940 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1033813007941 catalytic residue [active] 1033813007942 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1033813007943 nucleoside/Zn binding site; other site 1033813007944 dimer interface [polypeptide binding]; other site 1033813007945 catalytic motif [active] 1033813007946 hypothetical protein; Provisional; Region: PRK11590 1033813007947 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1033813007948 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1033813007949 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1033813007950 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1033813007951 putative active site [active] 1033813007952 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1033813007953 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 1033813007954 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1033813007955 active site 1033813007956 hydrophilic channel; other site 1033813007957 dimerization interface [polypeptide binding]; other site 1033813007958 catalytic residues [active] 1033813007959 active site lid [active] 1033813007960 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1033813007961 Recombination protein O N terminal; Region: RecO_N; pfam11967 1033813007962 Recombination protein O C terminal; Region: RecO_C; pfam02565 1033813007963 GTPase Era; Reviewed; Region: era; PRK00089 1033813007964 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1033813007965 G1 box; other site 1033813007966 GTP/Mg2+ binding site [chemical binding]; other site 1033813007967 Switch I region; other site 1033813007968 G2 box; other site 1033813007969 Switch II region; other site 1033813007970 G3 box; other site 1033813007971 G4 box; other site 1033813007972 G5 box; other site 1033813007973 KH domain; Region: KH_2; pfam07650 1033813007974 ribonuclease III; Reviewed; Region: rnc; PRK00102 1033813007975 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1033813007976 dimerization interface [polypeptide binding]; other site 1033813007977 active site 1033813007978 metal binding site [ion binding]; metal-binding site 1033813007979 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1033813007980 dsRNA binding site [nucleotide binding]; other site 1033813007981 signal peptidase I; Provisional; Region: PRK10861 1033813007982 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1033813007983 Catalytic site [active] 1033813007984 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1033813007985 GTP-binding protein LepA; Provisional; Region: PRK05433 1033813007986 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1033813007987 G1 box; other site 1033813007988 putative GEF interaction site [polypeptide binding]; other site 1033813007989 GTP/Mg2+ binding site [chemical binding]; other site 1033813007990 Switch I region; other site 1033813007991 G2 box; other site 1033813007992 G3 box; other site 1033813007993 Switch II region; other site 1033813007994 G4 box; other site 1033813007995 G5 box; other site 1033813007996 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1033813007997 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1033813007998 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1033813007999 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1033813008000 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1033813008001 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1033813008002 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1033813008003 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1033813008004 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1033813008005 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1033813008006 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1033813008007 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1033813008008 DNA binding residues [nucleotide binding] 1033813008009 L-aspartate oxidase; Provisional; Region: PRK09077 1033813008010 L-aspartate oxidase; Provisional; Region: PRK06175 1033813008011 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1033813008012 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1033813008013 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1033813008014 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1033813008015 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1033813008016 ATP binding site [chemical binding]; other site 1033813008017 Mg++ binding site [ion binding]; other site 1033813008018 motif III; other site 1033813008019 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813008020 nucleotide binding region [chemical binding]; other site 1033813008021 ATP-binding site [chemical binding]; other site 1033813008022 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033813008023 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813008024 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1033813008025 dimerization interface [polypeptide binding]; other site 1033813008026 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 1033813008027 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1033813008028 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1033813008029 ligand binding site [chemical binding]; other site 1033813008030 active site 1033813008031 UGI interface [polypeptide binding]; other site 1033813008032 catalytic site [active] 1033813008033 putative methyltransferase; Provisional; Region: PRK10864 1033813008034 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1033813008035 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1033813008036 thioredoxin 2; Provisional; Region: PRK10996 1033813008037 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1033813008038 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1033813008039 catalytic residues [active] 1033813008040 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1033813008041 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1033813008042 CoA binding domain; Region: CoA_binding_2; pfam13380 1033813008043 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1033813008044 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1033813008045 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1033813008046 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1033813008047 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1033813008048 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1033813008049 domain interface [polypeptide binding]; other site 1033813008050 putative active site [active] 1033813008051 catalytic site [active] 1033813008052 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1033813008053 domain interface [polypeptide binding]; other site 1033813008054 putative active site [active] 1033813008055 catalytic site [active] 1033813008056 lipoprotein; Provisional; Region: PRK10759 1033813008057 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1033813008058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813008059 putative substrate translocation pore; other site 1033813008060 protein disaggregation chaperone; Provisional; Region: PRK10865 1033813008061 Clp amino terminal domain; Region: Clp_N; pfam02861 1033813008062 Clp amino terminal domain; Region: Clp_N; pfam02861 1033813008063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813008064 Walker A motif; other site 1033813008065 ATP binding site [chemical binding]; other site 1033813008066 Walker B motif; other site 1033813008067 arginine finger; other site 1033813008068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813008069 Walker A motif; other site 1033813008070 ATP binding site [chemical binding]; other site 1033813008071 Walker B motif; other site 1033813008072 arginine finger; other site 1033813008073 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1033813008074 hypothetical protein; Provisional; Region: PRK10723 1033813008075 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1033813008076 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1033813008077 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033813008078 RNA binding surface [nucleotide binding]; other site 1033813008079 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1033813008080 active site 1033813008081 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1033813008082 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1033813008083 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1033813008084 30S subunit binding site; other site 1033813008085 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1033813008086 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1033813008087 Prephenate dehydratase; Region: PDT; pfam00800 1033813008088 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1033813008089 putative L-Phe binding site [chemical binding]; other site 1033813008090 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1033813008091 Chorismate mutase type II; Region: CM_2; cl00693 1033813008092 prephenate dehydrogenase; Validated; Region: PRK08507 1033813008093 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1033813008094 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1033813008095 lipoprotein; Provisional; Region: PRK11443 1033813008096 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 1033813008097 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1033813008098 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1033813008099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813008100 metal binding site [ion binding]; metal-binding site 1033813008101 active site 1033813008102 I-site; other site 1033813008103 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1033813008104 ligand binding site [chemical binding]; other site 1033813008105 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1033813008106 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1033813008107 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1033813008108 RimM N-terminal domain; Region: RimM; pfam01782 1033813008109 PRC-barrel domain; Region: PRC; pfam05239 1033813008110 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1033813008111 signal recognition particle protein; Provisional; Region: PRK10867 1033813008112 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1033813008113 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1033813008114 P loop; other site 1033813008115 GTP binding site [chemical binding]; other site 1033813008116 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1033813008117 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1033813008118 hypothetical protein; Provisional; Region: PRK11573 1033813008119 Domain of unknown function DUF21; Region: DUF21; pfam01595 1033813008120 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1033813008121 Transporter associated domain; Region: CorC_HlyC; smart01091 1033813008122 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1033813008123 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1033813008124 dimer interface [polypeptide binding]; other site 1033813008125 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1033813008126 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1033813008127 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1033813008128 recombination and repair protein; Provisional; Region: PRK10869 1033813008129 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1033813008130 Walker A/P-loop; other site 1033813008131 ATP binding site [chemical binding]; other site 1033813008132 Q-loop/lid; other site 1033813008133 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1033813008134 Q-loop/lid; other site 1033813008135 ABC transporter signature motif; other site 1033813008136 Walker B; other site 1033813008137 D-loop; other site 1033813008138 H-loop/switch region; other site 1033813008139 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1033813008140 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1033813008141 hypothetical protein; Validated; Region: PRK01777 1033813008142 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1033813008143 putative coenzyme Q binding site [chemical binding]; other site 1033813008144 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1033813008145 SmpB-tmRNA interface; other site 1033813008146 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1033813008147 substrate binding pocket [chemical binding]; other site 1033813008148 active site 1033813008149 iron coordination sites [ion binding]; other site 1033813008150 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1033813008151 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1033813008152 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1033813008153 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1033813008154 tetramerization interface [polypeptide binding]; other site 1033813008155 NAD(P) binding site [chemical binding]; other site 1033813008156 catalytic residues [active] 1033813008157 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1033813008158 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1033813008159 inhibitor-cofactor binding pocket; inhibition site 1033813008160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813008161 catalytic residue [active] 1033813008162 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 1033813008163 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1033813008164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813008165 DNA-binding site [nucleotide binding]; DNA binding site 1033813008166 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1033813008167 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1033813008168 bacterial OsmY and nodulation domain; Region: BON; smart00749 1033813008169 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1033813008170 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1033813008171 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1033813008172 dimerization interface [polypeptide binding]; other site 1033813008173 putative DNA binding site [nucleotide binding]; other site 1033813008174 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1033813008175 putative Zn2+ binding site [ion binding]; other site 1033813008176 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 1033813008177 active site residue [active] 1033813008178 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1033813008179 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1033813008180 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1033813008181 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1033813008182 hypothetical protein; Provisional; Region: PRK10556 1033813008183 hypothetical protein; Provisional; Region: PRK10132 1033813008184 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1033813008185 catalytic residues [active] 1033813008186 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1033813008187 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1033813008188 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1033813008189 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1033813008190 active site 1033813008191 dimer interface [polypeptide binding]; other site 1033813008192 catalytic residues [active] 1033813008193 effector binding site; other site 1033813008194 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1033813008195 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1033813008196 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1033813008197 dimer interface [polypeptide binding]; other site 1033813008198 putative radical transfer pathway; other site 1033813008199 diiron center [ion binding]; other site 1033813008200 tyrosyl radical; other site 1033813008201 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1033813008202 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1033813008203 Walker A/P-loop; other site 1033813008204 ATP binding site [chemical binding]; other site 1033813008205 Q-loop/lid; other site 1033813008206 ABC transporter signature motif; other site 1033813008207 Walker B; other site 1033813008208 D-loop; other site 1033813008209 H-loop/switch region; other site 1033813008210 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1033813008211 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1033813008212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813008213 dimer interface [polypeptide binding]; other site 1033813008214 conserved gate region; other site 1033813008215 putative PBP binding loops; other site 1033813008216 ABC-ATPase subunit interface; other site 1033813008217 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1033813008218 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1033813008219 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1033813008220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813008221 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1033813008222 putative L-valine exporter; Provisional; Region: PRK10408 1033813008223 transcriptional repressor MprA; Provisional; Region: PRK10870 1033813008224 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1033813008225 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1033813008226 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813008227 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813008228 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1033813008229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813008230 putative substrate translocation pore; other site 1033813008231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813008232 RNA ligase; Region: RNA_ligase; pfam09414 1033813008233 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1033813008234 Zn2+ binding site [ion binding]; other site 1033813008235 Mg2+ binding site [ion binding]; other site 1033813008236 AAA domain; Region: AAA_33; pfam13671 1033813008237 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1033813008238 glutamate--cysteine ligase; Provisional; Region: PRK02107 1033813008239 Predicted membrane protein [Function unknown]; Region: COG1238 1033813008240 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1033813008241 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813008242 motif II; other site 1033813008243 carbon storage regulator; Provisional; Region: PRK01712 1033813008244 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1033813008245 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1033813008246 motif 1; other site 1033813008247 active site 1033813008248 motif 2; other site 1033813008249 motif 3; other site 1033813008250 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1033813008251 DHHA1 domain; Region: DHHA1; pfam02272 1033813008252 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1033813008253 recombinase A; Provisional; Region: recA; PRK09354 1033813008254 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1033813008255 hexamer interface [polypeptide binding]; other site 1033813008256 Walker A motif; other site 1033813008257 ATP binding site [chemical binding]; other site 1033813008258 Walker B motif; other site 1033813008259 hypothetical protein; Validated; Region: PRK03661 1033813008260 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1033813008261 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1033813008262 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1033813008263 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 1033813008264 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1033813008265 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1033813008266 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1033813008267 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1033813008268 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1033813008269 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1033813008270 putative NAD(P) binding site [chemical binding]; other site 1033813008271 active site 1033813008272 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1033813008273 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1033813008274 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1033813008275 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813008276 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1033813008277 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1033813008278 putative active site [active] 1033813008279 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1033813008280 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1033813008281 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1033813008282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813008283 Walker A motif; other site 1033813008284 ATP binding site [chemical binding]; other site 1033813008285 Walker B motif; other site 1033813008286 arginine finger; other site 1033813008287 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1033813008288 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1033813008289 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1033813008290 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1033813008291 iron binding site [ion binding]; other site 1033813008292 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1033813008293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1033813008294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813008295 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1033813008296 Acylphosphatase; Region: Acylphosphatase; pfam00708 1033813008297 HypF finger; Region: zf-HYPF; pfam07503 1033813008298 HypF finger; Region: zf-HYPF; pfam07503 1033813008299 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1033813008300 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1033813008301 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1033813008302 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1033813008303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813008304 non-specific DNA binding site [nucleotide binding]; other site 1033813008305 salt bridge; other site 1033813008306 sequence-specific DNA binding site [nucleotide binding]; other site 1033813008307 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1033813008308 nickel binding site [ion binding]; other site 1033813008309 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1033813008310 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1033813008311 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1033813008312 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1033813008313 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1033813008314 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1033813008315 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1033813008316 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1033813008317 NADH dehydrogenase; Region: NADHdh; cl00469 1033813008318 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1033813008319 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1033813008320 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1033813008321 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1033813008322 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1033813008323 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1033813008324 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1033813008325 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1033813008326 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1033813008327 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1033813008328 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1033813008329 dimerization interface [polypeptide binding]; other site 1033813008330 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1033813008331 ATP binding site [chemical binding]; other site 1033813008332 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1033813008333 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1033813008334 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1033813008335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813008336 Walker A motif; other site 1033813008337 ATP binding site [chemical binding]; other site 1033813008338 Walker B motif; other site 1033813008339 arginine finger; other site 1033813008340 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1033813008341 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1033813008342 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1033813008343 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1033813008344 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1033813008345 MutS domain I; Region: MutS_I; pfam01624 1033813008346 MutS domain II; Region: MutS_II; pfam05188 1033813008347 MutS domain III; Region: MutS_III; pfam05192 1033813008348 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1033813008349 Walker A/P-loop; other site 1033813008350 ATP binding site [chemical binding]; other site 1033813008351 Q-loop/lid; other site 1033813008352 ABC transporter signature motif; other site 1033813008353 Walker B; other site 1033813008354 D-loop; other site 1033813008355 H-loop/switch region; other site 1033813008356 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1033813008357 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1033813008358 active site 1033813008359 metal binding site [ion binding]; metal-binding site 1033813008360 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1033813008361 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1033813008362 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813008363 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1033813008364 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1033813008365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1033813008366 putative aldolase; Validated; Region: PRK08130 1033813008367 active site 1033813008368 intersubunit interface [polypeptide binding]; other site 1033813008369 Zn2+ binding site [ion binding]; other site 1033813008370 hypothetical protein; Provisional; Region: PRK09989 1033813008371 putative transporter; Provisional; Region: PRK09821 1033813008372 GntP family permease; Region: GntP_permease; pfam02447 1033813008373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1033813008374 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1033813008375 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1033813008376 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1033813008377 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1033813008378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1033813008379 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1033813008380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1033813008381 DNA binding residues [nucleotide binding] 1033813008382 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1033813008383 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1033813008384 Peptidase family M23; Region: Peptidase_M23; pfam01551 1033813008385 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1033813008386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813008387 S-adenosylmethionine binding site [chemical binding]; other site 1033813008388 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1033813008389 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1033813008390 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1033813008391 Permutation of conserved domain; other site 1033813008392 active site 1033813008393 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1033813008394 homotrimer interaction site [polypeptide binding]; other site 1033813008395 zinc binding site [ion binding]; other site 1033813008396 CDP-binding sites; other site 1033813008397 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1033813008398 substrate binding site; other site 1033813008399 dimer interface; other site 1033813008400 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1033813008401 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1033813008402 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1033813008403 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1033813008404 ligand-binding site [chemical binding]; other site 1033813008405 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1033813008406 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1033813008407 CysD dimerization site [polypeptide binding]; other site 1033813008408 G1 box; other site 1033813008409 putative GEF interaction site [polypeptide binding]; other site 1033813008410 GTP/Mg2+ binding site [chemical binding]; other site 1033813008411 Switch I region; other site 1033813008412 G2 box; other site 1033813008413 G3 box; other site 1033813008414 Switch II region; other site 1033813008415 G4 box; other site 1033813008416 G5 box; other site 1033813008417 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1033813008418 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1033813008419 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1033813008420 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1033813008421 Active Sites [active] 1033813008422 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1033813008423 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1033813008424 metal binding site [ion binding]; metal-binding site 1033813008425 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1033813008426 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1033813008427 Active Sites [active] 1033813008428 sulfite reductase subunit beta; Provisional; Region: PRK13504 1033813008429 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1033813008430 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1033813008431 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1033813008432 Flavodoxin; Region: Flavodoxin_1; pfam00258 1033813008433 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1033813008434 FAD binding pocket [chemical binding]; other site 1033813008435 FAD binding motif [chemical binding]; other site 1033813008436 catalytic residues [active] 1033813008437 NAD binding pocket [chemical binding]; other site 1033813008438 phosphate binding motif [ion binding]; other site 1033813008439 beta-alpha-beta structure motif; other site 1033813008440 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1033813008441 active site 1033813008442 putative oxidoreductase FixC; Provisional; Region: PRK10157 1033813008443 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1033813008444 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1033813008445 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1033813008446 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1033813008447 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1033813008448 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1033813008449 Ligand binding site [chemical binding]; other site 1033813008450 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1033813008451 benzoate transport; Region: 2A0115; TIGR00895 1033813008452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813008453 putative substrate translocation pore; other site 1033813008454 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1033813008455 FAD binding domain; Region: FAD_binding_4; pfam01565 1033813008456 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1033813008457 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1033813008458 NADP binding site [chemical binding]; other site 1033813008459 homodimer interface [polypeptide binding]; other site 1033813008460 active site 1033813008461 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1033813008462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813008463 putative substrate translocation pore; other site 1033813008464 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1033813008465 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1033813008466 nucleotide binding site [chemical binding]; other site 1033813008467 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1033813008468 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1033813008469 putative ATP binding site [chemical binding]; other site 1033813008470 putative substrate binding site [chemical binding]; other site 1033813008471 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1033813008472 trimer interface; other site 1033813008473 sugar binding site [chemical binding]; other site 1033813008474 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1033813008475 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1033813008476 active site turn [active] 1033813008477 phosphorylation site [posttranslational modification] 1033813008478 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1033813008479 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1033813008480 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1033813008481 substrate binding [chemical binding]; other site 1033813008482 active site 1033813008483 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1033813008484 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1033813008485 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813008486 DNA binding site [nucleotide binding] 1033813008487 domain linker motif; other site 1033813008488 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1033813008489 dimerization interface [polypeptide binding]; other site 1033813008490 ligand binding site [chemical binding]; other site 1033813008491 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1033813008492 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1033813008493 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1033813008494 Repair protein; Region: Repair_PSII; pfam04536 1033813008495 enolase; Provisional; Region: eno; PRK00077 1033813008496 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1033813008497 dimer interface [polypeptide binding]; other site 1033813008498 metal binding site [ion binding]; metal-binding site 1033813008499 substrate binding pocket [chemical binding]; other site 1033813008500 CTP synthetase; Validated; Region: pyrG; PRK05380 1033813008501 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1033813008502 Catalytic site [active] 1033813008503 active site 1033813008504 UTP binding site [chemical binding]; other site 1033813008505 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1033813008506 active site 1033813008507 putative oxyanion hole; other site 1033813008508 catalytic triad [active] 1033813008509 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1033813008510 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1033813008511 homodimer interface [polypeptide binding]; other site 1033813008512 metal binding site [ion binding]; metal-binding site 1033813008513 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1033813008514 homodimer interface [polypeptide binding]; other site 1033813008515 active site 1033813008516 putative chemical substrate binding site [chemical binding]; other site 1033813008517 metal binding site [ion binding]; metal-binding site 1033813008518 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1033813008519 HD domain; Region: HD_4; pfam13328 1033813008520 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1033813008521 synthetase active site [active] 1033813008522 NTP binding site [chemical binding]; other site 1033813008523 metal binding site [ion binding]; metal-binding site 1033813008524 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1033813008525 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1033813008526 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1033813008527 TRAM domain; Region: TRAM; pfam01938 1033813008528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813008529 S-adenosylmethionine binding site [chemical binding]; other site 1033813008530 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1033813008531 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1033813008532 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033813008533 dimerization interface [polypeptide binding]; other site 1033813008534 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813008535 dimer interface [polypeptide binding]; other site 1033813008536 phosphorylation site [posttranslational modification] 1033813008537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813008538 ATP binding site [chemical binding]; other site 1033813008539 Mg2+ binding site [ion binding]; other site 1033813008540 G-X-G motif; other site 1033813008541 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1033813008542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813008543 active site 1033813008544 phosphorylation site [posttranslational modification] 1033813008545 intermolecular recognition site; other site 1033813008546 dimerization interface [polypeptide binding]; other site 1033813008547 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1033813008548 putative binding surface; other site 1033813008549 active site 1033813008550 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1033813008551 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1033813008552 active site 1033813008553 tetramer interface [polypeptide binding]; other site 1033813008554 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1033813008555 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1033813008556 active site 1033813008557 tetramer interface [polypeptide binding]; other site 1033813008558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813008559 D-galactonate transporter; Region: 2A0114; TIGR00893 1033813008560 putative substrate translocation pore; other site 1033813008561 flavodoxin; Provisional; Region: PRK08105 1033813008562 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1033813008563 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1033813008564 probable active site [active] 1033813008565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1033813008566 SecY interacting protein Syd; Provisional; Region: PRK04968 1033813008567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1033813008568 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1033813008569 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1033813008570 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1033813008571 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1033813008572 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1033813008573 serine transporter; Region: stp; TIGR00814 1033813008574 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1033813008575 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1033813008576 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1033813008577 flap endonuclease-like protein; Provisional; Region: PRK09482 1033813008578 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1033813008579 active site 1033813008580 metal binding site 1 [ion binding]; metal-binding site 1033813008581 putative 5' ssDNA interaction site; other site 1033813008582 metal binding site 3; metal-binding site 1033813008583 metal binding site 2 [ion binding]; metal-binding site 1033813008584 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1033813008585 putative DNA binding site [nucleotide binding]; other site 1033813008586 putative metal binding site [ion binding]; other site 1033813008587 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1033813008588 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1033813008589 dimer interface [polypeptide binding]; other site 1033813008590 active site 1033813008591 metal binding site [ion binding]; metal-binding site 1033813008592 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1033813008593 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1033813008594 intersubunit interface [polypeptide binding]; other site 1033813008595 active site 1033813008596 Zn2+ binding site [ion binding]; other site 1033813008597 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1033813008598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813008599 putative substrate translocation pore; other site 1033813008600 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1033813008601 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 1033813008602 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1033813008603 trimer interface [polypeptide binding]; other site 1033813008604 substrate binding site [chemical binding]; other site 1033813008605 Mn binding site [ion binding]; other site 1033813008606 L-fuculokinase; Provisional; Region: PRK10331 1033813008607 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1033813008608 nucleotide binding site [chemical binding]; other site 1033813008609 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 1033813008610 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1033813008611 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1033813008612 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813008613 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1033813008614 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1033813008615 hypothetical protein; Provisional; Region: PRK10873 1033813008616 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1033813008617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813008618 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1033813008619 dimerization interface [polypeptide binding]; other site 1033813008620 substrate binding pocket [chemical binding]; other site 1033813008621 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1033813008622 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1033813008623 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1033813008624 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1033813008625 catalytic residue [active] 1033813008626 CsdA-binding activator; Provisional; Region: PRK15019 1033813008627 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1033813008628 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1033813008629 putative ATP binding site [chemical binding]; other site 1033813008630 putative substrate interface [chemical binding]; other site 1033813008631 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1033813008632 MltA specific insert domain; Region: MltA; pfam03562 1033813008633 3D domain; Region: 3D; pfam06725 1033813008634 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1033813008635 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1033813008636 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1033813008637 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1033813008638 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1033813008639 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1033813008640 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1033813008641 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1033813008642 ligand binding site [chemical binding]; other site 1033813008643 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1033813008644 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1033813008645 Clp amino terminal domain; Region: Clp_N; pfam02861 1033813008646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813008647 Walker A motif; other site 1033813008648 ATP binding site [chemical binding]; other site 1033813008649 Walker B motif; other site 1033813008650 arginine finger; other site 1033813008651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813008652 Walker A motif; other site 1033813008653 ATP binding site [chemical binding]; other site 1033813008654 Walker B motif; other site 1033813008655 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1033813008656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1033813008657 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1033813008658 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1033813008659 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1033813008660 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1033813008661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 1033813008662 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1033813008663 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1033813008664 catalytic residue [active] 1033813008665 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1033813008666 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1033813008667 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1033813008668 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1033813008669 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1033813008670 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1033813008671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1033813008672 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1033813008673 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1033813008674 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1033813008675 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1033813008676 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1033813008677 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1033813008678 PAAR motif; Region: PAAR_motif; pfam05488 1033813008679 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1033813008680 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1033813008681 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1033813008682 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1033813008683 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1033813008684 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1033813008685 ImpA domain protein; Region: DUF3702; pfam12486 1033813008686 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 1033813008687 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1033813008688 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1033813008689 active site turn [active] 1033813008690 phosphorylation site [posttranslational modification] 1033813008691 AMIN domain; Region: AMIN; pfam11741 1033813008692 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1033813008693 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1033813008694 active site 1033813008695 metal binding site [ion binding]; metal-binding site 1033813008696 N-acetylglutamate synthase; Validated; Region: PRK05279 1033813008697 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1033813008698 putative feedback inhibition sensing region; other site 1033813008699 putative nucleotide binding site [chemical binding]; other site 1033813008700 putative substrate binding site [chemical binding]; other site 1033813008701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813008702 Coenzyme A binding pocket [chemical binding]; other site 1033813008703 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1033813008704 AAA domain; Region: AAA_30; pfam13604 1033813008705 Family description; Region: UvrD_C_2; pfam13538 1033813008706 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1033813008707 protease3; Provisional; Region: PRK15101 1033813008708 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1033813008709 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1033813008710 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1033813008711 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1033813008712 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1033813008713 hypothetical protein; Provisional; Region: PRK10332 1033813008714 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1033813008715 hypothetical protein; Provisional; Region: PRK11521 1033813008716 hypothetical protein; Provisional; Region: PRK10557 1033813008717 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1033813008718 hypothetical protein; Provisional; Region: PRK10506 1033813008719 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1033813008720 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1033813008721 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1033813008722 dimerization interface [polypeptide binding]; other site 1033813008723 active site 1033813008724 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 1033813008725 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1033813008726 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1033813008727 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1033813008728 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1033813008729 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1033813008730 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1033813008731 putative active site [active] 1033813008732 Ap4A binding site [chemical binding]; other site 1033813008733 nudix motif; other site 1033813008734 putative metal binding site [ion binding]; other site 1033813008735 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1033813008736 putative DNA-binding cleft [nucleotide binding]; other site 1033813008737 putative DNA clevage site; other site 1033813008738 molecular lever; other site 1033813008739 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1033813008740 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1033813008741 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033813008742 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033813008743 active site 1033813008744 catalytic tetrad [active] 1033813008745 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1033813008746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813008747 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1033813008748 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1033813008749 putative acyl-acceptor binding pocket; other site 1033813008750 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1033813008751 acyl-activating enzyme (AAE) consensus motif; other site 1033813008752 putative AMP binding site [chemical binding]; other site 1033813008753 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1033813008754 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813008755 DNA binding site [nucleotide binding] 1033813008756 domain linker motif; other site 1033813008757 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1033813008758 dimerization interface (closed form) [polypeptide binding]; other site 1033813008759 ligand binding site [chemical binding]; other site 1033813008760 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1033813008761 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1033813008762 active site 1033813008763 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1033813008764 substrate binding site [chemical binding]; other site 1033813008765 catalytic residues [active] 1033813008766 dimer interface [polypeptide binding]; other site 1033813008767 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1033813008768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813008769 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 1033813008770 putative dimerization interface [polypeptide binding]; other site 1033813008771 putative racemase; Provisional; Region: PRK10200 1033813008772 aspartate racemase; Region: asp_race; TIGR00035 1033813008773 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1033813008774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813008775 putative substrate translocation pore; other site 1033813008776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813008777 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1033813008778 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1033813008779 NADP binding site [chemical binding]; other site 1033813008780 homodimer interface [polypeptide binding]; other site 1033813008781 active site 1033813008782 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1033813008783 putative acyltransferase; Provisional; Region: PRK05790 1033813008784 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1033813008785 dimer interface [polypeptide binding]; other site 1033813008786 active site 1033813008787 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1033813008788 serine transporter; Region: stp; TIGR00814 1033813008789 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1033813008790 Peptidase family M23; Region: Peptidase_M23; pfam01551 1033813008791 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 1033813008792 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1033813008793 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1033813008794 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 1033813008795 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1033813008796 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 1033813008797 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1033813008798 catalytic loop [active] 1033813008799 iron binding site [ion binding]; other site 1033813008800 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1033813008801 GAF domain; Region: GAF; cl17456 1033813008802 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1033813008803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813008804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813008805 Walker A motif; other site 1033813008806 ATP binding site [chemical binding]; other site 1033813008807 Walker B motif; other site 1033813008808 arginine finger; other site 1033813008809 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1033813008810 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 1033813008811 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1033813008812 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1033813008813 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1033813008814 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1033813008815 catalytic residue [active] 1033813008816 peptidase; Reviewed; Region: PRK13004 1033813008817 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 1033813008818 putative metal binding site [ion binding]; other site 1033813008819 putative dimer interface [polypeptide binding]; other site 1033813008820 D-hydantoinase; Region: D-hydantoinase; TIGR02033 1033813008821 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1033813008822 tetramer interface [polypeptide binding]; other site 1033813008823 active site 1033813008824 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1033813008825 carbamate kinase; Reviewed; Region: PRK12686 1033813008826 putative substrate binding site [chemical binding]; other site 1033813008827 homodimer interface [polypeptide binding]; other site 1033813008828 nucleotide binding site [chemical binding]; other site 1033813008829 nucleotide binding site [chemical binding]; other site 1033813008830 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1033813008831 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1033813008832 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1033813008833 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 1033813008834 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1033813008835 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 1033813008836 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1033813008837 Ligand binding site; other site 1033813008838 metal-binding site 1033813008839 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 1033813008840 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1033813008841 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1033813008842 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 1033813008843 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1033813008844 active site 1033813008845 putative substrate binding pocket [chemical binding]; other site 1033813008846 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 1033813008847 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1033813008848 putative hypoxanthine oxidase; Provisional; Region: PRK09800 1033813008849 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1033813008850 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1033813008851 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1033813008852 uracil-xanthine permease; Region: ncs2; TIGR00801 1033813008853 guanine deaminase; Provisional; Region: PRK09228 1033813008854 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1033813008855 active site 1033813008856 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1033813008857 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1033813008858 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 1033813008859 4Fe-4S binding domain; Region: Fer4; pfam00037 1033813008860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1033813008861 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813008862 xanthine permease; Region: pbuX; TIGR03173 1033813008863 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1033813008864 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1033813008865 active site 1033813008866 metal binding site [ion binding]; metal-binding site 1033813008867 nudix motif; other site 1033813008868 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1033813008869 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1033813008870 dimer interface [polypeptide binding]; other site 1033813008871 putative anticodon binding site; other site 1033813008872 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1033813008873 motif 1; other site 1033813008874 active site 1033813008875 motif 2; other site 1033813008876 motif 3; other site 1033813008877 peptide chain release factor 2; Provisional; Region: PRK08787 1033813008878 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1033813008879 RF-1 domain; Region: RF-1; pfam00472 1033813008880 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1033813008881 DHH family; Region: DHH; pfam01368 1033813008882 DHHA1 domain; Region: DHHA1; pfam02272 1033813008883 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1033813008884 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1033813008885 dimerization domain [polypeptide binding]; other site 1033813008886 dimer interface [polypeptide binding]; other site 1033813008887 catalytic residues [active] 1033813008888 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1033813008889 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1033813008890 active site 1033813008891 Int/Topo IB signature motif; other site 1033813008892 flavodoxin FldB; Provisional; Region: PRK12359 1033813008893 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1033813008894 hypothetical protein; Provisional; Region: PRK10878 1033813008895 putative global regulator; Reviewed; Region: PRK09559 1033813008896 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1033813008897 hemolysin; Provisional; Region: PRK15087 1033813008898 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1033813008899 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1033813008900 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1033813008901 beta-galactosidase; Region: BGL; TIGR03356 1033813008902 glycine dehydrogenase; Provisional; Region: PRK05367 1033813008903 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1033813008904 tetramer interface [polypeptide binding]; other site 1033813008905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813008906 catalytic residue [active] 1033813008907 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1033813008908 tetramer interface [polypeptide binding]; other site 1033813008909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813008910 catalytic residue [active] 1033813008911 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1033813008912 lipoyl attachment site [posttranslational modification]; other site 1033813008913 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1033813008914 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1033813008915 oxidoreductase; Provisional; Region: PRK08013 1033813008916 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1033813008917 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1033813008918 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1033813008919 proline aminopeptidase P II; Provisional; Region: PRK10879 1033813008920 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1033813008921 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1033813008922 active site 1033813008923 hypothetical protein; Reviewed; Region: PRK01736 1033813008924 Z-ring-associated protein; Provisional; Region: PRK10972 1033813008925 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1033813008926 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1033813008927 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1033813008928 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1033813008929 ligand binding site [chemical binding]; other site 1033813008930 NAD binding site [chemical binding]; other site 1033813008931 tetramer interface [polypeptide binding]; other site 1033813008932 catalytic site [active] 1033813008933 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1033813008934 L-serine binding site [chemical binding]; other site 1033813008935 ACT domain interface; other site 1033813008936 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1033813008937 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1033813008938 active site 1033813008939 dimer interface [polypeptide binding]; other site 1033813008940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1033813008941 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1033813008942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813008943 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1033813008944 putative dimerization interface [polypeptide binding]; other site 1033813008945 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1033813008946 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1033813008947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813008948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033813008949 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1033813008950 oxidative stress defense protein; Provisional; Region: PRK11087 1033813008951 arginine exporter protein; Provisional; Region: PRK09304 1033813008952 mechanosensitive channel MscS; Provisional; Region: PRK10334 1033813008953 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1033813008954 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1033813008955 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1033813008956 active site 1033813008957 intersubunit interface [polypeptide binding]; other site 1033813008958 zinc binding site [ion binding]; other site 1033813008959 Na+ binding site [ion binding]; other site 1033813008960 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1033813008961 Phosphoglycerate kinase; Region: PGK; pfam00162 1033813008962 substrate binding site [chemical binding]; other site 1033813008963 hinge regions; other site 1033813008964 ADP binding site [chemical binding]; other site 1033813008965 catalytic site [active] 1033813008966 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1033813008967 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1033813008968 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1033813008969 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1033813008970 trimer interface [polypeptide binding]; other site 1033813008971 putative Zn binding site [ion binding]; other site 1033813008972 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1033813008973 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1033813008974 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1033813008975 Walker A/P-loop; other site 1033813008976 ATP binding site [chemical binding]; other site 1033813008977 Q-loop/lid; other site 1033813008978 ABC transporter signature motif; other site 1033813008979 Walker B; other site 1033813008980 D-loop; other site 1033813008981 H-loop/switch region; other site 1033813008982 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1033813008983 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1033813008984 Walker A/P-loop; other site 1033813008985 ATP binding site [chemical binding]; other site 1033813008986 Q-loop/lid; other site 1033813008987 ABC transporter signature motif; other site 1033813008988 Walker B; other site 1033813008989 D-loop; other site 1033813008990 H-loop/switch region; other site 1033813008991 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1033813008992 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1033813008993 active site 1033813008994 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1033813008995 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 1033813008996 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1033813008997 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1033813008998 putative active site [active] 1033813008999 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1033813009000 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1033813009001 putative NAD(P) binding site [chemical binding]; other site 1033813009002 catalytic Zn binding site [ion binding]; other site 1033813009003 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1033813009004 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1033813009005 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1033813009006 active site 1033813009007 P-loop; other site 1033813009008 phosphorylation site [posttranslational modification] 1033813009009 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033813009010 active site 1033813009011 phosphorylation site [posttranslational modification] 1033813009012 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1033813009013 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1033813009014 transketolase; Reviewed; Region: PRK12753 1033813009015 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1033813009016 TPP-binding site [chemical binding]; other site 1033813009017 dimer interface [polypeptide binding]; other site 1033813009018 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1033813009019 PYR/PP interface [polypeptide binding]; other site 1033813009020 dimer interface [polypeptide binding]; other site 1033813009021 TPP binding site [chemical binding]; other site 1033813009022 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1033813009023 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1033813009024 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1033813009025 agmatinase; Region: agmatinase; TIGR01230 1033813009026 oligomer interface [polypeptide binding]; other site 1033813009027 putative active site [active] 1033813009028 Mn binding site [ion binding]; other site 1033813009029 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1033813009030 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1033813009031 dimer interface [polypeptide binding]; other site 1033813009032 active site 1033813009033 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1033813009034 catalytic residues [active] 1033813009035 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1033813009036 Virulence promoting factor; Region: YqgB; pfam11036 1033813009037 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 1033813009038 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1033813009039 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1033813009040 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1033813009041 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1033813009042 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1033813009043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813009044 putative substrate translocation pore; other site 1033813009045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813009046 hypothetical protein; Provisional; Region: PRK04860 1033813009047 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1033813009048 DNA-specific endonuclease I; Provisional; Region: PRK15137 1033813009049 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1033813009050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1033813009051 RNA methyltransferase, RsmE family; Region: TIGR00046 1033813009052 glutathione synthetase; Provisional; Region: PRK05246 1033813009053 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1033813009054 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1033813009055 hypothetical protein; Validated; Region: PRK00228 1033813009056 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1033813009057 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1033813009058 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1033813009059 Walker A motif; other site 1033813009060 ATP binding site [chemical binding]; other site 1033813009061 Walker B motif; other site 1033813009062 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1033813009063 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1033813009064 catalytic residue [active] 1033813009065 YGGT family; Region: YGGT; pfam02325 1033813009066 YGGT family; Region: YGGT; pfam02325 1033813009067 hypothetical protein; Validated; Region: PRK05090 1033813009068 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1033813009069 active site 1033813009070 dimerization interface [polypeptide binding]; other site 1033813009071 HemN family oxidoreductase; Provisional; Region: PRK05660 1033813009072 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813009073 FeS/SAM binding site; other site 1033813009074 HemN C-terminal domain; Region: HemN_C; pfam06969 1033813009075 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1033813009076 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1033813009077 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1033813009078 DctM-like transporters; Region: DctM; pfam06808 1033813009079 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1033813009080 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1033813009081 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1033813009082 homodimer interface [polypeptide binding]; other site 1033813009083 active site 1033813009084 hypothetical protein; Provisional; Region: PRK10626 1033813009085 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1033813009086 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1033813009087 hypothetical protein; Provisional; Region: PRK11702 1033813009088 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1033813009089 adenine DNA glycosylase; Provisional; Region: PRK10880 1033813009090 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1033813009091 minor groove reading motif; other site 1033813009092 helix-hairpin-helix signature motif; other site 1033813009093 substrate binding pocket [chemical binding]; other site 1033813009094 active site 1033813009095 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1033813009096 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1033813009097 DNA binding and oxoG recognition site [nucleotide binding] 1033813009098 oxidative damage protection protein; Provisional; Region: PRK05408 1033813009099 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1033813009100 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1033813009101 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1033813009102 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1033813009103 catalytic residue [active] 1033813009104 nucleoside transporter; Region: 2A0110; TIGR00889 1033813009105 ornithine decarboxylase; Provisional; Region: PRK13578 1033813009106 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1033813009107 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1033813009108 homodimer interface [polypeptide binding]; other site 1033813009109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813009110 catalytic residue [active] 1033813009111 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1033813009112 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1033813009113 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1033813009114 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1033813009115 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 1033813009116 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1033813009117 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1033813009118 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1033813009119 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1033813009120 putative active site [active] 1033813009121 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1033813009122 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 1033813009123 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1033813009124 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1033813009125 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1033813009126 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1033813009127 Ligand binding site; other site 1033813009128 oligomer interface; other site 1033813009129 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 1033813009130 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1033813009131 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1033813009132 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1033813009133 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1033813009134 Walker A/P-loop; other site 1033813009135 ATP binding site [chemical binding]; other site 1033813009136 Q-loop/lid; other site 1033813009137 ABC transporter signature motif; other site 1033813009138 Walker B; other site 1033813009139 D-loop; other site 1033813009140 H-loop/switch region; other site 1033813009141 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1033813009142 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 1033813009143 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1033813009144 GspL-like protein; Provisional; Region: PRK09662 1033813009145 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1033813009146 type II secretion system protein J; Region: gspJ; TIGR01711 1033813009147 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1033813009148 type II secretion system protein I; Region: gspI; TIGR01707 1033813009149 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1033813009150 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 1033813009151 Type II transport protein GspH; Region: GspH; pfam12019 1033813009152 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1033813009153 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1033813009154 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1033813009155 type II secretion system protein F; Region: GspF; TIGR02120 1033813009156 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1033813009157 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1033813009158 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1033813009159 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1033813009160 Walker A motif; other site 1033813009161 ATP binding site [chemical binding]; other site 1033813009162 Walker B motif; other site 1033813009163 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1033813009164 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1033813009165 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1033813009166 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1033813009167 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1033813009168 putative type II secretion protein GspC; Provisional; Region: PRK09681 1033813009169 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1033813009170 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1033813009171 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1033813009172 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1033813009173 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1033813009174 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 1033813009175 Peptidase M60-like family; Region: M60-like; pfam13402 1033813009176 glycolate transporter; Provisional; Region: PRK09695 1033813009177 L-lactate permease; Region: Lactate_perm; cl00701 1033813009178 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1033813009179 active site 1033813009180 hypothetical protein; Provisional; Region: PRK09732 1033813009181 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1033813009182 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1033813009183 Cysteine-rich domain; Region: CCG; pfam02754 1033813009184 Cysteine-rich domain; Region: CCG; pfam02754 1033813009185 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1033813009186 FAD binding domain; Region: FAD_binding_4; pfam01565 1033813009187 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1033813009188 FAD binding domain; Region: FAD_binding_4; pfam01565 1033813009189 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1033813009190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813009191 DNA-binding site [nucleotide binding]; DNA binding site 1033813009192 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1033813009193 acyl-CoA synthetase; Validated; Region: PRK09192 1033813009194 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1033813009195 acyl-activating enzyme (AAE) consensus motif; other site 1033813009196 active site 1033813009197 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1033813009198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1033813009199 NAD(P) binding site [chemical binding]; other site 1033813009200 active site 1033813009201 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1033813009202 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1033813009203 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1033813009204 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1033813009205 catalytic residue [active] 1033813009206 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1033813009207 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1033813009208 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1033813009209 Predicted permeases [General function prediction only]; Region: COG0795 1033813009210 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 1033813009211 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1033813009212 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1033813009213 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1033813009214 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1033813009215 active site 1033813009216 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1033813009217 thymidylate kinase; Validated; Region: tmk; PRK00698 1033813009218 TMP-binding site; other site 1033813009219 ATP-binding site [chemical binding]; other site 1033813009220 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1033813009221 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1033813009222 TMP-binding site; other site 1033813009223 ATP-binding site [chemical binding]; other site 1033813009224 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1033813009225 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1033813009226 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1033813009227 CHAP domain; Region: CHAP; pfam05257 1033813009228 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1033813009229 putative S-transferase; Provisional; Region: PRK11752 1033813009230 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1033813009231 C-terminal domain interface [polypeptide binding]; other site 1033813009232 GSH binding site (G-site) [chemical binding]; other site 1033813009233 dimer interface [polypeptide binding]; other site 1033813009234 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1033813009235 dimer interface [polypeptide binding]; other site 1033813009236 N-terminal domain interface [polypeptide binding]; other site 1033813009237 active site 1033813009238 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1033813009239 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1033813009240 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 1033813009241 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 1033813009242 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1033813009243 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1033813009244 putative substrate-binding site; other site 1033813009245 nickel binding site [ion binding]; other site 1033813009246 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1033813009247 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1033813009248 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1033813009249 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1033813009250 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1033813009251 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1033813009252 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1033813009253 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1033813009254 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1033813009255 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1033813009256 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1033813009257 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1033813009258 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033813009259 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033813009260 active site 1033813009261 catalytic tetrad [active] 1033813009262 hypothetical protein; Provisional; Region: PRK05208 1033813009263 oxidoreductase; Provisional; Region: PRK07985 1033813009264 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1033813009265 NAD binding site [chemical binding]; other site 1033813009266 metal binding site [ion binding]; metal-binding site 1033813009267 active site 1033813009268 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1033813009269 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1033813009270 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1033813009271 cystathionine beta-lyase; Provisional; Region: PRK08114 1033813009272 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1033813009273 homodimer interface [polypeptide binding]; other site 1033813009274 substrate-cofactor binding pocket; other site 1033813009275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813009276 catalytic residue [active] 1033813009277 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1033813009278 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1033813009279 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1033813009280 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1033813009281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813009282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813009283 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1033813009284 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1033813009285 dimer interface [polypeptide binding]; other site 1033813009286 active site 1033813009287 metal binding site [ion binding]; metal-binding site 1033813009288 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033813009289 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033813009290 active site 1033813009291 catalytic tetrad [active] 1033813009292 putative outer membrane lipoprotein; Provisional; Region: PRK09973 1033813009293 hypothetical protein; Provisional; Region: PRK01254 1033813009294 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1033813009295 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1033813009296 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1033813009297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813009298 DNA-binding site [nucleotide binding]; DNA binding site 1033813009299 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1033813009300 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1033813009301 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1033813009302 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1033813009303 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1033813009304 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1033813009305 putative NAD(P) binding site [chemical binding]; other site 1033813009306 catalytic Zn binding site [ion binding]; other site 1033813009307 structural Zn binding site [ion binding]; other site 1033813009308 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1033813009309 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1033813009310 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1033813009311 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1033813009312 DctM-like transporters; Region: DctM; pfam06808 1033813009313 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1033813009314 FtsI repressor; Provisional; Region: PRK10883 1033813009315 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1033813009316 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1033813009317 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1033813009318 putative acyl-acceptor binding pocket; other site 1033813009319 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 1033813009320 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1033813009321 CAP-like domain; other site 1033813009322 active site 1033813009323 primary dimer interface [polypeptide binding]; other site 1033813009324 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033813009325 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 1033813009326 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1033813009327 peptide binding site [polypeptide binding]; other site 1033813009328 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1033813009329 TIGR00156 family protein; Region: TIGR00156 1033813009330 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1033813009331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813009332 active site 1033813009333 phosphorylation site [posttranslational modification] 1033813009334 intermolecular recognition site; other site 1033813009335 dimerization interface [polypeptide binding]; other site 1033813009336 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813009337 DNA binding site [nucleotide binding] 1033813009338 sensor protein QseC; Provisional; Region: PRK10337 1033813009339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813009340 dimer interface [polypeptide binding]; other site 1033813009341 phosphorylation site [posttranslational modification] 1033813009342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813009343 ATP binding site [chemical binding]; other site 1033813009344 Mg2+ binding site [ion binding]; other site 1033813009345 G-X-G motif; other site 1033813009346 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1033813009347 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1033813009348 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1033813009349 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1033813009350 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 1033813009351 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1033813009352 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1033813009353 siderophore binding site; other site 1033813009354 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1033813009355 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813009356 ABC-ATPase subunit interface; other site 1033813009357 dimer interface [polypeptide binding]; other site 1033813009358 putative PBP binding regions; other site 1033813009359 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1033813009360 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813009361 dimer interface [polypeptide binding]; other site 1033813009362 putative PBP binding regions; other site 1033813009363 ABC-ATPase subunit interface; other site 1033813009364 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1033813009365 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1033813009366 Walker A/P-loop; other site 1033813009367 ATP binding site [chemical binding]; other site 1033813009368 Q-loop/lid; other site 1033813009369 ABC transporter signature motif; other site 1033813009370 Walker B; other site 1033813009371 D-loop; other site 1033813009372 H-loop/switch region; other site 1033813009373 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1033813009374 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813009375 N-terminal plug; other site 1033813009376 ligand-binding site [chemical binding]; other site 1033813009377 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1033813009378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813009379 ATP binding site [chemical binding]; other site 1033813009380 Mg2+ binding site [ion binding]; other site 1033813009381 G-X-G motif; other site 1033813009382 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1033813009383 anchoring element; other site 1033813009384 dimer interface [polypeptide binding]; other site 1033813009385 ATP binding site [chemical binding]; other site 1033813009386 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1033813009387 active site 1033813009388 metal binding site [ion binding]; metal-binding site 1033813009389 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1033813009390 esterase YqiA; Provisional; Region: PRK11071 1033813009391 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1033813009392 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1033813009393 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1033813009394 active site 1033813009395 metal binding site [ion binding]; metal-binding site 1033813009396 hexamer interface [polypeptide binding]; other site 1033813009397 putative dehydrogenase; Provisional; Region: PRK11039 1033813009398 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1033813009399 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1033813009400 dimer interface [polypeptide binding]; other site 1033813009401 ADP-ribose binding site [chemical binding]; other site 1033813009402 active site 1033813009403 nudix motif; other site 1033813009404 metal binding site [ion binding]; metal-binding site 1033813009405 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1033813009406 hypothetical protein; Provisional; Region: PRK11653 1033813009407 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1033813009408 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1033813009409 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1033813009410 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1033813009411 catalytic residues [active] 1033813009412 hinge region; other site 1033813009413 alpha helical domain; other site 1033813009414 putative disulfide oxidoreductase; Provisional; Region: PRK04307 1033813009415 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1033813009416 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1033813009417 putative active site [active] 1033813009418 metal binding site [ion binding]; metal-binding site 1033813009419 zinc transporter ZupT; Provisional; Region: PRK04201 1033813009420 ZIP Zinc transporter; Region: Zip; pfam02535 1033813009421 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 1033813009422 putative fimbrial protein; Provisional; Region: PRK09733 1033813009423 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1033813009424 PapC N-terminal domain; Region: PapC_N; pfam13954 1033813009425 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1033813009426 PapC C-terminal domain; Region: PapC_C; pfam13953 1033813009427 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1033813009428 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1033813009429 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1033813009430 Fimbrial protein; Region: Fimbrial; pfam00419 1033813009431 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1033813009432 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1033813009433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1033813009434 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 1033813009435 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 1033813009436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1033813009437 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1033813009438 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1033813009439 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1033813009440 putative ribose interaction site [chemical binding]; other site 1033813009441 putative ADP binding site [chemical binding]; other site 1033813009442 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1033813009443 active site 1033813009444 nucleotide binding site [chemical binding]; other site 1033813009445 HIGH motif; other site 1033813009446 KMSKS motif; other site 1033813009447 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1033813009448 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1033813009449 metal binding triad; other site 1033813009450 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1033813009451 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1033813009452 metal binding triad; other site 1033813009453 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1033813009454 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1033813009455 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1033813009456 putative active site [active] 1033813009457 putative metal binding residues [ion binding]; other site 1033813009458 signature motif; other site 1033813009459 putative triphosphate binding site [ion binding]; other site 1033813009460 CHAD domain; Region: CHAD; pfam05235 1033813009461 SH3 domain-containing protein; Provisional; Region: PRK10884 1033813009462 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1033813009463 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1033813009464 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1033813009465 active site 1033813009466 NTP binding site [chemical binding]; other site 1033813009467 metal binding triad [ion binding]; metal-binding site 1033813009468 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1033813009469 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1033813009470 Zn2+ binding site [ion binding]; other site 1033813009471 Mg2+ binding site [ion binding]; other site 1033813009472 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1033813009473 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1033813009474 homooctamer interface [polypeptide binding]; other site 1033813009475 active site 1033813009476 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1033813009477 transcriptional activator TtdR; Provisional; Region: PRK09801 1033813009478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813009479 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1033813009480 putative effector binding pocket; other site 1033813009481 putative dimerization interface [polypeptide binding]; other site 1033813009482 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1033813009483 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1033813009484 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1033813009485 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1033813009486 transmembrane helices; other site 1033813009487 UGMP family protein; Validated; Region: PRK09604 1033813009488 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1033813009489 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1033813009490 DNA primase; Validated; Region: dnaG; PRK05667 1033813009491 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1033813009492 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1033813009493 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1033813009494 active site 1033813009495 metal binding site [ion binding]; metal-binding site 1033813009496 interdomain interaction site; other site 1033813009497 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1033813009498 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1033813009499 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1033813009500 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1033813009501 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1033813009502 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1033813009503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1033813009504 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1033813009505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1033813009506 DNA binding residues [nucleotide binding] 1033813009507 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1033813009508 active site 1033813009509 SUMO-1 interface [polypeptide binding]; other site 1033813009510 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1033813009511 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1033813009512 FAD binding pocket [chemical binding]; other site 1033813009513 FAD binding motif [chemical binding]; other site 1033813009514 phosphate binding motif [ion binding]; other site 1033813009515 NAD binding pocket [chemical binding]; other site 1033813009516 Predicted transcriptional regulators [Transcription]; Region: COG1695 1033813009517 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1033813009518 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813009519 PAS fold; Region: PAS_3; pfam08447 1033813009520 putative active site [active] 1033813009521 heme pocket [chemical binding]; other site 1033813009522 HAMP domain; Region: HAMP; pfam00672 1033813009523 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1033813009524 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1033813009525 dimer interface [polypeptide binding]; other site 1033813009526 putative CheW interface [polypeptide binding]; other site 1033813009527 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1033813009528 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1033813009529 inhibitor-cofactor binding pocket; inhibition site 1033813009530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813009531 catalytic residue [active] 1033813009532 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1033813009533 dimer interface [polypeptide binding]; other site 1033813009534 putative tRNA-binding site [nucleotide binding]; other site 1033813009535 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1033813009536 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813009537 DNA binding site [nucleotide binding] 1033813009538 domain linker motif; other site 1033813009539 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1033813009540 putative dimerization interface [polypeptide binding]; other site 1033813009541 putative ligand binding site [chemical binding]; other site 1033813009542 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1033813009543 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1033813009544 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1033813009545 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1033813009546 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1033813009547 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 1033813009548 inner membrane transporter YjeM; Provisional; Region: PRK15238 1033813009549 alpha-glucosidase; Provisional; Region: PRK10137 1033813009550 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1033813009551 Trehalase; Region: Trehalase; cl17346 1033813009552 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1033813009553 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1033813009554 active site 1033813009555 FMN binding site [chemical binding]; other site 1033813009556 2,4-decadienoyl-CoA binding site; other site 1033813009557 catalytic residue [active] 1033813009558 4Fe-4S cluster binding site [ion binding]; other site 1033813009559 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1033813009560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813009561 non-specific DNA binding site [nucleotide binding]; other site 1033813009562 salt bridge; other site 1033813009563 sequence-specific DNA binding site [nucleotide binding]; other site 1033813009564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 1033813009565 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1033813009566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813009567 S-adenosylmethionine binding site [chemical binding]; other site 1033813009568 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1033813009569 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1033813009570 putative active site [active] 1033813009571 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1033813009572 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1033813009573 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1033813009574 serine/threonine transporter SstT; Provisional; Region: PRK13628 1033813009575 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1033813009576 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1033813009577 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1033813009578 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1033813009579 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1033813009580 Glucuronate isomerase; Region: UxaC; pfam02614 1033813009581 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1033813009582 D-galactonate transporter; Region: 2A0114; TIGR00893 1033813009583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813009584 putative substrate translocation pore; other site 1033813009585 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1033813009586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813009587 DNA-binding site [nucleotide binding]; DNA binding site 1033813009588 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1033813009589 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1033813009590 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1033813009591 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1033813009592 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1033813009593 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1033813009594 Predicted membrane protein [Function unknown]; Region: COG5393 1033813009595 YqjK-like protein; Region: YqjK; pfam13997 1033813009596 Predicted membrane protein [Function unknown]; Region: COG2259 1033813009597 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1033813009598 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1033813009599 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1033813009600 putative dimer interface [polypeptide binding]; other site 1033813009601 N-terminal domain interface [polypeptide binding]; other site 1033813009602 putative substrate binding pocket (H-site) [chemical binding]; other site 1033813009603 Predicted membrane protein [Function unknown]; Region: COG3152 1033813009604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813009605 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1033813009606 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1033813009607 dimerization interface [polypeptide binding]; other site 1033813009608 Pirin; Region: Pirin; pfam02678 1033813009609 Pirin-related protein [General function prediction only]; Region: COG1741 1033813009610 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1033813009611 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1033813009612 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1033813009613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1033813009614 Transposase; Region: HTH_Tnp_1; cl17663 1033813009615 putative transposase OrfB; Reviewed; Region: PHA02517 1033813009616 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 1033813009617 glycerate kinase I; Provisional; Region: PRK10342 1033813009618 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1033813009619 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1033813009620 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1033813009621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813009622 D-galactonate transporter; Region: 2A0114; TIGR00893 1033813009623 putative substrate translocation pore; other site 1033813009624 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1033813009625 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1033813009626 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1033813009627 putative regulator PrlF; Provisional; Region: PRK09974 1033813009628 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1033813009629 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 1033813009630 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 1033813009631 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1033813009632 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813009633 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 1033813009634 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1033813009635 active site 1033813009636 phosphorylation site [posttranslational modification] 1033813009637 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1033813009638 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1033813009639 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1033813009640 active pocket/dimerization site; other site 1033813009641 active site 1033813009642 phosphorylation site [posttranslational modification] 1033813009643 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1033813009644 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1033813009645 active site 1033813009646 dimer interface [polypeptide binding]; other site 1033813009647 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1033813009648 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1033813009649 dimer interface [polypeptide binding]; other site 1033813009650 active site 1033813009651 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1033813009652 putative active site [active] 1033813009653 tagatose-bisphosphate aldolase; Reviewed; Region: kbaY; PRK12738 1033813009654 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1033813009655 active site 1033813009656 intersubunit interface [polypeptide binding]; other site 1033813009657 zinc binding site [ion binding]; other site 1033813009658 Na+ binding site [ion binding]; other site 1033813009659 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1033813009660 active site 1033813009661 phosphorylation site [posttranslational modification] 1033813009662 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 1033813009663 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 1033813009664 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1033813009665 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1033813009666 active site 1033813009667 trimer interface [polypeptide binding]; other site 1033813009668 allosteric site; other site 1033813009669 active site lid [active] 1033813009670 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1033813009671 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1033813009672 putative SAM binding site [chemical binding]; other site 1033813009673 putative homodimer interface [polypeptide binding]; other site 1033813009674 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1033813009675 TIGR00252 family protein; Region: TIGR00252 1033813009676 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1033813009677 dimer interface [polypeptide binding]; other site 1033813009678 active site 1033813009679 outer membrane lipoprotein; Provisional; Region: PRK11023 1033813009680 BON domain; Region: BON; pfam04972 1033813009681 BON domain; Region: BON; pfam04972 1033813009682 Predicted permease; Region: DUF318; pfam03773 1033813009683 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1033813009684 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1033813009685 NAD binding site [chemical binding]; other site 1033813009686 active site 1033813009687 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1033813009688 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1033813009689 proposed catalytic triad [active] 1033813009690 conserved cys residue [active] 1033813009691 hypothetical protein; Provisional; Region: PRK03467 1033813009692 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1033813009693 putative active site [active] 1033813009694 GIY-YIG motif/motif A; other site 1033813009695 putative metal binding site [ion binding]; other site 1033813009696 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1033813009697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813009698 Coenzyme A binding pocket [chemical binding]; other site 1033813009699 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1033813009700 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1033813009701 Peptidase family U32; Region: Peptidase_U32; pfam01136 1033813009702 putative protease; Provisional; Region: PRK15447 1033813009703 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1033813009704 hypothetical protein; Provisional; Region: PRK10508 1033813009705 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1033813009706 tryptophan permease; Provisional; Region: PRK10483 1033813009707 aromatic amino acid transport protein; Region: araaP; TIGR00837 1033813009708 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 1033813009709 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1033813009710 ATP binding site [chemical binding]; other site 1033813009711 Mg++ binding site [ion binding]; other site 1033813009712 motif III; other site 1033813009713 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813009714 nucleotide binding region [chemical binding]; other site 1033813009715 ATP-binding site [chemical binding]; other site 1033813009716 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1033813009717 putative RNA binding site [nucleotide binding]; other site 1033813009718 lipoprotein NlpI; Provisional; Region: PRK11189 1033813009719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1033813009720 binding surface 1033813009721 TPR motif; other site 1033813009722 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1033813009723 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1033813009724 RNase E interface [polypeptide binding]; other site 1033813009725 trimer interface [polypeptide binding]; other site 1033813009726 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1033813009727 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1033813009728 RNase E interface [polypeptide binding]; other site 1033813009729 trimer interface [polypeptide binding]; other site 1033813009730 active site 1033813009731 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1033813009732 putative nucleic acid binding region [nucleotide binding]; other site 1033813009733 G-X-X-G motif; other site 1033813009734 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1033813009735 RNA binding site [nucleotide binding]; other site 1033813009736 domain interface; other site 1033813009737 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1033813009738 16S/18S rRNA binding site [nucleotide binding]; other site 1033813009739 S13e-L30e interaction site [polypeptide binding]; other site 1033813009740 25S rRNA binding site [nucleotide binding]; other site 1033813009741 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1033813009742 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1033813009743 RNA binding site [nucleotide binding]; other site 1033813009744 active site 1033813009745 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1033813009746 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1033813009747 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1033813009748 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1033813009749 translation initiation factor IF-2; Region: IF-2; TIGR00487 1033813009750 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1033813009751 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1033813009752 G1 box; other site 1033813009753 putative GEF interaction site [polypeptide binding]; other site 1033813009754 GTP/Mg2+ binding site [chemical binding]; other site 1033813009755 Switch I region; other site 1033813009756 G2 box; other site 1033813009757 G3 box; other site 1033813009758 Switch II region; other site 1033813009759 G4 box; other site 1033813009760 G5 box; other site 1033813009761 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1033813009762 Translation-initiation factor 2; Region: IF-2; pfam11987 1033813009763 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1033813009764 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1033813009765 NusA N-terminal domain; Region: NusA_N; pfam08529 1033813009766 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1033813009767 RNA binding site [nucleotide binding]; other site 1033813009768 homodimer interface [polypeptide binding]; other site 1033813009769 NusA-like KH domain; Region: KH_5; pfam13184 1033813009770 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1033813009771 G-X-X-G motif; other site 1033813009772 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1033813009773 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1033813009774 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1033813009775 hypothetical protein; Provisional; Region: PRK14641 1033813009776 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1033813009777 putative oligomer interface [polypeptide binding]; other site 1033813009778 putative RNA binding site [nucleotide binding]; other site 1033813009779 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1033813009780 ANP binding site [chemical binding]; other site 1033813009781 Substrate Binding Site II [chemical binding]; other site 1033813009782 Substrate Binding Site I [chemical binding]; other site 1033813009783 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1033813009784 Sulfatase; Region: Sulfatase; pfam00884 1033813009785 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1033813009786 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1033813009787 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1033813009788 active site 1033813009789 substrate binding site [chemical binding]; other site 1033813009790 metal binding site [ion binding]; metal-binding site 1033813009791 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1033813009792 dihydropteroate synthase; Region: DHPS; TIGR01496 1033813009793 substrate binding pocket [chemical binding]; other site 1033813009794 dimer interface [polypeptide binding]; other site 1033813009795 inhibitor binding site; inhibition site 1033813009796 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1033813009797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813009798 Walker A motif; other site 1033813009799 ATP binding site [chemical binding]; other site 1033813009800 Walker B motif; other site 1033813009801 arginine finger; other site 1033813009802 Peptidase family M41; Region: Peptidase_M41; pfam01434 1033813009803 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1033813009804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813009805 S-adenosylmethionine binding site [chemical binding]; other site 1033813009806 RNA-binding protein YhbY; Provisional; Region: PRK10343 1033813009807 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1033813009808 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1033813009809 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1033813009810 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1033813009811 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1033813009812 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1033813009813 GTP1/OBG; Region: GTP1_OBG; pfam01018 1033813009814 Obg GTPase; Region: Obg; cd01898 1033813009815 G1 box; other site 1033813009816 GTP/Mg2+ binding site [chemical binding]; other site 1033813009817 Switch I region; other site 1033813009818 G2 box; other site 1033813009819 G3 box; other site 1033813009820 Switch II region; other site 1033813009821 G4 box; other site 1033813009822 G5 box; other site 1033813009823 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1033813009824 EamA-like transporter family; Region: EamA; pfam00892 1033813009825 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1033813009826 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1033813009827 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1033813009828 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1033813009829 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1033813009830 substrate binding pocket [chemical binding]; other site 1033813009831 chain length determination region; other site 1033813009832 substrate-Mg2+ binding site; other site 1033813009833 catalytic residues [active] 1033813009834 aspartate-rich region 1; other site 1033813009835 active site lid residues [active] 1033813009836 aspartate-rich region 2; other site 1033813009837 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1033813009838 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1033813009839 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1033813009840 hinge; other site 1033813009841 active site 1033813009842 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1033813009843 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1033813009844 anti sigma factor interaction site; other site 1033813009845 regulatory phosphorylation site [posttranslational modification]; other site 1033813009846 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1033813009847 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1033813009848 mce related protein; Region: MCE; pfam02470 1033813009849 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1033813009850 conserved hypothetical integral membrane protein; Region: TIGR00056 1033813009851 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1033813009852 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1033813009853 Walker A/P-loop; other site 1033813009854 ATP binding site [chemical binding]; other site 1033813009855 Q-loop/lid; other site 1033813009856 ABC transporter signature motif; other site 1033813009857 Walker B; other site 1033813009858 D-loop; other site 1033813009859 H-loop/switch region; other site 1033813009860 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1033813009861 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1033813009862 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1033813009863 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1033813009864 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1033813009865 putative active site [active] 1033813009866 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1033813009867 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1033813009868 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1033813009869 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1033813009870 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1033813009871 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1033813009872 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1033813009873 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1033813009874 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1033813009875 Walker A/P-loop; other site 1033813009876 ATP binding site [chemical binding]; other site 1033813009877 Q-loop/lid; other site 1033813009878 ABC transporter signature motif; other site 1033813009879 Walker B; other site 1033813009880 D-loop; other site 1033813009881 H-loop/switch region; other site 1033813009882 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1033813009883 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1033813009884 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1033813009885 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1033813009886 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1033813009887 30S subunit binding site; other site 1033813009888 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033813009889 active site 1033813009890 phosphorylation site [posttranslational modification] 1033813009891 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1033813009892 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1033813009893 dimerization domain swap beta strand [polypeptide binding]; other site 1033813009894 regulatory protein interface [polypeptide binding]; other site 1033813009895 active site 1033813009896 regulatory phosphorylation site [posttranslational modification]; other site 1033813009897 hypothetical protein; Provisional; Region: PRK10345 1033813009898 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1033813009899 Transglycosylase; Region: Transgly; cl17702 1033813009900 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1033813009901 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1033813009902 conserved cys residue [active] 1033813009903 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1033813009904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813009905 putative active site [active] 1033813009906 heme pocket [chemical binding]; other site 1033813009907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813009908 dimer interface [polypeptide binding]; other site 1033813009909 phosphorylation site [posttranslational modification] 1033813009910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813009911 ATP binding site [chemical binding]; other site 1033813009912 Mg2+ binding site [ion binding]; other site 1033813009913 G-X-G motif; other site 1033813009914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813009915 active site 1033813009916 phosphorylation site [posttranslational modification] 1033813009917 intermolecular recognition site; other site 1033813009918 dimerization interface [polypeptide binding]; other site 1033813009919 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1033813009920 putative binding surface; other site 1033813009921 active site 1033813009922 radical SAM protein, TIGR01212 family; Region: TIGR01212 1033813009923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813009924 FeS/SAM binding site; other site 1033813009925 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1033813009926 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1033813009927 active site 1033813009928 dimer interface [polypeptide binding]; other site 1033813009929 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1033813009930 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1033813009931 active site 1033813009932 FMN binding site [chemical binding]; other site 1033813009933 substrate binding site [chemical binding]; other site 1033813009934 3Fe-4S cluster binding site [ion binding]; other site 1033813009935 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1033813009936 domain interface; other site 1033813009937 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1033813009938 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1033813009939 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813009940 Domain of unknown function (DUF386); Region: DUF386; cl01047 1033813009941 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1033813009942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033813009943 nucleotide binding site [chemical binding]; other site 1033813009944 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1033813009945 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1033813009946 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1033813009947 putative active site cavity [active] 1033813009948 putative sialic acid transporter; Provisional; Region: PRK03893 1033813009949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813009950 putative substrate translocation pore; other site 1033813009951 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1033813009952 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1033813009953 inhibitor site; inhibition site 1033813009954 active site 1033813009955 dimer interface [polypeptide binding]; other site 1033813009956 catalytic residue [active] 1033813009957 transcriptional regulator NanR; Provisional; Region: PRK03837 1033813009958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813009959 DNA-binding site [nucleotide binding]; DNA binding site 1033813009960 FCD domain; Region: FCD; pfam07729 1033813009961 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 1033813009962 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1033813009963 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1033813009964 C-terminal domain interface [polypeptide binding]; other site 1033813009965 putative GSH binding site (G-site) [chemical binding]; other site 1033813009966 dimer interface [polypeptide binding]; other site 1033813009967 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1033813009968 dimer interface [polypeptide binding]; other site 1033813009969 N-terminal domain interface [polypeptide binding]; other site 1033813009970 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1033813009971 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1033813009972 23S rRNA interface [nucleotide binding]; other site 1033813009973 L3 interface [polypeptide binding]; other site 1033813009974 Predicted ATPase [General function prediction only]; Region: COG1485 1033813009975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1033813009976 hypothetical protein; Provisional; Region: PRK11677 1033813009977 serine endoprotease; Provisional; Region: PRK10139 1033813009978 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1033813009979 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1033813009980 protein binding site [polypeptide binding]; other site 1033813009981 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1033813009982 serine endoprotease; Provisional; Region: PRK10898 1033813009983 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1033813009984 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1033813009985 malate dehydrogenase; Provisional; Region: PRK05086 1033813009986 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1033813009987 NAD binding site [chemical binding]; other site 1033813009988 dimerization interface [polypeptide binding]; other site 1033813009989 Substrate binding site [chemical binding]; other site 1033813009990 arginine repressor; Provisional; Region: PRK05066 1033813009991 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1033813009992 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1033813009993 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1033813009994 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1033813009995 RNAase interaction site [polypeptide binding]; other site 1033813009996 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1033813009997 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1033813009998 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1033813009999 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813010000 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813010001 efflux system membrane protein; Provisional; Region: PRK11594 1033813010002 transcriptional regulator; Provisional; Region: PRK10632 1033813010003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813010004 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1033813010005 putative effector binding pocket; other site 1033813010006 dimerization interface [polypeptide binding]; other site 1033813010007 protease TldD; Provisional; Region: tldD; PRK10735 1033813010008 hypothetical protein; Provisional; Region: PRK10899 1033813010009 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1033813010010 ribonuclease G; Provisional; Region: PRK11712 1033813010011 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1033813010012 homodimer interface [polypeptide binding]; other site 1033813010013 oligonucleotide binding site [chemical binding]; other site 1033813010014 Maf-like protein; Region: Maf; pfam02545 1033813010015 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1033813010016 active site 1033813010017 dimer interface [polypeptide binding]; other site 1033813010018 rod shape-determining protein MreD; Provisional; Region: PRK11060 1033813010019 rod shape-determining protein MreC; Region: mreC; TIGR00219 1033813010020 rod shape-determining protein MreC; Region: MreC; pfam04085 1033813010021 rod shape-determining protein MreB; Provisional; Region: PRK13927 1033813010022 MreB and similar proteins; Region: MreB_like; cd10225 1033813010023 nucleotide binding site [chemical binding]; other site 1033813010024 Mg binding site [ion binding]; other site 1033813010025 putative protofilament interaction site [polypeptide binding]; other site 1033813010026 RodZ interaction site [polypeptide binding]; other site 1033813010027 regulatory protein CsrD; Provisional; Region: PRK11059 1033813010028 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813010029 metal binding site [ion binding]; metal-binding site 1033813010030 active site 1033813010031 I-site; other site 1033813010032 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813010033 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1033813010034 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1033813010035 NADP binding site [chemical binding]; other site 1033813010036 dimer interface [polypeptide binding]; other site 1033813010037 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1033813010038 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1033813010039 carboxyltransferase (CT) interaction site; other site 1033813010040 biotinylation site [posttranslational modification]; other site 1033813010041 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1033813010042 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1033813010043 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1033813010044 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1033813010045 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1033813010046 active site 1033813010047 catalytic residues [active] 1033813010048 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1033813010049 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1033813010050 substrate binding site [chemical binding]; other site 1033813010051 ATP binding site [chemical binding]; other site 1033813010052 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033813010053 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1033813010054 TM-ABC transporter signature motif; other site 1033813010055 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1033813010056 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1033813010057 Walker A/P-loop; other site 1033813010058 ATP binding site [chemical binding]; other site 1033813010059 Q-loop/lid; other site 1033813010060 ABC transporter signature motif; other site 1033813010061 Walker B; other site 1033813010062 D-loop; other site 1033813010063 H-loop/switch region; other site 1033813010064 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1033813010065 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1033813010066 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 1033813010067 putative ligand binding site [chemical binding]; other site 1033813010068 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1033813010069 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1033813010070 intersubunit interface [polypeptide binding]; other site 1033813010071 active site 1033813010072 zinc binding site [ion binding]; other site 1033813010073 Na+ binding site [ion binding]; other site 1033813010074 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1033813010075 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1033813010076 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813010077 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1033813010078 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1033813010079 substrate binding site [chemical binding]; other site 1033813010080 ATP binding site [chemical binding]; other site 1033813010081 hypothetical protein; Provisional; Region: PRK10633 1033813010082 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1033813010083 Na binding site [ion binding]; other site 1033813010084 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1033813010085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1033813010086 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 1033813010087 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1033813010088 FMN binding site [chemical binding]; other site 1033813010089 active site 1033813010090 catalytic residues [active] 1033813010091 substrate binding site [chemical binding]; other site 1033813010092 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1033813010093 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1033813010094 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1033813010095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813010096 DNA methylase; Region: N6_N4_Mtase; pfam01555 1033813010097 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1033813010098 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1033813010099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813010100 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1033813010101 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1033813010102 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813010103 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813010104 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1033813010105 Protein export membrane protein; Region: SecD_SecF; cl14618 1033813010106 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1033813010107 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1033813010108 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813010109 substrate binding pocket [chemical binding]; other site 1033813010110 membrane-bound complex binding site; other site 1033813010111 hinge residues; other site 1033813010112 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1033813010113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813010114 conserved gate region; other site 1033813010115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813010116 dimer interface [polypeptide binding]; other site 1033813010117 conserved gate region; other site 1033813010118 putative PBP binding loops; other site 1033813010119 ABC-ATPase subunit interface; other site 1033813010120 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1033813010121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813010122 dimer interface [polypeptide binding]; other site 1033813010123 conserved gate region; other site 1033813010124 putative PBP binding loops; other site 1033813010125 ABC-ATPase subunit interface; other site 1033813010126 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1033813010127 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1033813010128 Walker A/P-loop; other site 1033813010129 ATP binding site [chemical binding]; other site 1033813010130 Q-loop/lid; other site 1033813010131 ABC transporter signature motif; other site 1033813010132 Walker B; other site 1033813010133 D-loop; other site 1033813010134 H-loop/switch region; other site 1033813010135 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1033813010136 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1033813010137 trimer interface [polypeptide binding]; other site 1033813010138 putative metal binding site [ion binding]; other site 1033813010139 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1033813010140 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1033813010141 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1033813010142 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1033813010143 shikimate binding site; other site 1033813010144 NAD(P) binding site [chemical binding]; other site 1033813010145 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1033813010146 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1033813010147 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1033813010148 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1033813010149 hypothetical protein; Validated; Region: PRK03430 1033813010150 hypothetical protein; Provisional; Region: PRK10736 1033813010151 DNA protecting protein DprA; Region: dprA; TIGR00732 1033813010152 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1033813010153 active site 1033813010154 catalytic residues [active] 1033813010155 metal binding site [ion binding]; metal-binding site 1033813010156 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1033813010157 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1033813010158 putative active site [active] 1033813010159 substrate binding site [chemical binding]; other site 1033813010160 putative cosubstrate binding site; other site 1033813010161 catalytic site [active] 1033813010162 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1033813010163 substrate binding site [chemical binding]; other site 1033813010164 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1033813010165 putative RNA binding site [nucleotide binding]; other site 1033813010166 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1033813010167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813010168 S-adenosylmethionine binding site [chemical binding]; other site 1033813010169 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1033813010170 TrkA-N domain; Region: TrkA_N; pfam02254 1033813010171 TrkA-C domain; Region: TrkA_C; pfam02080 1033813010172 TrkA-N domain; Region: TrkA_N; pfam02254 1033813010173 TrkA-C domain; Region: TrkA_C; pfam02080 1033813010174 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1033813010175 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1033813010176 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1033813010177 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1033813010178 DNA binding residues [nucleotide binding] 1033813010179 dimer interface [polypeptide binding]; other site 1033813010180 metal binding site [ion binding]; metal-binding site 1033813010181 hypothetical protein; Provisional; Region: PRK10203 1033813010182 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1033813010183 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1033813010184 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1033813010185 alphaNTD homodimer interface [polypeptide binding]; other site 1033813010186 alphaNTD - beta interaction site [polypeptide binding]; other site 1033813010187 alphaNTD - beta' interaction site [polypeptide binding]; other site 1033813010188 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1033813010189 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1033813010190 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1033813010191 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033813010192 RNA binding surface [nucleotide binding]; other site 1033813010193 30S ribosomal protein S11; Validated; Region: PRK05309 1033813010194 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1033813010195 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1033813010196 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1033813010197 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1033813010198 SecY translocase; Region: SecY; pfam00344 1033813010199 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1033813010200 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1033813010201 23S rRNA binding site [nucleotide binding]; other site 1033813010202 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1033813010203 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1033813010204 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1033813010205 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1033813010206 23S rRNA interface [nucleotide binding]; other site 1033813010207 5S rRNA interface [nucleotide binding]; other site 1033813010208 L27 interface [polypeptide binding]; other site 1033813010209 L5 interface [polypeptide binding]; other site 1033813010210 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1033813010211 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1033813010212 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1033813010213 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1033813010214 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1033813010215 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1033813010216 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1033813010217 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1033813010218 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1033813010219 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1033813010220 RNA binding site [nucleotide binding]; other site 1033813010221 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1033813010222 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1033813010223 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1033813010224 23S rRNA interface [nucleotide binding]; other site 1033813010225 putative translocon interaction site; other site 1033813010226 signal recognition particle (SRP54) interaction site; other site 1033813010227 L23 interface [polypeptide binding]; other site 1033813010228 trigger factor interaction site; other site 1033813010229 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1033813010230 23S rRNA interface [nucleotide binding]; other site 1033813010231 5S rRNA interface [nucleotide binding]; other site 1033813010232 putative antibiotic binding site [chemical binding]; other site 1033813010233 L25 interface [polypeptide binding]; other site 1033813010234 L27 interface [polypeptide binding]; other site 1033813010235 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1033813010236 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1033813010237 G-X-X-G motif; other site 1033813010238 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1033813010239 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1033813010240 protein-rRNA interface [nucleotide binding]; other site 1033813010241 putative translocon binding site; other site 1033813010242 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1033813010243 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1033813010244 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1033813010245 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1033813010246 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1033813010247 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1033813010248 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1033813010249 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1033813010250 protein secretion protein GspB; Provisional; Region: PRK09697 1033813010251 AAA domain; Region: AAA_22; pfam13401 1033813010252 AAA ATPase domain; Region: AAA_16; pfam13191 1033813010253 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1033813010254 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 1033813010255 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1033813010256 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1033813010257 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1033813010258 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1033813010259 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1033813010260 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1033813010261 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1033813010262 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1033813010263 Walker A motif; other site 1033813010264 ATP binding site [chemical binding]; other site 1033813010265 Walker B motif; other site 1033813010266 type II secretion system protein F; Region: GspF; TIGR02120 1033813010267 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1033813010268 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1033813010269 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1033813010270 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1033813010271 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1033813010272 Type II transport protein GspH; Region: GspH; pfam12019 1033813010273 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1033813010274 type II secretion system protein I; Region: gspI; TIGR01707 1033813010275 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1033813010276 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 1033813010277 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1033813010278 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1033813010279 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 1033813010280 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 1033813010281 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1033813010282 GspL periplasmic domain; Region: GspL_C; pfam12693 1033813010283 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1033813010284 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1033813010285 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1033813010286 heme binding site [chemical binding]; other site 1033813010287 ferroxidase pore; other site 1033813010288 ferroxidase diiron center [ion binding]; other site 1033813010289 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1033813010290 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 1033813010291 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 1033813010292 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1033813010293 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1033813010294 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 1033813010295 active site 1033813010296 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1033813010297 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1033813010298 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1033813010299 purine monophosphate binding site [chemical binding]; other site 1033813010300 dimer interface [polypeptide binding]; other site 1033813010301 putative catalytic residues [active] 1033813010302 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1033813010303 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1033813010304 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1033813010305 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1033813010306 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1033813010307 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 1033813010308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813010309 active site 1033813010310 phosphorylation site [posttranslational modification] 1033813010311 intermolecular recognition site; other site 1033813010312 dimerization interface [polypeptide binding]; other site 1033813010313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813010314 Walker A motif; other site 1033813010315 ATP binding site [chemical binding]; other site 1033813010316 Walker B motif; other site 1033813010317 arginine finger; other site 1033813010318 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1033813010319 sensor protein ZraS; Provisional; Region: PRK10364 1033813010320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813010321 dimer interface [polypeptide binding]; other site 1033813010322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813010323 ATP binding site [chemical binding]; other site 1033813010324 Mg2+ binding site [ion binding]; other site 1033813010325 G-X-G motif; other site 1033813010326 zinc resistance protein; Provisional; Region: zraP; PRK11546 1033813010327 dimer interface [polypeptide binding]; other site 1033813010328 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1033813010329 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1033813010330 IHF dimer interface [polypeptide binding]; other site 1033813010331 IHF - DNA interface [nucleotide binding]; other site 1033813010332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1033813010333 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1033813010334 Active_site [active] 1033813010335 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1033813010336 substrate binding site [chemical binding]; other site 1033813010337 active site 1033813010338 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1033813010339 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1033813010340 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1033813010341 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1033813010342 putative NADH binding site [chemical binding]; other site 1033813010343 putative active site [active] 1033813010344 nudix motif; other site 1033813010345 putative metal binding site [ion binding]; other site 1033813010346 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 1033813010347 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1033813010348 ThiC-associated domain; Region: ThiC-associated; pfam13667 1033813010349 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1033813010350 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1033813010351 thiamine phosphate binding site [chemical binding]; other site 1033813010352 active site 1033813010353 pyrophosphate binding site [ion binding]; other site 1033813010354 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1033813010355 ThiS interaction site; other site 1033813010356 putative active site [active] 1033813010357 tetramer interface [polypeptide binding]; other site 1033813010358 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1033813010359 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813010360 FeS/SAM binding site; other site 1033813010361 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1033813010362 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1033813010363 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1033813010364 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1033813010365 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1033813010366 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1033813010367 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1033813010368 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1033813010369 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1033813010370 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1033813010371 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1033813010372 DNA binding site [nucleotide binding] 1033813010373 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1033813010374 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1033813010375 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1033813010376 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1033813010377 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1033813010378 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1033813010379 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1033813010380 RPB3 interaction site [polypeptide binding]; other site 1033813010381 RPB1 interaction site [polypeptide binding]; other site 1033813010382 RPB11 interaction site [polypeptide binding]; other site 1033813010383 RPB10 interaction site [polypeptide binding]; other site 1033813010384 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1033813010385 core dimer interface [polypeptide binding]; other site 1033813010386 peripheral dimer interface [polypeptide binding]; other site 1033813010387 L10 interface [polypeptide binding]; other site 1033813010388 L11 interface [polypeptide binding]; other site 1033813010389 putative EF-Tu interaction site [polypeptide binding]; other site 1033813010390 putative EF-G interaction site [polypeptide binding]; other site 1033813010391 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1033813010392 23S rRNA interface [nucleotide binding]; other site 1033813010393 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1033813010394 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1033813010395 mRNA/rRNA interface [nucleotide binding]; other site 1033813010396 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1033813010397 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1033813010398 23S rRNA interface [nucleotide binding]; other site 1033813010399 L7/L12 interface [polypeptide binding]; other site 1033813010400 putative thiostrepton binding site; other site 1033813010401 L25 interface [polypeptide binding]; other site 1033813010402 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1033813010403 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1033813010404 putative homodimer interface [polypeptide binding]; other site 1033813010405 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1033813010406 heterodimer interface [polypeptide binding]; other site 1033813010407 homodimer interface [polypeptide binding]; other site 1033813010408 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1033813010409 elongation factor Tu; Reviewed; Region: PRK00049 1033813010410 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1033813010411 G1 box; other site 1033813010412 GEF interaction site [polypeptide binding]; other site 1033813010413 GTP/Mg2+ binding site [chemical binding]; other site 1033813010414 Switch I region; other site 1033813010415 G2 box; other site 1033813010416 G3 box; other site 1033813010417 Switch II region; other site 1033813010418 G4 box; other site 1033813010419 G5 box; other site 1033813010420 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1033813010421 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1033813010422 Antibiotic Binding Site [chemical binding]; other site 1033813010423 elongation factor G; Reviewed; Region: PRK00007 1033813010424 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1033813010425 G1 box; other site 1033813010426 putative GEF interaction site [polypeptide binding]; other site 1033813010427 GTP/Mg2+ binding site [chemical binding]; other site 1033813010428 Switch I region; other site 1033813010429 G2 box; other site 1033813010430 G3 box; other site 1033813010431 Switch II region; other site 1033813010432 G4 box; other site 1033813010433 G5 box; other site 1033813010434 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1033813010435 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1033813010436 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1033813010437 30S ribosomal protein S7; Validated; Region: PRK05302 1033813010438 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1033813010439 S17 interaction site [polypeptide binding]; other site 1033813010440 S8 interaction site; other site 1033813010441 16S rRNA interaction site [nucleotide binding]; other site 1033813010442 streptomycin interaction site [chemical binding]; other site 1033813010443 23S rRNA interaction site [nucleotide binding]; other site 1033813010444 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1033813010445 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1033813010446 sulfur relay protein TusC; Validated; Region: PRK00211 1033813010447 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1033813010448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1033813010449 YheO-like PAS domain; Region: PAS_6; pfam08348 1033813010450 HTH domain; Region: HTH_22; pfam13309 1033813010451 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1033813010452 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1033813010453 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1033813010454 phi X174 lysis protein; Provisional; Region: PRK02793 1033813010455 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1033813010456 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1033813010457 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1033813010458 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1033813010459 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1033813010460 TrkA-N domain; Region: TrkA_N; pfam02254 1033813010461 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1033813010462 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1033813010463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813010464 Walker A/P-loop; other site 1033813010465 ATP binding site [chemical binding]; other site 1033813010466 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033813010467 ABC transporter signature motif; other site 1033813010468 Walker B; other site 1033813010469 D-loop; other site 1033813010470 ABC transporter; Region: ABC_tran_2; pfam12848 1033813010471 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033813010472 putative hydrolase; Provisional; Region: PRK10985 1033813010473 hypothetical protein; Provisional; Region: PRK04966 1033813010474 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1033813010475 active site 1033813010476 hypothetical protein; Provisional; Region: PRK10738 1033813010477 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1033813010478 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1033813010479 ligand binding site [chemical binding]; other site 1033813010480 flexible hinge region; other site 1033813010481 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1033813010482 putative switch regulator; other site 1033813010483 non-specific DNA interactions [nucleotide binding]; other site 1033813010484 DNA binding site [nucleotide binding] 1033813010485 sequence specific DNA binding site [nucleotide binding]; other site 1033813010486 putative cAMP binding site [chemical binding]; other site 1033813010487 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1033813010488 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1033813010489 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1033813010490 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1033813010491 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1033813010492 inhibitor-cofactor binding pocket; inhibition site 1033813010493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813010494 catalytic residue [active] 1033813010495 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1033813010496 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1033813010497 glutamine binding [chemical binding]; other site 1033813010498 catalytic triad [active] 1033813010499 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1033813010500 cell filamentation protein Fic; Provisional; Region: PRK10347 1033813010501 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1033813010502 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1033813010503 substrate binding site [chemical binding]; other site 1033813010504 putative transporter; Provisional; Region: PRK03699 1033813010505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813010506 putative substrate translocation pore; other site 1033813010507 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1033813010508 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813010509 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1033813010510 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1033813010511 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1033813010512 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1033813010513 nitrite transporter NirC; Provisional; Region: PRK11562 1033813010514 siroheme synthase; Provisional; Region: cysG; PRK10637 1033813010515 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1033813010516 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1033813010517 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1033813010518 active site 1033813010519 SAM binding site [chemical binding]; other site 1033813010520 homodimer interface [polypeptide binding]; other site 1033813010521 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1033813010522 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 1033813010523 Protein of unknown function; Region: YhfT; pfam10797 1033813010524 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 1033813010525 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1033813010526 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1033813010527 active site 1033813010528 substrate binding pocket [chemical binding]; other site 1033813010529 homodimer interaction site [polypeptide binding]; other site 1033813010530 putative mutase; Provisional; Region: PRK12383 1033813010531 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 1033813010532 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 1033813010533 dimer interface [polypeptide binding]; other site 1033813010534 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1033813010535 active site 1033813010536 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1033813010537 substrate binding site [chemical binding]; other site 1033813010538 catalytic residue [active] 1033813010539 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1033813010540 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1033813010541 active site 1033813010542 HIGH motif; other site 1033813010543 dimer interface [polypeptide binding]; other site 1033813010544 KMSKS motif; other site 1033813010545 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1033813010546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813010547 motif II; other site 1033813010548 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1033813010549 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1033813010550 substrate binding site [chemical binding]; other site 1033813010551 hexamer interface [polypeptide binding]; other site 1033813010552 metal binding site [ion binding]; metal-binding site 1033813010553 DNA adenine methylase; Provisional; Region: PRK10904 1033813010554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1033813010555 cell division protein DamX; Validated; Region: PRK10905 1033813010556 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1033813010557 active site 1033813010558 dimer interface [polypeptide binding]; other site 1033813010559 metal binding site [ion binding]; metal-binding site 1033813010560 shikimate kinase; Reviewed; Region: aroK; PRK00131 1033813010561 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1033813010562 ADP binding site [chemical binding]; other site 1033813010563 magnesium binding site [ion binding]; other site 1033813010564 putative shikimate binding site; other site 1033813010565 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1033813010566 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1033813010567 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1033813010568 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1033813010569 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1033813010570 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1033813010571 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1033813010572 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1033813010573 Transglycosylase; Region: Transgly; pfam00912 1033813010574 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1033813010575 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1033813010576 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1033813010577 ADP-ribose binding site [chemical binding]; other site 1033813010578 dimer interface [polypeptide binding]; other site 1033813010579 active site 1033813010580 nudix motif; other site 1033813010581 metal binding site [ion binding]; metal-binding site 1033813010582 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1033813010583 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1033813010584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813010585 motif II; other site 1033813010586 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033813010587 RNA binding surface [nucleotide binding]; other site 1033813010588 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1033813010589 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1033813010590 dimerization interface [polypeptide binding]; other site 1033813010591 domain crossover interface; other site 1033813010592 redox-dependent activation switch; other site 1033813010593 Probable transposase; Region: OrfB_IS605; pfam01385 1033813010594 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033813010595 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1033813010596 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1033813010597 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1033813010598 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1033813010599 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1033813010600 Flagellar protein FliS; Region: FliS; cl00654 1033813010601 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 1033813010602 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1033813010603 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1033813010604 active site 1033813010605 Na/Ca binding site [ion binding]; other site 1033813010606 catalytic site [active] 1033813010607 lipoprotein; Provisional; Region: PRK10397 1033813010608 putative inner membrane protein; Provisional; Region: PRK11099 1033813010609 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1033813010610 CPxP motif; other site 1033813010611 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1033813010612 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1033813010613 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1033813010614 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1033813010615 active site 1033813010616 substrate-binding site [chemical binding]; other site 1033813010617 metal-binding site [ion binding] 1033813010618 ATP binding site [chemical binding]; other site 1033813010619 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1033813010620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033813010621 dimerization interface [polypeptide binding]; other site 1033813010622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813010623 dimer interface [polypeptide binding]; other site 1033813010624 phosphorylation site [posttranslational modification] 1033813010625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813010626 ATP binding site [chemical binding]; other site 1033813010627 G-X-G motif; other site 1033813010628 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1033813010629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813010630 active site 1033813010631 phosphorylation site [posttranslational modification] 1033813010632 intermolecular recognition site; other site 1033813010633 dimerization interface [polypeptide binding]; other site 1033813010634 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813010635 DNA binding site [nucleotide binding] 1033813010636 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1033813010637 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1033813010638 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1033813010639 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1033813010640 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1033813010641 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1033813010642 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1033813010643 RNA binding site [nucleotide binding]; other site 1033813010644 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1033813010645 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1033813010646 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1033813010647 G1 box; other site 1033813010648 GTP/Mg2+ binding site [chemical binding]; other site 1033813010649 Switch I region; other site 1033813010650 G2 box; other site 1033813010651 G3 box; other site 1033813010652 Switch II region; other site 1033813010653 G4 box; other site 1033813010654 G5 box; other site 1033813010655 Nucleoside recognition; Region: Gate; pfam07670 1033813010656 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1033813010657 Nucleoside recognition; Region: Gate; pfam07670 1033813010658 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1033813010659 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1033813010660 carboxylesterase BioH; Provisional; Region: PRK10349 1033813010661 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1033813010662 DNA utilization protein GntX; Provisional; Region: PRK11595 1033813010663 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033813010664 active site 1033813010665 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1033813010666 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1033813010667 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1033813010668 high-affinity gluconate transporter; Provisional; Region: PRK14984 1033813010669 gluconate transporter; Region: gntP; TIGR00791 1033813010670 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1033813010671 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1033813010672 maltodextrin phosphorylase; Provisional; Region: PRK14985 1033813010673 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1033813010674 homodimer interface [polypeptide binding]; other site 1033813010675 active site pocket [active] 1033813010676 transcriptional regulator MalT; Provisional; Region: PRK04841 1033813010677 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813010678 DNA binding residues [nucleotide binding] 1033813010679 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1033813010680 putative active site [active] 1033813010681 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1033813010682 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1033813010683 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1033813010684 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813010685 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1033813010686 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1033813010687 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1033813010688 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1033813010689 active site residue [active] 1033813010690 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1033813010691 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1033813010692 glycogen phosphorylase; Provisional; Region: PRK14986 1033813010693 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1033813010694 homodimer interface [polypeptide binding]; other site 1033813010695 active site pocket [active] 1033813010696 glycogen synthase; Provisional; Region: glgA; PRK00654 1033813010697 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1033813010698 ADP-binding pocket [chemical binding]; other site 1033813010699 homodimer interface [polypeptide binding]; other site 1033813010700 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1033813010701 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1033813010702 ligand binding site; other site 1033813010703 oligomer interface; other site 1033813010704 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1033813010705 sulfate 1 binding site; other site 1033813010706 glycogen debranching enzyme; Provisional; Region: PRK03705 1033813010707 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1033813010708 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1033813010709 active site 1033813010710 catalytic site [active] 1033813010711 glycogen branching enzyme; Provisional; Region: PRK05402 1033813010712 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1033813010713 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1033813010714 active site 1033813010715 catalytic site [active] 1033813010716 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1033813010717 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1033813010718 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1033813010719 putative antibiotic transporter; Provisional; Region: PRK10739 1033813010720 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1033813010721 DNA protecting protein DprA; Region: dprA; TIGR00732 1033813010722 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1033813010723 non-specific DNA interactions [nucleotide binding]; other site 1033813010724 DNA binding site [nucleotide binding] 1033813010725 sequence specific DNA binding site [nucleotide binding]; other site 1033813010726 putative cAMP binding site [chemical binding]; other site 1033813010727 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1033813010728 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033813010729 ATP binding site [chemical binding]; other site 1033813010730 putative Mg++ binding site [ion binding]; other site 1033813010731 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813010732 nucleotide binding region [chemical binding]; other site 1033813010733 ATP-binding site [chemical binding]; other site 1033813010734 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033813010735 active site 1033813010736 low affinity gluconate transporter; Provisional; Region: PRK10472 1033813010737 gluconate transporter; Region: gntP; TIGR00791 1033813010738 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1033813010739 Shikimate kinase; Region: SKI; pfam01202 1033813010740 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1033813010741 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813010742 DNA binding site [nucleotide binding] 1033813010743 domain linker motif; other site 1033813010744 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1033813010745 putative ligand binding site [chemical binding]; other site 1033813010746 putative dimerization interface [polypeptide binding]; other site 1033813010747 Pirin-related protein [General function prediction only]; Region: COG1741 1033813010748 Pirin; Region: Pirin; pfam02678 1033813010749 putative oxidoreductase; Provisional; Region: PRK10206 1033813010750 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1033813010751 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1033813010752 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1033813010753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813010754 Coenzyme A binding pocket [chemical binding]; other site 1033813010755 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1033813010756 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1033813010757 hypothetical protein; Provisional; Region: PRK10350 1033813010758 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1033813010759 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1033813010760 putative active site [active] 1033813010761 catalytic site [active] 1033813010762 putative metal binding site [ion binding]; other site 1033813010763 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1033813010764 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1033813010765 Walker A/P-loop; other site 1033813010766 ATP binding site [chemical binding]; other site 1033813010767 Q-loop/lid; other site 1033813010768 ABC transporter signature motif; other site 1033813010769 Walker B; other site 1033813010770 D-loop; other site 1033813010771 H-loop/switch region; other site 1033813010772 TOBE domain; Region: TOBE_2; pfam08402 1033813010773 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1033813010774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813010775 dimer interface [polypeptide binding]; other site 1033813010776 conserved gate region; other site 1033813010777 putative PBP binding loops; other site 1033813010778 ABC-ATPase subunit interface; other site 1033813010779 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1033813010780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813010781 dimer interface [polypeptide binding]; other site 1033813010782 conserved gate region; other site 1033813010783 putative PBP binding loops; other site 1033813010784 ABC-ATPase subunit interface; other site 1033813010785 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1033813010786 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1033813010787 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1033813010788 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1033813010789 Walker A/P-loop; other site 1033813010790 ATP binding site [chemical binding]; other site 1033813010791 Q-loop/lid; other site 1033813010792 ABC transporter signature motif; other site 1033813010793 Walker B; other site 1033813010794 D-loop; other site 1033813010795 H-loop/switch region; other site 1033813010796 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1033813010797 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1033813010798 Walker A/P-loop; other site 1033813010799 ATP binding site [chemical binding]; other site 1033813010800 Q-loop/lid; other site 1033813010801 ABC transporter signature motif; other site 1033813010802 Walker B; other site 1033813010803 D-loop; other site 1033813010804 H-loop/switch region; other site 1033813010805 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1033813010806 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1033813010807 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1033813010808 TM-ABC transporter signature motif; other site 1033813010809 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033813010810 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1033813010811 TM-ABC transporter signature motif; other site 1033813010812 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1033813010813 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1033813010814 dimerization interface [polypeptide binding]; other site 1033813010815 ligand binding site [chemical binding]; other site 1033813010816 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1033813010817 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1033813010818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1033813010819 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1033813010820 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1033813010821 dimerization interface [polypeptide binding]; other site 1033813010822 ligand binding site [chemical binding]; other site 1033813010823 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1033813010824 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1033813010825 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1033813010826 DNA binding residues [nucleotide binding] 1033813010827 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1033813010828 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1033813010829 cell division protein FtsE; Provisional; Region: PRK10908 1033813010830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813010831 Walker A/P-loop; other site 1033813010832 ATP binding site [chemical binding]; other site 1033813010833 Q-loop/lid; other site 1033813010834 ABC transporter signature motif; other site 1033813010835 Walker B; other site 1033813010836 D-loop; other site 1033813010837 H-loop/switch region; other site 1033813010838 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1033813010839 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1033813010840 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1033813010841 P loop; other site 1033813010842 GTP binding site [chemical binding]; other site 1033813010843 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1033813010844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813010845 S-adenosylmethionine binding site [chemical binding]; other site 1033813010846 hypothetical protein; Provisional; Region: PRK10910 1033813010847 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1033813010848 Predicted membrane protein [Function unknown]; Region: COG3714 1033813010849 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1033813010850 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1033813010851 metal-binding site [ion binding] 1033813010852 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033813010853 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1033813010854 CPxP motif; other site 1033813010855 hypothetical protein; Provisional; Region: PRK11212 1033813010856 hypothetical protein; Provisional; Region: PRK11615 1033813010857 major facilitator superfamily transporter; Provisional; Region: PRK05122 1033813010858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813010859 putative substrate translocation pore; other site 1033813010860 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1033813010861 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1033813010862 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1033813010863 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1033813010864 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1033813010865 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1033813010866 substrate binding site [chemical binding]; other site 1033813010867 nickel transporter permease NikB; Provisional; Region: PRK10352 1033813010868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813010869 dimer interface [polypeptide binding]; other site 1033813010870 conserved gate region; other site 1033813010871 putative PBP binding loops; other site 1033813010872 ABC-ATPase subunit interface; other site 1033813010873 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1033813010874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813010875 dimer interface [polypeptide binding]; other site 1033813010876 conserved gate region; other site 1033813010877 putative PBP binding loops; other site 1033813010878 ABC-ATPase subunit interface; other site 1033813010879 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 1033813010880 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813010881 Walker A/P-loop; other site 1033813010882 ATP binding site [chemical binding]; other site 1033813010883 Q-loop/lid; other site 1033813010884 ABC transporter signature motif; other site 1033813010885 Walker B; other site 1033813010886 D-loop; other site 1033813010887 H-loop/switch region; other site 1033813010888 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1033813010889 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 1033813010890 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813010891 Walker A/P-loop; other site 1033813010892 ATP binding site [chemical binding]; other site 1033813010893 Q-loop/lid; other site 1033813010894 ABC transporter signature motif; other site 1033813010895 Walker B; other site 1033813010896 D-loop; other site 1033813010897 H-loop/switch region; other site 1033813010898 nickel responsive regulator; Provisional; Region: PRK02967 1033813010899 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1033813010900 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1033813010901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813010902 DNA-binding site [nucleotide binding]; DNA binding site 1033813010903 UTRA domain; Region: UTRA; pfam07702 1033813010904 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033813010905 active site 1033813010906 phosphorylation site [posttranslational modification] 1033813010907 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1033813010908 active site 1033813010909 P-loop; other site 1033813010910 phosphorylation site [posttranslational modification] 1033813010911 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1033813010912 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1033813010913 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1033813010914 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 1033813010915 putative N- and C-terminal domain interface [polypeptide binding]; other site 1033813010916 putative active site [active] 1033813010917 putative MgATP binding site [chemical binding]; other site 1033813010918 catalytic site [active] 1033813010919 metal binding site [ion binding]; metal-binding site 1033813010920 putative carbohydrate binding site [chemical binding]; other site 1033813010921 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1033813010922 dimerization domain swap beta strand [polypeptide binding]; other site 1033813010923 regulatory protein interface [polypeptide binding]; other site 1033813010924 active site 1033813010925 regulatory phosphorylation site [posttranslational modification]; other site 1033813010926 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1033813010927 intersubunit interface [polypeptide binding]; other site 1033813010928 active site 1033813010929 zinc binding site [ion binding]; other site 1033813010930 Na+ binding site [ion binding]; other site 1033813010931 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1033813010932 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1033813010933 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1033813010934 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1033813010935 Walker A/P-loop; other site 1033813010936 ATP binding site [chemical binding]; other site 1033813010937 Q-loop/lid; other site 1033813010938 ABC transporter signature motif; other site 1033813010939 Walker B; other site 1033813010940 D-loop; other site 1033813010941 H-loop/switch region; other site 1033813010942 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1033813010943 Walker A/P-loop; other site 1033813010944 ATP binding site [chemical binding]; other site 1033813010945 Q-loop/lid; other site 1033813010946 ABC transporter signature motif; other site 1033813010947 Walker B; other site 1033813010948 D-loop; other site 1033813010949 H-loop/switch region; other site 1033813010950 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1033813010951 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1033813010952 HlyD family secretion protein; Region: HlyD; pfam00529 1033813010953 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813010954 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813010955 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 1033813010956 Predicted flavoproteins [General function prediction only]; Region: COG2081 1033813010957 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1033813010958 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1033813010959 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1033813010960 universal stress protein UspB; Provisional; Region: PRK04960 1033813010961 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1033813010962 Ligand Binding Site [chemical binding]; other site 1033813010963 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1033813010964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813010965 POT family; Region: PTR2; pfam00854 1033813010966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813010967 S-adenosylmethionine binding site [chemical binding]; other site 1033813010968 oligopeptidase A; Provisional; Region: PRK10911 1033813010969 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1033813010970 active site 1033813010971 Zn binding site [ion binding]; other site 1033813010972 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1033813010973 glutathione reductase; Validated; Region: PRK06116 1033813010974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1033813010975 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813010976 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1033813010977 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1033813010978 ArsC family; Region: ArsC; pfam03960 1033813010979 catalytic residues [active] 1033813010980 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 1033813010981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813010982 DNA binding residues [nucleotide binding] 1033813010983 dimerization interface [polypeptide binding]; other site 1033813010984 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1033813010985 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1033813010986 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1033813010987 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1033813010988 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813010989 N-terminal plug; other site 1033813010990 ligand-binding site [chemical binding]; other site 1033813010991 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1033813010992 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1033813010993 putative hemin binding site; other site 1033813010994 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 1033813010995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813010996 FeS/SAM binding site; other site 1033813010997 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 1033813010998 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1033813010999 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1033813011000 NAD(P) binding site [chemical binding]; other site 1033813011001 putative active site [active] 1033813011002 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1033813011003 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1033813011004 ABC-ATPase subunit interface; other site 1033813011005 dimer interface [polypeptide binding]; other site 1033813011006 putative PBP binding regions; other site 1033813011007 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 1033813011008 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1033813011009 Walker A/P-loop; other site 1033813011010 ATP binding site [chemical binding]; other site 1033813011011 Q-loop/lid; other site 1033813011012 ABC transporter signature motif; other site 1033813011013 Walker B; other site 1033813011014 D-loop; other site 1033813011015 H-loop/switch region; other site 1033813011016 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 1033813011017 MgtC family; Region: MgtC; pfam02308 1033813011018 acid-resistance protein; Provisional; Region: hdeB; PRK11566 1033813011019 acid-resistance protein; Provisional; Region: PRK10208 1033813011020 acid-resistance membrane protein; Provisional; Region: PRK10209 1033813011021 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1033813011022 transcriptional regulator NarP; Provisional; Region: PRK10403 1033813011023 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1033813011024 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813011025 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813011026 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1033813011027 Protein export membrane protein; Region: SecD_SecF; cl14618 1033813011028 transcriptional regulator YdeO; Provisional; Region: PRK09940 1033813011029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813011030 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 1033813011031 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1033813011032 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1033813011033 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1033813011034 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1033813011035 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1033813011036 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1033813011037 hypothetical protein; Provisional; Region: PRK10281 1033813011038 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1033813011039 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1033813011040 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1033813011041 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1033813011042 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1033813011043 [4Fe-4S] binding site [ion binding]; other site 1033813011044 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813011045 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813011046 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813011047 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1033813011048 molybdopterin cofactor binding site; other site 1033813011049 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1033813011050 aromatic amino acid exporter; Provisional; Region: PRK11689 1033813011051 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813011052 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813011053 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813011054 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1033813011055 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1033813011056 molybdopterin cofactor binding site; other site 1033813011057 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1033813011058 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1033813011059 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1033813011060 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1033813011061 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1033813011062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813011063 non-specific DNA binding site [nucleotide binding]; other site 1033813011064 salt bridge; other site 1033813011065 sequence-specific DNA binding site [nucleotide binding]; other site 1033813011066 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1033813011067 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1033813011068 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1033813011069 NAD binding site [chemical binding]; other site 1033813011070 substrate binding site [chemical binding]; other site 1033813011071 catalytic Zn binding site [ion binding]; other site 1033813011072 tetramer interface [polypeptide binding]; other site 1033813011073 structural Zn binding site [ion binding]; other site 1033813011074 malate dehydrogenase; Provisional; Region: PRK13529 1033813011075 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1033813011076 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1033813011077 NAD(P) binding site [chemical binding]; other site 1033813011078 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1033813011079 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 1033813011080 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1033813011081 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 1033813011082 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813011083 putative active site [active] 1033813011084 heme pocket [chemical binding]; other site 1033813011085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813011086 putative active site [active] 1033813011087 heme pocket [chemical binding]; other site 1033813011088 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813011089 metal binding site [ion binding]; metal-binding site 1033813011090 active site 1033813011091 I-site; other site 1033813011092 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813011093 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813011094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1033813011095 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1033813011096 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1033813011097 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1033813011098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813011099 catalytic residue [active] 1033813011100 Haem-binding domain; Region: Haem_bd; pfam14376 1033813011101 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1033813011102 trehalase; Provisional; Region: treF; PRK13270 1033813011103 Trehalase; Region: Trehalase; pfam01204 1033813011104 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1033813011105 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813011106 DNA binding residues [nucleotide binding] 1033813011107 dimerization interface [polypeptide binding]; other site 1033813011108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033813011109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813011110 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1033813011111 putative effector binding pocket; other site 1033813011112 putative dimerization interface [polypeptide binding]; other site 1033813011113 inner membrane protein YhjD; Region: TIGR00766 1033813011114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813011115 metabolite-proton symporter; Region: 2A0106; TIGR00883 1033813011116 putative substrate translocation pore; other site 1033813011117 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1033813011118 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1033813011119 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813011120 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1033813011121 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1033813011122 substrate binding site [chemical binding]; other site 1033813011123 ATP binding site [chemical binding]; other site 1033813011124 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1033813011125 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1033813011126 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1033813011127 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1033813011128 putative diguanylate cyclase; Provisional; Region: PRK13561 1033813011129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1033813011130 metal binding site [ion binding]; metal-binding site 1033813011131 active site 1033813011132 I-site; other site 1033813011133 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813011134 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1033813011135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1033813011136 binding surface 1033813011137 TPR motif; other site 1033813011138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1033813011139 binding surface 1033813011140 TPR motif; other site 1033813011141 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1033813011142 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1033813011143 cellulose synthase regulator protein; Provisional; Region: PRK11114 1033813011144 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1033813011145 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1033813011146 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1033813011147 DXD motif; other site 1033813011148 PilZ domain; Region: PilZ; pfam07238 1033813011149 cell division protein; Provisional; Region: PRK10037 1033813011150 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1033813011151 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1033813011152 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1033813011153 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 1033813011154 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 1033813011155 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1033813011156 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1033813011157 serine transporter; Region: stp; TIGR00814 1033813011158 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1033813011159 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813011160 Walker A/P-loop; other site 1033813011161 ATP binding site [chemical binding]; other site 1033813011162 Q-loop/lid; other site 1033813011163 ABC transporter signature motif; other site 1033813011164 Walker B; other site 1033813011165 D-loop; other site 1033813011166 H-loop/switch region; other site 1033813011167 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1033813011168 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1033813011169 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813011170 Walker A/P-loop; other site 1033813011171 ATP binding site [chemical binding]; other site 1033813011172 Q-loop/lid; other site 1033813011173 ABC transporter signature motif; other site 1033813011174 Walker B; other site 1033813011175 D-loop; other site 1033813011176 H-loop/switch region; other site 1033813011177 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1033813011178 dipeptide transporter; Provisional; Region: PRK10913 1033813011179 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1033813011180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813011181 dimer interface [polypeptide binding]; other site 1033813011182 conserved gate region; other site 1033813011183 putative PBP binding loops; other site 1033813011184 ABC-ATPase subunit interface; other site 1033813011185 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1033813011186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813011187 dimer interface [polypeptide binding]; other site 1033813011188 conserved gate region; other site 1033813011189 putative PBP binding loops; other site 1033813011190 ABC-ATPase subunit interface; other site 1033813011191 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1033813011192 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1033813011193 peptide binding site [polypeptide binding]; other site 1033813011194 phosphoethanolamine transferase; Provisional; Region: PRK11560 1033813011195 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1033813011196 Sulfatase; Region: Sulfatase; pfam00884 1033813011197 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1033813011198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813011199 putative substrate translocation pore; other site 1033813011200 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1033813011201 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 1033813011202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1033813011203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813011204 Coenzyme A binding pocket [chemical binding]; other site 1033813011205 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1033813011206 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1033813011207 molybdopterin cofactor binding site [chemical binding]; other site 1033813011208 substrate binding site [chemical binding]; other site 1033813011209 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1033813011210 molybdopterin cofactor binding site; other site 1033813011211 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1033813011212 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1033813011213 ligand binding site [chemical binding]; other site 1033813011214 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1033813011215 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1033813011216 dimerization interface [polypeptide binding]; other site 1033813011217 ligand binding site [chemical binding]; other site 1033813011218 NADP binding site [chemical binding]; other site 1033813011219 catalytic site [active] 1033813011220 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1033813011221 Predicted transcriptional regulator [Transcription]; Region: COG2944 1033813011222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813011223 non-specific DNA binding site [nucleotide binding]; other site 1033813011224 salt bridge; other site 1033813011225 sequence-specific DNA binding site [nucleotide binding]; other site 1033813011226 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1033813011227 DNA-binding site [nucleotide binding]; DNA binding site 1033813011228 RNA-binding motif; other site 1033813011229 small toxic polypeptide; Provisional; Region: PRK09759 1033813011230 putative transposase OrfB; Reviewed; Region: PHA02517 1033813011231 HTH-like domain; Region: HTH_21; pfam13276 1033813011232 Integrase core domain; Region: rve; pfam00665 1033813011233 Integrase core domain; Region: rve_2; pfam13333 1033813011234 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1033813011235 DALR anticodon binding domain; Region: DALR_1; pfam05746 1033813011236 anticodon binding site; other site 1033813011237 tRNA binding surface [nucleotide binding]; other site 1033813011238 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1033813011239 dimer interface [polypeptide binding]; other site 1033813011240 motif 1; other site 1033813011241 active site 1033813011242 motif 2; other site 1033813011243 motif 3; other site 1033813011244 YsaB-like lipoprotein; Region: YsaB; pfam13983 1033813011245 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1033813011246 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1033813011247 hypothetical protein; Provisional; Region: PRK11383 1033813011248 yiaA/B two helix domain; Region: YiaAB; pfam05360 1033813011249 yiaA/B two helix domain; Region: YiaAB; pfam05360 1033813011250 hypothetical protein; Provisional; Region: PRK11403 1033813011251 yiaA/B two helix domain; Region: YiaAB; pfam05360 1033813011252 xylulokinase; Provisional; Region: PRK15027 1033813011253 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1033813011254 N- and C-terminal domain interface [polypeptide binding]; other site 1033813011255 active site 1033813011256 MgATP binding site [chemical binding]; other site 1033813011257 catalytic site [active] 1033813011258 metal binding site [ion binding]; metal-binding site 1033813011259 xylulose binding site [chemical binding]; other site 1033813011260 homodimer interface [polypeptide binding]; other site 1033813011261 xylose isomerase; Provisional; Region: PRK05474 1033813011262 xylose isomerase; Region: xylose_isom_A; TIGR02630 1033813011263 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1033813011264 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1033813011265 putative ligand binding site [chemical binding]; other site 1033813011266 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1033813011267 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1033813011268 Walker A/P-loop; other site 1033813011269 ATP binding site [chemical binding]; other site 1033813011270 Q-loop/lid; other site 1033813011271 ABC transporter signature motif; other site 1033813011272 Walker B; other site 1033813011273 D-loop; other site 1033813011274 H-loop/switch region; other site 1033813011275 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1033813011276 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033813011277 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1033813011278 TM-ABC transporter signature motif; other site 1033813011279 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1033813011280 putative dimerization interface [polypeptide binding]; other site 1033813011281 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1033813011282 putative ligand binding site [chemical binding]; other site 1033813011283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813011284 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1033813011285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813011286 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1033813011287 hypothetical protein; Provisional; Region: PRK10356 1033813011288 alpha-amylase; Reviewed; Region: malS; PRK09505 1033813011289 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1033813011290 active site 1033813011291 catalytic site [active] 1033813011292 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1033813011293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1033813011294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813011295 homodimer interface [polypeptide binding]; other site 1033813011296 catalytic residue [active] 1033813011297 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1033813011298 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1033813011299 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1033813011300 Bacterial transcriptional regulator; Region: IclR; pfam01614 1033813011301 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1033813011302 Domain of unknown function (DUF386); Region: DUF386; pfam04074 1033813011303 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 1033813011304 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 1033813011305 DctM-like transporters; Region: DctM; pfam06808 1033813011306 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1033813011307 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1033813011308 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1033813011309 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1033813011310 putative N- and C-terminal domain interface [polypeptide binding]; other site 1033813011311 putative active site [active] 1033813011312 MgATP binding site [chemical binding]; other site 1033813011313 catalytic site [active] 1033813011314 metal binding site [ion binding]; metal-binding site 1033813011315 putative xylulose binding site [chemical binding]; other site 1033813011316 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1033813011317 active site 1033813011318 dimer interface [polypeptide binding]; other site 1033813011319 magnesium binding site [ion binding]; other site 1033813011320 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1033813011321 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1033813011322 AP (apurinic/apyrimidinic) site pocket; other site 1033813011323 DNA interaction; other site 1033813011324 Metal-binding active site; metal-binding site 1033813011325 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1033813011326 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1033813011327 intersubunit interface [polypeptide binding]; other site 1033813011328 active site 1033813011329 Zn2+ binding site [ion binding]; other site 1033813011330 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1033813011331 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1033813011332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813011333 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1033813011334 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1033813011335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1033813011336 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1033813011337 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1033813011338 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1033813011339 NAD(P) binding site [chemical binding]; other site 1033813011340 catalytic residues [active] 1033813011341 Fic family protein [Function unknown]; Region: COG3177 1033813011342 Fic/DOC family; Region: Fic; pfam02661 1033813011343 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1033813011344 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1033813011345 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1033813011346 dimer interface [polypeptide binding]; other site 1033813011347 active site 1033813011348 metal binding site [ion binding]; metal-binding site 1033813011349 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1033813011350 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1033813011351 G1 box; other site 1033813011352 putative GEF interaction site [polypeptide binding]; other site 1033813011353 GTP/Mg2+ binding site [chemical binding]; other site 1033813011354 Switch I region; other site 1033813011355 G2 box; other site 1033813011356 G3 box; other site 1033813011357 Switch II region; other site 1033813011358 G4 box; other site 1033813011359 G5 box; other site 1033813011360 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1033813011361 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1033813011362 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1033813011363 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1033813011364 selenocysteine synthase; Provisional; Region: PRK04311 1033813011365 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1033813011366 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1033813011367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1033813011368 catalytic residue [active] 1033813011369 putative glutathione S-transferase; Provisional; Region: PRK10357 1033813011370 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1033813011371 putative C-terminal domain interface [polypeptide binding]; other site 1033813011372 putative GSH binding site (G-site) [chemical binding]; other site 1033813011373 putative dimer interface [polypeptide binding]; other site 1033813011374 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1033813011375 dimer interface [polypeptide binding]; other site 1033813011376 N-terminal domain interface [polypeptide binding]; other site 1033813011377 putative substrate binding pocket (H-site) [chemical binding]; other site 1033813011378 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1033813011379 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813011380 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813011381 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1033813011382 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1033813011383 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1033813011384 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1033813011385 active site 1033813011386 P-loop; other site 1033813011387 phosphorylation site [posttranslational modification] 1033813011388 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033813011389 active site 1033813011390 phosphorylation site [posttranslational modification] 1033813011391 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1033813011392 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1033813011393 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1033813011394 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1033813011395 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1033813011396 hypothetical protein; Provisional; Region: PRK11020 1033813011397 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 1033813011398 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1033813011399 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1033813011400 trimer interface [polypeptide binding]; other site 1033813011401 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1033813011402 trimer interface [polypeptide binding]; other site 1033813011403 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1033813011404 Haemagglutinin; Region: HIM; pfam05662 1033813011405 Haemagglutinin; Region: HIM; pfam05662 1033813011406 YadA-like C-terminal region; Region: YadA; pfam03895 1033813011407 L-lactate permease; Provisional; Region: PRK10420 1033813011408 glycolate transporter; Provisional; Region: PRK09695 1033813011409 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1033813011410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813011411 DNA-binding site [nucleotide binding]; DNA binding site 1033813011412 FCD domain; Region: FCD; pfam07729 1033813011413 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1033813011414 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1033813011415 phosphate binding site [ion binding]; other site 1033813011416 putative rRNA methylase; Provisional; Region: PRK10358 1033813011417 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1033813011418 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1033813011419 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1033813011420 trimer interface [polypeptide binding]; other site 1033813011421 active site 1033813011422 substrate binding site [chemical binding]; other site 1033813011423 CoA binding site [chemical binding]; other site 1033813011424 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1033813011425 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1033813011426 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1033813011427 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1033813011428 SecA binding site; other site 1033813011429 Preprotein binding site; other site 1033813011430 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1033813011431 GSH binding site [chemical binding]; other site 1033813011432 catalytic residues [active] 1033813011433 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1033813011434 active site residue [active] 1033813011435 phosphoglyceromutase; Provisional; Region: PRK05434 1033813011436 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1033813011437 AmiB activator; Provisional; Region: PRK11637 1033813011438 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1033813011439 Peptidase family M23; Region: Peptidase_M23; pfam01551 1033813011440 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1033813011441 NodB motif; other site 1033813011442 putative active site [active] 1033813011443 putative catalytic site [active] 1033813011444 Zn binding site [ion binding]; other site 1033813011445 putative glycosyl transferase; Provisional; Region: PRK10073 1033813011446 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1033813011447 active site 1033813011448 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1033813011449 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1033813011450 NAD(P) binding site [chemical binding]; other site 1033813011451 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1033813011452 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1033813011453 substrate-cofactor binding pocket; other site 1033813011454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813011455 catalytic residue [active] 1033813011456 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1033813011457 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1033813011458 NADP binding site [chemical binding]; other site 1033813011459 homopentamer interface [polypeptide binding]; other site 1033813011460 substrate binding site [chemical binding]; other site 1033813011461 active site 1033813011462 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1033813011463 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1033813011464 putative active site [active] 1033813011465 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1033813011466 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1033813011467 putative active site [active] 1033813011468 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1033813011469 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1033813011470 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1033813011471 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1033813011472 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1033813011473 putative active site [active] 1033813011474 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 1033813011475 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1033813011476 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1033813011477 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1033813011478 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1033813011479 active site 1033813011480 (T/H)XGH motif; other site 1033813011481 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1033813011482 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1033813011483 DNA binding site [nucleotide binding] 1033813011484 catalytic residue [active] 1033813011485 H2TH interface [polypeptide binding]; other site 1033813011486 putative catalytic residues [active] 1033813011487 turnover-facilitating residue; other site 1033813011488 intercalation triad [nucleotide binding]; other site 1033813011489 8OG recognition residue [nucleotide binding]; other site 1033813011490 putative reading head residues; other site 1033813011491 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1033813011492 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1033813011493 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1033813011494 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1033813011495 hypothetical protein; Reviewed; Region: PRK00024 1033813011496 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1033813011497 MPN+ (JAMM) motif; other site 1033813011498 Zinc-binding site [ion binding]; other site 1033813011499 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1033813011500 Flavoprotein; Region: Flavoprotein; pfam02441 1033813011501 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1033813011502 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1033813011503 trimer interface [polypeptide binding]; other site 1033813011504 active site 1033813011505 division inhibitor protein; Provisional; Region: slmA; PRK09480 1033813011506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813011507 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033813011508 active site 1033813011509 ribonuclease PH; Reviewed; Region: rph; PRK00173 1033813011510 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1033813011511 hexamer interface [polypeptide binding]; other site 1033813011512 active site 1033813011513 hypothetical protein; Provisional; Region: PRK11820 1033813011514 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1033813011515 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1033813011516 Predicted membrane protein [Function unknown]; Region: COG2860 1033813011517 UPF0126 domain; Region: UPF0126; pfam03458 1033813011518 UPF0126 domain; Region: UPF0126; pfam03458 1033813011519 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1033813011520 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1033813011521 nucleotide binding pocket [chemical binding]; other site 1033813011522 K-X-D-G motif; other site 1033813011523 catalytic site [active] 1033813011524 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1033813011525 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1033813011526 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1033813011527 catalytic site [active] 1033813011528 G-X2-G-X-G-K; other site 1033813011529 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1033813011530 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1033813011531 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1033813011532 Zn2+ binding site [ion binding]; other site 1033813011533 Mg2+ binding site [ion binding]; other site 1033813011534 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1033813011535 synthetase active site [active] 1033813011536 NTP binding site [chemical binding]; other site 1033813011537 metal binding site [ion binding]; metal-binding site 1033813011538 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1033813011539 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1033813011540 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1033813011541 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1033813011542 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1033813011543 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1033813011544 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1033813011545 generic binding surface II; other site 1033813011546 ssDNA binding site; other site 1033813011547 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033813011548 ATP binding site [chemical binding]; other site 1033813011549 putative Mg++ binding site [ion binding]; other site 1033813011550 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813011551 nucleotide binding region [chemical binding]; other site 1033813011552 ATP-binding site [chemical binding]; other site 1033813011553 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1033813011554 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1033813011555 AsmA family; Region: AsmA; pfam05170 1033813011556 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1033813011557 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 1033813011558 fructokinase; Reviewed; Region: PRK09557 1033813011559 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033813011560 nucleotide binding site [chemical binding]; other site 1033813011561 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1033813011562 intersubunit interface [polypeptide binding]; other site 1033813011563 active site 1033813011564 zinc binding site [ion binding]; other site 1033813011565 Na+ binding site [ion binding]; other site 1033813011566 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1033813011567 intersubunit interface [polypeptide binding]; other site 1033813011568 active site 1033813011569 zinc binding site [ion binding]; other site 1033813011570 Na+ binding site [ion binding]; other site 1033813011571 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1033813011572 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1033813011573 active site 1033813011574 P-loop; other site 1033813011575 phosphorylation site [posttranslational modification] 1033813011576 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033813011577 active site 1033813011578 phosphorylation site [posttranslational modification] 1033813011579 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1033813011580 HTH domain; Region: HTH_11; pfam08279 1033813011581 Mga helix-turn-helix domain; Region: Mga; pfam05043 1033813011582 PRD domain; Region: PRD; pfam00874 1033813011583 PRD domain; Region: PRD; pfam00874 1033813011584 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1033813011585 active site 1033813011586 P-loop; other site 1033813011587 phosphorylation site [posttranslational modification] 1033813011588 putative alpha-glucosidase; Provisional; Region: PRK10658 1033813011589 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1033813011590 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1033813011591 active site 1033813011592 homotrimer interface [polypeptide binding]; other site 1033813011593 catalytic site [active] 1033813011594 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1033813011595 putative transporter; Provisional; Region: PRK11462 1033813011596 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1033813011597 Virulence protein [General function prediction only]; Region: COG3943 1033813011598 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1033813011599 EamA-like transporter family; Region: EamA; pfam00892 1033813011600 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1033813011601 EamA-like transporter family; Region: EamA; pfam00892 1033813011602 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1033813011603 lipoprotein, YaeC family; Region: TIGR00363 1033813011604 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1033813011605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813011606 putative substrate translocation pore; other site 1033813011607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 1033813011608 Predicted transcriptional regulator [Transcription]; Region: COG2944 1033813011609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813011610 non-specific DNA binding site [nucleotide binding]; other site 1033813011611 salt bridge; other site 1033813011612 sequence-specific DNA binding site [nucleotide binding]; other site 1033813011613 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1033813011614 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1033813011615 cryptic adenine deaminase; Provisional; Region: PRK10027 1033813011616 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1033813011617 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1033813011618 active site 1033813011619 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1033813011620 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1033813011621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813011622 putative substrate translocation pore; other site 1033813011623 regulatory protein UhpC; Provisional; Region: PRK11663 1033813011624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813011625 putative substrate translocation pore; other site 1033813011626 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1033813011627 MASE1; Region: MASE1; pfam05231 1033813011628 Histidine kinase; Region: HisKA_3; pfam07730 1033813011629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813011630 ATP binding site [chemical binding]; other site 1033813011631 Mg2+ binding site [ion binding]; other site 1033813011632 G-X-G motif; other site 1033813011633 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1033813011634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813011635 active site 1033813011636 phosphorylation site [posttranslational modification] 1033813011637 intermolecular recognition site; other site 1033813011638 dimerization interface [polypeptide binding]; other site 1033813011639 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813011640 DNA binding residues [nucleotide binding] 1033813011641 dimerization interface [polypeptide binding]; other site 1033813011642 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1033813011643 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1033813011644 putative valine binding site [chemical binding]; other site 1033813011645 dimer interface [polypeptide binding]; other site 1033813011646 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1033813011647 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1033813011648 PYR/PP interface [polypeptide binding]; other site 1033813011649 dimer interface [polypeptide binding]; other site 1033813011650 TPP binding site [chemical binding]; other site 1033813011651 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1033813011652 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1033813011653 TPP-binding site [chemical binding]; other site 1033813011654 dimer interface [polypeptide binding]; other site 1033813011655 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1033813011656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813011657 putative substrate translocation pore; other site 1033813011658 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1033813011659 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1033813011660 Predicted membrane protein [Function unknown]; Region: COG2149 1033813011661 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1033813011662 Sulfatase; Region: Sulfatase; pfam00884 1033813011663 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1033813011664 Sulfatase; Region: Sulfatase; cl17466 1033813011665 putative transporter; Provisional; Region: PRK10484 1033813011666 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 1033813011667 Na binding site [ion binding]; other site 1033813011668 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1033813011669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813011670 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1033813011671 putative transporter; Validated; Region: PRK03818 1033813011672 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1033813011673 TrkA-C domain; Region: TrkA_C; pfam02080 1033813011674 TrkA-C domain; Region: TrkA_C; pfam02080 1033813011675 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1033813011676 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1033813011677 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1033813011678 putative dimer interface [polypeptide binding]; other site 1033813011679 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1033813011680 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1033813011681 putative dimer interface [polypeptide binding]; other site 1033813011682 hypothetical protein; Provisional; Region: PRK11616 1033813011683 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1033813011684 putative oxidoreductase; Provisional; Region: PRK11445 1033813011685 hypothetical protein; Provisional; Region: PRK07236 1033813011686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813011687 D-galactonate transporter; Region: 2A0114; TIGR00893 1033813011688 putative substrate translocation pore; other site 1033813011689 galactonate dehydratase; Provisional; Region: PRK14017 1033813011690 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1033813011691 putative active site pocket [active] 1033813011692 putative metal binding site [ion binding]; other site 1033813011693 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1033813011694 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1033813011695 active site 1033813011696 intersubunit interface [polypeptide binding]; other site 1033813011697 catalytic residue [active] 1033813011698 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1033813011699 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1033813011700 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1033813011701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813011702 DNA-binding site [nucleotide binding]; DNA binding site 1033813011703 FCD domain; Region: FCD; pfam07729 1033813011704 hypothetical protein; Provisional; Region: PRK10215 1033813011705 sugar phosphate phosphatase; Provisional; Region: PRK10513 1033813011706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813011707 active site 1033813011708 motif I; other site 1033813011709 motif II; other site 1033813011710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813011711 hypothetical protein; Provisional; Region: PRK11426 1033813011712 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1033813011713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813011714 Mg2+ binding site [ion binding]; other site 1033813011715 G-X-G motif; other site 1033813011716 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1033813011717 anchoring element; other site 1033813011718 dimer interface [polypeptide binding]; other site 1033813011719 ATP binding site [chemical binding]; other site 1033813011720 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1033813011721 active site 1033813011722 putative metal-binding site [ion binding]; other site 1033813011723 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1033813011724 recF protein; Region: recf; TIGR00611 1033813011725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813011726 Walker A/P-loop; other site 1033813011727 ATP binding site [chemical binding]; other site 1033813011728 Q-loop/lid; other site 1033813011729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813011730 ABC transporter signature motif; other site 1033813011731 Walker B; other site 1033813011732 D-loop; other site 1033813011733 H-loop/switch region; other site 1033813011734 DNA polymerase III subunit beta; Validated; Region: PRK05643 1033813011735 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1033813011736 putative DNA binding surface [nucleotide binding]; other site 1033813011737 dimer interface [polypeptide binding]; other site 1033813011738 beta-clamp/clamp loader binding surface; other site 1033813011739 beta-clamp/translesion DNA polymerase binding surface; other site 1033813011740 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1033813011741 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1033813011742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813011743 Walker A motif; other site 1033813011744 ATP binding site [chemical binding]; other site 1033813011745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1033813011746 Walker B motif; other site 1033813011747 arginine finger; other site 1033813011748 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1033813011749 DnaA box-binding interface [nucleotide binding]; other site 1033813011750 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1033813011751 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1033813011752 membrane protein insertase; Provisional; Region: PRK01318 1033813011753 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1033813011754 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1033813011755 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1033813011756 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1033813011757 G1 box; other site 1033813011758 GTP/Mg2+ binding site [chemical binding]; other site 1033813011759 Switch I region; other site 1033813011760 G2 box; other site 1033813011761 Switch II region; other site 1033813011762 G3 box; other site 1033813011763 G4 box; other site 1033813011764 G5 box; other site 1033813011765 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1033813011766 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 1033813011767 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1033813011768 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1033813011769 catalytic residue [active] 1033813011770 tryptophan permease TnaB; Provisional; Region: PRK09664 1033813011771 aromatic amino acid transport protein; Region: araaP; TIGR00837 1033813011772 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1033813011773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813011774 putative substrate translocation pore; other site 1033813011775 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1033813011776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813011777 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1033813011778 substrate binding pocket [chemical binding]; other site 1033813011779 dimerization interface [polypeptide binding]; other site 1033813011780 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1033813011781 Predicted flavoprotein [General function prediction only]; Region: COG0431 1033813011782 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1033813011783 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1033813011784 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1033813011785 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813011786 motif II; other site 1033813011787 putative inner membrane protein; Provisional; Region: PRK09823 1033813011788 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 1033813011789 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1033813011790 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1033813011791 active site 1033813011792 trimer interface [polypeptide binding]; other site 1033813011793 allosteric site; other site 1033813011794 active site lid [active] 1033813011795 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 1033813011796 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1033813011797 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1033813011798 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1033813011799 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1033813011800 trimer interface; other site 1033813011801 sugar binding site [chemical binding]; other site 1033813011802 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1033813011803 beta-galactosidase; Region: BGL; TIGR03356 1033813011804 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 1033813011805 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1033813011806 active site turn [active] 1033813011807 phosphorylation site [posttranslational modification] 1033813011808 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1033813011809 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1033813011810 HPr interaction site; other site 1033813011811 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1033813011812 active site 1033813011813 phosphorylation site [posttranslational modification] 1033813011814 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1033813011815 PRD domain; Region: PRD; pfam00874 1033813011816 PRD domain; Region: PRD; pfam00874 1033813011817 transcriptional regulator PhoU; Provisional; Region: PRK11115 1033813011818 PhoU domain; Region: PhoU; pfam01895 1033813011819 PhoU domain; Region: PhoU; pfam01895 1033813011820 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1033813011821 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1033813011822 Walker A/P-loop; other site 1033813011823 ATP binding site [chemical binding]; other site 1033813011824 Q-loop/lid; other site 1033813011825 ABC transporter signature motif; other site 1033813011826 Walker B; other site 1033813011827 D-loop; other site 1033813011828 H-loop/switch region; other site 1033813011829 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1033813011830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813011831 dimer interface [polypeptide binding]; other site 1033813011832 conserved gate region; other site 1033813011833 putative PBP binding loops; other site 1033813011834 ABC-ATPase subunit interface; other site 1033813011835 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1033813011836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813011837 dimer interface [polypeptide binding]; other site 1033813011838 conserved gate region; other site 1033813011839 putative PBP binding loops; other site 1033813011840 ABC-ATPase subunit interface; other site 1033813011841 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813011842 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1033813011843 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1033813011844 glutaminase active site [active] 1033813011845 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1033813011846 dimer interface [polypeptide binding]; other site 1033813011847 active site 1033813011848 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1033813011849 dimer interface [polypeptide binding]; other site 1033813011850 active site 1033813011851 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1033813011852 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1033813011853 Substrate binding site; other site 1033813011854 Mg++ binding site; other site 1033813011855 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1033813011856 active site 1033813011857 substrate binding site [chemical binding]; other site 1033813011858 CoA binding site [chemical binding]; other site 1033813011859 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1033813011860 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1033813011861 gamma subunit interface [polypeptide binding]; other site 1033813011862 epsilon subunit interface [polypeptide binding]; other site 1033813011863 LBP interface [polypeptide binding]; other site 1033813011864 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1033813011865 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1033813011866 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1033813011867 alpha subunit interaction interface [polypeptide binding]; other site 1033813011868 Walker A motif; other site 1033813011869 ATP binding site [chemical binding]; other site 1033813011870 Walker B motif; other site 1033813011871 inhibitor binding site; inhibition site 1033813011872 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1033813011873 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1033813011874 core domain interface [polypeptide binding]; other site 1033813011875 delta subunit interface [polypeptide binding]; other site 1033813011876 epsilon subunit interface [polypeptide binding]; other site 1033813011877 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1033813011878 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1033813011879 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1033813011880 beta subunit interaction interface [polypeptide binding]; other site 1033813011881 Walker A motif; other site 1033813011882 ATP binding site [chemical binding]; other site 1033813011883 Walker B motif; other site 1033813011884 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1033813011885 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1033813011886 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1033813011887 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1033813011888 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1033813011889 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1033813011890 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1033813011891 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1033813011892 ATP synthase I chain; Region: ATP_synt_I; cl09170 1033813011893 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1033813011894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813011895 S-adenosylmethionine binding site [chemical binding]; other site 1033813011896 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1033813011897 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1033813011898 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1033813011899 FMN-binding protein MioC; Provisional; Region: PRK09004 1033813011900 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1033813011901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1033813011902 putative DNA binding site [nucleotide binding]; other site 1033813011903 putative Zn2+ binding site [ion binding]; other site 1033813011904 AsnC family; Region: AsnC_trans_reg; pfam01037 1033813011905 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1033813011906 dimer interface [polypeptide binding]; other site 1033813011907 active site 1033813011908 hypothetical protein; Provisional; Region: yieM; PRK10997 1033813011909 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1033813011910 metal ion-dependent adhesion site (MIDAS); other site 1033813011911 regulatory ATPase RavA; Provisional; Region: PRK13531 1033813011912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813011913 Walker A motif; other site 1033813011914 ATP binding site [chemical binding]; other site 1033813011915 Walker B motif; other site 1033813011916 arginine finger; other site 1033813011917 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1033813011918 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1033813011919 potassium uptake protein; Region: kup; TIGR00794 1033813011920 D-ribose pyranase; Provisional; Region: PRK11797 1033813011921 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1033813011922 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1033813011923 Walker A/P-loop; other site 1033813011924 ATP binding site [chemical binding]; other site 1033813011925 Q-loop/lid; other site 1033813011926 ABC transporter signature motif; other site 1033813011927 Walker B; other site 1033813011928 D-loop; other site 1033813011929 H-loop/switch region; other site 1033813011930 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1033813011931 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033813011932 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1033813011933 TM-ABC transporter signature motif; other site 1033813011934 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1033813011935 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1033813011936 ligand binding site [chemical binding]; other site 1033813011937 dimerization interface [polypeptide binding]; other site 1033813011938 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1033813011939 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1033813011940 substrate binding site [chemical binding]; other site 1033813011941 dimer interface [polypeptide binding]; other site 1033813011942 ATP binding site [chemical binding]; other site 1033813011943 transcriptional repressor RbsR; Provisional; Region: PRK10423 1033813011944 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813011945 DNA binding site [nucleotide binding] 1033813011946 domain linker motif; other site 1033813011947 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1033813011948 dimerization interface [polypeptide binding]; other site 1033813011949 ligand binding site [chemical binding]; other site 1033813011950 putative transporter; Provisional; Region: PRK10504 1033813011951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813011952 putative substrate translocation pore; other site 1033813011953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813011954 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1033813011955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813011956 DNA-binding site [nucleotide binding]; DNA binding site 1033813011957 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1033813011958 transcriptional regulator HdfR; Provisional; Region: PRK03601 1033813011959 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813011960 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1033813011961 dimerization interface [polypeptide binding]; other site 1033813011962 hypothetical protein; Provisional; Region: PRK11027 1033813011963 putative ATP-dependent protease; Provisional; Region: PRK09862 1033813011964 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1033813011965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813011966 Walker A motif; other site 1033813011967 ATP binding site [chemical binding]; other site 1033813011968 Walker B motif; other site 1033813011969 arginine finger; other site 1033813011970 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1033813011971 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1033813011972 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1033813011973 PYR/PP interface [polypeptide binding]; other site 1033813011974 dimer interface [polypeptide binding]; other site 1033813011975 TPP binding site [chemical binding]; other site 1033813011976 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1033813011977 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1033813011978 TPP-binding site [chemical binding]; other site 1033813011979 dimer interface [polypeptide binding]; other site 1033813011980 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1033813011981 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1033813011982 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1033813011983 homodimer interface [polypeptide binding]; other site 1033813011984 substrate-cofactor binding pocket; other site 1033813011985 catalytic residue [active] 1033813011986 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1033813011987 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1033813011988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813011989 catalytic residue [active] 1033813011990 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1033813011991 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1033813011992 putative Ile/Val binding site [chemical binding]; other site 1033813011993 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1033813011994 putative Ile/Val binding site [chemical binding]; other site 1033813011995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813011996 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1033813011997 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1033813011998 putative dimerization interface [polypeptide binding]; other site 1033813011999 ketol-acid reductoisomerase; Validated; Region: PRK05225 1033813012000 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1033813012001 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1033813012002 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1033813012003 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1033813012004 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1033813012005 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1033813012006 Part of AAA domain; Region: AAA_19; pfam13245 1033813012007 Family description; Region: UvrD_C_2; pfam13538 1033813012008 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1033813012009 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1033813012010 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1033813012011 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1033813012012 ATP binding site [chemical binding]; other site 1033813012013 Mg++ binding site [ion binding]; other site 1033813012014 motif III; other site 1033813012015 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813012016 nucleotide binding region [chemical binding]; other site 1033813012017 ATP-binding site [chemical binding]; other site 1033813012018 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1033813012019 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1033813012020 catalytic residues [active] 1033813012021 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1033813012022 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1033813012023 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1033813012024 RNA binding site [nucleotide binding]; other site 1033813012025 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1033813012026 multimer interface [polypeptide binding]; other site 1033813012027 Walker A motif; other site 1033813012028 ATP binding site [chemical binding]; other site 1033813012029 Walker B motif; other site 1033813012030 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1033813012031 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1033813012032 Mg++ binding site [ion binding]; other site 1033813012033 putative catalytic motif [active] 1033813012034 substrate binding site [chemical binding]; other site 1033813012035 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1033813012036 Chain length determinant protein; Region: Wzz; pfam02706 1033813012037 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1033813012038 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1033813012039 active site 1033813012040 homodimer interface [polypeptide binding]; other site 1033813012041 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1033813012042 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1033813012043 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1033813012044 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1033813012045 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1033813012046 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1033813012047 NAD binding site [chemical binding]; other site 1033813012048 substrate binding site [chemical binding]; other site 1033813012049 homodimer interface [polypeptide binding]; other site 1033813012050 active site 1033813012051 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1033813012052 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1033813012053 substrate binding site; other site 1033813012054 tetramer interface; other site 1033813012055 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1033813012056 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1033813012057 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1033813012058 inhibitor-cofactor binding pocket; inhibition site 1033813012059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813012060 catalytic residue [active] 1033813012061 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1033813012062 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1033813012063 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1033813012064 putative common antigen polymerase; Provisional; Region: PRK02975 1033813012065 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1033813012066 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1033813012067 putative transport protein YifK; Provisional; Region: PRK10746 1033813012068 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1033813012069 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813012070 FeS/SAM binding site; other site 1033813012071 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1033813012072 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1033813012073 Sulfatase; Region: Sulfatase; pfam00884 1033813012074 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1033813012075 HemY protein N-terminus; Region: HemY_N; pfam07219 1033813012076 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1033813012077 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1033813012078 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1033813012079 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1033813012080 active site 1033813012081 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1033813012082 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1033813012083 domain interfaces; other site 1033813012084 active site 1033813012085 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1033813012086 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1033813012087 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1033813012088 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1033813012089 putative iron binding site [ion binding]; other site 1033813012090 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1033813012091 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1033813012092 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1033813012093 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1033813012094 hypothetical protein; Provisional; Region: PRK10963 1033813012095 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1033813012096 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033813012097 active site 1033813012098 DNA binding site [nucleotide binding] 1033813012099 Int/Topo IB signature motif; other site 1033813012100 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1033813012101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813012102 motif II; other site 1033813012103 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1033813012104 Part of AAA domain; Region: AAA_19; pfam13245 1033813012105 Family description; Region: UvrD_C_2; pfam13538 1033813012106 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1033813012107 Predicted periplasmic protein [Function unknown]; Region: COG3698 1033813012108 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1033813012109 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1033813012110 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085 1033813012111 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1033813012112 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1033813012113 GTP binding site; other site 1033813012114 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1033813012115 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1033813012116 serine/threonine protein kinase; Provisional; Region: PRK11768 1033813012117 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1033813012118 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1033813012119 catalytic residues [active] 1033813012120 hinge region; other site 1033813012121 alpha helical domain; other site 1033813012122 potential frameshift: common BLAST hit: gi|384545462|ref|YP_005729526.1| putative GTP-binding protein 1033813012123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1033813012124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1033813012125 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1033813012126 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1033813012127 putative acyl-acceptor binding pocket; other site 1033813012128 DNA polymerase I; Provisional; Region: PRK05755 1033813012129 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1033813012130 active site 1033813012131 metal binding site 1 [ion binding]; metal-binding site 1033813012132 putative 5' ssDNA interaction site; other site 1033813012133 metal binding site 3; metal-binding site 1033813012134 metal binding site 2 [ion binding]; metal-binding site 1033813012135 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1033813012136 putative DNA binding site [nucleotide binding]; other site 1033813012137 putative metal binding site [ion binding]; other site 1033813012138 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1033813012139 active site 1033813012140 catalytic site [active] 1033813012141 substrate binding site [chemical binding]; other site 1033813012142 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1033813012143 active site 1033813012144 DNA binding site [nucleotide binding] 1033813012145 catalytic site [active] 1033813012146 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1033813012147 G1 box; other site 1033813012148 GTP/Mg2+ binding site [chemical binding]; other site 1033813012149 Switch I region; other site 1033813012150 G2 box; other site 1033813012151 G3 box; other site 1033813012152 Switch II region; other site 1033813012153 G4 box; other site 1033813012154 G5 box; other site 1033813012155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 1033813012156 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1033813012157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813012158 FeS/SAM binding site; other site 1033813012159 HemN C-terminal domain; Region: HemN_C; pfam06969 1033813012160 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1033813012161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813012162 active site 1033813012163 phosphorylation site [posttranslational modification] 1033813012164 intermolecular recognition site; other site 1033813012165 dimerization interface [polypeptide binding]; other site 1033813012166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813012167 Walker A motif; other site 1033813012168 ATP binding site [chemical binding]; other site 1033813012169 Walker B motif; other site 1033813012170 arginine finger; other site 1033813012171 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1033813012172 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1033813012173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033813012174 putative active site [active] 1033813012175 heme pocket [chemical binding]; other site 1033813012176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813012177 dimer interface [polypeptide binding]; other site 1033813012178 phosphorylation site [posttranslational modification] 1033813012179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813012180 ATP binding site [chemical binding]; other site 1033813012181 Mg2+ binding site [ion binding]; other site 1033813012182 G-X-G motif; other site 1033813012183 glutamine synthetase; Provisional; Region: glnA; PRK09469 1033813012184 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1033813012185 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1033813012186 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1033813012187 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1033813012188 G1 box; other site 1033813012189 putative GEF interaction site [polypeptide binding]; other site 1033813012190 GTP/Mg2+ binding site [chemical binding]; other site 1033813012191 Switch I region; other site 1033813012192 G2 box; other site 1033813012193 G3 box; other site 1033813012194 Switch II region; other site 1033813012195 G4 box; other site 1033813012196 G5 box; other site 1033813012197 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1033813012198 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1033813012199 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1033813012200 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1033813012201 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813012202 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1033813012203 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1033813012204 substrate binding site [chemical binding]; other site 1033813012205 ATP binding site [chemical binding]; other site 1033813012206 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1033813012207 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1033813012208 Class I aldolases; Region: Aldolase_Class_I; cl17187 1033813012209 catalytic residue [active] 1033813012210 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1033813012211 putative oxidoreductase; Provisional; Region: PRK10083 1033813012212 NAD(P) binding site [chemical binding]; other site 1033813012213 benzoate transport; Region: 2A0115; TIGR00895 1033813012214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813012215 shikimate transporter; Provisional; Region: PRK09952 1033813012216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813012217 putative substrate translocation pore; other site 1033813012218 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1033813012219 active site 1033813012220 catalytic residues [active] 1033813012221 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1033813012222 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813012223 motif II; other site 1033813012224 hypothetical protein; Reviewed; Region: PRK01637 1033813012225 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1033813012226 putative active site [active] 1033813012227 dimerization interface [polypeptide binding]; other site 1033813012228 putative tRNAtyr binding site [nucleotide binding]; other site 1033813012229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813012230 Coenzyme A binding pocket [chemical binding]; other site 1033813012231 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1033813012232 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1033813012233 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1033813012234 substrate binding pocket [chemical binding]; other site 1033813012235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813012236 non-specific DNA binding site [nucleotide binding]; other site 1033813012237 salt bridge; other site 1033813012238 sequence-specific DNA binding site [nucleotide binding]; other site 1033813012239 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1033813012240 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1033813012241 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1033813012242 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1033813012243 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1033813012244 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1033813012245 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1033813012246 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813012247 molybdopterin cofactor binding site; other site 1033813012248 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1033813012249 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1033813012250 molybdopterin cofactor binding site; other site 1033813012251 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813012252 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1033813012253 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1033813012254 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1033813012255 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1033813012256 intersubunit interface [polypeptide binding]; other site 1033813012257 active site 1033813012258 Zn2+ binding site [ion binding]; other site 1033813012259 L-rhamnose isomerase; Provisional; Region: PRK01076 1033813012260 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1033813012261 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1033813012262 N- and C-terminal domain interface [polypeptide binding]; other site 1033813012263 active site 1033813012264 putative catalytic site [active] 1033813012265 metal binding site [ion binding]; metal-binding site 1033813012266 ATP binding site [chemical binding]; other site 1033813012267 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1033813012268 carbohydrate binding site [chemical binding]; other site 1033813012269 transcriptional activator RhaS; Provisional; Region: PRK13503 1033813012270 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1033813012271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813012272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813012273 transcriptional activator RhaR; Provisional; Region: PRK13500 1033813012274 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1033813012275 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813012276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813012277 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1033813012278 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1033813012279 superoxide dismutase; Provisional; Region: PRK10925 1033813012280 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1033813012281 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1033813012282 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 1033813012283 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1033813012284 MOSC domain; Region: MOSC; pfam03473 1033813012285 3-alpha domain; Region: 3-alpha; pfam03475 1033813012286 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1033813012287 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033813012288 dimerization interface [polypeptide binding]; other site 1033813012289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813012290 dimer interface [polypeptide binding]; other site 1033813012291 phosphorylation site [posttranslational modification] 1033813012292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813012293 ATP binding site [chemical binding]; other site 1033813012294 Mg2+ binding site [ion binding]; other site 1033813012295 G-X-G motif; other site 1033813012296 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1033813012297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813012298 intermolecular recognition site; other site 1033813012299 active site 1033813012300 dimerization interface [polypeptide binding]; other site 1033813012301 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813012302 DNA binding site [nucleotide binding] 1033813012303 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1033813012304 dimer interface [polypeptide binding]; other site 1033813012305 integrase; Provisional; Region: int; PHA02601 1033813012306 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033813012307 active site 1033813012308 DNA binding site [nucleotide binding] 1033813012309 Int/Topo IB signature motif; other site 1033813012310 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 1033813012311 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1033813012312 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1033813012313 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1033813012314 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1033813012315 portal vertex protein; Provisional; Region: Q; PHA02536 1033813012316 Phage portal protein; Region: Phage_portal; pfam04860 1033813012317 terminase ATPase subunit; Provisional; Region: P; PHA02535 1033813012318 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1033813012319 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 1033813012320 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 1033813012321 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1033813012322 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1033813012323 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1033813012324 Phage holin family 2; Region: Phage_holin_2; pfam04550 1033813012325 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 1033813012326 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1033813012327 catalytic residue [active] 1033813012328 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1033813012329 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1033813012330 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1033813012331 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1033813012332 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1033813012333 baseplate wedge subunit; Provisional; Region: W; PHA02516 1033813012334 baseplate assembly protein; Provisional; Region: J; PHA02568 1033813012335 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 1033813012336 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1033813012337 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1033813012338 Phage Tail Collar Domain; Region: Collar; pfam07484 1033813012339 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1033813012340 major tail sheath protein; Provisional; Region: FI; PHA02560 1033813012341 major tail tube protein; Provisional; Region: FII; PHA02600 1033813012342 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1033813012343 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1033813012344 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1033813012345 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1033813012346 tail protein; Provisional; Region: D; PHA02561 1033813012347 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 1033813012348 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1033813012349 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1033813012350 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1033813012351 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1033813012352 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1033813012353 active site 1033813012354 ADP/pyrophosphate binding site [chemical binding]; other site 1033813012355 dimerization interface [polypeptide binding]; other site 1033813012356 allosteric effector site; other site 1033813012357 fructose-1,6-bisphosphate binding site; other site 1033813012358 sulfate transporter subunit; Provisional; Region: PRK10752 1033813012359 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1033813012360 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 1033813012361 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1033813012362 triosephosphate isomerase; Provisional; Region: PRK14567 1033813012363 substrate binding site [chemical binding]; other site 1033813012364 dimer interface [polypeptide binding]; other site 1033813012365 catalytic triad [active] 1033813012366 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1033813012367 Predicted membrane protein [Function unknown]; Region: COG3152 1033813012368 hypothetical protein; Provisional; Region: PRK09981 1033813012369 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1033813012370 Ligand Binding Site [chemical binding]; other site 1033813012371 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1033813012372 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1033813012373 FAD binding pocket [chemical binding]; other site 1033813012374 FAD binding motif [chemical binding]; other site 1033813012375 phosphate binding motif [ion binding]; other site 1033813012376 beta-alpha-beta structure motif; other site 1033813012377 NAD binding pocket [chemical binding]; other site 1033813012378 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1033813012379 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1033813012380 putative active site [active] 1033813012381 glycerol kinase; Provisional; Region: glpK; PRK00047 1033813012382 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1033813012383 N- and C-terminal domain interface [polypeptide binding]; other site 1033813012384 active site 1033813012385 MgATP binding site [chemical binding]; other site 1033813012386 catalytic site [active] 1033813012387 metal binding site [ion binding]; metal-binding site 1033813012388 glycerol binding site [chemical binding]; other site 1033813012389 homotetramer interface [polypeptide binding]; other site 1033813012390 homodimer interface [polypeptide binding]; other site 1033813012391 FBP binding site [chemical binding]; other site 1033813012392 protein IIAGlc interface [polypeptide binding]; other site 1033813012393 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1033813012394 amphipathic channel; other site 1033813012395 Asn-Pro-Ala signature motifs; other site 1033813012396 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1033813012397 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1033813012398 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1033813012399 UbiA prenyltransferase family; Region: UbiA; pfam01040 1033813012400 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1033813012401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813012402 Walker A motif; other site 1033813012403 ATP binding site [chemical binding]; other site 1033813012404 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1033813012405 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1033813012406 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1033813012407 active site 1033813012408 HslU subunit interaction site [polypeptide binding]; other site 1033813012409 essential cell division protein FtsN; Provisional; Region: PRK10927 1033813012410 cell division protein FtsN; Provisional; Region: PRK12757 1033813012411 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813012412 DNA binding site [nucleotide binding] 1033813012413 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1033813012414 domain linker motif; other site 1033813012415 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1033813012416 dimerization interface [polypeptide binding]; other site 1033813012417 ligand binding site [chemical binding]; other site 1033813012418 primosome assembly protein PriA; Validated; Region: PRK05580 1033813012419 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033813012420 ATP binding site [chemical binding]; other site 1033813012421 putative Mg++ binding site [ion binding]; other site 1033813012422 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1033813012423 ATP-binding site [chemical binding]; other site 1033813012424 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1033813012425 hypothetical protein; Provisional; Region: PRK10030 1033813012426 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1033813012427 dimerization interface [polypeptide binding]; other site 1033813012428 DNA binding site [nucleotide binding] 1033813012429 corepressor binding sites; other site 1033813012430 cystathionine gamma-synthase; Provisional; Region: PRK08045 1033813012431 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1033813012432 homodimer interface [polypeptide binding]; other site 1033813012433 substrate-cofactor binding pocket; other site 1033813012434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813012435 catalytic residue [active] 1033813012436 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1033813012437 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1033813012438 putative catalytic residues [active] 1033813012439 putative nucleotide binding site [chemical binding]; other site 1033813012440 putative aspartate binding site [chemical binding]; other site 1033813012441 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1033813012442 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1033813012443 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1033813012444 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1033813012445 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1033813012446 active site 1033813012447 metal binding site [ion binding]; metal-binding site 1033813012448 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1033813012449 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1033813012450 FAD binding site [chemical binding]; other site 1033813012451 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1033813012452 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1033813012453 heme binding site [chemical binding]; other site 1033813012454 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1033813012455 EamA-like transporter family; Region: EamA; pfam00892 1033813012456 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1033813012457 EamA-like transporter family; Region: EamA; pfam00892 1033813012458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 1033813012459 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1033813012460 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1033813012461 dimer interface [polypeptide binding]; other site 1033813012462 active site 1033813012463 metal binding site [ion binding]; metal-binding site 1033813012464 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1033813012465 active site 1033813012466 intersubunit interactions; other site 1033813012467 catalytic residue [active] 1033813012468 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1033813012469 dimerization domain swap beta strand [polypeptide binding]; other site 1033813012470 regulatory protein interface [polypeptide binding]; other site 1033813012471 active site 1033813012472 regulatory phosphorylation site [posttranslational modification]; other site 1033813012473 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1033813012474 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1033813012475 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1033813012476 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1033813012477 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033813012478 active site 1033813012479 phosphorylation site [posttranslational modification] 1033813012480 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 1033813012481 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1033813012482 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1033813012483 active site 1033813012484 P-loop; other site 1033813012485 phosphorylation site [posttranslational modification] 1033813012486 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 1033813012487 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1033813012488 dimer interface [polypeptide binding]; other site 1033813012489 active site 1033813012490 glycine loop; other site 1033813012491 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1033813012492 FeS/SAM binding site; other site 1033813012493 pyruvate formate lyase II activase; Provisional; Region: PRK10076 1033813012494 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1033813012495 active site 1033813012496 P-loop; other site 1033813012497 phosphorylation site [posttranslational modification] 1033813012498 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1033813012499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813012500 hypothetical protein; Provisional; Region: PRK10649 1033813012501 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1033813012502 Sulfatase; Region: Sulfatase; pfam00884 1033813012503 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1033813012504 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1033813012505 acetylornithine deacetylase; Provisional; Region: PRK05111 1033813012506 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1033813012507 metal binding site [ion binding]; metal-binding site 1033813012508 putative dimer interface [polypeptide binding]; other site 1033813012509 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1033813012510 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1033813012511 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1033813012512 nucleotide binding site [chemical binding]; other site 1033813012513 N-acetyl-L-glutamate binding site [chemical binding]; other site 1033813012514 argininosuccinate lyase; Provisional; Region: PRK04833 1033813012515 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1033813012516 active sites [active] 1033813012517 tetramer interface [polypeptide binding]; other site 1033813012518 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1033813012519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813012520 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1033813012521 dimerization interface [polypeptide binding]; other site 1033813012522 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1033813012523 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813012524 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1033813012525 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1033813012526 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1033813012527 metal binding site [ion binding]; metal-binding site 1033813012528 putative dimer interface [polypeptide binding]; other site 1033813012529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813012530 metabolite-proton symporter; Region: 2A0106; TIGR00883 1033813012531 putative substrate translocation pore; other site 1033813012532 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1033813012533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813012534 hypothetical protein; Provisional; Region: PRK11056 1033813012535 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1033813012536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813012537 S-adenosylmethionine binding site [chemical binding]; other site 1033813012538 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1033813012539 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813012540 N-terminal plug; other site 1033813012541 ligand-binding site [chemical binding]; other site 1033813012542 glutamate racemase; Provisional; Region: PRK00865 1033813012543 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1033813012544 EamA-like transporter family; Region: EamA; cl17759 1033813012545 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1033813012546 CoenzymeA binding site [chemical binding]; other site 1033813012547 subunit interaction site [polypeptide binding]; other site 1033813012548 PHB binding site; other site 1033813012549 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1033813012550 dimerization interface [polypeptide binding]; other site 1033813012551 substrate binding site [chemical binding]; other site 1033813012552 active site 1033813012553 calcium binding site [ion binding]; other site 1033813012554 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1033813012555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033813012556 ATP binding site [chemical binding]; other site 1033813012557 putative Mg++ binding site [ion binding]; other site 1033813012558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033813012559 nucleotide binding region [chemical binding]; other site 1033813012560 ATP-binding site [chemical binding]; other site 1033813012561 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1033813012562 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1033813012563 threonine efflux system; Provisional; Region: PRK10229 1033813012564 putative transposase; Provisional; Region: PRK09857 1033813012565 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1033813012566 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1033813012567 lysophospholipase L2; Provisional; Region: PRK10749 1033813012568 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1033813012569 putative hydrolase; Provisional; Region: PRK10976 1033813012570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813012571 active site 1033813012572 motif I; other site 1033813012573 motif II; other site 1033813012574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813012575 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1033813012576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813012577 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1033813012578 putative dimerization interface [polypeptide binding]; other site 1033813012579 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1033813012580 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1033813012581 THF binding site; other site 1033813012582 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1033813012583 substrate binding site [chemical binding]; other site 1033813012584 THF binding site; other site 1033813012585 zinc-binding site [ion binding]; other site 1033813012586 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1033813012587 tetramer interface [polypeptide binding]; other site 1033813012588 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1033813012589 active site 1033813012590 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1033813012591 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1033813012592 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1033813012593 active site turn [active] 1033813012594 phosphorylation site [posttranslational modification] 1033813012595 transketolase; Reviewed; Region: PRK12753 1033813012596 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1033813012597 TPP-binding site [chemical binding]; other site 1033813012598 dimer interface [polypeptide binding]; other site 1033813012599 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1033813012600 PYR/PP interface [polypeptide binding]; other site 1033813012601 dimer interface [polypeptide binding]; other site 1033813012602 TPP binding site [chemical binding]; other site 1033813012603 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1033813012604 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1033813012605 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1033813012606 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1033813012607 putative active site [active] 1033813012608 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1033813012609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813012610 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1033813012611 dimerization interface [polypeptide binding]; other site 1033813012612 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1033813012613 Na binding site [ion binding]; other site 1033813012614 allophanate hydrolase; Provisional; Region: PRK08186 1033813012615 carbamate kinase; Reviewed; Region: PRK12686 1033813012616 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1033813012617 putative substrate binding site [chemical binding]; other site 1033813012618 nucleotide binding site [chemical binding]; other site 1033813012619 nucleotide binding site [chemical binding]; other site 1033813012620 homodimer interface [polypeptide binding]; other site 1033813012621 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1033813012622 CoA binding domain; Region: CoA_binding; pfam02629 1033813012623 CoA-ligase; Region: Ligase_CoA; pfam00549 1033813012624 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1033813012625 Isochorismatase family; Region: Isochorismatase; pfam00857 1033813012626 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1033813012627 catalytic triad [active] 1033813012628 conserved cis-peptide bond; other site 1033813012629 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1033813012630 uridine phosphorylase; Provisional; Region: PRK11178 1033813012631 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1033813012632 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1033813012633 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1033813012634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1033813012635 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1033813012636 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1033813012637 active site 1033813012638 intersubunit interface [polypeptide binding]; other site 1033813012639 catalytic residue [active] 1033813012640 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1033813012641 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1033813012642 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1033813012643 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1033813012644 Bacterial transcriptional regulator; Region: IclR; pfam01614 1033813012645 DNA recombination protein RmuC; Provisional; Region: PRK10361 1033813012646 RmuC family; Region: RmuC; pfam02646 1033813012647 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1033813012648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813012649 S-adenosylmethionine binding site [chemical binding]; other site 1033813012650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1033813012651 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1033813012652 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1033813012653 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1033813012654 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1033813012655 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1033813012656 sec-independent translocase; Provisional; Region: PRK01770 1033813012657 sec-independent translocase; Provisional; Region: tatB; PRK00404 1033813012658 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1033813012659 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1033813012660 active site 1033813012661 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1033813012662 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1033813012663 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1033813012664 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1033813012665 FMN reductase; Validated; Region: fre; PRK08051 1033813012666 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1033813012667 FAD binding pocket [chemical binding]; other site 1033813012668 FAD binding motif [chemical binding]; other site 1033813012669 phosphate binding motif [ion binding]; other site 1033813012670 beta-alpha-beta structure motif; other site 1033813012671 NAD binding pocket [chemical binding]; other site 1033813012672 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1033813012673 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1033813012674 dimer interface [polypeptide binding]; other site 1033813012675 active site 1033813012676 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1033813012677 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1033813012678 substrate binding site [chemical binding]; other site 1033813012679 oxyanion hole (OAH) forming residues; other site 1033813012680 trimer interface [polypeptide binding]; other site 1033813012681 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1033813012682 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1033813012683 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1033813012684 proline dipeptidase; Provisional; Region: PRK13607 1033813012685 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1033813012686 active site 1033813012687 hypothetical protein; Provisional; Region: PRK11568 1033813012688 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1033813012689 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1033813012690 potassium transporter; Provisional; Region: PRK10750 1033813012691 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1033813012692 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1033813012693 hypothetical protein; Provisional; Region: PRK10039 1033813012694 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1033813012695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813012696 Coenzyme A binding pocket [chemical binding]; other site 1033813012697 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1033813012698 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1033813012699 proposed active site lysine [active] 1033813012700 conserved cys residue [active] 1033813012701 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1033813012702 malate synthase A; Region: malate_syn_A; TIGR01344 1033813012703 active site 1033813012704 isocitrate lyase; Provisional; Region: PRK15063 1033813012705 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1033813012706 tetramer interface [polypeptide binding]; other site 1033813012707 active site 1033813012708 Mg2+/Mn2+ binding site [ion binding]; other site 1033813012709 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1033813012710 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1033813012711 transcriptional repressor IclR; Provisional; Region: PRK11569 1033813012712 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1033813012713 Bacterial transcriptional regulator; Region: IclR; pfam01614 1033813012714 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1033813012715 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1033813012716 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1033813012717 substrate binding pocket [chemical binding]; other site 1033813012718 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1033813012719 B12 binding site [chemical binding]; other site 1033813012720 cobalt ligand [ion binding]; other site 1033813012721 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1033813012722 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1033813012723 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1033813012724 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1033813012725 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1033813012726 active site pocket [active] 1033813012727 oxyanion hole [active] 1033813012728 catalytic triad [active] 1033813012729 active site nucleophile [active] 1033813012730 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1033813012731 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1033813012732 putative NAD(P) binding site [chemical binding]; other site 1033813012733 catalytic Zn binding site [ion binding]; other site 1033813012734 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 1033813012735 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1033813012736 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1033813012737 active site 1033813012738 phosphorylation site [posttranslational modification] 1033813012739 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1033813012740 active pocket/dimerization site; other site 1033813012741 active site 1033813012742 phosphorylation site [posttranslational modification] 1033813012743 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 1033813012744 classical (c) SDRs; Region: SDR_c; cd05233 1033813012745 NAD(P) binding site [chemical binding]; other site 1033813012746 active site 1033813012747 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1033813012748 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1033813012749 putative DNA binding site [nucleotide binding]; other site 1033813012750 putative Zn2+ binding site [ion binding]; other site 1033813012751 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1033813012752 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1033813012753 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033813012754 RNA binding surface [nucleotide binding]; other site 1033813012755 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1033813012756 probable active site [active] 1033813012757 hypothetical protein; Provisional; Region: PRK10515 1033813012758 aspartate kinase III; Validated; Region: PRK09084 1033813012759 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1033813012760 nucleotide binding site [chemical binding]; other site 1033813012761 substrate binding site [chemical binding]; other site 1033813012762 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 1033813012763 lysine allosteric regulatory site; other site 1033813012764 dimer interface [polypeptide binding]; other site 1033813012765 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1033813012766 dimer interface [polypeptide binding]; other site 1033813012767 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1033813012768 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1033813012769 active site 1033813012770 dimer interface [polypeptide binding]; other site 1033813012771 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1033813012772 dimer interface [polypeptide binding]; other site 1033813012773 active site 1033813012774 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1033813012775 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1033813012776 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1033813012777 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1033813012778 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1033813012779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813012780 dimer interface [polypeptide binding]; other site 1033813012781 conserved gate region; other site 1033813012782 putative PBP binding loops; other site 1033813012783 ABC-ATPase subunit interface; other site 1033813012784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813012785 dimer interface [polypeptide binding]; other site 1033813012786 conserved gate region; other site 1033813012787 putative PBP binding loops; other site 1033813012788 ABC-ATPase subunit interface; other site 1033813012789 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1033813012790 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1033813012791 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1033813012792 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1033813012793 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1033813012794 Walker A/P-loop; other site 1033813012795 ATP binding site [chemical binding]; other site 1033813012796 Q-loop/lid; other site 1033813012797 ABC transporter signature motif; other site 1033813012798 Walker B; other site 1033813012799 D-loop; other site 1033813012800 H-loop/switch region; other site 1033813012801 TOBE domain; Region: TOBE_2; pfam08402 1033813012802 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1033813012803 trimer interface; other site 1033813012804 sugar binding site [chemical binding]; other site 1033813012805 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1033813012806 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1033813012807 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1033813012808 UbiA prenyltransferase family; Region: UbiA; pfam01040 1033813012809 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1033813012810 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1033813012811 putative acyl-acceptor binding pocket; other site 1033813012812 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1033813012813 LexA repressor; Validated; Region: PRK00215 1033813012814 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1033813012815 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1033813012816 Catalytic site [active] 1033813012817 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1033813012818 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1033813012819 hypothetical protein; Provisional; Region: PRK10428 1033813012820 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1033813012821 metal binding site 2 [ion binding]; metal-binding site 1033813012822 putative DNA binding helix; other site 1033813012823 metal binding site 1 [ion binding]; metal-binding site 1033813012824 dimer interface [polypeptide binding]; other site 1033813012825 structural Zn2+ binding site [ion binding]; other site 1033813012826 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1033813012827 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1033813012828 FMN binding site [chemical binding]; other site 1033813012829 active site 1033813012830 catalytic residues [active] 1033813012831 substrate binding site [chemical binding]; other site 1033813012832 phage shock protein G; Reviewed; Region: pspG; PRK09459 1033813012833 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1033813012834 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1033813012835 NADP binding site [chemical binding]; other site 1033813012836 dimer interface [polypeptide binding]; other site 1033813012837 L-aspartate oxidase; Provisional; Region: PRK06175 1033813012838 FAD binding domain; Region: FAD_binding_2; pfam00890 1033813012839 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1033813012840 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1033813012841 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1033813012842 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1033813012843 substrate binding site [chemical binding]; other site 1033813012844 oxyanion hole (OAH) forming residues; other site 1033813012845 trimer interface [polypeptide binding]; other site 1033813012846 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1033813012847 Coenzyme A transferase; Region: CoA_trans; smart00882 1033813012848 Coenzyme A transferase; Region: CoA_trans; cl17247 1033813012849 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1033813012850 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813012851 DNA binding site [nucleotide binding] 1033813012852 domain linker motif; other site 1033813012853 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1033813012854 putative dimerization interface [polypeptide binding]; other site 1033813012855 putative ligand binding site [chemical binding]; other site 1033813012856 replicative DNA helicase; Provisional; Region: PRK08006 1033813012857 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1033813012858 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1033813012859 Walker A motif; other site 1033813012860 ATP binding site [chemical binding]; other site 1033813012861 Walker B motif; other site 1033813012862 DNA binding loops [nucleotide binding] 1033813012863 alanine racemase; Reviewed; Region: alr; PRK00053 1033813012864 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1033813012865 active site 1033813012866 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1033813012867 substrate binding site [chemical binding]; other site 1033813012868 catalytic residues [active] 1033813012869 dimer interface [polypeptide binding]; other site 1033813012870 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1033813012871 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1033813012872 active site 1033813012873 nucleotide binding site [chemical binding]; other site 1033813012874 HIGH motif; other site 1033813012875 KMSKS motif; other site 1033813012876 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1033813012877 AAA domain; Region: AAA_28; pfam13521 1033813012878 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1033813012879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1033813012880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813012881 homodimer interface [polypeptide binding]; other site 1033813012882 catalytic residue [active] 1033813012883 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1033813012884 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1033813012885 TPP-binding site [chemical binding]; other site 1033813012886 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1033813012887 dimer interface [polypeptide binding]; other site 1033813012888 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1033813012889 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1033813012890 E3 interaction surface; other site 1033813012891 lipoyl attachment site [posttranslational modification]; other site 1033813012892 e3 binding domain; Region: E3_binding; pfam02817 1033813012893 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1033813012894 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1033813012895 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1033813012896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033813012897 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1033813012898 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1033813012899 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1033813012900 CoA-ligase; Region: Ligase_CoA; pfam00549 1033813012901 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1033813012902 CoA binding domain; Region: CoA_binding; smart00881 1033813012903 CoA-ligase; Region: Ligase_CoA; pfam00549 1033813012904 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1033813012905 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1033813012906 transmembrane helices; other site 1033813012907 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1033813012908 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1033813012909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813012910 active site 1033813012911 phosphorylation site [posttranslational modification] 1033813012912 intermolecular recognition site; other site 1033813012913 dimerization interface [polypeptide binding]; other site 1033813012914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813012915 Walker A motif; other site 1033813012916 ATP binding site [chemical binding]; other site 1033813012917 Walker B motif; other site 1033813012918 arginine finger; other site 1033813012919 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1033813012920 potential frameshift: common BLAST hit: gi|215489400|ref|YP_002331831.1| sensory histidine kinase in two-component system 1033813012921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813012922 dimer interface [polypeptide binding]; other site 1033813012923 phosphorylation site [posttranslational modification] 1033813012924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813012925 ATP binding site [chemical binding]; other site 1033813012926 Mg2+ binding site [ion binding]; other site 1033813012927 G-X-G motif; other site 1033813012928 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1033813012929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813012930 active site 1033813012931 motif I; other site 1033813012932 motif II; other site 1033813012933 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1033813012934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1033813012935 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1033813012936 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1033813012937 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1033813012938 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1033813012939 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1033813012940 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1033813012941 dimer interface [polypeptide binding]; other site 1033813012942 ssDNA binding site [nucleotide binding]; other site 1033813012943 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1033813012944 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1033813012945 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1033813012946 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1033813012947 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1033813012948 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1033813012949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813012950 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1033813012951 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1033813012952 DNA binding residues [nucleotide binding] 1033813012953 dimer interface [polypeptide binding]; other site 1033813012954 [2Fe-2S] cluster binding site [ion binding]; other site 1033813012955 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1033813012956 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1033813012957 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1033813012958 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033813012959 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813012960 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1033813012961 putative dimerization interface [polypeptide binding]; other site 1033813012962 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1033813012963 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1033813012964 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1033813012965 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1033813012966 Na binding site [ion binding]; other site 1033813012967 Predicted membrane protein [Function unknown]; Region: COG3162 1033813012968 acetyl-CoA synthetase; Provisional; Region: PRK00174 1033813012969 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1033813012970 active site 1033813012971 CoA binding site [chemical binding]; other site 1033813012972 acyl-activating enzyme (AAE) consensus motif; other site 1033813012973 AMP binding site [chemical binding]; other site 1033813012974 acetate binding site [chemical binding]; other site 1033813012975 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 1033813012976 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 1033813012977 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1033813012978 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1033813012979 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1033813012980 heme lyase subunit NrfE; Provisional; Region: PRK10369 1033813012981 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 1033813012982 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1033813012983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1033813012984 binding surface 1033813012985 TPR motif; other site 1033813012986 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1033813012987 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1033813012988 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1033813012989 Sel1-like repeats; Region: SEL1; smart00671 1033813012990 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1033813012991 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813012992 Walker A/P-loop; other site 1033813012993 ATP binding site [chemical binding]; other site 1033813012994 Q-loop/lid; other site 1033813012995 ABC transporter signature motif; other site 1033813012996 Walker B; other site 1033813012997 D-loop; other site 1033813012998 H-loop/switch region; other site 1033813012999 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1033813013000 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813013001 Walker A/P-loop; other site 1033813013002 ATP binding site [chemical binding]; other site 1033813013003 Q-loop/lid; other site 1033813013004 ABC transporter signature motif; other site 1033813013005 Walker B; other site 1033813013006 D-loop; other site 1033813013007 H-loop/switch region; other site 1033813013008 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1033813013009 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1033813013010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813013011 dimer interface [polypeptide binding]; other site 1033813013012 conserved gate region; other site 1033813013013 ABC-ATPase subunit interface; other site 1033813013014 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1033813013015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813013016 dimer interface [polypeptide binding]; other site 1033813013017 conserved gate region; other site 1033813013018 putative PBP binding loops; other site 1033813013019 ABC-ATPase subunit interface; other site 1033813013020 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1033813013021 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1033813013022 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813013023 molybdopterin cofactor binding site; other site 1033813013024 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1033813013025 molybdopterin cofactor binding site; other site 1033813013026 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1033813013027 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 1033813013028 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 1033813013029 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1033813013030 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1033813013031 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1033813013032 HlyD family secretion protein; Region: HlyD_3; pfam13437 1033813013033 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1033813013034 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1033813013035 D-allose kinase; Provisional; Region: PRK09698 1033813013036 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033813013037 nucleotide binding site [chemical binding]; other site 1033813013038 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1033813013039 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1033813013040 substrate binding site [chemical binding]; other site 1033813013041 hexamer interface [polypeptide binding]; other site 1033813013042 metal binding site [ion binding]; metal-binding site 1033813013043 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033813013044 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1033813013045 TM-ABC transporter signature motif; other site 1033813013046 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 1033813013047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813013048 Walker A/P-loop; other site 1033813013049 ATP binding site [chemical binding]; other site 1033813013050 Q-loop/lid; other site 1033813013051 ABC transporter signature motif; other site 1033813013052 Walker B; other site 1033813013053 D-loop; other site 1033813013054 H-loop/switch region; other site 1033813013055 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1033813013056 D-allose transporter subunit; Provisional; Region: PRK09701 1033813013057 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 1033813013058 ligand binding site [chemical binding]; other site 1033813013059 dimerization interface [polypeptide binding]; other site 1033813013060 zinc binding site [ion binding]; other site 1033813013061 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 1033813013062 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1033813013063 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1033813013064 putative active site [active] 1033813013065 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 1033813013066 putative hydrolase; Provisional; Region: PRK02113 1033813013067 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 1033813013068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813013069 Coenzyme A binding pocket [chemical binding]; other site 1033813013070 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 1033813013071 Guanylate kinase; Region: Guanylate_kin; pfam00625 1033813013072 active site 1033813013073 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1033813013074 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1033813013075 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1033813013076 active site 1033813013077 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1033813013078 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1033813013079 Walker A/P-loop; other site 1033813013080 ATP binding site [chemical binding]; other site 1033813013081 Q-loop/lid; other site 1033813013082 ABC transporter signature motif; other site 1033813013083 Walker B; other site 1033813013084 D-loop; other site 1033813013085 H-loop/switch region; other site 1033813013086 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1033813013087 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033813013088 Walker A/P-loop; other site 1033813013089 ATP binding site [chemical binding]; other site 1033813013090 Q-loop/lid; other site 1033813013091 ABC transporter signature motif; other site 1033813013092 Walker B; other site 1033813013093 D-loop; other site 1033813013094 H-loop/switch region; other site 1033813013095 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1033813013096 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1033813013097 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 1033813013098 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 1033813013099 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1033813013100 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 1033813013101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813013102 DNA-binding site [nucleotide binding]; DNA binding site 1033813013103 UTRA domain; Region: UTRA; pfam07702 1033813013104 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1033813013105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033813013106 dimer interface [polypeptide binding]; other site 1033813013107 conserved gate region; other site 1033813013108 putative PBP binding loops; other site 1033813013109 ABC-ATPase subunit interface; other site 1033813013110 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1033813013111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813013112 substrate binding pocket [chemical binding]; other site 1033813013113 membrane-bound complex binding site; other site 1033813013114 hinge residues; other site 1033813013115 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 1033813013116 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1033813013117 Walker A/P-loop; other site 1033813013118 ATP binding site [chemical binding]; other site 1033813013119 Q-loop/lid; other site 1033813013120 ABC transporter signature motif; other site 1033813013121 Walker B; other site 1033813013122 D-loop; other site 1033813013123 H-loop/switch region; other site 1033813013124 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1033813013125 dimer interface [polypeptide binding]; other site 1033813013126 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1033813013127 hypothetical protein; Provisional; Region: PRK10220 1033813013128 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1033813013129 PhnA protein; Region: PhnA; pfam03831 1033813013130 hypothetical protein; Provisional; Region: PRK09866 1033813013131 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1033813013132 G1 box; other site 1033813013133 GTP/Mg2+ binding site [chemical binding]; other site 1033813013134 G2 box; other site 1033813013135 Switch I region; other site 1033813013136 G3 box; other site 1033813013137 Switch II region; other site 1033813013138 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1033813013139 G2 box; other site 1033813013140 Switch I region; other site 1033813013141 G3 box; other site 1033813013142 Switch II region; other site 1033813013143 G4 box; other site 1033813013144 G5 box; other site 1033813013145 YjcZ-like protein; Region: YjcZ; pfam13990 1033813013146 proline/glycine betaine transporter; Provisional; Region: PRK10642 1033813013147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813013148 putative substrate translocation pore; other site 1033813013149 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1033813013150 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1033813013151 HAMP domain; Region: HAMP; pfam00672 1033813013152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813013153 dimer interface [polypeptide binding]; other site 1033813013154 phosphorylation site [posttranslational modification] 1033813013155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813013156 ATP binding site [chemical binding]; other site 1033813013157 Mg2+ binding site [ion binding]; other site 1033813013158 G-X-G motif; other site 1033813013159 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1033813013160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813013161 active site 1033813013162 phosphorylation site [posttranslational modification] 1033813013163 intermolecular recognition site; other site 1033813013164 dimerization interface [polypeptide binding]; other site 1033813013165 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813013166 DNA binding site [nucleotide binding] 1033813013167 putative metal dependent hydrolase; Provisional; Region: PRK11598 1033813013168 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1033813013169 Sulfatase; Region: Sulfatase; pfam00884 1033813013170 arginine:agmatin antiporter; Provisional; Region: PRK10644 1033813013171 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1033813013172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813013173 arginine decarboxylase; Provisional; Region: PRK15029 1033813013174 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1033813013175 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1033813013176 homodimer interface [polypeptide binding]; other site 1033813013177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813013178 catalytic residue [active] 1033813013179 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1033813013180 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 1033813013181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813013182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813013183 alpha-galactosidase; Provisional; Region: PRK15076 1033813013184 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1033813013185 NAD binding site [chemical binding]; other site 1033813013186 sugar binding site [chemical binding]; other site 1033813013187 divalent metal binding site [ion binding]; other site 1033813013188 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1033813013189 dimer interface [polypeptide binding]; other site 1033813013190 hypothetical protein; Provisional; Region: PRK09867 1033813013191 fumarate hydratase; Provisional; Region: PRK15389 1033813013192 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1033813013193 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1033813013194 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1033813013195 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1033813013196 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1033813013197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813013198 active site 1033813013199 phosphorylation site [posttranslational modification] 1033813013200 intermolecular recognition site; other site 1033813013201 dimerization interface [polypeptide binding]; other site 1033813013202 Transcriptional regulator; Region: CitT; pfam12431 1033813013203 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1033813013204 PAS domain; Region: PAS; smart00091 1033813013205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813013206 ATP binding site [chemical binding]; other site 1033813013207 Mg2+ binding site [ion binding]; other site 1033813013208 G-X-G motif; other site 1033813013209 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1033813013210 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 1033813013211 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1033813013212 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1033813013213 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1033813013214 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1033813013215 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1033813013216 PapC N-terminal domain; Region: PapC_N; pfam13954 1033813013217 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1033813013218 PapC C-terminal domain; Region: PapC_C; pfam13953 1033813013219 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 1033813013220 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 1033813013221 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1033813013222 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1033813013223 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1033813013224 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1033813013225 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1033813013226 dimer interface [polypeptide binding]; other site 1033813013227 putative anticodon binding site; other site 1033813013228 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1033813013229 motif 1; other site 1033813013230 active site 1033813013231 motif 2; other site 1033813013232 motif 3; other site 1033813013233 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1033813013234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813013235 putative substrate translocation pore; other site 1033813013236 POT family; Region: PTR2; pfam00854 1033813013237 lysine decarboxylase CadA; Provisional; Region: PRK15400 1033813013238 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1033813013239 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1033813013240 homodimer interface [polypeptide binding]; other site 1033813013241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813013242 catalytic residue [active] 1033813013243 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1033813013244 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1033813013245 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 1033813013246 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1033813013247 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1033813013248 Phosphotransferase enzyme family; Region: APH; pfam01636 1033813013249 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1033813013250 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1033813013251 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1033813013252 intersubunit interface [polypeptide binding]; other site 1033813013253 active site 1033813013254 Zn2+ binding site [ion binding]; other site 1033813013255 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1033813013256 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1033813013257 DNA binding residues [nucleotide binding] 1033813013258 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1033813013259 gluconate transporter; Region: gntP; TIGR00791 1033813013260 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1033813013261 putative dehydratase; Provisional; Region: PRK08211 1033813013262 Dehydratase family; Region: ILVD_EDD; cl00340 1033813013263 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1033813013264 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1033813013265 inhibitor site; inhibition site 1033813013266 active site 1033813013267 dimer interface [polypeptide binding]; other site 1033813013268 catalytic residue [active] 1033813013269 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1033813013270 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1033813013271 Bacterial transcriptional regulator; Region: IclR; pfam01614 1033813013272 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1033813013273 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1033813013274 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813013275 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1033813013276 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1033813013277 substrate binding site [chemical binding]; other site 1033813013278 hexamer interface [polypeptide binding]; other site 1033813013279 metal binding site [ion binding]; metal-binding site 1033813013280 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033813013281 active site 1033813013282 phosphorylation site [posttranslational modification] 1033813013283 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 1033813013284 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1033813013285 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 1033813013286 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1033813013287 active site 1033813013288 P-loop; other site 1033813013289 phosphorylation site [posttranslational modification] 1033813013290 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1033813013291 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1033813013292 oligomer interface [polypeptide binding]; other site 1033813013293 active site 1033813013294 metal binding site [ion binding]; metal-binding site 1033813013295 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 1033813013296 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1033813013297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813013298 S-adenosylmethionine binding site [chemical binding]; other site 1033813013299 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1033813013300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813013301 Coenzyme A binding pocket [chemical binding]; other site 1033813013302 hypothetical protein; Provisional; Region: PRK13687 1033813013303 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1033813013304 hypothetical protein; Provisional; Region: PRK06815 1033813013305 tetramer interface [polypeptide binding]; other site 1033813013306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813013307 catalytic residue [active] 1033813013308 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1033813013309 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1033813013310 propionate/acetate kinase; Provisional; Region: PRK12379 1033813013311 Acetokinase family; Region: Acetate_kinase; cl17229 1033813013312 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1033813013313 Pyruvate formate lyase 1; Region: PFL1; cd01678 1033813013314 coenzyme A binding site [chemical binding]; other site 1033813013315 active site 1033813013316 catalytic residues [active] 1033813013317 glycine loop; other site 1033813013318 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1033813013319 homotrimer interaction site [polypeptide binding]; other site 1033813013320 putative active site [active] 1033813013321 L-serine dehydratase TdcG; Provisional; Region: PRK15040 1033813013322 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1033813013323 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1033813013324 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1033813013325 integrase; Provisional; Region: PRK09692 1033813013326 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1033813013327 active site 1033813013328 Int/Topo IB signature motif; other site 1033813013329 putative transcriptional regulator; Provisional; Region: PRK11640 1033813013330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813013331 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1033813013332 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1033813013333 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1033813013334 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1033813013335 DsbD alpha interface [polypeptide binding]; other site 1033813013336 catalytic residues [active] 1033813013337 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1033813013338 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1033813013339 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1033813013340 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1033813013341 Aspartase; Region: Aspartase; cd01357 1033813013342 active sites [active] 1033813013343 tetramer interface [polypeptide binding]; other site 1033813013344 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1033813013345 putative transporter; Provisional; Region: PRK11021 1033813013346 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1033813013347 oligomerisation interface [polypeptide binding]; other site 1033813013348 mobile loop; other site 1033813013349 roof hairpin; other site 1033813013350 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1033813013351 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1033813013352 ring oligomerisation interface [polypeptide binding]; other site 1033813013353 ATP/Mg binding site [chemical binding]; other site 1033813013354 stacking interactions; other site 1033813013355 hinge regions; other site 1033813013356 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1033813013357 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1033813013358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813013359 FeS/SAM binding site; other site 1033813013360 elongation factor P; Validated; Region: PRK00529 1033813013361 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1033813013362 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1033813013363 RNA binding site [nucleotide binding]; other site 1033813013364 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1033813013365 RNA binding site [nucleotide binding]; other site 1033813013366 entericidin A; Provisional; Region: PRK09810 1033813013367 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1033813013368 multidrug efflux system protein; Provisional; Region: PRK11431 1033813013369 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1033813013370 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1033813013371 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1033813013372 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1033813013373 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1033813013374 Iron-sulfur protein interface; other site 1033813013375 proximal quinone binding site [chemical binding]; other site 1033813013376 C-subunit interface; other site 1033813013377 distal quinone binding site; other site 1033813013378 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1033813013379 D-subunit interface [polypeptide binding]; other site 1033813013380 Iron-sulfur protein interface; other site 1033813013381 proximal quinone binding site [chemical binding]; other site 1033813013382 distal quinone binding site [chemical binding]; other site 1033813013383 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1033813013384 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1033813013385 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1033813013386 L-aspartate oxidase; Provisional; Region: PRK06175 1033813013387 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1033813013388 poxB regulator PoxA; Provisional; Region: PRK09350 1033813013389 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1033813013390 motif 1; other site 1033813013391 dimer interface [polypeptide binding]; other site 1033813013392 active site 1033813013393 motif 2; other site 1033813013394 motif 3; other site 1033813013395 inner membrane transporter YjeM; Provisional; Region: PRK15238 1033813013396 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 1033813013397 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1033813013398 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 1033813013399 DNA-binding site [nucleotide binding]; DNA binding site 1033813013400 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1033813013401 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1033813013402 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1033813013403 GTPase RsgA; Reviewed; Region: PRK12288 1033813013404 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1033813013405 RNA binding site [nucleotide binding]; other site 1033813013406 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1033813013407 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1033813013408 GTP/Mg2+ binding site [chemical binding]; other site 1033813013409 G4 box; other site 1033813013410 G5 box; other site 1033813013411 G1 box; other site 1033813013412 Switch I region; other site 1033813013413 G2 box; other site 1033813013414 G3 box; other site 1033813013415 Switch II region; other site 1033813013416 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1033813013417 catalytic site [active] 1033813013418 putative active site [active] 1033813013419 putative substrate binding site [chemical binding]; other site 1033813013420 dimer interface [polypeptide binding]; other site 1033813013421 epoxyqueuosine reductase; Region: TIGR00276 1033813013422 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1033813013423 putative carbohydrate kinase; Provisional; Region: PRK10565 1033813013424 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 1033813013425 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1033813013426 putative substrate binding site [chemical binding]; other site 1033813013427 putative ATP binding site [chemical binding]; other site 1033813013428 ADP-binding protein; Provisional; Region: PRK10646 1033813013429 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1033813013430 AMIN domain; Region: AMIN; pfam11741 1033813013431 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1033813013432 active site 1033813013433 metal binding site [ion binding]; metal-binding site 1033813013434 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1033813013435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813013436 ATP binding site [chemical binding]; other site 1033813013437 Mg2+ binding site [ion binding]; other site 1033813013438 G-X-G motif; other site 1033813013439 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1033813013440 ATP binding site [chemical binding]; other site 1033813013441 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1033813013442 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1033813013443 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1033813013444 bacterial Hfq-like; Region: Hfq; cd01716 1033813013445 hexamer interface [polypeptide binding]; other site 1033813013446 Sm1 motif; other site 1033813013447 RNA binding site [nucleotide binding]; other site 1033813013448 Sm2 motif; other site 1033813013449 GTPase HflX; Provisional; Region: PRK11058 1033813013450 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1033813013451 HflX GTPase family; Region: HflX; cd01878 1033813013452 G1 box; other site 1033813013453 GTP/Mg2+ binding site [chemical binding]; other site 1033813013454 Switch I region; other site 1033813013455 G2 box; other site 1033813013456 G3 box; other site 1033813013457 Switch II region; other site 1033813013458 G4 box; other site 1033813013459 G5 box; other site 1033813013460 FtsH protease regulator HflK; Provisional; Region: PRK10930 1033813013461 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1033813013462 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1033813013463 FtsH protease regulator HflC; Provisional; Region: PRK11029 1033813013464 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1033813013465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1033813013466 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1033813013467 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1033813013468 GDP-binding site [chemical binding]; other site 1033813013469 ACT binding site; other site 1033813013470 IMP binding site; other site 1033813013471 Predicted transcriptional regulator [Transcription]; Region: COG1959 1033813013472 transcriptional repressor NsrR; Provisional; Region: PRK11014 1033813013473 exoribonuclease R; Provisional; Region: PRK11642 1033813013474 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1033813013475 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1033813013476 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1033813013477 RNB domain; Region: RNB; pfam00773 1033813013478 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1033813013479 RNA binding site [nucleotide binding]; other site 1033813013480 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1033813013481 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1033813013482 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1033813013483 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 1033813013484 PspA/IM30 family; Region: PspA_IM30; pfam04012 1033813013485 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1033813013486 Predicted membrane protein [Function unknown]; Region: COG3766 1033813013487 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1033813013488 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1033813013489 Predicted integral membrane protein [Function unknown]; Region: COG5463 1033813013490 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1033813013491 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1033813013492 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1033813013493 FAD binding site [chemical binding]; other site 1033813013494 substrate binding site [chemical binding]; other site 1033813013495 catalytic residues [active] 1033813013496 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1033813013497 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1033813013498 esterase; Provisional; Region: PRK10566 1033813013499 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1033813013500 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1033813013501 transcriptional repressor UlaR; Provisional; Region: PRK13509 1033813013502 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1033813013503 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813013504 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1033813013505 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1033813013506 potential frameshift: common BLAST hit: gi|218692526|ref|YP_002400738.1| PTS system ascorbate-specific transporter subunit IIC 1033813013507 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1033813013508 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1033813013509 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1033813013510 active site 1033813013511 P-loop; other site 1033813013512 phosphorylation site [posttranslational modification] 1033813013513 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033813013514 active site 1033813013515 phosphorylation site [posttranslational modification] 1033813013516 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1033813013517 active site 1033813013518 dimer interface [polypeptide binding]; other site 1033813013519 magnesium binding site [ion binding]; other site 1033813013520 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1033813013521 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1033813013522 AP (apurinic/apyrimidinic) site pocket; other site 1033813013523 DNA interaction; other site 1033813013524 Metal-binding active site; metal-binding site 1033813013525 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1033813013526 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1033813013527 intersubunit interface [polypeptide binding]; other site 1033813013528 active site 1033813013529 Zn2+ binding site [ion binding]; other site 1033813013530 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1033813013531 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1033813013532 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1033813013533 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1033813013534 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1033813013535 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1033813013536 Helix-turn-helix domain; Region: HTH_31; pfam13560 1033813013537 sequence-specific DNA binding site [nucleotide binding]; other site 1033813013538 salt bridge; other site 1033813013539 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1033813013540 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1033813013541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813013542 D-galactonate transporter; Region: 2A0114; TIGR00893 1033813013543 putative substrate translocation pore; other site 1033813013544 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1033813013545 L-aspartate oxidase; Provisional; Region: PRK06175 1033813013546 L-aspartate oxidase; Provisional; Region: PRK06175 1033813013547 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1033813013548 Coenzyme A transferase; Region: CoA_trans; smart00882 1033813013549 Coenzyme A transferase; Region: CoA_trans; cl17247 1033813013550 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1033813013551 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1033813013552 substrate binding site [chemical binding]; other site 1033813013553 oxyanion hole (OAH) forming residues; other site 1033813013554 trimer interface [polypeptide binding]; other site 1033813013555 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1033813013556 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1033813013557 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 1033813013558 putative NAD(P) binding site [chemical binding]; other site 1033813013559 active site 1033813013560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1033813013561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813013562 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1033813013563 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1033813013564 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1033813013565 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1033813013566 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1033813013567 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1033813013568 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1033813013569 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1033813013570 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1033813013571 Hemerythrin-like domain; Region: Hr-like; cd12108 1033813013572 Fe binding site [ion binding]; other site 1033813013573 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1033813013574 EamA-like transporter family; Region: EamA; pfam00892 1033813013575 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1033813013576 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1033813013577 NADP binding site [chemical binding]; other site 1033813013578 Predicted transcriptional regulators [Transcription]; Region: COG1733 1033813013579 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1033813013580 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1033813013581 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1033813013582 active site 1033813013583 metal binding site [ion binding]; metal-binding site 1033813013584 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1033813013585 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1033813013586 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1033813013587 active site 1033813013588 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1033813013589 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1033813013590 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1033813013591 Domain of unknown function DUF21; Region: DUF21; pfam01595 1033813013592 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1033813013593 Transporter associated domain; Region: CorC_HlyC; smart01091 1033813013594 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1033813013595 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1033813013596 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1033813013597 Surface antigen; Region: Bac_surface_Ag; pfam01103 1033813013598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1033813013599 Family of unknown function (DUF490); Region: DUF490; pfam04357 1033813013600 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1033813013601 dimerization interface [polypeptide binding]; other site 1033813013602 putative active site pocket [active] 1033813013603 putative catalytic residue [active] 1033813013604 antitoxin ChpS; Provisional; Region: PRK11347 1033813013605 toxin ChpB; Provisional; Region: PRK09812 1033813013606 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1033813013607 dimer interface [polypeptide binding]; other site 1033813013608 substrate binding site [chemical binding]; other site 1033813013609 metal binding sites [ion binding]; metal-binding site 1033813013610 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1033813013611 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1033813013612 putative ligand binding site [chemical binding]; other site 1033813013613 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1033813013614 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1033813013615 Walker A/P-loop; other site 1033813013616 ATP binding site [chemical binding]; other site 1033813013617 Q-loop/lid; other site 1033813013618 ABC transporter signature motif; other site 1033813013619 Walker B; other site 1033813013620 D-loop; other site 1033813013621 H-loop/switch region; other site 1033813013622 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1033813013623 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033813013624 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1033813013625 TM-ABC transporter signature motif; other site 1033813013626 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033813013627 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1033813013628 TM-ABC transporter signature motif; other site 1033813013629 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1033813013630 AMP binding site [chemical binding]; other site 1033813013631 metal binding site [ion binding]; metal-binding site 1033813013632 active site 1033813013633 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1033813013634 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1033813013635 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1033813013636 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1033813013637 hypothetical protein; Provisional; Region: PRK05255 1033813013638 peptidase PmbA; Provisional; Region: PRK11040 1033813013639 cytochrome b562; Provisional; Region: PRK15058 1033813013640 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1033813013641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1033813013642 FeS/SAM binding site; other site 1033813013643 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1033813013644 ATP cone domain; Region: ATP-cone; pfam03477 1033813013645 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1033813013646 effector binding site; other site 1033813013647 active site 1033813013648 Zn binding site [ion binding]; other site 1033813013649 glycine loop; other site 1033813013650 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1033813013651 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1033813013652 Ca binding site [ion binding]; other site 1033813013653 active site 1033813013654 catalytic site [active] 1033813013655 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1033813013656 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1033813013657 active site turn [active] 1033813013658 phosphorylation site [posttranslational modification] 1033813013659 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1033813013660 trehalose repressor; Provisional; Region: treR; PRK09492 1033813013661 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033813013662 DNA binding site [nucleotide binding] 1033813013663 domain linker motif; other site 1033813013664 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1033813013665 dimerization interface [polypeptide binding]; other site 1033813013666 ligand binding site [chemical binding]; other site 1033813013667 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1033813013668 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1033813013669 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033813013670 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1033813013671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813013672 motif II; other site 1033813013673 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1033813013674 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1033813013675 homotrimer interaction site [polypeptide binding]; other site 1033813013676 putative active site [active] 1033813013677 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1033813013678 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1033813013679 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1033813013680 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 1033813013681 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1033813013682 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1033813013683 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1033813013684 homotrimer interaction site [polypeptide binding]; other site 1033813013685 putative active site [active] 1033813013686 oxidoreductase; Provisional; Region: PRK12742 1033813013687 classical (c) SDRs; Region: SDR_c; cd05233 1033813013688 NAD(P) binding site [chemical binding]; other site 1033813013689 active site 1033813013690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1033813013691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813013692 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1033813013693 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1033813013694 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1033813013695 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1033813013696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 1033813013697 RNase E inhibitor protein; Provisional; Region: PRK11191 1033813013698 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1033813013699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813013700 Coenzyme A binding pocket [chemical binding]; other site 1033813013701 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1033813013702 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1033813013703 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1033813013704 HIGH motif; other site 1033813013705 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1033813013706 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1033813013707 active site 1033813013708 KMSKS motif; other site 1033813013709 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1033813013710 tRNA binding surface [nucleotide binding]; other site 1033813013711 anticodon binding site; other site 1033813013712 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1033813013713 DNA polymerase III subunit chi; Validated; Region: PRK05728 1033813013714 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1033813013715 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1033813013716 interface (dimer of trimers) [polypeptide binding]; other site 1033813013717 Substrate-binding/catalytic site; other site 1033813013718 Zn-binding sites [ion binding]; other site 1033813013719 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1033813013720 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1033813013721 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1033813013722 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1033813013723 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1033813013724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1033813013725 Walker A motif; other site 1033813013726 ATP binding site [chemical binding]; other site 1033813013727 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1033813013728 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1033813013729 putative NAD(P) binding site [chemical binding]; other site 1033813013730 putative substrate binding site [chemical binding]; other site 1033813013731 catalytic Zn binding site [ion binding]; other site 1033813013732 structural Zn binding site [ion binding]; other site 1033813013733 dimer interface [polypeptide binding]; other site 1033813013734 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033813013735 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1033813013736 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1033813013737 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1033813013738 Bacterial transcriptional regulator; Region: IclR; pfam01614 1033813013739 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1033813013740 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1033813013741 active site 1033813013742 inhibitor site; inhibition site 1033813013743 dimer interface [polypeptide binding]; other site 1033813013744 catalytic residue [active] 1033813013745 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1033813013746 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1033813013747 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1033813013748 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1033813013749 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1033813013750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813013751 D-galactonate transporter; Region: 2A0114; TIGR00893 1033813013752 putative substrate translocation pore; other site 1033813013753 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1033813013754 Transposase; Region: HTH_Tnp_1; pfam01527 1033813013755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1033813013756 Transposase; Region: HTH_Tnp_1; cl17663 1033813013757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1033813013758 HTH-like domain; Region: HTH_21; pfam13276 1033813013759 Integrase core domain; Region: rve; pfam00665 1033813013760 Integrase core domain; Region: rve_2; pfam13333 1033813013761 L-lactate permease; Region: Lactate_perm; cl00701 1033813013762 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1033813013763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1033813013764 Transposase; Region: HTH_Tnp_1; pfam01527 1033813013765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1033813013766 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1033813013767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1033813013768 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1033813013769 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1033813013770 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1033813013771 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 1033813013772 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813013773 N-terminal plug; other site 1033813013774 ligand-binding site [chemical binding]; other site 1033813013775 Integrase core domain; Region: rve_3; cl15866 1033813013776 Integrase core domain; Region: rve; pfam00665 1033813013777 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1033813013778 active site 1033813013779 catalytic residues [active] 1033813013780 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1033813013781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813013782 putative substrate translocation pore; other site 1033813013783 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1033813013784 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1033813013785 substrate binding site [chemical binding]; other site 1033813013786 dimer interface [polypeptide binding]; other site 1033813013787 ATP binding site [chemical binding]; other site 1033813013788 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1033813013789 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1033813013790 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033813013791 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1033813013792 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1033813013793 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1033813013794 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1033813013795 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033813013796 Predicted membrane protein [Function unknown]; Region: COG4325 1033813013797 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1033813013798 BCCT family transporter; Region: BCCT; cl00569 1033813013799 putative transposase OrfB; Reviewed; Region: PHA02517 1033813013800 Integrase core domain; Region: rve; pfam00665 1033813013801 Integrase core domain; Region: rve_3; pfam13683 1033813013802 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1033813013803 Helix-turn-helix domain; Region: HTH_38; pfam13936 1033813013804 Integrase core domain; Region: rve; pfam00665 1033813013805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1033813013806 Transposase; Region: HTH_Tnp_1; pfam01527 1033813013807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1033813013808 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1033813013809 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1033813013810 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 1033813013811 homodimer interface [polypeptide binding]; other site 1033813013812 putative GKAP docking site [polypeptide binding]; other site 1033813013813 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1033813013814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1033813013815 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1033813013816 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1033813013817 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1033813013818 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 1033813013819 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1033813013820 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1033813013821 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1033813013822 HTH-like domain; Region: HTH_21; pfam13276 1033813013823 Integrase core domain; Region: rve; pfam00665 1033813013824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1033813013825 Integrase core domain; Region: rve; pfam00665 1033813013826 Integrase core domain; Region: rve_3; cl15866 1033813013827 transposase/IS protein; Provisional; Region: PRK09183 1033813013828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813013829 Walker A motif; other site 1033813013830 ATP binding site [chemical binding]; other site 1033813013831 Walker B motif; other site 1033813013832 arginine finger; other site 1033813013833 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1033813013834 MULE transposase domain; Region: MULE; pfam10551 1033813013835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1033813013836 putative iron-regulated outer membrane virulence protein; Provisional; Region: PRK13484 1033813013837 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813013838 N-terminal plug; other site 1033813013839 ligand-binding site [chemical binding]; other site 1033813013840 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1033813013841 Predicted GTPase [General function prediction only]; Region: COG3596 1033813013842 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1033813013843 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 1033813013844 hypothetical protein; Provisional; Region: PRK09945 1033813013845 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1033813013846 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1033813013847 AAA domain; Region: AAA_12; pfam13087 1033813013848 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 1033813013849 putative active site [active] 1033813013850 catalytic site [active] 1033813013851 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1033813013852 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1033813013853 Kelch motif; Region: Kelch_1; pfam01344 1033813013854 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1033813013855 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033813013856 active site 1033813013857 Int/Topo IB signature motif; other site 1033813013858 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 1033813013859 Int/Topo IB signature motif; other site 1033813013860 Fimbrial protein; Region: Fimbrial; cl01416 1033813013861 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1033813013862 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1033813013863 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1033813013864 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1033813013865 outer membrane usher protein; Provisional; Region: PRK15193 1033813013866 PapC N-terminal domain; Region: PapC_N; pfam13954 1033813013867 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1033813013868 PapC C-terminal domain; Region: PapC_C; pfam13953 1033813013869 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1033813013870 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1033813013871 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 1033813013872 mannosyl binding site [chemical binding]; other site 1033813013873 Fimbrial protein; Region: Fimbrial; pfam00419 1033813013874 fructuronate transporter; Provisional; Region: PRK10034 1033813013875 gluconate transporter; Region: gntP; TIGR00791 1033813013876 mannonate dehydratase; Region: uxuA; TIGR00695 1033813013877 mannonate dehydratase; Provisional; Region: PRK03906 1033813013878 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1033813013879 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1033813013880 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1033813013881 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1033813013882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813013883 DNA-binding site [nucleotide binding]; DNA binding site 1033813013884 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1033813013885 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 1033813013886 cell density-dependent motility repressor; Provisional; Region: PRK10082 1033813013887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033813013888 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1033813013889 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 1033813013890 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 1033813013891 dimer interface [polypeptide binding]; other site 1033813013892 active site 1033813013893 hypothetical protein; Provisional; Region: PRK10519 1033813013894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1033813013895 Nucleoside recognition; Region: Gate; pfam07670 1033813013896 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1033813013897 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1033813013898 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1033813013899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 1033813013900 SdiA-regulated; Region: SdiA-regulated; cd09971 1033813013901 putative active site [active] 1033813013902 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1033813013903 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 1033813013904 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 1033813013905 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 1033813013906 Predicted membrane protein [Function unknown]; Region: COG2733 1033813013907 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 1033813013908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813013909 putative substrate translocation pore; other site 1033813013910 putative transposase; Provisional; Region: PRK09857 1033813013911 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1033813013912 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1033813013913 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813013914 DNA-binding site [nucleotide binding]; DNA binding site 1033813013915 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1033813013916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813013917 homodimer interface [polypeptide binding]; other site 1033813013918 catalytic residue [active] 1033813013919 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1033813013920 endoribonuclease SymE; Provisional; Region: PRK13605 1033813013921 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1033813013922 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1033813013923 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1033813013924 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1033813013925 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1033813013926 Restriction endonuclease; Region: Mrr_cat; pfam04471 1033813013927 Protein of unknown function (DUF497); Region: DUF497; cl01108 1033813013928 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 1033813013929 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1033813013930 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1033813013931 P-loop, Walker A motif; other site 1033813013932 Base recognition motif; other site 1033813013933 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1033813013934 Uncharacterized small protein [Function unknown]; Region: COG2879 1033813013935 carbon starvation protein A; Provisional; Region: PRK15015 1033813013936 Carbon starvation protein CstA; Region: CstA; pfam02554 1033813013937 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1033813013938 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1033813013939 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1033813013940 dimer interface [polypeptide binding]; other site 1033813013941 ligand binding site [chemical binding]; other site 1033813013942 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033813013943 dimerization interface [polypeptide binding]; other site 1033813013944 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1033813013945 dimer interface [polypeptide binding]; other site 1033813013946 putative CheW interface [polypeptide binding]; other site 1033813013947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813013948 D-galactonate transporter; Region: 2A0114; TIGR00893 1033813013949 putative substrate translocation pore; other site 1033813013950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033813013951 DNA-binding site [nucleotide binding]; DNA binding site 1033813013952 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1033813013953 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1033813013954 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1033813013955 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1033813013956 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1033813013957 putative NAD(P) binding site [chemical binding]; other site 1033813013958 catalytic Zn binding site [ion binding]; other site 1033813013959 structural Zn binding site [ion binding]; other site 1033813013960 phosphoglycerol transferase I; Provisional; Region: PRK03776 1033813013961 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1033813013962 hypothetical protein; Provisional; Region: PRK11667 1033813013963 DNA replication protein DnaC; Validated; Region: PRK07952 1033813013964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813013965 Walker A motif; other site 1033813013966 ATP binding site [chemical binding]; other site 1033813013967 Walker B motif; other site 1033813013968 primosomal protein DnaI; Provisional; Region: PRK02854 1033813013969 hypothetical protein; Provisional; Region: PRK09917 1033813013970 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1033813013971 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1033813013972 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1033813013973 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813013974 DNA binding residues [nucleotide binding] 1033813013975 dimerization interface [polypeptide binding]; other site 1033813013976 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1033813013977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033813013978 DNA binding residues [nucleotide binding] 1033813013979 dimerization interface [polypeptide binding]; other site 1033813013980 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1033813013981 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1033813013982 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1033813013983 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1033813013984 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1033813013985 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1033813013986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813013987 S-adenosylmethionine binding site [chemical binding]; other site 1033813013988 DNA polymerase III subunit psi; Validated; Region: PRK06856 1033813013989 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1033813013990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033813013991 Coenzyme A binding pocket [chemical binding]; other site 1033813013992 dUMP phosphatase; Provisional; Region: PRK09449 1033813013993 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813013994 motif II; other site 1033813013995 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1033813013996 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1033813013997 G1 box; other site 1033813013998 putative GEF interaction site [polypeptide binding]; other site 1033813013999 GTP/Mg2+ binding site [chemical binding]; other site 1033813014000 Switch I region; other site 1033813014001 G2 box; other site 1033813014002 G3 box; other site 1033813014003 Switch II region; other site 1033813014004 G4 box; other site 1033813014005 G5 box; other site 1033813014006 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1033813014007 periplasmic protein; Provisional; Region: PRK10568 1033813014008 BON domain; Region: BON; pfam04972 1033813014009 BON domain; Region: BON; pfam04972 1033813014010 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1033813014011 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1033813014012 active site 1033813014013 nucleophile elbow; other site 1033813014014 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1033813014015 active site 1033813014016 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1033813014017 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1033813014018 hypothetical protein; Provisional; Region: PRK10977 1033813014019 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1033813014020 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1033813014021 intersubunit interface [polypeptide binding]; other site 1033813014022 active site 1033813014023 catalytic residue [active] 1033813014024 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1033813014025 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1033813014026 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1033813014027 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1033813014028 phosphopentomutase; Provisional; Region: PRK05362 1033813014029 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1033813014030 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1033813014031 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1033813014032 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 1033813014033 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1033813014034 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1033813014035 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1033813014036 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1033813014037 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1033813014038 hypothetical protein; Provisional; Region: PRK11246 1033813014039 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1033813014040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033813014041 motif II; other site 1033813014042 DNA repair protein RadA; Region: sms; TIGR00416 1033813014043 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1033813014044 Walker A motif/ATP binding site; other site 1033813014045 ATP binding site [chemical binding]; other site 1033813014046 Walker B motif; other site 1033813014047 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1033813014048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813014049 non-specific DNA binding site [nucleotide binding]; other site 1033813014050 salt bridge; other site 1033813014051 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1033813014052 sequence-specific DNA binding site [nucleotide binding]; other site 1033813014053 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1033813014054 active site 1033813014055 (T/H)XGH motif; other site 1033813014056 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1033813014057 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1033813014058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033813014059 Walker A/P-loop; other site 1033813014060 ATP binding site [chemical binding]; other site 1033813014061 Q-loop/lid; other site 1033813014062 ABC transporter signature motif; other site 1033813014063 Walker B; other site 1033813014064 D-loop; other site 1033813014065 H-loop/switch region; other site 1033813014066 ABC transporter; Region: ABC_tran_2; pfam12848 1033813014067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033813014068 lytic murein transglycosylase; Provisional; Region: PRK11619 1033813014069 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1033813014070 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1033813014071 catalytic residue [active] 1033813014072 Trp operon repressor; Provisional; Region: PRK01381 1033813014073 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 1033813014074 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033813014075 catalytic core [active] 1033813014076 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1033813014077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033813014078 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1033813014079 hypothetical protein; Provisional; Region: PRK10756 1033813014080 CreA protein; Region: CreA; pfam05981 1033813014081 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1033813014082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813014083 active site 1033813014084 phosphorylation site [posttranslational modification] 1033813014085 intermolecular recognition site; other site 1033813014086 dimerization interface [polypeptide binding]; other site 1033813014087 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813014088 DNA binding site [nucleotide binding] 1033813014089 sensory histidine kinase CreC; Provisional; Region: PRK11100 1033813014090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033813014091 dimerization interface [polypeptide binding]; other site 1033813014092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033813014093 dimer interface [polypeptide binding]; other site 1033813014094 phosphorylation site [posttranslational modification] 1033813014095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033813014096 ATP binding site [chemical binding]; other site 1033813014097 Mg2+ binding site [ion binding]; other site 1033813014098 G-X-G motif; other site 1033813014099 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 1033813014100 two-component response regulator; Provisional; Region: PRK11173 1033813014101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033813014102 active site 1033813014103 phosphorylation site [posttranslational modification] 1033813014104 intermolecular recognition site; other site 1033813014105 dimerization interface [polypeptide binding]; other site 1033813014106 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033813014107 DNA binding site [nucleotide binding] 1033813014108 putative RNA methyltransferase; Provisional; Region: PRK10433 1033813014109 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 1033813014110 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1033813014111 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1033813014112 putative catalytic residues [active] 1033813014113 putative nucleotide binding site [chemical binding]; other site 1033813014114 putative aspartate binding site [chemical binding]; other site 1033813014115 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1033813014116 dimer interface [polypeptide binding]; other site 1033813014117 putative threonine allosteric regulatory site; other site 1033813014118 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1033813014119 putative threonine allosteric regulatory site; other site 1033813014120 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1033813014121 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1033813014122 homoserine kinase; Region: thrB; TIGR00191 1033813014123 Protein of unknown function; Region: YhfT; pfam10797 1033813014124 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1033813014125 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1033813014126 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1033813014127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033813014128 catalytic residue [active] 1033813014129 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1033813014130 hypothetical protein; Validated; Region: PRK02101 1033813014131 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1033813014132 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1033813014133 transaldolase-like protein; Provisional; Region: PTZ00411 1033813014134 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1033813014135 active site 1033813014136 dimer interface [polypeptide binding]; other site 1033813014137 catalytic residue [active] 1033813014138 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1033813014139 MPT binding site; other site 1033813014140 trimer interface [polypeptide binding]; other site 1033813014141 hypothetical protein; Provisional; Region: PRK10659 1033813014142 hypothetical protein; Provisional; Region: PRK10236 1033813014143 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 1033813014144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1033813014145 hypothetical protein; Provisional; Region: PRK10154 1033813014146 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1033813014147 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1033813014148 nucleotide binding site [chemical binding]; other site 1033813014149 NEF interaction site [polypeptide binding]; other site 1033813014150 SBD interface [polypeptide binding]; other site 1033813014151 chaperone protein DnaJ; Provisional; Region: PRK10767 1033813014152 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1033813014153 HSP70 interaction site [polypeptide binding]; other site 1033813014154 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1033813014155 substrate binding site [polypeptide binding]; other site 1033813014156 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1033813014157 Zn binding sites [ion binding]; other site 1033813014158 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1033813014159 dimer interface [polypeptide binding]; other site 1033813014160 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1033813014161 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1033813014162 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1033813014163 PapC N-terminal domain; Region: PapC_N; pfam13954 1033813014164 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1033813014165 PapC C-terminal domain; Region: PapC_C; pfam13953 1033813014166 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 1033813014167 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1033813014168 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1033813014169 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1033813014170 Fimbrial protein; Region: Fimbrial; pfam00419 1033813014171 Fimbrial protein; Region: Fimbrial; pfam00419 1033813014172 PapG carbohydrate / receptor binding domain (CBD); PapG, the adhesin of the P-pili, is situated at the tip, mediating the attachment of uropathogenic Escherichia coli to the uroepithelium of the human kidney; PapG has a two-domain architecture: a...; Region: PapG_CBD; cd00239 1033813014173 putative membrane interaction site; other site 1033813014174 receptor/carbohydrate binding site; other site 1033813014175 PapG chaperone-binding domain; Region: PapG_C; pfam03628 1033813014176 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1033813014177 Predicted transcriptional regulator [Transcription]; Region: COG2378 1033813014178 WYL domain; Region: WYL; pfam13280 1033813014179 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1033813014180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1033813014181 TPR motif; other site 1033813014182 binding surface 1033813014183 integrase; Provisional; Region: PRK09692 1033813014184 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1033813014185 active site 1033813014186 Int/Topo IB signature motif; other site 1033813014187 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1033813014188 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033813014189 substrate binding pocket [chemical binding]; other site 1033813014190 membrane-bound complex binding site; other site 1033813014191 hinge residues; other site 1033813014192 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1033813014193 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1033813014194 dimerization interface [polypeptide binding]; other site 1033813014195 DPS ferroxidase diiron center [ion binding]; other site 1033813014196 ion pore; other site 1033813014197 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1033813014198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1033813014199 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1033813014200 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1033813014201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1033813014202 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1033813014203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1033813014204 Transposase; Region: HTH_Tnp_1; pfam01527 1033813014205 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1033813014206 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 1033813014207 MobA/MobL family; Region: MobA_MobL; pfam03389 1033813014208 Initiator Replication protein; Region: Rep_3; pfam01051 1033813014209 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1033813014210 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1033813014211 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1033813014212 N-terminal plug; other site 1033813014213 ligand-binding site [chemical binding]; other site 1033813014214 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1033813014215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1033813014216 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1033813014217 IucA / IucC family; Region: IucA_IucC; pfam04183 1033813014218 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1033813014219 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1033813014220 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1033813014221 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1033813014222 IucA / IucC family; Region: IucA_IucC; pfam04183 1033813014223 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1033813014224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033813014225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1033813014226 putative substrate translocation pore; other site 1033813014227 Protein of unknown function, DUF417; Region: DUF417; pfam04224 1033813014228 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1033813014229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1033813014230 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1033813014231 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1033813014232 putative DNA binding site [nucleotide binding]; other site 1033813014233 putative Zn2+ binding site [ion binding]; other site 1033813014234 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 1033813014235 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1033813014236 Rop protein; Region: Rop; pfam01815 1033813014237 Phage-related protein, tail component [Function unknown]; Region: COG4733 1033813014238 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033813014239 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033813014240 active site 1033813014241 DNA binding site [nucleotide binding] 1033813014242 Int/Topo IB signature motif; other site 1033813014243 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1033813014244 exonuclease VIII; Reviewed; Region: PRK09709 1033813014245 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1033813014246 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1033813014247 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 1033813014248 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1033813014249 Walker A motif; other site 1033813014250 ATP binding site [chemical binding]; other site 1033813014251 Walker B motif; other site 1033813014252 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 1033813014253 putative DNA polymerase type B; Provisional; Region: PHA02735 1033813014254 ORF6N domain; Region: ORF6N; pfam10543 1033813014255 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1033813014256 conjugal transfer protein TraD; Provisional; Region: PRK13700 1033813014257 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 1033813014258 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1033813014259 AAA domain; Region: AAA_30; pfam13604 1033813014260 DNA helicase TraI; Region: TraI; pfam07057 1033813014261 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1033813014262 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1033813014263 dimer interface [polypeptide binding]; other site 1033813014264 ssDNA binding site [nucleotide binding]; other site 1033813014265 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1033813014266 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 1033813014267 ParB-like nuclease domain; Region: ParBc; pfam02195 1033813014268 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1033813014269 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 1033813014270 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 1033813014271 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1033813014272 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1033813014273 FaeA-like protein; Region: FaeA; pfam04703 1033813014274 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1033813014275 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1033813014276 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1033813014277 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 1033813014278 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1033813014279 Integrase core domain; Region: rve; pfam00665 1033813014280 putative transposase OrfB; Reviewed; Region: PHA02517 1033813014281 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 1033813014282 Helix-turn-helix domain; Region: HTH_36; pfam13730 1033813014283 primosomal protein DnaI; Provisional; Region: PRK02854 1033813014284 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1033813014285 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 1033813014286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813014287 non-specific DNA binding site [nucleotide binding]; other site 1033813014288 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1033813014289 salt bridge; other site 1033813014290 sequence-specific DNA binding site [nucleotide binding]; other site 1033813014291 Domain of unknown function (DUF3527); Region: DUF3527; pfam12043 1033813014292 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1033813014293 Catalytic site [active] 1033813014294 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 1033813014295 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1033813014296 Replication protein P; Region: Phage_lambda_P; pfam06992 1033813014297 Pyocin large subunit [General function prediction only]; Region: COG5529 1033813014298 Helix-turn-helix domain; Region: HTH_36; pfam13730 1033813014299 primosomal protein DnaI; Provisional; Region: PRK02854 1033813014300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033813014301 sequence-specific DNA binding site [nucleotide binding]; other site 1033813014302 salt bridge; other site 1033813014303 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1033813014304 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 1033813014305 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1033813014306 MT-A70; Region: MT-A70; cl01947 1033813014307 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1033813014308 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1033813014309 active site 1033813014310 metal binding site [ion binding]; metal-binding site 1033813014311 integrase; Provisional; Region: PRK09692 1033813014312 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1033813014313 active site 1033813014314 Int/Topo IB signature motif; other site 1033813014315 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1033813014316 Predicted chitinase [General function prediction only]; Region: COG3179 1033813014317 catalytic residue [active] 1033813014318 Right handed beta helix region; Region: Beta_helix; pfam13229 1033813014319 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1033813014320 cytochrome b; Validated; Region: CYTB; MTH00046 1033813014321 structural protein; Region: PHA01972 1033813014322 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 1033813014323 putative lysin; Region: PHA00658 1033813014324 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1033813014325 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1033813014326 catalytic residue [active] 1033813014327 hypothetical protein; Region: PHA01733 1033813014328 hypothetical protein; Region: PHA00661 1033813014329 hypothetical protein; Region: PHA00662 1033813014330 hypothetical protein; Region: PHA00669 1033813014331 hypothetical protein; Region: PHA00664 1033813014332 major capsid protein; Region: PHA00665 1033813014333 putative protease; Region: PHA00666 1033813014334 hypothetical protein; Region: PHA00670 1033813014335 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 1033813014336 hypothetical protein; Region: PHA01971 1033813014337 Terminase small subunit; Region: Terminase_2; pfam03592 1033813014338 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1033813014339 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1033813014340 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1033813014341 Transposase; Region: HTH_Tnp_1; cl17663 1033813014342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1033813014343 HTH-like domain; Region: HTH_21; pfam13276 1033813014344 Integrase core domain; Region: rve; pfam00665 1033813014345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1033813014346 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 1033813014347 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 1033813014348 putative replication protein; Provisional; Region: PRK12377 1033813014349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033813014350 Walker A motif; other site 1033813014351 ATP binding site [chemical binding]; other site 1033813014352 Walker B motif; other site 1033813014353 arginine finger; other site 1033813014354 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1033813014355 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 1033813014356 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1033813014357 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1033813014358 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1033813014359 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1033813014360 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1033813014361 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1033813014362 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1033813014363 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1033813014364 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1033813014365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033813014366 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1033813014367 DNA methylase; Region: N6_N4_Mtase; pfam01555 1033813014368 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1033813014369 Antitermination protein; Region: Antiterm; pfam03589 1033813014370 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1033813014371 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1033813014372 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1033813014373 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1033813014374 Transposase; Region: HTH_Tnp_1; cl17663