-- dump date 20140619_085202 -- class Genbank::misc_feature -- table misc_feature_note -- id note 585395000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 585395000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 585395000003 putative catalytic residues [active] 585395000004 putative nucleotide binding site [chemical binding]; other site 585395000005 putative aspartate binding site [chemical binding]; other site 585395000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 585395000007 dimer interface [polypeptide binding]; other site 585395000008 putative threonine allosteric regulatory site; other site 585395000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 585395000010 putative threonine allosteric regulatory site; other site 585395000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 585395000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 585395000013 homoserine kinase; Region: thrB; TIGR00191 585395000014 Protein of unknown function; Region: YhfT; pfam10797 585395000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585395000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 585395000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 585395000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395000019 catalytic residue [active] 585395000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 585395000021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585395000022 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585395000023 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585395000024 hypothetical protein; Validated; Region: PRK02101 585395000025 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 585395000026 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 585395000027 transaldolase-like protein; Provisional; Region: PTZ00411 585395000028 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 585395000029 active site 585395000030 dimer interface [polypeptide binding]; other site 585395000031 catalytic residue [active] 585395000032 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 585395000033 MPT binding site; other site 585395000034 trimer interface [polypeptide binding]; other site 585395000035 hypothetical protein; Provisional; Region: PRK10659 585395000036 hypothetical protein; Provisional; Region: PRK10236 585395000037 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 585395000038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 585395000039 hypothetical protein; Provisional; Region: PRK10154 585395000040 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 585395000041 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 585395000042 nucleotide binding site [chemical binding]; other site 585395000043 NEF interaction site [polypeptide binding]; other site 585395000044 SBD interface [polypeptide binding]; other site 585395000045 chaperone protein DnaJ; Provisional; Region: PRK10767 585395000046 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585395000047 HSP70 interaction site [polypeptide binding]; other site 585395000048 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 585395000049 substrate binding site [polypeptide binding]; other site 585395000050 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585395000051 Zn binding sites [ion binding]; other site 585395000052 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 585395000053 dimer interface [polypeptide binding]; other site 585395000054 Hok/gef family; Region: HOK_GEF; pfam01848 585395000055 Hok/gef family; Region: HOK_GEF; pfam01848 585395000056 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 585395000057 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 585395000058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395000059 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 585395000060 putative dimerization interface [polypeptide binding]; other site 585395000061 conserved predicted protein, C-terminal part 585395000062 conserved predicted protein, partial 585395000063 outer membrane usher protein precursor, C-terminal part 585395000064 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 585395000065 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 585395000066 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 585395000067 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 585395000068 active site 585395000069 Riboflavin kinase; Region: Flavokinase; smart00904 585395000070 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 585395000071 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 585395000072 HIGH motif; other site 585395000073 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 585395000074 active site 585395000075 KMSKS motif; other site 585395000076 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 585395000077 tRNA binding surface [nucleotide binding]; other site 585395000078 anticodon binding site; other site 585395000079 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585395000080 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 585395000081 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 585395000082 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585395000083 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 585395000084 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 585395000085 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585395000086 active site 585395000087 tetramer interface [polypeptide binding]; other site 585395000088 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 585395000089 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 585395000090 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 585395000091 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 585395000092 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 585395000093 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 585395000094 catalytic site [active] 585395000095 subunit interface [polypeptide binding]; other site 585395000096 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 585395000097 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585395000098 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 585395000099 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 585395000100 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585395000101 ATP-grasp domain; Region: ATP-grasp_4; cl17255 585395000102 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 585395000103 IMP binding site; other site 585395000104 dimer interface [polypeptide binding]; other site 585395000105 interdomain contacts; other site 585395000106 partial ornithine binding site; other site 585395000107 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 585395000108 carnitine operon protein CaiE; Provisional; Region: PRK13627 585395000109 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 585395000110 putative trimer interface [polypeptide binding]; other site 585395000111 putative metal binding site [ion binding]; other site 585395000112 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 585395000113 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585395000114 substrate binding site [chemical binding]; other site 585395000115 oxyanion hole (OAH) forming residues; other site 585395000116 trimer interface [polypeptide binding]; other site 585395000117 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 585395000118 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 585395000119 acyl-activating enzyme (AAE) consensus motif; other site 585395000120 putative AMP binding site [chemical binding]; other site 585395000121 putative active site [active] 585395000122 putative CoA binding site [chemical binding]; other site 585395000123 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 585395000124 CoA-transferase family III; Region: CoA_transf_3; pfam02515 585395000125 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 585395000126 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 585395000127 active site 585395000128 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 585395000129 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 585395000130 Ligand binding site [chemical binding]; other site 585395000131 Electron transfer flavoprotein domain; Region: ETF; pfam01012 585395000132 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 585395000133 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 585395000134 Ligand binding site [chemical binding]; other site 585395000135 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 585395000136 putative oxidoreductase FixC; Provisional; Region: PRK10157 585395000137 ferredoxin-like protein FixX; Provisional; Region: PRK15449 585395000138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395000139 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 585395000140 putative substrate translocation pore; other site 585395000141 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 585395000142 potassium:proton antiporter KefC, N-terminal part 585395000143 potassium:proton antiporter KefC , C-terminal part 585395000144 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 585395000145 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 585395000146 folate binding site [chemical binding]; other site 585395000147 NADP+ binding site [chemical binding]; other site 585395000148 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 585395000149 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 585395000150 active site 585395000151 metal binding site [ion binding]; metal-binding site 585395000152 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 585395000153 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 585395000154 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 585395000155 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 585395000156 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 585395000157 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 585395000158 SurA N-terminal domain; Region: SurA_N; pfam09312 585395000159 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 585395000160 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 585395000161 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 585395000162 OstA-like protein; Region: OstA; pfam03968 585395000163 Organic solvent tolerance protein; Region: OstA_C; pfam04453 585395000164 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 585395000165 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 585395000166 putative metal binding site [ion binding]; other site 585395000167 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585395000168 HSP70 interaction site [polypeptide binding]; other site 585395000169 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 585395000170 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585395000171 active site 585395000172 ATP-dependent helicase HepA; Validated; Region: PRK04914 585395000173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395000174 ATP binding site [chemical binding]; other site 585395000175 putative Mg++ binding site [ion binding]; other site 585395000176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395000177 nucleotide binding region [chemical binding]; other site 585395000178 ATP-binding site [chemical binding]; other site 585395000179 DNA polymerase II; Reviewed; Region: PRK05762 585395000180 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 585395000181 active site 585395000182 catalytic site [active] 585395000183 substrate binding site [chemical binding]; other site 585395000184 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 585395000185 active site 585395000186 metal-binding site 585395000187 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585395000188 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585395000189 intersubunit interface [polypeptide binding]; other site 585395000190 active site 585395000191 Zn2+ binding site [ion binding]; other site 585395000192 L-arabinose isomerase; Provisional; Region: PRK02929 585395000193 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 585395000194 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 585395000195 trimer interface [polypeptide binding]; other site 585395000196 putative substrate binding site [chemical binding]; other site 585395000197 putative metal binding site [ion binding]; other site 585395000198 ribulokinase; Provisional; Region: PRK04123 585395000199 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 585395000200 N- and C-terminal domain interface [polypeptide binding]; other site 585395000201 active site 585395000202 MgATP binding site [chemical binding]; other site 585395000203 catalytic site [active] 585395000204 metal binding site [ion binding]; metal-binding site 585395000205 carbohydrate binding site [chemical binding]; other site 585395000206 homodimer interface [polypeptide binding]; other site 585395000207 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 585395000208 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585395000209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395000210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395000211 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585395000212 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585395000213 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 585395000214 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 585395000215 Walker A/P-loop; other site 585395000216 ATP binding site [chemical binding]; other site 585395000217 Q-loop/lid; other site 585395000218 ABC transporter signature motif; other site 585395000219 Walker B; other site 585395000220 D-loop; other site 585395000221 H-loop/switch region; other site 585395000222 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 585395000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395000224 dimer interface [polypeptide binding]; other site 585395000225 conserved gate region; other site 585395000226 putative PBP binding loops; other site 585395000227 ABC-ATPase subunit interface; other site 585395000228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395000229 dimer interface [polypeptide binding]; other site 585395000230 conserved gate region; other site 585395000231 putative PBP binding loops; other site 585395000232 ABC-ATPase subunit interface; other site 585395000233 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 585395000234 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 585395000235 transcriptional regulator SgrR; Provisional; Region: PRK13626 585395000236 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 585395000237 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 585395000238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395000239 sugar efflux transporter; Region: 2A0120; TIGR00899 585395000240 putative substrate translocation pore; other site 585395000241 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 585395000242 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 585395000243 substrate binding site [chemical binding]; other site 585395000244 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 585395000245 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 585395000246 substrate binding site [chemical binding]; other site 585395000247 ligand binding site [chemical binding]; other site 585395000248 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 585395000249 tartrate dehydrogenase; Region: TTC; TIGR02089 585395000250 2-isopropylmalate synthase; Validated; Region: PRK00915 585395000251 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 585395000252 active site 585395000253 catalytic residues [active] 585395000254 metal binding site [ion binding]; metal-binding site 585395000255 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 585395000256 leu operon leader peptide; Provisional; Region: PRK09925 585395000257 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 585395000258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395000259 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 585395000260 putative substrate binding pocket [chemical binding]; other site 585395000261 putative dimerization interface [polypeptide binding]; other site 585395000262 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 585395000263 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585395000264 PYR/PP interface [polypeptide binding]; other site 585395000265 dimer interface [polypeptide binding]; other site 585395000266 TPP binding site [chemical binding]; other site 585395000267 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585395000268 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585395000269 TPP-binding site [chemical binding]; other site 585395000270 dimer interface [polypeptide binding]; other site 585395000271 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 585395000272 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 585395000273 putative valine binding site [chemical binding]; other site 585395000274 dimer interface [polypeptide binding]; other site 585395000275 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 585395000276 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 585395000277 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585395000278 DNA binding site [nucleotide binding] 585395000279 domain linker motif; other site 585395000280 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 585395000281 dimerization interface [polypeptide binding]; other site 585395000282 ligand binding site [chemical binding]; other site 585395000283 mraZ protein; Region: TIGR00242 585395000284 MraZ protein; Region: MraZ; pfam02381 585395000285 MraZ protein; Region: MraZ; pfam02381 585395000286 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 585395000287 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 585395000288 cell division protein FtsL; Provisional; Region: PRK10772 585395000289 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 585395000290 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 585395000291 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 585395000292 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 585395000293 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585395000294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585395000295 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585395000296 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 585395000297 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585395000298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585395000299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585395000300 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 585395000301 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 585395000302 Mg++ binding site [ion binding]; other site 585395000303 putative catalytic motif [active] 585395000304 putative substrate binding site [chemical binding]; other site 585395000305 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 585395000306 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585395000307 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585395000308 cell division protein FtsW; Provisional; Region: PRK10774 585395000309 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 585395000310 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 585395000311 active site 585395000312 homodimer interface [polypeptide binding]; other site 585395000313 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 585395000314 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585395000315 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585395000316 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585395000317 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 585395000318 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 585395000319 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 585395000320 cell division protein FtsQ; Provisional; Region: PRK10775 585395000321 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 585395000322 Cell division protein FtsQ; Region: FtsQ; pfam03799 585395000323 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 585395000324 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585395000325 Cell division protein FtsA; Region: FtsA; pfam14450 585395000326 cell division protein FtsZ; Validated; Region: PRK09330 585395000327 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 585395000328 nucleotide binding site [chemical binding]; other site 585395000329 SulA interaction site; other site 585395000330 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 585395000331 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 585395000332 SecA regulator SecM; Provisional; Region: PRK02943 585395000333 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 585395000334 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 585395000335 SEC-C motif; Region: SEC-C; pfam02810 585395000336 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 585395000337 active site 585395000338 8-oxo-dGMP binding site [chemical binding]; other site 585395000339 nudix motif; other site 585395000340 metal binding site [ion binding]; metal-binding site 585395000341 DNA gyrase inhibitor; Reviewed; Region: PRK00418 585395000342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 585395000343 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 585395000344 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 585395000345 CoA-binding site [chemical binding]; other site 585395000346 ATP-binding [chemical binding]; other site 585395000347 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 585395000348 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 585395000349 active site 585395000350 type IV pilin biogenesis protein; Provisional; Region: PRK10573 585395000351 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585395000352 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585395000353 hypothetical protein; Provisional; Region: PRK10436 585395000354 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 585395000355 Walker A motif; other site 585395000356 ATP binding site [chemical binding]; other site 585395000357 Walker B motif; other site 585395000358 putative major pilin subunit; Provisional; Region: PRK10574 585395000359 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585395000360 Pilin (bacterial filament); Region: Pilin; pfam00114 585395000361 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 585395000362 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 585395000363 dimerization interface [polypeptide binding]; other site 585395000364 active site 585395000365 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 585395000366 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 585395000367 amidase catalytic site [active] 585395000368 Zn binding residues [ion binding]; other site 585395000369 substrate binding site [chemical binding]; other site 585395000370 regulatory protein AmpE; Provisional; Region: PRK10987 585395000371 aromatic amino acid transporter; Provisional; Region: PRK10238 585395000372 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585395000373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395000374 DNA-binding site [nucleotide binding]; DNA binding site 585395000375 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585395000376 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 585395000377 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 585395000378 dimer interface [polypeptide binding]; other site 585395000379 TPP-binding site [chemical binding]; other site 585395000380 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 585395000381 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585395000382 E3 interaction surface; other site 585395000383 lipoyl attachment site [posttranslational modification]; other site 585395000384 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585395000385 E3 interaction surface; other site 585395000386 lipoyl attachment site [posttranslational modification]; other site 585395000387 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585395000388 E3 interaction surface; other site 585395000389 lipoyl attachment site [posttranslational modification]; other site 585395000390 e3 binding domain; Region: E3_binding; pfam02817 585395000391 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 585395000392 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 585395000393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585395000394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395000395 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585395000396 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 585395000397 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 585395000398 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 585395000399 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 585395000400 substrate binding site [chemical binding]; other site 585395000401 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 585395000402 substrate binding site [chemical binding]; other site 585395000403 ligand binding site [chemical binding]; other site 585395000404 hypothetical protein; Provisional; Region: PRK05248 585395000405 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 585395000406 spermidine synthase; Provisional; Region: PRK00811 585395000407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395000408 S-adenosylmethionine binding site [chemical binding]; other site 585395000409 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 585395000410 multicopper oxidase; Provisional; Region: PRK10965 585395000411 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 585395000412 Multicopper oxidase; Region: Cu-oxidase; pfam00394 585395000413 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 585395000414 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 585395000415 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 585395000416 Trp docking motif [polypeptide binding]; other site 585395000417 putative active site [active] 585395000418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585395000419 active site 585395000420 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 585395000421 active site clefts [active] 585395000422 zinc binding site [ion binding]; other site 585395000423 dimer interface [polypeptide binding]; other site 585395000424 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 585395000425 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585395000426 Walker A/P-loop; other site 585395000427 ATP binding site [chemical binding]; other site 585395000428 Q-loop/lid; other site 585395000429 ABC transporter signature motif; other site 585395000430 Walker B; other site 585395000431 D-loop; other site 585395000432 H-loop/switch region; other site 585395000433 inner membrane transport permease; Provisional; Region: PRK15066 585395000434 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585395000435 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585395000436 active pocket/dimerization site; other site 585395000437 active site 585395000438 phosphorylation site [posttranslational modification] 585395000439 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 585395000440 putative active site [active] 585395000441 putative metal binding site [ion binding]; other site 585395000442 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 585395000443 tetramerization interface [polypeptide binding]; other site 585395000444 active site 585395000445 Uncharacterized conserved protein [Function unknown]; Region: COG5464 585395000446 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585395000447 pantoate--beta-alanine ligase; Region: panC; TIGR00018 585395000448 Pantoate-beta-alanine ligase; Region: PanC; cd00560 585395000449 active site 585395000450 ATP-binding site [chemical binding]; other site 585395000451 pantoate-binding site; other site 585395000452 HXXH motif; other site 585395000453 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 585395000454 oligomerization interface [polypeptide binding]; other site 585395000455 active site 585395000456 metal binding site [ion binding]; metal-binding site 585395000457 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 585395000458 putative fimbrial protein StaF; Provisional; Region: PRK15262 585395000459 putative fimbrial protein StaE; Provisional; Region: PRK15263 585395000460 Fimbrial protein; Region: Fimbrial; cl01416 585395000461 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 585395000462 PapC N-terminal domain; Region: PapC_N; pfam13954 585395000463 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585395000464 PapC C-terminal domain; Region: PapC_C; pfam13953 585395000465 putative chaperone protein EcpD; Provisional; Region: PRK09926 585395000466 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585395000467 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585395000468 Fimbrial protein; Region: Fimbrial; cl01416 585395000469 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 585395000470 catalytic center binding site [active] 585395000471 ATP binding site [chemical binding]; other site 585395000472 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 585395000473 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 585395000474 active site 585395000475 NTP binding site [chemical binding]; other site 585395000476 metal binding triad [ion binding]; metal-binding site 585395000477 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 585395000478 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 585395000479 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 585395000480 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 585395000481 active site 585395000482 nucleotide binding site [chemical binding]; other site 585395000483 HIGH motif; other site 585395000484 KMSKS motif; other site 585395000485 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 585395000486 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 585395000487 2'-5' RNA ligase; Provisional; Region: PRK15124 585395000488 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 585395000489 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 585395000490 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 585395000491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395000492 ATP binding site [chemical binding]; other site 585395000493 putative Mg++ binding site [ion binding]; other site 585395000494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395000495 nucleotide binding region [chemical binding]; other site 585395000496 ATP-binding site [chemical binding]; other site 585395000497 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 585395000498 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 585395000499 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 585395000500 Transglycosylase; Region: Transgly; pfam00912 585395000501 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585395000502 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 585395000503 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585395000504 N-terminal plug; other site 585395000505 ligand-binding site [chemical binding]; other site 585395000506 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 585395000507 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585395000508 Walker A/P-loop; other site 585395000509 ATP binding site [chemical binding]; other site 585395000510 Q-loop/lid; other site 585395000511 ABC transporter signature motif; other site 585395000512 Walker B; other site 585395000513 D-loop; other site 585395000514 H-loop/switch region; other site 585395000515 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 585395000516 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 585395000517 siderophore binding site; other site 585395000518 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585395000519 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585395000520 ABC-ATPase subunit interface; other site 585395000521 dimer interface [polypeptide binding]; other site 585395000522 putative PBP binding regions; other site 585395000523 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585395000524 ABC-ATPase subunit interface; other site 585395000525 dimer interface [polypeptide binding]; other site 585395000526 putative PBP binding regions; other site 585395000527 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 585395000528 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585395000529 inhibitor-cofactor binding pocket; inhibition site 585395000530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395000531 catalytic residue [active] 585395000532 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585395000533 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 585395000534 Cl- selectivity filter; other site 585395000535 Cl- binding residues [ion binding]; other site 585395000536 pore gating glutamate residue; other site 585395000537 dimer interface [polypeptide binding]; other site 585395000538 H+/Cl- coupling transport residue; other site 585395000539 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 585395000540 hypothetical protein; Provisional; Region: PRK10578 585395000541 UPF0126 domain; Region: UPF0126; pfam03458 585395000542 UPF0126 domain; Region: UPF0126; pfam03458 585395000543 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 585395000544 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 585395000545 cobalamin binding residues [chemical binding]; other site 585395000546 putative BtuC binding residues; other site 585395000547 dimer interface [polypeptide binding]; other site 585395000548 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 585395000549 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 585395000550 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 585395000551 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585395000552 Zn2+ binding site [ion binding]; other site 585395000553 Mg2+ binding site [ion binding]; other site 585395000554 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 585395000555 serine endoprotease; Provisional; Region: PRK10942 585395000556 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585395000557 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585395000558 protein binding site [polypeptide binding]; other site 585395000559 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585395000560 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 585395000561 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 585395000562 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 585395000563 hypothetical protein; Provisional; Region: PRK13677 585395000564 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 585395000565 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 585395000566 trimer interface [polypeptide binding]; other site 585395000567 active site 585395000568 substrate binding site [chemical binding]; other site 585395000569 CoA binding site [chemical binding]; other site 585395000570 PII uridylyl-transferase; Provisional; Region: PRK05007 585395000571 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585395000572 metal binding triad; other site 585395000573 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585395000574 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585395000575 Zn2+ binding site [ion binding]; other site 585395000576 Mg2+ binding site [ion binding]; other site 585395000577 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 585395000578 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 585395000579 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 585395000580 active site 585395000581 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 585395000582 rRNA interaction site [nucleotide binding]; other site 585395000583 S8 interaction site; other site 585395000584 putative laminin-1 binding site; other site 585395000585 elongation factor Ts; Provisional; Region: tsf; PRK09377 585395000586 UBA/TS-N domain; Region: UBA; pfam00627 585395000587 Elongation factor TS; Region: EF_TS; pfam00889 585395000588 Elongation factor TS; Region: EF_TS; pfam00889 585395000589 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 585395000590 putative nucleotide binding site [chemical binding]; other site 585395000591 uridine monophosphate binding site [chemical binding]; other site 585395000592 homohexameric interface [polypeptide binding]; other site 585395000593 ribosome recycling factor; Reviewed; Region: frr; PRK00083 585395000594 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 585395000595 hinge region; other site 585395000596 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 585395000597 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 585395000598 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 585395000599 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 585395000600 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 585395000601 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 585395000602 catalytic residue [active] 585395000603 putative FPP diphosphate binding site; other site 585395000604 putative FPP binding hydrophobic cleft; other site 585395000605 dimer interface [polypeptide binding]; other site 585395000606 putative IPP diphosphate binding site; other site 585395000607 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 585395000608 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 585395000609 zinc metallopeptidase RseP; Provisional; Region: PRK10779 585395000610 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 585395000611 active site 585395000612 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 585395000613 protein binding site [polypeptide binding]; other site 585395000614 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 585395000615 putative substrate binding region [chemical binding]; other site 585395000616 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 585395000617 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585395000618 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585395000619 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585395000620 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585395000621 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585395000622 Surface antigen; Region: Bac_surface_Ag; pfam01103 585395000623 periplasmic chaperone; Provisional; Region: PRK10780 585395000624 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 585395000625 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 585395000626 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 585395000627 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 585395000628 trimer interface [polypeptide binding]; other site 585395000629 active site 585395000630 UDP-GlcNAc binding site [chemical binding]; other site 585395000631 lipid binding site [chemical binding]; lipid-binding site 585395000632 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 585395000633 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 585395000634 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 585395000635 active site 585395000636 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 585395000637 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 585395000638 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 585395000639 RNA/DNA hybrid binding site [nucleotide binding]; other site 585395000640 active site 585395000641 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 585395000642 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 585395000643 putative active site [active] 585395000644 putative PHP Thumb interface [polypeptide binding]; other site 585395000645 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 585395000646 generic binding surface II; other site 585395000647 generic binding surface I; other site 585395000648 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 585395000649 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 585395000650 lysine decarboxylase LdcC; Provisional; Region: PRK15399 585395000651 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585395000652 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585395000653 homodimer interface [polypeptide binding]; other site 585395000654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395000655 catalytic residue [active] 585395000656 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585395000657 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 585395000658 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585395000659 putative metal binding site [ion binding]; other site 585395000660 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 585395000661 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 585395000662 Ligand Binding Site [chemical binding]; other site 585395000663 TilS substrate binding domain; Region: TilS; pfam09179 585395000664 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 585395000665 Rho-binding antiterminator; Provisional; Region: PRK11625 585395000666 hypothetical protein; Provisional; Region: PRK04964 585395000667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 585395000668 hypothetical protein; Provisional; Region: PRK09256 585395000669 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 585395000670 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 585395000671 NlpE N-terminal domain; Region: NlpE; pfam04170 585395000672 predicted lipoprotein, C-terminal part 585395000673 predicted lipoprotein, N-terminal part 585395000674 prolyl-tRNA synthetase; Provisional; Region: PRK09194 585395000675 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 585395000676 dimer interface [polypeptide binding]; other site 585395000677 motif 1; other site 585395000678 active site 585395000679 motif 2; other site 585395000680 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 585395000681 putative deacylase active site [active] 585395000682 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 585395000683 active site 585395000684 motif 3; other site 585395000685 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 585395000686 anticodon binding site; other site 585395000687 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 585395000688 homodimer interaction site [polypeptide binding]; other site 585395000689 cofactor binding site; other site 585395000690 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 585395000691 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 585395000692 lipoprotein, YaeC family; Region: TIGR00363 585395000693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395000694 dimer interface [polypeptide binding]; other site 585395000695 conserved gate region; other site 585395000696 ABC-ATPase subunit interface; other site 585395000697 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 585395000698 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 585395000699 Walker A/P-loop; other site 585395000700 ATP binding site [chemical binding]; other site 585395000701 Q-loop/lid; other site 585395000702 ABC transporter signature motif; other site 585395000703 Walker B; other site 585395000704 D-loop; other site 585395000705 H-loop/switch region; other site 585395000706 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 585395000707 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 585395000708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395000709 active site 585395000710 motif I; other site 585395000711 motif II; other site 585395000712 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585395000713 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585395000714 active site 585395000715 catalytic tetrad [active] 585395000716 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585395000717 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395000718 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 585395000719 putative effector binding pocket; other site 585395000720 dimerization interface [polypeptide binding]; other site 585395000721 hypothetical protein; Provisional; Region: PRK05421 585395000722 putative catalytic site [active] 585395000723 putative metal binding site [ion binding]; other site 585395000724 putative phosphate binding site [ion binding]; other site 585395000725 putative catalytic site [active] 585395000726 putative phosphate binding site [ion binding]; other site 585395000727 putative metal binding site [ion binding]; other site 585395000728 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585395000729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395000730 S-adenosylmethionine binding site [chemical binding]; other site 585395000731 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 585395000732 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585395000733 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585395000734 catalytic residue [active] 585395000735 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585395000736 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585395000737 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 585395000738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395000739 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 585395000740 RNA/DNA hybrid binding site [nucleotide binding]; other site 585395000741 active site 585395000742 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 585395000743 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 585395000744 active site 585395000745 catalytic site [active] 585395000746 substrate binding site [chemical binding]; other site 585395000747 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585395000748 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 585395000749 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585395000750 ImpA domain protein; Region: DUF3702; pfam12486 585395000751 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 585395000752 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 585395000753 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 585395000754 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585395000755 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 585395000756 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 585395000757 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 585395000758 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 585395000759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395000760 Walker A motif; other site 585395000761 ATP binding site [chemical binding]; other site 585395000762 Walker B motif; other site 585395000763 arginine finger; other site 585395000764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395000765 Walker A motif; other site 585395000766 ATP binding site [chemical binding]; other site 585395000767 Walker B motif; other site 585395000768 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585395000769 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 585395000770 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 585395000771 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 585395000772 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 585395000773 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 585395000774 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 585395000775 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 585395000776 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 585395000777 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 585395000778 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 585395000779 Protein of unknown function (DUF877); Region: DUF877; pfam05943 585395000780 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 585395000781 Protein of unknown function (DUF770); Region: DUF770; pfam05591 585395000782 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585395000783 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 585395000784 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585395000785 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585395000786 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585395000787 PAAR motif; Region: PAAR_motif; cl15808 585395000788 RHS Repeat; Region: RHS_repeat; pfam05593 585395000789 RHS Repeat; Region: RHS_repeat; pfam05593 585395000790 RHS Repeat; Region: RHS_repeat; pfam05593 585395000791 RHS Repeat; Region: RHS_repeat; pfam05593 585395000792 RHS Repeat; Region: RHS_repeat; cl11982 585395000793 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585395000794 RHS Repeat; Region: RHS_repeat; pfam05593 585395000795 RHS Repeat; Region: RHS_repeat; cl11982 585395000796 RHS Repeat; Region: RHS_repeat; pfam05593 585395000797 RHS protein; Region: RHS; pfam03527 585395000798 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585395000799 RhsI, IS677, H repeat-associated protein, N-terminal fragment 585395000800 RhsG, IS677, H repeat-associated protein, N-terminal part truncated 585395000801 C-N hydrolase family amidase; Provisional; Region: PRK10438 585395000802 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 585395000803 putative active site [active] 585395000804 catalytic triad [active] 585395000805 dimer interface [polypeptide binding]; other site 585395000806 multimer interface [polypeptide binding]; other site 585395000807 C-lysozyme inhibitor; Provisional; Region: PRK09993 585395000808 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 585395000809 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 585395000810 active site 585395000811 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 585395000812 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 585395000813 dimer interface [polypeptide binding]; other site 585395000814 active site 585395000815 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 585395000816 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 585395000817 putative active site [active] 585395000818 putative dimer interface [polypeptide binding]; other site 585395000819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 585395000820 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585395000821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 585395000822 RelB antitoxin; Region: RelB; cl01171 585395000823 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585395000824 NlpC/P60 family; Region: NLPC_P60; pfam00877 585395000825 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 585395000826 HicB family; Region: HicB; pfam05534 585395000827 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 585395000828 FHIPEP family; Region: FHIPEP; pfam00771 585395000829 hypothetical protein; Validated; Region: PRK06778 585395000830 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585395000831 ligand binding site [chemical binding]; other site 585395000832 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 585395000833 active site 585395000834 DNA polymerase IV; Validated; Region: PRK02406 585395000835 DNA binding site [nucleotide binding] 585395000836 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585395000837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395000838 Coenzyme A binding pocket [chemical binding]; other site 585395000839 hypothetical protein; Reviewed; Region: PRK09588 585395000840 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 585395000841 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 585395000842 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 585395000843 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 585395000844 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 585395000845 metal binding site [ion binding]; metal-binding site 585395000846 dimer interface [polypeptide binding]; other site 585395000847 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585395000848 active site 585395000849 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 585395000850 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 585395000851 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585395000852 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585395000853 trimer interface [polypeptide binding]; other site 585395000854 eyelet of channel; other site 585395000855 gamma-glutamyl kinase; Provisional; Region: PRK05429 585395000856 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 585395000857 nucleotide binding site [chemical binding]; other site 585395000858 homotetrameric interface [polypeptide binding]; other site 585395000859 putative phosphate binding site [ion binding]; other site 585395000860 putative allosteric binding site; other site 585395000861 PUA domain; Region: PUA; pfam01472 585395000862 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 585395000863 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 585395000864 putative catalytic cysteine [active] 585395000865 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585395000866 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585395000867 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 585395000868 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 585395000869 XdhC Rossmann domain; Region: XdhC_C; pfam13478 585395000870 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 585395000871 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 585395000872 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 585395000873 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 585395000874 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 585395000875 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 585395000876 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585395000877 catalytic loop [active] 585395000878 iron binding site [ion binding]; other site 585395000879 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 585395000880 conserved predicted inner membrane protein, C-terminal part 585395000881 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 585395000882 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585395000883 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 585395000884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585395000885 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395000886 DNA binding residues [nucleotide binding] 585395000887 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 585395000888 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 585395000889 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585395000890 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585395000891 Filamin/ABP280 repeat; Region: Filamin; pfam00630 585395000892 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585395000893 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585395000894 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585395000895 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 585395000896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395000897 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 585395000898 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585395000899 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585395000900 active site 585395000901 catalytic tetrad [active] 585395000902 Predicted membrane protein [Function unknown]; Region: COG3059 585395000903 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585395000904 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 585395000905 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 585395000906 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395000907 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585395000908 Cupin; Region: Cupin_6; pfam12852 585395000909 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585395000910 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395000911 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 585395000912 Cysteine-rich domain; Region: CCG; pfam02754 585395000913 Cysteine-rich domain; Region: CCG; pfam02754 585395000914 iron-sulfur cluster-binding protein; Region: TIGR00273 585395000915 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 585395000916 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585395000917 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 585395000918 Uncharacterized conserved protein [Function unknown]; Region: COG1556 585395000919 predicted inner membrane protein, C-terminal part 585395000920 predicted inner membrane protein, N-terminal part 585395000921 choline dehydrogenase; Validated; Region: PRK02106 585395000922 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 585395000923 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 585395000924 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 585395000925 tetrameric interface [polypeptide binding]; other site 585395000926 NAD binding site [chemical binding]; other site 585395000927 catalytic residues [active] 585395000928 transcriptional regulator BetI; Validated; Region: PRK00767 585395000929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585395000930 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 585395000931 choline transport protein BetT; Provisional; Region: PRK09928 585395000932 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585395000933 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585395000934 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585395000935 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585395000936 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395000937 DNA binding residues [nucleotide binding] 585395000938 dimerization interface [polypeptide binding]; other site 585395000939 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395000940 predicted DNA-binding transcriptional regulator, LYSR-type, N-terminal part 585395000941 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 585395000942 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 585395000943 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 585395000944 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 585395000945 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 585395000946 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 585395000947 CoA binding domain; Region: CoA_binding; pfam02629 585395000948 CoA-ligase; Region: Ligase_CoA; pfam00549 585395000949 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 585395000950 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 585395000951 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585395000952 putative substrate binding site [chemical binding]; other site 585395000953 nucleotide binding site [chemical binding]; other site 585395000954 nucleotide binding site [chemical binding]; other site 585395000955 homodimer interface [polypeptide binding]; other site 585395000956 putative deaminase; Validated; Region: PRK06846 585395000957 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 585395000958 active site 585395000959 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 585395000960 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 585395000961 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 585395000962 ligand binding site [chemical binding]; other site 585395000963 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585395000964 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585395000965 Walker A/P-loop; other site 585395000966 ATP binding site [chemical binding]; other site 585395000967 Q-loop/lid; other site 585395000968 ABC transporter signature motif; other site 585395000969 Walker B; other site 585395000970 D-loop; other site 585395000971 H-loop/switch region; other site 585395000972 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585395000973 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585395000974 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585395000975 TM-ABC transporter signature motif; other site 585395000976 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585395000977 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585395000978 TM-ABC transporter signature motif; other site 585395000979 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 585395000980 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 585395000981 putative NAD(P) binding site [chemical binding]; other site 585395000982 putative substrate binding site [chemical binding]; other site 585395000983 catalytic Zn binding site [ion binding]; other site 585395000984 structural Zn binding site [ion binding]; other site 585395000985 dimer interface [polypeptide binding]; other site 585395000986 neutral amino-acid efflux system, C-terminal part 585395000987 putative transposase OrfB; Reviewed; Region: PHA02517 585395000988 HTH-like domain; Region: HTH_21; pfam13276 585395000989 Integrase core domain; Region: rve; pfam00665 585395000990 Integrase core domain; Region: rve_3; pfam13683 585395000991 hypothetical protein; Provisional; Region: PRK09929 585395000992 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 585395000993 Propionate catabolism activator; Region: PrpR_N; pfam06506 585395000994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395000995 Walker A motif; other site 585395000996 ATP binding site [chemical binding]; other site 585395000997 Walker B motif; other site 585395000998 arginine finger; other site 585395000999 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585395001000 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 585395001001 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 585395001002 tetramer interface [polypeptide binding]; other site 585395001003 active site 585395001004 Mg2+/Mn2+ binding site [ion binding]; other site 585395001005 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 585395001006 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 585395001007 dimer interface [polypeptide binding]; other site 585395001008 active site 585395001009 citrylCoA binding site [chemical binding]; other site 585395001010 oxalacetate/citrate binding site [chemical binding]; other site 585395001011 coenzyme A binding site [chemical binding]; other site 585395001012 catalytic triad [active] 585395001013 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 585395001014 2-methylcitrate dehydratase; Region: prpD; TIGR02330 585395001015 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 585395001016 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 585395001017 acyl-activating enzyme (AAE) consensus motif; other site 585395001018 putative AMP binding site [chemical binding]; other site 585395001019 putative active site [active] 585395001020 putative CoA binding site [chemical binding]; other site 585395001021 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 585395001022 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 585395001023 Na binding site [ion binding]; other site 585395001024 putative substrate binding site [chemical binding]; other site 585395001025 cytosine deaminase; Provisional; Region: PRK09230 585395001026 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 585395001027 active site 585395001028 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 585395001029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395001030 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 585395001031 dimerization interface [polypeptide binding]; other site 585395001032 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 585395001033 active site clefts [active] 585395001034 zinc binding site [ion binding]; other site 585395001035 dimer interface [polypeptide binding]; other site 585395001036 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 585395001037 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 585395001038 oligomer interface [polypeptide binding]; other site 585395001039 active site 585395001040 putative cyanate transporter; Provisional; Region: cynX; PRK09705 585395001041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395001042 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 585395001043 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 585395001044 active site 585395001045 substrate binding site [chemical binding]; other site 585395001046 trimer interface [polypeptide binding]; other site 585395001047 CoA binding site [chemical binding]; other site 585395001048 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 585395001049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395001050 putative substrate translocation pore; other site 585395001051 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 585395001052 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 585395001053 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 585395001054 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 585395001055 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 585395001056 lac repressor; Reviewed; Region: lacI; PRK09526 585395001057 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585395001058 DNA binding site [nucleotide binding] 585395001059 domain linker motif; other site 585395001060 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 585395001061 ligand binding site [chemical binding]; other site 585395001062 dimerization interface (open form) [polypeptide binding]; other site 585395001063 dimerization interface (closed form) [polypeptide binding]; other site 585395001064 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 585395001065 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585395001066 Bacterial transcriptional regulator; Region: IclR; pfam01614 585395001067 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 585395001068 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 585395001069 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 585395001070 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 585395001071 putative active site [active] 585395001072 Fe(II) binding site [ion binding]; other site 585395001073 putative dimer interface [polypeptide binding]; other site 585395001074 putative tetramer interface [polypeptide binding]; other site 585395001075 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 585395001076 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 585395001077 nucleophilic elbow; other site 585395001078 catalytic triad; other site 585395001079 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 585395001080 acetaldehyde dehydrogenase; Validated; Region: PRK08300 585395001081 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585395001082 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 585395001083 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 585395001084 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 585395001085 active site 585395001086 catalytic residues [active] 585395001087 metal binding site [ion binding]; metal-binding site 585395001088 DmpG-like communication domain; Region: DmpG_comm; pfam07836 585395001089 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 585395001090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395001091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395001092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 585395001093 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 585395001094 S-formylglutathione hydrolase; Region: PLN02442 585395001095 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 585395001096 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 585395001097 substrate binding site [chemical binding]; other site 585395001098 catalytic Zn binding site [ion binding]; other site 585395001099 NAD binding site [chemical binding]; other site 585395001100 structural Zn binding site [ion binding]; other site 585395001101 dimer interface [polypeptide binding]; other site 585395001102 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 585395001103 putative metal binding site [ion binding]; other site 585395001104 putative homodimer interface [polypeptide binding]; other site 585395001105 putative homotetramer interface [polypeptide binding]; other site 585395001106 putative homodimer-homodimer interface [polypeptide binding]; other site 585395001107 putative allosteric switch controlling residues; other site 585395001108 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 585395001109 putative trimer interface [polypeptide binding]; other site 585395001110 putative CoA binding site [chemical binding]; other site 585395001111 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 585395001112 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 585395001113 DXD motif; other site 585395001114 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 585395001115 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 585395001116 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395001117 substrate binding pocket [chemical binding]; other site 585395001118 membrane-bound complex binding site; other site 585395001119 hinge residues; other site 585395001120 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 585395001121 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 585395001122 Walker A/P-loop; other site 585395001123 ATP binding site [chemical binding]; other site 585395001124 Q-loop/lid; other site 585395001125 ABC transporter signature motif; other site 585395001126 Walker B; other site 585395001127 D-loop; other site 585395001128 H-loop/switch region; other site 585395001129 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 585395001130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395001131 dimer interface [polypeptide binding]; other site 585395001132 conserved gate region; other site 585395001133 putative PBP binding loops; other site 585395001134 ABC-ATPase subunit interface; other site 585395001135 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 585395001136 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 585395001137 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 585395001138 dimer interface [polypeptide binding]; other site 585395001139 active site 585395001140 Schiff base residues; other site 585395001141 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 585395001142 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585395001143 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585395001144 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 585395001145 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 585395001146 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585395001147 microcin B17 transporter; Reviewed; Region: PRK11098 585395001148 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 585395001149 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 585395001150 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 585395001151 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 585395001152 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 585395001153 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 585395001154 anti-RssB factor; Provisional; Region: PRK10244 585395001155 alkaline phosphatase; Provisional; Region: PRK10518 585395001156 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 585395001157 dimer interface [polypeptide binding]; other site 585395001158 active site 585395001159 hypothetical protein; Provisional; Region: PRK11505 585395001160 psiF repeat; Region: PsiF_repeat; pfam07769 585395001161 psiF repeat; Region: PsiF_repeat; pfam07769 585395001162 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 585395001163 MASE2 domain; Region: MASE2; pfam05230 585395001164 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395001165 metal binding site [ion binding]; metal-binding site 585395001166 active site 585395001167 I-site; other site 585395001168 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 585395001169 pyrroline-5-carboxylate reductase; Region: PLN02688 585395001170 hypothetical protein; Validated; Region: PRK00124 585395001171 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 585395001172 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 585395001173 ADP binding site [chemical binding]; other site 585395001174 magnesium binding site [ion binding]; other site 585395001175 putative shikimate binding site; other site 585395001176 hypothetical protein; Provisional; Region: PRK10380 585395001177 hypothetical protein; Provisional; Region: PRK10481 585395001178 hypothetical protein; Provisional; Region: PRK10579 585395001179 conserved predicted protein, C-terminal part 585395001180 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 585395001181 fructokinase; Reviewed; Region: PRK09557 585395001182 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585395001183 nucleotide binding site [chemical binding]; other site 585395001184 MFS transport protein AraJ; Provisional; Region: PRK10091 585395001185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395001186 putative substrate translocation pore; other site 585395001187 exonuclease subunit SbcC; Provisional; Region: PRK10246 585395001188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395001189 Walker A/P-loop; other site 585395001190 ATP binding site [chemical binding]; other site 585395001191 Q-loop/lid; other site 585395001192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395001193 ABC transporter signature motif; other site 585395001194 Walker B; other site 585395001195 D-loop; other site 585395001196 H-loop/switch region; other site 585395001197 exonuclease subunit SbcD; Provisional; Region: PRK10966 585395001198 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 585395001199 active site 585395001200 metal binding site [ion binding]; metal-binding site 585395001201 DNA binding site [nucleotide binding] 585395001202 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 585395001203 transcriptional regulator PhoB; Provisional; Region: PRK10161 585395001204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395001205 active site 585395001206 phosphorylation site [posttranslational modification] 585395001207 intermolecular recognition site; other site 585395001208 dimerization interface [polypeptide binding]; other site 585395001209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395001210 DNA binding site [nucleotide binding] 585395001211 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 585395001212 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 585395001213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585395001214 putative active site [active] 585395001215 heme pocket [chemical binding]; other site 585395001216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395001217 dimer interface [polypeptide binding]; other site 585395001218 phosphorylation site [posttranslational modification] 585395001219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395001220 ATP binding site [chemical binding]; other site 585395001221 Mg2+ binding site [ion binding]; other site 585395001222 G-X-G motif; other site 585395001223 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 585395001224 putative proline-specific permease; Provisional; Region: proY; PRK10580 585395001225 Spore germination protein; Region: Spore_permease; cl17796 585395001226 maltodextrin glucosidase; Provisional; Region: PRK10785 585395001227 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 585395001228 homodimer interface [polypeptide binding]; other site 585395001229 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 585395001230 active site 585395001231 homodimer interface [polypeptide binding]; other site 585395001232 catalytic site [active] 585395001233 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 585395001234 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 585395001235 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 585395001236 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 585395001237 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 585395001238 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 585395001239 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 585395001240 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 585395001241 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 585395001242 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 585395001243 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 585395001244 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 585395001245 Protein export membrane protein; Region: SecD_SecF; pfam02355 585395001246 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585395001247 active site 585395001248 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 585395001249 hypothetical protein; Provisional; Region: PRK11530 585395001250 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 585395001251 ATP cone domain; Region: ATP-cone; pfam03477 585395001252 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 585395001253 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 585395001254 catalytic motif [active] 585395001255 Zn binding site [ion binding]; other site 585395001256 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 585395001257 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 585395001258 homopentamer interface [polypeptide binding]; other site 585395001259 active site 585395001260 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 585395001261 putative RNA binding site [nucleotide binding]; other site 585395001262 thiamine monophosphate kinase; Provisional; Region: PRK05731 585395001263 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 585395001264 ATP binding site [chemical binding]; other site 585395001265 dimerization interface [polypeptide binding]; other site 585395001266 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 585395001267 tetramer interfaces [polypeptide binding]; other site 585395001268 binuclear metal-binding site [ion binding]; other site 585395001269 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585395001270 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585395001271 active site 585395001272 catalytic tetrad [active] 585395001273 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 585395001274 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 585395001275 TPP-binding site; other site 585395001276 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585395001277 PYR/PP interface [polypeptide binding]; other site 585395001278 dimer interface [polypeptide binding]; other site 585395001279 TPP binding site [chemical binding]; other site 585395001280 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585395001281 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 585395001282 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 585395001283 substrate binding pocket [chemical binding]; other site 585395001284 chain length determination region; other site 585395001285 substrate-Mg2+ binding site; other site 585395001286 catalytic residues [active] 585395001287 aspartate-rich region 1; other site 585395001288 active site lid residues [active] 585395001289 aspartate-rich region 2; other site 585395001290 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 585395001291 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 585395001292 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 585395001293 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 585395001294 Ligand Binding Site [chemical binding]; other site 585395001295 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585395001296 active site residue [active] 585395001297 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 585395001298 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 585395001299 conserved cys residue [active] 585395001300 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 585395001301 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 585395001302 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 585395001303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 585395001304 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 585395001305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395001306 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585395001307 putative substrate translocation pore; other site 585395001308 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585395001309 Sel1 repeat; Region: Sel1; pfam08238 585395001310 Sel1-like repeats; Region: SEL1; smart00671 585395001311 Sel1-like repeats; Region: SEL1; smart00671 585395001312 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 585395001313 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 585395001314 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 585395001315 UbiA prenyltransferase family; Region: UbiA; pfam01040 585395001316 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 585395001317 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 585395001318 Subunit I/III interface [polypeptide binding]; other site 585395001319 Subunit III/IV interface [polypeptide binding]; other site 585395001320 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 585395001321 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 585395001322 D-pathway; other site 585395001323 Putative ubiquinol binding site [chemical binding]; other site 585395001324 Low-spin heme (heme b) binding site [chemical binding]; other site 585395001325 Putative water exit pathway; other site 585395001326 Binuclear center (heme o3/CuB) [ion binding]; other site 585395001327 K-pathway; other site 585395001328 Putative proton exit pathway; other site 585395001329 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 585395001330 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 585395001331 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 585395001332 muropeptide transporter; Reviewed; Region: ampG; PRK11902 585395001333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395001334 putative substrate translocation pore; other site 585395001335 hypothetical protein; Provisional; Region: PRK11627 585395001336 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 585395001337 transcriptional regulator BolA; Provisional; Region: PRK11628 585395001338 trigger factor; Provisional; Region: tig; PRK01490 585395001339 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585395001340 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 585395001341 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 585395001342 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 585395001343 oligomer interface [polypeptide binding]; other site 585395001344 active site residues [active] 585395001345 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 585395001346 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 585395001347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395001348 Walker A motif; other site 585395001349 ATP binding site [chemical binding]; other site 585395001350 Walker B motif; other site 585395001351 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585395001352 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 585395001353 Found in ATP-dependent protease La (LON); Region: LON; smart00464 585395001354 Found in ATP-dependent protease La (LON); Region: LON; smart00464 585395001355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395001356 Walker A motif; other site 585395001357 ATP binding site [chemical binding]; other site 585395001358 Walker B motif; other site 585395001359 arginine finger; other site 585395001360 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 585395001361 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585395001362 IHF dimer interface [polypeptide binding]; other site 585395001363 IHF - DNA interface [nucleotide binding]; other site 585395001364 periplasmic folding chaperone; Provisional; Region: PRK10788 585395001365 SurA N-terminal domain; Region: SurA_N_3; cl07813 585395001366 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 585395001367 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 585395001368 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 585395001369 active site 585395001370 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 585395001371 Ligand Binding Site [chemical binding]; other site 585395001372 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 585395001373 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 585395001374 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 585395001375 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 585395001376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395001377 active site 585395001378 motif I; other site 585395001379 motif II; other site 585395001380 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 585395001381 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585395001382 putative DNA binding site [nucleotide binding]; other site 585395001383 putative Zn2+ binding site [ion binding]; other site 585395001384 AsnC family; Region: AsnC_trans_reg; pfam01037 585395001385 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585395001386 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 585395001387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395001388 Walker A/P-loop; other site 585395001389 ATP binding site [chemical binding]; other site 585395001390 Q-loop/lid; other site 585395001391 ABC transporter signature motif; other site 585395001392 Walker B; other site 585395001393 D-loop; other site 585395001394 H-loop/switch region; other site 585395001395 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 585395001396 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585395001397 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 585395001398 Walker A/P-loop; other site 585395001399 ATP binding site [chemical binding]; other site 585395001400 Q-loop/lid; other site 585395001401 ABC transporter signature motif; other site 585395001402 Walker B; other site 585395001403 D-loop; other site 585395001404 H-loop/switch region; other site 585395001405 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 585395001406 Nitrogen regulatory protein P-II; Region: P-II; smart00938 585395001407 ammonium transporter; Provisional; Region: PRK10666 585395001408 acyl-CoA thioesterase II; Provisional; Region: PRK10526 585395001409 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 585395001410 active site 585395001411 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 585395001412 catalytic triad [active] 585395001413 dimer interface [polypeptide binding]; other site 585395001414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 585395001415 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 585395001416 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585395001417 DNA binding site [nucleotide binding] 585395001418 active site 585395001419 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 585395001420 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 585395001421 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585395001422 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395001423 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 585395001424 maltose O-acetyltransferase; Provisional; Region: PRK10092 585395001425 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 585395001426 active site 585395001427 substrate binding site [chemical binding]; other site 585395001428 trimer interface [polypeptide binding]; other site 585395001429 CoA binding site [chemical binding]; other site 585395001430 gene expression modulator; Provisional; Region: PRK10945 585395001431 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 585395001432 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 585395001433 Protein export membrane protein; Region: SecD_SecF; cl14618 585395001434 Protein export membrane protein; Region: SecD_SecF; cl14618 585395001435 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 585395001436 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395001437 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395001438 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 585395001439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585395001440 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 585395001441 hypothetical protein; Provisional; Region: PRK11281 585395001442 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 585395001443 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 585395001444 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585395001445 hypothetical protein; Provisional; Region: PRK11038 585395001446 primosomal replication protein N''; Provisional; Region: PRK10093 585395001447 hypothetical protein; Provisional; Region: PRK10527 585395001448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585395001449 active site 585395001450 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 585395001451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395001452 Walker A motif; other site 585395001453 ATP binding site [chemical binding]; other site 585395001454 Walker B motif; other site 585395001455 DNA polymerase III subunit delta'; Validated; Region: PRK08485 585395001456 arginine finger; other site 585395001457 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 585395001458 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 585395001459 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 585395001460 hypothetical protein; Validated; Region: PRK00153 585395001461 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 585395001462 RecR protein; Region: RecR; pfam02132 585395001463 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 585395001464 putative active site [active] 585395001465 putative metal-binding site [ion binding]; other site 585395001466 tetramer interface [polypeptide binding]; other site 585395001467 heat shock protein 90; Provisional; Region: PRK05218 585395001468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395001469 ATP binding site [chemical binding]; other site 585395001470 Mg2+ binding site [ion binding]; other site 585395001471 G-X-G motif; other site 585395001472 adenylate kinase; Reviewed; Region: adk; PRK00279 585395001473 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 585395001474 AMP-binding site [chemical binding]; other site 585395001475 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 585395001476 ferrochelatase; Region: hemH; TIGR00109 585395001477 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 585395001478 C-terminal domain interface [polypeptide binding]; other site 585395001479 active site 585395001480 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 585395001481 active site 585395001482 N-terminal domain interface [polypeptide binding]; other site 585395001483 acetyl esterase; Provisional; Region: PRK10162 585395001484 inosine/guanosine kinase; Provisional; Region: PRK15074 585395001485 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585395001486 putative cation:proton antiport protein; Provisional; Region: PRK10669 585395001487 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 585395001488 TrkA-N domain; Region: TrkA_N; pfam02254 585395001489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395001490 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585395001491 putative substrate translocation pore; other site 585395001492 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 585395001493 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 585395001494 active site 585395001495 metal binding site [ion binding]; metal-binding site 585395001496 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585395001497 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 585395001498 putative deacylase active site [active] 585395001499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 585395001500 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 585395001501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395001502 non-specific DNA binding site [nucleotide binding]; other site 585395001503 salt bridge; other site 585395001504 sequence-specific DNA binding site [nucleotide binding]; other site 585395001505 copper exporting ATPase; Provisional; Region: copA; PRK10671 585395001506 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585395001507 metal-binding site [ion binding] 585395001508 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585395001509 metal-binding site [ion binding] 585395001510 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585395001511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395001512 motif II; other site 585395001513 glutaminase; Reviewed; Region: PRK12356 585395001514 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 585395001515 amino acid transporter; Region: 2A0306; TIGR00909 585395001516 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 585395001517 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 585395001518 DNA binding residues [nucleotide binding] 585395001519 dimer interface [polypeptide binding]; other site 585395001520 copper binding site [ion binding]; other site 585395001521 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 585395001522 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 585395001523 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 585395001524 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 585395001525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395001526 Walker A/P-loop; other site 585395001527 ATP binding site [chemical binding]; other site 585395001528 Q-loop/lid; other site 585395001529 ABC transporter signature motif; other site 585395001530 Walker B; other site 585395001531 D-loop; other site 585395001532 H-loop/switch region; other site 585395001533 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 585395001534 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 585395001535 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 585395001536 oxidoreductase; Provisional; Region: PRK08017 585395001537 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 585395001538 NADP binding site [chemical binding]; other site 585395001539 active site 585395001540 steroid binding site; other site 585395001541 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 585395001542 active site 585395001543 catalytic triad [active] 585395001544 oxyanion hole [active] 585395001545 switch loop; other site 585395001546 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 585395001547 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585395001548 Walker A/P-loop; other site 585395001549 ATP binding site [chemical binding]; other site 585395001550 Q-loop/lid; other site 585395001551 ABC transporter signature motif; other site 585395001552 Walker B; other site 585395001553 D-loop; other site 585395001554 H-loop/switch region; other site 585395001555 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 585395001556 FtsX-like permease family; Region: FtsX; pfam02687 585395001557 FtsX-like permease family; Region: FtsX; pfam02687 585395001558 RhsD, RhsD core protein with extension, C-terminal part, truncated 585395001559 hypothetical protein; Provisional; Region: PRK14710 585395001560 eIF3G domain found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins; Region: eIF3G; cl13749 585395001561 Winged helix-turn helix; Region: HTH_29; pfam13551 585395001562 Helix-turn-helix domain; Region: HTH_28; pfam13518 585395001563 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 585395001564 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 585395001565 active site residue [active] 585395001566 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 585395001567 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395001568 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585395001569 dimerization interface [polypeptide binding]; other site 585395001570 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 585395001571 ureidoglycolate hydrolase; Provisional; Region: PRK03606 585395001572 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 585395001573 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585395001574 Bacterial transcriptional regulator; Region: IclR; pfam01614 585395001575 glyoxylate carboligase; Provisional; Region: PRK11269 585395001576 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585395001577 PYR/PP interface [polypeptide binding]; other site 585395001578 dimer interface [polypeptide binding]; other site 585395001579 TPP binding site [chemical binding]; other site 585395001580 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585395001581 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 585395001582 TPP-binding site [chemical binding]; other site 585395001583 hydroxypyruvate isomerase; Provisional; Region: PRK09997 585395001584 tartronate semialdehyde reductase; Provisional; Region: PRK15059 585395001585 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585395001586 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 585395001587 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 585395001588 Na binding site [ion binding]; other site 585395001589 substrate binding site [chemical binding]; other site 585395001590 allantoinase; Provisional; Region: PRK08044 585395001591 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 585395001592 active site 585395001593 putative uracil/xanthine transporter; Provisional; Region: PRK11412 585395001594 glycerate kinase II; Provisional; Region: PRK09932 585395001595 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 585395001596 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 585395001597 Cupin domain; Region: Cupin_2; cl17218 585395001598 allantoate amidohydrolase; Region: AllC; TIGR03176 585395001599 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 585395001600 active site 585395001601 metal binding site [ion binding]; metal-binding site 585395001602 dimer interface [polypeptide binding]; other site 585395001603 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 585395001604 membrane protein FdrA; Validated; Region: PRK06091 585395001605 CoA binding domain; Region: CoA_binding; pfam02629 585395001606 CoA-ligase; Region: Ligase_CoA; pfam00549 585395001607 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 585395001608 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 585395001609 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 585395001610 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585395001611 putative substrate binding site [chemical binding]; other site 585395001612 nucleotide binding site [chemical binding]; other site 585395001613 nucleotide binding site [chemical binding]; other site 585395001614 homodimer interface [polypeptide binding]; other site 585395001615 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 585395001616 ATP-grasp domain; Region: ATP-grasp; pfam02222 585395001617 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 585395001618 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 585395001619 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585395001620 putative active site [active] 585395001621 putative metal binding site [ion binding]; other site 585395001622 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 585395001623 substrate binding site [chemical binding]; other site 585395001624 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 585395001625 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 585395001626 active site 585395001627 HIGH motif; other site 585395001628 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 585395001629 KMSKS motif; other site 585395001630 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 585395001631 tRNA binding surface [nucleotide binding]; other site 585395001632 anticodon binding site; other site 585395001633 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 585395001634 ribosome-associated protein; Provisional; Region: PRK11507 585395001635 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 585395001636 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 585395001637 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 585395001638 homodimer interface [polypeptide binding]; other site 585395001639 NADP binding site [chemical binding]; other site 585395001640 substrate binding site [chemical binding]; other site 585395001641 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 585395001642 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 585395001643 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585395001644 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585395001645 outer membrane usher protein FimD; Provisional; Region: PRK15198 585395001646 PapC N-terminal domain; Region: PapC_N; pfam13954 585395001647 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585395001648 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 585395001649 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 585395001650 transcriptional regulator FimZ; Provisional; Region: PRK09935 585395001651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395001652 active site 585395001653 phosphorylation site [posttranslational modification] 585395001654 intermolecular recognition site; other site 585395001655 dimerization interface [polypeptide binding]; other site 585395001656 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395001657 DNA binding residues [nucleotide binding] 585395001658 dimerization interface [polypeptide binding]; other site 585395001659 Prophage ECO103_P01, lambda-like phage 585395001660 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 585395001661 Int/Topo IB signature motif; other site 585395001662 Helix-turn-helix domain; Region: HTH_17; pfam12728 585395001663 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 585395001664 Uncharacterized conserved protein [Function unknown]; Region: COG5532 585395001665 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585395001666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395001667 sequence-specific DNA binding site [nucleotide binding]; other site 585395001668 salt bridge; other site 585395001669 Predicted transcriptional regulator [Transcription]; Region: COG2932 585395001670 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585395001671 Catalytic site [active] 585395001672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395001673 non-specific DNA binding site [nucleotide binding]; other site 585395001674 salt bridge; other site 585395001675 sequence-specific DNA binding site [nucleotide binding]; other site 585395001676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395001677 DNA-binding site [nucleotide binding]; DNA binding site 585395001678 PerC transcriptional activator; Region: PerC; pfam06069 585395001679 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 585395001680 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 585395001681 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 585395001682 KilA-N domain; Region: KilA-N; pfam04383 585395001683 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585395001684 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585395001685 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585395001686 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585395001687 trimer interface [polypeptide binding]; other site 585395001688 eyelet of channel; other site 585395001689 Lysis protein S; Region: Lysis_S; pfam04971 585395001690 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585395001691 catalytic residues [active] 585395001692 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585395001693 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585395001694 Bor protein; Region: Lambda_Bor; pfam06291 585395001695 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 585395001696 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 585395001697 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 585395001698 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585395001699 gpW; Region: gpW; pfam02831 585395001700 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585395001701 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585395001702 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 585395001703 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 585395001704 tandem repeat interface [polypeptide binding]; other site 585395001705 oligomer interface [polypeptide binding]; other site 585395001706 active site residues [active] 585395001707 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585395001708 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585395001709 DNA packaging protein FI; Region: Packaging_FI; pfam14000 585395001710 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 585395001711 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585395001712 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585395001713 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585395001714 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585395001715 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 585395001716 Minor tail protein T; Region: Phage_tail_T; pfam06223 585395001717 Prophage ECO103_P01; predicted tail length tape measure protein, N-terminal fragment 585395001718 Prophage ECO103_P01; predicted tail length tape measure protein, C-terminal part 585395001719 Phage-related protein [Function unknown]; Region: COG4718 585395001720 Phage-related protein [Function unknown]; Region: gp18; COG4672 585395001721 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585395001722 MPN+ (JAMM) motif; other site 585395001723 Zinc-binding site [ion binding]; other site 585395001724 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585395001725 NlpC/P60 family; Region: NLPC_P60; cl17555 585395001726 Phage-related protein, tail component [Function unknown]; Region: COG4723 585395001727 Phage-related protein, tail component [Function unknown]; Region: COG4733 585395001728 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585395001729 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585395001730 Fibronectin type III protein; Region: DUF3672; pfam12421 585395001731 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585395001732 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585395001733 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585395001734 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585395001735 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585395001736 Phage Tail Collar Domain; Region: Collar; pfam07484 585395001737 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585395001738 multiple promoter invertase; Provisional; Region: mpi; PRK13413 585395001739 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 585395001740 catalytic residues [active] 585395001741 catalytic nucleophile [active] 585395001742 Presynaptic Site I dimer interface [polypeptide binding]; other site 585395001743 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 585395001744 Synaptic Flat tetramer interface [polypeptide binding]; other site 585395001745 Synaptic Site I dimer interface [polypeptide binding]; other site 585395001746 DNA binding site [nucleotide binding] 585395001747 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 585395001748 DNA-binding interface [nucleotide binding]; DNA binding site 585395001749 Methyltransferase domain; Region: Methyltransf_12; pfam08242 585395001750 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585395001751 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 585395001752 TAP-like protein; Region: Abhydrolase_4; pfam08386 585395001753 outer membrane protease; Reviewed; Region: PRK10993 585395001754 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585395001755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395001756 hypothetical protein; Provisional; Region: PRK09936 585395001757 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 585395001758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585395001759 TPR motif; other site 585395001760 binding surface 585395001761 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 585395001762 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 585395001763 active site 585395001764 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 585395001765 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 585395001766 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 585395001767 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585395001768 Transposase [DNA replication, recombination, and repair]; Region: COG5433 585395001769 Transposase [DNA replication, recombination, and repair]; Region: COG5433 585395001770 RhsK, RhsK core protein, N-terminal fragment 585395001771 Uncharacterized conserved protein [Function unknown]; Region: COG5435 585395001772 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 585395001773 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585395001774 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585395001775 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585395001776 sensor kinase CusS; Provisional; Region: PRK09835 585395001777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585395001778 dimerization interface [polypeptide binding]; other site 585395001779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395001780 dimer interface [polypeptide binding]; other site 585395001781 phosphorylation site [posttranslational modification] 585395001782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395001783 ATP binding site [chemical binding]; other site 585395001784 Mg2+ binding site [ion binding]; other site 585395001785 G-X-G motif; other site 585395001786 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 585395001787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395001788 active site 585395001789 phosphorylation site [posttranslational modification] 585395001790 intermolecular recognition site; other site 585395001791 dimerization interface [polypeptide binding]; other site 585395001792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395001793 DNA binding site [nucleotide binding] 585395001794 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 585395001795 periplasmic copper-binding protein; Provisional; Region: PRK09838 585395001796 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 585395001797 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395001798 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 585395001799 phenylalanine transporter; Provisional; Region: PRK10249 585395001800 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 585395001801 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585395001802 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 585395001803 dimer interface [polypeptide binding]; other site 585395001804 FMN binding site [chemical binding]; other site 585395001805 hypothetical protein; Provisional; Region: PRK10250 585395001806 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 585395001807 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 585395001808 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 585395001809 Hok/gef family; Region: HOK_GEF; pfam01848 585395001810 Hok/gef family; Region: HOK_GEF; pfam01848 585395001811 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 585395001812 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 585395001813 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 585395001814 outer membrane receptor FepA; Provisional; Region: PRK13524 585395001815 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585395001816 N-terminal plug; other site 585395001817 ligand-binding site [chemical binding]; other site 585395001818 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 585395001819 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 585395001820 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585395001821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 585395001822 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 585395001823 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 585395001824 acyl-activating enzyme (AAE) consensus motif; other site 585395001825 AMP binding site [chemical binding]; other site 585395001826 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585395001827 LPS O-antigen length regulator; Provisional; Region: PRK10381 585395001828 Chain length determinant protein; Region: Wzz; pfam02706 585395001829 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585395001830 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 585395001831 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585395001832 Walker A/P-loop; other site 585395001833 ATP binding site [chemical binding]; other site 585395001834 Q-loop/lid; other site 585395001835 ABC transporter signature motif; other site 585395001836 Walker B; other site 585395001837 D-loop; other site 585395001838 H-loop/switch region; other site 585395001839 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 585395001840 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585395001841 ABC-ATPase subunit interface; other site 585395001842 dimer interface [polypeptide binding]; other site 585395001843 putative PBP binding regions; other site 585395001844 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585395001845 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585395001846 ABC-ATPase subunit interface; other site 585395001847 dimer interface [polypeptide binding]; other site 585395001848 putative PBP binding regions; other site 585395001849 enterobactin exporter EntS; Provisional; Region: PRK10489 585395001850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395001851 putative substrate translocation pore; other site 585395001852 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 585395001853 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 585395001854 siderophore binding site; other site 585395001855 isochorismate synthase EntC; Provisional; Region: PRK15016 585395001856 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 585395001857 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 585395001858 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 585395001859 acyl-activating enzyme (AAE) consensus motif; other site 585395001860 active site 585395001861 AMP binding site [chemical binding]; other site 585395001862 substrate binding site [chemical binding]; other site 585395001863 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 585395001864 hydrophobic substrate binding pocket; other site 585395001865 Isochorismatase family; Region: Isochorismatase; pfam00857 585395001866 active site 585395001867 conserved cis-peptide bond; other site 585395001868 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 585395001869 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 585395001870 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 585395001871 putative NAD(P) binding site [chemical binding]; other site 585395001872 active site 585395001873 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585395001874 CoenzymeA binding site [chemical binding]; other site 585395001875 subunit interaction site [polypeptide binding]; other site 585395001876 PHB binding site; other site 585395001877 carbon starvation protein A; Provisional; Region: PRK15015 585395001878 Carbon starvation protein CstA; Region: CstA; pfam02554 585395001879 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 585395001880 Uncharacterized small protein [Function unknown]; Region: COG2879 585395001881 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 585395001882 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 585395001883 putative active site [active] 585395001884 metal binding site [ion binding]; metal-binding site 585395001885 methionine aminotransferase; Validated; Region: PRK09082 585395001886 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585395001887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395001888 homodimer interface [polypeptide binding]; other site 585395001889 catalytic residue [active] 585395001890 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 585395001891 ParB-like nuclease domain; Region: ParBc; pfam02195 585395001892 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 585395001893 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585395001894 Active Sites [active] 585395001895 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 585395001896 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 585395001897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395001898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585395001899 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 585395001900 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 585395001901 dimerization domain [polypeptide binding]; other site 585395001902 dimer interface [polypeptide binding]; other site 585395001903 catalytic residues [active] 585395001904 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 585395001905 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 585395001906 dimer interface [polypeptide binding]; other site 585395001907 decamer (pentamer of dimers) interface [polypeptide binding]; other site 585395001908 catalytic triad [active] 585395001909 peroxidatic and resolving cysteines [active] 585395001910 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 585395001911 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 585395001912 catalytic residue [active] 585395001913 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 585395001914 catalytic residues [active] 585395001915 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585395001916 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395001917 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585395001918 Ligand Binding Site [chemical binding]; other site 585395001919 predicted oxidoreductase, Zn-dependent and NAD(P)-binding, N-terminal part 585395001920 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 585395001921 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585395001922 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 585395001923 B1 nucleotide binding pocket [chemical binding]; other site 585395001924 B2 nucleotide binding pocket [chemical binding]; other site 585395001925 CAS motifs; other site 585395001926 active site 585395001927 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585395001928 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585395001929 transmembrane helices; other site 585395001930 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 585395001931 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 585395001932 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 585395001933 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 585395001934 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 585395001935 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 585395001936 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 585395001937 putative active site [active] 585395001938 (T/H)XGH motif; other site 585395001939 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 585395001940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585395001941 putative active site [active] 585395001942 heme pocket [chemical binding]; other site 585395001943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395001944 ATP binding site [chemical binding]; other site 585395001945 Mg2+ binding site [ion binding]; other site 585395001946 G-X-G motif; other site 585395001947 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 585395001948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395001949 active site 585395001950 phosphorylation site [posttranslational modification] 585395001951 intermolecular recognition site; other site 585395001952 dimerization interface [polypeptide binding]; other site 585395001953 Transcriptional regulator; Region: CitT; pfam12431 585395001954 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 585395001955 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 585395001956 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 585395001957 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585395001958 DNA-binding site [nucleotide binding]; DNA binding site 585395001959 RNA-binding motif; other site 585395001960 chromosome condensation membrane protein; Provisional; Region: PRK14196 585395001961 Predicted amidohydrolase [General function prediction only]; Region: COG0388 585395001962 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 585395001963 putative active site [active] 585395001964 catalytic triad [active] 585395001965 putative dimer interface [polypeptide binding]; other site 585395001966 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 585395001967 lipoyl synthase; Provisional; Region: PRK05481 585395001968 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395001969 FeS/SAM binding site; other site 585395001970 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 585395001971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395001972 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 585395001973 substrate binding pocket [chemical binding]; other site 585395001974 dimerization interface [polypeptide binding]; other site 585395001975 lipoate-protein ligase B; Provisional; Region: PRK14342 585395001976 hypothetical protein; Provisional; Region: PRK04998 585395001977 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 585395001978 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585395001979 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 585395001980 rare lipoprotein A; Provisional; Region: PRK10672 585395001981 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 585395001982 Sporulation related domain; Region: SPOR; pfam05036 585395001983 cell wall shape-determining protein; Provisional; Region: PRK10794 585395001984 penicillin-binding protein 2; Provisional; Region: PRK10795 585395001985 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 585395001986 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 585395001987 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 585395001988 ribosome-associated protein; Provisional; Region: PRK11538 585395001989 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585395001990 catalytic core [active] 585395001991 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 585395001992 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 585395001993 active site 585395001994 (T/H)XGH motif; other site 585395001995 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 585395001996 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 585395001997 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 585395001998 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 585395001999 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 585395002000 HIGH motif; other site 585395002001 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 585395002002 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585395002003 active site 585395002004 KMSKS motif; other site 585395002005 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 585395002006 tRNA binding surface [nucleotide binding]; other site 585395002007 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 585395002008 hypothetical protein; Provisional; Region: PRK11032 585395002009 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 585395002010 Sel1-like repeats; Region: SEL1; smart00671 585395002011 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585395002012 Sel1-like repeats; Region: SEL1; smart00671 585395002013 Sel1-like repeats; Region: SEL1; smart00671 585395002014 Sel1-like repeats; Region: SEL1; smart00671 585395002015 Sel1-like repeats; Region: SEL1; smart00671 585395002016 Sel1-like repeats; Region: SEL1; smart00671 585395002017 Sel1-like repeats; Region: SEL1; smart00671 585395002018 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 585395002019 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 585395002020 HSP70 interaction site [polypeptide binding]; other site 585395002021 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585395002022 Sel1-like repeats; Region: SEL1; smart00671 585395002023 Sel1-like repeats; Region: SEL1; smart00671 585395002024 Sel1-like repeats; Region: SEL1; smart00671 585395002025 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 585395002026 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 585395002027 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 585395002028 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 585395002029 nucleotide binding site [chemical binding]; other site 585395002030 putative NEF/HSP70 interaction site [polypeptide binding]; other site 585395002031 SBD interface [polypeptide binding]; other site 585395002032 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585395002033 active site 585395002034 tetramer interface [polypeptide binding]; other site 585395002035 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 585395002036 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585395002037 Walker A/P-loop; other site 585395002038 ATP binding site [chemical binding]; other site 585395002039 Q-loop/lid; other site 585395002040 ABC transporter signature motif; other site 585395002041 Walker B; other site 585395002042 D-loop; other site 585395002043 H-loop/switch region; other site 585395002044 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585395002045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395002046 dimer interface [polypeptide binding]; other site 585395002047 conserved gate region; other site 585395002048 putative PBP binding loops; other site 585395002049 ABC-ATPase subunit interface; other site 585395002050 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585395002051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395002052 dimer interface [polypeptide binding]; other site 585395002053 conserved gate region; other site 585395002054 putative PBP binding loops; other site 585395002055 ABC-ATPase subunit interface; other site 585395002056 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 585395002057 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395002058 substrate binding pocket [chemical binding]; other site 585395002059 membrane-bound complex binding site; other site 585395002060 hinge residues; other site 585395002061 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 585395002062 Uncharacterized conserved protein [Function unknown]; Region: COG3391 585395002063 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 585395002064 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 585395002065 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 585395002066 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 585395002067 putative active site [active] 585395002068 catalytic triad [active] 585395002069 putative dimer interface [polypeptide binding]; other site 585395002070 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 585395002071 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585395002072 Transporter associated domain; Region: CorC_HlyC; smart01091 585395002073 metal-binding heat shock protein; Provisional; Region: PRK00016 585395002074 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 585395002075 PhoH-like protein; Region: PhoH; pfam02562 585395002076 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 585395002077 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 585395002078 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395002079 FeS/SAM binding site; other site 585395002080 TRAM domain; Region: TRAM; pfam01938 585395002081 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 585395002082 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 585395002083 asparagine synthetase B; Provisional; Region: asnB; PRK09431 585395002084 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 585395002085 active site 585395002086 dimer interface [polypeptide binding]; other site 585395002087 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 585395002088 Ligand Binding Site [chemical binding]; other site 585395002089 Molecular Tunnel; other site 585395002090 UMP phosphatase; Provisional; Region: PRK10444 585395002091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395002092 active site 585395002093 motif I; other site 585395002094 motif II; other site 585395002095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395002096 MarR family; Region: MarR; pfam01047 585395002097 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585395002098 ROK family; Region: ROK; pfam00480 585395002099 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 585395002100 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 585395002101 active site 585395002102 dimer interface [polypeptide binding]; other site 585395002103 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585395002104 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585395002105 active site 585395002106 trimer interface [polypeptide binding]; other site 585395002107 allosteric site; other site 585395002108 active site lid [active] 585395002109 hexamer (dimer of trimers) interface [polypeptide binding]; other site 585395002110 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 585395002111 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585395002112 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585395002113 active site turn [active] 585395002114 phosphorylation site [posttranslational modification] 585395002115 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585395002116 HPr interaction site; other site 585395002117 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585395002118 active site 585395002119 phosphorylation site [posttranslational modification] 585395002120 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 585395002121 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585395002122 active site 585395002123 HIGH motif; other site 585395002124 nucleotide binding site [chemical binding]; other site 585395002125 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 585395002126 KMSKS motif; other site 585395002127 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 585395002128 outer membrane porin, OprD family; Region: OprD; pfam03573 585395002129 YbfN-like lipoprotein; Region: YbfN; pfam13982 585395002130 ferric uptake regulator; Provisional; Region: fur; PRK09462 585395002131 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 585395002132 metal binding site 2 [ion binding]; metal-binding site 585395002133 putative DNA binding helix; other site 585395002134 metal binding site 1 [ion binding]; metal-binding site 585395002135 dimer interface [polypeptide binding]; other site 585395002136 structural Zn2+ binding site [ion binding]; other site 585395002137 ryhB-regulated fur leader peptide; Provisional; Region: PRK14761 585395002138 flavodoxin FldA; Validated; Region: PRK09267 585395002139 LexA regulated protein; Provisional; Region: PRK11675 585395002140 acyl-CoA esterase; Provisional; Region: PRK10673 585395002141 PGAP1-like protein; Region: PGAP1; pfam07819 585395002142 replication initiation regulator SeqA; Provisional; Region: PRK11187 585395002143 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 585395002144 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 585395002145 active site 585395002146 substrate binding site [chemical binding]; other site 585395002147 metal binding site [ion binding]; metal-binding site 585395002148 putrescine transporter; Provisional; Region: potE; PRK10655 585395002149 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 585395002150 ornithine decarboxylase; Provisional; Region: PRK13578 585395002151 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585395002152 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585395002153 homodimer interface [polypeptide binding]; other site 585395002154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395002155 catalytic residue [active] 585395002156 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585395002157 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 585395002158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395002159 active site 585395002160 phosphorylation site [posttranslational modification] 585395002161 intermolecular recognition site; other site 585395002162 dimerization interface [polypeptide binding]; other site 585395002163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395002164 DNA binding site [nucleotide binding] 585395002165 sensor protein KdpD; Provisional; Region: PRK10490 585395002166 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 585395002167 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 585395002168 Ligand Binding Site [chemical binding]; other site 585395002169 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 585395002170 GAF domain; Region: GAF_3; pfam13492 585395002171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395002172 dimer interface [polypeptide binding]; other site 585395002173 phosphorylation site [posttranslational modification] 585395002174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395002175 ATP binding site [chemical binding]; other site 585395002176 Mg2+ binding site [ion binding]; other site 585395002177 G-X-G motif; other site 585395002178 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 585395002179 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 585395002180 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585395002181 potassium translocating ATPase, subunit A, C-terminal part 585395002182 potassium translocating ATPase, subunit A, N-terminal part 585395002183 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 585395002184 PAAR motif; Region: PAAR_motif; cl15808 585395002185 RHS Repeat; Region: RHS_repeat; pfam05593 585395002186 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585395002187 RHS Repeat; Region: RHS_repeat; pfam05593 585395002188 RHS Repeat; Region: RHS_repeat; pfam05593 585395002189 RHS protein; Region: RHS; pfam03527 585395002190 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585395002191 RhsC, IS677, H repeat-associated protein, N-terminal part 585395002192 RhsC, IS677, H repeat-associated protein, central part 585395002193 hypothetical protein; Provisional; Region: PRK10167 585395002194 Uncharacterized conserved protein [Function unknown]; Region: COG3272 585395002195 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 585395002196 DNA photolyase; Region: DNA_photolyase; pfam00875 585395002197 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 585395002198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395002199 putative substrate translocation pore; other site 585395002200 POT family; Region: PTR2; pfam00854 585395002201 Uncharacterized conserved protein [Function unknown]; Region: COG0327 585395002202 metal-binding protein; Provisional; Region: PRK10799 585395002203 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 585395002204 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 585395002205 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 585395002206 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 585395002207 putative active site [active] 585395002208 endonuclease VIII; Provisional; Region: PRK10445 585395002209 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 585395002210 DNA binding site [nucleotide binding] 585395002211 catalytic residue [active] 585395002212 putative catalytic residues [active] 585395002213 H2TH interface [polypeptide binding]; other site 585395002214 intercalation triad [nucleotide binding]; other site 585395002215 substrate specificity determining residue; other site 585395002216 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 585395002217 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585395002218 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 585395002219 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 585395002220 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 585395002221 Fimbrial protein; Region: Fimbrial; pfam00419 585395002222 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585395002223 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585395002224 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585395002225 outer membrane usher protein, C-terminal part 585395002226 outer membrane usher protein, N-terminal part 585395002227 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585395002228 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 585395002229 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 585395002230 dimer interface [polypeptide binding]; other site 585395002231 active site 585395002232 citrylCoA binding site [chemical binding]; other site 585395002233 NADH binding [chemical binding]; other site 585395002234 cationic pore residues; other site 585395002235 oxalacetate/citrate binding site [chemical binding]; other site 585395002236 coenzyme A binding site [chemical binding]; other site 585395002237 catalytic triad [active] 585395002238 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 585395002239 Iron-sulfur protein interface; other site 585395002240 proximal quinone binding site [chemical binding]; other site 585395002241 SdhD (CybS) interface [polypeptide binding]; other site 585395002242 proximal heme binding site [chemical binding]; other site 585395002243 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 585395002244 SdhC subunit interface [polypeptide binding]; other site 585395002245 proximal heme binding site [chemical binding]; other site 585395002246 cardiolipin binding site; other site 585395002247 Iron-sulfur protein interface; other site 585395002248 proximal quinone binding site [chemical binding]; other site 585395002249 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 585395002250 L-aspartate oxidase; Provisional; Region: PRK06175 585395002251 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585395002252 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 585395002253 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 585395002254 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 585395002255 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 585395002256 TPP-binding site [chemical binding]; other site 585395002257 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 585395002258 dimer interface [polypeptide binding]; other site 585395002259 PYR/PP interface [polypeptide binding]; other site 585395002260 TPP binding site [chemical binding]; other site 585395002261 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 585395002262 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585395002263 E3 interaction surface; other site 585395002264 lipoyl attachment site [posttranslational modification]; other site 585395002265 e3 binding domain; Region: E3_binding; pfam02817 585395002266 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 585395002267 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 585395002268 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 585395002269 CoA-ligase; Region: Ligase_CoA; pfam00549 585395002270 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 585395002271 CoA binding domain; Region: CoA_binding; smart00881 585395002272 CoA-ligase; Region: Ligase_CoA; pfam00549 585395002273 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 585395002274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395002275 DNA-binding site [nucleotide binding]; DNA binding site 585395002276 UTRA domain; Region: UTRA; pfam07702 585395002277 fused 2-O-a-mannosyl-D-glycerate specific PTS enzymes: IIA component/IIB component/IIC component, N-terminal part 585395002278 fused 2-O-a-mannosyl-D-glycerate specific PTS enzymes: IIA component/IIB component/IIC component, C-terminal part 585395002279 alpha-mannosidase; Provisional; Region: PRK09819 585395002280 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 585395002281 active site 585395002282 metal binding site [ion binding]; metal-binding site 585395002283 catalytic site [active] 585395002284 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 585395002285 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 585395002286 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 585395002287 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 585395002288 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 585395002289 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 585395002290 hypothetical protein; Provisional; Region: PRK10588 585395002291 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 585395002292 active site 585395002293 colicin uptake protein TolQ; Provisional; Region: PRK10801 585395002294 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 585395002295 colicin uptake protein TolR; Provisional; Region: PRK11024 585395002296 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 585395002297 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 585395002298 TolA C-terminal; Region: TolA; pfam06519 585395002299 translocation protein TolB; Provisional; Region: tolB; PRK03629 585395002300 TolB amino-terminal domain; Region: TolB_N; pfam04052 585395002301 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585395002302 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585395002303 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585395002304 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 585395002305 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585395002306 ligand binding site [chemical binding]; other site 585395002307 tol-pal system protein YbgF; Provisional; Region: PRK10803 585395002308 Tetratricopeptide repeat; Region: TPR_6; pfam13174 585395002309 Tetratricopeptide repeat; Region: TPR_6; pfam13174 585395002310 quinolinate synthetase; Provisional; Region: PRK09375 585395002311 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 585395002312 zinc transporter ZitB; Provisional; Region: PRK03557 585395002313 YbgS-like protein; Region: YbgS; pfam13985 585395002314 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 585395002315 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585395002316 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585395002317 catalytic core [active] 585395002318 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585395002319 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 585395002320 active site 585395002321 catalytic residues [active] 585395002322 galactokinase; Provisional; Region: PRK05101 585395002323 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 585395002324 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585395002325 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 585395002326 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 585395002327 dimer interface [polypeptide binding]; other site 585395002328 active site 585395002329 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 585395002330 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 585395002331 NAD binding site [chemical binding]; other site 585395002332 homodimer interface [polypeptide binding]; other site 585395002333 active site 585395002334 substrate binding site [chemical binding]; other site 585395002335 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 585395002336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 585395002337 Walker A/P-loop; other site 585395002338 ATP binding site [chemical binding]; other site 585395002339 Q-loop/lid; other site 585395002340 ABC transporter signature motif; other site 585395002341 Walker B; other site 585395002342 D-loop; other site 585395002343 H-loop/switch region; other site 585395002344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395002345 Walker A/P-loop; other site 585395002346 ATP binding site [chemical binding]; other site 585395002347 Q-loop/lid; other site 585395002348 ABC transporter signature motif; other site 585395002349 Walker B; other site 585395002350 D-loop; other site 585395002351 H-loop/switch region; other site 585395002352 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 585395002353 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 585395002354 molybdenum-pterin binding domain; Region: Mop; TIGR00638 585395002355 TOBE domain; Region: TOBE; pfam03459 585395002356 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 585395002357 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 585395002358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395002359 substrate binding pocket [chemical binding]; other site 585395002360 membrane-bound complex binding site; other site 585395002361 hinge residues; other site 585395002362 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 585395002363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395002364 dimer interface [polypeptide binding]; other site 585395002365 conserved gate region; other site 585395002366 putative PBP binding loops; other site 585395002367 ABC-ATPase subunit interface; other site 585395002368 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 585395002369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395002370 Walker A/P-loop; other site 585395002371 ATP binding site [chemical binding]; other site 585395002372 Q-loop/lid; other site 585395002373 ABC transporter signature motif; other site 585395002374 Walker B; other site 585395002375 D-loop; other site 585395002376 H-loop/switch region; other site 585395002377 molybdenum-pterin binding domain; Region: Mop; TIGR00638 585395002378 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 585395002379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395002380 motif II; other site 585395002381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395002382 6-phosphogluconolactonase; Provisional; Region: PRK11028 585395002383 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585395002384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395002385 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 585395002386 putative dimerization interface [polypeptide binding]; other site 585395002387 PrpF protein; Region: PrpF; pfam04303 585395002388 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585395002389 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585395002390 transmembrane helices; other site 585395002391 putative hydratase; Provisional; Region: PRK11413 585395002392 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 585395002393 substrate binding site [chemical binding]; other site 585395002394 ligand binding site [chemical binding]; other site 585395002395 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 585395002396 substrate binding site [chemical binding]; other site 585395002397 acyl-CoA thioesterase; Provisional; Region: PRK10531 585395002398 putative pectinesterase; Region: PLN02432; cl01911 585395002399 Prophage ECO103_P02, lambda-like phage 585395002400 Prophage ECO103_P02; predicted integrase, C-terminal part 585395002401 NINE Protein; Region: NinE; pfam05322 585395002402 NinF protein; Region: NinF; pfam05810 585395002403 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 585395002404 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 585395002405 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585395002406 active site 585395002407 metal binding site [ion binding]; metal-binding site 585395002408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 585395002409 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 585395002410 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 585395002411 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585395002412 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585395002413 Lysis protein S; Region: Lysis_S; pfam04971 585395002414 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585395002415 catalytic residues [active] 585395002416 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585395002417 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585395002418 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585395002419 putative transposase OrfB; Reviewed; Region: PHA02517 585395002420 HTH-like domain; Region: HTH_21; pfam13276 585395002421 Integrase core domain; Region: rve; pfam00665 585395002422 Integrase core domain; Region: rve_3; pfam13683 585395002423 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 585395002424 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585395002425 gpW; Region: gpW; pfam02831 585395002426 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585395002427 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585395002428 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 585395002429 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 585395002430 tandem repeat interface [polypeptide binding]; other site 585395002431 oligomer interface [polypeptide binding]; other site 585395002432 active site residues [active] 585395002433 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585395002434 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585395002435 DNA packaging protein FI; Region: Packaging_FI; pfam14000 585395002436 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 585395002437 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585395002438 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585395002439 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585395002440 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585395002441 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 585395002442 Minor tail protein T; Region: Phage_tail_T; cl05636 585395002443 Phage-related minor tail protein [Function unknown]; Region: COG5281 585395002444 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585395002445 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585395002446 Phage-related protein [Function unknown]; Region: COG4718 585395002447 Phage-related protein [Function unknown]; Region: gp18; COG4672 585395002448 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585395002449 MPN+ (JAMM) motif; other site 585395002450 Zinc-binding site [ion binding]; other site 585395002451 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585395002452 NlpC/P60 family; Region: NLPC_P60; cl17555 585395002453 Phage-related protein, tail component [Function unknown]; Region: COG4723 585395002454 Phage-related protein, tail component [Function unknown]; Region: COG4733 585395002455 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585395002456 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585395002457 Interdomain contacts; other site 585395002458 Cytokine receptor motif; other site 585395002459 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585395002460 Fibronectin type III protein; Region: DUF3672; pfam12421 585395002461 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585395002462 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585395002463 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585395002464 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395002465 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395002466 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 585395002467 type III secretion system protein; Provisional; Region: PRK15384; cl14665 585395002468 Prophage ECO103_P02; T3SS effector NleC-homolog, N-terminal part 585395002469 Prophage ECO103_P02; Cycle-inhibiting factor Cif, non-functional due to frame shift mutations 585395002470 Prophage ECO103_P02; part of site-specific recombinase, phage integrase family 585395002471 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585395002472 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 585395002473 substrate binding site [chemical binding]; other site 585395002474 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 585395002475 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585395002476 inhibitor-cofactor binding pocket; inhibition site 585395002477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395002478 catalytic residue [active] 585395002479 biotin synthase; Provisional; Region: PRK15108 585395002480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395002481 FeS/SAM binding site; other site 585395002482 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 585395002483 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585395002484 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 585395002485 substrate-cofactor binding pocket; other site 585395002486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395002487 catalytic residue [active] 585395002488 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 585395002489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395002490 S-adenosylmethionine binding site [chemical binding]; other site 585395002491 AAA domain; Region: AAA_26; pfam13500 585395002492 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585395002493 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 585395002494 ADP binding site [chemical binding]; other site 585395002495 excinuclease ABC subunit B; Provisional; Region: PRK05298 585395002496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395002497 ATP binding site [chemical binding]; other site 585395002498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395002499 nucleotide binding region [chemical binding]; other site 585395002500 ATP-binding site [chemical binding]; other site 585395002501 Ultra-violet resistance protein B; Region: UvrB; pfam12344 585395002502 UvrB/uvrC motif; Region: UVR; pfam02151 585395002503 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 585395002504 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 585395002505 putative substrate binding pocket [chemical binding]; other site 585395002506 dimer interface [polypeptide binding]; other site 585395002507 phosphate binding site [ion binding]; other site 585395002508 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 585395002509 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395002510 FeS/SAM binding site; other site 585395002511 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 585395002512 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 585395002513 MPT binding site; other site 585395002514 trimer interface [polypeptide binding]; other site 585395002515 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 585395002516 trimer interface [polypeptide binding]; other site 585395002517 dimer interface [polypeptide binding]; other site 585395002518 putative active site [active] 585395002519 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 585395002520 MoaE interaction surface [polypeptide binding]; other site 585395002521 MoeB interaction surface [polypeptide binding]; other site 585395002522 thiocarboxylated glycine; other site 585395002523 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 585395002524 MoaE homodimer interface [polypeptide binding]; other site 585395002525 MoaD interaction [polypeptide binding]; other site 585395002526 active site residues [active] 585395002527 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585395002528 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 585395002529 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585395002530 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 585395002531 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585395002532 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 585395002533 Predicted integral membrane protein [Function unknown]; Region: COG0392 585395002534 cardiolipin synthase 2; Provisional; Region: PRK11263 585395002535 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 585395002536 putative active site [active] 585395002537 catalytic site [active] 585395002538 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 585395002539 putative active site [active] 585395002540 catalytic site [active] 585395002541 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 585395002542 putative catalytic site [active] 585395002543 putative metal binding site [ion binding]; other site 585395002544 putative phosphate binding site [ion binding]; other site 585395002545 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 585395002546 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585395002547 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 585395002548 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585395002549 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 585395002550 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 585395002551 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585395002552 Walker A/P-loop; other site 585395002553 ATP binding site [chemical binding]; other site 585395002554 Q-loop/lid; other site 585395002555 ABC transporter signature motif; other site 585395002556 Walker B; other site 585395002557 D-loop; other site 585395002558 H-loop/switch region; other site 585395002559 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 585395002560 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585395002561 Walker A/P-loop; other site 585395002562 ATP binding site [chemical binding]; other site 585395002563 Q-loop/lid; other site 585395002564 ABC transporter signature motif; other site 585395002565 Walker B; other site 585395002566 D-loop; other site 585395002567 H-loop/switch region; other site 585395002568 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 585395002569 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395002570 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395002571 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 585395002572 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 585395002573 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 585395002574 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585395002575 ATP binding site [chemical binding]; other site 585395002576 Mg++ binding site [ion binding]; other site 585395002577 motif III; other site 585395002578 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395002579 nucleotide binding region [chemical binding]; other site 585395002580 ATP-binding site [chemical binding]; other site 585395002581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 585395002582 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 585395002583 DEAD_2; Region: DEAD_2; pfam06733 585395002584 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 585395002585 glycosyl transferase family protein; Provisional; Region: PRK08136 585395002586 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585395002587 putative dehydrogenase; Provisional; Region: PRK10098 585395002588 hypothetical protein; Provisional; Region: PRK10259 585395002589 hypothetical protein; Provisional; Region: PRK11019 585395002590 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 585395002591 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 585395002592 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585395002593 N-terminal plug; other site 585395002594 ligand-binding site [chemical binding]; other site 585395002595 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585395002596 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 585395002597 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 585395002598 putative mechanosensitive channel protein; Provisional; Region: PRK11465 585395002599 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585395002600 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 585395002601 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585395002602 Walker A/P-loop; other site 585395002603 ATP binding site [chemical binding]; other site 585395002604 Q-loop/lid; other site 585395002605 ABC transporter signature motif; other site 585395002606 Walker B; other site 585395002607 D-loop; other site 585395002608 H-loop/switch region; other site 585395002609 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585395002610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395002611 dimer interface [polypeptide binding]; other site 585395002612 conserved gate region; other site 585395002613 putative PBP binding loops; other site 585395002614 ABC-ATPase subunit interface; other site 585395002615 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 585395002616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395002617 substrate binding pocket [chemical binding]; other site 585395002618 membrane-bound complex binding site; other site 585395002619 hinge residues; other site 585395002620 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 585395002621 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 585395002622 dimerization interface [polypeptide binding]; other site 585395002623 DPS ferroxidase diiron center [ion binding]; other site 585395002624 ion pore; other site 585395002625 threonine and homoserine efflux system; Provisional; Region: PRK10532 585395002626 EamA-like transporter family; Region: EamA; pfam00892 585395002627 outer membrane protein X; Provisional; Region: ompX; PRK09408 585395002628 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 585395002629 Sulfatase; Region: Sulfatase; pfam00884 585395002630 manganese transport regulator MntR; Provisional; Region: PRK11050 585395002631 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 585395002632 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 585395002633 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585395002634 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 585395002635 transmembrane helices; other site 585395002636 L,D-transpeptidase; Provisional; Region: PRK10260 585395002637 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585395002638 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585395002639 DNA methylase; Region: N6_N4_Mtase; pfam01555 585395002640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395002641 S-adenosylmethionine binding site [chemical binding]; other site 585395002642 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 585395002643 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 585395002644 catalytic residues [active] 585395002645 catalytic nucleophile [active] 585395002646 Presynaptic Site I dimer interface [polypeptide binding]; other site 585395002647 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 585395002648 Synaptic Flat tetramer interface [polypeptide binding]; other site 585395002649 Synaptic Site I dimer interface [polypeptide binding]; other site 585395002650 DNA binding site [nucleotide binding] 585395002651 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 585395002652 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 585395002653 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585395002654 active site 585395002655 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585395002656 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395002657 non-specific DNA binding site [nucleotide binding]; other site 585395002658 salt bridge; other site 585395002659 sequence-specific DNA binding site [nucleotide binding]; other site 585395002660 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 585395002661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395002662 Walker A/P-loop; other site 585395002663 ATP binding site [chemical binding]; other site 585395002664 Q-loop/lid; other site 585395002665 ABC transporter signature motif; other site 585395002666 Walker B; other site 585395002667 D-loop; other site 585395002668 H-loop/switch region; other site 585395002669 ABC transporter; Region: ABC_tran_2; pfam12848 585395002670 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585395002671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585395002672 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585395002673 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585395002674 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 585395002675 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 585395002676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395002677 active site 585395002678 motif I; other site 585395002679 motif II; other site 585395002680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395002681 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 585395002682 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 585395002683 dimer interface [polypeptide binding]; other site 585395002684 active site 585395002685 glycine loop; other site 585395002686 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 585395002687 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 585395002688 active site 585395002689 intersubunit interactions; other site 585395002690 catalytic residue [active] 585395002691 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 585395002692 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 585395002693 ATP binding site [chemical binding]; other site 585395002694 substrate interface [chemical binding]; other site 585395002695 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 585395002696 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 585395002697 dimer interface [polypeptide binding]; other site 585395002698 putative functional site; other site 585395002699 putative MPT binding site; other site 585395002700 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 585395002701 catalytic nucleophile [active] 585395002702 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 585395002703 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395002704 Walker A/P-loop; other site 585395002705 ATP binding site [chemical binding]; other site 585395002706 Q-loop/lid; other site 585395002707 ABC transporter signature motif; other site 585395002708 Walker B; other site 585395002709 D-loop; other site 585395002710 H-loop/switch region; other site 585395002711 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585395002712 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395002713 Walker A/P-loop; other site 585395002714 ATP binding site [chemical binding]; other site 585395002715 Q-loop/lid; other site 585395002716 ABC transporter signature motif; other site 585395002717 Walker B; other site 585395002718 D-loop; other site 585395002719 H-loop/switch region; other site 585395002720 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 585395002721 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 585395002722 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 585395002723 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 585395002724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395002725 dimer interface [polypeptide binding]; other site 585395002726 conserved gate region; other site 585395002727 putative PBP binding loops; other site 585395002728 ABC-ATPase subunit interface; other site 585395002729 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 585395002730 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585395002731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395002732 dimer interface [polypeptide binding]; other site 585395002733 conserved gate region; other site 585395002734 putative PBP binding loops; other site 585395002735 ABC-ATPase subunit interface; other site 585395002736 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395002737 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585395002738 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395002739 metal binding site [ion binding]; metal-binding site 585395002740 active site 585395002741 I-site; other site 585395002742 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 585395002743 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 585395002744 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395002745 FeS/SAM binding site; other site 585395002746 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 585395002747 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 585395002748 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 585395002749 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 585395002750 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 585395002751 putative C-terminal domain interface [polypeptide binding]; other site 585395002752 putative GSH binding site (G-site) [chemical binding]; other site 585395002753 putative dimer interface [polypeptide binding]; other site 585395002754 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 585395002755 N-terminal domain interface [polypeptide binding]; other site 585395002756 dimer interface [polypeptide binding]; other site 585395002757 substrate binding pocket (H-site) [chemical binding]; other site 585395002758 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 585395002759 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585395002760 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 585395002761 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 585395002762 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585395002763 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585395002764 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 585395002765 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585395002766 active site 585395002767 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 585395002768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395002769 putative substrate translocation pore; other site 585395002770 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 585395002771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395002772 active site 585395002773 motif I; other site 585395002774 motif II; other site 585395002775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395002776 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 585395002777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395002778 putative substrate translocation pore; other site 585395002779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585395002780 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 585395002781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585395002782 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 585395002783 putative transporter; Provisional; Region: PRK04972 585395002784 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 585395002785 TrkA-C domain; Region: TrkA_C; pfam02080 585395002786 TrkA-C domain; Region: TrkA_C; pfam02080 585395002787 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 585395002788 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 585395002789 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 585395002790 GSH binding site [chemical binding]; other site 585395002791 catalytic residues [active] 585395002792 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 585395002793 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 585395002794 dimer interface [polypeptide binding]; other site 585395002795 FMN binding site [chemical binding]; other site 585395002796 NADPH bind site [chemical binding]; other site 585395002797 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 585395002798 RimK-like ATP-grasp domain; Region: RimK; pfam08443 585395002799 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 585395002800 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 585395002801 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 585395002802 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 585395002803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395002804 Walker A/P-loop; other site 585395002805 ATP binding site [chemical binding]; other site 585395002806 Q-loop/lid; other site 585395002807 ABC transporter signature motif; other site 585395002808 Walker B; other site 585395002809 D-loop; other site 585395002810 H-loop/switch region; other site 585395002811 TOBE domain; Region: TOBE_2; pfam08402 585395002812 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 585395002813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395002814 dimer interface [polypeptide binding]; other site 585395002815 conserved gate region; other site 585395002816 putative PBP binding loops; other site 585395002817 ABC-ATPase subunit interface; other site 585395002818 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585395002819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395002820 dimer interface [polypeptide binding]; other site 585395002821 conserved gate region; other site 585395002822 putative PBP binding loops; other site 585395002823 ABC-ATPase subunit interface; other site 585395002824 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 585395002825 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 585395002826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395002827 S-adenosylmethionine binding site [chemical binding]; other site 585395002828 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 585395002829 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395002830 substrate binding pocket [chemical binding]; other site 585395002831 membrane-bound complex binding site; other site 585395002832 hinge residues; other site 585395002833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395002834 dimer interface [polypeptide binding]; other site 585395002835 conserved gate region; other site 585395002836 putative PBP binding loops; other site 585395002837 ABC-ATPase subunit interface; other site 585395002838 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585395002839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395002840 dimer interface [polypeptide binding]; other site 585395002841 conserved gate region; other site 585395002842 putative PBP binding loops; other site 585395002843 ABC-ATPase subunit interface; other site 585395002844 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 585395002845 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395002846 substrate binding pocket [chemical binding]; other site 585395002847 membrane-bound complex binding site; other site 585395002848 hinge residues; other site 585395002849 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 585395002850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395002851 Walker A/P-loop; other site 585395002852 ATP binding site [chemical binding]; other site 585395002853 Q-loop/lid; other site 585395002854 ABC transporter signature motif; other site 585395002855 Walker B; other site 585395002856 D-loop; other site 585395002857 H-loop/switch region; other site 585395002858 putative lipoprotein; Provisional; Region: PRK10533 585395002859 hypothetical protein; Provisional; Region: PRK02877 585395002860 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 585395002861 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 585395002862 amidase catalytic site [active] 585395002863 Zn binding residues [ion binding]; other site 585395002864 substrate binding site [chemical binding]; other site 585395002865 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585395002866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585395002867 NAD(P) binding site [chemical binding]; other site 585395002868 active site 585395002869 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 585395002870 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 585395002871 putative NAD(P) binding site [chemical binding]; other site 585395002872 putative active site [active] 585395002873 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 585395002874 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 585395002875 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 585395002876 tetramer interface [polypeptide binding]; other site 585395002877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395002878 catalytic residue [active] 585395002879 pyruvate dehydrogenase; Provisional; Region: PRK09124 585395002880 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 585395002881 PYR/PP interface [polypeptide binding]; other site 585395002882 dimer interface [polypeptide binding]; other site 585395002883 tetramer interface [polypeptide binding]; other site 585395002884 TPP binding site [chemical binding]; other site 585395002885 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585395002886 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 585395002887 TPP-binding site [chemical binding]; other site 585395002888 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 585395002889 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 585395002890 FAD binding pocket [chemical binding]; other site 585395002891 FAD binding motif [chemical binding]; other site 585395002892 phosphate binding motif [ion binding]; other site 585395002893 beta-alpha-beta structure motif; other site 585395002894 NAD binding pocket [chemical binding]; other site 585395002895 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585395002896 catalytic loop [active] 585395002897 iron binding site [ion binding]; other site 585395002898 hybrid cluster protein; Provisional; Region: PRK05290 585395002899 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585395002900 ACS interaction site; other site 585395002901 CODH interaction site; other site 585395002902 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 585395002903 hybrid metal cluster; other site 585395002904 Predicted membrane protein [Function unknown]; Region: COG2431 585395002905 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 585395002906 amphipathic channel; other site 585395002907 Asn-Pro-Ala signature motifs; other site 585395002908 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 585395002909 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 585395002910 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 585395002911 putative active site [active] 585395002912 putative metal-binding site [ion binding]; other site 585395002913 Protein of unknown function (DUF535); Region: DUF535; pfam04393 585395002914 macrolide transporter subunit MacA; Provisional; Region: PRK11578 585395002915 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395002916 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395002917 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 585395002918 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585395002919 Walker A/P-loop; other site 585395002920 ATP binding site [chemical binding]; other site 585395002921 Q-loop/lid; other site 585395002922 ABC transporter signature motif; other site 585395002923 Walker B; other site 585395002924 D-loop; other site 585395002925 H-loop/switch region; other site 585395002926 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585395002927 FtsX-like permease family; Region: FtsX; pfam02687 585395002928 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585395002929 DNA-binding site [nucleotide binding]; DNA binding site 585395002930 RNA-binding motif; other site 585395002931 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 585395002932 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 585395002933 Clp amino terminal domain; Region: Clp_N; pfam02861 585395002934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395002935 Walker A motif; other site 585395002936 ATP binding site [chemical binding]; other site 585395002937 Walker B motif; other site 585395002938 arginine finger; other site 585395002939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395002940 Walker A motif; other site 585395002941 ATP binding site [chemical binding]; other site 585395002942 Walker B motif; other site 585395002943 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 585395002944 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 585395002945 rRNA binding site [nucleotide binding]; other site 585395002946 predicted 30S ribosome binding site; other site 585395002947 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 585395002948 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 585395002949 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585395002950 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 585395002951 Walker A/P-loop; other site 585395002952 ATP binding site [chemical binding]; other site 585395002953 Q-loop/lid; other site 585395002954 ABC transporter signature motif; other site 585395002955 Walker B; other site 585395002956 D-loop; other site 585395002957 H-loop/switch region; other site 585395002958 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 585395002959 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585395002960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395002961 Walker A/P-loop; other site 585395002962 ATP binding site [chemical binding]; other site 585395002963 Q-loop/lid; other site 585395002964 ABC transporter signature motif; other site 585395002965 Walker B; other site 585395002966 D-loop; other site 585395002967 H-loop/switch region; other site 585395002968 thioredoxin reductase; Provisional; Region: PRK10262 585395002969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585395002970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395002971 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 585395002972 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585395002973 putative DNA binding site [nucleotide binding]; other site 585395002974 putative Zn2+ binding site [ion binding]; other site 585395002975 AsnC family; Region: AsnC_trans_reg; pfam01037 585395002976 DNA translocase FtsK; Provisional; Region: PRK10263 585395002977 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 585395002978 DNA translocase FtsK; Provisional; Region: PRK10263 585395002979 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 585395002980 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 585395002981 periplasmic chaperone LolA; Region: lolA; TIGR00547 585395002982 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 585395002983 recombination factor protein RarA; Reviewed; Region: PRK13342 585395002984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395002985 Walker A motif; other site 585395002986 ATP binding site [chemical binding]; other site 585395002987 Walker B motif; other site 585395002988 arginine finger; other site 585395002989 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 585395002990 seryl-tRNA synthetase; Provisional; Region: PRK05431 585395002991 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 585395002992 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 585395002993 dimer interface [polypeptide binding]; other site 585395002994 active site 585395002995 motif 1; other site 585395002996 motif 2; other site 585395002997 motif 3; other site 585395002998 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 585395002999 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585395003000 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 585395003001 putative [Fe4-S4] binding site [ion binding]; other site 585395003002 putative molybdopterin cofactor binding site [chemical binding]; other site 585395003003 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 585395003004 putative molybdopterin cofactor binding site; other site 585395003005 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 585395003006 4Fe-4S binding domain; Region: Fer4; pfam00037 585395003007 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 585395003008 Isochorismatase family; Region: Isochorismatase; pfam00857 585395003009 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 585395003010 catalytic triad [active] 585395003011 dimer interface [polypeptide binding]; other site 585395003012 conserved cis-peptide bond; other site 585395003013 putative MFS family transporter protein; Provisional; Region: PRK03633 585395003014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395003015 putative substrate translocation pore; other site 585395003016 Amino acid permease; Region: AA_permease_2; pfam13520 585395003017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585395003018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395003019 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 585395003020 putative effector binding pocket; other site 585395003021 putative dimerization interface [polypeptide binding]; other site 585395003022 hypothetical protein; Provisional; Region: PRK09739 585395003023 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585395003024 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 585395003025 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395003026 FeS/SAM binding site; other site 585395003027 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 585395003028 Pyruvate formate lyase 1; Region: PFL1; cd01678 585395003029 coenzyme A binding site [chemical binding]; other site 585395003030 active site 585395003031 catalytic residues [active] 585395003032 glycine loop; other site 585395003033 formate transporter; Provisional; Region: PRK10805 585395003034 uncharacterized domain; Region: TIGR00702 585395003035 YcaO-like family; Region: YcaO; pfam02624 585395003036 Predicted membrane protein [Function unknown]; Region: COG2323 585395003037 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 585395003038 homodimer interface [polypeptide binding]; other site 585395003039 substrate-cofactor binding pocket; other site 585395003040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395003041 catalytic residue [active] 585395003042 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 585395003043 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 585395003044 hinge; other site 585395003045 active site 585395003046 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 585395003047 cytidylate kinase; Provisional; Region: cmk; PRK00023 585395003048 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 585395003049 CMP-binding site; other site 585395003050 The sites determining sugar specificity; other site 585395003051 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 585395003052 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 585395003053 RNA binding site [nucleotide binding]; other site 585395003054 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 585395003055 RNA binding site [nucleotide binding]; other site 585395003056 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 585395003057 RNA binding site [nucleotide binding]; other site 585395003058 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 585395003059 RNA binding site [nucleotide binding]; other site 585395003060 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 585395003061 RNA binding site [nucleotide binding]; other site 585395003062 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585395003063 IHF dimer interface [polypeptide binding]; other site 585395003064 IHF - DNA interface [nucleotide binding]; other site 585395003065 ComEC family competence protein; Provisional; Region: PRK11539 585395003066 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 585395003067 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 585395003068 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 585395003069 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 585395003070 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585395003071 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 585395003072 Walker A/P-loop; other site 585395003073 ATP binding site [chemical binding]; other site 585395003074 Q-loop/lid; other site 585395003075 ABC transporter signature motif; other site 585395003076 Walker B; other site 585395003077 D-loop; other site 585395003078 H-loop/switch region; other site 585395003079 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 585395003080 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 585395003081 conserved predicted protein, N-terminal part 585395003082 conserved predicted protein, C-terminal part 585395003083 hypothetical protein; Provisional; Region: PRK11827 585395003084 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 585395003085 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 585395003086 Ligand binding site; other site 585395003087 oligomer interface; other site 585395003088 hypothetical protein; Provisional; Region: PRK10593 585395003089 Uncharacterized conserved protein [Function unknown]; Region: COG1434 585395003090 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585395003091 putative active site [active] 585395003092 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585395003093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395003094 S-adenosylmethionine binding site [chemical binding]; other site 585395003095 condesin subunit F; Provisional; Region: PRK05260 585395003096 condesin subunit E; Provisional; Region: PRK05256 585395003097 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 585395003098 MukB N-terminal; Region: MukB; pfam04310 585395003099 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 585395003100 murein L,D-transpeptidase; Provisional; Region: PRK10594 585395003101 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 585395003102 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585395003103 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585395003104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 585395003105 Peptidase M15; Region: Peptidase_M15_3; cl01194 585395003106 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 585395003107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585395003108 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585395003109 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585395003110 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 585395003111 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585395003112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395003113 homodimer interface [polypeptide binding]; other site 585395003114 catalytic residue [active] 585395003115 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585395003116 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585395003117 trimer interface [polypeptide binding]; other site 585395003118 eyelet of channel; other site 585395003119 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 585395003120 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 585395003121 putative dimer interface [polypeptide binding]; other site 585395003122 putative anticodon binding site; other site 585395003123 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 585395003124 homodimer interface [polypeptide binding]; other site 585395003125 motif 1; other site 585395003126 motif 2; other site 585395003127 active site 585395003128 motif 3; other site 585395003129 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 585395003130 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 585395003131 active site 585395003132 aminopeptidase N; Provisional; Region: pepN; PRK14015 585395003133 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 585395003134 active site 585395003135 Zn binding site [ion binding]; other site 585395003136 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 585395003137 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 585395003138 Walker A/P-loop; other site 585395003139 ATP binding site [chemical binding]; other site 585395003140 Q-loop/lid; other site 585395003141 ABC transporter signature motif; other site 585395003142 Walker B; other site 585395003143 D-loop; other site 585395003144 H-loop/switch region; other site 585395003145 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 585395003146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395003147 dimer interface [polypeptide binding]; other site 585395003148 conserved gate region; other site 585395003149 putative PBP binding loops; other site 585395003150 ABC-ATPase subunit interface; other site 585395003151 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 585395003152 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 585395003153 active site 585395003154 dimer interface [polypeptide binding]; other site 585395003155 non-prolyl cis peptide bond; other site 585395003156 insertion regions; other site 585395003157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395003158 substrate binding pocket [chemical binding]; other site 585395003159 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 585395003160 membrane-bound complex binding site; other site 585395003161 hinge residues; other site 585395003162 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 585395003163 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585395003164 Fimbrial protein; Region: Fimbrial; cl01416 585395003165 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585395003166 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585395003167 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585395003168 predicted outer membrane usher protein, N-terminal part 585395003169 predicted outer membrane usher protein, C-terminal part 585395003170 Fimbrial protein; Region: Fimbrial; cl01416 585395003171 Fimbrial protein; Region: Fimbrial; cl01416 585395003172 Fimbrial protein; Region: Fimbrial; cl01416 585395003173 putativi pili assembly chaperone; Provisional; Region: PRK11385 585395003174 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585395003175 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585395003176 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 585395003177 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 585395003178 quinone interaction residues [chemical binding]; other site 585395003179 active site 585395003180 catalytic residues [active] 585395003181 FMN binding site [chemical binding]; other site 585395003182 substrate binding site [chemical binding]; other site 585395003183 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 585395003184 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 585395003185 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 585395003186 MOSC domain; Region: MOSC; pfam03473 585395003187 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585395003188 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585395003189 catalytic loop [active] 585395003190 iron binding site [ion binding]; other site 585395003191 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 585395003192 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 585395003193 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 585395003194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395003195 S-adenosylmethionine binding site [chemical binding]; other site 585395003196 ABC transporter ATPase component; Reviewed; Region: PRK11147 585395003197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395003198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395003199 Walker A/P-loop; other site 585395003200 Walker A/P-loop; other site 585395003201 ATP binding site [chemical binding]; other site 585395003202 ATP binding site [chemical binding]; other site 585395003203 Q-loop/lid; other site 585395003204 Q-loop/lid; other site 585395003205 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585395003206 ABC transporter signature motif; other site 585395003207 Walker B; other site 585395003208 D-loop; other site 585395003209 ABC transporter; Region: ABC_tran_2; pfam12848 585395003210 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585395003211 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 585395003212 Paraquat-inducible protein A; Region: PqiA; pfam04403 585395003213 Paraquat-inducible protein A; Region: PqiA; pfam04403 585395003214 paraquat-inducible protein B; Provisional; Region: PRK10807 585395003215 mce related protein; Region: MCE; pfam02470 585395003216 mce related protein; Region: MCE; pfam02470 585395003217 mce related protein; Region: MCE; pfam02470 585395003218 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 585395003219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 585395003220 Protein of unknown function (DUF330); Region: DUF330; pfam03886 585395003221 ribosome modulation factor; Provisional; Region: PRK14563 585395003222 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 585395003223 active site 1 [active] 585395003224 dimer interface [polypeptide binding]; other site 585395003225 active site 2 [active] 585395003226 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 585395003227 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 585395003228 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 585395003229 outer membrane protein A; Reviewed; Region: PRK10808 585395003230 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 585395003231 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585395003232 ligand binding site [chemical binding]; other site 585395003233 cell division inhibitor SulA; Region: sula; TIGR00623 585395003234 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 585395003235 TfoX C-terminal domain; Region: TfoX_C; pfam04994 585395003236 TIGR01666 family membrane protein; Region: YCCS 585395003237 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 585395003238 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585395003239 Predicted membrane protein [Function unknown]; Region: COG3304 585395003240 Domain of unknown function (DUF307); Region: DUF307; pfam03733 585395003241 Domain of unknown function (DUF307); Region: DUF307; pfam03733 585395003242 DNA helicase IV; Provisional; Region: helD; PRK11054 585395003243 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 585395003244 Part of AAA domain; Region: AAA_19; pfam13245 585395003245 Family description; Region: UvrD_C_2; pfam13538 585395003246 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 585395003247 active site 585395003248 dimer interfaces [polypeptide binding]; other site 585395003249 catalytic residues [active] 585395003250 hypothetical protein; Provisional; Region: PRK03641 585395003251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 585395003252 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 585395003253 heat shock protein HspQ; Provisional; Region: PRK14129 585395003254 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 585395003255 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 585395003256 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 585395003257 putative RNA binding site [nucleotide binding]; other site 585395003258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395003259 S-adenosylmethionine binding site [chemical binding]; other site 585395003260 Acylphosphatase; Region: Acylphosphatase; cl00551 585395003261 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 585395003262 sulfur transfer protein TusE; Provisional; Region: PRK11508 585395003263 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585395003264 YccA-like proteins; Region: YccA_like; cd10433 585395003265 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 585395003266 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585395003267 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 585395003268 hydrogenase 1 large subunit; Provisional; Region: PRK10170 585395003269 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 585395003270 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 585395003271 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 585395003272 putative substrate-binding site; other site 585395003273 nickel binding site [ion binding]; other site 585395003274 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 585395003275 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 585395003276 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 585395003277 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 585395003278 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 585395003279 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 585395003280 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 585395003281 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585395003282 catalytic core [active] 585395003283 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585395003284 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 585395003285 Chain length determinant protein; Region: Wzz; pfam02706 585395003286 Chain length determinant protein; Region: Wzz; cl15801 585395003287 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585395003288 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585395003289 Low molecular weight phosphatase family; Region: LMWPc; cd00115 585395003290 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 585395003291 active site 585395003292 polysaccharide export protein Wza; Provisional; Region: PRK15078 585395003293 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 585395003294 SLBB domain; Region: SLBB; pfam10531 585395003295 SLBB domain; Region: SLBB; pfam10531 585395003296 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 585395003297 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 585395003298 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 585395003299 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585395003300 DNA-binding site [nucleotide binding]; DNA binding site 585395003301 RNA-binding motif; other site 585395003302 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585395003303 DNA-binding site [nucleotide binding]; DNA binding site 585395003304 RNA-binding motif; other site 585395003305 cold shock gene; Provisional; Region: PRK09891 585395003306 GnsA/GnsB family; Region: GnsAB; pfam08178 585395003307 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 585395003308 4Fe-4S binding domain; Region: Fer4_5; pfam12801 585395003309 4Fe-4S binding domain; Region: Fer4_5; pfam12801 585395003310 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585395003311 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 585395003312 HAMP domain; Region: HAMP; pfam00672 585395003313 dimerization interface [polypeptide binding]; other site 585395003314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395003315 dimer interface [polypeptide binding]; other site 585395003316 phosphorylation site [posttranslational modification] 585395003317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395003318 ATP binding site [chemical binding]; other site 585395003319 Mg2+ binding site [ion binding]; other site 585395003320 G-X-G motif; other site 585395003321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395003322 active site 585395003323 phosphorylation site [posttranslational modification] 585395003324 intermolecular recognition site; other site 585395003325 dimerization interface [polypeptide binding]; other site 585395003326 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585395003327 putative binding surface; other site 585395003328 active site 585395003329 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 585395003330 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 585395003331 putative ligand binding site [chemical binding]; other site 585395003332 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 585395003333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395003334 active site 585395003335 phosphorylation site [posttranslational modification] 585395003336 intermolecular recognition site; other site 585395003337 dimerization interface [polypeptide binding]; other site 585395003338 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395003339 DNA binding site [nucleotide binding] 585395003340 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 585395003341 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 585395003342 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 585395003343 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585395003344 molybdopterin cofactor binding site [chemical binding]; other site 585395003345 substrate binding site [chemical binding]; other site 585395003346 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585395003347 molybdopterin cofactor binding site; other site 585395003348 chaperone protein TorD; Validated; Region: torD; PRK04976 585395003349 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 585395003350 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 585395003351 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 585395003352 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585395003353 HSP70 interaction site [polypeptide binding]; other site 585395003354 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 585395003355 substrate binding site [polypeptide binding]; other site 585395003356 dimer interface [polypeptide binding]; other site 585395003357 conserved predicted protein, N-terminal fragment 585395003358 conserved predicted protein, C-terminal fragment 585395003359 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 585395003360 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585395003361 catalytic core [active] 585395003362 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585395003363 hypothetical protein; Provisional; Region: PRK10174 585395003364 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 585395003365 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585395003366 General stress protein [General function prediction only]; Region: GsiB; COG3729 585395003367 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 585395003368 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 585395003369 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 585395003370 putative FMN binding site [chemical binding]; other site 585395003371 pyrimidine utilization protein D; Region: RutD; TIGR03611 585395003372 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585395003373 homotrimer interaction site [polypeptide binding]; other site 585395003374 putative active site [active] 585395003375 Isochorismatase family; Region: Isochorismatase; pfam00857 585395003376 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 585395003377 catalytic triad [active] 585395003378 conserved cis-peptide bond; other site 585395003379 pyrimidine utilization protein A; Region: RutA; TIGR03612 585395003380 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 585395003381 active site 585395003382 dimer interface [polypeptide binding]; other site 585395003383 non-prolyl cis peptide bond; other site 585395003384 insertion regions; other site 585395003385 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585395003386 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 585395003387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585395003388 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 585395003389 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 585395003390 Predicted transcriptional regulator [Transcription]; Region: COG3905 585395003391 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 585395003392 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 585395003393 Glutamate binding site [chemical binding]; other site 585395003394 NAD binding site [chemical binding]; other site 585395003395 catalytic residues [active] 585395003396 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 585395003397 Na binding site [ion binding]; other site 585395003398 FTR1 family protein; Region: TIGR00145 585395003399 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 585395003400 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 585395003401 Imelysin; Region: Peptidase_M75; pfam09375 585395003402 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 585395003403 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 585395003404 conserved predicted protein, N-terminal fragment 585395003405 conserved predicted protein, middle part 585395003406 conserved predicted protein with nucleoside triphosphate hydrolase domain, C-terminal part 585395003407 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 585395003408 N-glycosyltransferase; Provisional; Region: PRK11204 585395003409 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 585395003410 DXD motif; other site 585395003411 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 585395003412 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 585395003413 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 585395003414 putative active site [active] 585395003415 putative metal binding site [ion binding]; other site 585395003416 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 585395003417 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585395003418 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395003419 metal binding site [ion binding]; metal-binding site 585395003420 active site 585395003421 I-site; other site 585395003422 transposase InsF of insertion sequence IS3, C-terminal fragment 585395003423 transposase InsF of insertion sequence IS3, central part 585395003424 Transposase; Region: HTH_Tnp_1; cl17663 585395003425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395003426 predicted (acyl-carrier-protein) S-malonyltransferase, N-terminal part 585395003427 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 585395003428 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 585395003429 putative ligand binding site [chemical binding]; other site 585395003430 NAD binding site [chemical binding]; other site 585395003431 dimerization interface [polypeptide binding]; other site 585395003432 catalytic site [active] 585395003433 putative hydrolase; Validated; Region: PRK09248 585395003434 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 585395003435 active site 585395003436 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 585395003437 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 585395003438 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 585395003439 curli assembly protein CsgF; Provisional; Region: PRK10050 585395003440 curli assembly protein CsgE; Provisional; Region: PRK10386 585395003441 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 585395003442 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395003443 DNA binding residues [nucleotide binding] 585395003444 dimerization interface [polypeptide binding]; other site 585395003445 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 585395003446 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585395003447 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585395003448 major curlin subunit; Provisional; Region: csgA; PRK10051 585395003449 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585395003450 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585395003451 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 585395003452 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585395003453 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 585395003454 putative ADP-ribose binding site [chemical binding]; other site 585395003455 putative active site [active] 585395003456 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 585395003457 PLD-like domain; Region: PLDc_2; pfam13091 585395003458 putative active site [active] 585395003459 catalytic site [active] 585395003460 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 585395003461 PLD-like domain; Region: PLDc_2; pfam13091 585395003462 putative active site [active] 585395003463 catalytic site [active] 585395003464 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 585395003465 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585395003466 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 585395003467 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 585395003468 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 585395003469 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 585395003470 Ligand binding site; other site 585395003471 DXD motif; other site 585395003472 lipoprotein; Provisional; Region: PRK10175 585395003473 secY/secA suppressor protein; Provisional; Region: PRK11467 585395003474 drug efflux system protein MdtG; Provisional; Region: PRK09874 585395003475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395003476 putative substrate translocation pore; other site 585395003477 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585395003478 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585395003479 putative acyl-acceptor binding pocket; other site 585395003480 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 585395003481 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 585395003482 active site residue [active] 585395003483 hypothetical protein; Provisional; Region: PRK03757 585395003484 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 585395003485 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 585395003486 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 585395003487 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585395003488 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 585395003489 DNA damage-inducible protein I; Provisional; Region: PRK10597 585395003490 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 585395003491 active site 585395003492 substrate binding pocket [chemical binding]; other site 585395003493 dimer interface [polypeptide binding]; other site 585395003494 lipoprotein; Provisional; Region: PRK10598 585395003495 glutaredoxin 2; Provisional; Region: PRK10387 585395003496 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 585395003497 C-terminal domain interface [polypeptide binding]; other site 585395003498 GSH binding site (G-site) [chemical binding]; other site 585395003499 catalytic residues [active] 585395003500 putative dimer interface [polypeptide binding]; other site 585395003501 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 585395003502 N-terminal domain interface [polypeptide binding]; other site 585395003503 multidrug resistance protein MdtH; Provisional; Region: PRK11646 585395003504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395003505 putative substrate translocation pore; other site 585395003506 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 585395003507 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 585395003508 hypothetical protein; Provisional; Region: PRK11239 585395003509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 585395003510 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585395003511 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585395003512 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585395003513 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 585395003514 MviN-like protein; Region: MVIN; pfam03023 585395003515 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 585395003516 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 585395003517 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 585395003518 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 585395003519 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 585395003520 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 585395003521 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 585395003522 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 585395003523 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585395003524 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585395003525 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 585395003526 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 585395003527 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 585395003528 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 585395003529 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585395003530 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 585395003531 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585395003532 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 585395003533 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585395003534 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 585395003535 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 585395003536 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585395003537 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585395003538 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 585395003539 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 585395003540 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 585395003541 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 585395003542 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 585395003543 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 585395003544 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 585395003545 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 585395003546 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585395003547 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 585395003548 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 585395003549 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 585395003550 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 585395003551 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 585395003552 homodimer interface [polypeptide binding]; other site 585395003553 oligonucleotide binding site [chemical binding]; other site 585395003554 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 585395003555 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 585395003556 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 585395003557 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585395003558 RNA binding surface [nucleotide binding]; other site 585395003559 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585395003560 active site 585395003561 Maf-like protein; Region: Maf; pfam02545 585395003562 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 585395003563 active site 585395003564 dimer interface [polypeptide binding]; other site 585395003565 hypothetical protein; Provisional; Region: PRK11193 585395003566 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 585395003567 putative phosphate acyltransferase; Provisional; Region: PRK05331 585395003568 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 585395003569 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 585395003570 dimer interface [polypeptide binding]; other site 585395003571 active site 585395003572 CoA binding pocket [chemical binding]; other site 585395003573 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 585395003574 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 585395003575 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 585395003576 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 585395003577 NAD(P) binding site [chemical binding]; other site 585395003578 homotetramer interface [polypeptide binding]; other site 585395003579 homodimer interface [polypeptide binding]; other site 585395003580 active site 585395003581 acyl carrier protein; Provisional; Region: acpP; PRK00982 585395003582 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 585395003583 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 585395003584 dimer interface [polypeptide binding]; other site 585395003585 active site 585395003586 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 585395003587 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 585395003588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395003589 catalytic residue [active] 585395003590 conserved hypothetical protein, YceG family; Region: TIGR00247 585395003591 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 585395003592 dimerization interface [polypeptide binding]; other site 585395003593 thymidylate kinase; Validated; Region: tmk; PRK00698 585395003594 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 585395003595 TMP-binding site; other site 585395003596 ATP-binding site [chemical binding]; other site 585395003597 DNA polymerase III subunit delta'; Validated; Region: PRK07993 585395003598 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 585395003599 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585395003600 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 585395003601 active site 585395003602 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 585395003603 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585395003604 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585395003605 active site turn [active] 585395003606 phosphorylation site [posttranslational modification] 585395003607 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 585395003608 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585395003609 N-terminal plug; other site 585395003610 ligand-binding site [chemical binding]; other site 585395003611 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 585395003612 nucleotide binding site/active site [active] 585395003613 HIT family signature motif; other site 585395003614 catalytic residue [active] 585395003615 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 585395003616 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 585395003617 putative dimer interface [polypeptide binding]; other site 585395003618 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 585395003619 thiamine kinase; Region: ycfN_thiK; TIGR02721 585395003620 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 585395003621 active site 585395003622 substrate binding site [chemical binding]; other site 585395003623 ATP binding site [chemical binding]; other site 585395003624 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 585395003625 beta-hexosaminidase; Provisional; Region: PRK05337 585395003626 hypothetical protein; Provisional; Region: PRK04940 585395003627 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 585395003628 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395003629 hypothetical protein; Provisional; Region: PRK11280 585395003630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585395003631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585395003632 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585395003633 L,D-transpeptidase; Provisional; Region: PRK10260 585395003634 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585395003635 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585395003636 transcription-repair coupling factor; Provisional; Region: PRK10689 585395003637 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 585395003638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395003639 ATP binding site [chemical binding]; other site 585395003640 putative Mg++ binding site [ion binding]; other site 585395003641 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395003642 nucleotide binding region [chemical binding]; other site 585395003643 ATP-binding site [chemical binding]; other site 585395003644 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 585395003645 Predicted membrane protein [Function unknown]; Region: COG4763 585395003646 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585395003647 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 585395003648 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585395003649 FtsX-like permease family; Region: FtsX; pfam02687 585395003650 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 585395003651 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585395003652 Walker A/P-loop; other site 585395003653 ATP binding site [chemical binding]; other site 585395003654 Q-loop/lid; other site 585395003655 ABC transporter signature motif; other site 585395003656 Walker B; other site 585395003657 D-loop; other site 585395003658 H-loop/switch region; other site 585395003659 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 585395003660 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585395003661 FtsX-like permease family; Region: FtsX; pfam02687 585395003662 fructokinase; Reviewed; Region: PRK09557 585395003663 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585395003664 nucleotide binding site [chemical binding]; other site 585395003665 NAD-dependent deacetylase; Provisional; Region: PRK00481 585395003666 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 585395003667 NAD+ binding site [chemical binding]; other site 585395003668 substrate binding site [chemical binding]; other site 585395003669 Zn binding site [ion binding]; other site 585395003670 Repair protein; Region: Repair_PSII; cl01535 585395003671 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 585395003672 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 585395003673 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 585395003674 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585395003675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395003676 dimer interface [polypeptide binding]; other site 585395003677 conserved gate region; other site 585395003678 putative PBP binding loops; other site 585395003679 ABC-ATPase subunit interface; other site 585395003680 Prophage ECO103_P03, lambda-like phage 585395003681 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 585395003682 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585395003683 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 585395003684 dimer interface [polypeptide binding]; other site 585395003685 active site 585395003686 Int/Topo IB signature motif; other site 585395003687 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 585395003688 active site 585395003689 catalytic site [active] 585395003690 substrate binding site [chemical binding]; other site 585395003691 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585395003692 DicB protein; Region: DicB; pfam05358 585395003693 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 585395003694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395003695 sequence-specific DNA binding site [nucleotide binding]; other site 585395003696 salt bridge; other site 585395003697 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585395003698 Helix-turn-helix domain; Region: HTH_36; pfam13730 585395003699 primosomal protein DnaI; Provisional; Region: PRK02854 585395003700 putative replication protein; Provisional; Region: PRK12377 585395003701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395003702 Walker A motif; other site 585395003703 ATP binding site [chemical binding]; other site 585395003704 Walker B motif; other site 585395003705 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 585395003706 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 585395003707 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585395003708 Hok/gef family; Region: HOK_GEF; pfam01848 585395003709 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585395003710 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585395003711 Antitermination protein; Region: Antiterm; pfam03589 585395003712 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585395003713 Prophage ECO103_P03; predicted TciA/TerB-like protein, C-terminal part 585395003714 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 585395003715 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585395003716 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585395003717 Lysis protein S; Region: Lysis_S; pfam04971 585395003718 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585395003719 catalytic residues [active] 585395003720 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585395003721 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 585395003722 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585395003723 active site 585395003724 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 585395003725 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 585395003726 Prophage ECO103_P03; head protein/prohead protease, N-terminal part 585395003727 Prophage ECO103_P03; head protein/prohead protease, C-terminal part 585395003728 Phage-related protein [Function unknown]; Region: COG4695 585395003729 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 585395003730 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 585395003731 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 585395003732 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 585395003733 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 585395003734 Immunoglobulin domain; Region: Ig_3; pfam13927 585395003735 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 585395003736 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 585395003737 Phage-related minor tail protein [Function unknown]; Region: COG5281 585395003738 tape measure domain; Region: tape_meas_nterm; TIGR02675 585395003739 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 585395003740 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585395003741 Phage-related protein [Function unknown]; Region: COG4718 585395003742 Phage-related protein [Function unknown]; Region: gp18; COG4672 585395003743 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585395003744 MPN+ (JAMM) motif; other site 585395003745 Zinc-binding site [ion binding]; other site 585395003746 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585395003747 NlpC/P60 family; Region: NLPC_P60; cl17555 585395003748 Phage-related protein, tail component [Function unknown]; Region: COG4723 585395003749 Phage-related protein, tail component [Function unknown]; Region: COG4733 585395003750 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585395003751 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585395003752 Interdomain contacts; other site 585395003753 Cytokine receptor motif; other site 585395003754 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585395003755 Fibronectin type III protein; Region: DUF3672; pfam12421 585395003756 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585395003757 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585395003758 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585395003759 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395003760 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395003761 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 585395003762 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 585395003763 SopA-like central domain; Region: SopA; pfam13981 585395003764 SopA-like catalytic domain; Region: SopA_C; pfam13979 585395003765 type III secretion protein GogB; Provisional; Region: PRK15386 585395003766 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585395003767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395003768 dimer interface [polypeptide binding]; other site 585395003769 conserved gate region; other site 585395003770 putative PBP binding loops; other site 585395003771 ABC-ATPase subunit interface; other site 585395003772 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 585395003773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395003774 Walker A/P-loop; other site 585395003775 ATP binding site [chemical binding]; other site 585395003776 Q-loop/lid; other site 585395003777 ABC transporter signature motif; other site 585395003778 Walker B; other site 585395003779 D-loop; other site 585395003780 H-loop/switch region; other site 585395003781 TOBE domain; Region: TOBE_2; pfam08402 585395003782 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 585395003783 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 585395003784 metal binding site [ion binding]; metal-binding site 585395003785 dimer interface [polypeptide binding]; other site 585395003786 Uncharacterized conserved protein [Function unknown]; Region: COG2850 585395003787 Cupin-like domain; Region: Cupin_8; pfam13621 585395003788 Prophage ECO103_P04, untypable 585395003789 integrase; Provisional; Region: PRK09692 585395003790 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585395003791 active site 585395003792 Int/Topo IB signature motif; other site 585395003793 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 585395003794 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 585395003795 AAA domain; Region: AAA_25; pfam13481 585395003796 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 585395003797 Walker A motif; other site 585395003798 ATP binding site [chemical binding]; other site 585395003799 Walker B motif; other site 585395003800 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 585395003801 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585395003802 ssDNA binding site [nucleotide binding]; other site 585395003803 dimer interface [polypeptide binding]; other site 585395003804 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585395003805 PerC transcriptional activator; Region: PerC; pfam06069 585395003806 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585395003807 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585395003808 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 585395003809 sensor protein PhoQ; Provisional; Region: PRK10815 585395003810 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 585395003811 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 585395003812 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 585395003813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395003814 ATP binding site [chemical binding]; other site 585395003815 Mg2+ binding site [ion binding]; other site 585395003816 G-X-G motif; other site 585395003817 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 585395003818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395003819 active site 585395003820 phosphorylation site [posttranslational modification] 585395003821 intermolecular recognition site; other site 585395003822 dimerization interface [polypeptide binding]; other site 585395003823 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395003824 DNA binding site [nucleotide binding] 585395003825 adenylosuccinate lyase; Provisional; Region: PRK09285 585395003826 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 585395003827 tetramer interface [polypeptide binding]; other site 585395003828 active site 585395003829 putative lysogenization regulator; Reviewed; Region: PRK00218 585395003830 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 585395003831 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 585395003832 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 585395003833 nudix motif; other site 585395003834 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 585395003835 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 585395003836 probable active site [active] 585395003837 isocitrate dehydrogenase; Validated; Region: PRK07362 585395003838 isocitrate dehydrogenase; Reviewed; Region: PRK07006 585395003839 anti-adapter protein IraM; Provisional; Region: PRK09919 585395003840 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 585395003841 transcriptional regulator MirA; Provisional; Region: PRK15043 585395003842 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 585395003843 DNA binding residues [nucleotide binding] 585395003844 Sensors of blue-light using FAD; Region: BLUF; smart01034 585395003845 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395003846 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 585395003847 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 585395003848 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585395003849 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395003850 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585395003851 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585395003852 Autotransporter beta-domain; Region: Autotransporter; smart00869 585395003853 Autotransporter beta-domain; Region: Autotransporter; smart00869 585395003854 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 585395003855 cell division inhibitor MinD; Provisional; Region: PRK10818 585395003856 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 585395003857 Switch I; other site 585395003858 Switch II; other site 585395003859 septum formation inhibitor; Reviewed; Region: minC; PRK03511 585395003860 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 585395003861 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 585395003862 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 585395003863 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 585395003864 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 585395003865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 585395003866 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 585395003867 hypothetical protein; Provisional; Region: PRK10691 585395003868 hypothetical protein; Provisional; Region: PRK05170 585395003869 hemolysin E, C-terminal part 585395003870 hemolysin E, N-terminal part 585395003871 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585395003872 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585395003873 Catalytic site [active] 585395003874 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 585395003875 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 585395003876 active site 585395003877 DNA binding site [nucleotide binding] 585395003878 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 585395003879 disulfide bond formation protein B; Provisional; Region: PRK01749 585395003880 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585395003881 transmembrane helices; other site 585395003882 fatty acid metabolism regulator; Provisional; Region: PRK04984 585395003883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395003884 DNA-binding site [nucleotide binding]; DNA binding site 585395003885 FadR C-terminal domain; Region: FadR_C; pfam07840 585395003886 SpoVR family protein; Provisional; Region: PRK11767 585395003887 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 585395003888 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 585395003889 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395003890 alanine racemase; Reviewed; Region: dadX; PRK03646 585395003891 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 585395003892 active site 585395003893 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585395003894 substrate binding site [chemical binding]; other site 585395003895 catalytic residues [active] 585395003896 dimer interface [polypeptide binding]; other site 585395003897 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 585395003898 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 585395003899 TrkA-C domain; Region: TrkA_C; pfam02080 585395003900 Transporter associated domain; Region: CorC_HlyC; smart01091 585395003901 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 585395003902 dimer interface [polypeptide binding]; other site 585395003903 catalytic triad [active] 585395003904 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 585395003905 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585395003906 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585395003907 catalytic residue [active] 585395003908 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 585395003909 Flagellar regulator YcgR; Region: YcgR; pfam07317 585395003910 PilZ domain; Region: PilZ; pfam07238 585395003911 hypothetical protein; Provisional; Region: PRK10457 585395003912 trehalase; Provisional; Region: treA; PRK13271 585395003913 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 585395003914 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 585395003915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 585395003916 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585395003917 dimerization domain swap beta strand [polypeptide binding]; other site 585395003918 regulatory protein interface [polypeptide binding]; other site 585395003919 active site 585395003920 regulatory phosphorylation site [posttranslational modification]; other site 585395003921 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585395003922 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585395003923 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 585395003924 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 585395003925 Dak1 domain; Region: Dak1; pfam02733 585395003926 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 585395003927 PAS domain; Region: PAS; smart00091 585395003928 putative active site [active] 585395003929 heme pocket [chemical binding]; other site 585395003930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395003931 Walker A motif; other site 585395003932 ATP binding site [chemical binding]; other site 585395003933 Walker B motif; other site 585395003934 arginine finger; other site 585395003935 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585395003936 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 585395003937 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585395003938 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585395003939 GTP-binding protein YchF; Reviewed; Region: PRK09601 585395003940 YchF GTPase; Region: YchF; cd01900 585395003941 G1 box; other site 585395003942 GTP/Mg2+ binding site [chemical binding]; other site 585395003943 Switch I region; other site 585395003944 G2 box; other site 585395003945 Switch II region; other site 585395003946 G3 box; other site 585395003947 G4 box; other site 585395003948 G5 box; other site 585395003949 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 585395003950 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 585395003951 putative active site [active] 585395003952 catalytic residue [active] 585395003953 hypothetical protein; Provisional; Region: PRK10692 585395003954 putative transporter; Provisional; Region: PRK11660 585395003955 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 585395003956 Sulfate transporter family; Region: Sulfate_transp; pfam00916 585395003957 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 585395003958 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 585395003959 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 585395003960 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585395003961 active site 585395003962 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 585395003963 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585395003964 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 585395003965 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 585395003966 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 585395003967 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 585395003968 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 585395003969 tRNA; other site 585395003970 putative tRNA binding site [nucleotide binding]; other site 585395003971 putative NADP binding site [chemical binding]; other site 585395003972 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 585395003973 peptide chain release factor 1; Validated; Region: prfA; PRK00591 585395003974 This domain is found in peptide chain release factors; Region: PCRF; smart00937 585395003975 RF-1 domain; Region: RF-1; pfam00472 585395003976 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 585395003977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395003978 hypothetical protein; Provisional; Region: PRK10278 585395003979 hypothetical protein; Provisional; Region: PRK10941 585395003980 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 585395003981 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 585395003982 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585395003983 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585395003984 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585395003985 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585395003986 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 585395003987 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585395003988 cation transport regulator; Reviewed; Region: chaB; PRK09582 585395003989 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 585395003990 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 585395003991 putative active site pocket [active] 585395003992 dimerization interface [polypeptide binding]; other site 585395003993 putative catalytic residue [active] 585395003994 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 585395003995 putative invasin; Provisional; Region: PRK10177 585395003996 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585395003997 transcriptional regulator NarL; Provisional; Region: PRK10651 585395003998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395003999 active site 585395004000 phosphorylation site [posttranslational modification] 585395004001 intermolecular recognition site; other site 585395004002 dimerization interface [polypeptide binding]; other site 585395004003 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395004004 DNA binding residues [nucleotide binding] 585395004005 dimerization interface [polypeptide binding]; other site 585395004006 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 585395004007 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 585395004008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585395004009 dimerization interface [polypeptide binding]; other site 585395004010 Histidine kinase; Region: HisKA_3; pfam07730 585395004011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395004012 ATP binding site [chemical binding]; other site 585395004013 Mg2+ binding site [ion binding]; other site 585395004014 G-X-G motif; other site 585395004015 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 585395004016 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 585395004017 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 585395004018 [4Fe-4S] binding site [ion binding]; other site 585395004019 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585395004020 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585395004021 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585395004022 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 585395004023 molybdopterin cofactor binding site; other site 585395004024 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 585395004025 4Fe-4S binding domain; Region: Fer4; cl02805 585395004026 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 585395004027 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 585395004028 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 585395004029 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 585395004030 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 585395004031 putative active site [active] 585395004032 putative substrate binding site [chemical binding]; other site 585395004033 putative cosubstrate binding site; other site 585395004034 catalytic site [active] 585395004035 SEC-C motif; Region: SEC-C; pfam02810 585395004036 hypothetical protein; Provisional; Region: PRK04233 585395004037 hypothetical protein; Provisional; Region: PRK10279 585395004038 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 585395004039 active site 585395004040 nucleophile elbow; other site 585395004041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395004042 active site 585395004043 response regulator of RpoS; Provisional; Region: PRK10693 585395004044 phosphorylation site [posttranslational modification] 585395004045 intermolecular recognition site; other site 585395004046 dimerization interface [polypeptide binding]; other site 585395004047 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 585395004048 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 585395004049 active site 585395004050 tetramer interface; other site 585395004051 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 585395004052 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585395004053 thymidine kinase; Provisional; Region: PRK04296 585395004054 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 585395004055 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 585395004056 putative catalytic cysteine [active] 585395004057 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 585395004058 putative active site [active] 585395004059 metal binding site [ion binding]; metal-binding site 585395004060 hypothetical protein; Provisional; Region: PRK11111 585395004061 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 585395004062 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 585395004063 peptide binding site [polypeptide binding]; other site 585395004064 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 585395004065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395004066 dimer interface [polypeptide binding]; other site 585395004067 conserved gate region; other site 585395004068 putative PBP binding loops; other site 585395004069 ABC-ATPase subunit interface; other site 585395004070 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 585395004071 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585395004072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395004073 dimer interface [polypeptide binding]; other site 585395004074 conserved gate region; other site 585395004075 putative PBP binding loops; other site 585395004076 ABC-ATPase subunit interface; other site 585395004077 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 585395004078 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395004079 Walker A/P-loop; other site 585395004080 ATP binding site [chemical binding]; other site 585395004081 Q-loop/lid; other site 585395004082 ABC transporter signature motif; other site 585395004083 Walker B; other site 585395004084 D-loop; other site 585395004085 H-loop/switch region; other site 585395004086 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585395004087 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 585395004088 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395004089 Walker A/P-loop; other site 585395004090 ATP binding site [chemical binding]; other site 585395004091 Q-loop/lid; other site 585395004092 ABC transporter signature motif; other site 585395004093 Walker B; other site 585395004094 D-loop; other site 585395004095 H-loop/switch region; other site 585395004096 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585395004097 dsDNA-mimic protein; Reviewed; Region: PRK05094 585395004098 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 585395004099 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 585395004100 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 585395004101 putative active site [active] 585395004102 catalytic site [active] 585395004103 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 585395004104 putative active site [active] 585395004105 catalytic site [active] 585395004106 voltage-gated potassium channel; Provisional; Region: PRK10537 585395004107 Ion channel; Region: Ion_trans_2; pfam07885 585395004108 TrkA-N domain; Region: TrkA_N; pfam02254 585395004109 YciI-like protein; Reviewed; Region: PRK11370 585395004110 transport protein TonB; Provisional; Region: PRK10819 585395004111 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 585395004112 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 585395004113 intracellular septation protein A; Reviewed; Region: PRK00259 585395004114 hypothetical protein; Provisional; Region: PRK02868 585395004115 outer membrane protein W; Provisional; Region: PRK10959 585395004116 Prophage ECO103_P05, lambda-like phage 585395004117 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 585395004118 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585395004119 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 585395004120 dimer interface [polypeptide binding]; other site 585395004121 active site 585395004122 Int/Topo IB signature motif; other site 585395004123 exonuclease VIII; Reviewed; Region: PRK09709 585395004124 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 585395004125 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 585395004126 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 585395004127 active site 585395004128 catalytic site [active] 585395004129 substrate binding site [chemical binding]; other site 585395004130 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585395004131 DicB protein; Region: DicB; pfam05358 585395004132 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 585395004133 transcriptional repressor DicA; Reviewed; Region: PRK09706 585395004134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395004135 non-specific DNA binding site [nucleotide binding]; other site 585395004136 salt bridge; other site 585395004137 sequence-specific DNA binding site [nucleotide binding]; other site 585395004138 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 585395004139 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585395004140 Pyocin large subunit [General function prediction only]; Region: COG5529 585395004141 Helix-turn-helix domain; Region: HTH_36; pfam13730 585395004142 primosomal protein DnaI; Provisional; Region: PRK02854 585395004143 Replication protein P; Region: Phage_lambda_P; pfam06992 585395004144 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 585395004145 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 585395004146 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 585395004147 active site 585395004148 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 585395004149 Catalytic domain of Protein Kinases; Region: PKc; cd00180 585395004150 active site 585395004151 ATP binding site [chemical binding]; other site 585395004152 substrate binding site [chemical binding]; other site 585395004153 activation loop (A-loop); other site 585395004154 Hok/gef family; Region: HOK_GEF; pfam01848 585395004155 Hok/gef family; Region: HOK_GEF; pfam01848 585395004156 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585395004157 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585395004158 Antitermination protein; Region: Antiterm; pfam03589 585395004159 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585395004160 MarR family; Region: MarR_2; cl17246 585395004161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395004162 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585395004163 DNA methylase; Region: N6_N4_Mtase; pfam01555 585395004164 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585395004165 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585395004166 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585395004167 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 585395004168 Protein of unknown function (DUF826); Region: DUF826; pfam05696 585395004169 Lysis protein S; Region: Lysis_S; pfam04971 585395004170 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585395004171 catalytic residues [active] 585395004172 Prophage ECO103_P05; predicted antirepressor, N-terminal part 585395004173 Prophage ECO103_P05; predicted antirepressor, C-terminal part 585395004174 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585395004175 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585395004176 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 585395004177 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585395004178 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585395004179 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585395004180 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 585395004181 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 585395004182 oligomer interface [polypeptide binding]; other site 585395004183 active site residues [active] 585395004184 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 585395004185 Uncharacterized conserved protein [Function unknown]; Region: COG5471 585395004186 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 585395004187 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585395004188 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585395004189 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585395004190 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585395004191 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 585395004192 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 585395004193 Phage-related minor tail protein [Function unknown]; Region: COG5281 585395004194 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585395004195 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585395004196 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 585395004197 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585395004198 Phage-related protein [Function unknown]; Region: COG4718 585395004199 Phage-related protein [Function unknown]; Region: gp18; COG4672 585395004200 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585395004201 MPN+ (JAMM) motif; other site 585395004202 Zinc-binding site [ion binding]; other site 585395004203 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585395004204 NlpC/P60 family; Region: NLPC_P60; cl17555 585395004205 Phage-related protein, tail component [Function unknown]; Region: COG4723 585395004206 Phage-related protein, tail component [Function unknown]; Region: COG4733 585395004207 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585395004208 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585395004209 Interdomain contacts; other site 585395004210 Cytokine receptor motif; other site 585395004211 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585395004212 Fibronectin type III protein; Region: DUF3672; pfam12421 585395004213 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585395004214 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585395004215 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395004216 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395004217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585395004218 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585395004219 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585395004220 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 585395004221 Prophage ECO103_P05; T3SS effector OspG-like protein, C-terminal part 585395004222 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 585395004223 Prophage ECO103_P05; outer membrane protein W, C-terminal fragment 585395004224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 585395004225 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 585395004226 dimerization interface [polypeptide binding]; other site 585395004227 metal binding site [ion binding]; metal-binding site 585395004228 General stress protein [General function prediction only]; Region: GsiB; COG3729 585395004229 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 585395004230 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 585395004231 substrate binding site [chemical binding]; other site 585395004232 active site 585395004233 catalytic residues [active] 585395004234 heterodimer interface [polypeptide binding]; other site 585395004235 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 585395004236 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 585395004237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395004238 catalytic residue [active] 585395004239 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 585395004240 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 585395004241 active site 585395004242 ribulose/triose binding site [chemical binding]; other site 585395004243 phosphate binding site [ion binding]; other site 585395004244 substrate (anthranilate) binding pocket [chemical binding]; other site 585395004245 product (indole) binding pocket [chemical binding]; other site 585395004246 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 585395004247 active site 585395004248 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 585395004249 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 585395004250 glutamine binding [chemical binding]; other site 585395004251 catalytic triad [active] 585395004252 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585395004253 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 585395004254 anthranilate synthase component I; Provisional; Region: PRK13564 585395004255 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 585395004256 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 585395004257 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 585395004258 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 585395004259 active site 585395004260 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 585395004261 hypothetical protein; Provisional; Region: PRK11630 585395004262 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 585395004263 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585395004264 RNA binding surface [nucleotide binding]; other site 585395004265 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 585395004266 probable active site [active] 585395004267 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 585395004268 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 585395004269 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 585395004270 homodimer interface [polypeptide binding]; other site 585395004271 Walker A motif; other site 585395004272 ATP binding site [chemical binding]; other site 585395004273 hydroxycobalamin binding site [chemical binding]; other site 585395004274 Walker B motif; other site 585395004275 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 585395004276 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 585395004277 NADP binding site [chemical binding]; other site 585395004278 homodimer interface [polypeptide binding]; other site 585395004279 active site 585395004280 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 585395004281 putative inner membrane peptidase; Provisional; Region: PRK11778 585395004282 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 585395004283 tandem repeat interface [polypeptide binding]; other site 585395004284 oligomer interface [polypeptide binding]; other site 585395004285 active site residues [active] 585395004286 hypothetical protein; Provisional; Region: PRK11037 585395004287 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 585395004288 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 585395004289 active site 585395004290 interdomain interaction site; other site 585395004291 putative metal-binding site [ion binding]; other site 585395004292 nucleotide binding site [chemical binding]; other site 585395004293 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 585395004294 domain I; other site 585395004295 DNA binding groove [nucleotide binding] 585395004296 phosphate binding site [ion binding]; other site 585395004297 domain II; other site 585395004298 domain III; other site 585395004299 nucleotide binding site [chemical binding]; other site 585395004300 catalytic site [active] 585395004301 domain IV; other site 585395004302 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585395004303 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585395004304 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 585395004305 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 585395004306 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 585395004307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395004308 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 585395004309 substrate binding site [chemical binding]; other site 585395004310 putative dimerization interface [polypeptide binding]; other site 585395004311 conserved predicted protein, C-terminal fragment 585395004312 aconitate hydratase; Validated; Region: PRK09277 585395004313 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 585395004314 substrate binding site [chemical binding]; other site 585395004315 ligand binding site [chemical binding]; other site 585395004316 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 585395004317 substrate binding site [chemical binding]; other site 585395004318 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 585395004319 dimerization interface [polypeptide binding]; other site 585395004320 active site 585395004321 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585395004322 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 585395004323 active site 585395004324 Predicted membrane protein [Function unknown]; Region: COG3771 585395004325 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 585395004326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 585395004327 TPR motif; other site 585395004328 binding surface 585395004329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585395004330 binding surface 585395004331 TPR motif; other site 585395004332 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 585395004333 active site 585395004334 dimer interface [polypeptide binding]; other site 585395004335 translation initiation factor Sui1; Validated; Region: PRK06824 585395004336 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 585395004337 putative rRNA binding site [nucleotide binding]; other site 585395004338 lipoprotein; Provisional; Region: PRK10540 585395004339 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585395004340 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585395004341 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585395004342 hypothetical protein; Provisional; Region: PRK13658 585395004343 RNase II stability modulator; Provisional; Region: PRK10060 585395004344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585395004345 putative active site [active] 585395004346 heme pocket [chemical binding]; other site 585395004347 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395004348 metal binding site [ion binding]; metal-binding site 585395004349 active site 585395004350 I-site; other site 585395004351 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395004352 exoribonuclease II; Provisional; Region: PRK05054 585395004353 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 585395004354 RNB domain; Region: RNB; pfam00773 585395004355 S1 RNA binding domain; Region: S1; pfam00575 585395004356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 585395004357 Uncharacterized conserved protein [Function unknown]; Region: COG2128 585395004358 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 585395004359 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 585395004360 NAD binding site [chemical binding]; other site 585395004361 homotetramer interface [polypeptide binding]; other site 585395004362 homodimer interface [polypeptide binding]; other site 585395004363 substrate binding site [chemical binding]; other site 585395004364 active site 585395004365 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 585395004366 putative active site [active] 585395004367 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 585395004368 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395004369 Walker A/P-loop; other site 585395004370 ATP binding site [chemical binding]; other site 585395004371 Q-loop/lid; other site 585395004372 ABC transporter signature motif; other site 585395004373 Walker B; other site 585395004374 D-loop; other site 585395004375 H-loop/switch region; other site 585395004376 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 585395004377 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395004378 Walker A/P-loop; other site 585395004379 ATP binding site [chemical binding]; other site 585395004380 Q-loop/lid; other site 585395004381 ABC transporter signature motif; other site 585395004382 Walker B; other site 585395004383 D-loop; other site 585395004384 H-loop/switch region; other site 585395004385 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585395004386 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 585395004387 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585395004388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395004389 dimer interface [polypeptide binding]; other site 585395004390 conserved gate region; other site 585395004391 putative PBP binding loops; other site 585395004392 ABC-ATPase subunit interface; other site 585395004393 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 585395004394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395004395 dimer interface [polypeptide binding]; other site 585395004396 conserved gate region; other site 585395004397 putative PBP binding loops; other site 585395004398 ABC-ATPase subunit interface; other site 585395004399 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 585395004400 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 585395004401 peptide binding site [polypeptide binding]; other site 585395004402 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 585395004403 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 585395004404 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 585395004405 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 585395004406 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 585395004407 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 585395004408 catalytic triad [active] 585395004409 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 585395004410 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395004411 non-specific DNA binding site [nucleotide binding]; other site 585395004412 salt bridge; other site 585395004413 sequence-specific DNA binding site [nucleotide binding]; other site 585395004414 Cupin domain; Region: Cupin_2; pfam07883 585395004415 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 585395004416 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 585395004417 NAD(P) binding site [chemical binding]; other site 585395004418 catalytic residues [active] 585395004419 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 585395004420 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 585395004421 4-aminobutyrate transaminase; Provisional; Region: PRK09792 585395004422 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585395004423 inhibitor-cofactor binding pocket; inhibition site 585395004424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395004425 catalytic residue [active] 585395004426 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 585395004427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395004428 Walker A motif; other site 585395004429 ATP binding site [chemical binding]; other site 585395004430 Walker B motif; other site 585395004431 arginine finger; other site 585395004432 phage shock protein PspA; Provisional; Region: PRK10698 585395004433 phage shock protein B; Provisional; Region: pspB; PRK09458 585395004434 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 585395004435 phage shock protein C; Region: phageshock_pspC; TIGR02978 585395004436 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 585395004437 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585395004438 active site residue [active] 585395004439 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 585395004440 sucrose phosphorylase; Provisional; Region: PRK13840 585395004441 active site 585395004442 homodimer interface [polypeptide binding]; other site 585395004443 catalytic site [active] 585395004444 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 585395004445 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 585395004446 predicted sugar transporter subunit: membrane component of ABC superfamily, middle part truncated 585395004447 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 585395004448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395004449 dimer interface [polypeptide binding]; other site 585395004450 conserved gate region; other site 585395004451 putative PBP binding loops; other site 585395004452 ABC-ATPase subunit interface; other site 585395004453 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585395004454 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 585395004455 putative NAD(P) binding site [chemical binding]; other site 585395004456 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 585395004457 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585395004458 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585395004459 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585395004460 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 585395004461 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 585395004462 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 585395004463 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 585395004464 beta-phosphoglucomutase; Region: bPGM; TIGR01990 585395004465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395004466 motif II; other site 585395004467 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 585395004468 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585395004469 Walker A/P-loop; other site 585395004470 ATP binding site [chemical binding]; other site 585395004471 Q-loop/lid; other site 585395004472 ABC transporter signature motif; other site 585395004473 Walker B; other site 585395004474 D-loop; other site 585395004475 H-loop/switch region; other site 585395004476 TOBE domain; Region: TOBE_2; pfam08402 585395004477 outer membrane porin OmpG, N-terminal part 585395004478 outer membrane porin OmpG, C-terminal part 585395004479 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585395004480 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585395004481 DNA binding site [nucleotide binding] 585395004482 domain linker motif; other site 585395004483 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 585395004484 putative dimerization interface [polypeptide binding]; other site 585395004485 putative ligand binding site [chemical binding]; other site 585395004486 Predicted ATPase [General function prediction only]; Region: COG3106 585395004487 Predicted membrane protein [Function unknown]; Region: COG3768 585395004488 TIGR01620 family protein; Region: hyp_HI0043 585395004489 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 585395004490 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 585395004491 putative aromatic amino acid binding site; other site 585395004492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395004493 Walker A motif; other site 585395004494 ATP binding site [chemical binding]; other site 585395004495 Walker B motif; other site 585395004496 arginine finger; other site 585395004497 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 585395004498 dimer interface [polypeptide binding]; other site 585395004499 catalytic triad [active] 585395004500 peroxidatic and resolving cysteines [active] 585395004501 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 585395004502 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 585395004503 active site 585395004504 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 585395004505 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 585395004506 putative active site [active] 585395004507 Zn binding site [ion binding]; other site 585395004508 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 585395004509 NADH(P)-binding; Region: NAD_binding_10; pfam13460 585395004510 putative NAD(P) binding site [chemical binding]; other site 585395004511 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 585395004512 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 585395004513 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585395004514 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585395004515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395004516 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 585395004517 putative effector binding pocket; other site 585395004518 putative dimerization interface [polypeptide binding]; other site 585395004519 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 585395004520 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 585395004521 peptide binding site [polypeptide binding]; other site 585395004522 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 585395004523 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585395004524 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 585395004525 universal stress protein UspE; Provisional; Region: PRK11175 585395004526 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585395004527 Ligand Binding Site [chemical binding]; other site 585395004528 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585395004529 Ligand Binding Site [chemical binding]; other site 585395004530 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 585395004531 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585395004532 ligand binding site [chemical binding]; other site 585395004533 flexible hinge region; other site 585395004534 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 585395004535 putative switch regulator; other site 585395004536 non-specific DNA interactions [nucleotide binding]; other site 585395004537 DNA binding site [nucleotide binding] 585395004538 sequence specific DNA binding site [nucleotide binding]; other site 585395004539 putative cAMP binding site [chemical binding]; other site 585395004540 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 585395004541 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 585395004542 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585395004543 DNA binding site [nucleotide binding] 585395004544 active site 585395004545 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 585395004546 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 585395004547 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 585395004548 amidohydrolase; Region: amidohydrolases; TIGR01891 585395004549 putative metal binding site [ion binding]; other site 585395004550 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 585395004551 amidohydrolase; Region: amidohydrolases; TIGR01891 585395004552 putative metal binding site [ion binding]; other site 585395004553 dimer interface [polypeptide binding]; other site 585395004554 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 585395004555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395004556 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 585395004557 putative substrate binding pocket [chemical binding]; other site 585395004558 putative dimerization interface [polypeptide binding]; other site 585395004559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 585395004560 Smr domain; Region: Smr; pfam01713 585395004561 PAS domain S-box; Region: sensory_box; TIGR00229 585395004562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585395004563 putative active site [active] 585395004564 heme pocket [chemical binding]; other site 585395004565 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585395004566 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395004567 metal binding site [ion binding]; metal-binding site 585395004568 active site 585395004569 I-site; other site 585395004570 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 585395004571 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 585395004572 Cl binding site [ion binding]; other site 585395004573 oligomer interface [polypeptide binding]; other site 585395004574 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 585395004575 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585395004576 ATP binding site [chemical binding]; other site 585395004577 Mg++ binding site [ion binding]; other site 585395004578 motif III; other site 585395004579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395004580 nucleotide binding region [chemical binding]; other site 585395004581 ATP-binding site [chemical binding]; other site 585395004582 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 585395004583 putative RNA binding site [nucleotide binding]; other site 585395004584 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 585395004585 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 585395004586 Ligand Binding Site [chemical binding]; other site 585395004587 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585395004588 Ligand Binding Site [chemical binding]; other site 585395004589 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585395004590 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585395004591 trimer interface [polypeptide binding]; other site 585395004592 eyelet of channel; other site 585395004593 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 585395004594 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 585395004595 dimer interface [polypeptide binding]; other site 585395004596 PYR/PP interface [polypeptide binding]; other site 585395004597 TPP binding site [chemical binding]; other site 585395004598 substrate binding site [chemical binding]; other site 585395004599 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 585395004600 Domain of unknown function; Region: EKR; smart00890 585395004601 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585395004602 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585395004603 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 585395004604 TPP-binding site [chemical binding]; other site 585395004605 dimer interface [polypeptide binding]; other site 585395004606 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 585395004607 Domain of unknown function (DUF333); Region: DUF333; pfam03891 585395004608 heat-inducible protein; Provisional; Region: PRK10449 585395004609 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 585395004610 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 585395004611 putative ligand binding site [chemical binding]; other site 585395004612 putative NAD binding site [chemical binding]; other site 585395004613 catalytic site [active] 585395004614 conserved predicted protein, N-terminal part 585395004615 conserved predicted protein, C-terminal part 585395004616 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 585395004617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 585395004618 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 585395004619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395004620 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 585395004621 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 585395004622 NAD(P) binding site [chemical binding]; other site 585395004623 catalytic residues [active] 585395004624 tyramine oxidase; Provisional; Region: tynA; PRK14696 585395004625 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 585395004626 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 585395004627 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 585395004628 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 585395004629 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 585395004630 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 585395004631 substrate binding site [chemical binding]; other site 585395004632 dimer interface [polypeptide binding]; other site 585395004633 NADP binding site [chemical binding]; other site 585395004634 catalytic residues [active] 585395004635 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 585395004636 substrate binding site [chemical binding]; other site 585395004637 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 585395004638 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 585395004639 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 585395004640 phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158 585395004641 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 585395004642 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 585395004643 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 585395004644 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 585395004645 FAD binding pocket [chemical binding]; other site 585395004646 FAD binding motif [chemical binding]; other site 585395004647 phosphate binding motif [ion binding]; other site 585395004648 beta-alpha-beta structure motif; other site 585395004649 NAD(p) ribose binding residues [chemical binding]; other site 585395004650 NAD binding pocket [chemical binding]; other site 585395004651 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 585395004652 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585395004653 catalytic loop [active] 585395004654 iron binding site [ion binding]; other site 585395004655 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 585395004656 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585395004657 substrate binding site [chemical binding]; other site 585395004658 oxyanion hole (OAH) forming residues; other site 585395004659 trimer interface [polypeptide binding]; other site 585395004660 enoyl-CoA hydratase; Provisional; Region: PRK08140 585395004661 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585395004662 substrate binding site [chemical binding]; other site 585395004663 oxyanion hole (OAH) forming residues; other site 585395004664 trimer interface [polypeptide binding]; other site 585395004665 3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279 585395004666 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585395004667 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585395004668 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585395004669 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585395004670 CoenzymeA binding site [chemical binding]; other site 585395004671 subunit interaction site [polypeptide binding]; other site 585395004672 PHB binding site; other site 585395004673 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 585395004674 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585395004675 dimer interface [polypeptide binding]; other site 585395004676 active site 585395004677 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 585395004678 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 585395004679 active site 585395004680 AMP binding site [chemical binding]; other site 585395004681 homodimer interface [polypeptide binding]; other site 585395004682 acyl-activating enzyme (AAE) consensus motif; other site 585395004683 CoA binding site [chemical binding]; other site 585395004684 PaaX-like protein; Region: PaaX; pfam07848 585395004685 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 585395004686 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 585395004687 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 585395004688 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 585395004689 putative trimer interface [polypeptide binding]; other site 585395004690 putative metal binding site [ion binding]; other site 585395004691 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585395004692 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585395004693 active site 585395004694 catalytic tetrad [active] 585395004695 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 585395004696 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 585395004697 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 585395004698 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 585395004699 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 585395004700 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 585395004701 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585395004702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395004703 S-adenosylmethionine binding site [chemical binding]; other site 585395004704 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 585395004705 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585395004706 active site 585395004707 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 585395004708 active site 585395004709 catalytic residues [active] 585395004710 azoreductase; Reviewed; Region: PRK00170 585395004711 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585395004712 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 585395004713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395004714 ATP binding site [chemical binding]; other site 585395004715 putative Mg++ binding site [ion binding]; other site 585395004716 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395004717 nucleotide binding region [chemical binding]; other site 585395004718 ATP-binding site [chemical binding]; other site 585395004719 Helicase associated domain (HA2); Region: HA2; pfam04408 585395004720 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 585395004721 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 585395004722 Uncharacterized conserved protein [Function unknown]; Region: COG1434 585395004723 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585395004724 putative active site [active] 585395004725 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 585395004726 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 585395004727 NAD binding site [chemical binding]; other site 585395004728 catalytic residues [active] 585395004729 substrate binding site [chemical binding]; other site 585395004730 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 585395004731 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585395004732 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585395004733 cytochrome b561; Provisional; Region: PRK11513 585395004734 hypothetical protein; Provisional; Region: PRK10040 585395004735 small toxic polypeptide; Provisional; Region: PRK09738 585395004736 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 585395004737 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585395004738 dimer interface [polypeptide binding]; other site 585395004739 ligand binding site [chemical binding]; other site 585395004740 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585395004741 dimerization interface [polypeptide binding]; other site 585395004742 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585395004743 dimer interface [polypeptide binding]; other site 585395004744 putative CheW interface [polypeptide binding]; other site 585395004745 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 585395004746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395004747 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585395004748 dimerization interface [polypeptide binding]; other site 585395004749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 585395004750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 585395004751 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 585395004752 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 585395004753 hypothetical protein; Provisional; Region: PRK11415 585395004754 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 585395004755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395004756 Coenzyme A binding pocket [chemical binding]; other site 585395004757 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 585395004758 putative trimer interface [polypeptide binding]; other site 585395004759 putative CoA binding site [chemical binding]; other site 585395004760 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 585395004761 putative trimer interface [polypeptide binding]; other site 585395004762 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 585395004763 putative CoA binding site [chemical binding]; other site 585395004764 putative trimer interface [polypeptide binding]; other site 585395004765 putative CoA binding site [chemical binding]; other site 585395004766 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 585395004767 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 585395004768 gating phenylalanine in ion channel; other site 585395004769 tellurite resistance protein TehB; Provisional; Region: PRK11207 585395004770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395004771 S-adenosylmethionine binding site [chemical binding]; other site 585395004772 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 585395004773 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 585395004774 Probable transposase; Region: OrfB_IS605; pfam01385 585395004775 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 585395004776 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 585395004777 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 585395004778 benzoate transporter; Region: benE; TIGR00843 585395004779 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585395004780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395004781 non-specific DNA binding site [nucleotide binding]; other site 585395004782 salt bridge; other site 585395004783 sequence-specific DNA binding site [nucleotide binding]; other site 585395004784 Cupin domain; Region: Cupin_2; pfam07883 585395004785 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585395004786 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585395004787 Peptidase family U32; Region: Peptidase_U32; pfam01136 585395004788 Collagenase; Region: DUF3656; pfam12392 585395004789 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 585395004790 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 585395004791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395004792 sequence-specific DNA binding site [nucleotide binding]; other site 585395004793 salt bridge; other site 585395004794 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585395004795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395004796 DNA-binding site [nucleotide binding]; DNA binding site 585395004797 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585395004798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395004799 homodimer interface [polypeptide binding]; other site 585395004800 catalytic residue [active] 585395004801 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 585395004802 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 585395004803 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 585395004804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395004805 Walker A/P-loop; other site 585395004806 ATP binding site [chemical binding]; other site 585395004807 Q-loop/lid; other site 585395004808 ABC transporter signature motif; other site 585395004809 Walker B; other site 585395004810 D-loop; other site 585395004811 H-loop/switch region; other site 585395004812 TOBE domain; Region: TOBE_2; pfam08402 585395004813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395004814 dimer interface [polypeptide binding]; other site 585395004815 conserved gate region; other site 585395004816 putative PBP binding loops; other site 585395004817 ABC-ATPase subunit interface; other site 585395004818 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585395004819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395004820 ABC-ATPase subunit interface; other site 585395004821 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 585395004822 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 585395004823 tetrameric interface [polypeptide binding]; other site 585395004824 NAD binding site [chemical binding]; other site 585395004825 catalytic residues [active] 585395004826 substrate binding site [chemical binding]; other site 585395004827 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 585395004828 trimer interface [polypeptide binding]; other site 585395004829 active site 585395004830 substrate binding site [chemical binding]; other site 585395004831 CoA binding site [chemical binding]; other site 585395004832 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 585395004833 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 585395004834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 585395004835 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 585395004836 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 585395004837 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 585395004838 Prostaglandin dehydrogenases; Region: PGDH; cd05288 585395004839 NAD(P) binding site [chemical binding]; other site 585395004840 substrate binding site [chemical binding]; other site 585395004841 dimer interface [polypeptide binding]; other site 585395004842 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 585395004843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395004844 DNA-binding site [nucleotide binding]; DNA binding site 585395004845 FCD domain; Region: FCD; pfam07729 585395004846 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 585395004847 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585395004848 N-terminal plug; other site 585395004849 ligand-binding site [chemical binding]; other site 585395004850 PQQ-like domain; Region: PQQ_2; pfam13360 585395004851 L-asparagine permease; Provisional; Region: PRK15049 585395004852 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 585395004853 C-terminal domain interface [polypeptide binding]; other site 585395004854 GSH binding site (G-site) [chemical binding]; other site 585395004855 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 585395004856 dimer interface [polypeptide binding]; other site 585395004857 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 585395004858 dimer interface [polypeptide binding]; other site 585395004859 N-terminal domain interface [polypeptide binding]; other site 585395004860 substrate binding pocket (H-site) [chemical binding]; other site 585395004861 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 585395004862 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585395004863 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585395004864 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585395004865 PAAR motif; Region: PAAR_motif; cl15808 585395004866 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585395004867 RHS Repeat; Region: RHS_repeat; pfam05593 585395004868 RHS Repeat; Region: RHS_repeat; pfam05593 585395004869 RHS Repeat; Region: RHS_repeat; pfam05593 585395004870 RHS Repeat; Region: RHS_repeat; pfam05593 585395004871 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585395004872 RHS Repeat; Region: RHS_repeat; pfam05593 585395004873 RHS Repeat; Region: RHS_repeat; pfam05593 585395004874 RHS protein; Region: RHS; pfam03527 585395004875 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585395004876 RhsE, IS677, H repeat-associated protein 585395004877 RhsE, IS677, H repeat-associated protein, C-terminal fragment 585395004878 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 585395004879 active site 1 [active] 585395004880 dimer interface [polypeptide binding]; other site 585395004881 hexamer interface [polypeptide binding]; other site 585395004882 active site 2 [active] 585395004883 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 585395004884 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 585395004885 hypothetical protein; Provisional; Region: PRK10281 585395004886 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 585395004887 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 585395004888 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 585395004889 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 585395004890 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 585395004891 [4Fe-4S] binding site [ion binding]; other site 585395004892 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585395004893 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585395004894 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585395004895 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 585395004896 molybdopterin cofactor binding site; other site 585395004897 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 585395004898 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 585395004899 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 585395004900 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585395004901 aromatic amino acid exporter; Provisional; Region: PRK11689 585395004902 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 585395004903 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585395004904 [4Fe-4S] binding site [ion binding]; other site 585395004905 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585395004906 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585395004907 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 585395004908 molybdopterin cofactor binding site; other site 585395004909 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 585395004910 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 585395004911 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 585395004912 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 585395004913 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 585395004914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395004915 non-specific DNA binding site [nucleotide binding]; other site 585395004916 salt bridge; other site 585395004917 sequence-specific DNA binding site [nucleotide binding]; other site 585395004918 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 585395004919 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 585395004920 NAD binding site [chemical binding]; other site 585395004921 substrate binding site [chemical binding]; other site 585395004922 catalytic Zn binding site [ion binding]; other site 585395004923 tetramer interface [polypeptide binding]; other site 585395004924 structural Zn binding site [ion binding]; other site 585395004925 malate dehydrogenase; Provisional; Region: PRK13529 585395004926 Malic enzyme, N-terminal domain; Region: malic; pfam00390 585395004927 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 585395004928 NAD(P) binding site [chemical binding]; other site 585395004929 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 585395004930 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 585395004931 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 585395004932 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 585395004933 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395004934 Walker A/P-loop; other site 585395004935 ATP binding site [chemical binding]; other site 585395004936 Q-loop/lid; other site 585395004937 ABC transporter signature motif; other site 585395004938 Walker B; other site 585395004939 D-loop; other site 585395004940 H-loop/switch region; other site 585395004941 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 585395004942 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 585395004943 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395004944 Walker A/P-loop; other site 585395004945 ATP binding site [chemical binding]; other site 585395004946 Q-loop/lid; other site 585395004947 ABC transporter signature motif; other site 585395004948 Walker B; other site 585395004949 D-loop; other site 585395004950 H-loop/switch region; other site 585395004951 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 585395004952 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 585395004953 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585395004954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395004955 dimer interface [polypeptide binding]; other site 585395004956 conserved gate region; other site 585395004957 putative PBP binding loops; other site 585395004958 ABC-ATPase subunit interface; other site 585395004959 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 585395004960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395004961 dimer interface [polypeptide binding]; other site 585395004962 conserved gate region; other site 585395004963 putative PBP binding loops; other site 585395004964 ABC-ATPase subunit interface; other site 585395004965 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 585395004966 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 585395004967 D-ala-D-ala dipeptidase, Zn-dependent, C-terminal fragment 585395004968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 585395004969 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 585395004970 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 585395004971 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 585395004972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395004973 catalytic residue [active] 585395004974 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585395004975 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 585395004976 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585395004977 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585395004978 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585395004979 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 585395004980 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 585395004981 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 585395004982 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 585395004983 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 585395004984 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 585395004985 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395004986 FeS/SAM binding site; other site 585395004987 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 585395004988 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 585395004989 Sulfatase; Region: Sulfatase; pfam00884 585395004990 transcriptional regulator YdeO; Provisional; Region: PRK09940 585395004991 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395004992 putative oxidoreductase; Provisional; Region: PRK09939 585395004993 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 585395004994 putative molybdopterin cofactor binding site [chemical binding]; other site 585395004995 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 585395004996 putative molybdopterin cofactor binding site; other site 585395004997 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 585395004998 mannosyl binding site [chemical binding]; other site 585395004999 Fimbrial protein; Region: Fimbrial; pfam00419 585395005000 predicted fimbrial-like adhesin protein, C-terminal part 585395005001 Transposase; Region: HTH_Tnp_1; cl17663 585395005002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395005003 putative transposase OrfB; Reviewed; Region: PHA02517 585395005004 HTH-like domain; Region: HTH_21; pfam13276 585395005005 Integrase core domain; Region: rve; pfam00665 585395005006 Integrase core domain; Region: rve_3; pfam13683 585395005007 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585395005008 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585395005009 PapC N-terminal domain; Region: PapC_N; pfam13954 585395005010 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585395005011 PapC C-terminal domain; Region: PapC_C; pfam13953 585395005012 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 585395005013 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585395005014 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585395005015 type 1 fimbrial protein precursor, N-terminal part 585395005016 Helix-turn-helix domain; Region: HTH_18; pfam12833 585395005017 HipA N-terminal domain; Region: Couple_hipA; pfam13657 585395005018 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 585395005019 HipA-like N-terminal domain; Region: HipA_N; pfam07805 585395005020 HipA-like C-terminal domain; Region: HipA_C; pfam07804 585395005021 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585395005022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395005023 non-specific DNA binding site [nucleotide binding]; other site 585395005024 salt bridge; other site 585395005025 sequence-specific DNA binding site [nucleotide binding]; other site 585395005026 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 585395005027 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585395005028 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585395005029 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585395005030 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 585395005031 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 585395005032 putative N- and C-terminal domain interface [polypeptide binding]; other site 585395005033 putative active site [active] 585395005034 putative MgATP binding site [chemical binding]; other site 585395005035 catalytic site [active] 585395005036 metal binding site [ion binding]; metal-binding site 585395005037 putative carbohydrate binding site [chemical binding]; other site 585395005038 transcriptional regulator LsrR; Provisional; Region: PRK15418 585395005039 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 585395005040 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 585395005041 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 585395005042 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585395005043 Walker A/P-loop; other site 585395005044 ATP binding site [chemical binding]; other site 585395005045 Q-loop/lid; other site 585395005046 ABC transporter signature motif; other site 585395005047 Walker B; other site 585395005048 D-loop; other site 585395005049 H-loop/switch region; other site 585395005050 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585395005051 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585395005052 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585395005053 TM-ABC transporter signature motif; other site 585395005054 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585395005055 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585395005056 TM-ABC transporter signature motif; other site 585395005057 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 585395005058 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 585395005059 ligand binding site [chemical binding]; other site 585395005060 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 585395005061 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 585395005062 putative active site; other site 585395005063 catalytic residue [active] 585395005064 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 585395005065 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 585395005066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395005067 S-adenosylmethionine binding site [chemical binding]; other site 585395005068 Predicted membrane protein [Function unknown]; Region: COG3781 585395005069 altronate oxidoreductase; Provisional; Region: PRK03643 585395005070 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585395005071 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585395005072 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585395005073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395005074 metal binding site [ion binding]; metal-binding site 585395005075 active site 585395005076 I-site; other site 585395005077 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 585395005078 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 585395005079 glutaminase; Provisional; Region: PRK00971 585395005080 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 585395005081 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 585395005082 NAD(P) binding site [chemical binding]; other site 585395005083 catalytic residues [active] 585395005084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585395005085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395005086 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 585395005087 putative dimerization interface [polypeptide binding]; other site 585395005088 conserved predicted protein, N-terminal fragment 585395005089 conserved predicted protein, C-terminal part 585395005090 putative arabinose transporter; Provisional; Region: PRK03545 585395005091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395005092 putative substrate translocation pore; other site 585395005093 inner membrane protein; Provisional; Region: PRK10995 585395005094 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 585395005095 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585395005096 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 585395005097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395005098 hypothetical protein; Provisional; Region: PRK10106 585395005099 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 585395005100 beta-galactosidase; Region: BGL; TIGR03356 585395005101 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 585395005102 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585395005103 trimer interface; other site 585395005104 sugar binding site [chemical binding]; other site 585395005105 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 585395005106 active site 585395005107 methionine cluster; other site 585395005108 phosphorylation site [posttranslational modification] 585395005109 metal binding site [ion binding]; metal-binding site 585395005110 PTS system component IIC protein, C-terminal part 585395005111 PTS system component IIC protein, N-terminal part 585395005112 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 585395005113 active site 585395005114 P-loop; other site 585395005115 phosphorylation site [posttranslational modification] 585395005116 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585395005117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395005118 DNA-binding site [nucleotide binding]; DNA binding site 585395005119 UTRA domain; Region: UTRA; pfam07702 585395005120 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 585395005121 EamA-like transporter family; Region: EamA; pfam00892 585395005122 EamA-like transporter family; Region: EamA; pfam00892 585395005123 putative transporter; Provisional; Region: PRK10054 585395005124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395005125 putative substrate translocation pore; other site 585395005126 diguanylate cyclase; Provisional; Region: PRK09894 585395005127 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 585395005128 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395005129 metal binding site [ion binding]; metal-binding site 585395005130 active site 585395005131 I-site; other site 585395005132 hypothetical protein; Provisional; Region: PRK10053 585395005133 hypothetical protein; Validated; Region: PRK03657 585395005134 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 585395005135 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 585395005136 active site 585395005137 Zn binding site [ion binding]; other site 585395005138 malonic semialdehyde reductase; Provisional; Region: PRK10538 585395005139 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 585395005140 putative NAD(P) binding site [chemical binding]; other site 585395005141 homodimer interface [polypeptide binding]; other site 585395005142 homotetramer interface [polypeptide binding]; other site 585395005143 active site 585395005144 Transcriptional regulators [Transcription]; Region: GntR; COG1802 585395005145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395005146 DNA-binding site [nucleotide binding]; DNA binding site 585395005147 FCD domain; Region: FCD; pfam07729 585395005148 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 585395005149 predicted mannonate dehydrogenase, C-terminal part 585395005150 predicted mannonate dehydrogenase, N-terminal fragment 585395005151 metabolite-proton symporter; Region: 2A0106; TIGR00883 585395005152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395005153 putative substrate translocation pore; other site 585395005154 Prophage ECO103_P06, lambda-like phage 585395005155 DinI-like family; Region: DinI; pfam06183 585395005156 Prophage ECO103_P06; T3SS effector NleG-like protein, N-terminal part 585395005157 putative transposase OrfB; Reviewed; Region: PHA02517 585395005158 HTH-like domain; Region: HTH_21; pfam13276 585395005159 Integrase core domain; Region: rve; pfam00665 585395005160 Integrase core domain; Region: rve_3; pfam13683 585395005161 Transposase; Region: HTH_Tnp_1; cl17663 585395005162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395005163 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 585395005164 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 585395005165 Lysis protein S; Region: Lysis_S; pfam04971 585395005166 Protein of unknown function (DUF826); Region: DUF826; pfam05696 585395005167 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585395005168 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585395005169 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 585395005170 Prophage ECO103_P06; predicted TciA/TerB-like protein, C-terminal part 585395005171 Antitermination protein; Region: Antiterm; pfam03589 585395005172 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585395005173 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585395005174 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585395005175 adenylosuccinate lyase; Provisional; Region: PRK09285 585395005176 Hok/gef family; Region: HOK_GEF; pfam01848 585395005177 Hok/gef family; Region: HOK_GEF; pfam01848 585395005178 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 585395005179 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 585395005180 Prophage ECO103_P06; fimbrial minor pilin protein precursor, partial 585395005181 Prophage ECO103_P06; fimbrial minor pilin protein precursor, partial 585395005182 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 585395005183 Pyocin large subunit [General function prediction only]; Region: COG5529 585395005184 Helix-turn-helix domain; Region: HTH_36; pfam13730 585395005185 primosomal protein DnaI; Provisional; Region: PRK02854 585395005186 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585395005187 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 585395005188 transcriptional repressor DicA; Reviewed; Region: PRK09706 585395005189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395005190 sequence-specific DNA binding site [nucleotide binding]; other site 585395005191 salt bridge; other site 585395005192 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 585395005193 DicB protein; Region: DicB; pfam05358 585395005194 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585395005195 exonuclease VIII; Reviewed; Region: PRK09709 585395005196 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 585395005197 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 585395005198 active site 585395005199 substrate binding site [chemical binding]; other site 585395005200 catalytic site [active] 585395005201 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 585395005202 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 585395005203 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585395005204 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 585395005205 Int/Topo IB signature motif; other site 585395005206 putative oxidoreductase; Provisional; Region: PRK10083 585395005207 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 585395005208 putative NAD(P) binding site [chemical binding]; other site 585395005209 catalytic Zn binding site [ion binding]; other site 585395005210 structural Zn binding site [ion binding]; other site 585395005211 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 585395005212 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 585395005213 putative active site pocket [active] 585395005214 putative metal binding site [ion binding]; other site 585395005215 hypothetical protein; Provisional; Region: PRK02237 585395005216 hypothetical protein; Provisional; Region: PRK13659 585395005217 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 585395005218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395005219 Coenzyme A binding pocket [chemical binding]; other site 585395005220 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 585395005221 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 585395005222 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 585395005223 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 585395005224 putative [Fe4-S4] binding site [ion binding]; other site 585395005225 putative molybdopterin cofactor binding site [chemical binding]; other site 585395005226 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 585395005227 putative molybdopterin cofactor binding site; other site 585395005228 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 585395005229 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 585395005230 putative [Fe4-S4] binding site [ion binding]; other site 585395005231 putative molybdopterin cofactor binding site [chemical binding]; other site 585395005232 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 585395005233 putative molybdopterin cofactor binding site; other site 585395005234 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 585395005235 4Fe-4S binding domain; Region: Fer4; cl02805 585395005236 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 585395005237 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 585395005238 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585395005239 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 585395005240 Cl- selectivity filter; other site 585395005241 Cl- binding residues [ion binding]; other site 585395005242 pore gating glutamate residue; other site 585395005243 dimer interface [polypeptide binding]; other site 585395005244 putative dithiobiotin synthetase; Provisional; Region: PRK12374 585395005245 AAA domain; Region: AAA_26; pfam13500 585395005246 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 585395005247 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585395005248 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585395005249 nucleotide binding site [chemical binding]; other site 585395005250 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 585395005251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395005252 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 585395005253 dimerization interface [polypeptide binding]; other site 585395005254 substrate binding pocket [chemical binding]; other site 585395005255 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 585395005256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395005257 putative substrate translocation pore; other site 585395005258 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 585395005259 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 585395005260 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 585395005261 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 585395005262 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585395005263 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 585395005264 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 585395005265 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 585395005266 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 585395005267 ligand binding site [chemical binding]; other site 585395005268 homodimer interface [polypeptide binding]; other site 585395005269 NAD(P) binding site [chemical binding]; other site 585395005270 trimer interface B [polypeptide binding]; other site 585395005271 trimer interface A [polypeptide binding]; other site 585395005272 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 585395005273 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585395005274 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585395005275 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585395005276 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 585395005277 Spore germination protein; Region: Spore_permease; cl17796 585395005278 dihydromonapterin reductase; Provisional; Region: PRK06483 585395005279 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 585395005280 NADP binding site [chemical binding]; other site 585395005281 substrate binding pocket [chemical binding]; other site 585395005282 active site 585395005283 GlpM protein; Region: GlpM; pfam06942 585395005284 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 585395005285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395005286 active site 585395005287 phosphorylation site [posttranslational modification] 585395005288 intermolecular recognition site; other site 585395005289 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395005290 DNA binding site [nucleotide binding] 585395005291 sensor protein RstB; Provisional; Region: PRK10604 585395005292 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585395005293 dimerization interface [polypeptide binding]; other site 585395005294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395005295 dimer interface [polypeptide binding]; other site 585395005296 phosphorylation site [posttranslational modification] 585395005297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395005298 ATP binding site [chemical binding]; other site 585395005299 Mg2+ binding site [ion binding]; other site 585395005300 G-X-G motif; other site 585395005301 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 585395005302 fumarate hydratase; Reviewed; Region: fumC; PRK00485 585395005303 Class II fumarases; Region: Fumarase_classII; cd01362 585395005304 active site 585395005305 tetramer interface [polypeptide binding]; other site 585395005306 fumarate hydratase; Provisional; Region: PRK15389 585395005307 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 585395005308 Fumarase C-terminus; Region: Fumerase_C; pfam05683 585395005309 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 585395005310 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 585395005311 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 585395005312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 585395005313 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 585395005314 putative outer membrane porin protein; Provisional; Region: PRK11379 585395005315 glucuronide transporter; Provisional; Region: PRK09848 585395005316 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 585395005317 beta-D-glucuronidase; Provisional; Region: PRK10150 585395005318 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 585395005319 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 585395005320 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 585395005321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585395005322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585395005323 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 585395005324 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 585395005325 NAD binding site [chemical binding]; other site 585395005326 substrate binding site [chemical binding]; other site 585395005327 homotetramer interface [polypeptide binding]; other site 585395005328 homodimer interface [polypeptide binding]; other site 585395005329 active site 585395005330 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 585395005331 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585395005332 DNA binding site [nucleotide binding] 585395005333 domain linker motif; other site 585395005334 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 585395005335 putative dimerization interface [polypeptide binding]; other site 585395005336 putative ligand binding site [chemical binding]; other site 585395005337 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 585395005338 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 585395005339 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585395005340 active site turn [active] 585395005341 phosphorylation site [posttranslational modification] 585395005342 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 585395005343 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585395005344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395005345 homodimer interface [polypeptide binding]; other site 585395005346 catalytic residue [active] 585395005347 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 585395005348 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 585395005349 active site 585395005350 purine riboside binding site [chemical binding]; other site 585395005351 putative oxidoreductase; Provisional; Region: PRK11579 585395005352 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585395005353 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585395005354 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 585395005355 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 585395005356 electron transport complex protein RsxA; Provisional; Region: PRK05151 585395005357 electron transport complex protein RnfB; Provisional; Region: PRK05113 585395005358 Putative Fe-S cluster; Region: FeS; pfam04060 585395005359 4Fe-4S binding domain; Region: Fer4; pfam00037 585395005360 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 585395005361 SLBB domain; Region: SLBB; pfam10531 585395005362 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585395005363 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 585395005364 electron transport complex protein RnfG; Validated; Region: PRK01908 585395005365 electron transport complex RsxE subunit; Provisional; Region: PRK12405 585395005366 endonuclease III; Provisional; Region: PRK10702 585395005367 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585395005368 minor groove reading motif; other site 585395005369 helix-hairpin-helix signature motif; other site 585395005370 substrate binding pocket [chemical binding]; other site 585395005371 active site 585395005372 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 585395005373 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 585395005374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395005375 putative substrate translocation pore; other site 585395005376 POT family; Region: PTR2; pfam00854 585395005377 glutathionine S-transferase; Provisional; Region: PRK10542 585395005378 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 585395005379 C-terminal domain interface [polypeptide binding]; other site 585395005380 GSH binding site (G-site) [chemical binding]; other site 585395005381 dimer interface [polypeptide binding]; other site 585395005382 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 585395005383 N-terminal domain interface [polypeptide binding]; other site 585395005384 dimer interface [polypeptide binding]; other site 585395005385 substrate binding pocket (H-site) [chemical binding]; other site 585395005386 pyridoxamine kinase; Validated; Region: PRK05756 585395005387 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 585395005388 dimer interface [polypeptide binding]; other site 585395005389 pyridoxal binding site [chemical binding]; other site 585395005390 ATP binding site [chemical binding]; other site 585395005391 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 585395005392 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 585395005393 active site 585395005394 HIGH motif; other site 585395005395 dimer interface [polypeptide binding]; other site 585395005396 KMSKS motif; other site 585395005397 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585395005398 RNA binding surface [nucleotide binding]; other site 585395005399 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 585395005400 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 585395005401 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 585395005402 lysozyme inhibitor; Provisional; Region: PRK11372 585395005403 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 585395005404 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 585395005405 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 585395005406 transcriptional regulator SlyA; Provisional; Region: PRK03573 585395005407 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 585395005408 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 585395005409 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585395005410 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395005411 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395005412 Fusaric acid resistance protein family; Region: FUSC; pfam04632 585395005413 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585395005414 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 585395005415 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 585395005416 E-class dimer interface [polypeptide binding]; other site 585395005417 P-class dimer interface [polypeptide binding]; other site 585395005418 active site 585395005419 Cu2+ binding site [ion binding]; other site 585395005420 Zn2+ binding site [ion binding]; other site 585395005421 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585395005422 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585395005423 active site 585395005424 catalytic tetrad [active] 585395005425 Predicted Fe-S protein [General function prediction only]; Region: COG3313 585395005426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585395005427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585395005428 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 585395005429 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 585395005430 FMN binding site [chemical binding]; other site 585395005431 active site 585395005432 substrate binding site [chemical binding]; other site 585395005433 catalytic residue [active] 585395005434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585395005435 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 585395005436 dimer interface [polypeptide binding]; other site 585395005437 active site 585395005438 metal binding site [ion binding]; metal-binding site 585395005439 glutathione binding site [chemical binding]; other site 585395005440 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 585395005441 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 585395005442 dimer interface [polypeptide binding]; other site 585395005443 catalytic site [active] 585395005444 putative active site [active] 585395005445 putative substrate binding site [chemical binding]; other site 585395005446 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395005447 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 585395005448 ATP binding site [chemical binding]; other site 585395005449 putative Mg++ binding site [ion binding]; other site 585395005450 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395005451 nucleotide binding region [chemical binding]; other site 585395005452 ATP-binding site [chemical binding]; other site 585395005453 DEAD/H associated; Region: DEAD_assoc; pfam08494 585395005454 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 585395005455 putative GSH binding site [chemical binding]; other site 585395005456 catalytic residues [active] 585395005457 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585395005458 NlpC/P60 family; Region: NLPC_P60; pfam00877 585395005459 superoxide dismutase; Provisional; Region: PRK10543 585395005460 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 585395005461 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 585395005462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395005463 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585395005464 putative substrate translocation pore; other site 585395005465 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 585395005466 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585395005467 DNA binding site [nucleotide binding] 585395005468 domain linker motif; other site 585395005469 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 585395005470 dimerization interface [polypeptide binding]; other site 585395005471 ligand binding site [chemical binding]; other site 585395005472 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585395005473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395005474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585395005475 dimerization interface [polypeptide binding]; other site 585395005476 putative transporter; Provisional; Region: PRK11043 585395005477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395005478 putative substrate translocation pore; other site 585395005479 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 585395005480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 585395005481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395005482 S-adenosylmethionine binding site [chemical binding]; other site 585395005483 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 585395005484 Lumazine binding domain; Region: Lum_binding; pfam00677 585395005485 Lumazine binding domain; Region: Lum_binding; pfam00677 585395005486 multidrug efflux protein; Reviewed; Region: PRK01766 585395005487 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 585395005488 cation binding site [ion binding]; other site 585395005489 hypothetical protein; Provisional; Region: PRK09945 585395005490 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 585395005491 putative monooxygenase; Provisional; Region: PRK11118 585395005492 hypothetical protein; Provisional; Region: PRK09897 585395005493 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 585395005494 hypothetical protein; Provisional; Region: PRK09946 585395005495 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 585395005496 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 585395005497 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 585395005498 hypothetical protein; Provisional; Region: PRK09947 585395005499 predicted oxidoreductase, C-terminal part 585395005500 Transposase; Region: HTH_Tnp_1; cl17663 585395005501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395005502 putative transposase OrfB; Reviewed; Region: PHA02517 585395005503 HTH-like domain; Region: HTH_21; pfam13276 585395005504 Integrase core domain; Region: rve; pfam00665 585395005505 Integrase core domain; Region: rve_3; pfam13683 585395005506 predicted oxidoreductase, N-terminal part 585395005507 hypothetical protein; Provisional; Region: PRK09898 585395005508 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585395005509 hypothetical protein; Provisional; Region: PRK10292 585395005510 pyruvate kinase; Provisional; Region: PRK09206 585395005511 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 585395005512 domain interfaces; other site 585395005513 active site 585395005514 murein lipoprotein; Provisional; Region: PRK15396 585395005515 L,D-transpeptidase; Provisional; Region: PRK10190 585395005516 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585395005517 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585395005518 cysteine desufuration protein SufE; Provisional; Region: PRK09296 585395005519 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 585395005520 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 585395005521 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585395005522 catalytic residue [active] 585395005523 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 585395005524 FeS assembly protein SufD; Region: sufD; TIGR01981 585395005525 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 585395005526 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 585395005527 Walker A/P-loop; other site 585395005528 ATP binding site [chemical binding]; other site 585395005529 Q-loop/lid; other site 585395005530 ABC transporter signature motif; other site 585395005531 Walker B; other site 585395005532 D-loop; other site 585395005533 H-loop/switch region; other site 585395005534 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 585395005535 putative ABC transporter; Region: ycf24; CHL00085 585395005536 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 585395005537 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585395005538 CoenzymeA binding site [chemical binding]; other site 585395005539 subunit interaction site [polypeptide binding]; other site 585395005540 PHB binding site; other site 585395005541 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 585395005542 FAD binding domain; Region: FAD_binding_4; pfam01565 585395005543 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 585395005544 putative inner membrane protein; Provisional; Region: PRK10983 585395005545 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585395005546 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 585395005547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395005548 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585395005549 putative substrate translocation pore; other site 585395005550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395005551 putative substrate translocation pore; other site 585395005552 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 585395005553 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 585395005554 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 585395005555 shikimate binding site; other site 585395005556 NAD(P) binding site [chemical binding]; other site 585395005557 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 585395005558 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 585395005559 active site 585395005560 catalytic residue [active] 585395005561 dimer interface [polypeptide binding]; other site 585395005562 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 585395005563 Coenzyme A transferase; Region: CoA_trans; smart00882 585395005564 Coenzyme A transferase; Region: CoA_trans; cl17247 585395005565 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 585395005566 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 585395005567 active site 585395005568 predicted DNA-binding transcriptional regulator, ARAC-type, C-terminal part 585395005569 predicted DNA-binding transcriptional regulator, ARAC-type, N-terminal part 585395005570 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 585395005571 Ligand binding site [chemical binding]; other site 585395005572 Electron transfer flavoprotein domain; Region: ETF; pfam01012 585395005573 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 585395005574 Electron transfer flavoprotein domain; Region: ETF; smart00893 585395005575 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 585395005576 oxidoreductase; Provisional; Region: PRK10015 585395005577 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 585395005578 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 585395005579 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 585395005580 acyl-activating enzyme (AAE) consensus motif; other site 585395005581 putative AMP binding site [chemical binding]; other site 585395005582 putative active site [active] 585395005583 putative CoA binding site [chemical binding]; other site 585395005584 phosphoenolpyruvate synthase; Validated; Region: PRK06464 585395005585 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 585395005586 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585395005587 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585395005588 PEP synthetase regulatory protein; Provisional; Region: PRK05339 585395005589 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 585395005590 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585395005591 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 585395005592 Uncharacterized conserved protein [Function unknown]; Region: COG0397 585395005593 hypothetical protein; Validated; Region: PRK00029 585395005594 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 585395005595 NlpC/P60 family; Region: NLPC_P60; pfam00877 585395005596 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 585395005597 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585395005598 Walker A/P-loop; other site 585395005599 ATP binding site [chemical binding]; other site 585395005600 Q-loop/lid; other site 585395005601 ABC transporter signature motif; other site 585395005602 Walker B; other site 585395005603 D-loop; other site 585395005604 H-loop/switch region; other site 585395005605 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 585395005606 catalytic residues [active] 585395005607 dimer interface [polypeptide binding]; other site 585395005608 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585395005609 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585395005610 ABC-ATPase subunit interface; other site 585395005611 dimer interface [polypeptide binding]; other site 585395005612 putative PBP binding regions; other site 585395005613 Prophage ECO103_P07, P2-like phage 585395005614 TIGR03545 family protein; Region: TIGR03545 585395005615 integrase; Provisional; Region: int; PHA02601 585395005616 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585395005617 active site 585395005618 DNA binding site [nucleotide binding] 585395005619 Int/Topo IB signature motif; other site 585395005620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395005621 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585395005622 non-specific DNA binding site [nucleotide binding]; other site 585395005623 salt bridge; other site 585395005624 sequence-specific DNA binding site [nucleotide binding]; other site 585395005625 Transcriptional regulators [Transcription]; Region: MarR; COG1846 585395005626 MarR family; Region: MarR_2; pfam12802 585395005627 Ash protein family; Region: Phage_ASH; pfam10554 585395005628 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 585395005629 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 585395005630 Mg binding site [ion binding]; other site 585395005631 nucleotide binding site [chemical binding]; other site 585395005632 putative protofilament interface [polypeptide binding]; other site 585395005633 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 585395005634 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585395005635 Phage-related protein [Function unknown]; Region: COG4695; cl01923 585395005636 Phage portal protein; Region: Phage_portal; pfam04860 585395005637 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 585395005638 terminase ATPase subunit; Provisional; Region: P; PHA02535 585395005639 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 585395005640 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 585395005641 terminase endonuclease subunit; Provisional; Region: M; PHA02537 585395005642 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 585395005643 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 585395005644 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 585395005645 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 585395005646 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 585395005647 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 585395005648 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 585395005649 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 585395005650 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 585395005651 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 585395005652 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 585395005653 Baseplate J-like protein; Region: Baseplate_J; cl01294 585395005654 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 585395005655 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 585395005656 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585395005657 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585395005658 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585395005659 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585395005660 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 585395005661 multiple promoter invertase; Provisional; Region: mpi; PRK13413 585395005662 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 585395005663 catalytic residues [active] 585395005664 catalytic nucleophile [active] 585395005665 Presynaptic Site I dimer interface [polypeptide binding]; other site 585395005666 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 585395005667 Synaptic Flat tetramer interface [polypeptide binding]; other site 585395005668 Synaptic Site I dimer interface [polypeptide binding]; other site 585395005669 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 585395005670 DNA-binding interface [nucleotide binding]; DNA binding site 585395005671 Phage protein U [General function prediction only]; Region: COG3499 585395005672 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 585395005673 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 585395005674 Phage tail tube protein FII; Region: Phage_tube; cl01390 585395005675 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 585395005676 tail protein; Provisional; Region: D; PHA02561 585395005677 Protein of unknown function DUF262; Region: DUF262; pfam03235 585395005678 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585395005679 active site 585395005680 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 585395005681 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 585395005682 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585395005683 IHF dimer interface [polypeptide binding]; other site 585395005684 IHF - DNA interface [nucleotide binding]; other site 585395005685 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 585395005686 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 585395005687 putative tRNA-binding site [nucleotide binding]; other site 585395005688 B3/4 domain; Region: B3_4; pfam03483 585395005689 tRNA synthetase B5 domain; Region: B5; smart00874 585395005690 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 585395005691 dimer interface [polypeptide binding]; other site 585395005692 motif 1; other site 585395005693 motif 3; other site 585395005694 motif 2; other site 585395005695 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 585395005696 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 585395005697 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 585395005698 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 585395005699 dimer interface [polypeptide binding]; other site 585395005700 motif 1; other site 585395005701 active site 585395005702 motif 2; other site 585395005703 motif 3; other site 585395005704 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 585395005705 23S rRNA binding site [nucleotide binding]; other site 585395005706 L21 binding site [polypeptide binding]; other site 585395005707 L13 binding site [polypeptide binding]; other site 585395005708 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 585395005709 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 585395005710 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 585395005711 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 585395005712 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 585395005713 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 585395005714 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 585395005715 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 585395005716 active site 585395005717 dimer interface [polypeptide binding]; other site 585395005718 motif 1; other site 585395005719 motif 2; other site 585395005720 motif 3; other site 585395005721 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 585395005722 anticodon binding site; other site 585395005723 T3SS effector-like protein EspL-homolog, N-terminal part 585395005724 T3SS effector-like protein EspL-homolog, C-terminal part 585395005725 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 585395005726 6-phosphofructokinase 2; Provisional; Region: PRK10294 585395005727 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 585395005728 putative substrate binding site [chemical binding]; other site 585395005729 putative ATP binding site [chemical binding]; other site 585395005730 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 585395005731 Phosphotransferase enzyme family; Region: APH; pfam01636 585395005732 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 585395005733 active site 585395005734 ATP binding site [chemical binding]; other site 585395005735 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 585395005736 YniB-like protein; Region: YniB; pfam14002 585395005737 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 585395005738 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 585395005739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395005740 motif II; other site 585395005741 inner membrane protein; Provisional; Region: PRK11648 585395005742 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 585395005743 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585395005744 conserved predicted protein, C-terminal part 585395005745 conserved predicted protein, N-terminal part 585395005746 cell division modulator; Provisional; Region: PRK10113 585395005747 hydroperoxidase II; Provisional; Region: katE; PRK11249 585395005748 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 585395005749 tetramer interface [polypeptide binding]; other site 585395005750 heme binding pocket [chemical binding]; other site 585395005751 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 585395005752 domain interactions; other site 585395005753 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 585395005754 putative active site [active] 585395005755 YdjC motif; other site 585395005756 Mg binding site [ion binding]; other site 585395005757 putative homodimer interface [polypeptide binding]; other site 585395005758 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 585395005759 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 585395005760 NAD binding site [chemical binding]; other site 585395005761 sugar binding site [chemical binding]; other site 585395005762 divalent metal binding site [ion binding]; other site 585395005763 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585395005764 dimer interface [polypeptide binding]; other site 585395005765 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 585395005766 Cupin domain; Region: Cupin_2; pfam07883 585395005767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395005768 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 585395005769 methionine cluster; other site 585395005770 active site 585395005771 phosphorylation site [posttranslational modification] 585395005772 metal binding site [ion binding]; metal-binding site 585395005773 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 585395005774 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 585395005775 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 585395005776 active site 585395005777 P-loop; other site 585395005778 phosphorylation site [posttranslational modification] 585395005779 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 585395005780 NAD+ synthetase; Region: nadE; TIGR00552 585395005781 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 585395005782 homodimer interface [polypeptide binding]; other site 585395005783 NAD binding pocket [chemical binding]; other site 585395005784 ATP binding pocket [chemical binding]; other site 585395005785 Mg binding site [ion binding]; other site 585395005786 active-site loop [active] 585395005787 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 585395005788 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 585395005789 GIY-YIG motif/motif A; other site 585395005790 active site 585395005791 catalytic site [active] 585395005792 putative DNA binding site [nucleotide binding]; other site 585395005793 metal binding site [ion binding]; metal-binding site 585395005794 hypothetical protein; Provisional; Region: PRK11396 585395005795 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 585395005796 dimer interface [polypeptide binding]; other site 585395005797 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 585395005798 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 585395005799 putative active site [active] 585395005800 Zn binding site [ion binding]; other site 585395005801 succinylarginine dihydrolase; Provisional; Region: PRK13281 585395005802 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 585395005803 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 585395005804 NAD(P) binding site [chemical binding]; other site 585395005805 catalytic residues [active] 585395005806 arginine succinyltransferase; Provisional; Region: PRK10456 585395005807 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 585395005808 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 585395005809 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585395005810 inhibitor-cofactor binding pocket; inhibition site 585395005811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395005812 catalytic residue [active] 585395005813 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 585395005814 putative catalytic site [active] 585395005815 putative phosphate binding site [ion binding]; other site 585395005816 active site 585395005817 metal binding site A [ion binding]; metal-binding site 585395005818 DNA binding site [nucleotide binding] 585395005819 putative AP binding site [nucleotide binding]; other site 585395005820 putative metal binding site B [ion binding]; other site 585395005821 Uncharacterized conserved protein [Function unknown]; Region: COG0398 585395005822 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585395005823 Uncharacterized conserved protein [Function unknown]; Region: COG0398 585395005824 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585395005825 Uncharacterized conserved protein [Function unknown]; Region: COG2128 585395005826 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 585395005827 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 585395005828 hypothetical protein; Provisional; Region: PRK11622 585395005829 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 585395005830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395005831 dimer interface [polypeptide binding]; other site 585395005832 conserved gate region; other site 585395005833 putative PBP binding loops; other site 585395005834 ABC-ATPase subunit interface; other site 585395005835 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 585395005836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395005837 Walker A/P-loop; other site 585395005838 ATP binding site [chemical binding]; other site 585395005839 Q-loop/lid; other site 585395005840 ABC transporter signature motif; other site 585395005841 Walker B; other site 585395005842 D-loop; other site 585395005843 H-loop/switch region; other site 585395005844 Rhodanese Homology Domain; Region: RHOD; smart00450 585395005845 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 585395005846 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 585395005847 active site residue [active] 585395005848 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 585395005849 active site residue [active] 585395005850 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 585395005851 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 585395005852 active site 585395005853 8-oxo-dGMP binding site [chemical binding]; other site 585395005854 nudix motif; other site 585395005855 metal binding site [ion binding]; metal-binding site 585395005856 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 585395005857 glutamate dehydrogenase; Provisional; Region: PRK09414 585395005858 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 585395005859 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 585395005860 NAD(P) binding site [chemical binding]; other site 585395005861 predicted inner membrane protein, C-terminal part 585395005862 predicted inner membrane protein, N-terminal part 585395005863 DNA topoisomerase III; Provisional; Region: PRK07726 585395005864 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 585395005865 active site 585395005866 putative interdomain interaction site [polypeptide binding]; other site 585395005867 putative metal-binding site [ion binding]; other site 585395005868 putative nucleotide binding site [chemical binding]; other site 585395005869 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 585395005870 domain I; other site 585395005871 DNA binding groove [nucleotide binding] 585395005872 phosphate binding site [ion binding]; other site 585395005873 domain II; other site 585395005874 domain III; other site 585395005875 nucleotide binding site [chemical binding]; other site 585395005876 catalytic site [active] 585395005877 domain IV; other site 585395005878 selenophosphate synthetase; Provisional; Region: PRK00943 585395005879 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 585395005880 dimerization interface [polypeptide binding]; other site 585395005881 putative ATP binding site [chemical binding]; other site 585395005882 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 585395005883 putative FMN binding site [chemical binding]; other site 585395005884 protease 4; Provisional; Region: PRK10949 585395005885 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 585395005886 tandem repeat interface [polypeptide binding]; other site 585395005887 oligomer interface [polypeptide binding]; other site 585395005888 active site residues [active] 585395005889 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 585395005890 tandem repeat interface [polypeptide binding]; other site 585395005891 oligomer interface [polypeptide binding]; other site 585395005892 active site residues [active] 585395005893 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 585395005894 active site 585395005895 homodimer interface [polypeptide binding]; other site 585395005896 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 585395005897 Isochorismatase family; Region: Isochorismatase; pfam00857 585395005898 catalytic triad [active] 585395005899 metal binding site [ion binding]; metal-binding site 585395005900 conserved cis-peptide bond; other site 585395005901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 585395005902 methionine sulfoxide reductase B; Provisional; Region: PRK00222 585395005903 SelR domain; Region: SelR; pfam01641 585395005904 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 585395005905 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585395005906 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585395005907 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 585395005908 active site 585395005909 phosphate binding residues; other site 585395005910 catalytic residues [active] 585395005911 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585395005912 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585395005913 active site 585395005914 catalytic tetrad [active] 585395005915 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 585395005916 PrkA family serine protein kinase; Provisional; Region: PRK15455 585395005917 AAA ATPase domain; Region: AAA_16; pfam13191 585395005918 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 585395005919 hypothetical protein; Provisional; Region: PRK05325 585395005920 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585395005921 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395005922 metal binding site [ion binding]; metal-binding site 585395005923 active site 585395005924 I-site; other site 585395005925 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585395005926 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395005927 metal binding site [ion binding]; metal-binding site 585395005928 active site 585395005929 I-site; other site 585395005930 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 585395005931 putative deacylase active site [active] 585395005932 Predicted membrane protein [Function unknown]; Region: COG2707 585395005933 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585395005934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395005935 cyanate transporter; Region: CynX; TIGR00896 585395005936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395005937 putative substrate translocation pore; other site 585395005938 Uncharacterized conserved protein [Function unknown]; Region: COG3189 585395005939 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 585395005940 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 585395005941 Domain of unknown function (DUF333); Region: DUF333; pfam03891 585395005942 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 585395005943 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585395005944 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585395005945 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395005946 metal binding site [ion binding]; metal-binding site 585395005947 active site 585395005948 I-site; other site 585395005949 hypothetical protein; Provisional; Region: PRK10457 585395005950 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 585395005951 Probable transposase; Region: OrfB_IS605; pfam01385 585395005952 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 585395005953 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 585395005954 Transposase IS200 like; Region: Y1_Tnp; pfam01797 585395005955 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 585395005956 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 585395005957 leucine export protein LeuE; Provisional; Region: PRK10958 585395005958 transcriptional activator TtdR; Provisional; Region: PRK09801 585395005959 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395005960 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 585395005961 putative effector binding pocket; other site 585395005962 putative dimerization interface [polypeptide binding]; other site 585395005963 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 585395005964 tartrate dehydrogenase; Region: TTC; TIGR02089 585395005965 putative transporter; Provisional; Region: PRK09950 585395005966 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 585395005967 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 585395005968 [2Fe-2S] cluster binding site [ion binding]; other site 585395005969 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 585395005970 putative alpha subunit interface [polypeptide binding]; other site 585395005971 putative active site [active] 585395005972 putative substrate binding site [chemical binding]; other site 585395005973 Fe binding site [ion binding]; other site 585395005974 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 585395005975 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 585395005976 FMN-binding pocket [chemical binding]; other site 585395005977 flavin binding motif; other site 585395005978 phosphate binding motif [ion binding]; other site 585395005979 beta-alpha-beta structure motif; other site 585395005980 NAD binding pocket [chemical binding]; other site 585395005981 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585395005982 catalytic loop [active] 585395005983 iron binding site [ion binding]; other site 585395005984 ribonuclease D; Provisional; Region: PRK10829 585395005985 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 585395005986 catalytic site [active] 585395005987 putative active site [active] 585395005988 putative substrate binding site [chemical binding]; other site 585395005989 Helicase and RNase D C-terminal; Region: HRDC; smart00341 585395005990 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 585395005991 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 585395005992 acyl-activating enzyme (AAE) consensus motif; other site 585395005993 putative AMP binding site [chemical binding]; other site 585395005994 putative active site [active] 585395005995 putative CoA binding site [chemical binding]; other site 585395005996 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 585395005997 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 585395005998 Glycoprotease family; Region: Peptidase_M22; pfam00814 585395005999 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 585395006000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 585395006001 DEAD_2; Region: DEAD_2; pfam06733 585395006002 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 585395006003 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 585395006004 homotrimer interaction site [polypeptide binding]; other site 585395006005 putative active site [active] 585395006006 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 585395006007 hypothetical protein; Provisional; Region: PRK05114 585395006008 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 585395006009 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 585395006010 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 585395006011 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 585395006012 putative active site [active] 585395006013 putative CoA binding site [chemical binding]; other site 585395006014 nudix motif; other site 585395006015 metal binding site [ion binding]; metal-binding site 585395006016 L-serine deaminase; Provisional; Region: PRK15023 585395006017 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585395006018 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585395006019 phage resistance protein; Provisional; Region: PRK10551 585395006020 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585395006021 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395006022 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585395006023 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 585395006024 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585395006025 Transporter associated domain; Region: CorC_HlyC; smart01091 585395006026 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 585395006027 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585395006028 active pocket/dimerization site; other site 585395006029 active site 585395006030 phosphorylation site [posttranslational modification] 585395006031 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585395006032 active site 585395006033 phosphorylation site [posttranslational modification] 585395006034 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 585395006035 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 585395006036 Predicted membrane protein [Function unknown]; Region: COG4811 585395006037 hypothetical protein; Provisional; Region: PRK11469 585395006038 Domain of unknown function DUF; Region: DUF204; pfam02659 585395006039 Domain of unknown function DUF; Region: DUF204; pfam02659 585395006040 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 585395006041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395006042 S-adenosylmethionine binding site [chemical binding]; other site 585395006043 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585395006044 DNA-binding site [nucleotide binding]; DNA binding site 585395006045 RNA-binding motif; other site 585395006046 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 585395006047 YebO-like protein; Region: YebO; pfam13974 585395006048 PhoPQ regulatory protein; Provisional; Region: PRK10299 585395006049 YobH-like protein; Region: YobH; pfam13996 585395006050 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 585395006051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585395006052 dimerization interface [polypeptide binding]; other site 585395006053 putative Zn2+ binding site [ion binding]; other site 585395006054 putative DNA binding site [nucleotide binding]; other site 585395006055 Bacterial transcriptional regulator; Region: IclR; pfam01614 585395006056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395006057 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585395006058 putative substrate translocation pore; other site 585395006059 Predicted integral membrane protein [Function unknown]; Region: COG5521 585395006060 heat shock protein HtpX; Provisional; Region: PRK05457 585395006061 carboxy-terminal protease; Provisional; Region: PRK11186 585395006062 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 585395006063 protein binding site [polypeptide binding]; other site 585395006064 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 585395006065 Catalytic dyad [active] 585395006066 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 585395006067 ProP expression regulator; Provisional; Region: PRK04950 585395006068 ProQ/FINO family; Region: ProQ; pfam04352 585395006069 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 585395006070 GAF domain; Region: GAF_2; pfam13185 585395006071 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 585395006072 Paraquat-inducible protein A; Region: PqiA; pfam04403 585395006073 Paraquat-inducible protein A; Region: PqiA; pfam04403 585395006074 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 585395006075 mce related protein; Region: MCE; pfam02470 585395006076 mce related protein; Region: MCE; pfam02470 585395006077 mce related protein; Region: MCE; pfam02470 585395006078 mce related protein; Region: MCE; pfam02470 585395006079 mce related protein; Region: MCE; pfam02470 585395006080 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 585395006081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395006082 S-adenosylmethionine binding site [chemical binding]; other site 585395006083 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 585395006084 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 585395006085 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585395006086 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 585395006087 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585395006088 active site 585395006089 metal binding site [ion binding]; metal-binding site 585395006090 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 585395006091 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 585395006092 hypothetical protein; Provisional; Region: PRK10301 585395006093 Predicted amidohydrolase [General function prediction only]; Region: COG0388 585395006094 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 585395006095 exodeoxyribonuclease X; Provisional; Region: PRK07983 585395006096 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 585395006097 active site 585395006098 catalytic site [active] 585395006099 substrate binding site [chemical binding]; other site 585395006100 protease 2; Provisional; Region: PRK10115 585395006101 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585395006102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 585395006103 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 585395006104 putative metal binding site [ion binding]; other site 585395006105 conserved predicted protein, N-terminal part 585395006106 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 585395006107 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 585395006108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585395006109 ATP-grasp domain; Region: ATP-grasp; pfam02222 585395006110 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 585395006111 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 585395006112 active site 585395006113 intersubunit interface [polypeptide binding]; other site 585395006114 catalytic residue [active] 585395006115 phosphogluconate dehydratase; Validated; Region: PRK09054 585395006116 6-phosphogluconate dehydratase; Region: edd; TIGR01196 585395006117 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 585395006118 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 585395006119 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 585395006120 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 585395006121 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585395006122 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585395006123 putative active site [active] 585395006124 pyruvate kinase; Provisional; Region: PRK05826 585395006125 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 585395006126 domain interfaces; other site 585395006127 active site 585395006128 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585395006129 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585395006130 putative acyl-acceptor binding pocket; other site 585395006131 putative peptidase; Provisional; Region: PRK11649 585395006132 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 585395006133 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585395006134 Peptidase family M23; Region: Peptidase_M23; pfam01551 585395006135 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 585395006136 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 585395006137 metal binding site [ion binding]; metal-binding site 585395006138 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 585395006139 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 585395006140 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 585395006141 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585395006142 ABC-ATPase subunit interface; other site 585395006143 dimer interface [polypeptide binding]; other site 585395006144 putative PBP binding regions; other site 585395006145 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 585395006146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395006147 Walker A motif; other site 585395006148 ATP binding site [chemical binding]; other site 585395006149 Walker B motif; other site 585395006150 arginine finger; other site 585395006151 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 585395006152 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 585395006153 RuvA N terminal domain; Region: RuvA_N; pfam01330 585395006154 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 585395006155 conserved predicted protein, N-terminal part 585395006156 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 585395006157 active site 585395006158 putative DNA-binding cleft [nucleotide binding]; other site 585395006159 dimer interface [polypeptide binding]; other site 585395006160 hypothetical protein; Validated; Region: PRK00110 585395006161 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 585395006162 nudix motif; other site 585395006163 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 585395006164 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 585395006165 dimer interface [polypeptide binding]; other site 585395006166 anticodon binding site; other site 585395006167 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 585395006168 homodimer interface [polypeptide binding]; other site 585395006169 motif 1; other site 585395006170 active site 585395006171 motif 2; other site 585395006172 GAD domain; Region: GAD; pfam02938 585395006173 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 585395006174 motif 3; other site 585395006175 Isochorismatase family; Region: Isochorismatase; pfam00857 585395006176 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 585395006177 catalytic triad [active] 585395006178 conserved cis-peptide bond; other site 585395006179 Prophage ECO103_P08, lambda-like phage 585395006180 DinI-like family; Region: DinI; pfam06183 585395006181 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 585395006182 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585395006183 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585395006184 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585395006185 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395006186 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585395006187 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395006188 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585395006189 Phage-related protein, tail component [Function unknown]; Region: COG4733 585395006190 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585395006191 Fibronectin type 3 domain; Region: FN3; smart00060 585395006192 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585395006193 Fibronectin type III protein; Region: DUF3672; pfam12421 585395006194 Phage-related protein, tail component [Function unknown]; Region: COG4723 585395006195 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585395006196 MPN+ (JAMM) motif; other site 585395006197 Zinc-binding site [ion binding]; other site 585395006198 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585395006199 NlpC/P60 family; Region: NLPC_P60; cl17555 585395006200 Phage-related protein [Function unknown]; Region: gp18; COG4672 585395006201 Phage-related protein [Function unknown]; Region: COG4718 585395006202 Phage-related minor tail protein [Function unknown]; Region: COG5281 585395006203 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585395006204 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585395006205 Minor tail protein T; Region: Phage_tail_T; cl05636 585395006206 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 585395006207 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585395006208 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585395006209 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585395006210 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585395006211 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 585395006212 DNA packaging protein FI; Region: Packaging_FI; pfam14000 585395006213 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585395006214 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585395006215 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 585395006216 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 585395006217 tandem repeat interface [polypeptide binding]; other site 585395006218 oligomer interface [polypeptide binding]; other site 585395006219 active site residues [active] 585395006220 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585395006221 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585395006222 gpW; Region: gpW; pfam02831 585395006223 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585395006224 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 585395006225 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585395006226 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585395006227 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585395006228 catalytic residues [active] 585395006229 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 585395006230 Lysis protein S; Region: Lysis_S; pfam04971 585395006231 Prophage ECO103_P08; conserved predicted protein, C-terminal part 585395006232 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 585395006233 tellurite resistance protein terB; Region: terB; cd07176 585395006234 putative metal binding site [ion binding]; other site 585395006235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395006236 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585395006237 DNA methylase; Region: N6_N4_Mtase; pfam01555 585395006238 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585395006239 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 585395006240 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585395006241 replicative DNA helicase; Region: DnaB; TIGR00665 585395006242 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 585395006243 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 585395006244 Walker A motif; other site 585395006245 ATP binding site [chemical binding]; other site 585395006246 Walker B motif; other site 585395006247 DNA binding loops [nucleotide binding] 585395006248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 585395006249 Walker A motif; other site 585395006250 ATP binding site [chemical binding]; other site 585395006251 Walker B motif; other site 585395006252 arginine finger; other site 585395006253 Ash protein family; Region: Phage_ASH; pfam10554 585395006254 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585395006255 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585395006256 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 585395006257 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395006258 non-specific DNA binding site [nucleotide binding]; other site 585395006259 Predicted transcriptional regulator [Transcription]; Region: COG2932 585395006260 salt bridge; other site 585395006261 sequence-specific DNA binding site [nucleotide binding]; other site 585395006262 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585395006263 Catalytic site [active] 585395006264 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 585395006265 non-specific DNA binding site [nucleotide binding]; other site 585395006266 salt bridge; other site 585395006267 sequence-specific DNA binding site [nucleotide binding]; other site 585395006268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395006269 non-specific DNA binding site [nucleotide binding]; other site 585395006270 salt bridge; other site 585395006271 sequence-specific DNA binding site [nucleotide binding]; other site 585395006272 putative transposase OrfB; Reviewed; Region: PHA02517 585395006273 HTH-like domain; Region: HTH_21; pfam13276 585395006274 Integrase core domain; Region: rve; pfam00665 585395006275 Integrase core domain; Region: rve_3; pfam13683 585395006276 Transposase; Region: HTH_Tnp_1; cl17663 585395006277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395006278 Prophage ECO103_P08; conserved predicted protein, C-terminal part 585395006279 Prophage ECO103_P08; predicted serine protease, N-terminal fragment 585395006280 Prophage ECO103_P08; predicted serine protease, C-terminal fragment 585395006281 Transposase; Region: HTH_Tnp_1; cl17663 585395006282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395006283 putative transposase OrfB; Reviewed; Region: PHA02517 585395006284 HTH-like domain; Region: HTH_21; pfam13276 585395006285 Integrase core domain; Region: rve; pfam00665 585395006286 Integrase core domain; Region: rve_3; pfam13683 585395006287 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 585395006288 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 585395006289 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 585395006290 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585395006291 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 585395006292 Int/Topo IB signature motif; other site 585395006293 conserved predicted protein, partial 585395006294 putative transposase OrfB; Reviewed; Region: PHA02517 585395006295 HTH-like domain; Region: HTH_21; pfam13276 585395006296 Integrase core domain; Region: rve; pfam00665 585395006297 Integrase core domain; Region: rve_3; pfam13683 585395006298 Transposase; Region: HTH_Tnp_1; cl17663 585395006299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395006300 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 585395006301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395006302 S-adenosylmethionine binding site [chemical binding]; other site 585395006303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395006304 S-adenosylmethionine binding site [chemical binding]; other site 585395006305 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585395006306 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585395006307 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 585395006308 molybdopterin cofactor binding site [chemical binding]; other site 585395006309 substrate binding site [chemical binding]; other site 585395006310 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585395006311 molybdopterin cofactor binding site; other site 585395006312 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 585395006313 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 585395006314 copper homeostasis protein CutC; Provisional; Region: PRK11572 585395006315 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 585395006316 putative metal binding site [ion binding]; other site 585395006317 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 585395006318 arginyl-tRNA synthetase; Region: argS; TIGR00456 585395006319 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 585395006320 active site 585395006321 HIGH motif; other site 585395006322 KMSK motif region; other site 585395006323 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 585395006324 tRNA binding surface [nucleotide binding]; other site 585395006325 anticodon binding site; other site 585395006326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 585395006327 Flagellar protein FlhE; Region: FlhE; pfam06366 585395006328 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 585395006329 FHIPEP family; Region: FHIPEP; pfam00771 585395006330 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 585395006331 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 585395006332 chemotaxis regulator CheZ; Provisional; Region: PRK11166 585395006333 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 585395006334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395006335 active site 585395006336 phosphorylation site [posttranslational modification] 585395006337 intermolecular recognition site; other site 585395006338 dimerization interface [polypeptide binding]; other site 585395006339 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 585395006340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395006341 active site 585395006342 phosphorylation site [posttranslational modification] 585395006343 intermolecular recognition site; other site 585395006344 dimerization interface [polypeptide binding]; other site 585395006345 CheB methylesterase; Region: CheB_methylest; pfam01339 585395006346 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 585395006347 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 585395006348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395006349 S-adenosylmethionine binding site [chemical binding]; other site 585395006350 methyl-accepting protein IV; Provisional; Region: PRK09793 585395006351 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585395006352 dimer interface [polypeptide binding]; other site 585395006353 ligand binding site [chemical binding]; other site 585395006354 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585395006355 dimerization interface [polypeptide binding]; other site 585395006356 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585395006357 dimer interface [polypeptide binding]; other site 585395006358 putative CheW interface [polypeptide binding]; other site 585395006359 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 585395006360 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585395006361 dimer interface [polypeptide binding]; other site 585395006362 ligand binding site [chemical binding]; other site 585395006363 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585395006364 dimerization interface [polypeptide binding]; other site 585395006365 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585395006366 dimer interface [polypeptide binding]; other site 585395006367 putative CheW interface [polypeptide binding]; other site 585395006368 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 585395006369 putative CheA interaction surface; other site 585395006370 chemotaxis protein CheA; Provisional; Region: PRK10547 585395006371 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585395006372 putative binding surface; other site 585395006373 active site 585395006374 CheY binding; Region: CheY-binding; pfam09078 585395006375 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 585395006376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395006377 ATP binding site [chemical binding]; other site 585395006378 Mg2+ binding site [ion binding]; other site 585395006379 G-X-G motif; other site 585395006380 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 585395006381 flagellar motor protein MotB; Validated; Region: motB; PRK09041 585395006382 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 585395006383 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585395006384 ligand binding site [chemical binding]; other site 585395006385 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 585395006386 flagellar motor protein MotA; Validated; Region: PRK09110 585395006387 transcriptional activator FlhC; Provisional; Region: PRK12722 585395006388 transcriptional activator FlhD; Provisional; Region: PRK02909 585395006389 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585395006390 Ligand Binding Site [chemical binding]; other site 585395006391 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 585395006392 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 585395006393 active site 585395006394 homotetramer interface [polypeptide binding]; other site 585395006395 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 585395006396 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 585395006397 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585395006398 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585395006399 TM-ABC transporter signature motif; other site 585395006400 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 585395006401 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585395006402 Walker A/P-loop; other site 585395006403 ATP binding site [chemical binding]; other site 585395006404 Q-loop/lid; other site 585395006405 ABC transporter signature motif; other site 585395006406 Walker B; other site 585395006407 D-loop; other site 585395006408 H-loop/switch region; other site 585395006409 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585395006410 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 585395006411 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 585395006412 ligand binding site [chemical binding]; other site 585395006413 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 585395006414 Ferritin-like domain; Region: Ferritin; pfam00210 585395006415 ferroxidase diiron center [ion binding]; other site 585395006416 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 585395006417 YecR-like lipoprotein; Region: YecR; pfam13992 585395006418 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 585395006419 Ferritin-like domain; Region: Ferritin; pfam00210 585395006420 ferroxidase diiron center [ion binding]; other site 585395006421 probable metal-binding protein; Region: matur_matur; TIGR03853 585395006422 tyrosine transporter TyrP; Provisional; Region: PRK15132 585395006423 aromatic amino acid transport protein; Region: araaP; TIGR00837 585395006424 hypothetical protein; Provisional; Region: PRK10396 585395006425 yecA family protein; Region: ygfB_yecA; TIGR02292 585395006426 SEC-C motif; Region: SEC-C; pfam02810 585395006427 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 585395006428 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 585395006429 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 585395006430 GIY-YIG motif/motif A; other site 585395006431 active site 585395006432 catalytic site [active] 585395006433 putative DNA binding site [nucleotide binding]; other site 585395006434 metal binding site [ion binding]; metal-binding site 585395006435 UvrB/uvrC motif; Region: UVR; pfam02151 585395006436 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 585395006437 Helix-hairpin-helix motif; Region: HHH; pfam00633 585395006438 response regulator; Provisional; Region: PRK09483 585395006439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395006440 active site 585395006441 phosphorylation site [posttranslational modification] 585395006442 intermolecular recognition site; other site 585395006443 dimerization interface [polypeptide binding]; other site 585395006444 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395006445 DNA binding residues [nucleotide binding] 585395006446 dimerization interface [polypeptide binding]; other site 585395006447 hypothetical protein; Provisional; Region: PRK10613 585395006448 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 585395006449 Autoinducer binding domain; Region: Autoind_bind; pfam03472 585395006450 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395006451 DNA binding residues [nucleotide binding] 585395006452 dimerization interface [polypeptide binding]; other site 585395006453 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 585395006454 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585395006455 Walker A/P-loop; other site 585395006456 ATP binding site [chemical binding]; other site 585395006457 Q-loop/lid; other site 585395006458 ABC transporter signature motif; other site 585395006459 Walker B; other site 585395006460 D-loop; other site 585395006461 H-loop/switch region; other site 585395006462 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585395006463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395006464 dimer interface [polypeptide binding]; other site 585395006465 conserved gate region; other site 585395006466 putative PBP binding loops; other site 585395006467 ABC-ATPase subunit interface; other site 585395006468 D-cysteine desulfhydrase; Validated; Region: PRK03910 585395006469 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 585395006470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395006471 catalytic residue [active] 585395006472 cystine transporter subunit; Provisional; Region: PRK11260 585395006473 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395006474 substrate binding pocket [chemical binding]; other site 585395006475 membrane-bound complex binding site; other site 585395006476 hinge residues; other site 585395006477 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 585395006478 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 585395006479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585395006480 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585395006481 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585395006482 DNA binding residues [nucleotide binding] 585395006483 flagellin; Validated; Region: PRK08026 585395006484 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 585395006485 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 585395006486 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 585395006487 flagellar capping protein; Reviewed; Region: fliD; PRK08032 585395006488 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 585395006489 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 585395006490 Flagellar protein FliS; Region: FliS; cl00654 585395006491 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 585395006492 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 585395006493 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 585395006494 active site 585395006495 Na/Ca binding site [ion binding]; other site 585395006496 catalytic site [active] 585395006497 lipoprotein; Provisional; Region: PRK10397 585395006498 putative inner membrane protein; Provisional; Region: PRK11099 585395006499 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 585395006500 CPxP motif; other site 585395006501 hypothetical protein; Provisional; Region: PRK09951 585395006502 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 585395006503 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 585395006504 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 585395006505 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 585395006506 flagellar motor switch protein FliG; Region: fliG; TIGR00207 585395006507 FliG C-terminal domain; Region: FliG_C; pfam01706 585395006508 flagellar assembly protein H; Validated; Region: fliH; PRK05687 585395006509 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 585395006510 Flagellar assembly protein FliH; Region: FliH; pfam02108 585395006511 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 585395006512 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 585395006513 Walker A motif/ATP binding site; other site 585395006514 Walker B motif; other site 585395006515 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 585395006516 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 585395006517 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 585395006518 flagellar hook-length control protein; Provisional; Region: PRK10118 585395006519 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 585395006520 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 585395006521 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 585395006522 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 585395006523 flagellar motor switch protein; Validated; Region: fliN; PRK05698 585395006524 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 585395006525 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 585395006526 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 585395006527 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 585395006528 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 585395006529 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395006530 DNA binding residues [nucleotide binding] 585395006531 dimerization interface [polypeptide binding]; other site 585395006532 hypothetical protein; Provisional; Region: PRK10708 585395006533 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 585395006534 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 585395006535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395006536 active site 585395006537 motif I; other site 585395006538 motif II; other site 585395006539 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 585395006540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395006541 metal binding site [ion binding]; metal-binding site 585395006542 active site 585395006543 I-site; other site 585395006544 Uncharacterized small protein [Function unknown]; Region: COG5475 585395006545 hypothetical protein; Provisional; Region: PRK10062 585395006546 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 585395006547 EamA-like transporter family; Region: EamA; pfam00892 585395006548 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 585395006549 additional DNA contacts [nucleotide binding]; other site 585395006550 mismatch recognition site; other site 585395006551 active site 585395006552 zinc binding site [ion binding]; other site 585395006553 DNA intercalation site [nucleotide binding]; other site 585395006554 DNA cytosine methylase; Provisional; Region: PRK10458 585395006555 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 585395006556 cofactor binding site; other site 585395006557 DNA binding site [nucleotide binding] 585395006558 substrate interaction site [chemical binding]; other site 585395006559 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 585395006560 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585395006561 Zn2+ binding site [ion binding]; other site 585395006562 Mg2+ binding site [ion binding]; other site 585395006563 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 585395006564 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585395006565 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585395006566 eyelet of channel; other site 585395006567 trimer interface [polypeptide binding]; other site 585395006568 chaperone protein HchA; Provisional; Region: PRK04155 585395006569 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 585395006570 dimer interface [polypeptide binding]; other site 585395006571 metal binding site [ion binding]; metal-binding site 585395006572 potential oxyanion hole; other site 585395006573 potential catalytic triad [active] 585395006574 conserved cys residue [active] 585395006575 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 585395006576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395006577 dimer interface [polypeptide binding]; other site 585395006578 phosphorylation site [posttranslational modification] 585395006579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395006580 ATP binding site [chemical binding]; other site 585395006581 Mg2+ binding site [ion binding]; other site 585395006582 G-X-G motif; other site 585395006583 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 585395006584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395006585 active site 585395006586 phosphorylation site [posttranslational modification] 585395006587 intermolecular recognition site; other site 585395006588 dimerization interface [polypeptide binding]; other site 585395006589 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395006590 DNA binding site [nucleotide binding] 585395006591 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 585395006592 active site 585395006593 homotetramer interface [polypeptide binding]; other site 585395006594 TMAO/DMSO reductase; Reviewed; Region: PRK05363 585395006595 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 585395006596 Moco binding site; other site 585395006597 metal coordination site [ion binding]; other site 585395006598 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 585395006599 zinc/cadmium-binding protein; Provisional; Region: PRK10306 585395006600 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 585395006601 Prophage ECO103_P09, lambda-like phage 585395006602 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 585395006603 Prophage ECO103_P09; T3SS effector NleH-like protein, C-terminal part 585395006604 Prophage ECO103_P09; T3SS effector NleH-like protein, C-terminal part 585395006605 Prophage ECO103_P09; T3SS effector NleC-like protein, N-terminal part 585395006606 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 585395006607 type III secretion system protein; Provisional; Region: PRK15384; cl14665 585395006608 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395006609 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585395006610 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585395006611 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395006612 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585395006613 Phage-related protein, tail component [Function unknown]; Region: COG4733 585395006614 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585395006615 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585395006616 Interdomain contacts; other site 585395006617 Cytokine receptor motif; other site 585395006618 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585395006619 Fibronectin type III protein; Region: DUF3672; pfam12421 585395006620 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 585395006621 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 585395006622 E-class dimer interface [polypeptide binding]; other site 585395006623 P-class dimer interface [polypeptide binding]; other site 585395006624 active site 585395006625 Cu2+ binding site [ion binding]; other site 585395006626 Zn2+ binding site [ion binding]; other site 585395006627 Phage-related protein, tail component [Function unknown]; Region: COG4723 585395006628 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585395006629 MPN+ (JAMM) motif; other site 585395006630 Zinc-binding site [ion binding]; other site 585395006631 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585395006632 NlpC/P60 family; Region: NLPC_P60; cl17555 585395006633 Phage-related protein [Function unknown]; Region: gp18; COG4672 585395006634 Phage-related protein [Function unknown]; Region: COG4718 585395006635 Phage-related minor tail protein [Function unknown]; Region: COG5281 585395006636 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585395006637 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585395006638 Minor tail protein T; Region: Phage_tail_T; cl05636 585395006639 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 585395006640 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585395006641 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585395006642 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585395006643 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585395006644 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 585395006645 DNA packaging protein FI; Region: Packaging_FI; pfam14000 585395006646 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585395006647 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585395006648 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 585395006649 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 585395006650 tandem repeat interface [polypeptide binding]; other site 585395006651 oligomer interface [polypeptide binding]; other site 585395006652 active site residues [active] 585395006653 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585395006654 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585395006655 gpW; Region: gpW; pfam02831 585395006656 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585395006657 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 585395006658 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 585395006659 PerC transcriptional activator; Region: PerC; pfam06069 585395006660 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585395006661 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585395006662 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585395006663 catalytic residues [active] 585395006664 Lysis protein S; Region: Lysis_S; pfam04971 585395006665 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585395006666 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585395006667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585395006668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395006669 CAAX protease self-immunity; Region: Abi; pfam02517 585395006670 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585395006671 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585395006672 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585395006673 Hok/gef family; Region: HOK_GEF; pfam01848 585395006674 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585395006675 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 585395006676 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 585395006677 putative replication protein; Provisional; Region: PRK12377 585395006678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395006679 Walker A motif; other site 585395006680 ATP binding site [chemical binding]; other site 585395006681 Walker B motif; other site 585395006682 arginine finger; other site 585395006683 primosomal protein DnaI; Provisional; Region: PRK02854 585395006684 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585395006685 transcriptional repressor DicA; Reviewed; Region: PRK09706 585395006686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395006687 non-specific DNA binding site [nucleotide binding]; other site 585395006688 salt bridge; other site 585395006689 sequence-specific DNA binding site [nucleotide binding]; other site 585395006690 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 585395006691 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 585395006692 DicB protein; Region: DicB; pfam05358 585395006693 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585395006694 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 585395006695 active site 585395006696 catalytic site [active] 585395006697 substrate binding site [chemical binding]; other site 585395006698 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585395006699 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 585395006700 dimer interface [polypeptide binding]; other site 585395006701 active site 585395006702 Int/Topo IB signature motif; other site 585395006703 Prophage ECO103_P10, lambda-like phage 585395006704 type III secretion protein GogB; Provisional; Region: PRK15386 585395006705 magnesiumprotoporphyrin-IX chelatase subunit H; Provisional; Region: PLN03069 585395006706 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395006707 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 585395006708 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585395006709 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585395006710 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585395006711 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585395006712 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585395006713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585395006714 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585395006715 Transposase; Region: HTH_Tnp_1; pfam01527 585395006716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395006717 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585395006718 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585395006719 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395006720 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585395006721 Phage-related protein, tail component [Function unknown]; Region: COG4733 585395006722 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585395006723 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585395006724 Interdomain contacts; other site 585395006725 Cytokine receptor motif; other site 585395006726 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585395006727 Fibronectin type III protein; Region: DUF3672; pfam12421 585395006728 Phage-related protein, tail component [Function unknown]; Region: COG4723 585395006729 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585395006730 MPN+ (JAMM) motif; other site 585395006731 Zinc-binding site [ion binding]; other site 585395006732 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585395006733 NlpC/P60 family; Region: NLPC_P60; cl17555 585395006734 Phage-related protein [Function unknown]; Region: gp18; COG4672 585395006735 Phage-related protein [Function unknown]; Region: COG4718 585395006736 Phage-related minor tail protein [Function unknown]; Region: COG5281 585395006737 tape measure domain; Region: tape_meas_nterm; TIGR02675 585395006738 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 585395006739 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585395006740 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 585395006741 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 585395006742 Immunoglobulin I-set domain; Region: I-set; pfam07679 585395006743 Immunoglobulin domain; Region: Ig_2; pfam13895 585395006744 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 585395006745 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 585395006746 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 585395006747 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 585395006748 Phage-related protein [Function unknown]; Region: COG4695 585395006749 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 585395006750 Prophage ECO103_P10; predicted head protein/prohead protease, C-terminal part 585395006751 Prophage ECO103_P10; predicted head protein/prohead protease, N-terminal part 585395006752 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 585395006753 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 585395006754 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 585395006755 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585395006756 active site 585395006757 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 585395006758 PerC transcriptional activator; Region: PerC; pfam06069 585395006759 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585395006760 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585395006761 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 585395006762 ORF11CD3 domain; Region: ORF11CD3; pfam10549 585395006763 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585395006764 catalytic residues [active] 585395006765 Lysis protein S; Region: Lysis_S; pfam04971 585395006766 Protein of unknown function (DUF826); Region: DUF826; pfam05696 585395006767 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 585395006768 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585395006769 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585395006770 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 585395006771 tellurite resistance protein terB; Region: terB; cd07176 585395006772 putative metal binding site [ion binding]; other site 585395006773 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585395006774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395006775 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 585395006776 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585395006777 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585395006778 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 585395006779 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 585395006780 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585395006781 active site 585395006782 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 585395006783 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585395006784 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585395006785 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 585395006786 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 585395006787 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 585395006788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3756 585395006789 Pyocin large subunit [General function prediction only]; Region: COG5529 585395006790 primosomal protein DnaI; Provisional; Region: PRK02854 585395006791 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585395006792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395006793 sequence-specific DNA binding site [nucleotide binding]; other site 585395006794 salt bridge; other site 585395006795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395006796 transcriptional repressor DicA; Reviewed; Region: PRK09706 585395006797 non-specific DNA binding site [nucleotide binding]; other site 585395006798 salt bridge; other site 585395006799 sequence-specific DNA binding site [nucleotide binding]; other site 585395006800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395006801 non-specific DNA binding site [nucleotide binding]; other site 585395006802 salt bridge; other site 585395006803 sequence-specific DNA binding site [nucleotide binding]; other site 585395006804 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 585395006805 Prophage ECO103_P10; conserved predicted protein, C-terminal part 585395006806 DicB protein; Region: DicB; pfam05358 585395006807 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585395006808 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 585395006809 active site 585395006810 catalytic site [active] 585395006811 substrate binding site [chemical binding]; other site 585395006812 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585395006813 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 585395006814 dimer interface [polypeptide binding]; other site 585395006815 active site 585395006816 Int/Topo IB signature motif; other site 585395006817 Prophage ECO103_P11, lambda-like phage 585395006818 Prophage ECO103_P11; T3SS effector EspV-like protein 585395006819 EspF protein repeat; Region: EspF; pfam04806 585395006820 EspF protein repeat; Region: EspF; pfam04806 585395006821 EspF protein repeat; Region: EspF; pfam04806 585395006822 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395006823 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585395006824 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585395006825 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395006826 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585395006827 Phage-related protein, tail component [Function unknown]; Region: COG4733 585395006828 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585395006829 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585395006830 Interdomain contacts; other site 585395006831 Cytokine receptor motif; other site 585395006832 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585395006833 Fibronectin type III protein; Region: DUF3672; pfam12421 585395006834 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 585395006835 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 585395006836 E-class dimer interface [polypeptide binding]; other site 585395006837 P-class dimer interface [polypeptide binding]; other site 585395006838 active site 585395006839 Cu2+ binding site [ion binding]; other site 585395006840 Zn2+ binding site [ion binding]; other site 585395006841 Phage-related protein, tail component [Function unknown]; Region: COG4723 585395006842 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585395006843 MPN+ (JAMM) motif; other site 585395006844 Zinc-binding site [ion binding]; other site 585395006845 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585395006846 NlpC/P60 family; Region: NLPC_P60; cl17555 585395006847 Phage-related protein [Function unknown]; Region: gp18; COG4672 585395006848 Phage-related protein [Function unknown]; Region: COG4718 585395006849 Phage-related minor tail protein [Function unknown]; Region: COG5281 585395006850 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585395006851 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585395006852 Minor tail protein T; Region: Phage_tail_T; cl05636 585395006853 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 585395006854 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585395006855 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585395006856 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585395006857 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585395006858 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 585395006859 DNA packaging protein FI; Region: Packaging_FI; pfam14000 585395006860 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585395006861 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585395006862 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 585395006863 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 585395006864 tandem repeat interface [polypeptide binding]; other site 585395006865 oligomer interface [polypeptide binding]; other site 585395006866 active site residues [active] 585395006867 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585395006868 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585395006869 gpW; Region: gpW; pfam02831 585395006870 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585395006871 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 585395006872 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 585395006873 PerC transcriptional activator; Region: PerC; pfam06069 585395006874 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585395006875 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585395006876 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585395006877 catalytic residues [active] 585395006878 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 585395006879 Lysis protein S; Region: Lysis_S; pfam04971 585395006880 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585395006881 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585395006882 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 585395006883 tellurite resistance protein terB; Region: terB; cd07176 585395006884 putative metal binding site [ion binding]; other site 585395006885 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585395006886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395006887 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 585395006888 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585395006889 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585395006890 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 585395006891 Hok/gef family; Region: HOK_GEF; pfam01848 585395006892 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585395006893 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 585395006894 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1710 585395006895 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 585395006896 putative replication protein; Provisional; Region: PRK12377 585395006897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395006898 Walker A motif; other site 585395006899 ATP binding site [chemical binding]; other site 585395006900 Walker B motif; other site 585395006901 arginine finger; other site 585395006902 primosomal protein DnaI; Provisional; Region: PRK02854 585395006903 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585395006904 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 585395006905 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585395006906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395006907 sequence-specific DNA binding site [nucleotide binding]; other site 585395006908 salt bridge; other site 585395006909 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585395006910 Catalytic site [active] 585395006911 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 585395006912 putative transposase OrfB; Reviewed; Region: PHA02517 585395006913 HTH-like domain; Region: HTH_21; pfam13276 585395006914 Integrase core domain; Region: rve; pfam00665 585395006915 Integrase core domain; Region: rve_3; pfam13683 585395006916 Transposase; Region: HTH_Tnp_1; cl17663 585395006917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395006918 Prophage ECO103_P11; conserved predicted protein, C-terminal part 585395006919 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 585395006920 active site 585395006921 substrate binding site [chemical binding]; other site 585395006922 catalytic site [active] 585395006923 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 585395006924 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585395006925 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585395006926 active site 585395006927 DNA binding site [nucleotide binding] 585395006928 Int/Topo IB signature motif; other site 585395006929 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 585395006930 predicted adhesin, partial 585395006931 putative transposase OrfB; Reviewed; Region: PHA02517 585395006932 HTH-like domain; Region: HTH_21; pfam13276 585395006933 Integrase core domain; Region: rve; pfam00665 585395006934 Integrase core domain; Region: rve_3; pfam13683 585395006935 Transposase; Region: HTH_Tnp_1; cl17663 585395006936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395006937 predicted adhesin, C-terminal part 585395006938 Transposase; Region: HTH_Tnp_1; cl17663 585395006939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395006940 putative transposase OrfB; Reviewed; Region: PHA02517 585395006941 HTH-like domain; Region: HTH_21; pfam13276 585395006942 Integrase core domain; Region: rve; pfam00665 585395006943 Integrase core domain; Region: rve_3; pfam13683 585395006944 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585395006945 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585395006946 shikimate transporter; Provisional; Region: PRK09952 585395006947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395006948 putative substrate translocation pore; other site 585395006949 AMP nucleosidase; Provisional; Region: PRK08292 585395006950 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 585395006951 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 585395006952 hypothetical protein; Provisional; Region: PRK12378 585395006953 MATE family multidrug exporter; Provisional; Region: PRK10189 585395006954 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 585395006955 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 585395006956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395006957 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 585395006958 putative substrate binding site [chemical binding]; other site 585395006959 dimerization interface [polypeptide binding]; other site 585395006960 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 585395006961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395006962 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 585395006963 putative dimerization interface [polypeptide binding]; other site 585395006964 L,D-transpeptidase; Provisional; Region: PRK10190 585395006965 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585395006966 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 585395006967 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 585395006968 putative dimer interface [polypeptide binding]; other site 585395006969 active site pocket [active] 585395006970 putative cataytic base [active] 585395006971 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 585395006972 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 585395006973 homotrimer interface [polypeptide binding]; other site 585395006974 Walker A motif; other site 585395006975 GTP binding site [chemical binding]; other site 585395006976 Walker B motif; other site 585395006977 outer membrane receptor protein, N-terminal part 585395006978 predicted transpsase of insertion sequence IS682, fragment 585395006979 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585395006980 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 585395006981 substrate binding site [chemical binding]; other site 585395006982 dimer interface [polypeptide binding]; other site 585395006983 ATP binding site [chemical binding]; other site 585395006984 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 585395006985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 585395006986 Protein of unknown function, DUF606; Region: DUF606; pfam04657 585395006987 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 585395006988 active site 585395006989 substrate binding pocket [chemical binding]; other site 585395006990 homodimer interaction site [polypeptide binding]; other site 585395006991 IS unit and the function is not identified, predicted transposase, partial 585395006992 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585395006993 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585395006994 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585395006995 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 585395006996 conserved predicted protein, N-terminal part 585395006997 predicted GTP-binding protein, N-terminal part 585395006998 hypothetical protein; Provisional; Region: PRK09866 585395006999 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585395007000 G1 box; other site 585395007001 GTP/Mg2+ binding site [chemical binding]; other site 585395007002 G2 box; other site 585395007003 Switch I region; other site 585395007004 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585395007005 G3 box; other site 585395007006 Switch II region; other site 585395007007 GTP/Mg2+ binding site [chemical binding]; other site 585395007008 G4 box; other site 585395007009 G5 box; other site 585395007010 YjcZ-like protein; Region: YjcZ; pfam13990 585395007011 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 585395007012 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 585395007013 nucleophile elbow; other site 585395007014 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 585395007015 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585395007016 Antirestriction protein; Region: Antirestrict; pfam03230 585395007017 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585395007018 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585395007019 MPN+ (JAMM) motif; other site 585395007020 Zinc-binding site [ion binding]; other site 585395007021 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585395007022 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585395007023 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 585395007024 conserved predicted protein (pseudogene by IS insertion) 585395007025 hypothetical protein; Provisional; Region: PRK05423 585395007026 Predicted membrane protein [Function unknown]; Region: COG1289 585395007027 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585395007028 DNA gyrase inhibitor; Provisional; Region: PRK10016 585395007029 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 585395007030 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585395007031 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 585395007032 exonuclease I; Provisional; Region: sbcB; PRK11779 585395007033 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 585395007034 active site 585395007035 catalytic site [active] 585395007036 substrate binding site [chemical binding]; other site 585395007037 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 585395007038 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 585395007039 CPxP motif; other site 585395007040 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 585395007041 Sulphur transport; Region: Sulf_transp; pfam04143 585395007042 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 585395007043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395007044 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585395007045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585395007046 dimerization interface [polypeptide binding]; other site 585395007047 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585395007048 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 585395007049 putative NAD(P) binding site [chemical binding]; other site 585395007050 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 585395007051 antitoxin YefM; Provisional; Region: PRK11409 585395007052 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 585395007053 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 585395007054 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 585395007055 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 585395007056 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 585395007057 NAD binding site [chemical binding]; other site 585395007058 dimerization interface [polypeptide binding]; other site 585395007059 product binding site; other site 585395007060 substrate binding site [chemical binding]; other site 585395007061 zinc binding site [ion binding]; other site 585395007062 catalytic residues [active] 585395007063 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 585395007064 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585395007065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395007066 homodimer interface [polypeptide binding]; other site 585395007067 catalytic residue [active] 585395007068 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 585395007069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395007070 active site 585395007071 motif I; other site 585395007072 motif II; other site 585395007073 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 585395007074 putative active site pocket [active] 585395007075 4-fold oligomerization interface [polypeptide binding]; other site 585395007076 metal binding residues [ion binding]; metal-binding site 585395007077 3-fold/trimer interface [polypeptide binding]; other site 585395007078 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 585395007079 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 585395007080 putative active site [active] 585395007081 oxyanion strand; other site 585395007082 catalytic triad [active] 585395007083 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 585395007084 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 585395007085 catalytic residues [active] 585395007086 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 585395007087 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 585395007088 substrate binding site [chemical binding]; other site 585395007089 glutamase interaction surface [polypeptide binding]; other site 585395007090 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 585395007091 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 585395007092 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 585395007093 metal binding site [ion binding]; metal-binding site 585395007094 chain length determinant protein WzzB; Provisional; Region: PRK15471 585395007095 Chain length determinant protein; Region: Wzz; pfam02706 585395007096 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 585395007097 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 585395007098 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 585395007099 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 585395007100 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585395007101 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 585395007102 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 585395007103 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 585395007104 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 585395007105 NAD binding site [chemical binding]; other site 585395007106 homodimer interface [polypeptide binding]; other site 585395007107 active site 585395007108 substrate binding site [chemical binding]; other site 585395007109 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585395007110 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 585395007111 putative ADP-binding pocket [chemical binding]; other site 585395007112 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585395007113 This family is most closely related to the GT1 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor...; Region: GT1_WbdM_like; cd04951 585395007114 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 585395007115 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 585395007116 active site 585395007117 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 585395007118 active site 585395007119 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 585395007120 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 585395007121 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 585395007122 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 585395007123 inhibitor-cofactor binding pocket; inhibition site 585395007124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395007125 catalytic residue [active] 585395007126 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 585395007127 Immunoglobulin domain; Region: Ig; cl11960 585395007128 WxcM-like, C-terminal; Region: FdtA; pfam05523 585395007129 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 585395007130 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 585395007131 substrate binding site; other site 585395007132 tetramer interface; other site 585395007133 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 585395007134 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 585395007135 NAD binding site [chemical binding]; other site 585395007136 substrate binding site [chemical binding]; other site 585395007137 homodimer interface [polypeptide binding]; other site 585395007138 active site 585395007139 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 585395007140 active site 585395007141 tetramer interface; other site 585395007142 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 585395007143 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 585395007144 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 585395007145 putative ADP-binding pocket [chemical binding]; other site 585395007146 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 585395007147 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 585395007148 colanic acid exporter; Provisional; Region: PRK10459 585395007149 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 585395007150 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 585395007151 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 585395007152 phosphomannomutase CpsG; Provisional; Region: PRK15414 585395007153 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 585395007154 active site 585395007155 substrate binding site [chemical binding]; other site 585395007156 metal binding site [ion binding]; metal-binding site 585395007157 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 585395007158 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 585395007159 Substrate binding site; other site 585395007160 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 585395007161 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 585395007162 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 585395007163 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 585395007164 active site 585395007165 GDP-Mannose binding site [chemical binding]; other site 585395007166 dimer interface [polypeptide binding]; other site 585395007167 modified nudix motif 585395007168 metal binding site [ion binding]; metal-binding site 585395007169 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 585395007170 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 585395007171 NADP binding site [chemical binding]; other site 585395007172 active site 585395007173 putative substrate binding site [chemical binding]; other site 585395007174 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 585395007175 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 585395007176 NADP-binding site; other site 585395007177 homotetramer interface [polypeptide binding]; other site 585395007178 substrate binding site [chemical binding]; other site 585395007179 homodimer interface [polypeptide binding]; other site 585395007180 active site 585395007181 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 585395007182 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 585395007183 putative trimer interface [polypeptide binding]; other site 585395007184 putative active site [active] 585395007185 putative substrate binding site [chemical binding]; other site 585395007186 putative CoA binding site [chemical binding]; other site 585395007187 putative glycosyl transferase; Provisional; Region: PRK10063 585395007188 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 585395007189 metal-binding site 585395007190 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 585395007191 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585395007192 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 585395007193 putative acyl transferase; Provisional; Region: PRK10191 585395007194 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585395007195 trimer interface [polypeptide binding]; other site 585395007196 active site 585395007197 substrate binding site [chemical binding]; other site 585395007198 CoA binding site [chemical binding]; other site 585395007199 putative glycosyl transferase; Provisional; Region: PRK10018 585395007200 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 585395007201 active site 585395007202 tyrosine kinase; Provisional; Region: PRK11519 585395007203 Chain length determinant protein; Region: Wzz; pfam02706 585395007204 Chain length determinant protein; Region: Wzz; cl15801 585395007205 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585395007206 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585395007207 Low molecular weight phosphatase family; Region: LMWPc; cd00115 585395007208 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 585395007209 active site 585395007210 polysaccharide export protein Wza; Provisional; Region: PRK15078 585395007211 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 585395007212 SLBB domain; Region: SLBB; pfam10531 585395007213 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585395007214 FOG: CBS domain [General function prediction only]; Region: COG0517 585395007215 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585395007216 Transporter associated domain; Region: CorC_HlyC; smart01091 585395007217 putative assembly protein; Provisional; Region: PRK10833 585395007218 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585395007219 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 585395007220 trimer interface [polypeptide binding]; other site 585395007221 active site 585395007222 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 585395007223 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 585395007224 ATP-binding site [chemical binding]; other site 585395007225 Sugar specificity; other site 585395007226 Pyrimidine base specificity; other site 585395007227 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 585395007228 putative diguanylate cyclase; Provisional; Region: PRK09776 585395007229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585395007230 putative active site [active] 585395007231 heme pocket [chemical binding]; other site 585395007232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585395007233 putative active site [active] 585395007234 heme pocket [chemical binding]; other site 585395007235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585395007236 putative active site [active] 585395007237 heme pocket [chemical binding]; other site 585395007238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395007239 metal binding site [ion binding]; metal-binding site 585395007240 active site 585395007241 I-site; other site 585395007242 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395007243 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 585395007244 AlkA N-terminal domain; Region: AlkA_N; smart01009 585395007245 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585395007246 minor groove reading motif; other site 585395007247 helix-hairpin-helix signature motif; other site 585395007248 substrate binding pocket [chemical binding]; other site 585395007249 active site 585395007250 putative chaperone; Provisional; Region: PRK11678 585395007251 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 585395007252 nucleotide binding site [chemical binding]; other site 585395007253 putative NEF/HSP70 interaction site [polypeptide binding]; other site 585395007254 SBD interface [polypeptide binding]; other site 585395007255 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 585395007256 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 585395007257 substrate binding site [chemical binding]; other site 585395007258 activation loop (A-loop); other site 585395007259 Y-family of DNA polymerases; Region: PolY; cl12025 585395007260 Protein phosphatase 2C; Region: PP2C_2; pfam13672 585395007261 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 585395007262 metal ion-dependent adhesion site (MIDAS); other site 585395007263 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 585395007264 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395007265 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395007266 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 585395007267 Protein export membrane protein; Region: SecD_SecF; cl14618 585395007268 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 585395007269 putative transporter; Provisional; Region: PRK10504 585395007270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395007271 putative substrate translocation pore; other site 585395007272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395007273 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 585395007274 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585395007275 dimerization interface [polypeptide binding]; other site 585395007276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395007277 dimer interface [polypeptide binding]; other site 585395007278 phosphorylation site [posttranslational modification] 585395007279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395007280 ATP binding site [chemical binding]; other site 585395007281 Mg2+ binding site [ion binding]; other site 585395007282 G-X-G motif; other site 585395007283 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 585395007284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395007285 active site 585395007286 phosphorylation site [posttranslational modification] 585395007287 intermolecular recognition site; other site 585395007288 dimerization interface [polypeptide binding]; other site 585395007289 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395007290 DNA binding site [nucleotide binding] 585395007291 Uncharacterized conserved protein [Function unknown]; Region: COG3422 585395007292 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 585395007293 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 585395007294 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 585395007295 putative protease; Provisional; Region: PRK15452 585395007296 Peptidase family U32; Region: Peptidase_U32; pfam01136 585395007297 lipid kinase; Reviewed; Region: PRK13054 585395007298 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 585395007299 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585395007300 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585395007301 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585395007302 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 585395007303 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 585395007304 putative NAD(P) binding site [chemical binding]; other site 585395007305 catalytic Zn binding site [ion binding]; other site 585395007306 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 585395007307 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 585395007308 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 585395007309 active site 585395007310 P-loop; other site 585395007311 phosphorylation site [posttranslational modification] 585395007312 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585395007313 active site 585395007314 phosphorylation site [posttranslational modification] 585395007315 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 585395007316 D-tagatose 1,6-bisphosphate aldolase 2, catalytic subunit GatY, N-terminal deleted by IS insertion 585395007317 putative transposase OrfB; Reviewed; Region: PHA02517 585395007318 HTH-like domain; Region: HTH_21; pfam13276 585395007319 Integrase core domain; Region: rve; pfam00665 585395007320 Integrase core domain; Region: rve_3; pfam13683 585395007321 Transposase; Region: HTH_Tnp_1; cl17663 585395007322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395007323 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 585395007324 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 585395007325 putative active site; other site 585395007326 catalytic residue [active] 585395007327 nucleoside transporter; Region: 2A0110; TIGR00889 585395007328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395007329 putative substrate translocation pore; other site 585395007330 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 585395007331 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585395007332 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 585395007333 substrate binding site [chemical binding]; other site 585395007334 ATP binding site [chemical binding]; other site 585395007335 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585395007336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395007337 DNA-binding site [nucleotide binding]; DNA binding site 585395007338 UTRA domain; Region: UTRA; pfam07702 585395007339 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 585395007340 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 585395007341 active site 585395007342 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 585395007343 dimer interface [polypeptide binding]; other site 585395007344 substrate binding site [chemical binding]; other site 585395007345 ATP binding site [chemical binding]; other site 585395007346 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 585395007347 substrate binding site [chemical binding]; other site 585395007348 multimerization interface [polypeptide binding]; other site 585395007349 ATP binding site [chemical binding]; other site 585395007350 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 585395007351 putative metal binding site [ion binding]; other site 585395007352 putative homodimer interface [polypeptide binding]; other site 585395007353 putative homotetramer interface [polypeptide binding]; other site 585395007354 putative homodimer-homodimer interface [polypeptide binding]; other site 585395007355 putative allosteric switch controlling residues; other site 585395007356 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 585395007357 Predicted integral membrane protein [Function unknown]; Region: COG5455 585395007358 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 585395007359 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 585395007360 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 585395007361 PapC N-terminal domain; Region: PapC_N; pfam13954 585395007362 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585395007363 PapC C-terminal domain; Region: PapC_C; pfam13953 585395007364 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 585395007365 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585395007366 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585395007367 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585395007368 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 585395007369 antiporter inner membrane protein; Provisional; Region: PRK11670 585395007370 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 585395007371 Walker A motif; other site 585395007372 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 585395007373 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 585395007374 active site 585395007375 HIGH motif; other site 585395007376 KMSKS motif; other site 585395007377 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 585395007378 tRNA binding surface [nucleotide binding]; other site 585395007379 anticodon binding site; other site 585395007380 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 585395007381 dimer interface [polypeptide binding]; other site 585395007382 putative tRNA-binding site [nucleotide binding]; other site 585395007383 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 585395007384 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 585395007385 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 585395007386 MoxR-like ATPases [General function prediction only]; Region: COG0714 585395007387 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 585395007388 Walker A motif; other site 585395007389 ATP binding site [chemical binding]; other site 585395007390 Walker B motif; other site 585395007391 arginine finger; other site 585395007392 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 585395007393 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 585395007394 metal ion-dependent adhesion site (MIDAS); other site 585395007395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 585395007396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 585395007397 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 585395007398 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 585395007399 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 585395007400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395007401 active site 585395007402 phosphorylation site [posttranslational modification] 585395007403 intermolecular recognition site; other site 585395007404 dimerization interface [polypeptide binding]; other site 585395007405 LytTr DNA-binding domain; Region: LytTR; pfam04397 585395007406 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 585395007407 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 585395007408 GAF domain; Region: GAF; pfam01590 585395007409 Histidine kinase; Region: His_kinase; pfam06580 585395007410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395007411 ATP binding site [chemical binding]; other site 585395007412 Mg2+ binding site [ion binding]; other site 585395007413 G-X-G motif; other site 585395007414 transcriptional regulator MirA; Provisional; Region: PRK15043 585395007415 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 585395007416 DNA binding residues [nucleotide binding] 585395007417 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 585395007418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395007419 dimer interface [polypeptide binding]; other site 585395007420 conserved gate region; other site 585395007421 putative PBP binding loops; other site 585395007422 ABC-ATPase subunit interface; other site 585395007423 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 585395007424 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 585395007425 Walker A/P-loop; other site 585395007426 ATP binding site [chemical binding]; other site 585395007427 Q-loop/lid; other site 585395007428 ABC transporter signature motif; other site 585395007429 Walker B; other site 585395007430 D-loop; other site 585395007431 H-loop/switch region; other site 585395007432 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 585395007433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395007434 dimer interface [polypeptide binding]; other site 585395007435 conserved gate region; other site 585395007436 ABC-ATPase subunit interface; other site 585395007437 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 585395007438 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 585395007439 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 585395007440 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 585395007441 D-lactate dehydrogenase; Provisional; Region: PRK11183 585395007442 FAD binding domain; Region: FAD_binding_4; pfam01565 585395007443 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 585395007444 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 585395007445 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 585395007446 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 585395007447 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585395007448 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585395007449 oxidoreductase; Provisional; Region: PRK12743 585395007450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585395007451 NAD(P) binding site [chemical binding]; other site 585395007452 active site 585395007453 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 585395007454 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 585395007455 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585395007456 FMN binding site [chemical binding]; other site 585395007457 active site 585395007458 catalytic residues [active] 585395007459 substrate binding site [chemical binding]; other site 585395007460 hypothetical protein; Provisional; Region: PRK01821 585395007461 hypothetical protein; Provisional; Region: PRK10711 585395007462 cytidine deaminase; Provisional; Region: PRK09027 585395007463 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 585395007464 active site 585395007465 catalytic motif [active] 585395007466 Zn binding site [ion binding]; other site 585395007467 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 585395007468 active site 585395007469 catalytic motif [active] 585395007470 Zn binding site [ion binding]; other site 585395007471 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585395007472 putative active site [active] 585395007473 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 585395007474 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 585395007475 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585395007476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395007477 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 585395007478 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 585395007479 homodimer interface [polypeptide binding]; other site 585395007480 active site 585395007481 FMN binding site [chemical binding]; other site 585395007482 substrate binding site [chemical binding]; other site 585395007483 4Fe-4S binding domain; Region: Fer4; pfam00037 585395007484 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585395007485 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585395007486 TM-ABC transporter signature motif; other site 585395007487 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585395007488 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 585395007489 Walker A/P-loop; other site 585395007490 ATP binding site [chemical binding]; other site 585395007491 Q-loop/lid; other site 585395007492 ABC transporter signature motif; other site 585395007493 Walker B; other site 585395007494 D-loop; other site 585395007495 H-loop/switch region; other site 585395007496 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585395007497 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 585395007498 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 585395007499 ligand binding site [chemical binding]; other site 585395007500 calcium binding site [ion binding]; other site 585395007501 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 585395007502 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585395007503 DNA binding site [nucleotide binding] 585395007504 domain linker motif; other site 585395007505 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585395007506 dimerization interface (closed form) [polypeptide binding]; other site 585395007507 ligand binding site [chemical binding]; other site 585395007508 Predicted membrane protein [Function unknown]; Region: COG2311 585395007509 hypothetical protein; Provisional; Region: PRK10835 585395007510 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 585395007511 homodecamer interface [polypeptide binding]; other site 585395007512 GTP cyclohydrolase I; Provisional; Region: PLN03044 585395007513 active site 585395007514 putative catalytic site residues [active] 585395007515 zinc binding site [ion binding]; other site 585395007516 GTP-CH-I/GFRP interaction surface; other site 585395007517 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 585395007518 S-formylglutathione hydrolase; Region: PLN02442 585395007519 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 585395007520 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585395007521 N-terminal plug; other site 585395007522 ligand-binding site [chemical binding]; other site 585395007523 lysine transporter; Provisional; Region: PRK10836 585395007524 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 585395007525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395007526 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 585395007527 putative dimerization interface [polypeptide binding]; other site 585395007528 conserved hypothetical integral membrane protein; Region: TIGR00698 585395007529 endonuclease IV; Provisional; Region: PRK01060 585395007530 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585395007531 AP (apurinic/apyrimidinic) site pocket; other site 585395007532 DNA interaction; other site 585395007533 Metal-binding active site; metal-binding site 585395007534 putative kinase; Provisional; Region: PRK09954 585395007535 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585395007536 putative DNA binding site [nucleotide binding]; other site 585395007537 putative Zn2+ binding site [ion binding]; other site 585395007538 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 585395007539 substrate binding site [chemical binding]; other site 585395007540 ATP binding site [chemical binding]; other site 585395007541 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 585395007542 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 585395007543 Nucleoside recognition; Region: Gate; pfam07670 585395007544 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 585395007545 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585395007546 active site 585395007547 tetramer interface [polypeptide binding]; other site 585395007548 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 585395007549 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585395007550 ligand binding site [chemical binding]; other site 585395007551 flexible hinge region; other site 585395007552 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 585395007553 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 585395007554 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 585395007555 Nucleoside recognition; Region: Gate; pfam07670 585395007556 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 585395007557 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 585395007558 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 585395007559 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585395007560 substrate binding site [chemical binding]; other site 585395007561 ATP binding site [chemical binding]; other site 585395007562 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 585395007563 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 585395007564 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585395007565 active site 585395007566 P-loop; other site 585395007567 phosphorylation site [posttranslational modification] 585395007568 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 585395007569 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 585395007570 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 585395007571 putative substrate binding site [chemical binding]; other site 585395007572 putative ATP binding site [chemical binding]; other site 585395007573 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 585395007574 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585395007575 active site 585395007576 phosphorylation site [posttranslational modification] 585395007577 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585395007578 dimerization domain swap beta strand [polypeptide binding]; other site 585395007579 regulatory protein interface [polypeptide binding]; other site 585395007580 active site 585395007581 regulatory phosphorylation site [posttranslational modification]; other site 585395007582 sugar efflux transporter B; Provisional; Region: PRK15011 585395007583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395007584 putative substrate translocation pore; other site 585395007585 Flagellin N-methylase; Region: FliB; pfam03692 585395007586 elongation factor P; Provisional; Region: PRK04542 585395007587 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 585395007588 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 585395007589 RNA binding site [nucleotide binding]; other site 585395007590 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 585395007591 RNA binding site [nucleotide binding]; other site 585395007592 predicted dehydrogenase, NAD-dependent, C-terminal fragment 585395007593 predicted dehydrogenase, NAD-dependent, C-terminal fragment 585395007594 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 585395007595 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 585395007596 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 585395007597 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585395007598 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 585395007599 active site 585395007600 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 585395007601 NlpC/P60 family; Region: NLPC_P60; pfam00877 585395007602 phage resistance protein; Provisional; Region: PRK10551 585395007603 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585395007604 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395007605 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 585395007606 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 585395007607 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 585395007608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395007609 dimer interface [polypeptide binding]; other site 585395007610 conserved gate region; other site 585395007611 putative PBP binding loops; other site 585395007612 ABC-ATPase subunit interface; other site 585395007613 microcin C ABC transporter permease; Provisional; Region: PRK15021 585395007614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395007615 dimer interface [polypeptide binding]; other site 585395007616 conserved gate region; other site 585395007617 ABC-ATPase subunit interface; other site 585395007618 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 585395007619 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395007620 Walker A/P-loop; other site 585395007621 ATP binding site [chemical binding]; other site 585395007622 Q-loop/lid; other site 585395007623 ABC transporter signature motif; other site 585395007624 Walker B; other site 585395007625 D-loop; other site 585395007626 H-loop/switch region; other site 585395007627 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585395007628 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395007629 Walker A/P-loop; other site 585395007630 ATP binding site [chemical binding]; other site 585395007631 Q-loop/lid; other site 585395007632 ABC transporter signature motif; other site 585395007633 Walker B; other site 585395007634 D-loop; other site 585395007635 H-loop/switch region; other site 585395007636 hypothetical protein; Provisional; Region: PRK11835 585395007637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395007638 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 585395007639 putative substrate translocation pore; other site 585395007640 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 585395007641 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585395007642 RNA binding surface [nucleotide binding]; other site 585395007643 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 585395007644 active site 585395007645 uracil binding [chemical binding]; other site 585395007646 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 585395007647 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395007648 ATP binding site [chemical binding]; other site 585395007649 putative Mg++ binding site [ion binding]; other site 585395007650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395007651 nucleotide binding region [chemical binding]; other site 585395007652 ATP-binding site [chemical binding]; other site 585395007653 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 585395007654 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 585395007655 5S rRNA interface [nucleotide binding]; other site 585395007656 CTC domain interface [polypeptide binding]; other site 585395007657 L16 interface [polypeptide binding]; other site 585395007658 Nucleoid-associated protein [General function prediction only]; Region: COG3081 585395007659 nucleoid-associated protein NdpA; Validated; Region: PRK00378 585395007660 hypothetical protein; Provisional; Region: PRK13689 585395007661 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 585395007662 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 585395007663 Sulfatase; Region: Sulfatase; pfam00884 585395007664 predicted autotransporter outer membrane protein, N-terminal fragment 585395007665 predicted autotransporter outer membrane protein, C-terminal fragment 585395007666 transcriptional regulator NarP; Provisional; Region: PRK10403 585395007667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395007668 active site 585395007669 phosphorylation site [posttranslational modification] 585395007670 intermolecular recognition site; other site 585395007671 dimerization interface [polypeptide binding]; other site 585395007672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395007673 DNA binding residues [nucleotide binding] 585395007674 dimerization interface [polypeptide binding]; other site 585395007675 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 585395007676 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 585395007677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585395007678 binding surface 585395007679 TPR motif; other site 585395007680 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 585395007681 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 585395007682 catalytic residues [active] 585395007683 central insert; other site 585395007684 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 585395007685 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 585395007686 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 585395007687 heme exporter protein CcmC; Region: ccmC; TIGR01191 585395007688 heme exporter protein CcmB; Region: ccmB; TIGR01190 585395007689 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 585395007690 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 585395007691 Walker A/P-loop; other site 585395007692 ATP binding site [chemical binding]; other site 585395007693 Q-loop/lid; other site 585395007694 ABC transporter signature motif; other site 585395007695 Walker B; other site 585395007696 D-loop; other site 585395007697 H-loop/switch region; other site 585395007698 cytochrome c-type protein NapC; Provisional; Region: PRK10617 585395007699 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 585395007700 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 585395007701 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 585395007702 4Fe-4S binding domain; Region: Fer4_5; pfam12801 585395007703 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585395007704 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 585395007705 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 585395007706 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 585395007707 [4Fe-4S] binding site [ion binding]; other site 585395007708 molybdopterin cofactor binding site; other site 585395007709 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 585395007710 molybdopterin cofactor binding site; other site 585395007711 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 585395007712 ferredoxin-type protein; Provisional; Region: PRK10194 585395007713 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 585395007714 secondary substrate binding site; other site 585395007715 primary substrate binding site; other site 585395007716 inhibition loop; other site 585395007717 dimerization interface [polypeptide binding]; other site 585395007718 malate:quinone oxidoreductase; Validated; Region: PRK05257 585395007719 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 585395007720 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 585395007721 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 585395007722 Walker A/P-loop; other site 585395007723 ATP binding site [chemical binding]; other site 585395007724 Q-loop/lid; other site 585395007725 ABC transporter signature motif; other site 585395007726 Walker B; other site 585395007727 D-loop; other site 585395007728 H-loop/switch region; other site 585395007729 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 585395007730 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 585395007731 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 585395007732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395007733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395007734 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 585395007735 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585395007736 DNA binding site [nucleotide binding] 585395007737 active site 585395007738 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 585395007739 ApbE family; Region: ApbE; pfam02424 585395007740 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585395007741 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585395007742 trimer interface [polypeptide binding]; other site 585395007743 eyelet of channel; other site 585395007744 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 585395007745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395007746 ATP binding site [chemical binding]; other site 585395007747 G-X-G motif; other site 585395007748 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585395007749 putative binding surface; other site 585395007750 active site 585395007751 transcriptional regulator RcsB; Provisional; Region: PRK10840 585395007752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395007753 active site 585395007754 phosphorylation site [posttranslational modification] 585395007755 intermolecular recognition site; other site 585395007756 dimerization interface [polypeptide binding]; other site 585395007757 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395007758 DNA binding residues [nucleotide binding] 585395007759 dimerization interface [polypeptide binding]; other site 585395007760 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 585395007761 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395007762 dimer interface [polypeptide binding]; other site 585395007763 phosphorylation site [posttranslational modification] 585395007764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395007765 ATP binding site [chemical binding]; other site 585395007766 Mg2+ binding site [ion binding]; other site 585395007767 G-X-G motif; other site 585395007768 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 585395007769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395007770 active site 585395007771 phosphorylation site [posttranslational modification] 585395007772 intermolecular recognition site; other site 585395007773 dimerization interface [polypeptide binding]; other site 585395007774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 585395007775 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 585395007776 Predicted secreted protein [Function unknown]; Region: COG5445 585395007777 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 585395007778 Predicted secreted protein [Function unknown]; Region: COG5445 585395007779 Stage II sporulation protein; Region: SpoIID; pfam08486 585395007780 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 585395007781 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 585395007782 MG2 domain; Region: A2M_N; pfam01835 585395007783 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 585395007784 Alpha-2-macroglobulin family; Region: A2M; pfam00207 585395007785 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 585395007786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 585395007787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 585395007788 DNA gyrase subunit A; Validated; Region: PRK05560 585395007789 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 585395007790 CAP-like domain; other site 585395007791 active site 585395007792 primary dimer interface [polypeptide binding]; other site 585395007793 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585395007794 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585395007795 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585395007796 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585395007797 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585395007798 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585395007799 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 585395007800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395007801 S-adenosylmethionine binding site [chemical binding]; other site 585395007802 adhesin; Provisional; Region: PRK09752 585395007803 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585395007804 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585395007805 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 585395007806 ATP cone domain; Region: ATP-cone; pfam03477 585395007807 Class I ribonucleotide reductase; Region: RNR_I; cd01679 585395007808 active site 585395007809 dimer interface [polypeptide binding]; other site 585395007810 catalytic residues [active] 585395007811 effector binding site; other site 585395007812 R2 peptide binding site; other site 585395007813 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 585395007814 dimer interface [polypeptide binding]; other site 585395007815 putative radical transfer pathway; other site 585395007816 diiron center [ion binding]; other site 585395007817 tyrosyl radical; other site 585395007818 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585395007819 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585395007820 catalytic loop [active] 585395007821 iron binding site [ion binding]; other site 585395007822 hypothetical protein; Provisional; Region: PRK09902 585395007823 hypothetical protein; Provisional; Region: PRK09729 585395007824 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 585395007825 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 585395007826 active site 585395007827 catalytic site [active] 585395007828 metal binding site [ion binding]; metal-binding site 585395007829 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 585395007830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395007831 putative substrate translocation pore; other site 585395007832 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 585395007833 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585395007834 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585395007835 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 585395007836 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 585395007837 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 585395007838 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585395007839 Cysteine-rich domain; Region: CCG; pfam02754 585395007840 Cysteine-rich domain; Region: CCG; pfam02754 585395007841 hypothetical protein; Provisional; Region: PRK09956 585395007842 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585395007843 predicted 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, C-terminal fragment 585395007844 hypothetical protein; Provisional; Region: PRK03673 585395007845 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 585395007846 putative MPT binding site; other site 585395007847 Competence-damaged protein; Region: CinA; cl00666 585395007848 YfaZ precursor; Region: YfaZ; pfam07437 585395007849 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 585395007850 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 585395007851 catalytic core [active] 585395007852 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 585395007853 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 585395007854 inhibitor-cofactor binding pocket; inhibition site 585395007855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395007856 catalytic residue [active] 585395007857 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 585395007858 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 585395007859 Ligand binding site; other site 585395007860 Putative Catalytic site; other site 585395007861 DXD motif; other site 585395007862 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 585395007863 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 585395007864 substrate binding site [chemical binding]; other site 585395007865 cosubstrate binding site; other site 585395007866 catalytic site [active] 585395007867 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 585395007868 active site 585395007869 hexamer interface [polypeptide binding]; other site 585395007870 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 585395007871 NAD binding site [chemical binding]; other site 585395007872 substrate binding site [chemical binding]; other site 585395007873 active site 585395007874 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 585395007875 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 585395007876 putative active site [active] 585395007877 putative catalytic site [active] 585395007878 putative Zn binding site [ion binding]; other site 585395007879 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 585395007880 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 585395007881 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 585395007882 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 585395007883 signal transduction protein PmrD; Provisional; Region: PRK15450 585395007884 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 585395007885 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 585395007886 acyl-activating enzyme (AAE) consensus motif; other site 585395007887 putative AMP binding site [chemical binding]; other site 585395007888 putative active site [active] 585395007889 putative CoA binding site [chemical binding]; other site 585395007890 O-succinylbenzoate synthase; Provisional; Region: PRK05105 585395007891 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 585395007892 active site 585395007893 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585395007894 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 585395007895 substrate binding site [chemical binding]; other site 585395007896 oxyanion hole (OAH) forming residues; other site 585395007897 trimer interface [polypeptide binding]; other site 585395007898 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 585395007899 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 585395007900 catalytic site [active] 585395007901 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 585395007902 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 585395007903 dimer interface [polypeptide binding]; other site 585395007904 tetramer interface [polypeptide binding]; other site 585395007905 PYR/PP interface [polypeptide binding]; other site 585395007906 TPP binding site [chemical binding]; other site 585395007907 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 585395007908 TPP-binding site; other site 585395007909 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 585395007910 isochorismate synthases; Region: isochor_syn; TIGR00543 585395007911 hypothetical protein; Provisional; Region: PRK10404 585395007912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395007913 Coenzyme A binding pocket [chemical binding]; other site 585395007914 ribonuclease BN; Region: true_RNase_BN; TIGR02649 585395007915 predicted enzyme, N-terminal fragment 585395007916 predicted enzyme, C-terminal fragment 585395007917 predicted peptidase, N-terminal part 585395007918 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 585395007919 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 585395007920 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585395007921 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 585395007922 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585395007923 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 585395007924 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 585395007925 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585395007926 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 585395007927 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 585395007928 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 585395007929 4Fe-4S binding domain; Region: Fer4; pfam00037 585395007930 4Fe-4S binding domain; Region: Fer4; pfam00037 585395007931 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 585395007932 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 585395007933 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585395007934 catalytic loop [active] 585395007935 iron binding site [ion binding]; other site 585395007936 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 585395007937 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 585395007938 [4Fe-4S] binding site [ion binding]; other site 585395007939 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 585395007940 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 585395007941 SLBB domain; Region: SLBB; pfam10531 585395007942 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 585395007943 NADH dehydrogenase subunit E; Validated; Region: PRK07539 585395007944 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 585395007945 putative dimer interface [polypeptide binding]; other site 585395007946 [2Fe-2S] cluster binding site [ion binding]; other site 585395007947 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 585395007948 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 585395007949 NADH dehydrogenase subunit D; Validated; Region: PRK06075 585395007950 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 585395007951 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 585395007952 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 585395007953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395007954 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 585395007955 putative dimerization interface [polypeptide binding]; other site 585395007956 aminotransferase AlaT; Validated; Region: PRK09265 585395007957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585395007958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395007959 homodimer interface [polypeptide binding]; other site 585395007960 catalytic residue [active] 585395007961 5'-nucleotidase; Provisional; Region: PRK03826 585395007962 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 585395007963 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585395007964 TrkA-C domain; Region: TrkA_C; pfam02080 585395007965 TrkA-C domain; Region: TrkA_C; pfam02080 585395007966 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 585395007967 putative phosphatase; Provisional; Region: PRK11587 585395007968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395007969 motif II; other site 585395007970 hypothetical protein; Validated; Region: PRK05445 585395007971 hypothetical protein; Provisional; Region: PRK01816 585395007972 propionate/acetate kinase; Provisional; Region: PRK12379 585395007973 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 585395007974 phosphate acetyltransferase; Reviewed; Region: PRK05632 585395007975 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585395007976 DRTGG domain; Region: DRTGG; pfam07085 585395007977 phosphate acetyltransferase; Region: pta; TIGR00651 585395007978 hypothetical protein; Provisional; Region: PRK11588 585395007979 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 585395007980 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 585395007981 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 585395007982 nudix motif; other site 585395007983 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 585395007984 active site 585395007985 metal binding site [ion binding]; metal-binding site 585395007986 homotetramer interface [polypeptide binding]; other site 585395007987 glutathione S-transferase; Provisional; Region: PRK15113 585395007988 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 585395007989 C-terminal domain interface [polypeptide binding]; other site 585395007990 GSH binding site (G-site) [chemical binding]; other site 585395007991 dimer interface [polypeptide binding]; other site 585395007992 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 585395007993 N-terminal domain interface [polypeptide binding]; other site 585395007994 putative dimer interface [polypeptide binding]; other site 585395007995 putative substrate binding pocket (H-site) [chemical binding]; other site 585395007996 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 585395007997 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 585395007998 C-terminal domain interface [polypeptide binding]; other site 585395007999 GSH binding site (G-site) [chemical binding]; other site 585395008000 dimer interface [polypeptide binding]; other site 585395008001 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 585395008002 N-terminal domain interface [polypeptide binding]; other site 585395008003 putative dimer interface [polypeptide binding]; other site 585395008004 active site 585395008005 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 585395008006 homooctamer interface [polypeptide binding]; other site 585395008007 active site 585395008008 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 585395008009 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 585395008010 putative NAD(P) binding site [chemical binding]; other site 585395008011 putative active site [active] 585395008012 putative transposase; Provisional; Region: PRK09857 585395008013 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585395008014 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 585395008015 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585395008016 Walker A/P-loop; other site 585395008017 ATP binding site [chemical binding]; other site 585395008018 Q-loop/lid; other site 585395008019 ABC transporter signature motif; other site 585395008020 Walker B; other site 585395008021 D-loop; other site 585395008022 H-loop/switch region; other site 585395008023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395008024 dimer interface [polypeptide binding]; other site 585395008025 conserved gate region; other site 585395008026 putative PBP binding loops; other site 585395008027 ABC-ATPase subunit interface; other site 585395008028 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585395008029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395008030 dimer interface [polypeptide binding]; other site 585395008031 conserved gate region; other site 585395008032 putative PBP binding loops; other site 585395008033 ABC-ATPase subunit interface; other site 585395008034 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 585395008035 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395008036 substrate binding pocket [chemical binding]; other site 585395008037 membrane-bound complex binding site; other site 585395008038 hinge residues; other site 585395008039 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 585395008040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395008041 substrate binding pocket [chemical binding]; other site 585395008042 membrane-bound complex binding site; other site 585395008043 hinge residues; other site 585395008044 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 585395008045 Flavoprotein; Region: Flavoprotein; pfam02441 585395008046 amidophosphoribosyltransferase; Provisional; Region: PRK09246 585395008047 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 585395008048 active site 585395008049 tetramer interface [polypeptide binding]; other site 585395008050 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585395008051 active site 585395008052 colicin V production protein; Provisional; Region: PRK10845 585395008053 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 585395008054 cell division protein DedD; Provisional; Region: PRK11633 585395008055 Sporulation related domain; Region: SPOR; pfam05036 585395008056 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 585395008057 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585395008058 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585395008059 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 585395008060 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 585395008061 hypothetical protein; Provisional; Region: PRK10847 585395008062 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585395008063 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 585395008064 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 585395008065 dimerization interface 3.5A [polypeptide binding]; other site 585395008066 active site 585395008067 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 585395008068 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585395008069 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 585395008070 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 585395008071 ligand binding site [chemical binding]; other site 585395008072 NAD binding site [chemical binding]; other site 585395008073 catalytic site [active] 585395008074 homodimer interface [polypeptide binding]; other site 585395008075 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 585395008076 putative transporter; Provisional; Region: PRK12382 585395008077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395008078 putative substrate translocation pore; other site 585395008079 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 585395008080 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 585395008081 dimer interface [polypeptide binding]; other site 585395008082 active site 585395008083 Uncharacterized conserved protein [Function unknown]; Region: COG4121 585395008084 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 585395008085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585395008086 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585395008087 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585395008088 YfcL protein; Region: YfcL; pfam08891 585395008089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 585395008090 hypothetical protein; Provisional; Region: PRK10621 585395008091 Predicted permeases [General function prediction only]; Region: COG0730 585395008092 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 585395008093 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 585395008094 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 585395008095 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 585395008096 Tetramer interface [polypeptide binding]; other site 585395008097 active site 585395008098 FMN-binding site [chemical binding]; other site 585395008099 HemK family putative methylases; Region: hemK_fam; TIGR00536 585395008100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395008101 S-adenosylmethionine binding site [chemical binding]; other site 585395008102 hypothetical protein; Provisional; Region: PRK04946 585395008103 Smr domain; Region: Smr; pfam01713 585395008104 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 585395008105 Fimbrial protein; Region: Fimbrial; cl01416 585395008106 Fimbrial protein; Region: Fimbrial; cl01416 585395008107 Fimbrial protein; Region: Fimbrial; cl01416 585395008108 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585395008109 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585395008110 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 585395008111 PapC N-terminal domain; Region: PapC_N; pfam13954 585395008112 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585395008113 PapC C-terminal domain; Region: PapC_C; pfam13953 585395008114 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585395008115 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585395008116 catalytic core [active] 585395008117 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 585395008118 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585395008119 substrate binding site [chemical binding]; other site 585395008120 oxyanion hole (OAH) forming residues; other site 585395008121 trimer interface [polypeptide binding]; other site 585395008122 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585395008123 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585395008124 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 585395008125 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585395008126 dimer interface [polypeptide binding]; other site 585395008127 active site 585395008128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 585395008129 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 585395008130 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 585395008131 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 585395008132 Prophage ECO103_P12, lambda-like phage 585395008133 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585395008134 Phage-related protein, tail component [Function unknown]; Region: COG4733 585395008135 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585395008136 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395008137 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585395008138 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585395008139 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585395008140 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395008141 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 585395008142 large terminase protein; Provisional; Region: 17; PHA02533 585395008143 large terminase protein; Provisional; Region: 17; PHA02533 585395008144 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 585395008145 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 585395008146 ORF11CD3 domain; Region: ORF11CD3; pfam10549 585395008147 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585395008148 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585395008149 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 585395008150 ORF11CD3 domain; Region: ORF11CD3; pfam10549 585395008151 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585395008152 catalytic residues [active] 585395008153 Lysis protein S; Region: Lysis_S; pfam04971 585395008154 Protein of unknown function (DUF826); Region: DUF826; pfam05696 585395008155 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585395008156 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585395008157 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 585395008158 Shiga-like toxin beta subunit; Region: SLT_beta; pfam02258 585395008159 Ribosome inactivating protein; Region: RIP; pfam00161 585395008160 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585395008161 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 585395008162 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 585395008163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 585395008164 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 585395008165 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 585395008166 active site 585395008167 metal binding site [ion binding]; metal-binding site 585395008168 interdomain interaction site; other site 585395008169 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 585395008170 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395008171 ATP binding site [chemical binding]; other site 585395008172 putative Mg++ binding site [ion binding]; other site 585395008173 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395008174 nucleotide binding region [chemical binding]; other site 585395008175 ATP-binding site [chemical binding]; other site 585395008176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395008177 non-specific DNA binding site [nucleotide binding]; other site 585395008178 salt bridge; other site 585395008179 sequence-specific DNA binding site [nucleotide binding]; other site 585395008180 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395008181 non-specific DNA binding site [nucleotide binding]; other site 585395008182 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585395008183 salt bridge; other site 585395008184 sequence-specific DNA binding site [nucleotide binding]; other site 585395008185 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585395008186 Catalytic site [active] 585395008187 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 585395008188 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 585395008189 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 585395008190 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 585395008191 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585395008192 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 585395008193 RecT family; Region: RecT; pfam03837 585395008194 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 585395008195 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 585395008196 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585395008197 Active Sites [active] 585395008198 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585395008199 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585395008200 AntA/AntB antirepressor; Region: AntA; pfam08346 585395008201 Phage anti-repressor protein [Transcription]; Region: COG3561 585395008202 MT-A70; Region: MT-A70; cl01947 585395008203 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 585395008204 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 585395008205 Helix-turn-helix domain; Region: HTH_17; cl17695 585395008206 integrase; Provisional; Region: PRK09692 585395008207 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585395008208 active site 585395008209 Int/Topo IB signature motif; other site 585395008210 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 585395008211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395008212 putative substrate translocation pore; other site 585395008213 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585395008214 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 585395008215 putative substrate binding site [chemical binding]; other site 585395008216 putative ATP binding site [chemical binding]; other site 585395008217 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 585395008218 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 585395008219 substrate binding [chemical binding]; other site 585395008220 active site 585395008221 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 585395008222 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585395008223 DNA binding site [nucleotide binding] 585395008224 domain linker motif; other site 585395008225 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 585395008226 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 585395008227 putative dimerization interface [polypeptide binding]; other site 585395008228 putative ligand binding site [chemical binding]; other site 585395008229 transport protein, C-terminal fragment 585395008230 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 585395008231 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 585395008232 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585395008233 catalytic residue [active] 585395008234 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 585395008235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395008236 putative substrate translocation pore; other site 585395008237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395008238 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 585395008239 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395008240 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395008241 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 585395008242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395008243 active site 585395008244 phosphorylation site [posttranslational modification] 585395008245 intermolecular recognition site; other site 585395008246 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395008247 DNA binding residues [nucleotide binding] 585395008248 dimerization interface [polypeptide binding]; other site 585395008249 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 585395008250 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395008251 substrate binding pocket [chemical binding]; other site 585395008252 membrane-bound complex binding site; other site 585395008253 hinge residues; other site 585395008254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395008255 substrate binding pocket [chemical binding]; other site 585395008256 membrane-bound complex binding site; other site 585395008257 hinge residues; other site 585395008258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395008259 dimer interface [polypeptide binding]; other site 585395008260 phosphorylation site [posttranslational modification] 585395008261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395008262 ATP binding site [chemical binding]; other site 585395008263 Mg2+ binding site [ion binding]; other site 585395008264 G-X-G motif; other site 585395008265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395008266 active site 585395008267 phosphorylation site [posttranslational modification] 585395008268 intermolecular recognition site; other site 585395008269 dimerization interface [polypeptide binding]; other site 585395008270 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585395008271 putative binding surface; other site 585395008272 active site 585395008273 putative CoA-transferase; Provisional; Region: PRK11430 585395008274 CoA-transferase family III; Region: CoA_transf_3; pfam02515 585395008275 putative transporter YfdV; Provisional; Region: PRK09903 585395008276 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 585395008277 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585395008278 PYR/PP interface [polypeptide binding]; other site 585395008279 dimer interface [polypeptide binding]; other site 585395008280 TPP binding site [chemical binding]; other site 585395008281 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585395008282 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 585395008283 TPP-binding site; other site 585395008284 dimer interface [polypeptide binding]; other site 585395008285 formyl-coenzyme A transferase; Provisional; Region: PRK05398 585395008286 CoA-transferase family III; Region: CoA_transf_3; pfam02515 585395008287 hypothetical protein; Provisional; Region: PRK10316 585395008288 YfdX protein; Region: YfdX; pfam10938 585395008289 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 585395008290 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585395008291 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585395008292 putative acyl-acceptor binding pocket; other site 585395008293 aminotransferase; Validated; Region: PRK08175 585395008294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585395008295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395008296 homodimer interface [polypeptide binding]; other site 585395008297 catalytic residue [active] 585395008298 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 585395008299 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 585395008300 GAF domain; Region: GAF; pfam01590 585395008301 Histidine kinase; Region: His_kinase; pfam06580 585395008302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395008303 ATP binding site [chemical binding]; other site 585395008304 Mg2+ binding site [ion binding]; other site 585395008305 G-X-G motif; other site 585395008306 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 585395008307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395008308 active site 585395008309 phosphorylation site [posttranslational modification] 585395008310 intermolecular recognition site; other site 585395008311 dimerization interface [polypeptide binding]; other site 585395008312 LytTr DNA-binding domain; Region: LytTR; pfam04397 585395008313 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585395008314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395008315 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585395008316 dimerization domain swap beta strand [polypeptide binding]; other site 585395008317 regulatory protein interface [polypeptide binding]; other site 585395008318 active site 585395008319 regulatory phosphorylation site [posttranslational modification]; other site 585395008320 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585395008321 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 585395008322 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585395008323 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585395008324 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585395008325 active site 585395008326 phosphorylation site [posttranslational modification] 585395008327 exoaminopeptidase; Provisional; Region: PRK09961 585395008328 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 585395008329 oligomer interface [polypeptide binding]; other site 585395008330 active site 585395008331 metal binding site [ion binding]; metal-binding site 585395008332 aminopeptidase; Provisional; Region: PRK09795 585395008333 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 585395008334 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 585395008335 active site 585395008336 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 585395008337 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585395008338 active site 585395008339 P-loop; other site 585395008340 phosphorylation site [posttranslational modification] 585395008341 glucokinase, proteobacterial type; Region: glk; TIGR00749 585395008342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585395008343 nucleotide binding site [chemical binding]; other site 585395008344 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585395008345 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 585395008346 Cl- selectivity filter; other site 585395008347 Cl- binding residues [ion binding]; other site 585395008348 pore gating glutamate residue; other site 585395008349 dimer interface [polypeptide binding]; other site 585395008350 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 585395008351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585395008352 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585395008353 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585395008354 manganese transport protein MntH; Reviewed; Region: PRK00701 585395008355 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 585395008356 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 585395008357 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 585395008358 Nucleoside recognition; Region: Gate; pfam07670 585395008359 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 585395008360 MASE1; Region: MASE1; pfam05231 585395008361 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585395008362 diguanylate cyclase; Region: GGDEF; smart00267 585395008363 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395008364 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 585395008365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395008366 salt bridge; other site 585395008367 non-specific DNA binding site [nucleotide binding]; other site 585395008368 sequence-specific DNA binding site [nucleotide binding]; other site 585395008369 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 585395008370 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 585395008371 active site 585395008372 HIGH motif; other site 585395008373 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 585395008374 active site 585395008375 KMSKS motif; other site 585395008376 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 585395008377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395008378 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 585395008379 putative dimerization interface [polypeptide binding]; other site 585395008380 putative substrate binding pocket [chemical binding]; other site 585395008381 nucleoside transporter; Region: 2A0110; TIGR00889 585395008382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395008383 putative substrate translocation pore; other site 585395008384 purine nucleoside phosphorylase; Provisional; Region: PRK08202 585395008385 hypothetical protein; Provisional; Region: PRK11528 585395008386 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585395008387 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395008388 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 585395008389 putative dimerization interface [polypeptide binding]; other site 585395008390 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 585395008391 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 585395008392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 585395008393 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 585395008394 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 585395008395 nucleotide binding pocket [chemical binding]; other site 585395008396 K-X-D-G motif; other site 585395008397 catalytic site [active] 585395008398 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 585395008399 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 585395008400 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 585395008401 Dimer interface [polypeptide binding]; other site 585395008402 BRCT sequence motif; other site 585395008403 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 585395008404 cell division protein ZipA; Provisional; Region: PRK03427 585395008405 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 585395008406 FtsZ protein binding site [polypeptide binding]; other site 585395008407 putative sulfate transport protein CysZ; Validated; Region: PRK04949 585395008408 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 585395008409 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 585395008410 dimer interface [polypeptide binding]; other site 585395008411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395008412 catalytic residue [active] 585395008413 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585395008414 dimerization domain swap beta strand [polypeptide binding]; other site 585395008415 regulatory protein interface [polypeptide binding]; other site 585395008416 active site 585395008417 regulatory phosphorylation site [posttranslational modification]; other site 585395008418 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 585395008419 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585395008420 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585395008421 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585395008422 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585395008423 HPr interaction site; other site 585395008424 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585395008425 active site 585395008426 phosphorylation site [posttranslational modification] 585395008427 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 585395008428 dimer interface [polypeptide binding]; other site 585395008429 pyridoxamine kinase; Validated; Region: PRK05756 585395008430 pyridoxal binding site [chemical binding]; other site 585395008431 ATP binding site [chemical binding]; other site 585395008432 hypothetical protein; Provisional; Region: PRK10318 585395008433 cysteine synthase B; Region: cysM; TIGR01138 585395008434 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 585395008435 dimer interface [polypeptide binding]; other site 585395008436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395008437 catalytic residue [active] 585395008438 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 585395008439 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 585395008440 Walker A/P-loop; other site 585395008441 ATP binding site [chemical binding]; other site 585395008442 Q-loop/lid; other site 585395008443 ABC transporter signature motif; other site 585395008444 Walker B; other site 585395008445 D-loop; other site 585395008446 H-loop/switch region; other site 585395008447 TOBE-like domain; Region: TOBE_3; pfam12857 585395008448 sulfate transport protein; Provisional; Region: cysT; CHL00187 585395008449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395008450 dimer interface [polypeptide binding]; other site 585395008451 conserved gate region; other site 585395008452 putative PBP binding loops; other site 585395008453 ABC-ATPase subunit interface; other site 585395008454 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 585395008455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395008456 dimer interface [polypeptide binding]; other site 585395008457 conserved gate region; other site 585395008458 putative PBP binding loops; other site 585395008459 ABC-ATPase subunit interface; other site 585395008460 thiosulfate transporter subunit; Provisional; Region: PRK10852 585395008461 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 585395008462 short chain dehydrogenase; Provisional; Region: PRK08226 585395008463 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 585395008464 NAD binding site [chemical binding]; other site 585395008465 homotetramer interface [polypeptide binding]; other site 585395008466 homodimer interface [polypeptide binding]; other site 585395008467 active site 585395008468 transcriptional regulator MurR; Provisional; Region: PRK15482 585395008469 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585395008470 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585395008471 putative active site [active] 585395008472 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 585395008473 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 585395008474 putative active site [active] 585395008475 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 585395008476 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585395008477 active site turn [active] 585395008478 phosphorylation site [posttranslational modification] 585395008479 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585395008480 putative periplasmic esterase; Provisional; Region: PRK03642 585395008481 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585395008482 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 585395008483 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 585395008484 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 585395008485 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 585395008486 putative acetyltransferase; Provisional; Region: PRK03624 585395008487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395008488 Coenzyme A binding pocket [chemical binding]; other site 585395008489 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 585395008490 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585395008491 active site 585395008492 metal binding site [ion binding]; metal-binding site 585395008493 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 585395008494 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 585395008495 transcriptional regulator EutR; Provisional; Region: PRK10130 585395008496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395008497 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395008498 carboxysome structural protein EutK; Provisional; Region: PRK15466 585395008499 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 585395008500 Hexamer interface [polypeptide binding]; other site 585395008501 Hexagonal pore residue; other site 585395008502 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 585395008503 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 585395008504 putative hexamer interface [polypeptide binding]; other site 585395008505 putative hexagonal pore; other site 585395008506 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 585395008507 putative hexamer interface [polypeptide binding]; other site 585395008508 putative hexagonal pore; other site 585395008509 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 585395008510 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 585395008511 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 585395008512 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 585395008513 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 585395008514 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 585395008515 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 585395008516 active site 585395008517 metal binding site [ion binding]; metal-binding site 585395008518 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 585395008519 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585395008520 nucleotide binding site [chemical binding]; other site 585395008521 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 585395008522 putative catalytic cysteine [active] 585395008523 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 585395008524 Hexamer/Pentamer interface [polypeptide binding]; other site 585395008525 central pore; other site 585395008526 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 585395008527 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 585395008528 Hexamer interface [polypeptide binding]; other site 585395008529 Putative hexagonal pore residue; other site 585395008530 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 585395008531 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 585395008532 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 585395008533 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 585395008534 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 585395008535 G1 box; other site 585395008536 GTP/Mg2+ binding site [chemical binding]; other site 585395008537 G2 box; other site 585395008538 Switch I region; other site 585395008539 G3 box; other site 585395008540 Switch II region; other site 585395008541 G4 box; other site 585395008542 G5 box; other site 585395008543 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 585395008544 putative hexamer interface [polypeptide binding]; other site 585395008545 putative hexagonal pore; other site 585395008546 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 585395008547 Malic enzyme, N-terminal domain; Region: malic; pfam00390 585395008548 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 585395008549 putative NAD(P) binding site [chemical binding]; other site 585395008550 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 585395008551 transaldolase-like protein; Provisional; Region: PTZ00411 585395008552 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 585395008553 active site 585395008554 dimer interface [polypeptide binding]; other site 585395008555 catalytic residue [active] 585395008556 transketolase; Reviewed; Region: PRK12753 585395008557 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 585395008558 TPP-binding site [chemical binding]; other site 585395008559 dimer interface [polypeptide binding]; other site 585395008560 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585395008561 PYR/PP interface [polypeptide binding]; other site 585395008562 dimer interface [polypeptide binding]; other site 585395008563 TPP binding site [chemical binding]; other site 585395008564 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585395008565 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 585395008566 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 585395008567 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585395008568 dimer interface [polypeptide binding]; other site 585395008569 ADP-ribose binding site [chemical binding]; other site 585395008570 active site 585395008571 nudix motif; other site 585395008572 metal binding site [ion binding]; metal-binding site 585395008573 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 585395008574 4Fe-4S binding domain; Region: Fer4; pfam00037 585395008575 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585395008576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395008577 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 585395008578 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 585395008579 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585395008580 dimerization interface [polypeptide binding]; other site 585395008581 Histidine kinase; Region: HisKA_3; pfam07730 585395008582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395008583 ATP binding site [chemical binding]; other site 585395008584 Mg2+ binding site [ion binding]; other site 585395008585 G-X-G motif; other site 585395008586 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 585395008587 Protein export membrane protein; Region: SecD_SecF; cl14618 585395008588 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 585395008589 ArsC family; Region: ArsC; pfam03960 585395008590 putative catalytic residues [active] 585395008591 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 585395008592 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 585395008593 metal binding site [ion binding]; metal-binding site 585395008594 dimer interface [polypeptide binding]; other site 585395008595 hypothetical protein; Provisional; Region: PRK13664 585395008596 putative hydrolase; Provisional; Region: PRK11460 585395008597 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 585395008598 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 585395008599 Helicase; Region: Helicase_RecD; pfam05127 585395008600 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 585395008601 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 585395008602 Predicted metalloprotease [General function prediction only]; Region: COG2321 585395008603 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 585395008604 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 585395008605 oligomeric interface; other site 585395008606 putative active site [active] 585395008607 homodimer interface [polypeptide binding]; other site 585395008608 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 585395008609 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 585395008610 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 585395008611 ATP binding site [chemical binding]; other site 585395008612 active site 585395008613 substrate binding site [chemical binding]; other site 585395008614 lipoprotein; Provisional; Region: PRK11679 585395008615 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 585395008616 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 585395008617 dihydrodipicolinate synthase; Region: dapA; TIGR00674 585395008618 dimer interface [polypeptide binding]; other site 585395008619 active site 585395008620 catalytic residue [active] 585395008621 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 585395008622 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 585395008623 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 585395008624 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 585395008625 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 585395008626 catalytic triad [active] 585395008627 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585395008628 4Fe-4S binding domain; Region: Fer4; pfam00037 585395008629 hydrogenase 4, membrane subunit HyfB, N-terminal fragment 585395008630 hydrogenase 4, membrane subunit HyfB, C-terminal fragment 585395008631 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 585395008632 NADH dehydrogenase; Region: NADHdh; cl00469 585395008633 hydrogenase 4, membrane subunit HyfD, N-terminal part 585395008634 hydrogenase 4, membrane subunit HyfD, middle part 585395008635 hydrogenase 4, membrane subunit HyfD, C-terminal part 585395008636 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 585395008637 hydrogenase 4 subunit F; Validated; Region: PRK06458 585395008638 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585395008639 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 585395008640 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 585395008641 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 585395008642 hydrogenase 4, Fe-S subunit HyfH, N-terminal fragment 585395008643 hydrogenase 4, Fe-S subunit HyfH, C-terminal fragment 585395008644 hydrogenase 4, Fe-S subunit HyfI, N-terminal fragment 585395008645 hydrogenase 4, Fe-S subunit HyfI, C-terminal fragment 585395008646 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 585395008647 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 585395008648 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585395008649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395008650 Walker A motif; other site 585395008651 ATP binding site [chemical binding]; other site 585395008652 Walker B motif; other site 585395008653 arginine finger; other site 585395008654 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585395008655 putative formate transporter; Provisional; Region: focB; PRK09713 585395008656 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 585395008657 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585395008658 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 585395008659 Peptidase family M48; Region: Peptidase_M48; cl12018 585395008660 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 585395008661 ArsC family; Region: ArsC; pfam03960 585395008662 catalytic residues [active] 585395008663 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 585395008664 DNA replication initiation factor; Provisional; Region: PRK08084 585395008665 uracil transporter; Provisional; Region: PRK10720 585395008666 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585395008667 active site 585395008668 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 585395008669 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 585395008670 dimerization interface [polypeptide binding]; other site 585395008671 putative ATP binding site [chemical binding]; other site 585395008672 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 585395008673 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 585395008674 active site 585395008675 substrate binding site [chemical binding]; other site 585395008676 cosubstrate binding site; other site 585395008677 catalytic site [active] 585395008678 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 585395008679 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 585395008680 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 585395008681 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 585395008682 domain interface [polypeptide binding]; other site 585395008683 active site 585395008684 catalytic site [active] 585395008685 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 585395008686 putative active site [active] 585395008687 catalytic site [active] 585395008688 exopolyphosphatase; Provisional; Region: PRK10854 585395008689 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 585395008690 MASE1; Region: MASE1; pfam05231 585395008691 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585395008692 diguanylate cyclase; Region: GGDEF; smart00267 585395008693 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395008694 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 585395008695 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 585395008696 GMP synthase; Reviewed; Region: guaA; PRK00074 585395008697 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 585395008698 AMP/PPi binding site [chemical binding]; other site 585395008699 candidate oxyanion hole; other site 585395008700 catalytic triad [active] 585395008701 potential glutamine specificity residues [chemical binding]; other site 585395008702 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 585395008703 ATP Binding subdomain [chemical binding]; other site 585395008704 Ligand Binding sites [chemical binding]; other site 585395008705 Dimerization subdomain; other site 585395008706 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 585395008707 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585395008708 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 585395008709 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 585395008710 active site 585395008711 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 585395008712 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 585395008713 generic binding surface II; other site 585395008714 generic binding surface I; other site 585395008715 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 585395008716 GTP-binding protein Der; Reviewed; Region: PRK00093 585395008717 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 585395008718 G1 box; other site 585395008719 GTP/Mg2+ binding site [chemical binding]; other site 585395008720 Switch I region; other site 585395008721 G2 box; other site 585395008722 Switch II region; other site 585395008723 G3 box; other site 585395008724 G4 box; other site 585395008725 G5 box; other site 585395008726 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 585395008727 G1 box; other site 585395008728 GTP/Mg2+ binding site [chemical binding]; other site 585395008729 Switch I region; other site 585395008730 G2 box; other site 585395008731 G3 box; other site 585395008732 Switch II region; other site 585395008733 G4 box; other site 585395008734 G5 box; other site 585395008735 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 585395008736 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 585395008737 Trp docking motif [polypeptide binding]; other site 585395008738 active site 585395008739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 585395008740 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 585395008741 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 585395008742 dimer interface [polypeptide binding]; other site 585395008743 motif 1; other site 585395008744 active site 585395008745 motif 2; other site 585395008746 motif 3; other site 585395008747 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 585395008748 anticodon binding site; other site 585395008749 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 585395008750 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 585395008751 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 585395008752 cytoskeletal protein RodZ; Provisional; Region: PRK10856 585395008753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395008754 non-specific DNA binding site [nucleotide binding]; other site 585395008755 salt bridge; other site 585395008756 sequence-specific DNA binding site [nucleotide binding]; other site 585395008757 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 585395008758 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 585395008759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395008760 FeS/SAM binding site; other site 585395008761 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 585395008762 active site 585395008763 multimer interface [polypeptide binding]; other site 585395008764 penicillin-binding protein 1C; Provisional; Region: PRK11240 585395008765 Transglycosylase; Region: Transgly; pfam00912 585395008766 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585395008767 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 585395008768 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 585395008769 MG2 domain; Region: A2M_N; pfam01835 585395008770 Alpha-2-macroglobulin family; Region: A2M; pfam00207 585395008771 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 585395008772 surface patch; other site 585395008773 thioester region; other site 585395008774 specificity defining residues; other site 585395008775 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 585395008776 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 585395008777 active site residue [active] 585395008778 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 585395008779 active site residue [active] 585395008780 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 585395008781 aminopeptidase B; Provisional; Region: PRK05015 585395008782 Peptidase; Region: DUF3663; pfam12404 585395008783 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 585395008784 interface (dimer of trimers) [polypeptide binding]; other site 585395008785 Substrate-binding/catalytic site; other site 585395008786 Zn-binding sites [ion binding]; other site 585395008787 hypothetical protein; Provisional; Region: PRK10721 585395008788 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585395008789 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585395008790 catalytic loop [active] 585395008791 iron binding site [ion binding]; other site 585395008792 chaperone protein HscA; Provisional; Region: hscA; PRK05183 585395008793 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 585395008794 nucleotide binding site [chemical binding]; other site 585395008795 putative NEF/HSP70 interaction site [polypeptide binding]; other site 585395008796 SBD interface [polypeptide binding]; other site 585395008797 co-chaperone HscB; Provisional; Region: hscB; PRK05014 585395008798 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585395008799 HSP70 interaction site [polypeptide binding]; other site 585395008800 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 585395008801 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 585395008802 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 585395008803 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 585395008804 trimerization site [polypeptide binding]; other site 585395008805 active site 585395008806 cysteine desulfurase; Provisional; Region: PRK14012 585395008807 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 585395008808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585395008809 catalytic residue [active] 585395008810 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 585395008811 Rrf2 family protein; Region: rrf2_super; TIGR00738 585395008812 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 585395008813 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 585395008814 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 585395008815 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 585395008816 active site 585395008817 dimerization interface [polypeptide binding]; other site 585395008818 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 585395008819 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585395008820 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 585395008821 PRD domain; Region: PRD; pfam00874 585395008822 PRD domain; Region: PRD; pfam00874 585395008823 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 585395008824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395008825 putative substrate translocation pore; other site 585395008826 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 585395008827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395008828 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 585395008829 putative dimerization interface [polypeptide binding]; other site 585395008830 putative substrate binding pocket [chemical binding]; other site 585395008831 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 585395008832 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 585395008833 iron-sulfur cluster [ion binding]; other site 585395008834 [2Fe-2S] cluster binding site [ion binding]; other site 585395008835 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 585395008836 beta subunit interface [polypeptide binding]; other site 585395008837 alpha subunit interface [polypeptide binding]; other site 585395008838 active site 585395008839 substrate binding site [chemical binding]; other site 585395008840 Fe binding site [ion binding]; other site 585395008841 3-phenylpropionate dioxygenase, small (beta) subunit, N-terminal fragment 585395008842 putative transposase OrfB; Reviewed; Region: PHA02517 585395008843 HTH-like domain; Region: HTH_21; pfam13276 585395008844 Integrase core domain; Region: rve; pfam00665 585395008845 Integrase core domain; Region: rve_3; pfam13683 585395008846 Transposase; Region: HTH_Tnp_1; cl17663 585395008847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395008848 3-phenylpropionate dioxygenase, small (beta) subunit, C-terminal fragment 585395008849 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 585395008850 [2Fe-2S] cluster binding site [ion binding]; other site 585395008851 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 585395008852 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 585395008853 NAD binding site [chemical binding]; other site 585395008854 active site 585395008855 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 585395008856 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395008857 predicted inner membrane protein, N-terminal fragment 585395008858 predicted inner membrane protein, C-terminal fragment 585395008859 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 585395008860 active site 585395008861 catalytic residues [active] 585395008862 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585395008863 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 585395008864 putative NAD(P) binding site [chemical binding]; other site 585395008865 catalytic Zn binding site [ion binding]; other site 585395008866 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585395008867 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585395008868 TM-ABC transporter signature motif; other site 585395008869 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585395008870 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585395008871 Walker A/P-loop; other site 585395008872 ATP binding site [chemical binding]; other site 585395008873 Q-loop/lid; other site 585395008874 ABC transporter signature motif; other site 585395008875 Walker B; other site 585395008876 D-loop; other site 585395008877 H-loop/switch region; other site 585395008878 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585395008879 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 585395008880 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 585395008881 ligand binding site [chemical binding]; other site 585395008882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585395008883 TPR motif; other site 585395008884 Tetratricopeptide repeat; Region: TPR_16; pfam13432 585395008885 binding surface 585395008886 TPR repeat; Region: TPR_11; pfam13414 585395008887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585395008888 TPR motif; other site 585395008889 binding surface 585395008890 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 585395008891 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585395008892 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585395008893 nucleotide binding site [chemical binding]; other site 585395008894 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 585395008895 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 585395008896 dimer interface [polypeptide binding]; other site 585395008897 active site 585395008898 glycine-pyridoxal phosphate binding site [chemical binding]; other site 585395008899 folate binding site [chemical binding]; other site 585395008900 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 585395008901 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 585395008902 heme-binding site [chemical binding]; other site 585395008903 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 585395008904 FAD binding pocket [chemical binding]; other site 585395008905 FAD binding motif [chemical binding]; other site 585395008906 phosphate binding motif [ion binding]; other site 585395008907 beta-alpha-beta structure motif; other site 585395008908 NAD binding pocket [chemical binding]; other site 585395008909 Heme binding pocket [chemical binding]; other site 585395008910 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 585395008911 Nitrogen regulatory protein P-II; Region: P-II; smart00938 585395008912 response regulator GlrR; Provisional; Region: PRK15115 585395008913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395008914 active site 585395008915 phosphorylation site [posttranslational modification] 585395008916 intermolecular recognition site; other site 585395008917 dimerization interface [polypeptide binding]; other site 585395008918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395008919 Walker A motif; other site 585395008920 ATP binding site [chemical binding]; other site 585395008921 Walker B motif; other site 585395008922 arginine finger; other site 585395008923 hypothetical protein; Provisional; Region: PRK10722 585395008924 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 585395008925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395008926 dimer interface [polypeptide binding]; other site 585395008927 phosphorylation site [posttranslational modification] 585395008928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395008929 ATP binding site [chemical binding]; other site 585395008930 Mg2+ binding site [ion binding]; other site 585395008931 G-X-G motif; other site 585395008932 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 585395008933 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 585395008934 dimerization interface [polypeptide binding]; other site 585395008935 ATP binding site [chemical binding]; other site 585395008936 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 585395008937 dimerization interface [polypeptide binding]; other site 585395008938 ATP binding site [chemical binding]; other site 585395008939 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 585395008940 putative active site [active] 585395008941 catalytic triad [active] 585395008942 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 585395008943 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395008944 substrate binding pocket [chemical binding]; other site 585395008945 membrane-bound complex binding site; other site 585395008946 hinge residues; other site 585395008947 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585395008948 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585395008949 catalytic residue [active] 585395008950 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 585395008951 nucleoside/Zn binding site; other site 585395008952 dimer interface [polypeptide binding]; other site 585395008953 catalytic motif [active] 585395008954 hypothetical protein; Provisional; Region: PRK11590 585395008955 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 585395008956 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585395008957 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 585395008958 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585395008959 putative active site [active] 585395008960 Prophage ECO103_P13, untypable 585395008961 Prophage ECO103_P13; predicted DNA invertase, C-terminal part 585395008962 Prophage ECO103_P13; predicted DNA-invertase, N-terminal part 585395008963 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585395008964 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585395008965 Phage Tail Collar Domain; Region: Collar; pfam07484 585395008966 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 585395008967 Baseplate J-like protein; Region: Baseplate_J; cl01294 585395008968 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 585395008969 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 585395008970 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 585395008971 virion protein; Provisional; Region: V; PHA02564 585395008972 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 585395008973 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 585395008974 Guanylyl transferase CofC like; Region: CofC; cl17472 585395008975 Superfamily II helicase, archaea-specific [General function prediction only]; Region: COG1202 585395008976 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 585395008977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 585395008978 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 585395008979 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 585395008980 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 585395008981 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 585395008982 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 585395008983 large terminase protein; Provisional; Region: 17; PHA02533 585395008984 Terminase small subunit; Region: Terminase_2; pfam03592 585395008985 Pectin methylesterase [Carbohydrate transport and metabolism]; Region: PemB; COG4677 585395008986 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 585395008987 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585395008988 catalytic residue [active] 585395008989 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 585395008990 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585395008991 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 585395008992 polymerase nucleotide-binding site; other site 585395008993 DNA-binding residues [nucleotide binding]; DNA binding site 585395008994 nucleotide binding site [chemical binding]; other site 585395008995 primase nucleotide-binding site [nucleotide binding]; other site 585395008996 Virulence-associated protein E; Region: VirE; pfam05272 585395008997 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395008998 sequence-specific DNA binding site [nucleotide binding]; other site 585395008999 salt bridge; other site 585395009000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395009001 non-specific DNA binding site [nucleotide binding]; other site 585395009002 Predicted transcriptional regulator [Transcription]; Region: COG2932 585395009003 salt bridge; other site 585395009004 sequence-specific DNA binding site [nucleotide binding]; other site 585395009005 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585395009006 Catalytic site [active] 585395009007 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 585395009008 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 585395009009 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 585395009010 active site 585395009011 substrate binding site [chemical binding]; other site 585395009012 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 585395009013 active site 585395009014 DNA binding site [nucleotide binding] 585395009015 catalytic site [active] 585395009016 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 585395009017 VRR-NUC domain; Region: VRR_NUC; pfam08774 585395009018 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 585395009019 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 585395009020 cofactor binding site; other site 585395009021 DNA binding site [nucleotide binding] 585395009022 substrate interaction site [chemical binding]; other site 585395009023 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 585395009024 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 585395009025 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395009026 nucleotide binding region [chemical binding]; other site 585395009027 ATP-binding site [chemical binding]; other site 585395009028 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585395009029 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 585395009030 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 585395009031 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 585395009032 active site 585395009033 hydrophilic channel; other site 585395009034 dimerization interface [polypeptide binding]; other site 585395009035 catalytic residues [active] 585395009036 active site lid [active] 585395009037 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 585395009038 Recombination protein O N terminal; Region: RecO_N; pfam11967 585395009039 Recombination protein O C terminal; Region: RecO_C; pfam02565 585395009040 GTPase Era; Reviewed; Region: era; PRK00089 585395009041 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 585395009042 G1 box; other site 585395009043 GTP/Mg2+ binding site [chemical binding]; other site 585395009044 Switch I region; other site 585395009045 G2 box; other site 585395009046 Switch II region; other site 585395009047 G3 box; other site 585395009048 G4 box; other site 585395009049 G5 box; other site 585395009050 KH domain; Region: KH_2; pfam07650 585395009051 ribonuclease III; Reviewed; Region: rnc; PRK00102 585395009052 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 585395009053 dimerization interface [polypeptide binding]; other site 585395009054 active site 585395009055 metal binding site [ion binding]; metal-binding site 585395009056 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 585395009057 dsRNA binding site [nucleotide binding]; other site 585395009058 signal peptidase I; Provisional; Region: PRK10861 585395009059 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 585395009060 Catalytic site [active] 585395009061 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 585395009062 GTP-binding protein LepA; Provisional; Region: PRK05433 585395009063 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 585395009064 G1 box; other site 585395009065 putative GEF interaction site [polypeptide binding]; other site 585395009066 GTP/Mg2+ binding site [chemical binding]; other site 585395009067 Switch I region; other site 585395009068 G2 box; other site 585395009069 G3 box; other site 585395009070 Switch II region; other site 585395009071 G4 box; other site 585395009072 G5 box; other site 585395009073 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 585395009074 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 585395009075 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 585395009076 SoxR reducing system protein RseC; Provisional; Region: PRK10862 585395009077 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 585395009078 anti-sigma E factor; Provisional; Region: rseB; PRK09455 585395009079 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 585395009080 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 585395009081 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 585395009082 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 585395009083 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585395009084 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585395009085 DNA binding residues [nucleotide binding] 585395009086 L-aspartate oxidase; Provisional; Region: PRK09077 585395009087 L-aspartate oxidase; Provisional; Region: PRK06175 585395009088 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585395009089 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 585395009090 Methyltransferase domain; Region: Methyltransf_26; pfam13659 585395009091 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 585395009092 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585395009093 ATP binding site [chemical binding]; other site 585395009094 Mg++ binding site [ion binding]; other site 585395009095 motif III; other site 585395009096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395009097 nucleotide binding region [chemical binding]; other site 585395009098 ATP-binding site [chemical binding]; other site 585395009099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585395009100 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585395009101 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585395009102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585395009103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395009104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 585395009105 dimerization interface [polypeptide binding]; other site 585395009106 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 585395009107 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 585395009108 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 585395009109 ligand binding site [chemical binding]; other site 585395009110 active site 585395009111 UGI interface [polypeptide binding]; other site 585395009112 catalytic site [active] 585395009113 putative methyltransferase; Provisional; Region: PRK10864 585395009114 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 585395009115 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585395009116 thioredoxin 2; Provisional; Region: PRK10996 585395009117 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 585395009118 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 585395009119 catalytic residues [active] 585395009120 Uncharacterized conserved protein [Function unknown]; Region: COG3148 585395009121 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 585395009122 CoA binding domain; Region: CoA_binding_2; pfam13380 585395009123 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 585395009124 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 585395009125 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 585395009126 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 585395009127 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 585395009128 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 585395009129 domain interface [polypeptide binding]; other site 585395009130 putative active site [active] 585395009131 catalytic site [active] 585395009132 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 585395009133 domain interface [polypeptide binding]; other site 585395009134 putative active site [active] 585395009135 catalytic site [active] 585395009136 lipoprotein; Provisional; Region: PRK10759 585395009137 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 585395009138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395009139 putative substrate translocation pore; other site 585395009140 protein disaggregation chaperone; Provisional; Region: PRK10865 585395009141 Clp amino terminal domain; Region: Clp_N; pfam02861 585395009142 Clp amino terminal domain; Region: Clp_N; pfam02861 585395009143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395009144 Walker A motif; other site 585395009145 ATP binding site [chemical binding]; other site 585395009146 Walker B motif; other site 585395009147 arginine finger; other site 585395009148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395009149 Walker A motif; other site 585395009150 ATP binding site [chemical binding]; other site 585395009151 Walker B motif; other site 585395009152 arginine finger; other site 585395009153 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 585395009154 hypothetical protein; Provisional; Region: PRK10723 585395009155 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 585395009156 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 585395009157 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585395009158 RNA binding surface [nucleotide binding]; other site 585395009159 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585395009160 active site 585395009161 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 585395009162 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 585395009163 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 585395009164 30S subunit binding site; other site 585395009165 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 585395009166 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 585395009167 Prephenate dehydratase; Region: PDT; pfam00800 585395009168 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 585395009169 putative L-Phe binding site [chemical binding]; other site 585395009170 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 585395009171 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 585395009172 prephenate dehydrogenase; Validated; Region: PRK08507 585395009173 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 585395009174 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585395009175 lipoprotein; Provisional; Region: PRK11443 585395009176 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 585395009177 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 585395009178 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 585395009179 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395009180 metal binding site [ion binding]; metal-binding site 585395009181 active site 585395009182 I-site; other site 585395009183 putative outer membrane lipoprotein; Provisional; Region: PRK09967 585395009184 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585395009185 ligand binding site [chemical binding]; other site 585395009186 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 585395009187 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 585395009188 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 585395009189 RimM N-terminal domain; Region: RimM; pfam01782 585395009190 PRC-barrel domain; Region: PRC; pfam05239 585395009191 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 585395009192 signal recognition particle protein; Provisional; Region: PRK10867 585395009193 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 585395009194 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 585395009195 P loop; other site 585395009196 GTP binding site [chemical binding]; other site 585395009197 Signal peptide binding domain; Region: SRP_SPB; pfam02978 585395009198 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 585395009199 hypothetical protein; Provisional; Region: PRK11573 585395009200 Domain of unknown function DUF21; Region: DUF21; pfam01595 585395009201 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585395009202 Transporter associated domain; Region: CorC_HlyC; smart01091 585395009203 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 585395009204 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 585395009205 dimer interface [polypeptide binding]; other site 585395009206 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 585395009207 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 585395009208 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 585395009209 recombination and repair protein; Provisional; Region: PRK10869 585395009210 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 585395009211 Walker A/P-loop; other site 585395009212 ATP binding site [chemical binding]; other site 585395009213 Q-loop/lid; other site 585395009214 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 585395009215 Q-loop/lid; other site 585395009216 ABC transporter signature motif; other site 585395009217 Walker B; other site 585395009218 D-loop; other site 585395009219 H-loop/switch region; other site 585395009220 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 585395009221 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 585395009222 hypothetical protein; Validated; Region: PRK01777 585395009223 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 585395009224 putative coenzyme Q binding site [chemical binding]; other site 585395009225 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 585395009226 SmpB-tmRNA interface; other site 585395009227 Integrative element ECO103_IE01 585395009228 integrase; Provisional; Region: PRK09692 585395009229 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585395009230 active site 585395009231 Int/Topo IB signature motif; other site 585395009232 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 585395009233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395009234 ATP binding site [chemical binding]; other site 585395009235 Mg2+ binding site [ion binding]; other site 585395009236 G-X-G motif; other site 585395009237 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 585395009238 active site 585395009239 catalytic site [active] 585395009240 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 585395009241 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 585395009242 substrate binding pocket [chemical binding]; other site 585395009243 active site 585395009244 iron coordination sites [ion binding]; other site 585395009245 Predicted dehydrogenase [General function prediction only]; Region: COG0579 585395009246 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585395009247 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 585395009248 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 585395009249 tetramerization interface [polypeptide binding]; other site 585395009250 NAD(P) binding site [chemical binding]; other site 585395009251 catalytic residues [active] 585395009252 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 585395009253 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585395009254 inhibitor-cofactor binding pocket; inhibition site 585395009255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395009256 catalytic residue [active] 585395009257 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 585395009258 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 585395009259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395009260 DNA-binding site [nucleotide binding]; DNA binding site 585395009261 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585395009262 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 585395009263 bacterial OsmY and nodulation domain; Region: BON; smart00749 585395009264 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585395009265 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 585395009266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585395009267 dimerization interface [polypeptide binding]; other site 585395009268 putative DNA binding site [nucleotide binding]; other site 585395009269 Transcriptional regulators [Transcription]; Region: MarR; COG1846 585395009270 putative Zn2+ binding site [ion binding]; other site 585395009271 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 585395009272 active site residue [active] 585395009273 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 585395009274 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 585395009275 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585395009276 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 585395009277 hypothetical protein; Provisional; Region: PRK10556 585395009278 hypothetical protein; Provisional; Region: PRK10132 585395009279 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 585395009280 catalytic residues [active] 585395009281 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 585395009282 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 585395009283 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 585395009284 Class I ribonucleotide reductase; Region: RNR_I; cd01679 585395009285 active site 585395009286 dimer interface [polypeptide binding]; other site 585395009287 catalytic residues [active] 585395009288 effector binding site; other site 585395009289 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 585395009290 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 585395009291 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 585395009292 dimer interface [polypeptide binding]; other site 585395009293 putative radical transfer pathway; other site 585395009294 diiron center [ion binding]; other site 585395009295 tyrosyl radical; other site 585395009296 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 585395009297 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 585395009298 Walker A/P-loop; other site 585395009299 ATP binding site [chemical binding]; other site 585395009300 Q-loop/lid; other site 585395009301 ABC transporter signature motif; other site 585395009302 Walker B; other site 585395009303 D-loop; other site 585395009304 H-loop/switch region; other site 585395009305 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 585395009306 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 585395009307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395009308 dimer interface [polypeptide binding]; other site 585395009309 conserved gate region; other site 585395009310 putative PBP binding loops; other site 585395009311 ABC-ATPase subunit interface; other site 585395009312 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 585395009313 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 585395009314 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 585395009315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395009316 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 585395009317 putative L-valine exporter; Provisional; Region: PRK10408 585395009318 transcriptional repressor MprA; Provisional; Region: PRK10870 585395009319 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585395009320 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 585395009321 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395009322 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395009323 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 585395009324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395009325 putative substrate translocation pore; other site 585395009326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395009327 S-ribosylhomocysteinase; Provisional; Region: PRK02260 585395009328 glutamate--cysteine ligase; Provisional; Region: PRK02107 585395009329 Predicted membrane protein [Function unknown]; Region: COG1238 585395009330 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 585395009331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395009332 motif II; other site 585395009333 carbon storage regulator; Provisional; Region: PRK01712 585395009334 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 585395009335 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 585395009336 motif 1; other site 585395009337 active site 585395009338 motif 2; other site 585395009339 motif 3; other site 585395009340 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 585395009341 DHHA1 domain; Region: DHHA1; pfam02272 585395009342 recombination regulator RecX; Reviewed; Region: recX; PRK00117 585395009343 recombinase A; Provisional; Region: recA; PRK09354 585395009344 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 585395009345 hexamer interface [polypeptide binding]; other site 585395009346 Walker A motif; other site 585395009347 ATP binding site [chemical binding]; other site 585395009348 Walker B motif; other site 585395009349 hypothetical protein; Validated; Region: PRK03661 585395009350 Transglycosylase SLT domain; Region: SLT_2; pfam13406 585395009351 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585395009352 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585395009353 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 585395009354 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 585395009355 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 585395009356 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 585395009357 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 585395009358 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 585395009359 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 585395009360 putative NAD(P) binding site [chemical binding]; other site 585395009361 active site 585395009362 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 585395009363 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 585395009364 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585395009365 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585395009366 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 585395009367 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 585395009368 putative active site [active] 585395009369 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 585395009370 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 585395009371 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585395009372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395009373 Walker A motif; other site 585395009374 ATP binding site [chemical binding]; other site 585395009375 Walker B motif; other site 585395009376 arginine finger; other site 585395009377 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 585395009378 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 585395009379 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 585395009380 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 585395009381 iron binding site [ion binding]; other site 585395009382 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 585395009383 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585395009384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395009385 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 585395009386 Acylphosphatase; Region: Acylphosphatase; pfam00708 585395009387 HypF finger; Region: zf-HYPF; pfam07503 585395009388 HypF finger; Region: zf-HYPF; pfam07503 585395009389 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 585395009390 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 585395009391 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 585395009392 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585395009393 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585395009394 DNA binding site [nucleotide binding] 585395009395 domain linker motif; other site 585395009396 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585395009397 dimerization interface (closed form) [polypeptide binding]; other site 585395009398 ligand binding site [chemical binding]; other site 585395009399 fused cellobiose/arbutin/salicin-specific PTS enzymes: IIB component/IC component, N-terminal fragment 585395009400 fused cellobiose/arbutin/salicin-specific PTS enzymes: IIB component/IC component, C-terminal fragment 585395009401 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 585395009402 beta-galactosidase; Region: BGL; TIGR03356 585395009403 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395009404 non-specific DNA binding site [nucleotide binding]; other site 585395009405 salt bridge; other site 585395009406 sequence-specific DNA binding site [nucleotide binding]; other site 585395009407 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 585395009408 nickel binding site [ion binding]; other site 585395009409 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 585395009410 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 585395009411 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 585395009412 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585395009413 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 585395009414 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 585395009415 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 585395009416 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 585395009417 NADH dehydrogenase; Region: NADHdh; cl00469 585395009418 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 585395009419 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585395009420 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585395009421 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 585395009422 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 585395009423 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 585395009424 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 585395009425 hydrogenase assembly chaperone; Provisional; Region: PRK10409 585395009426 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 585395009427 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 585395009428 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 585395009429 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 585395009430 dimerization interface [polypeptide binding]; other site 585395009431 ATP binding site [chemical binding]; other site 585395009432 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 585395009433 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585395009434 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585395009435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395009436 Walker A motif; other site 585395009437 ATP binding site [chemical binding]; other site 585395009438 Walker B motif; other site 585395009439 arginine finger; other site 585395009440 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 585395009441 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 585395009442 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 585395009443 MutS domain I; Region: MutS_I; pfam01624 585395009444 MutS domain II; Region: MutS_II; pfam05188 585395009445 MutS domain III; Region: MutS_III; pfam05192 585395009446 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 585395009447 Walker A/P-loop; other site 585395009448 ATP binding site [chemical binding]; other site 585395009449 Q-loop/lid; other site 585395009450 ABC transporter signature motif; other site 585395009451 Walker B; other site 585395009452 D-loop; other site 585395009453 H-loop/switch region; other site 585395009454 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 585395009455 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585395009456 active site 585395009457 metal binding site [ion binding]; metal-binding site 585395009458 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585395009459 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585395009460 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585395009461 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 585395009462 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585395009463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 585395009464 putative aldolase; Validated; Region: PRK08130 585395009465 active site 585395009466 intersubunit interface [polypeptide binding]; other site 585395009467 Zn2+ binding site [ion binding]; other site 585395009468 hypothetical protein; Provisional; Region: PRK09989 585395009469 putative transporter; Provisional; Region: PRK09821 585395009470 GntP family permease; Region: GntP_permease; pfam02447 585395009471 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 585395009472 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 585395009473 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 585395009474 Flavoprotein; Region: Flavoprotein; pfam02441 585395009475 MarR family; Region: MarR_2; cl17246 585395009476 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585395009477 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 585395009478 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 585395009479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585395009480 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585395009481 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585395009482 DNA binding residues [nucleotide binding] 585395009483 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 585395009484 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585395009485 Peptidase family M23; Region: Peptidase_M23; pfam01551 585395009486 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 585395009487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395009488 S-adenosylmethionine binding site [chemical binding]; other site 585395009489 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 585395009490 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 585395009491 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 585395009492 Permutation of conserved domain; other site 585395009493 active site 585395009494 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 585395009495 homotrimer interaction site [polypeptide binding]; other site 585395009496 zinc binding site [ion binding]; other site 585395009497 CDP-binding sites; other site 585395009498 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 585395009499 substrate binding site; other site 585395009500 dimer interface; other site 585395009501 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 585395009502 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 585395009503 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 585395009504 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 585395009505 ligand-binding site [chemical binding]; other site 585395009506 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 585395009507 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 585395009508 CysD dimerization site [polypeptide binding]; other site 585395009509 G1 box; other site 585395009510 putative GEF interaction site [polypeptide binding]; other site 585395009511 GTP/Mg2+ binding site [chemical binding]; other site 585395009512 Switch I region; other site 585395009513 G2 box; other site 585395009514 G3 box; other site 585395009515 Switch II region; other site 585395009516 G4 box; other site 585395009517 G5 box; other site 585395009518 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 585395009519 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 585395009520 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 585395009521 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585395009522 Active Sites [active] 585395009523 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 585395009524 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 585395009525 metal binding site [ion binding]; metal-binding site 585395009526 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 585395009527 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 585395009528 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 585395009529 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 585395009530 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 585395009531 conserved predicted protein, C-terminal fragment 585395009532 conserved predicted protein, N-terminal fragment 585395009533 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 585395009534 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 585395009535 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 585395009536 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 585395009537 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 585395009538 Hok/gef family; Region: HOK_GEF; pfam01848 585395009539 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 585395009540 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585395009541 Active Sites [active] 585395009542 sulfite reductase subunit beta; Provisional; Region: PRK13504 585395009543 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585395009544 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585395009545 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 585395009546 Flavodoxin; Region: Flavodoxin_1; pfam00258 585395009547 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 585395009548 FAD binding pocket [chemical binding]; other site 585395009549 FAD binding motif [chemical binding]; other site 585395009550 catalytic residues [active] 585395009551 NAD binding pocket [chemical binding]; other site 585395009552 phosphate binding motif [ion binding]; other site 585395009553 beta-alpha-beta structure motif; other site 585395009554 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 585395009555 homohexamer interface [polypeptide binding]; other site 585395009556 putative substrate stabilizing pore; other site 585395009557 pterin binding site; other site 585395009558 oxidoreductase; Provisional; Region: PRK10015 585395009559 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 585395009560 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 585395009561 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 585395009562 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 585395009563 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 585395009564 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 585395009565 Ligand binding site [chemical binding]; other site 585395009566 Electron transfer flavoprotein domain; Region: ETF; pfam01012 585395009567 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 585395009568 benzoate transport; Region: 2A0115; TIGR00895 585395009569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395009570 putative substrate translocation pore; other site 585395009571 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 585395009572 FAD binding domain; Region: FAD_binding_4; pfam01565 585395009573 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 585395009574 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 585395009575 NADP binding site [chemical binding]; other site 585395009576 homodimer interface [polypeptide binding]; other site 585395009577 active site 585395009578 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585395009579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395009580 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 585395009581 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585395009582 nucleotide binding site [chemical binding]; other site 585395009583 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 585395009584 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 585395009585 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 585395009586 Repair protein; Region: Repair_PSII; pfam04536 585395009587 enolase; Provisional; Region: eno; PRK00077 585395009588 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 585395009589 dimer interface [polypeptide binding]; other site 585395009590 metal binding site [ion binding]; metal-binding site 585395009591 substrate binding pocket [chemical binding]; other site 585395009592 CTP synthetase; Validated; Region: pyrG; PRK05380 585395009593 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 585395009594 Catalytic site [active] 585395009595 active site 585395009596 UTP binding site [chemical binding]; other site 585395009597 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 585395009598 active site 585395009599 putative oxyanion hole; other site 585395009600 catalytic triad [active] 585395009601 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 585395009602 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 585395009603 homodimer interface [polypeptide binding]; other site 585395009604 metal binding site [ion binding]; metal-binding site 585395009605 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 585395009606 homodimer interface [polypeptide binding]; other site 585395009607 active site 585395009608 putative chemical substrate binding site [chemical binding]; other site 585395009609 metal binding site [ion binding]; metal-binding site 585395009610 toxin MazF; Provisional; Region: PRK09907 585395009611 antitoxin MazE; Provisional; Region: PRK09798 585395009612 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 585395009613 HD domain; Region: HD_4; pfam13328 585395009614 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 585395009615 synthetase active site [active] 585395009616 NTP binding site [chemical binding]; other site 585395009617 metal binding site [ion binding]; metal-binding site 585395009618 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 585395009619 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 585395009620 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 585395009621 TRAM domain; Region: TRAM; pfam01938 585395009622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395009623 S-adenosylmethionine binding site [chemical binding]; other site 585395009624 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 585395009625 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 585395009626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585395009627 dimerization interface [polypeptide binding]; other site 585395009628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395009629 dimer interface [polypeptide binding]; other site 585395009630 phosphorylation site [posttranslational modification] 585395009631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395009632 ATP binding site [chemical binding]; other site 585395009633 Mg2+ binding site [ion binding]; other site 585395009634 G-X-G motif; other site 585395009635 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 585395009636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395009637 active site 585395009638 phosphorylation site [posttranslational modification] 585395009639 intermolecular recognition site; other site 585395009640 dimerization interface [polypeptide binding]; other site 585395009641 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585395009642 putative binding surface; other site 585395009643 active site 585395009644 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 585395009645 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 585395009646 active site 585395009647 tetramer interface [polypeptide binding]; other site 585395009648 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 585395009649 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 585395009650 active site 585395009651 tetramer interface [polypeptide binding]; other site 585395009652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395009653 D-galactonate transporter; Region: 2A0114; TIGR00893 585395009654 putative substrate translocation pore; other site 585395009655 flavodoxin; Provisional; Region: PRK08105 585395009656 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 585395009657 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 585395009658 probable active site [active] 585395009659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 585395009660 SecY interacting protein Syd; Provisional; Region: PRK04968 585395009661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 585395009662 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 585395009663 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 585395009664 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 585395009665 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 585395009666 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585395009667 serine transporter; Region: stp; TIGR00814 585395009668 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 585395009669 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585395009670 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585395009671 flap endonuclease-like protein; Provisional; Region: PRK09482 585395009672 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 585395009673 active site 585395009674 metal binding site 1 [ion binding]; metal-binding site 585395009675 putative 5' ssDNA interaction site; other site 585395009676 metal binding site 3; metal-binding site 585395009677 metal binding site 2 [ion binding]; metal-binding site 585395009678 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 585395009679 putative DNA binding site [nucleotide binding]; other site 585395009680 putative metal binding site [ion binding]; other site 585395009681 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 585395009682 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 585395009683 dimer interface [polypeptide binding]; other site 585395009684 active site 585395009685 metal binding site [ion binding]; metal-binding site 585395009686 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585395009687 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585395009688 intersubunit interface [polypeptide binding]; other site 585395009689 active site 585395009690 Zn2+ binding site [ion binding]; other site 585395009691 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 585395009692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395009693 putative substrate translocation pore; other site 585395009694 L-fucose isomerase; Provisional; Region: fucI; PRK10991 585395009695 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 585395009696 hexamer (dimer of trimers) interface [polypeptide binding]; other site 585395009697 trimer interface [polypeptide binding]; other site 585395009698 substrate binding site [chemical binding]; other site 585395009699 Mn binding site [ion binding]; other site 585395009700 L-fuculokinase; Provisional; Region: PRK10331 585395009701 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585395009702 nucleotide binding site [chemical binding]; other site 585395009703 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 585395009704 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 585395009705 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585395009706 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585395009707 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 585395009708 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 585395009709 hypothetical protein; Provisional; Region: PRK10873 585395009710 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 585395009711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395009712 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 585395009713 dimerization interface [polypeptide binding]; other site 585395009714 substrate binding pocket [chemical binding]; other site 585395009715 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 585395009716 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 585395009717 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 585395009718 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585395009719 catalytic residue [active] 585395009720 CsdA-binding activator; Provisional; Region: PRK15019 585395009721 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 585395009722 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 585395009723 putative ATP binding site [chemical binding]; other site 585395009724 putative substrate interface [chemical binding]; other site 585395009725 murein transglycosylase A; Provisional; Region: mltA; PRK11162 585395009726 MltA specific insert domain; Region: MltA; pfam03562 585395009727 3D domain; Region: 3D; pfam06725 585395009728 Protein of unknown function (DUF770); Region: DUF770; pfam05591 585395009729 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 585395009730 Protein of unknown function (DUF877); Region: DUF877; pfam05943 585395009731 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 585395009732 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 585395009733 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 585395009734 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 585395009735 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585395009736 ligand binding site [chemical binding]; other site 585395009737 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585395009738 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 585395009739 Clp amino terminal domain; Region: Clp_N; pfam02861 585395009740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395009741 Walker A motif; other site 585395009742 ATP binding site [chemical binding]; other site 585395009743 Walker B motif; other site 585395009744 arginine finger; other site 585395009745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395009746 Walker A motif; other site 585395009747 ATP binding site [chemical binding]; other site 585395009748 Walker B motif; other site 585395009749 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 585395009750 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 585395009751 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585395009752 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585395009753 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585395009754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 585395009755 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585395009756 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585395009757 catalytic residue [active] 585395009758 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 585395009759 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 585395009760 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 585395009761 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585395009762 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 585395009763 PAAR motif; Region: PAAR_motif; pfam05488 585395009764 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 585395009765 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 585395009766 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 585395009767 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 585395009768 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 585395009769 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585395009770 ImpA domain protein; Region: DUF3702; pfam12486 585395009771 AMIN domain; Region: AMIN; pfam11741 585395009772 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585395009773 active site 585395009774 metal binding site [ion binding]; metal-binding site 585395009775 N-acetylglutamate synthase; Validated; Region: PRK05279 585395009776 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 585395009777 putative feedback inhibition sensing region; other site 585395009778 putative nucleotide binding site [chemical binding]; other site 585395009779 putative substrate binding site [chemical binding]; other site 585395009780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395009781 Coenzyme A binding pocket [chemical binding]; other site 585395009782 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 585395009783 AAA domain; Region: AAA_30; pfam13604 585395009784 Family description; Region: UvrD_C_2; pfam13538 585395009785 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 585395009786 protease3; Provisional; Region: PRK15101 585395009787 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 585395009788 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585395009789 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585395009790 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 585395009791 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 585395009792 hypothetical protein; Provisional; Region: PRK10332 585395009793 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 585395009794 hypothetical protein; Provisional; Region: PRK11521 585395009795 hypothetical protein; Provisional; Region: PRK10557 585395009796 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585395009797 hypothetical protein; Provisional; Region: PRK10506 585395009798 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585395009799 thymidylate synthase; Reviewed; Region: thyA; PRK01827 585395009800 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 585395009801 dimerization interface [polypeptide binding]; other site 585395009802 active site 585395009803 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 585395009804 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 585395009805 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585395009806 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585395009807 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585395009808 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585395009809 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 585395009810 putative active site [active] 585395009811 Ap4A binding site [chemical binding]; other site 585395009812 nudix motif; other site 585395009813 putative metal binding site [ion binding]; other site 585395009814 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 585395009815 putative DNA-binding cleft [nucleotide binding]; other site 585395009816 putative DNA clevage site; other site 585395009817 molecular lever; other site 585395009818 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585395009819 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 585395009820 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585395009821 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585395009822 active site 585395009823 catalytic tetrad [active] 585395009824 lysophospholipid transporter LplT; Provisional; Region: PRK11195 585395009825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395009826 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 585395009827 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 585395009828 putative acyl-acceptor binding pocket; other site 585395009829 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 585395009830 acyl-activating enzyme (AAE) consensus motif; other site 585395009831 putative AMP binding site [chemical binding]; other site 585395009832 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 585395009833 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585395009834 DNA binding site [nucleotide binding] 585395009835 domain linker motif; other site 585395009836 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585395009837 dimerization interface (closed form) [polypeptide binding]; other site 585395009838 ligand binding site [chemical binding]; other site 585395009839 diaminopimelate decarboxylase; Provisional; Region: PRK11165 585395009840 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 585395009841 active site 585395009842 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585395009843 substrate binding site [chemical binding]; other site 585395009844 catalytic residues [active] 585395009845 dimer interface [polypeptide binding]; other site 585395009846 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 585395009847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395009848 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 585395009849 putative dimerization interface [polypeptide binding]; other site 585395009850 putative racemase; Provisional; Region: PRK10200 585395009851 aspartate racemase; Region: asp_race; TIGR00035 585395009852 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 585395009853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395009854 putative substrate translocation pore; other site 585395009855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395009856 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 585395009857 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 585395009858 NADP binding site [chemical binding]; other site 585395009859 homodimer interface [polypeptide binding]; other site 585395009860 active site 585395009861 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 585395009862 putative acyltransferase; Provisional; Region: PRK05790 585395009863 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585395009864 dimer interface [polypeptide binding]; other site 585395009865 active site 585395009866 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585395009867 serine transporter; Region: stp; TIGR00814 585395009868 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 585395009869 DNA binding residues [nucleotide binding] 585395009870 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 585395009871 conserved predicted protein, C-terminal part 585395009872 conserved predicted protein, N-terminal part 585395009873 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 585395009874 Tetratricopeptide repeat; Region: TPR_3; pfam07720 585395009875 Tetratricopeptide repeat; Region: TPR_3; pfam07720 585395009876 transcriptional regulator; Provisional; Region: PRK11906 585395009877 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 585395009878 DNA binding site [nucleotide binding] 585395009879 Tetratricopeptide repeat; Region: TPR_2; pfam07719 585395009880 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 585395009881 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585395009882 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585395009883 catalytic residue [active] 585395009884 two component transcriptional regulator, N-terminal truncated 585395009885 predicted two component transcriptional regulator, N-terminal fragment 585395009886 invasion protein OrgB; Provisional; Region: PRK15322 585395009887 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 585395009888 predicted type III secretion system lipoprotein precursor EprK, C-terminal part 585395009889 predicted type III secretion system lipoprotein precursor EprK, N-terminal part 585395009890 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 585395009891 Type III secretion needle MxiH like; Region: MxiH; cl09641 585395009892 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 585395009893 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 585395009894 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 585395009895 DNA binding residues [nucleotide binding] 585395009896 type III secretion protein EprS, C-terminal part 585395009897 type III secretion protein EprS, N-terminal part 585395009898 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 585395009899 type III secretion system protein SpaQ; Provisional; Region: PRK15333 585395009900 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 585395009901 predicted type III secretion protein EpaO, C-termnal part 585395009902 predicted typeIII secretion apparatus protein, N-terminal part 585395009903 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 585395009904 Integrative element ECO103_IE02 585395009905 Transposase; Region: HTH_Tnp_1; cl17663 585395009906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395009907 putative transposase OrfB; Reviewed; Region: PHA02517 585395009908 HTH-like domain; Region: HTH_21; pfam13276 585395009909 Integrase core domain; Region: rve; pfam00665 585395009910 Integrase core domain; Region: rve_3; pfam13683 585395009911 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 585395009912 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585395009913 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 585395009914 Int/Topo IB signature motif; other site 585395009915 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585395009916 Peptidase family M23; Region: Peptidase_M23; pfam01551 585395009917 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 585395009918 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 585395009919 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 585395009920 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 585395009921 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 585395009922 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 585395009923 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585395009924 catalytic loop [active] 585395009925 iron binding site [ion binding]; other site 585395009926 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 585395009927 GAF domain; Region: GAF; cl17456 585395009928 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 585395009929 PAS domain; Region: PAS; smart00091 585395009930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395009931 Walker A motif; other site 585395009932 ATP binding site [chemical binding]; other site 585395009933 Walker B motif; other site 585395009934 arginine finger; other site 585395009935 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585395009936 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 585395009937 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585395009938 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585395009939 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 585395009940 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 585395009941 catalytic residue [active] 585395009942 peptidase; Reviewed; Region: PRK13004 585395009943 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 585395009944 putative metal binding site [ion binding]; other site 585395009945 putative dimer interface [polypeptide binding]; other site 585395009946 D-hydantoinase; Region: D-hydantoinase; TIGR02033 585395009947 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 585395009948 tetramer interface [polypeptide binding]; other site 585395009949 active site 585395009950 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585395009951 carbamate kinase; Reviewed; Region: PRK12686 585395009952 putative substrate binding site [chemical binding]; other site 585395009953 homodimer interface [polypeptide binding]; other site 585395009954 nucleotide binding site [chemical binding]; other site 585395009955 nucleotide binding site [chemical binding]; other site 585395009956 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 585395009957 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 585395009958 XdhC Rossmann domain; Region: XdhC_C; pfam13478 585395009959 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 585395009960 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 585395009961 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 585395009962 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 585395009963 Ligand binding site; other site 585395009964 metal-binding site 585395009965 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 585395009966 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585395009967 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585395009968 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395009969 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 585395009970 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 585395009971 active site 585395009972 putative substrate binding pocket [chemical binding]; other site 585395009973 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 585395009974 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 585395009975 putative hypoxanthine oxidase; Provisional; Region: PRK09800 585395009976 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 585395009977 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 585395009978 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 585395009979 uracil-xanthine permease; Region: ncs2; TIGR00801 585395009980 guanine deaminase; Provisional; Region: PRK09228 585395009981 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 585395009982 active site 585395009983 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585395009984 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585395009985 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 585395009986 4Fe-4S binding domain; Region: Fer4; pfam00037 585395009987 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585395009988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395009989 xanthine permease; Region: pbuX; TIGR03173 585395009990 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 585395009991 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 585395009992 active site 585395009993 metal binding site [ion binding]; metal-binding site 585395009994 nudix motif; other site 585395009995 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 585395009996 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 585395009997 dimer interface [polypeptide binding]; other site 585395009998 putative anticodon binding site; other site 585395009999 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 585395010000 motif 1; other site 585395010001 active site 585395010002 motif 2; other site 585395010003 motif 3; other site 585395010004 peptide chain release factor 2; Validated; Region: prfB; PRK00578 585395010005 This domain is found in peptide chain release factors; Region: PCRF; smart00937 585395010006 RF-1 domain; Region: RF-1; pfam00472 585395010007 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 585395010008 DHH family; Region: DHH; pfam01368 585395010009 DHHA1 domain; Region: DHHA1; pfam02272 585395010010 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 585395010011 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 585395010012 dimerization domain [polypeptide binding]; other site 585395010013 dimer interface [polypeptide binding]; other site 585395010014 catalytic residues [active] 585395010015 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 585395010016 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 585395010017 active site 585395010018 Int/Topo IB signature motif; other site 585395010019 flavodoxin FldB; Provisional; Region: PRK12359 585395010020 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 585395010021 hypothetical protein; Provisional; Region: PRK10878 585395010022 putative global regulator; Reviewed; Region: PRK09559 585395010023 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 585395010024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585395010025 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585395010026 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585395010027 hemolysin; Provisional; Region: PRK15087 585395010028 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 585395010029 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 585395010030 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 585395010031 beta-galactosidase; Region: BGL; TIGR03356 585395010032 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 585395010033 classical (c) SDRs; Region: SDR_c; cd05233 585395010034 NAD(P) binding site [chemical binding]; other site 585395010035 active site 585395010036 glycine dehydrogenase; Provisional; Region: PRK05367 585395010037 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 585395010038 tetramer interface [polypeptide binding]; other site 585395010039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395010040 catalytic residue [active] 585395010041 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 585395010042 tetramer interface [polypeptide binding]; other site 585395010043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395010044 catalytic residue [active] 585395010045 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 585395010046 lipoyl attachment site [posttranslational modification]; other site 585395010047 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 585395010048 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 585395010049 oxidoreductase; Provisional; Region: PRK08013 585395010050 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 585395010051 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 585395010052 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 585395010053 proline aminopeptidase P II; Provisional; Region: PRK10879 585395010054 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 585395010055 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 585395010056 active site 585395010057 hypothetical protein; Reviewed; Region: PRK01736 585395010058 Z-ring-associated protein; Provisional; Region: PRK10972 585395010059 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 585395010060 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 585395010061 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 585395010062 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 585395010063 ligand binding site [chemical binding]; other site 585395010064 NAD binding site [chemical binding]; other site 585395010065 tetramer interface [polypeptide binding]; other site 585395010066 catalytic site [active] 585395010067 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 585395010068 L-serine binding site [chemical binding]; other site 585395010069 ACT domain interface; other site 585395010070 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 585395010071 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585395010072 active site 585395010073 dimer interface [polypeptide binding]; other site 585395010074 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 585395010075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395010076 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 585395010077 putative dimerization interface [polypeptide binding]; other site 585395010078 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 585395010079 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 585395010080 active site 585395010081 substrate binding site [chemical binding]; other site 585395010082 coenzyme B12 binding site [chemical binding]; other site 585395010083 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 585395010084 B12 binding site [chemical binding]; other site 585395010085 cobalt ligand [ion binding]; other site 585395010086 membrane ATPase/protein kinase; Provisional; Region: PRK09435 585395010087 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 585395010088 Walker A; other site 585395010089 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 585395010090 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585395010091 substrate binding site [chemical binding]; other site 585395010092 oxyanion hole (OAH) forming residues; other site 585395010093 trimer interface [polypeptide binding]; other site 585395010094 propionyl-CoA:succinate-CoA transferase, N-terminal fragment 585395010095 propionyl-CoA:succinate-CoA transferase, C-terminal fragment 585395010096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395010097 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585395010098 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585395010099 dimerization interface [polypeptide binding]; other site 585395010100 Uncharacterized conserved protein [Function unknown]; Region: COG2968 585395010101 oxidative stress defense protein; Provisional; Region: PRK11087 585395010102 arginine exporter protein; Provisional; Region: PRK09304 585395010103 mechanosensitive channel MscS; Provisional; Region: PRK10334 585395010104 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585395010105 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585395010106 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 585395010107 active site 585395010108 intersubunit interface [polypeptide binding]; other site 585395010109 zinc binding site [ion binding]; other site 585395010110 Na+ binding site [ion binding]; other site 585395010111 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 585395010112 Phosphoglycerate kinase; Region: PGK; pfam00162 585395010113 substrate binding site [chemical binding]; other site 585395010114 hinge regions; other site 585395010115 ADP binding site [chemical binding]; other site 585395010116 catalytic site [active] 585395010117 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 585395010118 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585395010119 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585395010120 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 585395010121 trimer interface [polypeptide binding]; other site 585395010122 putative Zn binding site [ion binding]; other site 585395010123 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 585395010124 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 585395010125 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 585395010126 Walker A/P-loop; other site 585395010127 ATP binding site [chemical binding]; other site 585395010128 Q-loop/lid; other site 585395010129 ABC transporter signature motif; other site 585395010130 Walker B; other site 585395010131 D-loop; other site 585395010132 H-loop/switch region; other site 585395010133 ABC-transporter ATP-binding subunit, N-terminal fragment 585395010134 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 585395010135 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 585395010136 active site 585395010137 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 585395010138 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 585395010139 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 585395010140 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 585395010141 putative active site [active] 585395010142 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 585395010143 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585395010144 putative NAD(P) binding site [chemical binding]; other site 585395010145 catalytic Zn binding site [ion binding]; other site 585395010146 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 585395010147 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 585395010148 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 585395010149 active site 585395010150 P-loop; other site 585395010151 phosphorylation site [posttranslational modification] 585395010152 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585395010153 active site 585395010154 phosphorylation site [posttranslational modification] 585395010155 transketolase; Reviewed; Region: PRK12753 585395010156 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 585395010157 TPP-binding site [chemical binding]; other site 585395010158 dimer interface [polypeptide binding]; other site 585395010159 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585395010160 PYR/PP interface [polypeptide binding]; other site 585395010161 dimer interface [polypeptide binding]; other site 585395010162 TPP binding site [chemical binding]; other site 585395010163 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585395010164 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 585395010165 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 585395010166 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 585395010167 agmatinase; Region: agmatinase; TIGR01230 585395010168 oligomer interface [polypeptide binding]; other site 585395010169 putative active site [active] 585395010170 Mn binding site [ion binding]; other site 585395010171 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 585395010172 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 585395010173 dimer interface [polypeptide binding]; other site 585395010174 active site 585395010175 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585395010176 catalytic residues [active] 585395010177 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 585395010178 Virulence promoting factor; Region: YqgB; pfam11036 585395010179 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 585395010180 S-adenosylmethionine synthetase; Validated; Region: PRK05250 585395010181 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 585395010182 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 585395010183 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 585395010184 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 585395010185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395010186 putative substrate translocation pore; other site 585395010187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395010188 hypothetical protein; Provisional; Region: PRK04860 585395010189 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 585395010190 DNA-specific endonuclease I; Provisional; Region: PRK15137 585395010191 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 585395010192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 585395010193 RNA methyltransferase, RsmE family; Region: TIGR00046 585395010194 glutathione synthetase; Provisional; Region: PRK05246 585395010195 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 585395010196 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 585395010197 hypothetical protein; Validated; Region: PRK00228 585395010198 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 585395010199 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 585395010200 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 585395010201 Walker A motif; other site 585395010202 ATP binding site [chemical binding]; other site 585395010203 Walker B motif; other site 585395010204 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 585395010205 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585395010206 catalytic residue [active] 585395010207 YGGT family; Region: YGGT; pfam02325 585395010208 YGGT family; Region: YGGT; pfam02325 585395010209 hypothetical protein; Validated; Region: PRK05090 585395010210 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 585395010211 active site 585395010212 dimerization interface [polypeptide binding]; other site 585395010213 HemN family oxidoreductase; Provisional; Region: PRK05660 585395010214 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395010215 FeS/SAM binding site; other site 585395010216 HemN C-terminal domain; Region: HemN_C; pfam06969 585395010217 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585395010218 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 585395010219 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 585395010220 DctM-like transporters; Region: DctM; pfam06808 585395010221 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 585395010222 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 585395010223 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 585395010224 homodimer interface [polypeptide binding]; other site 585395010225 active site 585395010226 hypothetical protein; Provisional; Region: PRK10626 585395010227 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 585395010228 hypothetical protein; Provisional; Region: PRK11702 585395010229 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 585395010230 adenine DNA glycosylase; Provisional; Region: PRK10880 585395010231 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585395010232 minor groove reading motif; other site 585395010233 helix-hairpin-helix signature motif; other site 585395010234 substrate binding pocket [chemical binding]; other site 585395010235 active site 585395010236 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 585395010237 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 585395010238 DNA binding and oxoG recognition site [nucleotide binding] 585395010239 oxidative damage protection protein; Provisional; Region: PRK05408 585395010240 murein transglycosylase C; Provisional; Region: mltC; PRK11671 585395010241 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 585395010242 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585395010243 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585395010244 catalytic residue [active] 585395010245 nucleoside transporter; Region: 2A0110; TIGR00889 585395010246 ornithine decarboxylase; Provisional; Region: PRK13578 585395010247 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585395010248 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585395010249 homodimer interface [polypeptide binding]; other site 585395010250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395010251 catalytic residue [active] 585395010252 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585395010253 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 585395010254 Integrative element ECO103_IE03, LEE 585395010255 integrase; Provisional; Region: PRK09692 585395010256 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585395010257 active site 585395010258 Int/Topo IB signature motif; other site 585395010259 Integrative element ECO103_IE03; predicted protein Orf3 in insertion sequence ISEc8, C-terminal fragment 585395010260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 585395010261 Homeodomain-like domain; Region: HTH_23; pfam13384 585395010262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395010263 Transposase; Region: HTH_Tnp_1; pfam01527 585395010264 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585395010265 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585395010266 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585395010267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585395010268 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585395010269 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585395010270 Integrative element ECO103_IE03; predicted helicase 585395010271 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585395010272 Integrative element ECO103_IE03; predicted protein, N-terminal fragment 585395010273 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 585395010274 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 585395010275 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 585395010276 type III secretion system protein; Provisional; Region: PRK15384; cl14665 585395010277 Integrative element ECO103_IE03; predicted transposase of insertion sequence IS630, partial 585395010278 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 585395010279 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 585395010280 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 585395010281 cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586 585395010282 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 585395010283 Integrative element ECO103_IE03; predicted transposase of insertion sequence IS604, N-terminal fragment 585395010284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395010285 Transposase; Region: HTH_Tnp_1; pfam01527 585395010286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585395010287 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585395010288 Integrative element ECO103_IE03; transposase OrfB protein of insertion sequence IS629, C-terminal fragment 585395010289 Integrative element ECO103_IE03; predicted protein Orf3 in insertion sequence IS682, C-terminal fragment 585395010290 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585395010291 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585395010292 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585395010293 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585395010294 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 585395010295 Haemolysin expression modulating protein; Region: HHA; cl11501 585395010296 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 585395010297 Integrative element ECO103_IE03; transposase OrfA protein of insertion sequence IS629, C-terminal disrupted 585395010298 Integrative element ECO103_IE03; transposase OrfB protein of insertion sequence IS629, C-terminal fragment 585395010299 Predicted GTPase [General function prediction only]; Region: COG3596 585395010300 YfjP GTPase; Region: YfjP; cd11383 585395010301 G1 box; other site 585395010302 GTP/Mg2+ binding site [chemical binding]; other site 585395010303 Switch I region; other site 585395010304 G2 box; other site 585395010305 Switch II region; other site 585395010306 G3 box; other site 585395010307 G4 box; other site 585395010308 G5 box; other site 585395010309 Integrative element ECO103_IE03; AidA-I adhesin-like protein, N-terminal fragment 585395010310 Transposase; Region: HTH_Tnp_1; cl17663 585395010311 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395010312 putative transposase OrfB; Reviewed; Region: PHA02517 585395010313 HTH-like domain; Region: HTH_21; pfam13276 585395010314 Integrase core domain; Region: rve; pfam00665 585395010315 Integrase core domain; Region: rve_3; pfam13683 585395010316 Integrative element ECO103_IE03; AidA-I adhesin-like protein, C-terminal fragment 585395010317 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585395010318 Antirestriction protein; Region: Antirestrict; pfam03230 585395010319 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585395010320 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585395010321 MPN+ (JAMM) motif; other site 585395010322 Zinc-binding site [ion binding]; other site 585395010323 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585395010324 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585395010325 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 585395010326 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 585395010327 Methyltransferase domain; Region: Methyltransf_27; pfam13708 585395010328 type III secretion protein GogB; Provisional; Region: PRK15386 585395010329 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585395010330 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 585395010331 type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498 585395010332 type III secretion apparatus needle protein; Region: III_needle; TIGR02105 585395010333 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 585395010334 Enterobacterial EspB protein; Region: EspB; pfam05802 585395010335 Uncharacterized conserved protein [Function unknown]; Region: COG5613 585395010336 EspA-like secreted protein; Region: EspA; pfam03433 585395010337 HrpJ-like domain; Region: HrpJ; cl15454 585395010338 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 585395010339 type III secretion system protein SsaD; Provisional; Region: PRK15367 585395010340 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 585395010341 LysM domain; Region: LysM; pfam01476 585395010342 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585395010343 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 585395010344 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585395010345 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585395010346 Intimin C-type lectin domain; Region: Intimin_C; pfam07979 585395010347 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 585395010348 Translocated intimin receptor (Tir) N-terminus; Region: Tir_receptor_N; pfam07490 585395010349 Translocated intimin receptor (Tir) intimin-binding domain; Region: Tir_receptor_M; pfam03549 585395010350 Translocated intimin receptor (Tir) C-terminus; Region: Tir_receptor_C; pfam07489 585395010351 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 585395010352 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 585395010353 SepQ protein; Region: SepQ; pfam06622 585395010354 Protein of unknown function (DUF1106); Region: DUF1106; pfam06523 585395010355 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 585395010356 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 585395010357 Walker A motif; other site 585395010358 ATP binding site [chemical binding]; other site 585395010359 Walker B motif; other site 585395010360 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 585395010361 FHIPEP family; Region: FHIPEP; pfam00771 585395010362 SepZ; Region: SepZ; pfam06066 585395010363 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 585395010364 outer membrane secretin SsaC; Provisional; Region: PRK15346 585395010365 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585395010366 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 585395010367 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 585395010368 Tetratricopeptide repeat; Region: TPR_3; pfam07720 585395010369 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 585395010370 negative regulator GrlR; Provisional; Region: PRK14051 585395010371 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 585395010372 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585395010373 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585395010374 catalytic residue [active] 585395010375 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 585395010376 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 585395010377 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 585395010378 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 585395010379 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 585395010380 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 585395010381 Type III secretion system filament chaperone CesA; Region: CesA; pfam11439 585395010382 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 585395010383 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 585395010384 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585395010385 EspG protein; Region: EspG; pfam06872 585395010386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 585395010387 SdiA-regulated; Region: SdiA-regulated; cd09971 585395010388 putative active site [active] 585395010389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395010390 Transposase; Region: HTH_Tnp_1; cl17663 585395010391 HTH-like domain; Region: HTH_21; pfam13276 585395010392 Integrase core domain; Region: rve; pfam00665 585395010393 DDE domain; Region: DDE_Tnp_IS240; pfam13610 585395010394 Integrase core domain; Region: rve_3; pfam13683 585395010395 conserved predicted inner membrane lipoprotein, C-terminal part 585395010396 putative transposase OrfB; Reviewed; Region: PHA02517 585395010397 HTH-like domain; Region: HTH_21; pfam13276 585395010398 Integrase core domain; Region: rve; pfam00665 585395010399 Integrase core domain; Region: rve_3; pfam13683 585395010400 Transposase; Region: HTH_Tnp_1; cl17663 585395010401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395010402 conserved predicted inner membrane lipoprotein, middle part 585395010403 Transposase; Region: HTH_Tnp_1; cl17663 585395010404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395010405 putative transposase OrfB; Reviewed; Region: PHA02517 585395010406 HTH-like domain; Region: HTH_21; pfam13276 585395010407 Integrase core domain; Region: rve; pfam00665 585395010408 Integrase core domain; Region: rve_3; pfam13683 585395010409 conserved predicted inner membrane lipoprotein, N-terminal part 585395010410 glycolate transporter; Provisional; Region: PRK09695 585395010411 L-lactate permease; Region: Lactate_perm; cl00701 585395010412 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 585395010413 active site 585395010414 hypothetical protein; Provisional; Region: PRK09732 585395010415 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 585395010416 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585395010417 Cysteine-rich domain; Region: CCG; pfam02754 585395010418 Cysteine-rich domain; Region: CCG; pfam02754 585395010419 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 585395010420 FAD binding domain; Region: FAD_binding_4; pfam01565 585395010421 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 585395010422 FAD binding domain; Region: FAD_binding_4; pfam01565 585395010423 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 585395010424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395010425 DNA-binding site [nucleotide binding]; DNA binding site 585395010426 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585395010427 acyl-CoA synthetase; Validated; Region: PRK09192 585395010428 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 585395010429 acyl-activating enzyme (AAE) consensus motif; other site 585395010430 active site 585395010431 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585395010432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585395010433 NAD(P) binding site [chemical binding]; other site 585395010434 active site 585395010435 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585395010436 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585395010437 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 585395010438 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585395010439 catalytic residue [active] 585395010440 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 585395010441 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585395010442 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585395010443 Predicted permeases [General function prediction only]; Region: COG0795 585395010444 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 585395010445 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 585395010446 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 585395010447 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 585395010448 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 585395010449 active site 585395010450 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 585395010451 TMP-binding site; other site 585395010452 ATP-binding site [chemical binding]; other site 585395010453 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 585395010454 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 585395010455 TMP-binding site; other site 585395010456 ATP-binding site [chemical binding]; other site 585395010457 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585395010458 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585395010459 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 585395010460 CHAP domain; Region: CHAP; pfam05257 585395010461 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585395010462 putative S-transferase; Provisional; Region: PRK11752 585395010463 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 585395010464 C-terminal domain interface [polypeptide binding]; other site 585395010465 GSH binding site (G-site) [chemical binding]; other site 585395010466 dimer interface [polypeptide binding]; other site 585395010467 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 585395010468 dimer interface [polypeptide binding]; other site 585395010469 N-terminal domain interface [polypeptide binding]; other site 585395010470 active site 585395010471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585395010472 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585395010473 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585395010474 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 585395010475 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 585395010476 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 585395010477 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 585395010478 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 585395010479 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 585395010480 putative substrate-binding site; other site 585395010481 nickel binding site [ion binding]; other site 585395010482 hydrogenase 2 large subunit; Provisional; Region: PRK10467 585395010483 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 585395010484 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 585395010485 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 585395010486 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 585395010487 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585395010488 hydrogenase 2 small subunit; Provisional; Region: PRK10468 585395010489 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585395010490 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 585395010491 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 585395010492 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 585395010493 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585395010494 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585395010495 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585395010496 active site 585395010497 catalytic tetrad [active] 585395010498 hypothetical protein; Provisional; Region: PRK05208 585395010499 oxidoreductase; Provisional; Region: PRK07985 585395010500 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 585395010501 NAD binding site [chemical binding]; other site 585395010502 metal binding site [ion binding]; metal-binding site 585395010503 active site 585395010504 biopolymer transport protein ExbD; Provisional; Region: PRK11267 585395010505 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 585395010506 biopolymer transport protein ExbB; Provisional; Region: PRK10414 585395010507 cystathionine beta-lyase; Provisional; Region: PRK08114 585395010508 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 585395010509 homodimer interface [polypeptide binding]; other site 585395010510 substrate-cofactor binding pocket; other site 585395010511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395010512 catalytic residue [active] 585395010513 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585395010514 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 585395010515 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 585395010516 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585395010517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395010518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395010519 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 585395010520 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 585395010521 dimer interface [polypeptide binding]; other site 585395010522 active site 585395010523 metal binding site [ion binding]; metal-binding site 585395010524 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585395010525 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585395010526 active site 585395010527 catalytic tetrad [active] 585395010528 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 585395010529 putative outer membrane lipoprotein; Provisional; Region: PRK09973 585395010530 hypothetical protein; Provisional; Region: PRK01254 585395010531 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 585395010532 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 585395010533 FtsI repressor; Provisional; Region: PRK10883 585395010534 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 585395010535 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 585395010536 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 585395010537 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 585395010538 putative acyl-acceptor binding pocket; other site 585395010539 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 585395010540 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 585395010541 CAP-like domain; other site 585395010542 active site 585395010543 primary dimer interface [polypeptide binding]; other site 585395010544 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585395010545 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 585395010546 TIGR00156 family protein; Region: TIGR00156 585395010547 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 585395010548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395010549 active site 585395010550 phosphorylation site [posttranslational modification] 585395010551 intermolecular recognition site; other site 585395010552 dimerization interface [polypeptide binding]; other site 585395010553 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395010554 DNA binding site [nucleotide binding] 585395010555 sensor protein QseC; Provisional; Region: PRK10337 585395010556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395010557 dimer interface [polypeptide binding]; other site 585395010558 phosphorylation site [posttranslational modification] 585395010559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395010560 ATP binding site [chemical binding]; other site 585395010561 Mg2+ binding site [ion binding]; other site 585395010562 G-X-G motif; other site 585395010563 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 585395010564 Uncharacterized conserved protein [Function unknown]; Region: COG1359 585395010565 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 585395010566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395010567 ATP binding site [chemical binding]; other site 585395010568 Mg2+ binding site [ion binding]; other site 585395010569 G-X-G motif; other site 585395010570 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 585395010571 anchoring element; other site 585395010572 dimer interface [polypeptide binding]; other site 585395010573 ATP binding site [chemical binding]; other site 585395010574 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 585395010575 active site 585395010576 metal binding site [ion binding]; metal-binding site 585395010577 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 585395010578 esterase YqiA; Provisional; Region: PRK11071 585395010579 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 585395010580 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 585395010581 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585395010582 active site 585395010583 metal binding site [ion binding]; metal-binding site 585395010584 hexamer interface [polypeptide binding]; other site 585395010585 putative dehydrogenase; Provisional; Region: PRK11039 585395010586 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 585395010587 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585395010588 dimer interface [polypeptide binding]; other site 585395010589 ADP-ribose binding site [chemical binding]; other site 585395010590 active site 585395010591 nudix motif; other site 585395010592 metal binding site [ion binding]; metal-binding site 585395010593 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 585395010594 hypothetical protein; Provisional; Region: PRK11653 585395010595 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585395010596 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 585395010597 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 585395010598 putative active site [active] 585395010599 metal binding site [ion binding]; metal-binding site 585395010600 zinc transporter ZupT; Provisional; Region: PRK04201 585395010601 ZIP Zinc transporter; Region: Zip; pfam02535 585395010602 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 585395010603 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 585395010604 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 585395010605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 585395010606 putative fimbrial protein; Provisional; Region: PRK09733 585395010607 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585395010608 PapC N-terminal domain; Region: PapC_N; pfam13954 585395010609 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585395010610 PapC C-terminal domain; Region: PapC_C; pfam13953 585395010611 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585395010612 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585395010613 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585395010614 Fimbrial protein; Region: Fimbrial; pfam00419 585395010615 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 585395010616 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 585395010617 conserved predicted protein, N-terminal fragment 585395010618 putative transposase OrfB; Reviewed; Region: PHA02517 585395010619 HTH-like domain; Region: HTH_21; pfam13276 585395010620 Integrase core domain; Region: rve; pfam00665 585395010621 Integrase core domain; Region: rve_3; pfam13683 585395010622 Transposase; Region: HTH_Tnp_1; cl17663 585395010623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395010624 conserved predicted protein, C-terminal fragment 585395010625 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 585395010626 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 585395010627 putative ribose interaction site [chemical binding]; other site 585395010628 putative ADP binding site [chemical binding]; other site 585395010629 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 585395010630 active site 585395010631 nucleotide binding site [chemical binding]; other site 585395010632 HIGH motif; other site 585395010633 KMSKS motif; other site 585395010634 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 585395010635 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585395010636 metal binding triad; other site 585395010637 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585395010638 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585395010639 metal binding triad; other site 585395010640 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585395010641 Uncharacterized conserved protein [Function unknown]; Region: COG3025 585395010642 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 585395010643 putative active site [active] 585395010644 putative metal binding residues [ion binding]; other site 585395010645 signature motif; other site 585395010646 putative triphosphate binding site [ion binding]; other site 585395010647 CHAD domain; Region: CHAD; pfam05235 585395010648 SH3 domain-containing protein; Provisional; Region: PRK10884 585395010649 Bacterial SH3 domain homologues; Region: SH3b; smart00287 585395010650 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 585395010651 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 585395010652 active site 585395010653 NTP binding site [chemical binding]; other site 585395010654 metal binding triad [ion binding]; metal-binding site 585395010655 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 585395010656 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585395010657 Zn2+ binding site [ion binding]; other site 585395010658 Mg2+ binding site [ion binding]; other site 585395010659 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 585395010660 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 585395010661 homooctamer interface [polypeptide binding]; other site 585395010662 active site 585395010663 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 585395010664 transcriptional activator TtdR; Provisional; Region: PRK09801 585395010665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395010666 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 585395010667 putative effector binding pocket; other site 585395010668 putative dimerization interface [polypeptide binding]; other site 585395010669 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 585395010670 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 585395010671 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585395010672 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585395010673 transmembrane helices; other site 585395010674 UGMP family protein; Validated; Region: PRK09604 585395010675 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 585395010676 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 585395010677 DNA primase; Validated; Region: dnaG; PRK05667 585395010678 CHC2 zinc finger; Region: zf-CHC2; pfam01807 585395010679 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 585395010680 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 585395010681 active site 585395010682 metal binding site [ion binding]; metal-binding site 585395010683 interdomain interaction site; other site 585395010684 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 585395010685 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 585395010686 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 585395010687 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 585395010688 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 585395010689 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 585395010690 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585395010691 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585395010692 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585395010693 DNA binding residues [nucleotide binding] 585395010694 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 585395010695 active site 585395010696 SUMO-1 interface [polypeptide binding]; other site 585395010697 Integrative element ECO103_IE04 585395010698 Methyltransferase domain; Region: Methyltransf_27; pfam13708 585395010699 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 585395010700 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585395010701 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585395010702 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585395010703 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585395010704 MPN+ (JAMM) motif; other site 585395010705 Zinc-binding site [ion binding]; other site 585395010706 Antirestriction protein; Region: Antirestrict; pfam03230 585395010707 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585395010708 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428 585395010709 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 585395010710 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 585395010711 nucleophile elbow; other site 585395010712 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 585395010713 YjcZ-like protein; Region: YjcZ; pfam13990 585395010714 hypothetical protein; Provisional; Region: PRK09866 585395010715 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585395010716 G1 box; other site 585395010717 GTP/Mg2+ binding site [chemical binding]; other site 585395010718 G2 box; other site 585395010719 Switch I region; other site 585395010720 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 585395010721 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585395010722 G3 box; other site 585395010723 Switch II region; other site 585395010724 GTP/Mg2+ binding site [chemical binding]; other site 585395010725 G4 box; other site 585395010726 G5 box; other site 585395010727 Predicted GTPase [General function prediction only]; Region: COG3596 585395010728 YfjP GTPase; Region: YfjP; cd11383 585395010729 G1 box; other site 585395010730 GTP/Mg2+ binding site [chemical binding]; other site 585395010731 Switch I region; other site 585395010732 G2 box; other site 585395010733 Switch II region; other site 585395010734 G3 box; other site 585395010735 G4 box; other site 585395010736 G5 box; other site 585395010737 Integrative element ECO103_IE04; predicted protein Orf1 in insertion sequence IS682, N-terminal fragment 585395010738 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 585395010739 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 585395010740 putative metal binding site [ion binding]; other site 585395010741 Bacterial stress protein; Region: TerD; pfam02342 585395010742 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585395010743 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585395010744 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 585395010745 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 585395010746 putative metal binding site [ion binding]; other site 585395010747 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 585395010748 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 585395010749 putative metal binding site [ion binding]; other site 585395010750 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 585395010751 tellurite resistance protein terB; Region: terB; cd07176 585395010752 putative metal binding site [ion binding]; other site 585395010753 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 585395010754 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 585395010755 putative metal binding site [ion binding]; other site 585395010756 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 585395010757 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 585395010758 putative metal binding site [ion binding]; other site 585395010759 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 585395010760 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 585395010761 putative metal binding site [ion binding]; other site 585395010762 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 585395010763 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585395010764 active site 585395010765 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 585395010766 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 585395010767 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 585395010768 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 585395010769 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 585395010770 Predicted transcriptional regulator [Transcription]; Region: COG2378 585395010771 Integrative element ECO103_IE04; predicted protein, N-terminal fragment 585395010772 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585395010773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585395010774 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585395010775 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585395010776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585395010777 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585395010778 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 585395010779 Integrative element ECO103_IE04; complement resistance protein precursor, C-terminal fragment 585395010780 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 585395010781 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 585395010782 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 585395010783 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585395010784 Sulfatase; Region: Sulfatase; pfam00884 585395010785 Integrative element ECO103_IE04; urease-associated protein UreD, N-terminal fragment 585395010786 Integrative element ECO103_IE04; urease-associated protein UreD, C-terminal fragment 585395010787 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 585395010788 alpha-gamma subunit interface [polypeptide binding]; other site 585395010789 beta-gamma subunit interface [polypeptide binding]; other site 585395010790 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 585395010791 gamma-beta subunit interface [polypeptide binding]; other site 585395010792 alpha-beta subunit interface [polypeptide binding]; other site 585395010793 urease subunit alpha; Reviewed; Region: ureC; PRK13207 585395010794 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 585395010795 subunit interactions [polypeptide binding]; other site 585395010796 active site 585395010797 flap region; other site 585395010798 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 585395010799 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 585395010800 dimer interface [polypeptide binding]; other site 585395010801 catalytic residues [active] 585395010802 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 585395010803 UreF; Region: UreF; pfam01730 585395010804 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585395010805 Integrative element ECO103_IE04; predicted protein Orf3 in insertion sequence IS682, C-terminal fragment 585395010806 Integrative element ECO103_IE04; transposase InsAB' of insertion sequence IS2, C-terminal fragment 585395010807 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 585395010808 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 585395010809 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585395010810 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585395010811 Transposase; Region: HTH_Tnp_1; pfam01527 585395010812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395010813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585395010814 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585395010815 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 585395010816 homodimer interface [polypeptide binding]; other site 585395010817 putative GKAP docking site [polypeptide binding]; other site 585395010818 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585395010819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585395010820 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585395010821 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585395010822 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585395010823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 585395010824 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 585395010825 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395010826 ATP binding site [chemical binding]; other site 585395010827 putative Mg++ binding site [ion binding]; other site 585395010828 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395010829 nucleotide binding region [chemical binding]; other site 585395010830 ATP-binding site [chemical binding]; other site 585395010831 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585395010832 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 585395010833 integrase; Provisional; Region: PRK09692 585395010834 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585395010835 active site 585395010836 DNA binding site [nucleotide binding] 585395010837 Int/Topo IB signature motif; other site 585395010838 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 585395010839 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 585395010840 FAD binding pocket [chemical binding]; other site 585395010841 FAD binding motif [chemical binding]; other site 585395010842 phosphate binding motif [ion binding]; other site 585395010843 NAD binding pocket [chemical binding]; other site 585395010844 Predicted transcriptional regulators [Transcription]; Region: COG1695 585395010845 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 585395010846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585395010847 PAS fold; Region: PAS_3; pfam08447 585395010848 putative active site [active] 585395010849 heme pocket [chemical binding]; other site 585395010850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 585395010851 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 585395010852 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585395010853 dimer interface [polypeptide binding]; other site 585395010854 putative CheW interface [polypeptide binding]; other site 585395010855 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 585395010856 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585395010857 inhibitor-cofactor binding pocket; inhibition site 585395010858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395010859 catalytic residue [active] 585395010860 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 585395010861 dimer interface [polypeptide binding]; other site 585395010862 putative tRNA-binding site [nucleotide binding]; other site 585395010863 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 585395010864 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585395010865 DNA binding site [nucleotide binding] 585395010866 domain linker motif; other site 585395010867 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 585395010868 putative dimerization interface [polypeptide binding]; other site 585395010869 putative ligand binding site [chemical binding]; other site 585395010870 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 585395010871 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 585395010872 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 585395010873 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 585395010874 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 585395010875 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 585395010876 inner membrane transporter YjeM; Provisional; Region: PRK15238 585395010877 alpha-glucosidase; Provisional; Region: PRK10137 585395010878 Protein of unknown function, DUF608; Region: DUF608; pfam04685 585395010879 Trehalase; Region: Trehalase; cl17346 585395010880 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 585395010881 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 585395010882 active site 585395010883 FMN binding site [chemical binding]; other site 585395010884 2,4-decadienoyl-CoA binding site; other site 585395010885 catalytic residue [active] 585395010886 4Fe-4S cluster binding site [ion binding]; other site 585395010887 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 585395010888 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395010889 non-specific DNA binding site [nucleotide binding]; other site 585395010890 salt bridge; other site 585395010891 sequence-specific DNA binding site [nucleotide binding]; other site 585395010892 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 585395010893 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 585395010894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395010895 S-adenosylmethionine binding site [chemical binding]; other site 585395010896 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 585395010897 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585395010898 putative active site [active] 585395010899 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585395010900 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585395010901 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 585395010902 serine/threonine transporter SstT; Provisional; Region: PRK13628 585395010903 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585395010904 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 585395010905 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 585395010906 galactarate dehydratase; Region: galactar-dH20; TIGR03248 585395010907 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 585395010908 Glucuronate isomerase; Region: UxaC; pfam02614 585395010909 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 585395010910 D-galactonate transporter; Region: 2A0114; TIGR00893 585395010911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395010912 putative substrate translocation pore; other site 585395010913 CblD like pilus biogenesis initiator; Region: CblD; cl06460 585395010914 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 585395010915 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585395010916 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 585395010917 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585395010918 putative fimbrial protein TcfA; Provisional; Region: PRK15308 585395010919 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 585395010920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395010921 DNA-binding site [nucleotide binding]; DNA binding site 585395010922 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585395010923 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585395010924 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 585395010925 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 585395010926 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 585395010927 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 585395010928 Predicted membrane protein [Function unknown]; Region: COG5393 585395010929 YqjK-like protein; Region: YqjK; pfam13997 585395010930 Predicted membrane protein [Function unknown]; Region: COG2259 585395010931 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 585395010932 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 585395010933 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 585395010934 putative dimer interface [polypeptide binding]; other site 585395010935 N-terminal domain interface [polypeptide binding]; other site 585395010936 putative substrate binding pocket (H-site) [chemical binding]; other site 585395010937 Predicted membrane protein [Function unknown]; Region: COG3152 585395010938 Protein of unknown function (DUF805); Region: DUF805; pfam05656 585395010939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395010940 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585395010941 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585395010942 dimerization interface [polypeptide binding]; other site 585395010943 Pirin-related protein [General function prediction only]; Region: COG1741 585395010944 Pirin; Region: Pirin; pfam02678 585395010945 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 585395010946 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585395010947 serine transporter; Region: stp; TIGR00814 585395010948 L-serine dehydratase TdcG; Provisional; Region: PRK15040 585395010949 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585395010950 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585395010951 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585395010952 homotrimer interaction site [polypeptide binding]; other site 585395010953 putative active site [active] 585395010954 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 585395010955 Pyruvate formate lyase 1; Region: PFL1; cd01678 585395010956 coenzyme A binding site [chemical binding]; other site 585395010957 active site 585395010958 catalytic residues [active] 585395010959 glycine loop; other site 585395010960 propionate/acetate kinase; Provisional; Region: PRK12379 585395010961 Acetokinase family; Region: Acetate_kinase; cl17229 585395010962 threonine/serine transporter TdcC; Provisional; Region: PRK13629 585395010963 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585395010964 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 585395010965 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 585395010966 tetramer interface [polypeptide binding]; other site 585395010967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395010968 catalytic residue [active] 585395010969 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 585395010970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395010971 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 585395010972 putative substrate binding pocket [chemical binding]; other site 585395010973 putative dimerization interface [polypeptide binding]; other site 585395010974 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 585395010975 hypothetical protein; Provisional; Region: PRK09716 585395010976 glycerate kinase I; Provisional; Region: PRK10342 585395010977 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 585395010978 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585395010979 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 585395010980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395010981 D-galactonate transporter; Region: 2A0114; TIGR00893 585395010982 putative substrate translocation pore; other site 585395010983 galactarate dehydratase; Region: galactar-dH20; TIGR03248 585395010984 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 585395010985 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 585395010986 putative regulator PrlF; Provisional; Region: PRK09974 585395010987 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 585395010988 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 585395010989 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 585395010990 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585395010991 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585395010992 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 585395010993 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585395010994 active site 585395010995 phosphorylation site [posttranslational modification] 585395010996 N-acetylgalactosamine-specific enzyme IIC component of PTS, fragment 585395010997 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 585395010998 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585395010999 active pocket/dimerization site; other site 585395011000 active site 585395011001 phosphorylation site [posttranslational modification] 585395011002 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 585395011003 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 585395011004 active site 585395011005 dimer interface [polypeptide binding]; other site 585395011006 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 585395011007 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 585395011008 dimer interface [polypeptide binding]; other site 585395011009 active site 585395011010 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 585395011011 putative active site [active] 585395011012 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 585395011013 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585395011014 active site 585395011015 intersubunit interface [polypeptide binding]; other site 585395011016 zinc binding site [ion binding]; other site 585395011017 Na+ binding site [ion binding]; other site 585395011018 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585395011019 active site 585395011020 phosphorylation site [posttranslational modification] 585395011021 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 585395011022 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 585395011023 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585395011024 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585395011025 active site 585395011026 trimer interface [polypeptide binding]; other site 585395011027 allosteric site; other site 585395011028 active site lid [active] 585395011029 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585395011030 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585395011031 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585395011032 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585395011033 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585395011034 PapC N-terminal domain; Region: PapC_N; pfam13954 585395011035 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585395011036 PapC C-terminal domain; Region: PapC_C; pfam13953 585395011037 putative transposase OrfB; Reviewed; Region: PHA02517 585395011038 HTH-like domain; Region: HTH_21; pfam13276 585395011039 Integrase core domain; Region: rve; pfam00665 585395011040 Integrase core domain; Region: rve_3; pfam13683 585395011041 Transposase; Region: HTH_Tnp_1; cl17663 585395011042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395011043 Fimbrial protein; Region: Fimbrial; pfam00419 585395011044 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 585395011045 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 585395011046 putative SAM binding site [chemical binding]; other site 585395011047 putative homodimer interface [polypeptide binding]; other site 585395011048 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 585395011049 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 585395011050 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 585395011051 putative ligand binding site [chemical binding]; other site 585395011052 TIGR00252 family protein; Region: TIGR00252 585395011053 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 585395011054 dimer interface [polypeptide binding]; other site 585395011055 active site 585395011056 outer membrane lipoprotein; Provisional; Region: PRK11023 585395011057 BON domain; Region: BON; pfam04972 585395011058 BON domain; Region: BON; pfam04972 585395011059 Predicted permease; Region: DUF318; pfam03773 585395011060 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 585395011061 NADH(P)-binding; Region: NAD_binding_10; pfam13460 585395011062 NAD binding site [chemical binding]; other site 585395011063 active site 585395011064 intracellular protease, PfpI family; Region: PfpI; TIGR01382 585395011065 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 585395011066 proposed catalytic triad [active] 585395011067 conserved cys residue [active] 585395011068 hypothetical protein; Provisional; Region: PRK03467 585395011069 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 585395011070 GIY-YIG motif/motif A; other site 585395011071 putative active site [active] 585395011072 putative metal binding site [ion binding]; other site 585395011073 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 585395011074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395011075 Coenzyme A binding pocket [chemical binding]; other site 585395011076 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 585395011077 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585395011078 Peptidase family U32; Region: Peptidase_U32; pfam01136 585395011079 putative protease; Provisional; Region: PRK15447 585395011080 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585395011081 hypothetical protein; Provisional; Region: PRK10508 585395011082 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 585395011083 tryptophan permease; Provisional; Region: PRK10483 585395011084 aromatic amino acid transport protein; Region: araaP; TIGR00837 585395011085 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 585395011086 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585395011087 ATP binding site [chemical binding]; other site 585395011088 Mg++ binding site [ion binding]; other site 585395011089 motif III; other site 585395011090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395011091 nucleotide binding region [chemical binding]; other site 585395011092 ATP-binding site [chemical binding]; other site 585395011093 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 585395011094 putative RNA binding site [nucleotide binding]; other site 585395011095 lipoprotein NlpI; Provisional; Region: PRK11189 585395011096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585395011097 binding surface 585395011098 TPR motif; other site 585395011099 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 585395011100 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 585395011101 RNase E interface [polypeptide binding]; other site 585395011102 trimer interface [polypeptide binding]; other site 585395011103 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 585395011104 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 585395011105 RNase E interface [polypeptide binding]; other site 585395011106 trimer interface [polypeptide binding]; other site 585395011107 active site 585395011108 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 585395011109 putative nucleic acid binding region [nucleotide binding]; other site 585395011110 G-X-X-G motif; other site 585395011111 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 585395011112 RNA binding site [nucleotide binding]; other site 585395011113 domain interface; other site 585395011114 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 585395011115 16S/18S rRNA binding site [nucleotide binding]; other site 585395011116 S13e-L30e interaction site [polypeptide binding]; other site 585395011117 25S rRNA binding site [nucleotide binding]; other site 585395011118 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 585395011119 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 585395011120 RNA binding site [nucleotide binding]; other site 585395011121 active site 585395011122 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 585395011123 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 585395011124 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 585395011125 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 585395011126 translation initiation factor IF-2; Region: IF-2; TIGR00487 585395011127 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 585395011128 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 585395011129 G1 box; other site 585395011130 putative GEF interaction site [polypeptide binding]; other site 585395011131 GTP/Mg2+ binding site [chemical binding]; other site 585395011132 Switch I region; other site 585395011133 G2 box; other site 585395011134 G3 box; other site 585395011135 Switch II region; other site 585395011136 G4 box; other site 585395011137 G5 box; other site 585395011138 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 585395011139 Translation-initiation factor 2; Region: IF-2; pfam11987 585395011140 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 585395011141 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 585395011142 NusA N-terminal domain; Region: NusA_N; pfam08529 585395011143 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 585395011144 RNA binding site [nucleotide binding]; other site 585395011145 homodimer interface [polypeptide binding]; other site 585395011146 NusA-like KH domain; Region: KH_5; pfam13184 585395011147 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 585395011148 G-X-X-G motif; other site 585395011149 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 585395011150 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 585395011151 ribosome maturation protein RimP; Reviewed; Region: PRK00092 585395011152 hypothetical protein; Provisional; Region: PRK14641 585395011153 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 585395011154 putative oligomer interface [polypeptide binding]; other site 585395011155 putative RNA binding site [nucleotide binding]; other site 585395011156 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 585395011157 ANP binding site [chemical binding]; other site 585395011158 Substrate Binding Site II [chemical binding]; other site 585395011159 Substrate Binding Site I [chemical binding]; other site 585395011160 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 585395011161 Sulfatase; Region: Sulfatase; pfam00884 585395011162 Preprotein translocase SecG subunit; Region: SecG; pfam03840 585395011163 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 585395011164 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 585395011165 active site 585395011166 substrate binding site [chemical binding]; other site 585395011167 metal binding site [ion binding]; metal-binding site 585395011168 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 585395011169 dihydropteroate synthase; Region: DHPS; TIGR01496 585395011170 substrate binding pocket [chemical binding]; other site 585395011171 dimer interface [polypeptide binding]; other site 585395011172 inhibitor binding site; inhibition site 585395011173 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 585395011174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395011175 Walker A motif; other site 585395011176 ATP binding site [chemical binding]; other site 585395011177 Walker B motif; other site 585395011178 arginine finger; other site 585395011179 Peptidase family M41; Region: Peptidase_M41; pfam01434 585395011180 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 585395011181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395011182 S-adenosylmethionine binding site [chemical binding]; other site 585395011183 RNA-binding protein YhbY; Provisional; Region: PRK10343 585395011184 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 585395011185 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 585395011186 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585395011187 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 585395011188 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 585395011189 GTPase CgtA; Reviewed; Region: obgE; PRK12298 585395011190 GTP1/OBG; Region: GTP1_OBG; pfam01018 585395011191 Obg GTPase; Region: Obg; cd01898 585395011192 G1 box; other site 585395011193 GTP/Mg2+ binding site [chemical binding]; other site 585395011194 Switch I region; other site 585395011195 G2 box; other site 585395011196 G3 box; other site 585395011197 Switch II region; other site 585395011198 G4 box; other site 585395011199 G5 box; other site 585395011200 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 585395011201 EamA-like transporter family; Region: EamA; pfam00892 585395011202 EamA-like transporter family; Region: EamA; pfam00892 585395011203 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 585395011204 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 585395011205 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 585395011206 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 585395011207 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 585395011208 substrate binding pocket [chemical binding]; other site 585395011209 chain length determination region; other site 585395011210 substrate-Mg2+ binding site; other site 585395011211 catalytic residues [active] 585395011212 aspartate-rich region 1; other site 585395011213 active site lid residues [active] 585395011214 aspartate-rich region 2; other site 585395011215 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 585395011216 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 585395011217 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 585395011218 hinge; other site 585395011219 active site 585395011220 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 585395011221 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 585395011222 anti sigma factor interaction site; other site 585395011223 regulatory phosphorylation site [posttranslational modification]; other site 585395011224 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 585395011225 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 585395011226 mce related protein; Region: MCE; pfam02470 585395011227 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 585395011228 conserved hypothetical integral membrane protein; Region: TIGR00056 585395011229 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 585395011230 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 585395011231 Walker A/P-loop; other site 585395011232 ATP binding site [chemical binding]; other site 585395011233 Q-loop/lid; other site 585395011234 ABC transporter signature motif; other site 585395011235 Walker B; other site 585395011236 D-loop; other site 585395011237 H-loop/switch region; other site 585395011238 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 585395011239 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585395011240 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585395011241 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 585395011242 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 585395011243 putative active site [active] 585395011244 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 585395011245 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 585395011246 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 585395011247 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 585395011248 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 585395011249 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 585395011250 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 585395011251 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 585395011252 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 585395011253 Walker A/P-loop; other site 585395011254 ATP binding site [chemical binding]; other site 585395011255 Q-loop/lid; other site 585395011256 ABC transporter signature motif; other site 585395011257 Walker B; other site 585395011258 D-loop; other site 585395011259 H-loop/switch region; other site 585395011260 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 585395011261 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 585395011262 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 585395011263 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 585395011264 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 585395011265 30S subunit binding site; other site 585395011266 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585395011267 active site 585395011268 phosphorylation site [posttranslational modification] 585395011269 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 585395011270 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585395011271 dimerization domain swap beta strand [polypeptide binding]; other site 585395011272 regulatory protein interface [polypeptide binding]; other site 585395011273 active site 585395011274 regulatory phosphorylation site [posttranslational modification]; other site 585395011275 hypothetical protein; Provisional; Region: PRK10345 585395011276 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 585395011277 Transglycosylase; Region: Transgly; cl17702 585395011278 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 585395011279 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 585395011280 conserved cys residue [active] 585395011281 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 585395011282 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585395011283 putative active site [active] 585395011284 heme pocket [chemical binding]; other site 585395011285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395011286 dimer interface [polypeptide binding]; other site 585395011287 phosphorylation site [posttranslational modification] 585395011288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395011289 ATP binding site [chemical binding]; other site 585395011290 Mg2+ binding site [ion binding]; other site 585395011291 G-X-G motif; other site 585395011292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395011293 active site 585395011294 phosphorylation site [posttranslational modification] 585395011295 intermolecular recognition site; other site 585395011296 dimerization interface [polypeptide binding]; other site 585395011297 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585395011298 putative binding surface; other site 585395011299 active site 585395011300 radical SAM protein, TIGR01212 family; Region: TIGR01212 585395011301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395011302 FeS/SAM binding site; other site 585395011303 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 585395011304 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 585395011305 active site 585395011306 dimer interface [polypeptide binding]; other site 585395011307 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 585395011308 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 585395011309 active site 585395011310 FMN binding site [chemical binding]; other site 585395011311 substrate binding site [chemical binding]; other site 585395011312 3Fe-4S cluster binding site [ion binding]; other site 585395011313 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 585395011314 domain interface; other site 585395011315 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 585395011316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585395011317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395011318 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 585395011319 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 585395011320 Domain of unknown function (DUF386); Region: DUF386; cl01047 585395011321 N-acetylmannosamine kinase; Provisional; Region: PRK05082 585395011322 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585395011323 nucleotide binding site [chemical binding]; other site 585395011324 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585395011325 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 585395011326 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 585395011327 putative active site cavity [active] 585395011328 putative sialic acid transporter; Provisional; Region: PRK03893 585395011329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395011330 putative substrate translocation pore; other site 585395011331 N-acetylneuraminate lyase; Region: nanA; TIGR00683 585395011332 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 585395011333 inhibitor site; inhibition site 585395011334 active site 585395011335 dimer interface [polypeptide binding]; other site 585395011336 catalytic residue [active] 585395011337 transcriptional regulator NanR; Provisional; Region: PRK03837 585395011338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395011339 DNA-binding site [nucleotide binding]; DNA binding site 585395011340 FCD domain; Region: FCD; pfam07729 585395011341 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 585395011342 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 585395011343 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 585395011344 stringent starvation protein A; Provisional; Region: sspA; PRK09481 585395011345 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 585395011346 C-terminal domain interface [polypeptide binding]; other site 585395011347 putative GSH binding site (G-site) [chemical binding]; other site 585395011348 dimer interface [polypeptide binding]; other site 585395011349 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 585395011350 dimer interface [polypeptide binding]; other site 585395011351 N-terminal domain interface [polypeptide binding]; other site 585395011352 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 585395011353 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 585395011354 23S rRNA interface [nucleotide binding]; other site 585395011355 L3 interface [polypeptide binding]; other site 585395011356 Predicted ATPase [General function prediction only]; Region: COG1485 585395011357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 585395011358 hypothetical protein; Provisional; Region: PRK11677 585395011359 serine endoprotease; Provisional; Region: PRK10139 585395011360 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585395011361 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585395011362 protein binding site [polypeptide binding]; other site 585395011363 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585395011364 serine endoprotease; Provisional; Region: PRK10898 585395011365 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585395011366 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585395011367 malate dehydrogenase; Provisional; Region: PRK05086 585395011368 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 585395011369 NAD binding site [chemical binding]; other site 585395011370 dimerization interface [polypeptide binding]; other site 585395011371 Substrate binding site [chemical binding]; other site 585395011372 arginine repressor; Provisional; Region: PRK05066 585395011373 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 585395011374 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 585395011375 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585395011376 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 585395011377 RNAase interaction site [polypeptide binding]; other site 585395011378 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 585395011379 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585395011380 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 585395011381 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395011382 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395011383 efflux system membrane protein; Provisional; Region: PRK11594 585395011384 transcriptional regulator; Provisional; Region: PRK10632 585395011385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395011386 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 585395011387 putative effector binding pocket; other site 585395011388 dimerization interface [polypeptide binding]; other site 585395011389 protease TldD; Provisional; Region: tldD; PRK10735 585395011390 hypothetical protein; Provisional; Region: PRK10899 585395011391 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585395011392 ribonuclease G; Provisional; Region: PRK11712 585395011393 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 585395011394 homodimer interface [polypeptide binding]; other site 585395011395 oligonucleotide binding site [chemical binding]; other site 585395011396 Maf-like protein; Region: Maf; pfam02545 585395011397 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 585395011398 active site 585395011399 dimer interface [polypeptide binding]; other site 585395011400 rod shape-determining protein MreD; Provisional; Region: PRK11060 585395011401 rod shape-determining protein MreC; Region: mreC; TIGR00219 585395011402 rod shape-determining protein MreC; Region: MreC; pfam04085 585395011403 rod shape-determining protein MreB; Provisional; Region: PRK13927 585395011404 MreB and similar proteins; Region: MreB_like; cd10225 585395011405 nucleotide binding site [chemical binding]; other site 585395011406 Mg binding site [ion binding]; other site 585395011407 putative protofilament interaction site [polypeptide binding]; other site 585395011408 RodZ interaction site [polypeptide binding]; other site 585395011409 regulatory protein CsrD; Provisional; Region: PRK11059 585395011410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395011411 metal binding site [ion binding]; metal-binding site 585395011412 active site 585395011413 I-site; other site 585395011414 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395011415 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 585395011416 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 585395011417 NADP binding site [chemical binding]; other site 585395011418 dimer interface [polypeptide binding]; other site 585395011419 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 585395011420 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 585395011421 carboxyltransferase (CT) interaction site; other site 585395011422 biotinylation site [posttranslational modification]; other site 585395011423 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 585395011424 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585395011425 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 585395011426 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 585395011427 hypothetical protein; Provisional; Region: PRK10633 585395011428 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 585395011429 Na binding site [ion binding]; other site 585395011430 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 585395011431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 585395011432 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 585395011433 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585395011434 FMN binding site [chemical binding]; other site 585395011435 active site 585395011436 catalytic residues [active] 585395011437 substrate binding site [chemical binding]; other site 585395011438 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 585395011439 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 585395011440 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585395011441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395011442 DNA methylase; Region: N6_N4_Mtase; pfam01555 585395011443 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 585395011444 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 585395011445 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585395011446 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 585395011447 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 585395011448 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395011449 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395011450 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 585395011451 Protein export membrane protein; Region: SecD_SecF; cl14618 585395011452 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 585395011453 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 585395011454 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395011455 substrate binding pocket [chemical binding]; other site 585395011456 membrane-bound complex binding site; other site 585395011457 hinge residues; other site 585395011458 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 585395011459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395011460 conserved gate region; other site 585395011461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395011462 dimer interface [polypeptide binding]; other site 585395011463 conserved gate region; other site 585395011464 putative PBP binding loops; other site 585395011465 ABC-ATPase subunit interface; other site 585395011466 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585395011467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395011468 dimer interface [polypeptide binding]; other site 585395011469 conserved gate region; other site 585395011470 putative PBP binding loops; other site 585395011471 ABC-ATPase subunit interface; other site 585395011472 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 585395011473 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585395011474 Walker A/P-loop; other site 585395011475 ATP binding site [chemical binding]; other site 585395011476 Q-loop/lid; other site 585395011477 ABC transporter signature motif; other site 585395011478 Walker B; other site 585395011479 D-loop; other site 585395011480 H-loop/switch region; other site 585395011481 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 585395011482 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 585395011483 trimer interface [polypeptide binding]; other site 585395011484 putative metal binding site [ion binding]; other site 585395011485 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 585395011486 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 585395011487 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 585395011488 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 585395011489 shikimate binding site; other site 585395011490 NAD(P) binding site [chemical binding]; other site 585395011491 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 585395011492 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585395011493 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 585395011494 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585395011495 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585395011496 hypothetical protein; Validated; Region: PRK03430 585395011497 hypothetical protein; Provisional; Region: PRK10736 585395011498 DNA protecting protein DprA; Region: dprA; TIGR00732 585395011499 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 585395011500 active site 585395011501 catalytic residues [active] 585395011502 metal binding site [ion binding]; metal-binding site 585395011503 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 585395011504 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 585395011505 putative active site [active] 585395011506 substrate binding site [chemical binding]; other site 585395011507 putative cosubstrate binding site; other site 585395011508 catalytic site [active] 585395011509 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 585395011510 substrate binding site [chemical binding]; other site 585395011511 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 585395011512 putative RNA binding site [nucleotide binding]; other site 585395011513 16S rRNA methyltransferase B; Provisional; Region: PRK10901 585395011514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395011515 S-adenosylmethionine binding site [chemical binding]; other site 585395011516 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 585395011517 TrkA-N domain; Region: TrkA_N; pfam02254 585395011518 TrkA-C domain; Region: TrkA_C; pfam02080 585395011519 TrkA-N domain; Region: TrkA_N; pfam02254 585395011520 TrkA-C domain; Region: TrkA_C; pfam02080 585395011521 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 585395011522 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 585395011523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 585395011524 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 585395011525 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 585395011526 DNA binding residues [nucleotide binding] 585395011527 dimer interface [polypeptide binding]; other site 585395011528 metal binding site [ion binding]; metal-binding site 585395011529 hypothetical protein; Provisional; Region: PRK10203 585395011530 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 585395011531 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 585395011532 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 585395011533 alphaNTD homodimer interface [polypeptide binding]; other site 585395011534 alphaNTD - beta interaction site [polypeptide binding]; other site 585395011535 alphaNTD - beta' interaction site [polypeptide binding]; other site 585395011536 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 585395011537 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 585395011538 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 585395011539 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585395011540 RNA binding surface [nucleotide binding]; other site 585395011541 30S ribosomal protein S11; Validated; Region: PRK05309 585395011542 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 585395011543 30S ribosomal protein S13; Region: bact_S13; TIGR03631 585395011544 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 585395011545 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 585395011546 SecY translocase; Region: SecY; pfam00344 585395011547 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 585395011548 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 585395011549 23S rRNA binding site [nucleotide binding]; other site 585395011550 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 585395011551 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 585395011552 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 585395011553 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 585395011554 23S rRNA interface [nucleotide binding]; other site 585395011555 5S rRNA interface [nucleotide binding]; other site 585395011556 L27 interface [polypeptide binding]; other site 585395011557 L5 interface [polypeptide binding]; other site 585395011558 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 585395011559 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 585395011560 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 585395011561 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 585395011562 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 585395011563 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 585395011564 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 585395011565 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 585395011566 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 585395011567 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 585395011568 RNA binding site [nucleotide binding]; other site 585395011569 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 585395011570 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 585395011571 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 585395011572 23S rRNA interface [nucleotide binding]; other site 585395011573 putative translocon interaction site; other site 585395011574 signal recognition particle (SRP54) interaction site; other site 585395011575 L23 interface [polypeptide binding]; other site 585395011576 trigger factor interaction site; other site 585395011577 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 585395011578 23S rRNA interface [nucleotide binding]; other site 585395011579 5S rRNA interface [nucleotide binding]; other site 585395011580 putative antibiotic binding site [chemical binding]; other site 585395011581 L25 interface [polypeptide binding]; other site 585395011582 L27 interface [polypeptide binding]; other site 585395011583 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 585395011584 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 585395011585 G-X-X-G motif; other site 585395011586 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 585395011587 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 585395011588 protein-rRNA interface [nucleotide binding]; other site 585395011589 putative translocon binding site; other site 585395011590 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 585395011591 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 585395011592 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 585395011593 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 585395011594 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 585395011595 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 585395011596 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 585395011597 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 585395011598 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 585395011599 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 585395011600 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 585395011601 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 585395011602 heme binding site [chemical binding]; other site 585395011603 ferroxidase pore; other site 585395011604 ferroxidase diiron center [ion binding]; other site 585395011605 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 585395011606 elongation factor Tu; Reviewed; Region: PRK00049 585395011607 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 585395011608 G1 box; other site 585395011609 GEF interaction site [polypeptide binding]; other site 585395011610 GTP/Mg2+ binding site [chemical binding]; other site 585395011611 Switch I region; other site 585395011612 G2 box; other site 585395011613 G3 box; other site 585395011614 Switch II region; other site 585395011615 G4 box; other site 585395011616 G5 box; other site 585395011617 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 585395011618 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 585395011619 Antibiotic Binding Site [chemical binding]; other site 585395011620 elongation factor G; Reviewed; Region: PRK00007 585395011621 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 585395011622 G1 box; other site 585395011623 putative GEF interaction site [polypeptide binding]; other site 585395011624 GTP/Mg2+ binding site [chemical binding]; other site 585395011625 Switch I region; other site 585395011626 G2 box; other site 585395011627 G3 box; other site 585395011628 Switch II region; other site 585395011629 G4 box; other site 585395011630 G5 box; other site 585395011631 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 585395011632 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 585395011633 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 585395011634 30S ribosomal protein S7; Validated; Region: PRK05302 585395011635 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 585395011636 S17 interaction site [polypeptide binding]; other site 585395011637 S8 interaction site; other site 585395011638 16S rRNA interaction site [nucleotide binding]; other site 585395011639 streptomycin interaction site [chemical binding]; other site 585395011640 23S rRNA interaction site [nucleotide binding]; other site 585395011641 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 585395011642 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 585395011643 sulfur relay protein TusC; Validated; Region: PRK00211 585395011644 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 585395011645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 585395011646 YheO-like PAS domain; Region: PAS_6; pfam08348 585395011647 HTH domain; Region: HTH_22; pfam13309 585395011648 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 585395011649 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 585395011650 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585395011651 phi X174 lysis protein; Provisional; Region: PRK02793 585395011652 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 585395011653 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585395011654 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 585395011655 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 585395011656 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 585395011657 TrkA-N domain; Region: TrkA_N; pfam02254 585395011658 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 585395011659 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 585395011660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395011661 Walker A/P-loop; other site 585395011662 ATP binding site [chemical binding]; other site 585395011663 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585395011664 ABC transporter signature motif; other site 585395011665 Walker B; other site 585395011666 D-loop; other site 585395011667 ABC transporter; Region: ABC_tran_2; pfam12848 585395011668 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585395011669 putative hydrolase; Provisional; Region: PRK10985 585395011670 hypothetical protein; Provisional; Region: PRK04966 585395011671 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 585395011672 active site 585395011673 hypothetical protein; Provisional; Region: PRK10738 585395011674 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 585395011675 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585395011676 ligand binding site [chemical binding]; other site 585395011677 flexible hinge region; other site 585395011678 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 585395011679 putative switch regulator; other site 585395011680 non-specific DNA interactions [nucleotide binding]; other site 585395011681 DNA binding site [nucleotide binding] 585395011682 sequence specific DNA binding site [nucleotide binding]; other site 585395011683 putative cAMP binding site [chemical binding]; other site 585395011684 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 585395011685 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 585395011686 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585395011687 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 585395011688 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585395011689 inhibitor-cofactor binding pocket; inhibition site 585395011690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395011691 catalytic residue [active] 585395011692 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 585395011693 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 585395011694 glutamine binding [chemical binding]; other site 585395011695 catalytic triad [active] 585395011696 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 585395011697 cell filamentation protein Fic; Provisional; Region: PRK10347 585395011698 hypothetical protein; Provisional; Region: PRK10204 585395011699 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 585395011700 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 585395011701 substrate binding site [chemical binding]; other site 585395011702 putative transporter; Provisional; Region: PRK03699 585395011703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395011704 putative substrate translocation pore; other site 585395011705 nitrite reductase subunit NirD; Provisional; Region: PRK14989 585395011706 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395011707 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585395011708 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585395011709 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585395011710 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 585395011711 nitrite transporter NirC; Provisional; Region: PRK11562 585395011712 siroheme synthase; Provisional; Region: cysG; PRK10637 585395011713 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 585395011714 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 585395011715 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 585395011716 active site 585395011717 SAM binding site [chemical binding]; other site 585395011718 homodimer interface [polypeptide binding]; other site 585395011719 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 585395011720 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 585395011721 hypothetical protein; Provisional; Region: PHA02764 585395011722 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 585395011723 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 585395011724 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 585395011725 dimer interface [polypeptide binding]; other site 585395011726 active site 585395011727 fructoselysine 3-epimerase; Provisional; Region: PRK09856 585395011728 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 585395011729 AP (apurinic/apyrimidinic) site pocket; other site 585395011730 DNA interaction; other site 585395011731 Metal-binding active site; metal-binding site 585395011732 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 585395011733 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585395011734 substrate binding site [chemical binding]; other site 585395011735 ATP binding site [chemical binding]; other site 585395011736 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 585395011737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395011738 DNA-binding site [nucleotide binding]; DNA binding site 585395011739 UTRA domain; Region: UTRA; pfam07702 585395011740 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585395011741 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 585395011742 Protein of unknown function; Region: YhfT; pfam10797 585395011743 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 585395011744 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 585395011745 active site 585395011746 substrate binding pocket [chemical binding]; other site 585395011747 homodimer interaction site [polypeptide binding]; other site 585395011748 putative mutase; Provisional; Region: PRK12383 585395011749 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 585395011750 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 585395011751 dimer interface [polypeptide binding]; other site 585395011752 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 585395011753 active site 585395011754 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585395011755 substrate binding site [chemical binding]; other site 585395011756 catalytic residue [active] 585395011757 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 585395011758 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 585395011759 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 585395011760 active site 585395011761 HIGH motif; other site 585395011762 dimer interface [polypeptide binding]; other site 585395011763 KMSKS motif; other site 585395011764 phosphoglycolate phosphatase; Provisional; Region: PRK13222 585395011765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395011766 motif II; other site 585395011767 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 585395011768 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 585395011769 substrate binding site [chemical binding]; other site 585395011770 hexamer interface [polypeptide binding]; other site 585395011771 metal binding site [ion binding]; metal-binding site 585395011772 DNA adenine methylase; Provisional; Region: PRK10904 585395011773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 585395011774 cell division protein DamX; Validated; Region: PRK10905 585395011775 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 585395011776 active site 585395011777 dimer interface [polypeptide binding]; other site 585395011778 metal binding site [ion binding]; metal-binding site 585395011779 shikimate kinase; Reviewed; Region: aroK; PRK00131 585395011780 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 585395011781 ADP binding site [chemical binding]; other site 585395011782 magnesium binding site [ion binding]; other site 585395011783 putative shikimate binding site; other site 585395011784 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 585395011785 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585395011786 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 585395011787 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 585395011788 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 585395011789 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 585395011790 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 585395011791 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 585395011792 Transglycosylase; Region: Transgly; pfam00912 585395011793 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585395011794 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 585395011795 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585395011796 ADP-ribose binding site [chemical binding]; other site 585395011797 dimer interface [polypeptide binding]; other site 585395011798 active site 585395011799 nudix motif; other site 585395011800 metal binding site [ion binding]; metal-binding site 585395011801 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 585395011802 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 585395011803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395011804 motif II; other site 585395011805 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585395011806 RNA binding surface [nucleotide binding]; other site 585395011807 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 585395011808 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 585395011809 dimerization interface [polypeptide binding]; other site 585395011810 domain crossover interface; other site 585395011811 redox-dependent activation switch; other site 585395011812 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 585395011813 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 585395011814 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 585395011815 active site 585395011816 substrate-binding site [chemical binding]; other site 585395011817 metal-binding site [ion binding] 585395011818 ATP binding site [chemical binding]; other site 585395011819 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 585395011820 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585395011821 dimerization interface [polypeptide binding]; other site 585395011822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395011823 dimer interface [polypeptide binding]; other site 585395011824 phosphorylation site [posttranslational modification] 585395011825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395011826 ATP binding site [chemical binding]; other site 585395011827 G-X-G motif; other site 585395011828 osmolarity response regulator; Provisional; Region: ompR; PRK09468 585395011829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395011830 active site 585395011831 phosphorylation site [posttranslational modification] 585395011832 intermolecular recognition site; other site 585395011833 dimerization interface [polypeptide binding]; other site 585395011834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395011835 DNA binding site [nucleotide binding] 585395011836 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 585395011837 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 585395011838 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585395011839 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 585395011840 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 585395011841 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 585395011842 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 585395011843 RNA binding site [nucleotide binding]; other site 585395011844 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 585395011845 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 585395011846 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 585395011847 G1 box; other site 585395011848 GTP/Mg2+ binding site [chemical binding]; other site 585395011849 Switch I region; other site 585395011850 G2 box; other site 585395011851 G3 box; other site 585395011852 Switch II region; other site 585395011853 G4 box; other site 585395011854 G5 box; other site 585395011855 Nucleoside recognition; Region: Gate; pfam07670 585395011856 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 585395011857 Nucleoside recognition; Region: Gate; pfam07670 585395011858 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 585395011859 putative transposase; Provisional; Region: PRK09857 585395011860 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585395011861 carboxylesterase BioH; Provisional; Region: PRK10349 585395011862 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 585395011863 DNA utilization protein GntX; Provisional; Region: PRK11595 585395011864 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585395011865 active site 585395011866 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 585395011867 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 585395011868 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 585395011869 high-affinity gluconate transporter; Provisional; Region: PRK14984 585395011870 gluconate transporter; Region: gntP; TIGR00791 585395011871 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 585395011872 4-alpha-glucanotransferase; Region: malQ; TIGR00217 585395011873 maltodextrin phosphorylase; Provisional; Region: PRK14985 585395011874 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 585395011875 homodimer interface [polypeptide binding]; other site 585395011876 active site pocket [active] 585395011877 transcriptional regulator MalT; Provisional; Region: PRK04841 585395011878 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395011879 DNA binding residues [nucleotide binding] 585395011880 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 585395011881 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 585395011882 putative active site [active] 585395011883 conserved predicted protein C-terminal fragment 585395011884 conserved predicted protein C-terminal fragment 585395011885 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 585395011886 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 585395011887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395011888 Walker A motif; other site 585395011889 ATP binding site [chemical binding]; other site 585395011890 Walker B motif; other site 585395011891 arginine finger; other site 585395011892 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 585395011893 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585395011894 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585395011895 intramembrane serine protease GlpG; Provisional; Region: PRK10907 585395011896 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 585395011897 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 585395011898 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 585395011899 active site residue [active] 585395011900 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 585395011901 hypothetical protein; Provisional; Region: PRK09781; cl08057 585395011902 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 585395011903 glycogen phosphorylase; Provisional; Region: PRK14986 585395011904 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 585395011905 homodimer interface [polypeptide binding]; other site 585395011906 active site pocket [active] 585395011907 glycogen synthase; Provisional; Region: glgA; PRK00654 585395011908 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 585395011909 ADP-binding pocket [chemical binding]; other site 585395011910 homodimer interface [polypeptide binding]; other site 585395011911 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 585395011912 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 585395011913 ligand binding site; other site 585395011914 oligomer interface; other site 585395011915 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 585395011916 sulfate 1 binding site; other site 585395011917 glycogen debranching enzyme; Provisional; Region: PRK03705 585395011918 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 585395011919 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 585395011920 active site 585395011921 catalytic site [active] 585395011922 glycogen branching enzyme; Provisional; Region: PRK05402 585395011923 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 585395011924 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 585395011925 active site 585395011926 catalytic site [active] 585395011927 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 585395011928 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 585395011929 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585395011930 putative antibiotic transporter; Provisional; Region: PRK10739 585395011931 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 585395011932 DNA protecting protein DprA; Region: dprA; TIGR00732 585395011933 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 585395011934 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395011935 ATP binding site [chemical binding]; other site 585395011936 putative Mg++ binding site [ion binding]; other site 585395011937 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395011938 nucleotide binding region [chemical binding]; other site 585395011939 ATP-binding site [chemical binding]; other site 585395011940 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585395011941 active site 585395011942 low affinity gluconate transporter; Provisional; Region: PRK10472 585395011943 gluconate transporter; Region: gntP; TIGR00791 585395011944 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 585395011945 ATP-binding site [chemical binding]; other site 585395011946 Gluconate-6-phosphate binding site [chemical binding]; other site 585395011947 Shikimate kinase; Region: SKI; pfam01202 585395011948 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 585395011949 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585395011950 DNA binding site [nucleotide binding] 585395011951 domain linker motif; other site 585395011952 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 585395011953 putative ligand binding site [chemical binding]; other site 585395011954 putative dimerization interface [polypeptide binding]; other site 585395011955 Pirin-related protein [General function prediction only]; Region: COG1741 585395011956 Pirin; Region: Pirin; pfam02678 585395011957 putative oxidoreductase; Provisional; Region: PRK10206 585395011958 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585395011959 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585395011960 putative acetyltransferase YhhY; Provisional; Region: PRK10140 585395011961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395011962 Coenzyme A binding pocket [chemical binding]; other site 585395011963 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 585395011964 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 585395011965 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 585395011966 hypothetical protein; Provisional; Region: PRK10350 585395011967 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 585395011968 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 585395011969 putative active site [active] 585395011970 catalytic site [active] 585395011971 putative metal binding site [ion binding]; other site 585395011972 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 585395011973 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585395011974 Walker A/P-loop; other site 585395011975 ATP binding site [chemical binding]; other site 585395011976 Q-loop/lid; other site 585395011977 ABC transporter signature motif; other site 585395011978 Walker B; other site 585395011979 D-loop; other site 585395011980 H-loop/switch region; other site 585395011981 TOBE domain; Region: TOBE_2; pfam08402 585395011982 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 585395011983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395011984 dimer interface [polypeptide binding]; other site 585395011985 conserved gate region; other site 585395011986 putative PBP binding loops; other site 585395011987 ABC-ATPase subunit interface; other site 585395011988 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 585395011989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395011990 dimer interface [polypeptide binding]; other site 585395011991 conserved gate region; other site 585395011992 putative PBP binding loops; other site 585395011993 ABC-ATPase subunit interface; other site 585395011994 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 585395011995 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 585395011996 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 585395011997 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 585395011998 Walker A/P-loop; other site 585395011999 ATP binding site [chemical binding]; other site 585395012000 Q-loop/lid; other site 585395012001 ABC transporter signature motif; other site 585395012002 Walker B; other site 585395012003 D-loop; other site 585395012004 H-loop/switch region; other site 585395012005 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 585395012006 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 585395012007 Walker A/P-loop; other site 585395012008 ATP binding site [chemical binding]; other site 585395012009 Q-loop/lid; other site 585395012010 ABC transporter signature motif; other site 585395012011 Walker B; other site 585395012012 D-loop; other site 585395012013 H-loop/switch region; other site 585395012014 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 585395012015 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 585395012016 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 585395012017 TM-ABC transporter signature motif; other site 585395012018 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585395012019 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 585395012020 TM-ABC transporter signature motif; other site 585395012021 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 585395012022 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 585395012023 dimerization interface [polypeptide binding]; other site 585395012024 ligand binding site [chemical binding]; other site 585395012025 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 585395012026 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 585395012027 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 585395012028 dimerization interface [polypeptide binding]; other site 585395012029 ligand binding site [chemical binding]; other site 585395012030 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 585395012031 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585395012032 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585395012033 DNA binding residues [nucleotide binding] 585395012034 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 585395012035 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 585395012036 cell division protein FtsE; Provisional; Region: PRK10908 585395012037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395012038 Walker A/P-loop; other site 585395012039 ATP binding site [chemical binding]; other site 585395012040 Q-loop/lid; other site 585395012041 ABC transporter signature motif; other site 585395012042 Walker B; other site 585395012043 D-loop; other site 585395012044 H-loop/switch region; other site 585395012045 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 585395012046 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 585395012047 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 585395012048 P loop; other site 585395012049 GTP binding site [chemical binding]; other site 585395012050 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 585395012051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395012052 S-adenosylmethionine binding site [chemical binding]; other site 585395012053 hypothetical protein; Provisional; Region: PRK10910 585395012054 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 585395012055 Predicted membrane protein [Function unknown]; Region: COG3714 585395012056 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 585395012057 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585395012058 metal-binding site [ion binding] 585395012059 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585395012060 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 585395012061 CPxP motif; other site 585395012062 hypothetical protein; Provisional; Region: PRK11212 585395012063 hypothetical protein; Provisional; Region: PRK11615 585395012064 major facilitator superfamily transporter; Provisional; Region: PRK05122 585395012065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395012066 putative substrate translocation pore; other site 585395012067 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 585395012068 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585395012069 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 585395012070 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 585395012071 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 585395012072 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 585395012073 substrate binding site [chemical binding]; other site 585395012074 nickel transporter permease NikB; Provisional; Region: PRK10352 585395012075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395012076 dimer interface [polypeptide binding]; other site 585395012077 conserved gate region; other site 585395012078 putative PBP binding loops; other site 585395012079 ABC-ATPase subunit interface; other site 585395012080 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 585395012081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395012082 dimer interface [polypeptide binding]; other site 585395012083 conserved gate region; other site 585395012084 putative PBP binding loops; other site 585395012085 ABC-ATPase subunit interface; other site 585395012086 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 585395012087 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395012088 Walker A/P-loop; other site 585395012089 ATP binding site [chemical binding]; other site 585395012090 Q-loop/lid; other site 585395012091 ABC transporter signature motif; other site 585395012092 Walker B; other site 585395012093 D-loop; other site 585395012094 H-loop/switch region; other site 585395012095 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585395012096 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 585395012097 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395012098 Walker A/P-loop; other site 585395012099 ATP binding site [chemical binding]; other site 585395012100 Q-loop/lid; other site 585395012101 ABC transporter signature motif; other site 585395012102 Walker B; other site 585395012103 D-loop; other site 585395012104 H-loop/switch region; other site 585395012105 nickel responsive regulator; Provisional; Region: PRK02967 585395012106 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 585395012107 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585395012108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395012109 DNA-binding site [nucleotide binding]; DNA binding site 585395012110 UTRA domain; Region: UTRA; pfam07702 585395012111 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585395012112 active site 585395012113 phosphorylation site [posttranslational modification] 585395012114 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 585395012115 active site 585395012116 P-loop; other site 585395012117 phosphorylation site [posttranslational modification] 585395012118 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 585395012119 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 585395012120 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 585395012121 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 585395012122 putative N- and C-terminal domain interface [polypeptide binding]; other site 585395012123 putative active site [active] 585395012124 putative MgATP binding site [chemical binding]; other site 585395012125 catalytic site [active] 585395012126 metal binding site [ion binding]; metal-binding site 585395012127 putative carbohydrate binding site [chemical binding]; other site 585395012128 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585395012129 dimerization domain swap beta strand [polypeptide binding]; other site 585395012130 regulatory protein interface [polypeptide binding]; other site 585395012131 active site 585395012132 regulatory phosphorylation site [posttranslational modification]; other site 585395012133 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 585395012134 intersubunit interface [polypeptide binding]; other site 585395012135 active site 585395012136 zinc binding site [ion binding]; other site 585395012137 Na+ binding site [ion binding]; other site 585395012138 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 585395012139 HicB family; Region: HicB; pfam05534 585395012140 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585395012141 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 585395012142 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585395012143 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 585395012144 Walker A/P-loop; other site 585395012145 ATP binding site [chemical binding]; other site 585395012146 Q-loop/lid; other site 585395012147 ABC transporter signature motif; other site 585395012148 Walker B; other site 585395012149 D-loop; other site 585395012150 H-loop/switch region; other site 585395012151 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585395012152 Walker A/P-loop; other site 585395012153 ATP binding site [chemical binding]; other site 585395012154 Q-loop/lid; other site 585395012155 ABC transporter signature motif; other site 585395012156 Walker B; other site 585395012157 D-loop; other site 585395012158 H-loop/switch region; other site 585395012159 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585395012160 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 585395012161 HlyD family secretion protein; Region: HlyD; pfam00529 585395012162 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395012163 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395012164 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 585395012165 conserved predicted protein, C-terminal part 585395012166 conserved predicted protein, middle part 585395012167 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 585395012168 Predicted flavoproteins [General function prediction only]; Region: COG2081 585395012169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585395012170 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585395012171 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585395012172 universal stress protein UspB; Provisional; Region: PRK04960 585395012173 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585395012174 Ligand Binding Site [chemical binding]; other site 585395012175 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 585395012176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395012177 POT family; Region: PTR2; pfam00854 585395012178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395012179 S-adenosylmethionine binding site [chemical binding]; other site 585395012180 oligopeptidase A; Provisional; Region: PRK10911 585395012181 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 585395012182 active site 585395012183 Zn binding site [ion binding]; other site 585395012184 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 585395012185 glutathione reductase; Validated; Region: PRK06116 585395012186 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585395012187 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395012188 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585395012189 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585395012190 dimerization interface [polypeptide binding]; other site 585395012191 putative DNA binding site [nucleotide binding]; other site 585395012192 putative Zn2+ binding site [ion binding]; other site 585395012193 arsenical pump membrane protein; Provisional; Region: PRK15445 585395012194 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 585395012195 transmembrane helices; other site 585395012196 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 585395012197 ArsC family; Region: ArsC; pfam03960 585395012198 catalytic residues [active] 585395012199 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585395012200 dimerization interface [polypeptide binding]; other site 585395012201 putative DNA binding site [nucleotide binding]; other site 585395012202 putative Zn2+ binding site [ion binding]; other site 585395012203 Predicted permeases [General function prediction only]; Region: COG0701 585395012204 conserved predicted protein, N-terminal fragment 585395012205 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 585395012206 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585395012207 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395012208 DNA binding residues [nucleotide binding] 585395012209 dimerization interface [polypeptide binding]; other site 585395012210 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 585395012211 MgtC family; Region: MgtC; pfam02308 585395012212 acid-resistance protein; Provisional; Region: hdeB; PRK11566 585395012213 acid-resistance protein; Provisional; Region: PRK10208 585395012214 acid-resistance membrane protein; Provisional; Region: PRK10209 585395012215 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 585395012216 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 585395012217 pyruvate kinase; Provisional; Region: PRK05826 585395012218 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 585395012219 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395012220 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395012221 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 585395012222 Protein export membrane protein; Region: SecD_SecF; cl14618 585395012223 transcriptional regulator YdeO; Provisional; Region: PRK09940 585395012224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395012225 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 585395012226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395012227 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 585395012228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395012229 catalytic residue [active] 585395012230 Haem-binding domain; Region: Haem_bd; pfam14376 585395012231 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 585395012232 trehalase; Provisional; Region: treF; PRK13270 585395012233 Trehalase; Region: Trehalase; pfam01204 585395012234 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585395012235 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395012236 DNA binding residues [nucleotide binding] 585395012237 dimerization interface [polypeptide binding]; other site 585395012238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585395012239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395012240 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 585395012241 putative effector binding pocket; other site 585395012242 putative dimerization interface [polypeptide binding]; other site 585395012243 inner membrane protein YhjD; Region: TIGR00766 585395012244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395012245 metabolite-proton symporter; Region: 2A0106; TIGR00883 585395012246 putative substrate translocation pore; other site 585395012247 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 585395012248 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585395012249 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395012250 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585395012251 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 585395012252 substrate binding site [chemical binding]; other site 585395012253 ATP binding site [chemical binding]; other site 585395012254 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585395012255 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585395012256 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 585395012257 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585395012258 putative diguanylate cyclase; Provisional; Region: PRK13561 585395012259 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585395012260 metal binding site [ion binding]; metal-binding site 585395012261 active site 585395012262 I-site; other site 585395012263 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395012264 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 585395012265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585395012266 binding surface 585395012267 TPR motif; other site 585395012268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585395012269 binding surface 585395012270 TPR motif; other site 585395012271 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 585395012272 endo-1,4-D-glucanase; Provisional; Region: PRK11097 585395012273 cellulose synthase regulator protein; Provisional; Region: PRK11114 585395012274 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 585395012275 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 585395012276 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 585395012277 DXD motif; other site 585395012278 PilZ domain; Region: PilZ; pfam07238 585395012279 cell division protein; Provisional; Region: PRK10037 585395012280 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 585395012281 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 585395012282 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 585395012283 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 585395012284 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 585395012285 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585395012286 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585395012287 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585395012288 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585395012289 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585395012290 serine transporter; Region: stp; TIGR00814 585395012291 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 585395012292 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395012293 Walker A/P-loop; other site 585395012294 ATP binding site [chemical binding]; other site 585395012295 Q-loop/lid; other site 585395012296 ABC transporter signature motif; other site 585395012297 Walker B; other site 585395012298 D-loop; other site 585395012299 H-loop/switch region; other site 585395012300 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585395012301 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 585395012302 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395012303 Walker A/P-loop; other site 585395012304 ATP binding site [chemical binding]; other site 585395012305 Q-loop/lid; other site 585395012306 ABC transporter signature motif; other site 585395012307 Walker B; other site 585395012308 D-loop; other site 585395012309 H-loop/switch region; other site 585395012310 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585395012311 dipeptide transporter; Provisional; Region: PRK10913 585395012312 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585395012313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395012314 dimer interface [polypeptide binding]; other site 585395012315 conserved gate region; other site 585395012316 putative PBP binding loops; other site 585395012317 ABC-ATPase subunit interface; other site 585395012318 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 585395012319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395012320 dimer interface [polypeptide binding]; other site 585395012321 conserved gate region; other site 585395012322 putative PBP binding loops; other site 585395012323 ABC-ATPase subunit interface; other site 585395012324 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 585395012325 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 585395012326 peptide binding site [polypeptide binding]; other site 585395012327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585395012328 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585395012329 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585395012330 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 585395012331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395012332 non-specific DNA binding site [nucleotide binding]; other site 585395012333 salt bridge; other site 585395012334 sequence-specific DNA binding site [nucleotide binding]; other site 585395012335 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 585395012336 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 585395012337 substrate binding pocket [chemical binding]; other site 585395012338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395012339 Coenzyme A binding pocket [chemical binding]; other site 585395012340 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 585395012341 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 585395012342 putative active site [active] 585395012343 dimerization interface [polypeptide binding]; other site 585395012344 putative tRNAtyr binding site [nucleotide binding]; other site 585395012345 hypothetical protein; Reviewed; Region: PRK01637 585395012346 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 585395012347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395012348 motif II; other site 585395012349 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585395012350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585395012351 putative DNA binding site [nucleotide binding]; other site 585395012352 putative Zn2+ binding site [ion binding]; other site 585395012353 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585395012354 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585395012355 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 585395012356 substrate binding site [chemical binding]; other site 585395012357 ATP binding site [chemical binding]; other site 585395012358 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 585395012359 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585395012360 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 585395012361 catalytic residue [active] 585395012362 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 585395012363 dimerization interface [polypeptide binding]; other site 585395012364 putative active cleft [active] 585395012365 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 585395012366 active site 585395012367 catalytic residues [active] 585395012368 alpha-glucosidase; Provisional; Region: PRK10426 585395012369 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 585395012370 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 585395012371 putative active site [active] 585395012372 putative catalytic site [active] 585395012373 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 585395012374 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 585395012375 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 585395012376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395012377 outer membrane porin L; Provisional; Region: ompL; PRK09980 585395012378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395012379 putative substrate translocation pore; other site 585395012380 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 585395012381 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 585395012382 transcriptional regulator protein; Region: phnR; TIGR03337 585395012383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395012384 DNA-binding site [nucleotide binding]; DNA binding site 585395012385 UTRA domain; Region: UTRA; pfam07702 585395012386 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 585395012387 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 585395012388 G1 box; other site 585395012389 putative GEF interaction site [polypeptide binding]; other site 585395012390 GTP/Mg2+ binding site [chemical binding]; other site 585395012391 Switch I region; other site 585395012392 G2 box; other site 585395012393 G3 box; other site 585395012394 Switch II region; other site 585395012395 G4 box; other site 585395012396 G5 box; other site 585395012397 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 585395012398 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 585395012399 glutamine synthetase; Provisional; Region: glnA; PRK09469 585395012400 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 585395012401 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 585395012402 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 585395012403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585395012404 putative active site [active] 585395012405 heme pocket [chemical binding]; other site 585395012406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395012407 dimer interface [polypeptide binding]; other site 585395012408 phosphorylation site [posttranslational modification] 585395012409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395012410 ATP binding site [chemical binding]; other site 585395012411 Mg2+ binding site [ion binding]; other site 585395012412 G-X-G motif; other site 585395012413 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 585395012414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395012415 active site 585395012416 phosphorylation site [posttranslational modification] 585395012417 intermolecular recognition site; other site 585395012418 dimerization interface [polypeptide binding]; other site 585395012419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395012420 Walker A motif; other site 585395012421 ATP binding site [chemical binding]; other site 585395012422 Walker B motif; other site 585395012423 arginine finger; other site 585395012424 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585395012425 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 585395012426 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395012427 FeS/SAM binding site; other site 585395012428 HemN C-terminal domain; Region: HemN_C; pfam06969 585395012429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 585395012430 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 585395012431 G1 box; other site 585395012432 GTP/Mg2+ binding site [chemical binding]; other site 585395012433 Switch I region; other site 585395012434 G2 box; other site 585395012435 G3 box; other site 585395012436 Switch II region; other site 585395012437 G4 box; other site 585395012438 G5 box; other site 585395012439 DNA polymerase I; Provisional; Region: PRK05755 585395012440 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 585395012441 active site 585395012442 metal binding site 1 [ion binding]; metal-binding site 585395012443 putative 5' ssDNA interaction site; other site 585395012444 metal binding site 3; metal-binding site 585395012445 metal binding site 2 [ion binding]; metal-binding site 585395012446 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 585395012447 putative DNA binding site [nucleotide binding]; other site 585395012448 putative metal binding site [ion binding]; other site 585395012449 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 585395012450 active site 585395012451 catalytic site [active] 585395012452 substrate binding site [chemical binding]; other site 585395012453 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 585395012454 active site 585395012455 DNA binding site [nucleotide binding] 585395012456 catalytic site [active] 585395012457 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 585395012458 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 585395012459 putative acyl-acceptor binding pocket; other site 585395012460 hypothetical protein; Provisional; Region: PRK11367 585395012461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 585395012462 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 585395012463 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 585395012464 catalytic residues [active] 585395012465 hinge region; other site 585395012466 alpha helical domain; other site 585395012467 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 585395012468 serine/threonine protein kinase; Provisional; Region: PRK11768 585395012469 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 585395012470 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 585395012471 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 585395012472 GTP binding site; other site 585395012473 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 585395012474 Walker A motif; other site 585395012475 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 585395012476 potassium transporter; Provisional; Region: PRK10750 585395012477 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 585395012478 hypothetical protein; Provisional; Region: PRK11568 585395012479 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 585395012480 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 585395012481 proline dipeptidase; Provisional; Region: PRK13607 585395012482 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 585395012483 active site 585395012484 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 585395012485 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585395012486 substrate binding site [chemical binding]; other site 585395012487 oxyanion hole (OAH) forming residues; other site 585395012488 trimer interface [polypeptide binding]; other site 585395012489 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585395012490 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585395012491 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585395012492 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 585395012493 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585395012494 dimer interface [polypeptide binding]; other site 585395012495 active site 585395012496 FMN reductase; Validated; Region: fre; PRK08051 585395012497 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 585395012498 FAD binding pocket [chemical binding]; other site 585395012499 FAD binding motif [chemical binding]; other site 585395012500 phosphate binding motif [ion binding]; other site 585395012501 beta-alpha-beta structure motif; other site 585395012502 NAD binding pocket [chemical binding]; other site 585395012503 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 585395012504 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 585395012505 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 585395012506 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 585395012507 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585395012508 active site 585395012509 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 585395012510 sec-independent translocase; Provisional; Region: PRK01770 585395012511 sec-independent translocase; Provisional; Region: tatB; PRK00404 585395012512 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 585395012513 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 585395012514 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 585395012515 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 585395012516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 585395012517 SCP-2 sterol transfer family; Region: SCP2; pfam02036 585395012518 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 585395012519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395012520 S-adenosylmethionine binding site [chemical binding]; other site 585395012521 DNA recombination protein RmuC; Provisional; Region: PRK10361 585395012522 RmuC family; Region: RmuC; pfam02646 585395012523 uridine phosphorylase; Provisional; Region: PRK11178 585395012524 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 585395012525 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 585395012526 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 585395012527 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 585395012528 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 585395012529 THF binding site; other site 585395012530 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 585395012531 substrate binding site [chemical binding]; other site 585395012532 THF binding site; other site 585395012533 zinc-binding site [ion binding]; other site 585395012534 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 585395012535 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395012536 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 585395012537 putative dimerization interface [polypeptide binding]; other site 585395012538 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585395012539 EamA-like transporter family; Region: EamA; pfam00892 585395012540 putative hydrolase; Provisional; Region: PRK10976 585395012541 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395012542 active site 585395012543 motif I; other site 585395012544 motif II; other site 585395012545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395012546 lysophospholipase L2; Provisional; Region: PRK10749 585395012547 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585395012548 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 585395012549 threonine efflux system; Provisional; Region: PRK10229 585395012550 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 585395012551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395012552 ATP binding site [chemical binding]; other site 585395012553 putative Mg++ binding site [ion binding]; other site 585395012554 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395012555 nucleotide binding region [chemical binding]; other site 585395012556 ATP-binding site [chemical binding]; other site 585395012557 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 585395012558 Helicase and RNase D C-terminal; Region: HRDC; smart00341 585395012559 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 585395012560 dimerization interface [polypeptide binding]; other site 585395012561 substrate binding site [chemical binding]; other site 585395012562 active site 585395012563 calcium binding site [ion binding]; other site 585395012564 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585395012565 CoenzymeA binding site [chemical binding]; other site 585395012566 subunit interaction site [polypeptide binding]; other site 585395012567 PHB binding site; other site 585395012568 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 585395012569 EamA-like transporter family; Region: EamA; cl17759 585395012570 predicted magnesium/nickel/cobalt transporter CorA, C-terminal part 585395012571 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 585395012572 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 585395012573 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 585395012574 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 585395012575 Cl binding site [ion binding]; other site 585395012576 oligomer interface [polypeptide binding]; other site 585395012577 Predicted periplasmic protein [Function unknown]; Region: COG3698 585395012578 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 585395012579 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 585395012580 Part of AAA domain; Region: AAA_19; pfam13245 585395012581 Family description; Region: UvrD_C_2; pfam13538 585395012582 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 585395012583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395012584 motif II; other site 585395012585 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 585395012586 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585395012587 active site 585395012588 DNA binding site [nucleotide binding] 585395012589 Int/Topo IB signature motif; other site 585395012590 hypothetical protein; Provisional; Region: PRK10963 585395012591 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 585395012592 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 585395012593 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 585395012594 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 585395012595 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 585395012596 DKNYY family; Region: DKNYY; pfam13644 585395012597 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 585395012598 putative iron binding site [ion binding]; other site 585395012599 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 585395012600 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 585395012601 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 585395012602 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 585395012603 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 585395012604 domain interfaces; other site 585395012605 active site 585395012606 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 585395012607 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 585395012608 active site 585395012609 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 585395012610 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 585395012611 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 585395012612 HemY protein N-terminus; Region: HemY_N; pfam07219 585395012613 acrylsulfatase-like enzyme AslA, N-terminal fragment 585395012614 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 585395012615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395012616 FeS/SAM binding site; other site 585395012617 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 585395012618 putative transport protein YifK; Provisional; Region: PRK10746 585395012619 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 585395012620 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 585395012621 putative common antigen polymerase; Provisional; Region: PRK02975 585395012622 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 585395012623 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 585395012624 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 585395012625 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 585395012626 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 585395012627 inhibitor-cofactor binding pocket; inhibition site 585395012628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395012629 catalytic residue [active] 585395012630 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 585395012631 Coenzyme A binding pocket [chemical binding]; other site 585395012632 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 585395012633 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 585395012634 substrate binding site; other site 585395012635 tetramer interface; other site 585395012636 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 585395012637 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 585395012638 NAD binding site [chemical binding]; other site 585395012639 substrate binding site [chemical binding]; other site 585395012640 homodimer interface [polypeptide binding]; other site 585395012641 active site 585395012642 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 585395012643 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 585395012644 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 585395012645 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 585395012646 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 585395012647 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 585395012648 active site 585395012649 homodimer interface [polypeptide binding]; other site 585395012650 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 585395012651 Chain length determinant protein; Region: Wzz; pfam02706 585395012652 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 585395012653 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 585395012654 Mg++ binding site [ion binding]; other site 585395012655 putative catalytic motif [active] 585395012656 substrate binding site [chemical binding]; other site 585395012657 transcription termination factor Rho; Provisional; Region: rho; PRK09376 585395012658 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 585395012659 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 585395012660 RNA binding site [nucleotide binding]; other site 585395012661 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 585395012662 multimer interface [polypeptide binding]; other site 585395012663 Walker A motif; other site 585395012664 ATP binding site [chemical binding]; other site 585395012665 Walker B motif; other site 585395012666 putative rho operon leader peptide; Provisional; Region: PRK09979 585395012667 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 585395012668 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 585395012669 catalytic residues [active] 585395012670 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 585395012671 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585395012672 ATP binding site [chemical binding]; other site 585395012673 Mg++ binding site [ion binding]; other site 585395012674 motif III; other site 585395012675 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395012676 nucleotide binding region [chemical binding]; other site 585395012677 ATP-binding site [chemical binding]; other site 585395012678 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 585395012679 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 585395012680 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 585395012681 Part of AAA domain; Region: AAA_19; pfam13245 585395012682 Family description; Region: UvrD_C_2; pfam13538 585395012683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 585395012684 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 585395012685 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 585395012686 ketol-acid reductoisomerase; Validated; Region: PRK05225 585395012687 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 585395012688 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 585395012689 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 585395012690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395012691 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 585395012692 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 585395012693 putative dimerization interface [polypeptide binding]; other site 585395012694 threonine dehydratase; Reviewed; Region: PRK09224 585395012695 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 585395012696 tetramer interface [polypeptide binding]; other site 585395012697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395012698 catalytic residue [active] 585395012699 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 585395012700 putative Ile/Val binding site [chemical binding]; other site 585395012701 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 585395012702 putative Ile/Val binding site [chemical binding]; other site 585395012703 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 585395012704 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 585395012705 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 585395012706 homodimer interface [polypeptide binding]; other site 585395012707 substrate-cofactor binding pocket; other site 585395012708 catalytic residue [active] 585395012709 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 585395012710 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 585395012711 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585395012712 PYR/PP interface [polypeptide binding]; other site 585395012713 dimer interface [polypeptide binding]; other site 585395012714 TPP binding site [chemical binding]; other site 585395012715 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585395012716 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585395012717 TPP-binding site [chemical binding]; other site 585395012718 dimer interface [polypeptide binding]; other site 585395012719 ilvG operon leader peptide; Provisional; Region: PRK10424 585395012720 putative ATP-dependent protease; Provisional; Region: PRK09862 585395012721 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 585395012722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395012723 Walker A motif; other site 585395012724 ATP binding site [chemical binding]; other site 585395012725 Walker B motif; other site 585395012726 arginine finger; other site 585395012727 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 585395012728 hypothetical protein; Provisional; Region: PRK11027 585395012729 transcriptional regulator HdfR; Provisional; Region: PRK03601 585395012730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395012731 LysR substrate binding domain; Region: LysR_substrate; pfam03466 585395012732 dimerization interface [polypeptide binding]; other site 585395012733 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585395012734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395012735 DNA-binding site [nucleotide binding]; DNA binding site 585395012736 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585395012737 putative transporter; Provisional; Region: PRK10504 585395012738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395012739 putative substrate translocation pore; other site 585395012740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395012741 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 585395012742 N-terminal part of DNA-binding transcriptional repressor RbsR of ribose metabolism 585395012743 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 585395012744 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585395012745 substrate binding site [chemical binding]; other site 585395012746 dimer interface [polypeptide binding]; other site 585395012747 ATP binding site [chemical binding]; other site 585395012748 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 585395012749 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 585395012750 ligand binding site [chemical binding]; other site 585395012751 dimerization interface [polypeptide binding]; other site 585395012752 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585395012753 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585395012754 TM-ABC transporter signature motif; other site 585395012755 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 585395012756 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585395012757 Walker A/P-loop; other site 585395012758 ATP binding site [chemical binding]; other site 585395012759 Q-loop/lid; other site 585395012760 ABC transporter signature motif; other site 585395012761 Walker B; other site 585395012762 D-loop; other site 585395012763 H-loop/switch region; other site 585395012764 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585395012765 D-ribose pyranase; Provisional; Region: PRK11797 585395012766 C-terminal part of potassium transporter TrkD 585395012767 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 585395012768 potassium uptake protein; Region: kup; TIGR00794 585395012769 regulatory ATPase RavA; Provisional; Region: PRK13531 585395012770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395012771 Walker A motif; other site 585395012772 ATP binding site [chemical binding]; other site 585395012773 Walker B motif; other site 585395012774 arginine finger; other site 585395012775 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 585395012776 hypothetical protein; Provisional; Region: yieM; PRK10997 585395012777 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 585395012778 metal ion-dependent adhesion site (MIDAS); other site 585395012779 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 585395012780 dimer interface [polypeptide binding]; other site 585395012781 active site 585395012782 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 585395012783 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585395012784 putative DNA binding site [nucleotide binding]; other site 585395012785 putative Zn2+ binding site [ion binding]; other site 585395012786 AsnC family; Region: AsnC_trans_reg; pfam01037 585395012787 FMN-binding protein MioC; Provisional; Region: PRK09004 585395012788 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 585395012789 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 585395012790 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 585395012791 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 585395012792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395012793 S-adenosylmethionine binding site [chemical binding]; other site 585395012794 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 585395012795 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 585395012796 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 585395012797 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 585395012798 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 585395012799 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 585395012800 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 585395012801 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 585395012802 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 585395012803 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 585395012804 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 585395012805 beta subunit interaction interface [polypeptide binding]; other site 585395012806 Walker A motif; other site 585395012807 ATP binding site [chemical binding]; other site 585395012808 Walker B motif; other site 585395012809 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 585395012810 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 585395012811 core domain interface [polypeptide binding]; other site 585395012812 delta subunit interface [polypeptide binding]; other site 585395012813 epsilon subunit interface [polypeptide binding]; other site 585395012814 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 585395012815 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 585395012816 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 585395012817 alpha subunit interaction interface [polypeptide binding]; other site 585395012818 Walker A motif; other site 585395012819 ATP binding site [chemical binding]; other site 585395012820 Walker B motif; other site 585395012821 inhibitor binding site; inhibition site 585395012822 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 585395012823 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 585395012824 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 585395012825 gamma subunit interface [polypeptide binding]; other site 585395012826 epsilon subunit interface [polypeptide binding]; other site 585395012827 LBP interface [polypeptide binding]; other site 585395012828 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 585395012829 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 585395012830 Substrate binding site; other site 585395012831 Mg++ binding site; other site 585395012832 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 585395012833 active site 585395012834 substrate binding site [chemical binding]; other site 585395012835 CoA binding site [chemical binding]; other site 585395012836 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 585395012837 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 585395012838 glutaminase active site [active] 585395012839 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 585395012840 dimer interface [polypeptide binding]; other site 585395012841 active site 585395012842 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 585395012843 dimer interface [polypeptide binding]; other site 585395012844 active site 585395012845 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395012846 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 585395012847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395012848 dimer interface [polypeptide binding]; other site 585395012849 conserved gate region; other site 585395012850 putative PBP binding loops; other site 585395012851 ABC-ATPase subunit interface; other site 585395012852 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 585395012853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395012854 dimer interface [polypeptide binding]; other site 585395012855 conserved gate region; other site 585395012856 putative PBP binding loops; other site 585395012857 ABC-ATPase subunit interface; other site 585395012858 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 585395012859 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 585395012860 Walker A/P-loop; other site 585395012861 ATP binding site [chemical binding]; other site 585395012862 Q-loop/lid; other site 585395012863 ABC transporter signature motif; other site 585395012864 Walker B; other site 585395012865 D-loop; other site 585395012866 H-loop/switch region; other site 585395012867 transcriptional regulator PhoU; Provisional; Region: PRK11115 585395012868 PhoU domain; Region: PhoU; pfam01895 585395012869 PhoU domain; Region: PhoU; pfam01895 585395012870 transcriptional antiterminator BglG; Provisional; Region: PRK09772 585395012871 CAT RNA binding domain; Region: CAT_RBD; pfam03123 585395012872 PRD domain; Region: PRD; pfam00874 585395012873 PRD domain; Region: PRD; pfam00874 585395012874 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 585395012875 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585395012876 active site turn [active] 585395012877 phosphorylation site [posttranslational modification] 585395012878 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585395012879 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585395012880 HPr interaction site; other site 585395012881 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585395012882 active site 585395012883 phosphorylation site [posttranslational modification] 585395012884 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 585395012885 beta-galactosidase; Region: BGL; TIGR03356 585395012886 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 585395012887 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585395012888 trimer interface; other site 585395012889 sugar binding site [chemical binding]; other site 585395012890 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 585395012891 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 585395012892 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585395012893 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585395012894 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585395012895 active site 585395012896 trimer interface [polypeptide binding]; other site 585395012897 allosteric site; other site 585395012898 active site lid [active] 585395012899 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 585395012900 putative inner membrane protein; Provisional; Region: PRK09823 585395012901 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 585395012902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395012903 active site 585395012904 motif I; other site 585395012905 motif II; other site 585395012906 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585395012907 Predicted flavoprotein [General function prediction only]; Region: COG0431 585395012908 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585395012909 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 585395012910 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 585395012911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395012912 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 585395012913 substrate binding pocket [chemical binding]; other site 585395012914 dimerization interface [polypeptide binding]; other site 585395012915 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 585395012916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395012917 putative substrate translocation pore; other site 585395012918 tryptophan permease TnaB; Provisional; Region: PRK09664 585395012919 aromatic amino acid transport protein; Region: araaP; TIGR00837 585395012920 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 585395012921 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 585395012922 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585395012923 catalytic residue [active] 585395012924 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 585395012925 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 585395012926 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 585395012927 trmE is a tRNA modification GTPase; Region: trmE; cd04164 585395012928 G1 box; other site 585395012929 GTP/Mg2+ binding site [chemical binding]; other site 585395012930 Switch I region; other site 585395012931 G2 box; other site 585395012932 Switch II region; other site 585395012933 G3 box; other site 585395012934 G4 box; other site 585395012935 G5 box; other site 585395012936 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 585395012937 membrane protein insertase; Provisional; Region: PRK01318 585395012938 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 585395012939 ribonuclease P; Reviewed; Region: rnpA; PRK01732 585395012940 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 585395012941 DnaA N-terminal domain; Region: DnaA_N; pfam11638 585395012942 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 585395012943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395012944 Walker A motif; other site 585395012945 ATP binding site [chemical binding]; other site 585395012946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 585395012947 Walker B motif; other site 585395012948 arginine finger; other site 585395012949 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 585395012950 DnaA box-binding interface [nucleotide binding]; other site 585395012951 DNA polymerase III subunit beta; Validated; Region: PRK05643 585395012952 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 585395012953 putative DNA binding surface [nucleotide binding]; other site 585395012954 dimer interface [polypeptide binding]; other site 585395012955 beta-clamp/clamp loader binding surface; other site 585395012956 beta-clamp/translesion DNA polymerase binding surface; other site 585395012957 recF protein; Region: recf; TIGR00611 585395012958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395012959 Walker A/P-loop; other site 585395012960 ATP binding site [chemical binding]; other site 585395012961 Q-loop/lid; other site 585395012962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395012963 ABC transporter signature motif; other site 585395012964 Walker B; other site 585395012965 D-loop; other site 585395012966 H-loop/switch region; other site 585395012967 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 585395012968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395012969 Mg2+ binding site [ion binding]; other site 585395012970 G-X-G motif; other site 585395012971 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 585395012972 anchoring element; other site 585395012973 dimer interface [polypeptide binding]; other site 585395012974 ATP binding site [chemical binding]; other site 585395012975 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 585395012976 active site 585395012977 putative metal-binding site [ion binding]; other site 585395012978 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 585395012979 hypothetical protein; Provisional; Region: PRK11426 585395012980 sugar phosphate phosphatase; Provisional; Region: PRK10513 585395012981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395012982 active site 585395012983 motif I; other site 585395012984 motif II; other site 585395012985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395012986 hypothetical protein; Provisional; Region: PRK10215 585395012987 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585395012988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395012989 DNA-binding site [nucleotide binding]; DNA binding site 585395012990 FCD domain; Region: FCD; pfam07729 585395012991 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 585395012992 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 585395012993 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 585395012994 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 585395012995 active site 585395012996 intersubunit interface [polypeptide binding]; other site 585395012997 catalytic residue [active] 585395012998 galactonate dehydratase; Provisional; Region: PRK14017 585395012999 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 585395013000 putative active site pocket [active] 585395013001 putative metal binding site [ion binding]; other site 585395013002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395013003 D-galactonate transporter; Region: 2A0114; TIGR00893 585395013004 putative substrate translocation pore; other site 585395013005 putative oxidoreductase; Provisional; Region: PRK11445 585395013006 hypothetical protein; Provisional; Region: PRK07236 585395013007 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 585395013008 hypothetical protein; Provisional; Region: PRK11616 585395013009 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 585395013010 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 585395013011 putative dimer interface [polypeptide binding]; other site 585395013012 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 585395013013 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 585395013014 putative dimer interface [polypeptide binding]; other site 585395013015 putative transporter; Validated; Region: PRK03818 585395013016 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 585395013017 TrkA-C domain; Region: TrkA_C; pfam02080 585395013018 TrkA-C domain; Region: TrkA_C; pfam02080 585395013019 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 585395013020 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585395013021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395013022 DNA-binding site [nucleotide binding]; DNA binding site 585395013023 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 585395013024 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 585395013025 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 585395013026 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585395013027 active site turn [active] 585395013028 phosphorylation site [posttranslational modification] 585395013029 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 585395013030 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 585395013031 NAD(P) binding site [chemical binding]; other site 585395013032 LDH/MDH dimer interface [polypeptide binding]; other site 585395013033 substrate binding site [chemical binding]; other site 585395013034 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585395013035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395013036 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585395013037 putative transporter; Provisional; Region: PRK10484 585395013038 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 585395013039 Na binding site [ion binding]; other site 585395013040 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 585395013041 Sulfatase; Region: Sulfatase; pfam00884 585395013042 Predicted membrane protein [Function unknown]; Region: COG2149 585395013043 Domain of unknown function (DUF202); Region: DUF202; pfam02656 585395013044 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 585395013045 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 585395013046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395013047 putative substrate translocation pore; other site 585395013048 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 585395013049 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585395013050 PYR/PP interface [polypeptide binding]; other site 585395013051 dimer interface [polypeptide binding]; other site 585395013052 TPP binding site [chemical binding]; other site 585395013053 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585395013054 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585395013055 TPP-binding site [chemical binding]; other site 585395013056 dimer interface [polypeptide binding]; other site 585395013057 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 585395013058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395013059 active site 585395013060 phosphorylation site [posttranslational modification] 585395013061 intermolecular recognition site; other site 585395013062 dimerization interface [polypeptide binding]; other site 585395013063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395013064 DNA binding residues [nucleotide binding] 585395013065 dimerization interface [polypeptide binding]; other site 585395013066 sensory histidine kinase UhpB; Provisional; Region: PRK11644 585395013067 MASE1; Region: MASE1; pfam05231 585395013068 Histidine kinase; Region: HisKA_3; pfam07730 585395013069 regulatory protein UhpC; Provisional; Region: PRK11663 585395013070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395013071 putative substrate translocation pore; other site 585395013072 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 585395013073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395013074 putative substrate translocation pore; other site 585395013075 cryptic adenine deaminase; Provisional; Region: PRK10027 585395013076 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 585395013077 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 585395013078 active site 585395013079 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 585395013080 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585395013081 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 585395013082 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 585395013083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395013084 putative substrate translocation pore; other site 585395013085 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 585395013086 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 585395013087 lipoprotein, YaeC family; Region: TIGR00363 585395013088 EamA-like transporter family; Region: EamA; pfam00892 585395013089 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585395013090 EamA-like transporter family; Region: EamA; pfam00892 585395013091 sugar efflux transporter B; Provisional; Region: PRK15011 585395013092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395013093 putative substrate translocation pore; other site 585395013094 putative transporter; Provisional; Region: PRK11462 585395013095 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 585395013096 putative alpha-glucosidase; Provisional; Region: PRK10658 585395013097 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 585395013098 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 585395013099 active site 585395013100 homotrimer interface [polypeptide binding]; other site 585395013101 catalytic site [active] 585395013102 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 585395013103 AsmA family; Region: AsmA; pfam05170 585395013104 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 585395013105 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 585395013106 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 585395013107 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 585395013108 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 585395013109 generic binding surface II; other site 585395013110 ssDNA binding site; other site 585395013111 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395013112 ATP binding site [chemical binding]; other site 585395013113 putative Mg++ binding site [ion binding]; other site 585395013114 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395013115 nucleotide binding region [chemical binding]; other site 585395013116 ATP-binding site [chemical binding]; other site 585395013117 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 585395013118 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585395013119 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 585395013120 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 585395013121 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585395013122 Zn2+ binding site [ion binding]; other site 585395013123 Mg2+ binding site [ion binding]; other site 585395013124 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 585395013125 synthetase active site [active] 585395013126 NTP binding site [chemical binding]; other site 585395013127 metal binding site [ion binding]; metal-binding site 585395013128 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 585395013129 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 585395013130 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 585395013131 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 585395013132 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 585395013133 catalytic site [active] 585395013134 G-X2-G-X-G-K; other site 585395013135 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 585395013136 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 585395013137 nucleotide binding pocket [chemical binding]; other site 585395013138 K-X-D-G motif; other site 585395013139 catalytic site [active] 585395013140 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 585395013141 Predicted membrane protein [Function unknown]; Region: COG2860 585395013142 UPF0126 domain; Region: UPF0126; pfam03458 585395013143 UPF0126 domain; Region: UPF0126; pfam03458 585395013144 DNA-damage-inducible protein DinD, C-terminal part 585395013145 DNA-damage-inducible protein DinD, N-terminal part 585395013146 Prophage ECO103_P14, untypable 585395013147 Prophage ECO103_P14; transposase InsAB' of insertion sequence IS2, C-terminal fragment 585395013148 Prophage ECO103_P14; transposase InsAB' of insertion sequence IS2, N-terminal fragment 585395013149 IS2 repressor TnpA; Reviewed; Region: PRK09413 585395013150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395013151 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585395013152 Predicted transporter component [General function prediction only]; Region: COG2391 585395013153 Sulphur transport; Region: Sulf_transp; pfam04143 585395013154 PerC transcriptional activator; Region: PerC; pfam06069 585395013155 PerC transcriptional activator; Region: PerC; pfam06069 585395013156 ProQ/FINO family; Region: ProQ; pfam04352 585395013157 putative RNA binding sites [nucleotide binding]; other site 585395013158 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 585395013159 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585395013160 ssDNA binding site [nucleotide binding]; other site 585395013161 dimer interface [polypeptide binding]; other site 585395013162 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585395013163 D5 N terminal like; Region: D5_N; smart00885 585395013164 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 585395013165 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 585395013166 AntA/AntB antirepressor; Region: AntA; pfam08346 585395013167 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 585395013168 integrase; Provisional; Region: PRK09692 585395013169 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585395013170 active site 585395013171 Int/Topo IB signature motif; other site 585395013172 hypothetical protein; Provisional; Region: PRK11820 585395013173 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 585395013174 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 585395013175 ribonuclease PH; Reviewed; Region: rph; PRK00173 585395013176 Ribonuclease PH; Region: RNase_PH_bact; cd11362 585395013177 hexamer interface [polypeptide binding]; other site 585395013178 active site 585395013179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585395013180 active site 585395013181 division inhibitor protein; Provisional; Region: slmA; PRK09480 585395013182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585395013183 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 585395013184 trimer interface [polypeptide binding]; other site 585395013185 active site 585395013186 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 585395013187 Flavoprotein; Region: Flavoprotein; pfam02441 585395013188 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 585395013189 hypothetical protein; Reviewed; Region: PRK00024 585395013190 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585395013191 MPN+ (JAMM) motif; other site 585395013192 Zinc-binding site [ion binding]; other site 585395013193 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 585395013194 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 585395013195 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 585395013196 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 585395013197 DNA binding site [nucleotide binding] 585395013198 catalytic residue [active] 585395013199 H2TH interface [polypeptide binding]; other site 585395013200 putative catalytic residues [active] 585395013201 turnover-facilitating residue; other site 585395013202 intercalation triad [nucleotide binding]; other site 585395013203 8OG recognition residue [nucleotide binding]; other site 585395013204 putative reading head residues; other site 585395013205 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 585395013206 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585395013207 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 585395013208 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 585395013209 active site 585395013210 (T/H)XGH motif; other site 585395013211 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 585395013212 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 585395013213 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585395013214 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 585395013215 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585395013216 putative active site [active] 585395013217 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585395013218 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585395013219 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 585395013220 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 585395013221 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 585395013222 Ligand binding site; other site 585395013223 metal-binding site 585395013224 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 585395013225 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 585395013226 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 585395013227 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 585395013228 Ligand binding site; other site 585395013229 metal-binding site 585395013230 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 585395013231 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 585395013232 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585395013233 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 585395013234 O-antigen ligase RfaL; Provisional; Region: PRK15487 585395013235 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585395013236 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585395013237 putative active site [active] 585395013238 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585395013239 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585395013240 putative active site [active] 585395013241 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 585395013242 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 585395013243 NADP binding site [chemical binding]; other site 585395013244 homopentamer interface [polypeptide binding]; other site 585395013245 substrate binding site [chemical binding]; other site 585395013246 active site 585395013247 hypothetical protein; Provisional; Region: PRK11346 585395013248 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585395013249 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 585395013250 substrate-cofactor binding pocket; other site 585395013251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395013252 catalytic residue [active] 585395013253 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 585395013254 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585395013255 NAD(P) binding site [chemical binding]; other site 585395013256 putative glycosyl transferase; Provisional; Region: PRK10073 585395013257 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 585395013258 active site 585395013259 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 585395013260 NodB motif; other site 585395013261 putative active site [active] 585395013262 putative catalytic site [active] 585395013263 Zn binding site [ion binding]; other site 585395013264 AmiB activator; Provisional; Region: PRK11637 585395013265 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 585395013266 Peptidase family M23; Region: Peptidase_M23; pfam01551 585395013267 phosphoglyceromutase; Provisional; Region: PRK05434 585395013268 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 585395013269 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585395013270 active site residue [active] 585395013271 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 585395013272 GSH binding site [chemical binding]; other site 585395013273 catalytic residues [active] 585395013274 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 585395013275 SecA binding site; other site 585395013276 Preprotein binding site; other site 585395013277 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 585395013278 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 585395013279 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 585395013280 serine acetyltransferase; Provisional; Region: cysE; PRK11132 585395013281 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 585395013282 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585395013283 trimer interface [polypeptide binding]; other site 585395013284 active site 585395013285 substrate binding site [chemical binding]; other site 585395013286 CoA binding site [chemical binding]; other site 585395013287 putative rRNA methylase; Provisional; Region: PRK10358 585395013288 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 585395013289 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585395013290 phosphate binding site [ion binding]; other site 585395013291 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 585395013292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395013293 DNA-binding site [nucleotide binding]; DNA binding site 585395013294 FCD domain; Region: FCD; pfam07729 585395013295 L-lactate permease; Provisional; Region: PRK10420 585395013296 glycolate transporter; Provisional; Region: PRK09695 585395013297 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585395013298 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 585395013299 trimer interface [polypeptide binding]; other site 585395013300 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 585395013301 trimer interface [polypeptide binding]; other site 585395013302 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 585395013303 Haemagglutinin; Region: HIM; pfam05662 585395013304 Haemagglutinin; Region: HIM; pfam05662 585395013305 YadA-like C-terminal region; Region: YadA; pfam03895 585395013306 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 585395013307 hypothetical protein; Provisional; Region: PRK11020 585395013308 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 585395013309 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 585395013310 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 585395013311 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585395013312 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585395013313 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 585395013314 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 585395013315 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 585395013316 active site 585395013317 P-loop; other site 585395013318 phosphorylation site [posttranslational modification] 585395013319 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585395013320 active site 585395013321 phosphorylation site [posttranslational modification] 585395013322 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 585395013323 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585395013324 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395013325 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395013326 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585395013327 Rhs core protein with extension, C-terminal fragment 585395013328 putative lyase; Provisional; Region: PRK09687 585395013329 PAAR motif; Region: PAAR_motif; cl15808 585395013330 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585395013331 RHS Repeat; Region: RHS_repeat; pfam05593 585395013332 RHS Repeat; Region: RHS_repeat; pfam05593 585395013333 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585395013334 RHS Repeat; Region: RHS_repeat; pfam05593 585395013335 RHS Repeat; Region: RHS_repeat; pfam05593 585395013336 RHS protein; Region: RHS; pfam03527 585395013337 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585395013338 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 585395013339 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 585395013340 primosome assembly protein PriA; Validated; Region: PRK05580 585395013341 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395013342 ATP binding site [chemical binding]; other site 585395013343 putative Mg++ binding site [ion binding]; other site 585395013344 helicase superfamily c-terminal domain; Region: HELICc; smart00490 585395013345 ATP-binding site [chemical binding]; other site 585395013346 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585395013347 DNA binding site [nucleotide binding] 585395013348 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 585395013349 domain linker motif; other site 585395013350 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 585395013351 dimerization interface [polypeptide binding]; other site 585395013352 ligand binding site [chemical binding]; other site 585395013353 essential cell division protein FtsN; Provisional; Region: PRK10927 585395013354 cell division protein FtsN; Provisional; Region: PRK12757 585395013355 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 585395013356 active site 585395013357 HslU subunit interaction site [polypeptide binding]; other site 585395013358 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 585395013359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395013360 Walker A motif; other site 585395013361 ATP binding site [chemical binding]; other site 585395013362 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 585395013363 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585395013364 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 585395013365 UbiA prenyltransferase family; Region: UbiA; pfam01040 585395013366 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 585395013367 septal ring assembly protein ZapB; Provisional; Region: PRK15422 585395013368 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 585395013369 amphipathic channel; other site 585395013370 Asn-Pro-Ala signature motifs; other site 585395013371 glycerol kinase; Provisional; Region: glpK; PRK00047 585395013372 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 585395013373 N- and C-terminal domain interface [polypeptide binding]; other site 585395013374 active site 585395013375 MgATP binding site [chemical binding]; other site 585395013376 catalytic site [active] 585395013377 metal binding site [ion binding]; metal-binding site 585395013378 glycerol binding site [chemical binding]; other site 585395013379 homotetramer interface [polypeptide binding]; other site 585395013380 homodimer interface [polypeptide binding]; other site 585395013381 FBP binding site [chemical binding]; other site 585395013382 protein IIAGlc interface [polypeptide binding]; other site 585395013383 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 585395013384 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 585395013385 putative active site [active] 585395013386 ferredoxin-NADP reductase; Provisional; Region: PRK10926 585395013387 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 585395013388 FAD binding pocket [chemical binding]; other site 585395013389 FAD binding motif [chemical binding]; other site 585395013390 phosphate binding motif [ion binding]; other site 585395013391 beta-alpha-beta structure motif; other site 585395013392 NAD binding pocket [chemical binding]; other site 585395013393 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585395013394 Ligand Binding Site [chemical binding]; other site 585395013395 hypothetical protein; Provisional; Region: PRK09981 585395013396 Predicted membrane protein [Function unknown]; Region: COG3152 585395013397 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 585395013398 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 585395013399 triosephosphate isomerase; Provisional; Region: PRK14567 585395013400 substrate binding site [chemical binding]; other site 585395013401 dimer interface [polypeptide binding]; other site 585395013402 catalytic triad [active] 585395013403 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 585395013404 sulfate transporter subunit; Provisional; Region: PRK10752 585395013405 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 585395013406 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 585395013407 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 585395013408 active site 585395013409 ADP/pyrophosphate binding site [chemical binding]; other site 585395013410 dimerization interface [polypeptide binding]; other site 585395013411 allosteric effector site; other site 585395013412 fructose-1,6-bisphosphate binding site; other site 585395013413 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 585395013414 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 585395013415 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 585395013416 dimer interface [polypeptide binding]; other site 585395013417 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 585395013418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395013419 active site 585395013420 intermolecular recognition site; other site 585395013421 dimerization interface [polypeptide binding]; other site 585395013422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395013423 DNA binding site [nucleotide binding] 585395013424 two-component sensor protein; Provisional; Region: cpxA; PRK09470 585395013425 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585395013426 dimerization interface [polypeptide binding]; other site 585395013427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395013428 dimer interface [polypeptide binding]; other site 585395013429 phosphorylation site [posttranslational modification] 585395013430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395013431 ATP binding site [chemical binding]; other site 585395013432 Mg2+ binding site [ion binding]; other site 585395013433 G-X-G motif; other site 585395013434 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 585395013435 MOSC domain; Region: MOSC; pfam03473 585395013436 3-alpha domain; Region: 3-alpha; pfam03475 585395013437 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 585395013438 superoxide dismutase; Provisional; Region: PRK10925 585395013439 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 585395013440 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 585395013441 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 585395013442 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 585395013443 transcriptional activator RhaR; Provisional; Region: PRK13500 585395013444 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585395013445 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395013446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395013447 transcriptional activator RhaS; Provisional; Region: PRK13503 585395013448 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585395013449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395013450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395013451 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 585395013452 N- and C-terminal domain interface [polypeptide binding]; other site 585395013453 active site 585395013454 putative catalytic site [active] 585395013455 metal binding site [ion binding]; metal-binding site 585395013456 ATP binding site [chemical binding]; other site 585395013457 rhamnulokinase; Provisional; Region: rhaB; PRK10640 585395013458 carbohydrate binding site [chemical binding]; other site 585395013459 L-rhamnose isomerase; Provisional; Region: PRK01076 585395013460 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 585395013461 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585395013462 intersubunit interface [polypeptide binding]; other site 585395013463 active site 585395013464 Zn2+ binding site [ion binding]; other site 585395013465 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 585395013466 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585395013467 active site 585395013468 phosphorylation site [posttranslational modification] 585395013469 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 585395013470 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585395013471 active site 585395013472 P-loop; other site 585395013473 phosphorylation site [posttranslational modification] 585395013474 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 585395013475 putative peptidase; Provisional; Region: PRK09864 585395013476 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 585395013477 oligomer interface [polypeptide binding]; other site 585395013478 active site 585395013479 metal binding site [ion binding]; metal-binding site 585395013480 putative frv operon regulatory protein; Provisional; Region: PRK09863 585395013481 HTH domain; Region: HTH_11; pfam08279 585395013482 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585395013483 active site 585395013484 phosphorylation site [posttranslational modification] 585395013485 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 585395013486 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 585395013487 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 585395013488 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585395013489 [4Fe-4S] binding site [ion binding]; other site 585395013490 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585395013491 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585395013492 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 585395013493 molybdopterin cofactor binding site; other site 585395013494 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 585395013495 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 585395013496 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 585395013497 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 585395013498 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 585395013499 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 585395013500 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585395013501 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585395013502 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585395013503 hypothetical protein; Provisional; Region: PRK10030 585395013504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585395013505 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585395013506 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585395013507 predicted protein Orf2 in insertion sequence IS1nuxi4, N-terminal fragment 585395013508 PAAR motif; Region: PAAR_motif; cl15808 585395013509 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585395013510 RHS Repeat; Region: RHS_repeat; pfam05593 585395013511 RHS Repeat; Region: RHS_repeat; pfam05593 585395013512 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585395013513 RHS Repeat; Region: RHS_repeat; pfam05593 585395013514 RHS Repeat; Region: RHS_repeat; pfam05593 585395013515 RHS protein; Region: RHS; pfam03527 585395013516 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585395013517 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 585395013518 putative glutathione S-transferase; Provisional; Region: PRK10357 585395013519 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 585395013520 putative C-terminal domain interface [polypeptide binding]; other site 585395013521 putative GSH binding site (G-site) [chemical binding]; other site 585395013522 putative dimer interface [polypeptide binding]; other site 585395013523 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 585395013524 dimer interface [polypeptide binding]; other site 585395013525 N-terminal domain interface [polypeptide binding]; other site 585395013526 putative substrate binding pocket (H-site) [chemical binding]; other site 585395013527 selenocysteine synthase; Provisional; Region: PRK04311 585395013528 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 585395013529 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 585395013530 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585395013531 catalytic residue [active] 585395013532 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 585395013533 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 585395013534 G1 box; other site 585395013535 putative GEF interaction site [polypeptide binding]; other site 585395013536 GTP/Mg2+ binding site [chemical binding]; other site 585395013537 Switch I region; other site 585395013538 G2 box; other site 585395013539 G3 box; other site 585395013540 Switch II region; other site 585395013541 G4 box; other site 585395013542 G5 box; other site 585395013543 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 585395013544 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 585395013545 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 585395013546 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 585395013547 putative alcohol dehydrogenase; Provisional; Region: PRK09860 585395013548 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 585395013549 dimer interface [polypeptide binding]; other site 585395013550 active site 585395013551 metal binding site [ion binding]; metal-binding site 585395013552 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 585395013553 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 585395013554 NAD(P) binding site [chemical binding]; other site 585395013555 catalytic residues [active] 585395013556 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 585395013557 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585395013558 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395013559 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395013560 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585395013561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395013562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585395013563 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 585395013564 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585395013565 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585395013566 intersubunit interface [polypeptide binding]; other site 585395013567 active site 585395013568 Zn2+ binding site [ion binding]; other site 585395013569 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 585395013570 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585395013571 AP (apurinic/apyrimidinic) site pocket; other site 585395013572 DNA interaction; other site 585395013573 Metal-binding active site; metal-binding site 585395013574 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 585395013575 active site 585395013576 dimer interface [polypeptide binding]; other site 585395013577 magnesium binding site [ion binding]; other site 585395013578 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 585395013579 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 585395013580 putative N- and C-terminal domain interface [polypeptide binding]; other site 585395013581 putative active site [active] 585395013582 MgATP binding site [chemical binding]; other site 585395013583 catalytic site [active] 585395013584 metal binding site [ion binding]; metal-binding site 585395013585 putative xylulose binding site [chemical binding]; other site 585395013586 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585395013587 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 585395013588 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 585395013589 DctM-like transporters; Region: DctM; pfam06808 585395013590 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 585395013591 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 585395013592 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 585395013593 Transcriptional regulator [Transcription]; Region: IclR; COG1414 585395013594 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585395013595 Bacterial transcriptional regulator; Region: IclR; pfam01614 585395013596 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585395013597 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 585395013598 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 585395013599 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585395013600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395013601 homodimer interface [polypeptide binding]; other site 585395013602 catalytic residue [active] 585395013603 alpha-amylase; Reviewed; Region: malS; PRK09505 585395013604 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 585395013605 active site 585395013606 catalytic site [active] 585395013607 hypothetical protein; Provisional; Region: PRK10356 585395013608 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 585395013609 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 585395013610 putative dimerization interface [polypeptide binding]; other site 585395013611 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585395013612 putative ligand binding site [chemical binding]; other site 585395013613 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395013614 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585395013615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395013616 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585395013617 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585395013618 TM-ABC transporter signature motif; other site 585395013619 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 585395013620 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585395013621 Walker A/P-loop; other site 585395013622 ATP binding site [chemical binding]; other site 585395013623 Q-loop/lid; other site 585395013624 ABC transporter signature motif; other site 585395013625 Walker B; other site 585395013626 D-loop; other site 585395013627 H-loop/switch region; other site 585395013628 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585395013629 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 585395013630 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 585395013631 putative ligand binding site [chemical binding]; other site 585395013632 xylose isomerase; Provisional; Region: PRK05474 585395013633 xylose isomerase; Region: xylose_isom_A; TIGR02630 585395013634 xylulokinase; Provisional; Region: PRK15027 585395013635 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 585395013636 N- and C-terminal domain interface [polypeptide binding]; other site 585395013637 active site 585395013638 MgATP binding site [chemical binding]; other site 585395013639 catalytic site [active] 585395013640 metal binding site [ion binding]; metal-binding site 585395013641 xylulose binding site [chemical binding]; other site 585395013642 homodimer interface [polypeptide binding]; other site 585395013643 hypothetical protein; Provisional; Region: PRK11403 585395013644 yiaA/B two helix domain; Region: YiaAB; pfam05360 585395013645 hypothetical protein; Provisional; Region: PRK11383 585395013646 yiaA/B two helix domain; Region: YiaAB; pfam05360 585395013647 yiaA/B two helix domain; Region: YiaAB; pfam05360 585395013648 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 585395013649 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585395013650 YsaB-like lipoprotein; Region: YsaB; pfam13983 585395013651 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 585395013652 dimer interface [polypeptide binding]; other site 585395013653 motif 1; other site 585395013654 active site 585395013655 motif 2; other site 585395013656 motif 3; other site 585395013657 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 585395013658 DALR anticodon binding domain; Region: DALR_1; pfam05746 585395013659 anticodon binding site; other site 585395013660 tRNA binding surface [nucleotide binding]; other site 585395013661 small toxic polypeptide; Provisional; Region: PRK09759 585395013662 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585395013663 DNA-binding site [nucleotide binding]; DNA binding site 585395013664 RNA-binding motif; other site 585395013665 Predicted transcriptional regulator [Transcription]; Region: COG2944 585395013666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395013667 non-specific DNA binding site [nucleotide binding]; other site 585395013668 salt bridge; other site 585395013669 sequence-specific DNA binding site [nucleotide binding]; other site 585395013670 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 585395013671 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 585395013672 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 585395013673 dimerization interface [polypeptide binding]; other site 585395013674 ligand binding site [chemical binding]; other site 585395013675 NADP binding site [chemical binding]; other site 585395013676 catalytic site [active] 585395013677 putative outer membrane lipoprotein; Provisional; Region: PRK10510 585395013678 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585395013679 ligand binding site [chemical binding]; other site 585395013680 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585395013681 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 585395013682 molybdopterin cofactor binding site [chemical binding]; other site 585395013683 substrate binding site [chemical binding]; other site 585395013684 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585395013685 molybdopterin cofactor binding site; other site 585395013686 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585395013687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395013688 Coenzyme A binding pocket [chemical binding]; other site 585395013689 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 585395013690 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 585395013691 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 585395013692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395013693 putative substrate translocation pore; other site 585395013694 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 585395013695 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 585395013696 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585395013697 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585395013698 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 585395013699 PapC N-terminal domain; Region: PapC_N; pfam13954 585395013700 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585395013701 PapC C-terminal domain; Region: PapC_C; pfam13953 585395013702 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 585395013703 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 585395013704 phosphoethanolamine transferase; Provisional; Region: PRK11560 585395013705 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585395013706 Sulfatase; Region: Sulfatase; pfam00884 585395013707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585395013708 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585395013709 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585395013710 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 585395013711 dimerization interface [polypeptide binding]; other site 585395013712 DNA binding site [nucleotide binding] 585395013713 corepressor binding sites; other site 585395013714 cystathionine gamma-synthase; Provisional; Region: PRK08045 585395013715 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 585395013716 homodimer interface [polypeptide binding]; other site 585395013717 substrate-cofactor binding pocket; other site 585395013718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395013719 catalytic residue [active] 585395013720 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 585395013721 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 585395013722 putative catalytic residues [active] 585395013723 putative nucleotide binding site [chemical binding]; other site 585395013724 putative aspartate binding site [chemical binding]; other site 585395013725 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 585395013726 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 585395013727 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 585395013728 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 585395013729 FAD binding site [chemical binding]; other site 585395013730 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 585395013731 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 585395013732 heme binding site [chemical binding]; other site 585395013733 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 585395013734 EamA-like transporter family; Region: EamA; pfam00892 585395013735 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585395013736 EamA-like transporter family; Region: EamA; pfam00892 585395013737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 585395013738 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 585395013739 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 585395013740 dimer interface [polypeptide binding]; other site 585395013741 active site 585395013742 metal binding site [ion binding]; metal-binding site 585395013743 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 585395013744 active site 585395013745 intersubunit interactions; other site 585395013746 catalytic residue [active] 585395013747 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585395013748 dimerization domain swap beta strand [polypeptide binding]; other site 585395013749 regulatory protein interface [polypeptide binding]; other site 585395013750 active site 585395013751 regulatory phosphorylation site [posttranslational modification]; other site 585395013752 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585395013753 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 585395013754 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585395013755 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585395013756 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585395013757 active site 585395013758 phosphorylation site [posttranslational modification] 585395013759 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 585395013760 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 585395013761 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585395013762 active site 585395013763 P-loop; other site 585395013764 phosphorylation site [posttranslational modification] 585395013765 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 585395013766 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 585395013767 dimer interface [polypeptide binding]; other site 585395013768 active site 585395013769 glycine loop; other site 585395013770 pyruvate formate lyase II activase; Provisional; Region: PRK10076 585395013771 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585395013772 active site 585395013773 P-loop; other site 585395013774 phosphorylation site [posttranslational modification] 585395013775 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585395013776 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395013777 hypothetical protein; Provisional; Region: PRK10649 585395013778 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585395013779 Sulfatase; Region: Sulfatase; pfam00884 585395013780 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 585395013781 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 585395013782 acetylornithine deacetylase; Provisional; Region: PRK05111 585395013783 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 585395013784 metal binding site [ion binding]; metal-binding site 585395013785 putative dimer interface [polypeptide binding]; other site 585395013786 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 585395013787 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585395013788 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 585395013789 nucleotide binding site [chemical binding]; other site 585395013790 N-acetyl-L-glutamate binding site [chemical binding]; other site 585395013791 argininosuccinate lyase; Provisional; Region: PRK04833 585395013792 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 585395013793 active sites [active] 585395013794 tetramer interface [polypeptide binding]; other site 585395013795 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 585395013796 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 585395013797 putative active site pocket [active] 585395013798 putative metal binding site [ion binding]; other site 585395013799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395013800 D-galactonate transporter; Region: 2A0114; TIGR00893 585395013801 putative substrate translocation pore; other site 585395013802 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 585395013803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395013804 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 585395013805 dimerization interface [polypeptide binding]; other site 585395013806 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 585395013807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585395013808 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585395013809 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 585395013810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585395013811 hypothetical protein; Provisional; Region: PRK11056 585395013812 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 585395013813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395013814 S-adenosylmethionine binding site [chemical binding]; other site 585395013815 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 585395013816 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585395013817 N-terminal plug; other site 585395013818 ligand-binding site [chemical binding]; other site 585395013819 glutamate racemase; Provisional; Region: PRK00865 585395013820 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 585395013821 FAD binding domain; Region: FAD_binding_4; pfam01565 585395013822 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 585395013823 Biotin operon repressor [Transcription]; Region: BirA; COG1654 585395013824 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 585395013825 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 585395013826 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 585395013827 pantothenate kinase; Provisional; Region: PRK05439 585395013828 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 585395013829 ATP-binding site [chemical binding]; other site 585395013830 CoA-binding site [chemical binding]; other site 585395013831 Mg2+-binding site [ion binding]; other site 585395013832 elongation factor Tu; Reviewed; Region: PRK00049 585395013833 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 585395013834 G1 box; other site 585395013835 GEF interaction site [polypeptide binding]; other site 585395013836 GTP/Mg2+ binding site [chemical binding]; other site 585395013837 Switch I region; other site 585395013838 G2 box; other site 585395013839 G3 box; other site 585395013840 Switch II region; other site 585395013841 G4 box; other site 585395013842 G5 box; other site 585395013843 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 585395013844 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 585395013845 Antibiotic Binding Site [chemical binding]; other site 585395013846 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 585395013847 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 585395013848 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 585395013849 putative homodimer interface [polypeptide binding]; other site 585395013850 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 585395013851 heterodimer interface [polypeptide binding]; other site 585395013852 homodimer interface [polypeptide binding]; other site 585395013853 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 585395013854 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 585395013855 23S rRNA interface [nucleotide binding]; other site 585395013856 L7/L12 interface [polypeptide binding]; other site 585395013857 putative thiostrepton binding site; other site 585395013858 L25 interface [polypeptide binding]; other site 585395013859 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 585395013860 mRNA/rRNA interface [nucleotide binding]; other site 585395013861 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 585395013862 23S rRNA interface [nucleotide binding]; other site 585395013863 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 585395013864 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 585395013865 core dimer interface [polypeptide binding]; other site 585395013866 peripheral dimer interface [polypeptide binding]; other site 585395013867 L10 interface [polypeptide binding]; other site 585395013868 L11 interface [polypeptide binding]; other site 585395013869 putative EF-Tu interaction site [polypeptide binding]; other site 585395013870 putative EF-G interaction site [polypeptide binding]; other site 585395013871 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 585395013872 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 585395013873 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 585395013874 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 585395013875 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 585395013876 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 585395013877 RPB3 interaction site [polypeptide binding]; other site 585395013878 RPB1 interaction site [polypeptide binding]; other site 585395013879 RPB11 interaction site [polypeptide binding]; other site 585395013880 RPB10 interaction site [polypeptide binding]; other site 585395013881 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 585395013882 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 585395013883 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 585395013884 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 585395013885 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 585395013886 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 585395013887 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 585395013888 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 585395013889 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 585395013890 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 585395013891 DNA binding site [nucleotide binding] 585395013892 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 585395013893 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 585395013894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395013895 FeS/SAM binding site; other site 585395013896 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 585395013897 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 585395013898 ThiS interaction site; other site 585395013899 putative active site [active] 585395013900 tetramer interface [polypeptide binding]; other site 585395013901 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 585395013902 thiS-thiF/thiG interaction site; other site 585395013903 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 585395013904 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 585395013905 ATP binding site [chemical binding]; other site 585395013906 substrate interface [chemical binding]; other site 585395013907 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 585395013908 thiamine phosphate binding site [chemical binding]; other site 585395013909 active site 585395013910 pyrophosphate binding site [ion binding]; other site 585395013911 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 585395013912 ThiC-associated domain; Region: ThiC-associated; pfam13667 585395013913 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 585395013914 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 585395013915 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 585395013916 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 585395013917 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 585395013918 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 585395013919 putative NADH binding site [chemical binding]; other site 585395013920 putative active site [active] 585395013921 nudix motif; other site 585395013922 putative metal binding site [ion binding]; other site 585395013923 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 585395013924 substrate binding site [chemical binding]; other site 585395013925 active site 585395013926 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 585395013927 Active_site [active] 585395013928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 585395013929 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585395013930 IHF dimer interface [polypeptide binding]; other site 585395013931 IHF - DNA interface [nucleotide binding]; other site 585395013932 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 585395013933 zinc resistance protein; Provisional; Region: zraP; PRK11546 585395013934 dimer interface [polypeptide binding]; other site 585395013935 sensor protein ZraS; Provisional; Region: PRK10364 585395013936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395013937 dimer interface [polypeptide binding]; other site 585395013938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395013939 ATP binding site [chemical binding]; other site 585395013940 Mg2+ binding site [ion binding]; other site 585395013941 G-X-G motif; other site 585395013942 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 585395013943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395013944 active site 585395013945 phosphorylation site [posttranslational modification] 585395013946 intermolecular recognition site; other site 585395013947 dimerization interface [polypeptide binding]; other site 585395013948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395013949 Walker A motif; other site 585395013950 ATP binding site [chemical binding]; other site 585395013951 Walker B motif; other site 585395013952 arginine finger; other site 585395013953 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585395013954 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 585395013955 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 585395013956 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 585395013957 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 585395013958 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 585395013959 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 585395013960 purine monophosphate binding site [chemical binding]; other site 585395013961 dimer interface [polypeptide binding]; other site 585395013962 putative catalytic residues [active] 585395013963 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 585395013964 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585395013965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395013966 Coenzyme A binding pocket [chemical binding]; other site 585395013967 homoserine O-succinyltransferase; Provisional; Region: PRK05368 585395013968 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 585395013969 proposed active site lysine [active] 585395013970 conserved cys residue [active] 585395013971 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 585395013972 malate synthase A; Region: malate_syn_A; TIGR01344 585395013973 active site 585395013974 isocitrate lyase; Provisional; Region: PRK15063 585395013975 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 585395013976 tetramer interface [polypeptide binding]; other site 585395013977 active site 585395013978 Mg2+/Mn2+ binding site [ion binding]; other site 585395013979 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 585395013980 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 585395013981 T3SS effector-like protein EspL-homolog, C-terminal 585395013982 T3SS effector-like protein EspL-homolog, N-terminal part 585395013983 transcriptional repressor IclR; Provisional; Region: PRK11569 585395013984 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585395013985 Bacterial transcriptional regulator; Region: IclR; pfam01614 585395013986 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 585395013987 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 585395013988 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 585395013989 substrate binding pocket [chemical binding]; other site 585395013990 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 585395013991 B12 binding site [chemical binding]; other site 585395013992 cobalt ligand [ion binding]; other site 585395013993 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 585395013994 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 585395013995 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 585395013996 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 585395013997 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 585395013998 active site pocket [active] 585395013999 oxyanion hole [active] 585395014000 catalytic triad [active] 585395014001 active site nucleophile [active] 585395014002 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 585395014003 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585395014004 RNA binding surface [nucleotide binding]; other site 585395014005 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 585395014006 probable active site [active] 585395014007 hypothetical protein; Provisional; Region: PRK10515 585395014008 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 585395014009 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 585395014010 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 585395014011 Zeta toxin; Region: Zeta_toxin; pfam06414 585395014012 aspartate kinase III; Validated; Region: PRK09084 585395014013 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 585395014014 nucleotide binding site [chemical binding]; other site 585395014015 putative catalytic residues [active] 585395014016 aspartate binding site [chemical binding]; other site 585395014017 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 585395014018 lysine allosteric regulatory site; other site 585395014019 dimer interface [polypeptide binding]; other site 585395014020 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 585395014021 dimer interface [polypeptide binding]; other site 585395014022 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 585395014023 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 585395014024 active site 585395014025 dimer interface [polypeptide binding]; other site 585395014026 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 585395014027 dimer interface [polypeptide binding]; other site 585395014028 active site 585395014029 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 585395014030 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 585395014031 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 585395014032 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 585395014033 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 585395014034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395014035 putative substrate translocation pore; other site 585395014036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395014037 part of maltose permease MalG, inner membrane; membrane component of ABC superfamily 585395014038 part of maltose permease MalF, periplasmic; membrane component of ABC superfamily 585395014039 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 585395014040 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 585395014041 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 585395014042 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 585395014043 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585395014044 Walker A/P-loop; other site 585395014045 ATP binding site [chemical binding]; other site 585395014046 Q-loop/lid; other site 585395014047 ABC transporter signature motif; other site 585395014048 Walker B; other site 585395014049 D-loop; other site 585395014050 H-loop/switch region; other site 585395014051 TOBE domain; Region: TOBE_2; pfam08402 585395014052 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585395014053 trimer interface; other site 585395014054 sugar binding site [chemical binding]; other site 585395014055 maltose regulon periplasmic protein; Provisional; Region: PRK10564 585395014056 T3SS effector-like protein EspX-homolog, N-terminal 585395014057 T3SS effector-like protein EspX-homolog, C-terminal 585395014058 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 585395014059 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 585395014060 UbiA prenyltransferase family; Region: UbiA; pfam01040 585395014061 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 585395014062 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 585395014063 putative acyl-acceptor binding pocket; other site 585395014064 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 585395014065 LexA repressor; Validated; Region: PRK00215 585395014066 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 585395014067 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585395014068 Catalytic site [active] 585395014069 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 585395014070 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 585395014071 hypothetical protein; Provisional; Region: PRK10428 585395014072 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 585395014073 metal binding site 2 [ion binding]; metal-binding site 585395014074 putative DNA binding helix; other site 585395014075 metal binding site 1 [ion binding]; metal-binding site 585395014076 dimer interface [polypeptide binding]; other site 585395014077 structural Zn2+ binding site [ion binding]; other site 585395014078 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 585395014079 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 585395014080 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585395014081 FMN binding site [chemical binding]; other site 585395014082 active site 585395014083 catalytic residues [active] 585395014084 substrate binding site [chemical binding]; other site 585395014085 phage shock protein G; Reviewed; Region: pspG; PRK09459 585395014086 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 585395014087 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 585395014088 NADP binding site [chemical binding]; other site 585395014089 dimer interface [polypeptide binding]; other site 585395014090 replicative DNA helicase; Provisional; Region: PRK08006 585395014091 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 585395014092 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 585395014093 Walker A motif; other site 585395014094 ATP binding site [chemical binding]; other site 585395014095 Walker B motif; other site 585395014096 DNA binding loops [nucleotide binding] 585395014097 alanine racemase; Reviewed; Region: alr; PRK00053 585395014098 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 585395014099 active site 585395014100 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585395014101 substrate binding site [chemical binding]; other site 585395014102 catalytic residues [active] 585395014103 dimer interface [polypeptide binding]; other site 585395014104 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 585395014105 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585395014106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395014107 homodimer interface [polypeptide binding]; other site 585395014108 catalytic residue [active] 585395014109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395014110 active site 585395014111 motif I; other site 585395014112 motif II; other site 585395014113 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 585395014114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 585395014115 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 585395014116 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 585395014117 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 585395014118 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 585395014119 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 585395014120 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585395014121 dimer interface [polypeptide binding]; other site 585395014122 ssDNA binding site [nucleotide binding]; other site 585395014123 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585395014124 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 585395014125 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 585395014126 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585395014127 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585395014128 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 585395014129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395014130 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 585395014131 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 585395014132 DNA binding residues [nucleotide binding] 585395014133 dimer interface [polypeptide binding]; other site 585395014134 [2Fe-2S] cluster binding site [ion binding]; other site 585395014135 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585395014136 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 585395014137 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 585395014138 T3SS effector-like protein EspX-homolog, C-terminal 585395014139 T3SS effector-like protein EspX-homolog, N-terminal 585395014140 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 585395014141 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 585395014142 Na binding site [ion binding]; other site 585395014143 Predicted membrane protein [Function unknown]; Region: COG3162 585395014144 acetyl-CoA synthetase; Provisional; Region: PRK00174 585395014145 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 585395014146 active site 585395014147 CoA binding site [chemical binding]; other site 585395014148 acyl-activating enzyme (AAE) consensus motif; other site 585395014149 AMP binding site [chemical binding]; other site 585395014150 acetate binding site [chemical binding]; other site 585395014151 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 585395014152 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 585395014153 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 585395014154 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 585395014155 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 585395014156 heme lyase subunit NrfE; Provisional; Region: PRK10369 585395014157 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 585395014158 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 585395014159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585395014160 binding surface 585395014161 TPR motif; other site 585395014162 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 585395014163 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585395014164 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585395014165 Sel1-like repeats; Region: SEL1; smart00671 585395014166 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 585395014167 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 585395014168 [4Fe-4S] binding site [ion binding]; other site 585395014169 molybdopterin cofactor binding site; other site 585395014170 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 585395014171 molybdopterin cofactor binding site; other site 585395014172 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 585395014173 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 585395014174 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585395014175 multidrug resistance protein MdtN; Provisional; Region: PRK10476 585395014176 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585395014177 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395014178 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 585395014179 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 585395014180 D-allose kinase; Provisional; Region: PRK09698 585395014181 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585395014182 nucleotide binding site [chemical binding]; other site 585395014183 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 585395014184 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 585395014185 substrate binding site [chemical binding]; other site 585395014186 hexamer interface [polypeptide binding]; other site 585395014187 metal binding site [ion binding]; metal-binding site 585395014188 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585395014189 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585395014190 TM-ABC transporter signature motif; other site 585395014191 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585395014192 ABC transporter; Region: ABC_tran; pfam00005 585395014193 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 585395014194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395014195 Walker A/P-loop; other site 585395014196 ATP binding site [chemical binding]; other site 585395014197 Q-loop/lid; other site 585395014198 ABC transporter signature motif; other site 585395014199 Walker B; other site 585395014200 D-loop; other site 585395014201 H-loop/switch region; other site 585395014202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395014203 D-allose transporter subunit; Provisional; Region: PRK09701 585395014204 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 585395014205 ligand binding site [chemical binding]; other site 585395014206 dimerization interface [polypeptide binding]; other site 585395014207 zinc binding site [ion binding]; other site 585395014208 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 585395014209 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585395014210 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585395014211 putative active site [active] 585395014212 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 585395014213 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 585395014214 putative hydrolase; Provisional; Region: PRK02113 585395014215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395014216 Coenzyme A binding pocket [chemical binding]; other site 585395014217 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 585395014218 AAA domain; Region: AAA_18; pfam13238 585395014219 active site 585395014220 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 585395014221 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 585395014222 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 585395014223 active site 585395014224 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 585395014225 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585395014226 Walker A/P-loop; other site 585395014227 ATP binding site [chemical binding]; other site 585395014228 Q-loop/lid; other site 585395014229 ABC transporter signature motif; other site 585395014230 Walker B; other site 585395014231 D-loop; other site 585395014232 H-loop/switch region; other site 585395014233 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 585395014234 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585395014235 Walker A/P-loop; other site 585395014236 ATP binding site [chemical binding]; other site 585395014237 Q-loop/lid; other site 585395014238 ABC transporter signature motif; other site 585395014239 Walker B; other site 585395014240 D-loop; other site 585395014241 H-loop/switch region; other site 585395014242 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585395014243 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 585395014244 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 585395014245 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 585395014246 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 585395014247 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 585395014248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395014249 DNA-binding site [nucleotide binding]; DNA binding site 585395014250 UTRA domain; Region: UTRA; pfam07702 585395014251 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 585395014252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585395014253 dimer interface [polypeptide binding]; other site 585395014254 conserved gate region; other site 585395014255 putative PBP binding loops; other site 585395014256 ABC-ATPase subunit interface; other site 585395014257 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 585395014258 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585395014259 substrate binding pocket [chemical binding]; other site 585395014260 membrane-bound complex binding site; other site 585395014261 hinge residues; other site 585395014262 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 585395014263 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 585395014264 Walker A/P-loop; other site 585395014265 ATP binding site [chemical binding]; other site 585395014266 Q-loop/lid; other site 585395014267 ABC transporter signature motif; other site 585395014268 Walker B; other site 585395014269 D-loop; other site 585395014270 H-loop/switch region; other site 585395014271 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 585395014272 dimer interface [polypeptide binding]; other site 585395014273 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585395014274 hypothetical protein; Provisional; Region: PRK10220 585395014275 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 585395014276 PhnA protein; Region: PhnA; pfam03831 585395014277 hypothetical protein; Provisional; Region: PRK09866 585395014278 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585395014279 G1 box; other site 585395014280 GTP/Mg2+ binding site [chemical binding]; other site 585395014281 G2 box; other site 585395014282 Switch I region; other site 585395014283 G3 box; other site 585395014284 Switch II region; other site 585395014285 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 585395014286 G2 box; other site 585395014287 Switch I region; other site 585395014288 G3 box; other site 585395014289 Switch II region; other site 585395014290 G4 box; other site 585395014291 G5 box; other site 585395014292 YjcZ-like protein; Region: YjcZ; pfam13990 585395014293 proline/glycine betaine transporter; Provisional; Region: PRK10642 585395014294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395014295 putative substrate translocation pore; other site 585395014296 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 585395014297 sensor protein BasS/PmrB; Provisional; Region: PRK10755 585395014298 HAMP domain; Region: HAMP; pfam00672 585395014299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395014300 dimer interface [polypeptide binding]; other site 585395014301 phosphorylation site [posttranslational modification] 585395014302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395014303 ATP binding site [chemical binding]; other site 585395014304 Mg2+ binding site [ion binding]; other site 585395014305 G-X-G motif; other site 585395014306 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 585395014307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395014308 active site 585395014309 phosphorylation site [posttranslational modification] 585395014310 intermolecular recognition site; other site 585395014311 dimerization interface [polypeptide binding]; other site 585395014312 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395014313 DNA binding site [nucleotide binding] 585395014314 putative metal dependent hydrolase; Provisional; Region: PRK11598 585395014315 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585395014316 Sulfatase; Region: Sulfatase; pfam00884 585395014317 arginine:agmatin antiporter; Provisional; Region: PRK10644 585395014318 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585395014319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395014320 arginine decarboxylase; Provisional; Region: PRK15029 585395014321 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585395014322 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585395014323 homodimer interface [polypeptide binding]; other site 585395014324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395014325 catalytic residue [active] 585395014326 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585395014327 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 585395014328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395014329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395014330 alpha-galactosidase; Provisional; Region: PRK15076 585395014331 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 585395014332 NAD binding site [chemical binding]; other site 585395014333 sugar binding site [chemical binding]; other site 585395014334 divalent metal binding site [ion binding]; other site 585395014335 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 585395014336 dimer interface [polypeptide binding]; other site 585395014337 melibiose:sodium symporter; Provisional; Region: PRK10429 585395014338 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 585395014339 hypothetical protein; Provisional; Region: PRK09867 585395014340 fumarate hydratase; Provisional; Region: PRK15389 585395014341 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 585395014342 Fumarase C-terminus; Region: Fumerase_C; pfam05683 585395014343 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 585395014344 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 585395014345 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 585395014346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395014347 active site 585395014348 phosphorylation site [posttranslational modification] 585395014349 intermolecular recognition site; other site 585395014350 dimerization interface [polypeptide binding]; other site 585395014351 Transcriptional regulator; Region: CitT; pfam12431 585395014352 sensory histidine kinase DcuS; Provisional; Region: PRK11086 585395014353 PAS domain; Region: PAS; smart00091 585395014354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395014355 ATP binding site [chemical binding]; other site 585395014356 Mg2+ binding site [ion binding]; other site 585395014357 G-X-G motif; other site 585395014358 Uncharacterized conserved protein [Function unknown]; Region: COG3592 585395014359 Predicted acetyltransferase [General function prediction only]; Region: COG2388 585395014360 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 585395014361 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 585395014362 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 585395014363 dimer interface [polypeptide binding]; other site 585395014364 putative anticodon binding site; other site 585395014365 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 585395014366 motif 1; other site 585395014367 active site 585395014368 motif 2; other site 585395014369 motif 3; other site 585395014370 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 585395014371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395014372 putative substrate translocation pore; other site 585395014373 POT family; Region: PTR2; pfam00854 585395014374 lysine decarboxylase CadA; Provisional; Region: PRK15400 585395014375 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585395014376 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585395014377 homodimer interface [polypeptide binding]; other site 585395014378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395014379 catalytic residue [active] 585395014380 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585395014381 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 585395014382 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 585395014383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395014384 DNA binding site [nucleotide binding] 585395014385 Integrative element ECO103_IE05 585395014386 Methyltransferase domain; Region: Methyltransf_27; pfam13708 585395014387 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 585395014388 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 585395014389 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585395014390 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585395014391 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585395014392 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585395014393 MPN+ (JAMM) motif; other site 585395014394 Zinc-binding site [ion binding]; other site 585395014395 Antirestriction protein; Region: Antirestrict; pfam03230 585395014396 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585395014397 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585395014398 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 585395014399 hypothetical protein; Provisional; Region: PRK09945 585395014400 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585395014401 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585395014402 Autotransporter beta-domain; Region: Autotransporter; smart00869 585395014403 Predicted GTPase [General function prediction only]; Region: COG3596 585395014404 YfjP GTPase; Region: YfjP; cd11383 585395014405 G1 box; other site 585395014406 GTP/Mg2+ binding site [chemical binding]; other site 585395014407 Switch I region; other site 585395014408 G2 box; other site 585395014409 Switch II region; other site 585395014410 G3 box; other site 585395014411 G4 box; other site 585395014412 G5 box; other site 585395014413 Integrative element ECO103_IE05; transposase OrfB protein of insertion sequence IS629, C-terminal fragment 585395014414 Integrative element ECO103_IE05; transposase OrfA protein of insertion sequence IS629, N-terminal fragment 585395014415 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 585395014416 Haemolysin expression modulating protein; Region: HHA; cl11501 585395014417 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585395014418 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585395014419 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585395014420 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585395014421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585395014422 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585395014423 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585395014424 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585395014425 Transposase; Region: HTH_Tnp_1; cl17663 585395014426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395014427 putative transposase OrfB; Reviewed; Region: PHA02517 585395014428 HTH-like domain; Region: HTH_21; pfam13276 585395014429 Integrase core domain; Region: rve; pfam00665 585395014430 Integrase core domain; Region: rve_3; pfam13683 585395014431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585395014432 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585395014433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395014434 Transposase; Region: HTH_Tnp_1; pfam01527 585395014435 Integrative element ECO103_IE05; transposase of insertion sequence IS604, N-terminal fragment 585395014436 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 585395014437 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 585395014438 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 585395014439 cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586 585395014440 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 585395014441 Integrative element ECO103_IE05; predicted transposase of insertion sequence IS630, partial 585395014442 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 585395014443 type III secretion system protein; Provisional; Region: PRK15384; cl14665 585395014444 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 585395014445 Integrative element ECO103_IE05; predicted transposase of insertion sequence IS608, C-terminal fragment 585395014446 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585395014447 Nuclease-related domain; Region: NERD; pfam08378 585395014448 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585395014449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585395014450 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585395014451 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585395014452 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585395014453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585395014454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 585395014455 Homeodomain-like domain; Region: HTH_23; pfam13384 585395014456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395014457 Transposase; Region: HTH_Tnp_1; pfam01527 585395014458 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585395014459 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585395014460 integrase; Provisional; Region: PRK09692 585395014461 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585395014462 active site 585395014463 Int/Topo IB signature motif; other site 585395014464 putative transcriptional regulator; Provisional; Region: PRK11640 585395014465 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585395014466 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 585395014467 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 585395014468 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 585395014469 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 585395014470 DsbD alpha interface [polypeptide binding]; other site 585395014471 catalytic residues [active] 585395014472 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 585395014473 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 585395014474 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 585395014475 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 585395014476 Aspartase; Region: Aspartase; cd01357 585395014477 active sites [active] 585395014478 tetramer interface [polypeptide binding]; other site 585395014479 inner membrane protein, C-terminal part 585395014480 putative transporter; Provisional; Region: PRK11021 585395014481 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 585395014482 oligomerisation interface [polypeptide binding]; other site 585395014483 mobile loop; other site 585395014484 roof hairpin; other site 585395014485 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 585395014486 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 585395014487 ring oligomerisation interface [polypeptide binding]; other site 585395014488 ATP/Mg binding site [chemical binding]; other site 585395014489 stacking interactions; other site 585395014490 hinge regions; other site 585395014491 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 585395014492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585395014493 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585395014494 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585395014495 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 585395014496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395014497 FeS/SAM binding site; other site 585395014498 elongation factor P; Validated; Region: PRK00529 585395014499 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 585395014500 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 585395014501 RNA binding site [nucleotide binding]; other site 585395014502 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 585395014503 RNA binding site [nucleotide binding]; other site 585395014504 entericidin A; Provisional; Region: PRK09810 585395014505 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 585395014506 multidrug efflux system protein; Provisional; Region: PRK11431 585395014507 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 585395014508 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 585395014509 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 585395014510 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585395014511 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 585395014512 Iron-sulfur protein interface; other site 585395014513 proximal quinone binding site [chemical binding]; other site 585395014514 C-subunit interface; other site 585395014515 distal quinone binding site; other site 585395014516 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 585395014517 D-subunit interface [polypeptide binding]; other site 585395014518 Iron-sulfur protein interface; other site 585395014519 proximal quinone binding site [chemical binding]; other site 585395014520 distal quinone binding site [chemical binding]; other site 585395014521 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 585395014522 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 585395014523 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 585395014524 L-aspartate oxidase; Provisional; Region: PRK06175 585395014525 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585395014526 poxB regulator PoxA; Provisional; Region: PRK09350 585395014527 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 585395014528 motif 1; other site 585395014529 dimer interface [polypeptide binding]; other site 585395014530 active site 585395014531 motif 2; other site 585395014532 motif 3; other site 585395014533 inner membrane transporter YjeM; Provisional; Region: PRK15238 585395014534 putative mechanosensitive channel protein; Provisional; Region: PRK10929 585395014535 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 585395014536 DNA-binding site [nucleotide binding]; DNA binding site 585395014537 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 585395014538 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585395014539 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 585395014540 GTPase RsgA; Reviewed; Region: PRK12288 585395014541 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 585395014542 RNA binding site [nucleotide binding]; other site 585395014543 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 585395014544 GTPase/Zn-binding domain interface [polypeptide binding]; other site 585395014545 GTP/Mg2+ binding site [chemical binding]; other site 585395014546 G4 box; other site 585395014547 G5 box; other site 585395014548 G1 box; other site 585395014549 Switch I region; other site 585395014550 G2 box; other site 585395014551 G3 box; other site 585395014552 Switch II region; other site 585395014553 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 585395014554 catalytic site [active] 585395014555 putative active site [active] 585395014556 putative substrate binding site [chemical binding]; other site 585395014557 dimer interface [polypeptide binding]; other site 585395014558 epoxyqueuosine reductase; Region: TIGR00276 585395014559 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 585395014560 putative carbohydrate kinase; Provisional; Region: PRK10565 585395014561 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 585395014562 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 585395014563 putative substrate binding site [chemical binding]; other site 585395014564 putative ATP binding site [chemical binding]; other site 585395014565 ADP-binding protein; Provisional; Region: PRK10646 585395014566 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 585395014567 AMIN domain; Region: AMIN; pfam11741 585395014568 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585395014569 active site 585395014570 metal binding site [ion binding]; metal-binding site 585395014571 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 585395014572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395014573 ATP binding site [chemical binding]; other site 585395014574 Mg2+ binding site [ion binding]; other site 585395014575 G-X-G motif; other site 585395014576 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 585395014577 ATP binding site [chemical binding]; other site 585395014578 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 585395014579 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 585395014580 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 585395014581 bacterial Hfq-like; Region: Hfq; cd01716 585395014582 hexamer interface [polypeptide binding]; other site 585395014583 Sm1 motif; other site 585395014584 RNA binding site [nucleotide binding]; other site 585395014585 Sm2 motif; other site 585395014586 GTPase HflX; Provisional; Region: PRK11058 585395014587 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 585395014588 HflX GTPase family; Region: HflX; cd01878 585395014589 G1 box; other site 585395014590 GTP/Mg2+ binding site [chemical binding]; other site 585395014591 Switch I region; other site 585395014592 G2 box; other site 585395014593 G3 box; other site 585395014594 Switch II region; other site 585395014595 G4 box; other site 585395014596 G5 box; other site 585395014597 FtsH protease regulator HflK; Provisional; Region: PRK10930 585395014598 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 585395014599 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 585395014600 FtsH protease regulator HflC; Provisional; Region: PRK11029 585395014601 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 585395014602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 585395014603 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 585395014604 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 585395014605 GDP-binding site [chemical binding]; other site 585395014606 ACT binding site; other site 585395014607 IMP binding site; other site 585395014608 Predicted transcriptional regulator [Transcription]; Region: COG1959 585395014609 transcriptional repressor NsrR; Provisional; Region: PRK11014 585395014610 exoribonuclease R; Provisional; Region: PRK11642 585395014611 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 585395014612 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 585395014613 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 585395014614 RNB domain; Region: RNB; pfam00773 585395014615 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 585395014616 RNA binding site [nucleotide binding]; other site 585395014617 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 585395014618 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 585395014619 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585395014620 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 585395014621 PspA/IM30 family; Region: PspA_IM30; pfam04012 585395014622 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 585395014623 Predicted membrane protein [Function unknown]; Region: COG3766 585395014624 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 585395014625 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 585395014626 Predicted integral membrane protein [Function unknown]; Region: COG5463 585395014627 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585395014628 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 585395014629 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 585395014630 FAD binding site [chemical binding]; other site 585395014631 substrate binding site [chemical binding]; other site 585395014632 catalytic residues [active] 585395014633 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585395014634 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 585395014635 esterase; Provisional; Region: PRK10566 585395014636 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585395014637 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585395014638 transcriptional repressor UlaR; Provisional; Region: PRK13509 585395014639 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585395014640 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585395014641 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 585395014642 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 585395014643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 585395014644 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 585395014645 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 585395014646 active site 585395014647 P-loop; other site 585395014648 phosphorylation site [posttranslational modification] 585395014649 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585395014650 active site 585395014651 phosphorylation site [posttranslational modification] 585395014652 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 585395014653 active site 585395014654 dimer interface [polypeptide binding]; other site 585395014655 magnesium binding site [ion binding]; other site 585395014656 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 585395014657 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585395014658 AP (apurinic/apyrimidinic) site pocket; other site 585395014659 DNA interaction; other site 585395014660 Metal-binding active site; metal-binding site 585395014661 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585395014662 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585395014663 intersubunit interface [polypeptide binding]; other site 585395014664 active site 585395014665 Zn2+ binding site [ion binding]; other site 585395014666 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585395014667 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 585395014668 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 585395014669 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 585395014670 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 585395014671 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 585395014672 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585395014673 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 585395014674 DctM-like transporters; Region: DctM; pfam06808 585395014675 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 585395014676 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 585395014677 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 585395014678 L-aspartate oxidase; Provisional; Region: PRK06175 585395014679 L-aspartate oxidase; Provisional; Region: PRK06175 585395014680 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 585395014681 Coenzyme A transferase; Region: CoA_trans; smart00882 585395014682 Coenzyme A transferase; Region: CoA_trans; cl17247 585395014683 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 585395014684 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585395014685 substrate binding site [chemical binding]; other site 585395014686 oxyanion hole (OAH) forming residues; other site 585395014687 trimer interface [polypeptide binding]; other site 585395014688 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 585395014689 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 585395014690 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 585395014691 putative NAD(P) binding site [chemical binding]; other site 585395014692 active site 585395014693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585395014694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585395014695 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 585395014696 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 585395014697 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 585395014698 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 585395014699 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585395014700 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 585395014701 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 585395014702 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 585395014703 Hemerythrin-like domain; Region: Hr-like; cd12108 585395014704 Fe binding site [ion binding]; other site 585395014705 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 585395014706 EamA-like transporter family; Region: EamA; pfam00892 585395014707 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 585395014708 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 585395014709 NADP binding site [chemical binding]; other site 585395014710 Predicted transcriptional regulators [Transcription]; Region: COG1733 585395014711 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 585395014712 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 585395014713 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 585395014714 active site 585395014715 metal binding site [ion binding]; metal-binding site 585395014716 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585395014717 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 585395014718 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 585395014719 active site 585395014720 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 585395014721 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 585395014722 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 585395014723 Domain of unknown function DUF21; Region: DUF21; pfam01595 585395014724 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585395014725 Transporter associated domain; Region: CorC_HlyC; smart01091 585395014726 methionine sulfoxide reductase A; Provisional; Region: PRK00058 585395014727 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 585395014728 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585395014729 Surface antigen; Region: Bac_surface_Ag; pfam01103 585395014730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 585395014731 Family of unknown function (DUF490); Region: DUF490; pfam04357 585395014732 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 585395014733 putative active site pocket [active] 585395014734 dimerization interface [polypeptide binding]; other site 585395014735 putative catalytic residue [active] 585395014736 antitoxin ChpS; Provisional; Region: PRK11347 585395014737 toxin ChpB; Provisional; Region: PRK09812 585395014738 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 585395014739 dimer interface [polypeptide binding]; other site 585395014740 substrate binding site [chemical binding]; other site 585395014741 metal binding sites [ion binding]; metal-binding site 585395014742 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 585395014743 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 585395014744 putative ligand binding site [chemical binding]; other site 585395014745 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585395014746 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585395014747 Walker A/P-loop; other site 585395014748 ATP binding site [chemical binding]; other site 585395014749 Q-loop/lid; other site 585395014750 ABC transporter signature motif; other site 585395014751 Walker B; other site 585395014752 D-loop; other site 585395014753 H-loop/switch region; other site 585395014754 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585395014755 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585395014756 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585395014757 TM-ABC transporter signature motif; other site 585395014758 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585395014759 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585395014760 TM-ABC transporter signature motif; other site 585395014761 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 585395014762 AMP binding site [chemical binding]; other site 585395014763 metal binding site [ion binding]; metal-binding site 585395014764 active site 585395014765 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 585395014766 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585395014767 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585395014768 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585395014769 hypothetical protein; Provisional; Region: PRK05255 585395014770 peptidase PmbA; Provisional; Region: PRK11040 585395014771 cytochrome b562; Provisional; Region: PRK15058 585395014772 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 585395014773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395014774 FeS/SAM binding site; other site 585395014775 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 585395014776 ATP cone domain; Region: ATP-cone; pfam03477 585395014777 Class III ribonucleotide reductase; Region: RNR_III; cd01675 585395014778 effector binding site; other site 585395014779 active site 585395014780 Zn binding site [ion binding]; other site 585395014781 glycine loop; other site 585395014782 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 585395014783 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 585395014784 Ca binding site [ion binding]; other site 585395014785 active site 585395014786 catalytic site [active] 585395014787 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 585395014788 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585395014789 active site turn [active] 585395014790 phosphorylation site [posttranslational modification] 585395014791 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585395014792 trehalose repressor; Provisional; Region: treR; PRK09492 585395014793 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585395014794 DNA binding site [nucleotide binding] 585395014795 domain linker motif; other site 585395014796 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 585395014797 dimerization interface [polypeptide binding]; other site 585395014798 ligand binding site [chemical binding]; other site 585395014799 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 585395014800 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 585395014801 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585395014802 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 585395014803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395014804 motif II; other site 585395014805 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 585395014806 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 585395014807 DNA-binding interface [nucleotide binding]; DNA binding site 585395014808 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585395014809 homotrimer interaction site [polypeptide binding]; other site 585395014810 putative active site [active] 585395014811 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 585395014812 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 585395014813 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 585395014814 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 585395014815 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585395014816 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585395014817 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 585395014818 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 585395014819 homotrimer interaction site [polypeptide binding]; other site 585395014820 putative active site [active] 585395014821 oxidoreductase; Provisional; Region: PRK12742 585395014822 classical (c) SDRs; Region: SDR_c; cd05233 585395014823 NAD(P) binding site [chemical binding]; other site 585395014824 active site 585395014825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585395014826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585395014827 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 585395014828 conserved predicted protein, C-terminal part 585395014829 conserved predicted protein, C-terminal part 585395014830 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 585395014831 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585395014832 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585395014833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 585395014834 RNase E inhibitor protein; Provisional; Region: PRK11191 585395014835 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 585395014836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395014837 Coenzyme A binding pocket [chemical binding]; other site 585395014838 Predicted membrane protein [Function unknown]; Region: COG4269 585395014839 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 585395014840 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 585395014841 HIGH motif; other site 585395014842 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 585395014843 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 585395014844 active site 585395014845 KMSKS motif; other site 585395014846 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 585395014847 tRNA binding surface [nucleotide binding]; other site 585395014848 anticodon binding site; other site 585395014849 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 585395014850 DNA polymerase III subunit chi; Validated; Region: PRK05728 585395014851 multifunctional aminopeptidase A; Provisional; Region: PRK00913 585395014852 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 585395014853 interface (dimer of trimers) [polypeptide binding]; other site 585395014854 Substrate-binding/catalytic site; other site 585395014855 Zn-binding sites [ion binding]; other site 585395014856 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 585395014857 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585395014858 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 585395014859 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585395014860 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 585395014861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 585395014862 Walker A motif; other site 585395014863 ATP binding site [chemical binding]; other site 585395014864 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 585395014865 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 585395014866 putative NAD(P) binding site [chemical binding]; other site 585395014867 putative substrate binding site [chemical binding]; other site 585395014868 catalytic Zn binding site [ion binding]; other site 585395014869 structural Zn binding site [ion binding]; other site 585395014870 dimer interface [polypeptide binding]; other site 585395014871 Integrative element ECO103_IE06 585395014872 integrase; Provisional; Region: PRK09692 585395014873 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585395014874 active site 585395014875 Int/Topo IB signature motif; other site 585395014876 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 585395014877 DGQHR domain; Region: DGQHR; TIGR03187 585395014878 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 585395014879 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395014880 ATP binding site [chemical binding]; other site 585395014881 putative Mg++ binding site [ion binding]; other site 585395014882 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 585395014883 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585395014884 ATP binding site [chemical binding]; other site 585395014885 putative Mg++ binding site [ion binding]; other site 585395014886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585395014887 nucleotide binding region [chemical binding]; other site 585395014888 ATP-binding site [chemical binding]; other site 585395014889 DEAD/DEAH box helicase; Region: DEAD; pfam00270 585395014890 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 585395014891 ATP binding site [chemical binding]; other site 585395014892 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 585395014893 putative Mg++ binding site [ion binding]; other site 585395014894 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 585395014895 ATP-binding site [chemical binding]; other site 585395014896 PLD-like domain; Region: PLDc_2; pfam13091 585395014897 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 585395014898 active site 585395014899 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585395014900 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 585395014901 Predicted GTPase [General function prediction only]; Region: COG3596 585395014902 YfjP GTPase; Region: YfjP; cd11383 585395014903 G1 box; other site 585395014904 GTP/Mg2+ binding site [chemical binding]; other site 585395014905 Switch I region; other site 585395014906 G2 box; other site 585395014907 Switch II region; other site 585395014908 G3 box; other site 585395014909 G4 box; other site 585395014910 G5 box; other site 585395014911 Predicted transcriptional regulator [Transcription]; Region: COG2378 585395014912 WYL domain; Region: WYL; pfam13280 585395014913 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585395014914 Antirestriction protein; Region: Antirestrict; pfam03230 585395014915 hypothetical protein; Reviewed; Region: PRK00024 585395014916 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585395014917 MPN+ (JAMM) motif; other site 585395014918 Zinc-binding site [ion binding]; other site 585395014919 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585395014920 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 585395014921 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 585395014922 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585395014923 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 585395014924 Kelch motif; Region: Kelch_1; pfam01344 585395014925 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 585395014926 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 585395014927 Int/Topo IB signature motif; other site 585395014928 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 585395014929 Int/Topo IB signature motif; other site 585395014930 Fimbrial protein; Region: Fimbrial; cl01416 585395014931 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585395014932 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 585395014933 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585395014934 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585395014935 outer membrane usher protein; Provisional; Region: PRK15193 585395014936 PapC N-terminal domain; Region: PapC_N; pfam13954 585395014937 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585395014938 PapC C-terminal domain; Region: PapC_C; pfam13953 585395014939 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585395014940 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585395014941 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 585395014942 mannosyl binding site [chemical binding]; other site 585395014943 Fimbrial protein; Region: Fimbrial; pfam00419 585395014944 fructuronate transporter; Provisional; Region: PRK10034 585395014945 gluconate transporter; Region: gntP; TIGR00791 585395014946 mannonate dehydratase; Region: uxuA; TIGR00695 585395014947 mannonate dehydratase; Provisional; Region: PRK03906 585395014948 D-mannonate oxidoreductase; Provisional; Region: PRK15037 585395014949 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585395014950 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585395014951 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 585395014952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395014953 DNA-binding site [nucleotide binding]; DNA binding site 585395014954 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585395014955 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 585395014956 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 585395014957 cell density-dependent motility repressor; Provisional; Region: PRK10082 585395014958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585395014959 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 585395014960 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 585395014961 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 585395014962 dimer interface [polypeptide binding]; other site 585395014963 active site 585395014964 hypothetical protein; Provisional; Region: PRK10519 585395014965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 585395014966 Nucleoside recognition; Region: Gate; pfam07670 585395014967 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 585395014968 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 585395014969 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 585395014970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 585395014971 SdiA-regulated; Region: SdiA-regulated; cd09971 585395014972 putative active site [active] 585395014973 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 585395014974 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 585395014975 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 585395014976 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 585395014977 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 585395014978 Predicted membrane protein [Function unknown]; Region: COG2733 585395014979 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 585395014980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395014981 putative substrate translocation pore; other site 585395014982 putative transposase; Provisional; Region: PRK09857 585395014983 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585395014984 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585395014985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395014986 DNA-binding site [nucleotide binding]; DNA binding site 585395014987 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585395014988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585395014989 homodimer interface [polypeptide binding]; other site 585395014990 catalytic residue [active] 585395014991 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 585395014992 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 585395014993 Penicillin amidase; Region: Penicil_amidase; pfam01804 585395014994 Penicillin G acylase (PGA) is the key enzyme in the industrial production of beta-lactam antibiotics. PGA hydrolyzes the side chain of penicillin G and related beta-lactam antibiotics releasing 6-amino penicillanic acid (6-APA), a building block in the...; Region: Ntn_PGA; cd03748 585395014995 active site 585395014996 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 585395014997 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 585395014998 P-loop, Walker A motif; other site 585395014999 Base recognition motif; other site 585395015000 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 585395015001 Uncharacterized small protein [Function unknown]; Region: COG2879 585395015002 carbon starvation protein A; Provisional; Region: PRK15015 585395015003 Carbon starvation protein CstA; Region: CstA; pfam02554 585395015004 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 585395015005 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 585395015006 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 585395015007 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 585395015008 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 585395015009 Cupin domain; Region: Cupin_2; pfam07883 585395015010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395015011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395015012 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 585395015013 putative substrate translocation pore; other site 585395015014 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 585395015015 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 585395015016 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 585395015017 putative substrate binding pocket [chemical binding]; other site 585395015018 trimer interface [polypeptide binding]; other site 585395015019 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 585395015020 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 585395015021 putative active site [active] 585395015022 putative metal binding site [ion binding]; other site 585395015023 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 585395015024 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 585395015025 NAD binding site [chemical binding]; other site 585395015026 catalytic residues [active] 585395015027 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 585395015028 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 585395015029 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 585395015030 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 585395015031 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585395015032 methyl-accepting chemotaxis protein I, serine sensor receptor, N-terminal part 585395015033 methyl-accepting chemotaxis protein I, serine sensor receptor, C-terminal 585395015034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585395015035 D-galactonate transporter; Region: 2A0114; TIGR00893 585395015036 putative substrate translocation pore; other site 585395015037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585395015038 DNA-binding site [nucleotide binding]; DNA binding site 585395015039 Transcriptional regulators [Transcription]; Region: GntR; COG1802 585395015040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 585395015041 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585395015042 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585395015043 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 585395015044 putative NAD(P) binding site [chemical binding]; other site 585395015045 catalytic Zn binding site [ion binding]; other site 585395015046 structural Zn binding site [ion binding]; other site 585395015047 phosphoglycerol transferase I; Provisional; Region: PRK03776 585395015048 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 585395015049 hypothetical protein; Provisional; Region: PRK11667 585395015050 DNA replication protein DnaC; Validated; Region: PRK07952 585395015051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585395015052 Walker A motif; other site 585395015053 ATP binding site [chemical binding]; other site 585395015054 Walker B motif; other site 585395015055 primosomal protein DnaI; Provisional; Region: PRK02854 585395015056 hypothetical protein; Provisional; Region: PRK09917 585395015057 Uncharacterized conserved protein [Function unknown]; Region: COG2966 585395015058 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 585395015059 predicted DNA-binding transcriptional regulator YjjQ, N-terminal part 585395015060 Transposase; Region: HTH_Tnp_1; cl17663 585395015061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395015062 putative transposase OrfB; Reviewed; Region: PHA02517 585395015063 HTH-like domain; Region: HTH_21; pfam13276 585395015064 Integrase core domain; Region: rve; pfam00665 585395015065 Integrase core domain; Region: rve_3; pfam13683 585395015066 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 585395015067 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585395015068 DNA binding residues [nucleotide binding] 585395015069 dimerization interface [polypeptide binding]; other site 585395015070 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 585395015071 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 585395015072 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 585395015073 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 585395015074 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 585395015075 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 585395015076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585395015077 S-adenosylmethionine binding site [chemical binding]; other site 585395015078 DNA polymerase III subunit psi; Validated; Region: PRK06856 585395015079 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 585395015080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585395015081 Coenzyme A binding pocket [chemical binding]; other site 585395015082 dUMP phosphatase; Provisional; Region: PRK09449 585395015083 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395015084 motif II; other site 585395015085 Prophage ECO103_P15, lambda-like phage 585395015086 integrase; Provisional; Region: PRK09692 585395015087 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585395015088 active site 585395015089 Int/Topo IB signature motif; other site 585395015090 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585395015091 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585395015092 DksA-like zinc finger domain containing protein; Region: PHA00080 585395015093 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 585395015094 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 585395015095 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 585395015096 phage recombination protein Bet; Region: bet_lambda; TIGR01913 585395015097 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 585395015098 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 585395015099 Catalytic domain of Protein Kinases; Region: PKc; cd00180 585395015100 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 585395015101 active site 585395015102 ATP binding site [chemical binding]; other site 585395015103 substrate binding site [chemical binding]; other site 585395015104 activation loop (A-loop); other site 585395015105 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 585395015106 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 585395015107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395015108 non-specific DNA binding site [nucleotide binding]; other site 585395015109 salt bridge; other site 585395015110 sequence-specific DNA binding site [nucleotide binding]; other site 585395015111 Predicted transcriptional regulator [Transcription]; Region: COG2932 585395015112 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585395015113 Catalytic site [active] 585395015114 Helix-turn-helix domain; Region: HTH_17; pfam12728 585395015115 Bacteriophage CII protein; Region: Phage_CII; pfam05269 585395015116 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 585395015117 Replication protein P; Region: Phage_lambda_P; pfam06992 585395015118 putative transposase OrfB; Reviewed; Region: PHA02517 585395015119 HTH-like domain; Region: HTH_21; pfam13276 585395015120 Integrase core domain; Region: rve; pfam00665 585395015121 Integrase core domain; Region: rve_3; pfam13683 585395015122 Transposase; Region: HTH_Tnp_1; cl17663 585395015123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395015124 Prophage ECO103_P15; conserved predicted protein, C-terminal part 585395015125 NinB protein; Region: NinB; pfam05772 585395015126 NUMOD4 motif; Region: NUMOD4; pfam07463 585395015127 HNH endonuclease; Region: HNH_3; pfam13392 585395015128 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 585395015129 ORF6N domain; Region: ORF6N; pfam10543 585395015130 Phage anti-repressor protein [Transcription]; Region: COG3561 585395015131 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 585395015132 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585395015133 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 585395015134 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 585395015135 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585395015136 Ribosome inactivating protein; Region: RIP; pfam00161 585395015137 Shiga-like toxin beta subunit; Region: SLT_beta; pfam02258 585395015138 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585395015139 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585395015140 Transposase; Region: HTH_Tnp_1; cl17663 585395015141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395015142 putative transposase OrfB; Reviewed; Region: PHA02517 585395015143 HTH-like domain; Region: HTH_21; pfam13276 585395015144 Integrase core domain; Region: rve; pfam00665 585395015145 Integrase core domain; Region: rve_3; pfam13683 585395015146 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585395015147 catalytic residues [active] 585395015148 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 585395015149 ORF11CD3 domain; Region: ORF11CD3; pfam10549 585395015150 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585395015151 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585395015152 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 585395015153 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 585395015154 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585395015155 active site 585395015156 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 585395015157 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 585395015158 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 585395015159 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 585395015160 Phage capsid family; Region: Phage_capsid; pfam05065 585395015161 Phage-related protein [Function unknown]; Region: COG4695 585395015162 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 585395015163 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 585395015164 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 585395015165 zinc binding site [ion binding]; other site 585395015166 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 585395015167 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 585395015168 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 585395015169 Immunoglobulin I-set domain; Region: I-set; pfam07679 585395015170 Immunoglobulin domain; Region: Ig_2; pfam13895 585395015171 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 585395015172 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 585395015173 Phage-related minor tail protein [Function unknown]; Region: COG5281 585395015174 tape measure domain; Region: tape_meas_nterm; TIGR02675 585395015175 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 585395015176 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585395015177 Phage-related protein [Function unknown]; Region: COG4718 585395015178 Phage-related protein [Function unknown]; Region: gp18; COG4672 585395015179 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585395015180 MPN+ (JAMM) motif; other site 585395015181 Zinc-binding site [ion binding]; other site 585395015182 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585395015183 NlpC/P60 family; Region: NLPC_P60; cl17555 585395015184 Phage-related protein, tail component [Function unknown]; Region: COG4723 585395015185 Phage-related protein, tail component [Function unknown]; Region: COG4733 585395015186 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585395015187 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585395015188 Interdomain contacts; other site 585395015189 Cytokine receptor motif; other site 585395015190 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585395015191 Fibronectin type III protein; Region: DUF3672; pfam12421 585395015192 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585395015193 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585395015194 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585395015195 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395015196 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585395015197 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585395015198 Prophage ECO103_P15; T3SS effector NleG-like protein, C-terminal part 585395015199 DinI-like family; Region: DinI; pfam06183 585395015200 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 585395015201 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 585395015202 G1 box; other site 585395015203 putative GEF interaction site [polypeptide binding]; other site 585395015204 GTP/Mg2+ binding site [chemical binding]; other site 585395015205 Switch I region; other site 585395015206 G2 box; other site 585395015207 G3 box; other site 585395015208 Switch II region; other site 585395015209 G4 box; other site 585395015210 G5 box; other site 585395015211 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 585395015212 periplasmic protein; Provisional; Region: PRK10568 585395015213 BON domain; Region: BON; pfam04972 585395015214 BON domain; Region: BON; pfam04972 585395015215 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 585395015216 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 585395015217 active site 585395015218 nucleophile elbow; other site 585395015219 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585395015220 active site 585395015221 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 585395015222 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585395015223 FeS/SAM binding site; other site 585395015224 hypothetical protein; Provisional; Region: PRK10977 585395015225 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 585395015226 intersubunit interface [polypeptide binding]; other site 585395015227 active site 585395015228 catalytic residue [active] 585395015229 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 585395015230 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585395015231 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 585395015232 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 585395015233 phosphopentomutase; Provisional; Region: PRK05362 585395015234 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 585395015235 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 585395015236 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 585395015237 conserved predicted protein, truncated 585395015238 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 585395015239 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 585395015240 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 585395015241 hypothetical protein; Provisional; Region: PRK11246 585395015242 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 585395015243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585395015244 motif II; other site 585395015245 DNA repair protein RadA; Region: sms; TIGR00416 585395015246 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 585395015247 Walker A motif/ATP binding site; other site 585395015248 ATP binding site [chemical binding]; other site 585395015249 Walker B motif; other site 585395015250 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 585395015251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585395015252 non-specific DNA binding site [nucleotide binding]; other site 585395015253 salt bridge; other site 585395015254 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 585395015255 sequence-specific DNA binding site [nucleotide binding]; other site 585395015256 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 585395015257 active site 585395015258 (T/H)XGH motif; other site 585395015259 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 585395015260 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 585395015261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585395015262 Walker A/P-loop; other site 585395015263 ATP binding site [chemical binding]; other site 585395015264 Q-loop/lid; other site 585395015265 ABC transporter signature motif; other site 585395015266 Walker B; other site 585395015267 D-loop; other site 585395015268 H-loop/switch region; other site 585395015269 ABC transporter; Region: ABC_tran_2; pfam12848 585395015270 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585395015271 lytic murein transglycosylase; Provisional; Region: PRK11619 585395015272 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585395015273 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585395015274 catalytic residue [active] 585395015275 Trp operon repressor; Provisional; Region: PRK01381 585395015276 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 585395015277 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585395015278 catalytic core [active] 585395015279 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 585395015280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585395015281 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 585395015282 hypothetical protein; Provisional; Region: PRK10756 585395015283 CreA protein; Region: CreA; pfam05981 585395015284 DNA-binding response regulator CreB; Provisional; Region: PRK11083 585395015285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395015286 active site 585395015287 phosphorylation site [posttranslational modification] 585395015288 intermolecular recognition site; other site 585395015289 dimerization interface [polypeptide binding]; other site 585395015290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395015291 DNA binding site [nucleotide binding] 585395015292 sensory histidine kinase CreC; Provisional; Region: PRK11100 585395015293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585395015294 dimerization interface [polypeptide binding]; other site 585395015295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585395015296 dimer interface [polypeptide binding]; other site 585395015297 phosphorylation site [posttranslational modification] 585395015298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585395015299 ATP binding site [chemical binding]; other site 585395015300 Mg2+ binding site [ion binding]; other site 585395015301 G-X-G motif; other site 585395015302 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 585395015303 two-component response regulator; Provisional; Region: PRK11173 585395015304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585395015305 active site 585395015306 phosphorylation site [posttranslational modification] 585395015307 intermolecular recognition site; other site 585395015308 dimerization interface [polypeptide binding]; other site 585395015309 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585395015310 DNA binding site [nucleotide binding] 585395015311 putative RNA methyltransferase; Provisional; Region: PRK10433 585395015312 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 585395015313 Peptidase M66; Region: Peptidase_M66; pfam10462 585395015314 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 585395015315 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 585395015316 type II secretion system protein D; Region: type_II_gspD; TIGR02517 585395015317 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585395015318 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585395015319 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585395015320 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 585395015321 type II secretion system protein E; Region: type_II_gspE; TIGR02533 585395015322 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 585395015323 Walker A motif; other site 585395015324 ATP binding site [chemical binding]; other site 585395015325 Walker B motif; other site 585395015326 type II secretion system protein F; Region: GspF; TIGR02120 585395015327 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585395015328 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585395015329 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 585395015330 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 585395015331 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 585395015332 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 585395015333 type II secretion system protein I; Region: gspI; TIGR01707 585395015334 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 585395015335 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 585395015336 type II secretion system protein J; Region: gspJ; TIGR01711 585395015337 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 585395015338 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 585395015339 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 585395015340 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 585395015341 GspL periplasmic domain; Region: GspL_C; pfam12693 585395015342 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 585395015343 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 585395015344 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 585395015345 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 585395015346 lipoprotein, PulS/OutS family; Region: PulS_OutS; TIGR01004 585395015347 predicted transposase OrfA protein of insertion sequence IS629, N-terminal fragment 585395015348 Transposase; Region: HTH_Tnp_1; cl17663 585395015349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395015350 putative transposase OrfB; Reviewed; Region: PHA02517 585395015351 HTH-like domain; Region: HTH_21; pfam13276 585395015352 Integrase core domain; Region: rve; pfam00665 585395015353 Integrase core domain; Region: rve_3; pfam13683 585395015354 probable recombinase, partial 585395015355 probable recombinase, partial 585395015356 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 585395015357 putative active site [active] 585395015358 putative metal binding site [ion binding]; other site 585395015359 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585395015360 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585395015361 hypothetical protein; Provisional; Region: PRK10649 585395015362 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585395015363 Sulfatase; Region: Sulfatase; pfam00884 585395015364 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585395015365 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585395015366 putative acyl-acceptor binding pocket; other site 585395015367 predicted protein Orf1 in insertion sequence ISEc8, N-terminal fragment 585395015368 putative transposase OrfB; Reviewed; Region: PHA02517 585395015369 HTH-like domain; Region: HTH_21; pfam13276 585395015370 Integrase core domain; Region: rve; pfam00665 585395015371 Integrase core domain; Region: rve_3; pfam13683 585395015372 Transposase; Region: HTH_Tnp_1; cl17663 585395015373 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395015374 YebF-like protein; Region: YebF; cl10126 585395015375 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 585395015376 HlyD family secretion protein; Region: HlyD_3; pfam13437 585395015377 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 585395015378 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 585395015379 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585395015380 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 585395015381 Walker A/P-loop; other site 585395015382 ATP binding site [chemical binding]; other site 585395015383 Q-loop/lid; other site 585395015384 ABC transporter signature motif; other site 585395015385 Walker B; other site 585395015386 D-loop; other site 585395015387 H-loop/switch region; other site 585395015388 RTX N-terminal domain; Region: RTX; pfam02382 585395015389 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 585395015390 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 585395015391 RTX C-terminal domain; Region: RTX_C; pfam08339 585395015392 RTX toxin acyltransferase family; Region: HlyC; pfam02794 585395015393 Transposase; Region: HTH_Tnp_1; cl17663 585395015394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395015395 putative transposase OrfB; Reviewed; Region: PHA02517 585395015396 HTH-like domain; Region: HTH_21; pfam13276 585395015397 Integrase core domain; Region: rve; pfam00665 585395015398 Integrase core domain; Region: rve_3; pfam13683 585395015399 predicted TraH protein, C-terminal part 585395015400 predicted TraG protein, N-terminal part 585395015401 predicted TraG protein, C-terminal part 585395015402 Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624 585395015403 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 585395015404 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 585395015405 putative transposase OrfB; Reviewed; Region: PHA02517 585395015406 HTH-like domain; Region: HTH_21; pfam13276 585395015407 Integrase core domain; Region: rve; pfam00665 585395015408 Integrase core domain; Region: rve_3; pfam13683 585395015409 Transposase; Region: HTH_Tnp_1; cl17663 585395015410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395015411 predicted TraD protein, N-terminal part 585395015412 predicted TraD protein, C-terminal part 585395015413 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 585395015414 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 585395015415 AAA domain; Region: AAA_30; pfam13604 585395015416 DNA helicase TraI; Region: TraI; pfam07057 585395015417 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 585395015418 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585395015419 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585395015420 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 585395015421 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 585395015422 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 585395015423 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 585395015424 putative RNA binding sites [nucleotide binding]; other site 585395015425 Staphylococcal nuclease homologues; Region: SNc; smart00318 585395015426 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 585395015427 Catalytic site; other site 585395015428 Haemolysin expression modulating protein; Region: HHA; pfam05321 585395015429 predicted transposase OrfB protein of insertion sequence IS911, central part 585395015430 putative transposase OrfB; Reviewed; Region: PHA02517 585395015431 HTH-like domain; Region: HTH_21; pfam13276 585395015432 Integrase core domain; Region: rve; pfam00665 585395015433 Integrase core domain; Region: rve_3; pfam13683 585395015434 Transposase; Region: HTH_Tnp_1; cl17663 585395015435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585395015436 predicted regulatory protein OrfA of insertion sequence IS911, N-terminal part 585395015437 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 585395015438 conserved predicted protein, partial 585395015439 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 585395015440 active site 585395015441 catalytic residues [active] 585395015442 DNA binding site [nucleotide binding] 585395015443 Int/Topo IB signature motif; other site 585395015444 predicted transposase, partial 585395015445 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 585395015446 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 585395015447 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 585395015448 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 585395015449 P-loop; other site 585395015450 Magnesium ion binding site [ion binding]; other site 585395015451 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585395015452 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 585395015453 ParB-like nuclease domain; Region: ParB; smart00470 585395015454 ParB family; Region: ParB; pfam08775 585395015455 predicted DNA polymerase V, subunit C UmuC, C-terminal part 585395015456 predicted DNA polymerase V, subunit C UmuC-like protein, partial 585395015457 conserved predicted protein, C-terminal part 585395015458 putative adenine-specific DNA methylase, partial 585395015459 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 585395015460 conserved predicted protein, C-terminal part 585395015461 Antirestriction protein; Region: Antirestrict; pfam03230 585395015462 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 585395015463 conserved predicted protein, N-terminal part 585395015464 conserved predicted protein, N-terminal part 585395015465 conserved predicted protein, C-terminal part 585395015466 predicted protein in insertion sequence IS4 family IS element, N-terminal fragment 585395015467 predicted protein in insertion sequence IS4 family IS element, C-terminal fragment 585395015468 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 585395015469 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585395015470 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585395015471 catalytic residue [active] 585395015472 TraM protein; Region: Tra_M; pfam05261 585395015473 putative transposase OrfB; Reviewed; Region: PHA02517 585395015474 HTH-like domain; Region: HTH_21; pfam13276 585395015475 Integrase core domain; Region: rve; pfam00665 585395015476 Integrase core domain; Region: rve_3; pfam13683 585395015477 Transposase; Region: HTH_Tnp_1; cl17663 585395015478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963