-- dump date 20140619_085537 -- class Genbank::misc_feature -- table misc_feature_note -- id note 585396000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 585396000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 585396000003 putative catalytic residues [active] 585396000004 putative nucleotide binding site [chemical binding]; other site 585396000005 putative aspartate binding site [chemical binding]; other site 585396000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 585396000007 dimer interface [polypeptide binding]; other site 585396000008 putative threonine allosteric regulatory site; other site 585396000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 585396000010 putative threonine allosteric regulatory site; other site 585396000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 585396000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 585396000013 homoserine kinase; Region: thrB; TIGR00191 585396000014 Protein of unknown function; Region: YhfT; pfam10797 585396000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585396000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 585396000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 585396000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396000019 catalytic residue [active] 585396000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 585396000021 hypothetical protein; Validated; Region: PRK02101 585396000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 585396000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 585396000024 transaldolase-like protein; Provisional; Region: PTZ00411 585396000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 585396000026 active site 585396000027 dimer interface [polypeptide binding]; other site 585396000028 catalytic residue [active] 585396000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 585396000030 MPT binding site; other site 585396000031 trimer interface [polypeptide binding]; other site 585396000032 hypothetical protein; Provisional; Region: PRK10659 585396000033 hypothetical protein; Provisional; Region: PRK10236 585396000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 585396000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 585396000036 hypothetical protein; Provisional; Region: PRK10154 585396000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 585396000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 585396000039 nucleotide binding site [chemical binding]; other site 585396000040 NEF interaction site [polypeptide binding]; other site 585396000041 SBD interface [polypeptide binding]; other site 585396000042 chaperone protein DnaJ; Provisional; Region: PRK10767 585396000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585396000044 HSP70 interaction site [polypeptide binding]; other site 585396000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 585396000046 substrate binding site [polypeptide binding]; other site 585396000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585396000048 Zn binding sites [ion binding]; other site 585396000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 585396000050 dimer interface [polypeptide binding]; other site 585396000051 Hok/gef family; Region: HOK_GEF; pfam01848 585396000052 Hok/gef family; Region: HOK_GEF; pfam01848 585396000053 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 585396000054 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 585396000055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396000056 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 585396000057 putative dimerization interface [polypeptide binding]; other site 585396000058 conserved predicted protein, C-terminal part 585396000059 conserved predicted protein (pseudogene by frame shift mutation) 585396000060 putative outer membrane usher protein precursor, C-terminal part 585396000061 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 585396000062 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 585396000063 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 585396000064 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 585396000065 active site 585396000066 Riboflavin kinase; Region: Flavokinase; smart00904 585396000067 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 585396000068 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 585396000069 HIGH motif; other site 585396000070 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 585396000071 active site 585396000072 KMSKS motif; other site 585396000073 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 585396000074 tRNA binding surface [nucleotide binding]; other site 585396000075 anticodon binding site; other site 585396000076 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585396000077 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 585396000078 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 585396000079 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585396000080 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 585396000081 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 585396000082 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585396000083 active site 585396000084 tetramer interface [polypeptide binding]; other site 585396000085 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 585396000086 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 585396000087 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 585396000088 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 585396000089 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 585396000090 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 585396000091 catalytic site [active] 585396000092 subunit interface [polypeptide binding]; other site 585396000093 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 585396000094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585396000095 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 585396000096 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 585396000097 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585396000098 ATP-grasp domain; Region: ATP-grasp_4; cl17255 585396000099 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 585396000100 IMP binding site; other site 585396000101 dimer interface [polypeptide binding]; other site 585396000102 interdomain contacts; other site 585396000103 partial ornithine binding site; other site 585396000104 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 585396000105 carnitine operon protein CaiE; Provisional; Region: PRK13627 585396000106 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 585396000107 putative trimer interface [polypeptide binding]; other site 585396000108 putative metal binding site [ion binding]; other site 585396000109 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 585396000110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585396000111 substrate binding site [chemical binding]; other site 585396000112 oxyanion hole (OAH) forming residues; other site 585396000113 trimer interface [polypeptide binding]; other site 585396000114 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 585396000115 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 585396000116 acyl-activating enzyme (AAE) consensus motif; other site 585396000117 putative AMP binding site [chemical binding]; other site 585396000118 putative active site [active] 585396000119 putative CoA binding site [chemical binding]; other site 585396000120 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 585396000121 CoA-transferase family III; Region: CoA_transf_3; pfam02515 585396000122 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 585396000123 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 585396000124 active site 585396000125 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 585396000126 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 585396000127 Ligand binding site [chemical binding]; other site 585396000128 Electron transfer flavoprotein domain; Region: ETF; pfam01012 585396000129 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 585396000130 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 585396000131 Ligand binding site [chemical binding]; other site 585396000132 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 585396000133 putative oxidoreductase FixC; Provisional; Region: PRK10157 585396000134 ferredoxin-like protein FixX; Provisional; Region: PRK15449 585396000135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396000136 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 585396000137 putative substrate translocation pore; other site 585396000138 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 585396000139 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 585396000140 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 585396000141 TrkA-N domain; Region: TrkA_N; pfam02254 585396000142 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 585396000143 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 585396000144 folate binding site [chemical binding]; other site 585396000145 NADP+ binding site [chemical binding]; other site 585396000146 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 585396000147 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 585396000148 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 585396000149 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 585396000150 active site 585396000151 metal binding site [ion binding]; metal-binding site 585396000152 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 585396000153 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 585396000154 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 585396000155 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 585396000156 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 585396000157 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 585396000158 SurA N-terminal domain; Region: SurA_N; pfam09312 585396000159 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 585396000160 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 585396000161 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 585396000162 OstA-like protein; Region: OstA; pfam03968 585396000163 Organic solvent tolerance protein; Region: OstA_C; pfam04453 585396000164 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 585396000165 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 585396000166 putative metal binding site [ion binding]; other site 585396000167 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585396000168 HSP70 interaction site [polypeptide binding]; other site 585396000169 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 585396000170 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585396000171 active site 585396000172 ATP-dependent helicase HepA; Validated; Region: PRK04914 585396000173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585396000174 ATP binding site [chemical binding]; other site 585396000175 putative Mg++ binding site [ion binding]; other site 585396000176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396000177 nucleotide binding region [chemical binding]; other site 585396000178 ATP-binding site [chemical binding]; other site 585396000179 DNA polymerase II; Reviewed; Region: PRK05762 585396000180 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 585396000181 active site 585396000182 catalytic site [active] 585396000183 substrate binding site [chemical binding]; other site 585396000184 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 585396000185 active site 585396000186 metal-binding site 585396000187 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585396000188 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585396000189 intersubunit interface [polypeptide binding]; other site 585396000190 active site 585396000191 Zn2+ binding site [ion binding]; other site 585396000192 L-arabinose isomerase; Provisional; Region: PRK02929 585396000193 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 585396000194 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 585396000195 trimer interface [polypeptide binding]; other site 585396000196 putative substrate binding site [chemical binding]; other site 585396000197 putative metal binding site [ion binding]; other site 585396000198 ribulokinase; Provisional; Region: PRK04123 585396000199 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 585396000200 N- and C-terminal domain interface [polypeptide binding]; other site 585396000201 active site 585396000202 MgATP binding site [chemical binding]; other site 585396000203 catalytic site [active] 585396000204 metal binding site [ion binding]; metal-binding site 585396000205 carbohydrate binding site [chemical binding]; other site 585396000206 homodimer interface [polypeptide binding]; other site 585396000207 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 585396000208 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585396000209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396000210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396000211 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585396000212 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585396000213 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 585396000214 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 585396000215 Walker A/P-loop; other site 585396000216 ATP binding site [chemical binding]; other site 585396000217 Q-loop/lid; other site 585396000218 ABC transporter signature motif; other site 585396000219 Walker B; other site 585396000220 D-loop; other site 585396000221 H-loop/switch region; other site 585396000222 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 585396000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396000224 dimer interface [polypeptide binding]; other site 585396000225 conserved gate region; other site 585396000226 putative PBP binding loops; other site 585396000227 ABC-ATPase subunit interface; other site 585396000228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396000229 dimer interface [polypeptide binding]; other site 585396000230 conserved gate region; other site 585396000231 putative PBP binding loops; other site 585396000232 ABC-ATPase subunit interface; other site 585396000233 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 585396000234 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 585396000235 transcriptional regulator SgrR; Provisional; Region: PRK13626 585396000236 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 585396000237 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 585396000238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396000239 sugar efflux transporter; Region: 2A0120; TIGR00899 585396000240 putative substrate translocation pore; other site 585396000241 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 585396000242 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 585396000243 substrate binding site [chemical binding]; other site 585396000244 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 585396000245 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 585396000246 substrate binding site [chemical binding]; other site 585396000247 ligand binding site [chemical binding]; other site 585396000248 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 585396000249 tartrate dehydrogenase; Region: TTC; TIGR02089 585396000250 2-isopropylmalate synthase; Validated; Region: PRK00915 585396000251 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 585396000252 active site 585396000253 catalytic residues [active] 585396000254 metal binding site [ion binding]; metal-binding site 585396000255 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 585396000256 leu operon leader peptide; Provisional; Region: PRK09925 585396000257 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 585396000258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396000259 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 585396000260 putative substrate binding pocket [chemical binding]; other site 585396000261 putative dimerization interface [polypeptide binding]; other site 585396000262 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 585396000263 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585396000264 PYR/PP interface [polypeptide binding]; other site 585396000265 dimer interface [polypeptide binding]; other site 585396000266 TPP binding site [chemical binding]; other site 585396000267 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585396000268 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585396000269 TPP-binding site [chemical binding]; other site 585396000270 dimer interface [polypeptide binding]; other site 585396000271 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 585396000272 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 585396000273 putative valine binding site [chemical binding]; other site 585396000274 dimer interface [polypeptide binding]; other site 585396000275 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 585396000276 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 585396000277 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396000278 DNA binding site [nucleotide binding] 585396000279 domain linker motif; other site 585396000280 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 585396000281 dimerization interface [polypeptide binding]; other site 585396000282 ligand binding site [chemical binding]; other site 585396000283 mraZ protein; Region: TIGR00242 585396000284 MraZ protein; Region: MraZ; pfam02381 585396000285 MraZ protein; Region: MraZ; pfam02381 585396000286 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 585396000287 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 585396000288 cell division protein FtsL; Provisional; Region: PRK10772 585396000289 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 585396000290 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 585396000291 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 585396000292 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 585396000293 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585396000294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585396000295 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585396000296 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 585396000297 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585396000298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585396000299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585396000300 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 585396000301 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 585396000302 Mg++ binding site [ion binding]; other site 585396000303 putative catalytic motif [active] 585396000304 putative substrate binding site [chemical binding]; other site 585396000305 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 585396000306 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585396000307 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585396000308 cell division protein FtsW; Provisional; Region: PRK10774 585396000309 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 585396000310 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 585396000311 active site 585396000312 homodimer interface [polypeptide binding]; other site 585396000313 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 585396000314 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585396000315 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585396000316 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585396000317 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 585396000318 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 585396000319 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 585396000320 cell division protein FtsQ; Provisional; Region: PRK10775 585396000321 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 585396000322 Cell division protein FtsQ; Region: FtsQ; pfam03799 585396000323 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 585396000324 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585396000325 Cell division protein FtsA; Region: FtsA; pfam14450 585396000326 cell division protein FtsZ; Validated; Region: PRK09330 585396000327 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 585396000328 nucleotide binding site [chemical binding]; other site 585396000329 SulA interaction site; other site 585396000330 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 585396000331 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 585396000332 SecA regulator SecM; Provisional; Region: PRK02943 585396000333 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 585396000334 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 585396000335 SEC-C motif; Region: SEC-C; pfam02810 585396000336 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 585396000337 active site 585396000338 8-oxo-dGMP binding site [chemical binding]; other site 585396000339 nudix motif; other site 585396000340 metal binding site [ion binding]; metal-binding site 585396000341 DNA gyrase inhibitor; Reviewed; Region: PRK00418 585396000342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 585396000343 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 585396000344 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 585396000345 CoA-binding site [chemical binding]; other site 585396000346 ATP-binding [chemical binding]; other site 585396000347 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 585396000348 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 585396000349 active site 585396000350 type IV pilin biogenesis protein; Provisional; Region: PRK10573 585396000351 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585396000352 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585396000353 hypothetical protein; Provisional; Region: PRK10436 585396000354 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 585396000355 Walker A motif; other site 585396000356 ATP binding site [chemical binding]; other site 585396000357 Walker B motif; other site 585396000358 putative major pilin subunit; Provisional; Region: PRK10574 585396000359 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585396000360 Pilin (bacterial filament); Region: Pilin; pfam00114 585396000361 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 585396000362 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 585396000363 dimerization interface [polypeptide binding]; other site 585396000364 active site 585396000365 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 585396000366 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 585396000367 amidase catalytic site [active] 585396000368 Zn binding residues [ion binding]; other site 585396000369 substrate binding site [chemical binding]; other site 585396000370 regulatory protein AmpE; Provisional; Region: PRK10987 585396000371 aromatic amino acid transporter; Provisional; Region: PRK10238 585396000372 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585396000373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396000374 DNA-binding site [nucleotide binding]; DNA binding site 585396000375 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585396000376 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 585396000377 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 585396000378 dimer interface [polypeptide binding]; other site 585396000379 TPP-binding site [chemical binding]; other site 585396000380 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 585396000381 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585396000382 E3 interaction surface; other site 585396000383 lipoyl attachment site [posttranslational modification]; other site 585396000384 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585396000385 E3 interaction surface; other site 585396000386 lipoyl attachment site [posttranslational modification]; other site 585396000387 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585396000388 E3 interaction surface; other site 585396000389 lipoyl attachment site [posttranslational modification]; other site 585396000390 e3 binding domain; Region: E3_binding; pfam02817 585396000391 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 585396000392 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 585396000393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585396000394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396000395 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585396000396 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 585396000397 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 585396000398 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 585396000399 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 585396000400 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 585396000401 substrate binding site [chemical binding]; other site 585396000402 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 585396000403 substrate binding site [chemical binding]; other site 585396000404 ligand binding site [chemical binding]; other site 585396000405 hypothetical protein; Provisional; Region: PRK05248 585396000406 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 585396000407 spermidine synthase; Provisional; Region: PRK00811 585396000408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396000409 S-adenosylmethionine binding site [chemical binding]; other site 585396000410 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 585396000411 multicopper oxidase; Provisional; Region: PRK10965 585396000412 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 585396000413 Multicopper oxidase; Region: Cu-oxidase; pfam00394 585396000414 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 585396000415 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 585396000416 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 585396000417 Trp docking motif [polypeptide binding]; other site 585396000418 putative active site [active] 585396000419 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585396000420 active site 585396000421 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 585396000422 active site clefts [active] 585396000423 zinc binding site [ion binding]; other site 585396000424 dimer interface [polypeptide binding]; other site 585396000425 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 585396000426 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585396000427 Walker A/P-loop; other site 585396000428 ATP binding site [chemical binding]; other site 585396000429 Q-loop/lid; other site 585396000430 ABC transporter signature motif; other site 585396000431 Walker B; other site 585396000432 D-loop; other site 585396000433 H-loop/switch region; other site 585396000434 inner membrane transport permease; Provisional; Region: PRK15066 585396000435 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585396000436 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585396000437 active pocket/dimerization site; other site 585396000438 active site 585396000439 phosphorylation site [posttranslational modification] 585396000440 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 585396000441 putative active site [active] 585396000442 putative metal binding site [ion binding]; other site 585396000443 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 585396000444 tetramerization interface [polypeptide binding]; other site 585396000445 active site 585396000446 Uncharacterized conserved protein [Function unknown]; Region: COG5464 585396000447 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585396000448 pantoate--beta-alanine ligase; Region: panC; TIGR00018 585396000449 Pantoate-beta-alanine ligase; Region: PanC; cd00560 585396000450 active site 585396000451 ATP-binding site [chemical binding]; other site 585396000452 pantoate-binding site; other site 585396000453 HXXH motif; other site 585396000454 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 585396000455 oligomerization interface [polypeptide binding]; other site 585396000456 active site 585396000457 metal binding site [ion binding]; metal-binding site 585396000458 putative fimbrial-like protein yadC, C-terminal part 585396000459 putative fimbrial-like protein yadC, N-terminal part 585396000460 putative fimbrial protein StaF; Provisional; Region: PRK15262 585396000461 putative fimbrial protein StaE; Provisional; Region: PRK15263 585396000462 Fimbrial protein; Region: Fimbrial; cl01416 585396000463 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 585396000464 PapC N-terminal domain; Region: PapC_N; pfam13954 585396000465 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585396000466 PapC C-terminal domain; Region: PapC_C; pfam13953 585396000467 putative chaperone protein EcpD; Provisional; Region: PRK09926 585396000468 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585396000469 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585396000470 Fimbrial protein; Region: Fimbrial; cl01416 585396000471 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 585396000472 catalytic center binding site [active] 585396000473 ATP binding site [chemical binding]; other site 585396000474 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 585396000475 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 585396000476 active site 585396000477 NTP binding site [chemical binding]; other site 585396000478 metal binding triad [ion binding]; metal-binding site 585396000479 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 585396000480 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 585396000481 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 585396000482 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 585396000483 active site 585396000484 nucleotide binding site [chemical binding]; other site 585396000485 HIGH motif; other site 585396000486 KMSKS motif; other site 585396000487 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 585396000488 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 585396000489 2'-5' RNA ligase; Provisional; Region: PRK15124 585396000490 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 585396000491 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 585396000492 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 585396000493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585396000494 ATP binding site [chemical binding]; other site 585396000495 putative Mg++ binding site [ion binding]; other site 585396000496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396000497 nucleotide binding region [chemical binding]; other site 585396000498 ATP-binding site [chemical binding]; other site 585396000499 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 585396000500 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 585396000501 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 585396000502 Transglycosylase; Region: Transgly; pfam00912 585396000503 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585396000504 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 585396000505 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585396000506 N-terminal plug; other site 585396000507 ligand-binding site [chemical binding]; other site 585396000508 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 585396000509 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585396000510 Walker A/P-loop; other site 585396000511 ATP binding site [chemical binding]; other site 585396000512 Q-loop/lid; other site 585396000513 ABC transporter signature motif; other site 585396000514 Walker B; other site 585396000515 D-loop; other site 585396000516 H-loop/switch region; other site 585396000517 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 585396000518 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 585396000519 siderophore binding site; other site 585396000520 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585396000521 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585396000522 ABC-ATPase subunit interface; other site 585396000523 dimer interface [polypeptide binding]; other site 585396000524 putative PBP binding regions; other site 585396000525 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585396000526 ABC-ATPase subunit interface; other site 585396000527 dimer interface [polypeptide binding]; other site 585396000528 putative PBP binding regions; other site 585396000529 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 585396000530 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585396000531 inhibitor-cofactor binding pocket; inhibition site 585396000532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396000533 catalytic residue [active] 585396000534 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585396000535 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 585396000536 Cl- selectivity filter; other site 585396000537 Cl- binding residues [ion binding]; other site 585396000538 pore gating glutamate residue; other site 585396000539 dimer interface [polypeptide binding]; other site 585396000540 H+/Cl- coupling transport residue; other site 585396000541 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 585396000542 hypothetical protein; Provisional; Region: PRK10578 585396000543 UPF0126 domain; Region: UPF0126; pfam03458 585396000544 UPF0126 domain; Region: UPF0126; pfam03458 585396000545 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 585396000546 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 585396000547 cobalamin binding residues [chemical binding]; other site 585396000548 putative BtuC binding residues; other site 585396000549 dimer interface [polypeptide binding]; other site 585396000550 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 585396000551 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 585396000552 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 585396000553 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585396000554 Zn2+ binding site [ion binding]; other site 585396000555 Mg2+ binding site [ion binding]; other site 585396000556 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 585396000557 serine endoprotease; Provisional; Region: PRK10942 585396000558 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585396000559 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585396000560 protein binding site [polypeptide binding]; other site 585396000561 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585396000562 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 585396000563 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 585396000564 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 585396000565 hypothetical protein; Provisional; Region: PRK13677 585396000566 phosphodiesterase YaeI; Provisional; Region: PRK11340 585396000567 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 585396000568 putative active site [active] 585396000569 putative metal binding site [ion binding]; other site 585396000570 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 585396000571 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 585396000572 trimer interface [polypeptide binding]; other site 585396000573 active site 585396000574 substrate binding site [chemical binding]; other site 585396000575 CoA binding site [chemical binding]; other site 585396000576 PII uridylyl-transferase; Provisional; Region: PRK05007 585396000577 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585396000578 metal binding triad; other site 585396000579 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585396000580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585396000581 Zn2+ binding site [ion binding]; other site 585396000582 Mg2+ binding site [ion binding]; other site 585396000583 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 585396000584 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 585396000585 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 585396000586 active site 585396000587 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 585396000588 rRNA interaction site [nucleotide binding]; other site 585396000589 S8 interaction site; other site 585396000590 putative laminin-1 binding site; other site 585396000591 elongation factor Ts; Provisional; Region: tsf; PRK09377 585396000592 UBA/TS-N domain; Region: UBA; pfam00627 585396000593 Elongation factor TS; Region: EF_TS; pfam00889 585396000594 Elongation factor TS; Region: EF_TS; pfam00889 585396000595 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 585396000596 putative nucleotide binding site [chemical binding]; other site 585396000597 uridine monophosphate binding site [chemical binding]; other site 585396000598 homohexameric interface [polypeptide binding]; other site 585396000599 ribosome recycling factor; Reviewed; Region: frr; PRK00083 585396000600 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 585396000601 hinge region; other site 585396000602 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 585396000603 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 585396000604 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 585396000605 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 585396000606 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 585396000607 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 585396000608 catalytic residue [active] 585396000609 putative FPP diphosphate binding site; other site 585396000610 putative FPP binding hydrophobic cleft; other site 585396000611 dimer interface [polypeptide binding]; other site 585396000612 putative IPP diphosphate binding site; other site 585396000613 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 585396000614 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 585396000615 zinc metallopeptidase RseP; Provisional; Region: PRK10779 585396000616 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 585396000617 active site 585396000618 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 585396000619 protein binding site [polypeptide binding]; other site 585396000620 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 585396000621 putative substrate binding region [chemical binding]; other site 585396000622 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 585396000623 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585396000624 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585396000625 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585396000626 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585396000627 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585396000628 Surface antigen; Region: Bac_surface_Ag; pfam01103 585396000629 periplasmic chaperone; Provisional; Region: PRK10780 585396000630 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 585396000631 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 585396000632 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 585396000633 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 585396000634 trimer interface [polypeptide binding]; other site 585396000635 active site 585396000636 UDP-GlcNAc binding site [chemical binding]; other site 585396000637 lipid binding site [chemical binding]; lipid-binding site 585396000638 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 585396000639 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 585396000640 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 585396000641 active site 585396000642 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 585396000643 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 585396000644 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 585396000645 RNA/DNA hybrid binding site [nucleotide binding]; other site 585396000646 active site 585396000647 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 585396000648 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 585396000649 putative active site [active] 585396000650 putative PHP Thumb interface [polypeptide binding]; other site 585396000651 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 585396000652 generic binding surface II; other site 585396000653 generic binding surface I; other site 585396000654 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 585396000655 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 585396000656 lysine decarboxylase LdcC; Provisional; Region: PRK15399 585396000657 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585396000658 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585396000659 homodimer interface [polypeptide binding]; other site 585396000660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396000661 catalytic residue [active] 585396000662 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585396000663 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 585396000664 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585396000665 putative metal binding site [ion binding]; other site 585396000666 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 585396000667 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 585396000668 Ligand Binding Site [chemical binding]; other site 585396000669 TilS substrate binding domain; Region: TilS; pfam09179 585396000670 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 585396000671 Rho-binding antiterminator; Provisional; Region: PRK11625 585396000672 hypothetical protein; Provisional; Region: PRK04964 585396000673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 585396000674 hypothetical protein; Provisional; Region: PRK09256 585396000675 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 585396000676 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 585396000677 NlpE N-terminal domain; Region: NlpE; pfam04170 585396000678 predicted lipoprotein, C-terminal part 585396000679 predicted lipoprotein, N-terminal part 585396000680 prolyl-tRNA synthetase; Provisional; Region: PRK09194 585396000681 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 585396000682 dimer interface [polypeptide binding]; other site 585396000683 motif 1; other site 585396000684 active site 585396000685 motif 2; other site 585396000686 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 585396000687 putative deacylase active site [active] 585396000688 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 585396000689 active site 585396000690 motif 3; other site 585396000691 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 585396000692 anticodon binding site; other site 585396000693 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 585396000694 homodimer interaction site [polypeptide binding]; other site 585396000695 cofactor binding site; other site 585396000696 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 585396000697 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 585396000698 lipoprotein, YaeC family; Region: TIGR00363 585396000699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396000700 dimer interface [polypeptide binding]; other site 585396000701 conserved gate region; other site 585396000702 ABC-ATPase subunit interface; other site 585396000703 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 585396000704 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 585396000705 Walker A/P-loop; other site 585396000706 ATP binding site [chemical binding]; other site 585396000707 Q-loop/lid; other site 585396000708 ABC transporter signature motif; other site 585396000709 Walker B; other site 585396000710 D-loop; other site 585396000711 H-loop/switch region; other site 585396000712 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 585396000713 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 585396000714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396000715 active site 585396000716 motif I; other site 585396000717 motif II; other site 585396000718 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585396000719 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585396000720 active site 585396000721 catalytic tetrad [active] 585396000722 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585396000723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396000724 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 585396000725 putative effector binding pocket; other site 585396000726 dimerization interface [polypeptide binding]; other site 585396000727 hypothetical protein; Provisional; Region: PRK05421 585396000728 putative catalytic site [active] 585396000729 putative metal binding site [ion binding]; other site 585396000730 putative phosphate binding site [ion binding]; other site 585396000731 putative catalytic site [active] 585396000732 putative phosphate binding site [ion binding]; other site 585396000733 putative metal binding site [ion binding]; other site 585396000734 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585396000735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396000736 S-adenosylmethionine binding site [chemical binding]; other site 585396000737 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 585396000738 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585396000739 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585396000740 catalytic residue [active] 585396000741 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585396000742 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585396000743 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 585396000744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396000745 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 585396000746 RNA/DNA hybrid binding site [nucleotide binding]; other site 585396000747 active site 585396000748 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 585396000749 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 585396000750 active site 585396000751 catalytic site [active] 585396000752 substrate binding site [chemical binding]; other site 585396000753 putative aminopeptidase, N-terminal part 585396000754 putative aminopeptidase, C-terminal part 585396000755 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585396000756 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 585396000757 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585396000758 ImpA domain protein; Region: DUF3702; pfam12486 585396000759 IcmF-like protein, C-terminal part 585396000760 IcmF-like protein, N-terminal part 585396000761 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585396000762 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 585396000763 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 585396000764 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 585396000765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396000766 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 585396000767 Walker A motif; other site 585396000768 ATP binding site [chemical binding]; other site 585396000769 Walker B motif; other site 585396000770 arginine finger; other site 585396000771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396000772 Walker A motif; other site 585396000773 ATP binding site [chemical binding]; other site 585396000774 Walker B motif; other site 585396000775 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585396000776 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 585396000777 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 585396000778 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 585396000779 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 585396000780 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 585396000781 conserved predicted protein, C-terminal part 585396000782 conserved predicted protein, N-terminal part 585396000783 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 585396000784 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 585396000785 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 585396000786 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 585396000787 Protein of unknown function (DUF877); Region: DUF877; pfam05943 585396000788 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 585396000789 Protein of unknown function (DUF770); Region: DUF770; pfam05591 585396000790 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585396000791 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 585396000792 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585396000793 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585396000794 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585396000795 PAAR motif; Region: PAAR_motif; cl15808 585396000796 RHS Repeat; Region: RHS_repeat; pfam05593 585396000797 RHS Repeat; Region: RHS_repeat; cl11982 585396000798 RHS Repeat; Region: RHS_repeat; cl11982 585396000799 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585396000800 RHS Repeat; Region: RHS_repeat; pfam05593 585396000801 RHS Repeat; Region: RHS_repeat; cl11982 585396000802 RHS Repeat; Region: RHS_repeat; pfam05593 585396000803 RHS protein; Region: RHS; pfam03527 585396000804 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585396000805 RhsI, IS677, putative H repeat-associated protein, N-terminal fragment 585396000806 RhsG, IS677, putative H repeat-associated protein, N-terminal part truncated 585396000807 C-N hydrolase family amidase; Provisional; Region: PRK10438 585396000808 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 585396000809 putative active site [active] 585396000810 catalytic triad [active] 585396000811 dimer interface [polypeptide binding]; other site 585396000812 multimer interface [polypeptide binding]; other site 585396000813 C-lysozyme inhibitor; Provisional; Region: PRK09993 585396000814 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 585396000815 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 585396000816 active site 585396000817 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 585396000818 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 585396000819 dimer interface [polypeptide binding]; other site 585396000820 active site 585396000821 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 585396000822 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 585396000823 putative active site [active] 585396000824 putative dimer interface [polypeptide binding]; other site 585396000825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 585396000826 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585396000827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 585396000828 RelB antitoxin; Region: RelB; cl01171 585396000829 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585396000830 NlpC/P60 family; Region: NLPC_P60; pfam00877 585396000831 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 585396000832 HicB family; Region: HicB; pfam05534 585396000833 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 585396000834 FHIPEP family; Region: FHIPEP; pfam00771 585396000835 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 585396000836 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 585396000837 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 585396000838 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 585396000839 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 585396000840 flagellar motor switch protein FliN; Region: fliN; TIGR02480 585396000841 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 585396000842 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 585396000843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396000844 Walker A motif; other site 585396000845 ATP binding site [chemical binding]; other site 585396000846 Walker B motif; other site 585396000847 arginine finger; other site 585396000848 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585396000849 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 585396000850 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 585396000851 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 585396000852 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 585396000853 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 585396000854 MgtE intracellular N domain; Region: MgtE_N; smart00924 585396000855 FliG C-terminal domain; Region: FliG_C; pfam01706 585396000856 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 585396000857 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 585396000858 Flagellar assembly protein FliH; Region: FliH; pfam02108 585396000859 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 585396000860 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 585396000861 Walker A motif/ATP binding site; other site 585396000862 Walker B motif; other site 585396000863 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 585396000864 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585396000865 active site 585396000866 nucleotide binding site [chemical binding]; other site 585396000867 HIGH motif; other site 585396000868 KMSKS motif; other site 585396000869 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 585396000870 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 585396000871 active site 585396000872 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 585396000873 FlgN protein; Region: FlgN; pfam05130 585396000874 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 585396000875 SAF-like; Region: SAF_2; pfam13144 585396000876 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 585396000877 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 585396000878 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 585396000879 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 585396000880 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 585396000881 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585396000882 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619 585396000883 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 585396000884 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 585396000885 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 585396000886 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585396000887 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 585396000888 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585396000889 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 585396000890 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585396000891 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585396000892 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 585396000893 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585396000894 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 585396000895 Flagellar L-ring protein; Region: FlgH; pfam02107 585396000896 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 585396000897 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 585396000898 Rod binding protein; Region: Rod-binding; cl01626 585396000899 predicted lateral flagellar hook-filament junction protein (FlgK-like), N-terminal part 585396000900 predicted lateral flagellar hook-filament junction protein (FlgK-like), C-terminal part 585396000901 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 585396000902 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 585396000903 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 585396000904 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 585396000905 DNA binding site [nucleotide binding] 585396000906 flagellin; Reviewed; Region: PRK08869 585396000907 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 585396000908 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 585396000909 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 585396000910 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 585396000911 Flagellar protein FliS; Region: FliS; cl00654 585396000912 adenylate kinase; Region: PLN02674 585396000913 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 585396000914 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 585396000915 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 585396000916 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585396000917 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 585396000918 DNA binding residues [nucleotide binding] 585396000919 flagellar motor protein MotA; Provisional; Region: PRK12482 585396000920 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 585396000921 hypothetical protein; Validated; Region: PRK06778 585396000922 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 585396000923 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585396000924 ligand binding site [chemical binding]; other site 585396000925 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 585396000926 active site 585396000927 DNA polymerase IV; Validated; Region: PRK02406 585396000928 DNA binding site [nucleotide binding] 585396000929 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585396000930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396000931 Coenzyme A binding pocket [chemical binding]; other site 585396000932 hypothetical protein; Reviewed; Region: PRK09588 585396000933 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 585396000934 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 585396000935 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 585396000936 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 585396000937 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 585396000938 metal binding site [ion binding]; metal-binding site 585396000939 dimer interface [polypeptide binding]; other site 585396000940 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585396000941 active site 585396000942 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 585396000943 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 585396000944 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585396000945 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585396000946 trimer interface [polypeptide binding]; other site 585396000947 eyelet of channel; other site 585396000948 gamma-glutamyl kinase; Provisional; Region: PRK05429 585396000949 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 585396000950 nucleotide binding site [chemical binding]; other site 585396000951 homotetrameric interface [polypeptide binding]; other site 585396000952 putative phosphate binding site [ion binding]; other site 585396000953 putative allosteric binding site; other site 585396000954 PUA domain; Region: PUA; pfam01472 585396000955 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 585396000956 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 585396000957 putative catalytic cysteine [active] 585396000958 Integrative element ECO111_IE01 585396000959 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585396000960 putative transposase OrfB; Reviewed; Region: PHA02517 585396000961 HTH-like domain; Region: HTH_21; pfam13276 585396000962 Integrase core domain; Region: rve; pfam00665 585396000963 Integrase core domain; Region: rve_3; pfam13683 585396000964 Transposase; Region: HTH_Tnp_1; cl17663 585396000965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396000966 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585396000967 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585396000968 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585396000969 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585396000970 MPN+ (JAMM) motif; other site 585396000971 Zinc-binding site [ion binding]; other site 585396000972 Antirestriction protein; Region: Antirestrict; pfam03230 585396000973 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585396000974 putative transposase OrfB; Reviewed; Region: PHA02517 585396000975 HTH-like domain; Region: HTH_21; pfam13276 585396000976 Integrase core domain; Region: rve; pfam00665 585396000977 Integrase core domain; Region: rve_3; pfam13683 585396000978 Transposase; Region: HTH_Tnp_1; cl17663 585396000979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396000980 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 585396000981 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 585396000982 cofactor binding site; other site 585396000983 DNA binding site [nucleotide binding] 585396000984 substrate interaction site [chemical binding]; other site 585396000985 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 585396000986 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585396000987 active site 585396000988 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 585396000989 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 585396000990 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 585396000991 predicted invasin, N-terminal part 585396000992 predicted invasin, C-terminal part 585396000993 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 585396000994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396000995 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 585396000996 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585396000997 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585396000998 active site 585396000999 catalytic tetrad [active] 585396001000 Predicted membrane protein [Function unknown]; Region: COG3059 585396001001 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585396001002 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 585396001003 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 585396001004 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396001005 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585396001006 Cupin; Region: Cupin_6; pfam12852 585396001007 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585396001008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396001009 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 585396001010 Cysteine-rich domain; Region: CCG; pfam02754 585396001011 Cysteine-rich domain; Region: CCG; pfam02754 585396001012 iron-sulfur cluster-binding protein; Region: TIGR00273 585396001013 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 585396001014 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585396001015 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 585396001016 Uncharacterized conserved protein [Function unknown]; Region: COG1556 585396001017 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585396001018 choline dehydrogenase; Validated; Region: PRK02106 585396001019 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 585396001020 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 585396001021 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 585396001022 tetrameric interface [polypeptide binding]; other site 585396001023 NAD binding site [chemical binding]; other site 585396001024 catalytic residues [active] 585396001025 transcriptional regulator BetI; Validated; Region: PRK00767 585396001026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585396001027 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 585396001028 choline transport protein BetT; Provisional; Region: PRK09928 585396001029 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585396001030 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585396001031 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585396001032 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585396001033 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396001034 DNA binding residues [nucleotide binding] 585396001035 dimerization interface [polypeptide binding]; other site 585396001036 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396001037 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 585396001038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396001039 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585396001040 dimerization interface [polypeptide binding]; other site 585396001041 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 585396001042 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 585396001043 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 585396001044 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 585396001045 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 585396001046 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 585396001047 CoA binding domain; Region: CoA_binding; pfam02629 585396001048 CoA-ligase; Region: Ligase_CoA; pfam00549 585396001049 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 585396001050 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 585396001051 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585396001052 putative substrate binding site [chemical binding]; other site 585396001053 nucleotide binding site [chemical binding]; other site 585396001054 nucleotide binding site [chemical binding]; other site 585396001055 homodimer interface [polypeptide binding]; other site 585396001056 putative deaminase; Validated; Region: PRK06846 585396001057 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 585396001058 active site 585396001059 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 585396001060 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 585396001061 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 585396001062 ligand binding site [chemical binding]; other site 585396001063 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585396001064 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585396001065 Walker A/P-loop; other site 585396001066 ATP binding site [chemical binding]; other site 585396001067 Q-loop/lid; other site 585396001068 ABC transporter signature motif; other site 585396001069 Walker B; other site 585396001070 D-loop; other site 585396001071 H-loop/switch region; other site 585396001072 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585396001073 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585396001074 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585396001075 TM-ABC transporter signature motif; other site 585396001076 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585396001077 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585396001078 TM-ABC transporter signature motif; other site 585396001079 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 585396001080 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 585396001081 putative NAD(P) binding site [chemical binding]; other site 585396001082 putative substrate binding site [chemical binding]; other site 585396001083 catalytic Zn binding site [ion binding]; other site 585396001084 structural Zn binding site [ion binding]; other site 585396001085 dimer interface [polypeptide binding]; other site 585396001086 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 585396001087 hypothetical protein; Provisional; Region: PRK09929 585396001088 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 585396001089 Propionate catabolism activator; Region: PrpR_N; pfam06506 585396001090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396001091 Walker A motif; other site 585396001092 ATP binding site [chemical binding]; other site 585396001093 Walker B motif; other site 585396001094 arginine finger; other site 585396001095 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585396001096 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 585396001097 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 585396001098 tetramer interface [polypeptide binding]; other site 585396001099 active site 585396001100 Mg2+/Mn2+ binding site [ion binding]; other site 585396001101 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 585396001102 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 585396001103 dimer interface [polypeptide binding]; other site 585396001104 active site 585396001105 citrylCoA binding site [chemical binding]; other site 585396001106 oxalacetate/citrate binding site [chemical binding]; other site 585396001107 coenzyme A binding site [chemical binding]; other site 585396001108 catalytic triad [active] 585396001109 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 585396001110 2-methylcitrate dehydratase; Region: prpD; TIGR02330 585396001111 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 585396001112 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 585396001113 acyl-activating enzyme (AAE) consensus motif; other site 585396001114 putative AMP binding site [chemical binding]; other site 585396001115 putative active site [active] 585396001116 putative CoA binding site [chemical binding]; other site 585396001117 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 585396001118 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 585396001119 Na binding site [ion binding]; other site 585396001120 putative substrate binding site [chemical binding]; other site 585396001121 cytosine deaminase; Provisional; Region: PRK09230 585396001122 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 585396001123 active site 585396001124 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 585396001125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396001126 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 585396001127 dimerization interface [polypeptide binding]; other site 585396001128 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 585396001129 active site clefts [active] 585396001130 zinc binding site [ion binding]; other site 585396001131 dimer interface [polypeptide binding]; other site 585396001132 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 585396001133 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 585396001134 oligomer interface [polypeptide binding]; other site 585396001135 active site 585396001136 putative cyanate transporter; Provisional; Region: cynX; PRK09705 585396001137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396001138 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 585396001139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396001140 putative substrate translocation pore; other site 585396001141 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 585396001142 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 585396001143 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 585396001144 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 585396001145 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 585396001146 lac repressor; Reviewed; Region: lacI; PRK09526 585396001147 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396001148 DNA binding site [nucleotide binding] 585396001149 domain linker motif; other site 585396001150 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 585396001151 ligand binding site [chemical binding]; other site 585396001152 dimerization interface (open form) [polypeptide binding]; other site 585396001153 dimerization interface (closed form) [polypeptide binding]; other site 585396001154 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 585396001155 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585396001156 Bacterial transcriptional regulator; Region: IclR; pfam01614 585396001157 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 585396001158 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 585396001159 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 585396001160 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 585396001161 putative active site [active] 585396001162 Fe(II) binding site [ion binding]; other site 585396001163 putative dimer interface [polypeptide binding]; other site 585396001164 putative tetramer interface [polypeptide binding]; other site 585396001165 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 585396001166 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 585396001167 nucleophilic elbow; other site 585396001168 catalytic triad; other site 585396001169 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 585396001170 acetaldehyde dehydrogenase; Validated; Region: PRK08300 585396001171 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585396001172 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 585396001173 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 585396001174 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 585396001175 active site 585396001176 catalytic residues [active] 585396001177 metal binding site [ion binding]; metal-binding site 585396001178 DmpG-like communication domain; Region: DmpG_comm; pfam07836 585396001179 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 585396001180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396001181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396001182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 585396001183 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 585396001184 S-formylglutathione hydrolase; Region: PLN02442 585396001185 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 585396001186 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 585396001187 substrate binding site [chemical binding]; other site 585396001188 catalytic Zn binding site [ion binding]; other site 585396001189 NAD binding site [chemical binding]; other site 585396001190 structural Zn binding site [ion binding]; other site 585396001191 dimer interface [polypeptide binding]; other site 585396001192 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 585396001193 putative metal binding site [ion binding]; other site 585396001194 putative homodimer interface [polypeptide binding]; other site 585396001195 putative homotetramer interface [polypeptide binding]; other site 585396001196 putative homodimer-homodimer interface [polypeptide binding]; other site 585396001197 putative allosteric switch controlling residues; other site 585396001198 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 585396001199 putative trimer interface [polypeptide binding]; other site 585396001200 putative CoA binding site [chemical binding]; other site 585396001201 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 585396001202 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 585396001203 DXD motif; other site 585396001204 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 585396001205 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 585396001206 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396001207 substrate binding pocket [chemical binding]; other site 585396001208 membrane-bound complex binding site; other site 585396001209 hinge residues; other site 585396001210 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 585396001211 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 585396001212 Walker A/P-loop; other site 585396001213 ATP binding site [chemical binding]; other site 585396001214 Q-loop/lid; other site 585396001215 ABC transporter signature motif; other site 585396001216 Walker B; other site 585396001217 D-loop; other site 585396001218 H-loop/switch region; other site 585396001219 taurine transporter subunit TauC, membrane component of ABC superfamily, C-terminal part 585396001220 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 585396001221 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 585396001222 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 585396001223 dimer interface [polypeptide binding]; other site 585396001224 active site 585396001225 Schiff base residues; other site 585396001226 predicted flagellin structural protein, N-terminal part 585396001227 predicted flagellin structural protein, C-terminal part 585396001228 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 585396001229 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 585396001230 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585396001231 microcin B17 transporter; Reviewed; Region: PRK11098 585396001232 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 585396001233 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 585396001234 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 585396001235 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 585396001236 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 585396001237 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 585396001238 anti-RssB factor; Provisional; Region: PRK10244 585396001239 alkaline phosphatase; Provisional; Region: PRK10518 585396001240 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 585396001241 dimer interface [polypeptide binding]; other site 585396001242 active site 585396001243 hypothetical protein; Provisional; Region: PRK11505 585396001244 psiF repeat; Region: PsiF_repeat; pfam07769 585396001245 psiF repeat; Region: PsiF_repeat; pfam07769 585396001246 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 585396001247 MASE2 domain; Region: MASE2; pfam05230 585396001248 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396001249 metal binding site [ion binding]; metal-binding site 585396001250 active site 585396001251 I-site; other site 585396001252 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 585396001253 pyrroline-5-carboxylate reductase; Region: PLN02688 585396001254 hypothetical protein; Validated; Region: PRK00124 585396001255 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 585396001256 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 585396001257 ADP binding site [chemical binding]; other site 585396001258 magnesium binding site [ion binding]; other site 585396001259 putative shikimate binding site; other site 585396001260 hypothetical protein; Provisional; Region: PRK10380 585396001261 hypothetical protein; Provisional; Region: PRK10481 585396001262 hypothetical protein; Provisional; Region: PRK10579 585396001263 conserved predicted protein, C-terminal part 585396001264 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 585396001265 fructokinase; Reviewed; Region: PRK09557 585396001266 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585396001267 nucleotide binding site [chemical binding]; other site 585396001268 MFS transport protein AraJ; Provisional; Region: PRK10091 585396001269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396001270 putative substrate translocation pore; other site 585396001271 exonuclease subunit SbcC; Provisional; Region: PRK10246 585396001272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396001273 Walker A/P-loop; other site 585396001274 ATP binding site [chemical binding]; other site 585396001275 Q-loop/lid; other site 585396001276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396001277 ABC transporter signature motif; other site 585396001278 Walker B; other site 585396001279 D-loop; other site 585396001280 H-loop/switch region; other site 585396001281 exonuclease subunit SbcD; Provisional; Region: PRK10966 585396001282 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 585396001283 active site 585396001284 metal binding site [ion binding]; metal-binding site 585396001285 DNA binding site [nucleotide binding] 585396001286 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 585396001287 transcriptional regulator PhoB; Provisional; Region: PRK10161 585396001288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396001289 active site 585396001290 phosphorylation site [posttranslational modification] 585396001291 intermolecular recognition site; other site 585396001292 dimerization interface [polypeptide binding]; other site 585396001293 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396001294 DNA binding site [nucleotide binding] 585396001295 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 585396001296 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 585396001297 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585396001298 putative active site [active] 585396001299 heme pocket [chemical binding]; other site 585396001300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396001301 dimer interface [polypeptide binding]; other site 585396001302 phosphorylation site [posttranslational modification] 585396001303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396001304 ATP binding site [chemical binding]; other site 585396001305 Mg2+ binding site [ion binding]; other site 585396001306 G-X-G motif; other site 585396001307 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 585396001308 putative proline-specific permease; Provisional; Region: proY; PRK10580 585396001309 Spore germination protein; Region: Spore_permease; cl17796 585396001310 maltodextrin glucosidase, N-terminal part 585396001311 maltodextrin glucosidase, C-terminal part 585396001312 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 585396001313 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 585396001314 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 585396001315 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 585396001316 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 585396001317 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 585396001318 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 585396001319 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 585396001320 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 585396001321 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 585396001322 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 585396001323 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 585396001324 Protein export membrane protein; Region: SecD_SecF; pfam02355 585396001325 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585396001326 active site 585396001327 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 585396001328 hypothetical protein; Provisional; Region: PRK11530 585396001329 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 585396001330 ATP cone domain; Region: ATP-cone; pfam03477 585396001331 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 585396001332 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 585396001333 catalytic motif [active] 585396001334 Zn binding site [ion binding]; other site 585396001335 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 585396001336 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 585396001337 homopentamer interface [polypeptide binding]; other site 585396001338 active site 585396001339 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 585396001340 putative RNA binding site [nucleotide binding]; other site 585396001341 thiamine monophosphate kinase; Provisional; Region: PRK05731 585396001342 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 585396001343 ATP binding site [chemical binding]; other site 585396001344 dimerization interface [polypeptide binding]; other site 585396001345 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 585396001346 tetramer interfaces [polypeptide binding]; other site 585396001347 binuclear metal-binding site [ion binding]; other site 585396001348 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585396001349 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585396001350 active site 585396001351 catalytic tetrad [active] 585396001352 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 585396001353 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 585396001354 TPP-binding site; other site 585396001355 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585396001356 PYR/PP interface [polypeptide binding]; other site 585396001357 dimer interface [polypeptide binding]; other site 585396001358 TPP binding site [chemical binding]; other site 585396001359 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585396001360 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 585396001361 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 585396001362 substrate binding pocket [chemical binding]; other site 585396001363 chain length determination region; other site 585396001364 substrate-Mg2+ binding site; other site 585396001365 catalytic residues [active] 585396001366 aspartate-rich region 1; other site 585396001367 active site lid residues [active] 585396001368 aspartate-rich region 2; other site 585396001369 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 585396001370 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 585396001371 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 585396001372 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 585396001373 Ligand Binding Site [chemical binding]; other site 585396001374 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585396001375 active site residue [active] 585396001376 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 585396001377 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 585396001378 conserved cys residue [active] 585396001379 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 585396001380 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 585396001381 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 585396001382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 585396001383 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 585396001384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396001385 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585396001386 putative substrate translocation pore; other site 585396001387 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585396001388 Sel1 repeat; Region: Sel1; pfam08238 585396001389 Sel1-like repeats; Region: SEL1; smart00671 585396001390 Sel1-like repeats; Region: SEL1; smart00671 585396001391 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 585396001392 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 585396001393 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 585396001394 UbiA prenyltransferase family; Region: UbiA; pfam01040 585396001395 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 585396001396 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 585396001397 Subunit I/III interface [polypeptide binding]; other site 585396001398 Subunit III/IV interface [polypeptide binding]; other site 585396001399 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 585396001400 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 585396001401 D-pathway; other site 585396001402 Putative ubiquinol binding site [chemical binding]; other site 585396001403 Low-spin heme (heme b) binding site [chemical binding]; other site 585396001404 Putative water exit pathway; other site 585396001405 Binuclear center (heme o3/CuB) [ion binding]; other site 585396001406 K-pathway; other site 585396001407 Putative proton exit pathway; other site 585396001408 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 585396001409 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 585396001410 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 585396001411 muropeptide transporter; Reviewed; Region: ampG; PRK11902 585396001412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396001413 putative substrate translocation pore; other site 585396001414 hypothetical protein; Provisional; Region: PRK11627 585396001415 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 585396001416 transcriptional regulator BolA; Provisional; Region: PRK11628 585396001417 trigger factor; Provisional; Region: tig; PRK01490 585396001418 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585396001419 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 585396001420 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 585396001421 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 585396001422 oligomer interface [polypeptide binding]; other site 585396001423 active site residues [active] 585396001424 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 585396001425 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 585396001426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396001427 Walker A motif; other site 585396001428 ATP binding site [chemical binding]; other site 585396001429 Walker B motif; other site 585396001430 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585396001431 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 585396001432 Found in ATP-dependent protease La (LON); Region: LON; smart00464 585396001433 Found in ATP-dependent protease La (LON); Region: LON; smart00464 585396001434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396001435 Walker A motif; other site 585396001436 ATP binding site [chemical binding]; other site 585396001437 Walker B motif; other site 585396001438 arginine finger; other site 585396001439 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 585396001440 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585396001441 IHF dimer interface [polypeptide binding]; other site 585396001442 IHF - DNA interface [nucleotide binding]; other site 585396001443 periplasmic folding chaperone; Provisional; Region: PRK10788 585396001444 SurA N-terminal domain; Region: SurA_N_3; cl07813 585396001445 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 585396001446 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 585396001447 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 585396001448 active site 585396001449 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 585396001450 Ligand Binding Site [chemical binding]; other site 585396001451 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 585396001452 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 585396001453 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 585396001454 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 585396001455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396001456 active site 585396001457 motif I; other site 585396001458 motif II; other site 585396001459 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 585396001460 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585396001461 putative DNA binding site [nucleotide binding]; other site 585396001462 putative Zn2+ binding site [ion binding]; other site 585396001463 AsnC family; Region: AsnC_trans_reg; pfam01037 585396001464 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585396001465 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 585396001466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396001467 Walker A/P-loop; other site 585396001468 ATP binding site [chemical binding]; other site 585396001469 Q-loop/lid; other site 585396001470 ABC transporter signature motif; other site 585396001471 Walker B; other site 585396001472 D-loop; other site 585396001473 H-loop/switch region; other site 585396001474 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 585396001475 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585396001476 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 585396001477 Walker A/P-loop; other site 585396001478 ATP binding site [chemical binding]; other site 585396001479 Q-loop/lid; other site 585396001480 ABC transporter signature motif; other site 585396001481 Walker B; other site 585396001482 D-loop; other site 585396001483 H-loop/switch region; other site 585396001484 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 585396001485 Nitrogen regulatory protein P-II; Region: P-II; smart00938 585396001486 ammonium transporter; Provisional; Region: PRK10666 585396001487 acyl-CoA thioesterase II; Provisional; Region: PRK10526 585396001488 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 585396001489 active site 585396001490 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 585396001491 catalytic triad [active] 585396001492 dimer interface [polypeptide binding]; other site 585396001493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 585396001494 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 585396001495 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585396001496 DNA binding site [nucleotide binding] 585396001497 active site 585396001498 Uncharacterized conserved protein [Function unknown]; Region: COG5507 585396001499 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 585396001500 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585396001501 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396001502 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 585396001503 maltose O-acetyltransferase; Provisional; Region: PRK10092 585396001504 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 585396001505 active site 585396001506 substrate binding site [chemical binding]; other site 585396001507 trimer interface [polypeptide binding]; other site 585396001508 CoA binding site [chemical binding]; other site 585396001509 gene expression modulator; Provisional; Region: PRK10945 585396001510 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 585396001511 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 585396001512 Protein export membrane protein; Region: SecD_SecF; cl14618 585396001513 Protein export membrane protein; Region: SecD_SecF; cl14618 585396001514 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 585396001515 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396001516 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396001517 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 585396001518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585396001519 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 585396001520 hypothetical protein; Provisional; Region: PRK11281 585396001521 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 585396001522 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 585396001523 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585396001524 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396001525 Transposase; Region: HTH_Tnp_1; cl17663 585396001526 predicted transposase OrfB protein of insertion sequence IS602, C-terminal fragment 585396001527 putative transposase of IS621, N-terminal fragment 585396001528 hypothetical protein; Provisional; Region: PRK11038 585396001529 primosomal replication protein N''; Provisional; Region: PRK10093 585396001530 hypothetical protein; Provisional; Region: PRK10527 585396001531 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585396001532 active site 585396001533 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 585396001534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396001535 Walker A motif; other site 585396001536 ATP binding site [chemical binding]; other site 585396001537 Walker B motif; other site 585396001538 DNA polymerase III subunit delta'; Validated; Region: PRK08485 585396001539 arginine finger; other site 585396001540 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 585396001541 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 585396001542 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 585396001543 hypothetical protein; Validated; Region: PRK00153 585396001544 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 585396001545 RecR protein; Region: RecR; pfam02132 585396001546 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 585396001547 putative active site [active] 585396001548 putative metal-binding site [ion binding]; other site 585396001549 tetramer interface [polypeptide binding]; other site 585396001550 heat shock protein 90; Provisional; Region: PRK05218 585396001551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396001552 ATP binding site [chemical binding]; other site 585396001553 Mg2+ binding site [ion binding]; other site 585396001554 G-X-G motif; other site 585396001555 adenylate kinase; Reviewed; Region: adk; PRK00279 585396001556 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 585396001557 AMP-binding site [chemical binding]; other site 585396001558 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 585396001559 ferrochelatase; Region: hemH; TIGR00109 585396001560 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 585396001561 C-terminal domain interface [polypeptide binding]; other site 585396001562 active site 585396001563 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 585396001564 active site 585396001565 N-terminal domain interface [polypeptide binding]; other site 585396001566 acetyl esterase; Provisional; Region: PRK10162 585396001567 inosine/guanosine kinase; Provisional; Region: PRK15074 585396001568 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585396001569 putative cation:proton antiport protein; Provisional; Region: PRK10669 585396001570 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 585396001571 TrkA-N domain; Region: TrkA_N; pfam02254 585396001572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396001573 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585396001574 putative substrate translocation pore; other site 585396001575 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 585396001576 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 585396001577 active site 585396001578 metal binding site [ion binding]; metal-binding site 585396001579 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585396001580 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 585396001581 putative deacylase active site [active] 585396001582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 585396001583 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 585396001584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396001585 sequence-specific DNA binding site [nucleotide binding]; other site 585396001586 salt bridge; other site 585396001587 copper exporting ATPase; Provisional; Region: copA; PRK10671 585396001588 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585396001589 metal-binding site [ion binding] 585396001590 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585396001591 metal-binding site [ion binding] 585396001592 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585396001593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396001594 motif II; other site 585396001595 glutaminase; Reviewed; Region: PRK12356 585396001596 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 585396001597 amino acid transporter; Region: 2A0306; TIGR00909 585396001598 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 585396001599 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 585396001600 DNA binding residues [nucleotide binding] 585396001601 dimer interface [polypeptide binding]; other site 585396001602 copper binding site [ion binding]; other site 585396001603 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 585396001604 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 585396001605 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 585396001606 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 585396001607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396001608 Walker A/P-loop; other site 585396001609 ATP binding site [chemical binding]; other site 585396001610 Q-loop/lid; other site 585396001611 ABC transporter signature motif; other site 585396001612 Walker B; other site 585396001613 D-loop; other site 585396001614 H-loop/switch region; other site 585396001615 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 585396001616 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 585396001617 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 585396001618 oxidoreductase; Provisional; Region: PRK08017 585396001619 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 585396001620 NADP binding site [chemical binding]; other site 585396001621 active site 585396001622 steroid binding site; other site 585396001623 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 585396001624 active site 585396001625 catalytic triad [active] 585396001626 oxyanion hole [active] 585396001627 switch loop; other site 585396001628 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 585396001629 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585396001630 Walker A/P-loop; other site 585396001631 ATP binding site [chemical binding]; other site 585396001632 Q-loop/lid; other site 585396001633 ABC transporter signature motif; other site 585396001634 Walker B; other site 585396001635 D-loop; other site 585396001636 H-loop/switch region; other site 585396001637 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 585396001638 FtsX-like permease family; Region: FtsX; pfam02687 585396001639 FtsX-like permease family; Region: FtsX; pfam02687 585396001640 RhsD core protein with extension, C-terminal part truncated 585396001641 hypothetical protein; Provisional; Region: PRK14710 585396001642 conserved predicted protein, N-terminal fragment 585396001643 Winged helix-turn helix; Region: HTH_29; pfam13551 585396001644 Helix-turn-helix domain; Region: HTH_28; pfam13518 585396001645 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 585396001646 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 585396001647 active site residue [active] 585396001648 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 585396001649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396001650 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585396001651 dimerization interface [polypeptide binding]; other site 585396001652 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 585396001653 ureidoglycolate hydrolase; Provisional; Region: PRK03606 585396001654 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 585396001655 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585396001656 Bacterial transcriptional regulator; Region: IclR; pfam01614 585396001657 glyoxylate carboligase; Provisional; Region: PRK11269 585396001658 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585396001659 PYR/PP interface [polypeptide binding]; other site 585396001660 dimer interface [polypeptide binding]; other site 585396001661 TPP binding site [chemical binding]; other site 585396001662 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585396001663 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 585396001664 TPP-binding site [chemical binding]; other site 585396001665 hydroxypyruvate isomerase; Provisional; Region: PRK09997 585396001666 tartronate semialdehyde reductase; Provisional; Region: PRK15059 585396001667 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585396001668 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 585396001669 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 585396001670 Na binding site [ion binding]; other site 585396001671 substrate binding site [chemical binding]; other site 585396001672 allantoinase; Provisional; Region: PRK08044 585396001673 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 585396001674 active site 585396001675 putative uracil/xanthine transporter; Provisional; Region: PRK11412 585396001676 glycerate kinase II; Provisional; Region: PRK09932 585396001677 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 585396001678 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 585396001679 Cupin domain; Region: Cupin_2; cl17218 585396001680 allantoate amidohydrolase; Region: AllC; TIGR03176 585396001681 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 585396001682 active site 585396001683 metal binding site [ion binding]; metal-binding site 585396001684 dimer interface [polypeptide binding]; other site 585396001685 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 585396001686 membrane protein FdrA; Validated; Region: PRK06091 585396001687 CoA binding domain; Region: CoA_binding; pfam02629 585396001688 CoA-ligase; Region: Ligase_CoA; pfam00549 585396001689 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 585396001690 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 585396001691 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 585396001692 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585396001693 putative substrate binding site [chemical binding]; other site 585396001694 nucleotide binding site [chemical binding]; other site 585396001695 nucleotide binding site [chemical binding]; other site 585396001696 homodimer interface [polypeptide binding]; other site 585396001697 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 585396001698 ATP-grasp domain; Region: ATP-grasp; pfam02222 585396001699 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 585396001700 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 585396001701 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585396001702 putative active site [active] 585396001703 putative metal binding site [ion binding]; other site 585396001704 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 585396001705 substrate binding site [chemical binding]; other site 585396001706 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 585396001707 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 585396001708 active site 585396001709 HIGH motif; other site 585396001710 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 585396001711 KMSKS motif; other site 585396001712 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 585396001713 tRNA binding surface [nucleotide binding]; other site 585396001714 anticodon binding site; other site 585396001715 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 585396001716 ribosome-associated protein; Provisional; Region: PRK11507 585396001717 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 585396001718 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 585396001719 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 585396001720 homodimer interface [polypeptide binding]; other site 585396001721 NADP binding site [chemical binding]; other site 585396001722 substrate binding site [chemical binding]; other site 585396001723 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 585396001724 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 585396001725 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585396001726 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585396001727 outer membrane usher protein FimD; Provisional; Region: PRK15198 585396001728 PapC N-terminal domain; Region: PapC_N; pfam13954 585396001729 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585396001730 PapC C-terminal domain; Region: PapC_C; pfam13953 585396001731 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 585396001732 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 585396001733 transcriptional regulator FimZ; Provisional; Region: PRK09935 585396001734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396001735 active site 585396001736 phosphorylation site [posttranslational modification] 585396001737 intermolecular recognition site; other site 585396001738 dimerization interface [polypeptide binding]; other site 585396001739 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396001740 DNA binding residues [nucleotide binding] 585396001741 dimerization interface [polypeptide binding]; other site 585396001742 Prophage ECO111_P01, lambda-like phage 585396001743 Prophage ECO111_P01; predicted minor capsid protein, C-terminal fragment 585396001744 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585396001745 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585396001746 DNA packaging protein FI; Region: Packaging_FI; pfam14000 585396001747 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 585396001748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396001749 Transposase; Region: HTH_Tnp_1; cl17663 585396001750 Integrase core domain; Region: rve; pfam00665 585396001751 DDE domain; Region: DDE_Tnp_IS240; pfam13610 585396001752 Integrase core domain; Region: rve_3; pfam13683 585396001753 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585396001754 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585396001755 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585396001756 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585396001757 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 585396001758 Minor tail protein T; Region: Phage_tail_T; pfam06223 585396001759 Phage-related minor tail protein [Function unknown]; Region: COG5281 585396001760 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585396001761 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585396001762 Transposase; Region: HTH_Tnp_1; cl17663 585396001763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396001764 putative transposase OrfB; Reviewed; Region: PHA02517 585396001765 HTH-like domain; Region: HTH_21; pfam13276 585396001766 Integrase core domain; Region: rve; pfam00665 585396001767 Integrase core domain; Region: rve_3; pfam13683 585396001768 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585396001769 Methyltransferase domain; Region: Methyltransf_12; pfam08242 585396001770 S-adenosylmethionine binding site [chemical binding]; other site 585396001771 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585396001772 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 585396001773 TAP-like protein; Region: Abhydrolase_4; pfam08386 585396001774 outer membrane protease; Reviewed; Region: PRK10993 585396001775 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585396001776 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396001777 hypothetical protein; Provisional; Region: PRK09936 585396001778 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 585396001779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585396001780 TPR motif; other site 585396001781 binding surface 585396001782 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 585396001783 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 585396001784 active site 585396001785 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 585396001786 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 585396001787 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 585396001788 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585396001789 Transposase [DNA replication, recombination, and repair]; Region: COG5433 585396001790 Transposase [DNA replication, recombination, and repair]; Region: COG5433 585396001791 Rhs core protein, central part 585396001792 RhsK core protein with extension, C-terminal degraded 585396001793 Uncharacterized conserved protein [Function unknown]; Region: COG5435 585396001794 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 585396001795 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585396001796 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585396001797 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585396001798 sensor kinase CusS; Provisional; Region: PRK09835 585396001799 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585396001800 dimerization interface [polypeptide binding]; other site 585396001801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396001802 dimer interface [polypeptide binding]; other site 585396001803 phosphorylation site [posttranslational modification] 585396001804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396001805 ATP binding site [chemical binding]; other site 585396001806 Mg2+ binding site [ion binding]; other site 585396001807 G-X-G motif; other site 585396001808 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 585396001809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396001810 active site 585396001811 phosphorylation site [posttranslational modification] 585396001812 intermolecular recognition site; other site 585396001813 dimerization interface [polypeptide binding]; other site 585396001814 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396001815 DNA binding site [nucleotide binding] 585396001816 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 585396001817 periplasmic copper-binding protein; Provisional; Region: PRK09838 585396001818 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 585396001819 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396001820 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 585396001821 phenylalanine transporter; Provisional; Region: PRK10249 585396001822 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 585396001823 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585396001824 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 585396001825 dimer interface [polypeptide binding]; other site 585396001826 FMN binding site [chemical binding]; other site 585396001827 hypothetical protein; Provisional; Region: PRK10250 585396001828 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 585396001829 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 585396001830 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 585396001831 Hok/gef family; Region: HOK_GEF; pfam01848 585396001832 Hok/gef family; Region: HOK_GEF; pfam01848 585396001833 Hok/gef family; Region: HOK_GEF; pfam01848 585396001834 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 585396001835 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 585396001836 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 585396001837 outer membrane receptor FepA; Provisional; Region: PRK13524 585396001838 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585396001839 N-terminal plug; other site 585396001840 ligand-binding site [chemical binding]; other site 585396001841 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 585396001842 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 585396001843 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585396001844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 585396001845 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 585396001846 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 585396001847 acyl-activating enzyme (AAE) consensus motif; other site 585396001848 AMP binding site [chemical binding]; other site 585396001849 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585396001850 LPS O-antigen length regulator; Provisional; Region: PRK10381 585396001851 Chain length determinant protein; Region: Wzz; pfam02706 585396001852 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585396001853 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 585396001854 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585396001855 Walker A/P-loop; other site 585396001856 ATP binding site [chemical binding]; other site 585396001857 Q-loop/lid; other site 585396001858 ABC transporter signature motif; other site 585396001859 Walker B; other site 585396001860 D-loop; other site 585396001861 H-loop/switch region; other site 585396001862 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 585396001863 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585396001864 ABC-ATPase subunit interface; other site 585396001865 dimer interface [polypeptide binding]; other site 585396001866 putative PBP binding regions; other site 585396001867 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585396001868 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585396001869 ABC-ATPase subunit interface; other site 585396001870 dimer interface [polypeptide binding]; other site 585396001871 putative PBP binding regions; other site 585396001872 enterobactin exporter EntS; Provisional; Region: PRK10489 585396001873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396001874 putative substrate translocation pore; other site 585396001875 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 585396001876 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 585396001877 siderophore binding site; other site 585396001878 isochorismate synthase EntC; Provisional; Region: PRK15016 585396001879 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 585396001880 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 585396001881 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 585396001882 acyl-activating enzyme (AAE) consensus motif; other site 585396001883 active site 585396001884 AMP binding site [chemical binding]; other site 585396001885 substrate binding site [chemical binding]; other site 585396001886 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 585396001887 hydrophobic substrate binding pocket; other site 585396001888 Isochorismatase family; Region: Isochorismatase; pfam00857 585396001889 active site 585396001890 conserved cis-peptide bond; other site 585396001891 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 585396001892 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 585396001893 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 585396001894 putative NAD(P) binding site [chemical binding]; other site 585396001895 active site 585396001896 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585396001897 CoenzymeA binding site [chemical binding]; other site 585396001898 subunit interaction site [polypeptide binding]; other site 585396001899 PHB binding site; other site 585396001900 carbon starvation protein A; Provisional; Region: PRK15015 585396001901 Carbon starvation protein CstA; Region: CstA; pfam02554 585396001902 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 585396001903 Uncharacterized small protein [Function unknown]; Region: COG2879 585396001904 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 585396001905 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 585396001906 putative active site [active] 585396001907 metal binding site [ion binding]; metal-binding site 585396001908 methionine aminotransferase; Validated; Region: PRK09082 585396001909 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585396001910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396001911 homodimer interface [polypeptide binding]; other site 585396001912 catalytic residue [active] 585396001913 conserved predicted protein, C-terminal part 585396001914 conserved predicted protein, N-terminal part 585396001915 conserved predicted protein, C-terminal part 585396001916 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 585396001917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396001918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585396001919 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 585396001920 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 585396001921 dimerization domain [polypeptide binding]; other site 585396001922 dimer interface [polypeptide binding]; other site 585396001923 catalytic residues [active] 585396001924 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 585396001925 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 585396001926 dimer interface [polypeptide binding]; other site 585396001927 decamer (pentamer of dimers) interface [polypeptide binding]; other site 585396001928 catalytic triad [active] 585396001929 peroxidatic and resolving cysteines [active] 585396001930 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 585396001931 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 585396001932 catalytic residue [active] 585396001933 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 585396001934 catalytic residues [active] 585396001935 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585396001936 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396001937 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585396001938 Ligand Binding Site [chemical binding]; other site 585396001939 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 585396001940 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585396001941 NAD binding site [chemical binding]; other site 585396001942 catalytic Zn binding site [ion binding]; other site 585396001943 structural Zn binding site [ion binding]; other site 585396001944 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 585396001945 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585396001946 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 585396001947 B1 nucleotide binding pocket [chemical binding]; other site 585396001948 B2 nucleotide binding pocket [chemical binding]; other site 585396001949 CAS motifs; other site 585396001950 active site 585396001951 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585396001952 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585396001953 transmembrane helices; other site 585396001954 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 585396001955 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 585396001956 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 585396001957 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 585396001958 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 585396001959 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 585396001960 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 585396001961 putative active site [active] 585396001962 (T/H)XGH motif; other site 585396001963 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 585396001964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585396001965 putative active site [active] 585396001966 heme pocket [chemical binding]; other site 585396001967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396001968 ATP binding site [chemical binding]; other site 585396001969 Mg2+ binding site [ion binding]; other site 585396001970 G-X-G motif; other site 585396001971 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 585396001972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396001973 active site 585396001974 phosphorylation site [posttranslational modification] 585396001975 intermolecular recognition site; other site 585396001976 dimerization interface [polypeptide binding]; other site 585396001977 Transcriptional regulator; Region: CitT; pfam12431 585396001978 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 585396001979 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 585396001980 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 585396001981 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585396001982 DNA-binding site [nucleotide binding]; DNA binding site 585396001983 RNA-binding motif; other site 585396001984 chromosome condensation membrane protein; Provisional; Region: PRK14196 585396001985 Predicted amidohydrolase [General function prediction only]; Region: COG0388 585396001986 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 585396001987 putative active site [active] 585396001988 catalytic triad [active] 585396001989 putative dimer interface [polypeptide binding]; other site 585396001990 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 585396001991 lipoyl synthase; Provisional; Region: PRK05481 585396001992 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396001993 FeS/SAM binding site; other site 585396001994 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 585396001995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396001996 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 585396001997 substrate binding pocket [chemical binding]; other site 585396001998 dimerization interface [polypeptide binding]; other site 585396001999 lipoate-protein ligase B; Provisional; Region: PRK14342 585396002000 hypothetical protein; Provisional; Region: PRK04998 585396002001 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 585396002002 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585396002003 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 585396002004 rare lipoprotein A; Provisional; Region: PRK10672 585396002005 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 585396002006 Sporulation related domain; Region: SPOR; pfam05036 585396002007 cell wall shape-determining protein; Provisional; Region: PRK10794 585396002008 penicillin-binding protein 2; Provisional; Region: PRK10795 585396002009 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 585396002010 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 585396002011 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 585396002012 ribosome-associated protein; Provisional; Region: PRK11538 585396002013 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585396002014 catalytic core [active] 585396002015 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 585396002016 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 585396002017 active site 585396002018 (T/H)XGH motif; other site 585396002019 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 585396002020 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 585396002021 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 585396002022 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 585396002023 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 585396002024 HIGH motif; other site 585396002025 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 585396002026 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585396002027 active site 585396002028 KMSKS motif; other site 585396002029 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 585396002030 tRNA binding surface [nucleotide binding]; other site 585396002031 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 585396002032 hypothetical protein; Provisional; Region: PRK11032 585396002033 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 585396002034 Sel1-like repeats; Region: SEL1; smart00671 585396002035 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585396002036 Sel1-like repeats; Region: SEL1; smart00671 585396002037 Sel1-like repeats; Region: SEL1; smart00671 585396002038 Sel1-like repeats; Region: SEL1; smart00671 585396002039 Sel1-like repeats; Region: SEL1; smart00671 585396002040 Sel1-like repeats; Region: SEL1; smart00671 585396002041 Sel1-like repeats; Region: SEL1; smart00671 585396002042 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 585396002043 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 585396002044 HSP70 interaction site [polypeptide binding]; other site 585396002045 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585396002046 Sel1-like repeats; Region: SEL1; smart00671 585396002047 Sel1-like repeats; Region: SEL1; smart00671 585396002048 Sel1-like repeats; Region: SEL1; smart00671 585396002049 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 585396002050 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 585396002051 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 585396002052 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 585396002053 nucleotide binding site [chemical binding]; other site 585396002054 putative NEF/HSP70 interaction site [polypeptide binding]; other site 585396002055 SBD interface [polypeptide binding]; other site 585396002056 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585396002057 active site 585396002058 tetramer interface [polypeptide binding]; other site 585396002059 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 585396002060 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585396002061 Walker A/P-loop; other site 585396002062 ATP binding site [chemical binding]; other site 585396002063 Q-loop/lid; other site 585396002064 ABC transporter signature motif; other site 585396002065 Walker B; other site 585396002066 D-loop; other site 585396002067 H-loop/switch region; other site 585396002068 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585396002069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396002070 dimer interface [polypeptide binding]; other site 585396002071 conserved gate region; other site 585396002072 putative PBP binding loops; other site 585396002073 ABC-ATPase subunit interface; other site 585396002074 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585396002075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396002076 dimer interface [polypeptide binding]; other site 585396002077 conserved gate region; other site 585396002078 putative PBP binding loops; other site 585396002079 ABC-ATPase subunit interface; other site 585396002080 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 585396002081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396002082 substrate binding pocket [chemical binding]; other site 585396002083 membrane-bound complex binding site; other site 585396002084 hinge residues; other site 585396002085 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 585396002086 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 585396002087 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 585396002088 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 585396002089 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 585396002090 putative active site [active] 585396002091 catalytic triad [active] 585396002092 putative dimer interface [polypeptide binding]; other site 585396002093 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 585396002094 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585396002095 Transporter associated domain; Region: CorC_HlyC; smart01091 585396002096 metal-binding heat shock protein; Provisional; Region: PRK00016 585396002097 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 585396002098 PhoH-like protein; Region: PhoH; pfam02562 585396002099 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 585396002100 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 585396002101 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396002102 FeS/SAM binding site; other site 585396002103 TRAM domain; Region: TRAM; pfam01938 585396002104 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 585396002105 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 585396002106 asparagine synthetase B; Provisional; Region: asnB; PRK09431 585396002107 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 585396002108 active site 585396002109 dimer interface [polypeptide binding]; other site 585396002110 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 585396002111 Ligand Binding Site [chemical binding]; other site 585396002112 Molecular Tunnel; other site 585396002113 UMP phosphatase; Provisional; Region: PRK10444 585396002114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396002115 active site 585396002116 motif I; other site 585396002117 motif II; other site 585396002118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396002119 MarR family; Region: MarR; pfam01047 585396002120 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585396002121 ROK family; Region: ROK; pfam00480 585396002122 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 585396002123 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 585396002124 active site 585396002125 dimer interface [polypeptide binding]; other site 585396002126 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585396002127 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585396002128 active site 585396002129 trimer interface [polypeptide binding]; other site 585396002130 allosteric site; other site 585396002131 active site lid [active] 585396002132 hexamer (dimer of trimers) interface [polypeptide binding]; other site 585396002133 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 585396002134 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585396002135 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585396002136 active site turn [active] 585396002137 phosphorylation site [posttranslational modification] 585396002138 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585396002139 HPr interaction site; other site 585396002140 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585396002141 active site 585396002142 phosphorylation site [posttranslational modification] 585396002143 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 585396002144 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585396002145 active site 585396002146 HIGH motif; other site 585396002147 nucleotide binding site [chemical binding]; other site 585396002148 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 585396002149 KMSKS motif; other site 585396002150 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 585396002151 outer membrane porin, OprD family; Region: OprD; pfam03573 585396002152 YbfN-like lipoprotein; Region: YbfN; pfam13982 585396002153 ferric uptake regulator; Provisional; Region: fur; PRK09462 585396002154 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 585396002155 metal binding site 2 [ion binding]; metal-binding site 585396002156 putative DNA binding helix; other site 585396002157 metal binding site 1 [ion binding]; metal-binding site 585396002158 dimer interface [polypeptide binding]; other site 585396002159 structural Zn2+ binding site [ion binding]; other site 585396002160 ryhB-regulated fur leader peptide; Provisional; Region: PRK14761 585396002161 flavodoxin FldA; Validated; Region: PRK09267 585396002162 LexA regulated protein; Provisional; Region: PRK11675 585396002163 acyl-CoA esterase; Provisional; Region: PRK10673 585396002164 PGAP1-like protein; Region: PGAP1; pfam07819 585396002165 replication initiation regulator SeqA; Provisional; Region: PRK11187 585396002166 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 585396002167 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 585396002168 active site 585396002169 substrate binding site [chemical binding]; other site 585396002170 metal binding site [ion binding]; metal-binding site 585396002171 putrescine/proton symporter PotE: putrescine/ornithine antiporter, C-terminal part 585396002172 putrescine/proton symporter PotE: putrescine/ornithine antiporter, N-terminal part 585396002173 ornithine decarboxylase; Provisional; Region: PRK13578 585396002174 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585396002175 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585396002176 homodimer interface [polypeptide binding]; other site 585396002177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396002178 catalytic residue [active] 585396002179 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585396002180 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 585396002181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396002182 active site 585396002183 phosphorylation site [posttranslational modification] 585396002184 intermolecular recognition site; other site 585396002185 dimerization interface [polypeptide binding]; other site 585396002186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396002187 DNA binding site [nucleotide binding] 585396002188 sensor protein KdpD; Provisional; Region: PRK10490 585396002189 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 585396002190 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 585396002191 Ligand Binding Site [chemical binding]; other site 585396002192 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 585396002193 GAF domain; Region: GAF_3; pfam13492 585396002194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396002195 dimer interface [polypeptide binding]; other site 585396002196 phosphorylation site [posttranslational modification] 585396002197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396002198 ATP binding site [chemical binding]; other site 585396002199 Mg2+ binding site [ion binding]; other site 585396002200 G-X-G motif; other site 585396002201 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 585396002202 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 585396002203 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585396002204 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 585396002205 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 585396002206 PAAR motif; Region: PAAR_motif; cl15808 585396002207 RHS Repeat; Region: RHS_repeat; pfam05593 585396002208 RHS Repeat; Region: RHS_repeat; pfam05593 585396002209 RHS Repeat; Region: RHS_repeat; pfam05593 585396002210 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585396002211 RHS Repeat; Region: RHS_repeat; pfam05593 585396002212 RHS Repeat; Region: RHS_repeat; pfam05593 585396002213 RHS protein; Region: RHS; pfam03527 585396002214 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585396002215 Rhs core protein with extension, C-terminal fragment 585396002216 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 585396002217 RhsC, IS677, putative H repeat-associated protein, central part 585396002218 hypothetical protein; Provisional; Region: PRK10167 585396002219 Uncharacterized conserved protein [Function unknown]; Region: COG3272 585396002220 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 585396002221 DNA photolyase; Region: DNA_photolyase; pfam00875 585396002222 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 585396002223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396002224 putative substrate translocation pore; other site 585396002225 POT family; Region: PTR2; pfam00854 585396002226 Uncharacterized conserved protein [Function unknown]; Region: COG0327 585396002227 metal-binding protein; Provisional; Region: PRK10799 585396002228 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 585396002229 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 585396002230 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 585396002231 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 585396002232 putative active site [active] 585396002233 endonuclease VIII; Provisional; Region: PRK10445 585396002234 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 585396002235 DNA binding site [nucleotide binding] 585396002236 catalytic residue [active] 585396002237 putative catalytic residues [active] 585396002238 H2TH interface [polypeptide binding]; other site 585396002239 intercalation triad [nucleotide binding]; other site 585396002240 substrate specificity determining residue; other site 585396002241 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 585396002242 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585396002243 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 585396002244 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 585396002245 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 585396002246 Fimbrial protein; Region: Fimbrial; pfam00419 585396002247 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585396002248 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585396002249 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585396002250 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585396002251 PapC N-terminal domain; Region: PapC_N; pfam13954 585396002252 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585396002253 PapC C-terminal domain; Region: PapC_C; pfam13953 585396002254 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585396002255 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 585396002256 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 585396002257 dimer interface [polypeptide binding]; other site 585396002258 active site 585396002259 citrylCoA binding site [chemical binding]; other site 585396002260 NADH binding [chemical binding]; other site 585396002261 cationic pore residues; other site 585396002262 oxalacetate/citrate binding site [chemical binding]; other site 585396002263 coenzyme A binding site [chemical binding]; other site 585396002264 catalytic triad [active] 585396002265 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 585396002266 Iron-sulfur protein interface; other site 585396002267 proximal quinone binding site [chemical binding]; other site 585396002268 SdhD (CybS) interface [polypeptide binding]; other site 585396002269 proximal heme binding site [chemical binding]; other site 585396002270 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 585396002271 SdhC subunit interface [polypeptide binding]; other site 585396002272 proximal heme binding site [chemical binding]; other site 585396002273 cardiolipin binding site; other site 585396002274 Iron-sulfur protein interface; other site 585396002275 proximal quinone binding site [chemical binding]; other site 585396002276 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 585396002277 L-aspartate oxidase; Provisional; Region: PRK06175 585396002278 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585396002279 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 585396002280 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 585396002281 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 585396002282 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 585396002283 TPP-binding site [chemical binding]; other site 585396002284 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 585396002285 dimer interface [polypeptide binding]; other site 585396002286 PYR/PP interface [polypeptide binding]; other site 585396002287 TPP binding site [chemical binding]; other site 585396002288 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 585396002289 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585396002290 E3 interaction surface; other site 585396002291 lipoyl attachment site [posttranslational modification]; other site 585396002292 e3 binding domain; Region: E3_binding; pfam02817 585396002293 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 585396002294 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 585396002295 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 585396002296 CoA-ligase; Region: Ligase_CoA; pfam00549 585396002297 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 585396002298 CoA binding domain; Region: CoA_binding; smart00881 585396002299 CoA-ligase; Region: Ligase_CoA; pfam00549 585396002300 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 585396002301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396002302 DNA-binding site [nucleotide binding]; DNA binding site 585396002303 UTRA domain; Region: UTRA; pfam07702 585396002304 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 585396002305 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585396002306 active site 585396002307 phosphorylation site [posttranslational modification] 585396002308 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585396002309 active site 585396002310 P-loop; other site 585396002311 phosphorylation site [posttranslational modification] 585396002312 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 585396002313 alpha-mannosidase; Provisional; Region: PRK09819 585396002314 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 585396002315 active site 585396002316 metal binding site [ion binding]; metal-binding site 585396002317 catalytic site [active] 585396002318 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 585396002319 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 585396002320 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 585396002321 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 585396002322 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 585396002323 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 585396002324 hypothetical protein; Provisional; Region: PRK10588 585396002325 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 585396002326 active site 585396002327 colicin uptake protein TolQ; Provisional; Region: PRK10801 585396002328 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 585396002329 colicin uptake protein TolR; Provisional; Region: PRK11024 585396002330 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 585396002331 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 585396002332 TolA C-terminal; Region: TolA; pfam06519 585396002333 translocation protein TolB; Provisional; Region: tolB; PRK03629 585396002334 TolB amino-terminal domain; Region: TolB_N; pfam04052 585396002335 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585396002336 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585396002337 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585396002338 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 585396002339 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585396002340 ligand binding site [chemical binding]; other site 585396002341 tol-pal system protein YbgF; Provisional; Region: PRK10803 585396002342 Tetratricopeptide repeat; Region: TPR_6; pfam13174 585396002343 Tetratricopeptide repeat; Region: TPR_6; pfam13174 585396002344 quinolinate synthetase; Provisional; Region: PRK09375 585396002345 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 585396002346 zinc transporter ZitB; Provisional; Region: PRK03557 585396002347 YbgS-like protein; Region: YbgS; pfam13985 585396002348 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 585396002349 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585396002350 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585396002351 catalytic core [active] 585396002352 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585396002353 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 585396002354 active site 585396002355 catalytic residues [active] 585396002356 galactokinase; Provisional; Region: PRK05101 585396002357 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 585396002358 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585396002359 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 585396002360 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 585396002361 dimer interface [polypeptide binding]; other site 585396002362 active site 585396002363 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 585396002364 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 585396002365 NAD binding site [chemical binding]; other site 585396002366 homodimer interface [polypeptide binding]; other site 585396002367 active site 585396002368 substrate binding site [chemical binding]; other site 585396002369 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 585396002370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 585396002371 Walker A/P-loop; other site 585396002372 ATP binding site [chemical binding]; other site 585396002373 Q-loop/lid; other site 585396002374 ABC transporter signature motif; other site 585396002375 Walker B; other site 585396002376 D-loop; other site 585396002377 H-loop/switch region; other site 585396002378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396002379 Walker A/P-loop; other site 585396002380 ATP binding site [chemical binding]; other site 585396002381 Q-loop/lid; other site 585396002382 ABC transporter signature motif; other site 585396002383 Walker B; other site 585396002384 D-loop; other site 585396002385 H-loop/switch region; other site 585396002386 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 585396002387 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 585396002388 molybdenum-pterin binding domain; Region: Mop; TIGR00638 585396002389 TOBE domain; Region: TOBE; pfam03459 585396002390 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 585396002391 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 585396002392 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396002393 substrate binding pocket [chemical binding]; other site 585396002394 membrane-bound complex binding site; other site 585396002395 hinge residues; other site 585396002396 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 585396002397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396002398 putative PBP binding loops; other site 585396002399 ABC-ATPase subunit interface; other site 585396002400 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 585396002401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396002402 Walker A/P-loop; other site 585396002403 ATP binding site [chemical binding]; other site 585396002404 Q-loop/lid; other site 585396002405 ABC transporter signature motif; other site 585396002406 Walker B; other site 585396002407 D-loop; other site 585396002408 H-loop/switch region; other site 585396002409 molybdenum-pterin binding domain; Region: Mop; TIGR00638 585396002410 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 585396002411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396002412 motif II; other site 585396002413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396002414 6-phosphogluconolactonase; Provisional; Region: PRK11028 585396002415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585396002416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396002417 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 585396002418 putative dimerization interface [polypeptide binding]; other site 585396002419 conserved predicted protein, C-terminal truncated 585396002420 conserved predicted protein, C-terminal part 585396002421 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585396002422 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585396002423 transmembrane helices; other site 585396002424 putative hydratase; Provisional; Region: PRK11413 585396002425 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 585396002426 substrate binding site [chemical binding]; other site 585396002427 ligand binding site [chemical binding]; other site 585396002428 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 585396002429 substrate binding site [chemical binding]; other site 585396002430 acyl-CoA thioesterase; Provisional; Region: PRK10531 585396002431 putative pectinesterase; Region: PLN02432; cl01911 585396002432 Prophage ECO111_P02, lambda-like phage 585396002433 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 585396002434 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 585396002435 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 585396002436 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 585396002437 dimer interface [polypeptide binding]; other site 585396002438 active site 585396002439 Int/Topo IB signature motif; other site 585396002440 Prophage ECO111_P02; putative endolysin, C-terminal part 585396002441 putative transposase OrfB; Reviewed; Region: PHA02517 585396002442 HTH-like domain; Region: HTH_21; pfam13276 585396002443 Integrase core domain; Region: rve; pfam00665 585396002444 Integrase core domain; Region: rve_3; pfam13683 585396002445 Transposase; Region: HTH_Tnp_1; cl17663 585396002446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396002447 Lysis protein S; Region: Lysis_S; pfam04971 585396002448 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585396002449 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585396002450 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 585396002451 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 585396002452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 585396002453 Phage NinH protein; Region: Phage_NinH; pfam06322 585396002454 Endodeoxyribonuclease RusA; Region: RusA; cl01885 585396002455 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 585396002456 NinF protein; Region: NinF; pfam05810 585396002457 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 585396002458 NinB protein; Region: NinB; pfam05772 585396002459 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 585396002460 Prophage ECO111_P02; putative transposase OrfA protein of insertion sequence IS629, C-terminal fragment 585396002461 putative transposase OrfB; Reviewed; Region: PHA02517 585396002462 HTH-like domain; Region: HTH_21; pfam13276 585396002463 Integrase core domain; Region: rve; pfam00665 585396002464 Integrase core domain; Region: rve_3; pfam13683 585396002465 Prophage ECO111_P02; predicted portal protein, C-terminal fragment 585396002466 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 585396002467 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 585396002468 tandem repeat interface [polypeptide binding]; other site 585396002469 oligomer interface [polypeptide binding]; other site 585396002470 active site residues [active] 585396002471 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585396002472 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585396002473 DNA packaging protein FI; Region: Packaging_FI; pfam14000 585396002474 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 585396002475 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585396002476 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585396002477 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585396002478 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585396002479 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 585396002480 Minor tail protein T; Region: Phage_tail_T; cl05636 585396002481 Phage-related minor tail protein [Function unknown]; Region: COG5281 585396002482 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585396002483 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585396002484 Phage-related protein [Function unknown]; Region: COG4718 585396002485 Phage minor tail protein L; Region: Phage_tail_L; cl01908 585396002486 Phage minor tail protein L; Region: Phage_tail_L; cl01908 585396002487 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585396002488 MPN+ (JAMM) motif; other site 585396002489 Zinc-binding site [ion binding]; other site 585396002490 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585396002491 NlpC/P60 family; Region: NLPC_P60; cl17555 585396002492 Phage-related protein, tail component [Function unknown]; Region: COG4723 585396002493 Phage-related protein, tail component [Function unknown]; Region: COG4733 585396002494 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585396002495 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585396002496 Fibronectin type III protein; Region: DUF3672; pfam12421 585396002497 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585396002498 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585396002499 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585396002500 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396002501 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396002502 Prophage ECO111_P02; Cycle-inhibiting factor Cif, non-functional due to frame shift mutations 585396002503 Prophage ECO111_P02; part of site-specific recombinase, phage integrase family 585396002504 Prophage ECO111_P02; probably non-functional due to a frame shift mutation, T3SS secreted effector NleG-homolog, C-terminal part 585396002505 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 585396002506 substrate binding site [chemical binding]; other site 585396002507 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 585396002508 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585396002509 inhibitor-cofactor binding pocket; inhibition site 585396002510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396002511 catalytic residue [active] 585396002512 biotin synthase; Provisional; Region: PRK15108 585396002513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396002514 FeS/SAM binding site; other site 585396002515 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 585396002516 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585396002517 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 585396002518 substrate-cofactor binding pocket; other site 585396002519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396002520 catalytic residue [active] 585396002521 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 585396002522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396002523 S-adenosylmethionine binding site [chemical binding]; other site 585396002524 AAA domain; Region: AAA_26; pfam13500 585396002525 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585396002526 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 585396002527 ADP binding site [chemical binding]; other site 585396002528 excinuclease ABC subunit B; Provisional; Region: PRK05298 585396002529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585396002530 ATP binding site [chemical binding]; other site 585396002531 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396002532 nucleotide binding region [chemical binding]; other site 585396002533 ATP-binding site [chemical binding]; other site 585396002534 Ultra-violet resistance protein B; Region: UvrB; pfam12344 585396002535 UvrB/uvrC motif; Region: UVR; pfam02151 585396002536 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 585396002537 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 585396002538 putative substrate binding pocket [chemical binding]; other site 585396002539 dimer interface [polypeptide binding]; other site 585396002540 phosphate binding site [ion binding]; other site 585396002541 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 585396002542 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396002543 FeS/SAM binding site; other site 585396002544 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 585396002545 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 585396002546 MPT binding site; other site 585396002547 trimer interface [polypeptide binding]; other site 585396002548 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 585396002549 trimer interface [polypeptide binding]; other site 585396002550 dimer interface [polypeptide binding]; other site 585396002551 putative active site [active] 585396002552 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 585396002553 MoaE interaction surface [polypeptide binding]; other site 585396002554 MoeB interaction surface [polypeptide binding]; other site 585396002555 thiocarboxylated glycine; other site 585396002556 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 585396002557 MoaE homodimer interface [polypeptide binding]; other site 585396002558 MoaD interaction [polypeptide binding]; other site 585396002559 active site residues [active] 585396002560 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585396002561 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 585396002562 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585396002563 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 585396002564 Predicted integral membrane protein [Function unknown]; Region: COG0392 585396002565 cardiolipin synthase 2; Provisional; Region: PRK11263 585396002566 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 585396002567 putative active site [active] 585396002568 catalytic site [active] 585396002569 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 585396002570 putative active site [active] 585396002571 catalytic site [active] 585396002572 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 585396002573 putative catalytic site [active] 585396002574 putative metal binding site [ion binding]; other site 585396002575 putative phosphate binding site [ion binding]; other site 585396002576 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 585396002577 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585396002578 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 585396002579 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585396002580 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 585396002581 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 585396002582 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585396002583 Walker A/P-loop; other site 585396002584 ATP binding site [chemical binding]; other site 585396002585 Q-loop/lid; other site 585396002586 ABC transporter signature motif; other site 585396002587 Walker B; other site 585396002588 D-loop; other site 585396002589 H-loop/switch region; other site 585396002590 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 585396002591 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585396002592 Walker A/P-loop; other site 585396002593 ATP binding site [chemical binding]; other site 585396002594 Q-loop/lid; other site 585396002595 ABC transporter signature motif; other site 585396002596 Walker B; other site 585396002597 D-loop; other site 585396002598 H-loop/switch region; other site 585396002599 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 585396002600 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396002601 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396002602 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 585396002603 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 585396002604 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 585396002605 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585396002606 ATP binding site [chemical binding]; other site 585396002607 Mg++ binding site [ion binding]; other site 585396002608 motif III; other site 585396002609 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396002610 nucleotide binding region [chemical binding]; other site 585396002611 ATP-binding site [chemical binding]; other site 585396002612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 585396002613 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 585396002614 DEAD_2; Region: DEAD_2; pfam06733 585396002615 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 585396002616 glycosyl transferase family protein; Provisional; Region: PRK08136 585396002617 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585396002618 putative dehydrogenase; Provisional; Region: PRK10098 585396002619 hypothetical protein; Provisional; Region: PRK10259 585396002620 hypothetical protein; Provisional; Region: PRK11019 585396002621 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 585396002622 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 585396002623 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585396002624 N-terminal plug; other site 585396002625 ligand-binding site [chemical binding]; other site 585396002626 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585396002627 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 585396002628 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 585396002629 putative mechanosensitive channel protein; Provisional; Region: PRK11465 585396002630 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585396002631 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 585396002632 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585396002633 Walker A/P-loop; other site 585396002634 ATP binding site [chemical binding]; other site 585396002635 Q-loop/lid; other site 585396002636 ABC transporter signature motif; other site 585396002637 Walker B; other site 585396002638 D-loop; other site 585396002639 H-loop/switch region; other site 585396002640 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585396002641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396002642 dimer interface [polypeptide binding]; other site 585396002643 conserved gate region; other site 585396002644 putative PBP binding loops; other site 585396002645 ABC-ATPase subunit interface; other site 585396002646 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 585396002647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396002648 substrate binding pocket [chemical binding]; other site 585396002649 membrane-bound complex binding site; other site 585396002650 hinge residues; other site 585396002651 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 585396002652 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 585396002653 dimerization interface [polypeptide binding]; other site 585396002654 DPS ferroxidase diiron center [ion binding]; other site 585396002655 ion pore; other site 585396002656 threonine and homoserine efflux system; Provisional; Region: PRK10532 585396002657 EamA-like transporter family; Region: EamA; pfam00892 585396002658 outer membrane protein X; Provisional; Region: ompX; PRK09408 585396002659 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 585396002660 Sulfatase; Region: Sulfatase; pfam00884 585396002661 manganese transport regulator MntR; Provisional; Region: PRK11050 585396002662 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 585396002663 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 585396002664 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585396002665 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 585396002666 transmembrane helices; other site 585396002667 L,D-transpeptidase; Provisional; Region: PRK10260 585396002668 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585396002669 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585396002670 DNA methylase; Region: N6_N4_Mtase; pfam01555 585396002671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396002672 S-adenosylmethionine binding site [chemical binding]; other site 585396002673 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 585396002674 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 585396002675 catalytic residues [active] 585396002676 catalytic nucleophile [active] 585396002677 Presynaptic Site I dimer interface [polypeptide binding]; other site 585396002678 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 585396002679 Synaptic Flat tetramer interface [polypeptide binding]; other site 585396002680 Synaptic Site I dimer interface [polypeptide binding]; other site 585396002681 DNA binding site [nucleotide binding] 585396002682 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 585396002683 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 585396002684 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585396002685 active site 585396002686 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585396002687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396002688 non-specific DNA binding site [nucleotide binding]; other site 585396002689 salt bridge; other site 585396002690 sequence-specific DNA binding site [nucleotide binding]; other site 585396002691 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 585396002692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396002693 Walker A/P-loop; other site 585396002694 ATP binding site [chemical binding]; other site 585396002695 Q-loop/lid; other site 585396002696 ABC transporter signature motif; other site 585396002697 Walker B; other site 585396002698 D-loop; other site 585396002699 H-loop/switch region; other site 585396002700 ABC transporter; Region: ABC_tran_2; pfam12848 585396002701 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585396002702 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 585396002703 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 585396002704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396002705 active site 585396002706 motif I; other site 585396002707 motif II; other site 585396002708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396002709 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 585396002710 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 585396002711 dimer interface [polypeptide binding]; other site 585396002712 active site 585396002713 glycine loop; other site 585396002714 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 585396002715 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 585396002716 active site 585396002717 intersubunit interactions; other site 585396002718 catalytic residue [active] 585396002719 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 585396002720 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 585396002721 ATP binding site [chemical binding]; other site 585396002722 substrate interface [chemical binding]; other site 585396002723 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 585396002724 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 585396002725 dimer interface [polypeptide binding]; other site 585396002726 putative functional site; other site 585396002727 putative MPT binding site; other site 585396002728 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 585396002729 catalytic nucleophile [active] 585396002730 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 585396002731 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396002732 Walker A/P-loop; other site 585396002733 ATP binding site [chemical binding]; other site 585396002734 Q-loop/lid; other site 585396002735 ABC transporter signature motif; other site 585396002736 Walker B; other site 585396002737 D-loop; other site 585396002738 H-loop/switch region; other site 585396002739 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585396002740 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396002741 Walker A/P-loop; other site 585396002742 ATP binding site [chemical binding]; other site 585396002743 Q-loop/lid; other site 585396002744 ABC transporter signature motif; other site 585396002745 Walker B; other site 585396002746 D-loop; other site 585396002747 H-loop/switch region; other site 585396002748 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 585396002749 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 585396002750 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 585396002751 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 585396002752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396002753 dimer interface [polypeptide binding]; other site 585396002754 conserved gate region; other site 585396002755 putative PBP binding loops; other site 585396002756 ABC-ATPase subunit interface; other site 585396002757 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 585396002758 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585396002759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396002760 dimer interface [polypeptide binding]; other site 585396002761 conserved gate region; other site 585396002762 putative PBP binding loops; other site 585396002763 ABC-ATPase subunit interface; other site 585396002764 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396002765 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585396002766 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396002767 metal binding site [ion binding]; metal-binding site 585396002768 active site 585396002769 I-site; other site 585396002770 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 585396002771 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 585396002772 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396002773 FeS/SAM binding site; other site 585396002774 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 585396002775 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 585396002776 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 585396002777 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 585396002778 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 585396002779 putative C-terminal domain interface [polypeptide binding]; other site 585396002780 putative GSH binding site (G-site) [chemical binding]; other site 585396002781 putative dimer interface [polypeptide binding]; other site 585396002782 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 585396002783 N-terminal domain interface [polypeptide binding]; other site 585396002784 dimer interface [polypeptide binding]; other site 585396002785 substrate binding pocket (H-site) [chemical binding]; other site 585396002786 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 585396002787 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585396002788 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 585396002789 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 585396002790 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585396002791 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585396002792 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 585396002793 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585396002794 active site 585396002795 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 585396002796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396002797 putative substrate translocation pore; other site 585396002798 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 585396002799 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396002800 active site 585396002801 motif I; other site 585396002802 motif II; other site 585396002803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396002804 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 585396002805 predicted transporter, C-terminal part 585396002806 predicted transporter, N-terminal part 585396002807 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 585396002808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585396002809 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 585396002810 putative transporter; Provisional; Region: PRK04972 585396002811 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 585396002812 TrkA-C domain; Region: TrkA_C; pfam02080 585396002813 TrkA-C domain; Region: TrkA_C; pfam02080 585396002814 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 585396002815 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 585396002816 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 585396002817 GSH binding site [chemical binding]; other site 585396002818 catalytic residues [active] 585396002819 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 585396002820 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 585396002821 dimer interface [polypeptide binding]; other site 585396002822 FMN binding site [chemical binding]; other site 585396002823 NADPH bind site [chemical binding]; other site 585396002824 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 585396002825 RimK-like ATP-grasp domain; Region: RimK; pfam08443 585396002826 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 585396002827 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 585396002828 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 585396002829 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 585396002830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396002831 Walker A/P-loop; other site 585396002832 ATP binding site [chemical binding]; other site 585396002833 Q-loop/lid; other site 585396002834 ABC transporter signature motif; other site 585396002835 Walker B; other site 585396002836 D-loop; other site 585396002837 H-loop/switch region; other site 585396002838 TOBE domain; Region: TOBE_2; pfam08402 585396002839 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 585396002840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396002841 dimer interface [polypeptide binding]; other site 585396002842 conserved gate region; other site 585396002843 putative PBP binding loops; other site 585396002844 ABC-ATPase subunit interface; other site 585396002845 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585396002846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396002847 dimer interface [polypeptide binding]; other site 585396002848 conserved gate region; other site 585396002849 putative PBP binding loops; other site 585396002850 ABC-ATPase subunit interface; other site 585396002851 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 585396002852 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 585396002853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396002854 S-adenosylmethionine binding site [chemical binding]; other site 585396002855 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 585396002856 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396002857 substrate binding pocket [chemical binding]; other site 585396002858 membrane-bound complex binding site; other site 585396002859 hinge residues; other site 585396002860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396002861 dimer interface [polypeptide binding]; other site 585396002862 conserved gate region; other site 585396002863 putative PBP binding loops; other site 585396002864 ABC-ATPase subunit interface; other site 585396002865 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585396002866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396002867 dimer interface [polypeptide binding]; other site 585396002868 conserved gate region; other site 585396002869 putative PBP binding loops; other site 585396002870 ABC-ATPase subunit interface; other site 585396002871 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 585396002872 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396002873 substrate binding pocket [chemical binding]; other site 585396002874 membrane-bound complex binding site; other site 585396002875 hinge residues; other site 585396002876 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 585396002877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396002878 Walker A/P-loop; other site 585396002879 ATP binding site [chemical binding]; other site 585396002880 Q-loop/lid; other site 585396002881 ABC transporter signature motif; other site 585396002882 Walker B; other site 585396002883 D-loop; other site 585396002884 H-loop/switch region; other site 585396002885 putative lipoprotein; Provisional; Region: PRK10533 585396002886 hypothetical protein; Provisional; Region: PRK02877 585396002887 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 585396002888 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 585396002889 amidase catalytic site [active] 585396002890 Zn binding residues [ion binding]; other site 585396002891 substrate binding site [chemical binding]; other site 585396002892 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585396002893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585396002894 NAD(P) binding site [chemical binding]; other site 585396002895 active site 585396002896 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 585396002897 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 585396002898 putative NAD(P) binding site [chemical binding]; other site 585396002899 putative active site [active] 585396002900 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 585396002901 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 585396002902 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 585396002903 tetramer interface [polypeptide binding]; other site 585396002904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396002905 catalytic residue [active] 585396002906 pyruvate dehydrogenase; Provisional; Region: PRK09124 585396002907 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 585396002908 PYR/PP interface [polypeptide binding]; other site 585396002909 dimer interface [polypeptide binding]; other site 585396002910 tetramer interface [polypeptide binding]; other site 585396002911 TPP binding site [chemical binding]; other site 585396002912 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585396002913 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 585396002914 TPP-binding site [chemical binding]; other site 585396002915 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 585396002916 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 585396002917 FAD binding pocket [chemical binding]; other site 585396002918 FAD binding motif [chemical binding]; other site 585396002919 phosphate binding motif [ion binding]; other site 585396002920 beta-alpha-beta structure motif; other site 585396002921 NAD binding pocket [chemical binding]; other site 585396002922 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585396002923 catalytic loop [active] 585396002924 iron binding site [ion binding]; other site 585396002925 hybrid cluster protein; Provisional; Region: PRK05290 585396002926 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585396002927 ACS interaction site; other site 585396002928 CODH interaction site; other site 585396002929 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 585396002930 hybrid metal cluster; other site 585396002931 Predicted membrane protein [Function unknown]; Region: COG2431 585396002932 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 585396002933 amphipathic channel; other site 585396002934 Asn-Pro-Ala signature motifs; other site 585396002935 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 585396002936 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 585396002937 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 585396002938 putative active site [active] 585396002939 putative metal-binding site [ion binding]; other site 585396002940 Protein of unknown function (DUF535); Region: DUF535; pfam04393 585396002941 macrolide transporter subunit MacA; Provisional; Region: PRK11578 585396002942 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396002943 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396002944 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 585396002945 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585396002946 Walker A/P-loop; other site 585396002947 ATP binding site [chemical binding]; other site 585396002948 Q-loop/lid; other site 585396002949 ABC transporter signature motif; other site 585396002950 Walker B; other site 585396002951 D-loop; other site 585396002952 H-loop/switch region; other site 585396002953 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585396002954 FtsX-like permease family; Region: FtsX; pfam02687 585396002955 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585396002956 DNA-binding site [nucleotide binding]; DNA binding site 585396002957 RNA-binding motif; other site 585396002958 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 585396002959 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 585396002960 Clp amino terminal domain; Region: Clp_N; pfam02861 585396002961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396002962 Walker A motif; other site 585396002963 ATP binding site [chemical binding]; other site 585396002964 Walker B motif; other site 585396002965 arginine finger; other site 585396002966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396002967 Walker A motif; other site 585396002968 ATP binding site [chemical binding]; other site 585396002969 Walker B motif; other site 585396002970 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 585396002971 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 585396002972 rRNA binding site [nucleotide binding]; other site 585396002973 predicted 30S ribosome binding site; other site 585396002974 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 585396002975 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 585396002976 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585396002977 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 585396002978 Walker A/P-loop; other site 585396002979 ATP binding site [chemical binding]; other site 585396002980 Q-loop/lid; other site 585396002981 ABC transporter signature motif; other site 585396002982 Walker B; other site 585396002983 D-loop; other site 585396002984 H-loop/switch region; other site 585396002985 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 585396002986 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585396002987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396002988 Walker A/P-loop; other site 585396002989 ATP binding site [chemical binding]; other site 585396002990 Q-loop/lid; other site 585396002991 ABC transporter signature motif; other site 585396002992 Walker B; other site 585396002993 D-loop; other site 585396002994 H-loop/switch region; other site 585396002995 thioredoxin reductase; Provisional; Region: PRK10262 585396002996 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585396002997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396002998 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 585396002999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585396003000 putative DNA binding site [nucleotide binding]; other site 585396003001 putative Zn2+ binding site [ion binding]; other site 585396003002 AsnC family; Region: AsnC_trans_reg; pfam01037 585396003003 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 585396003004 DNA translocase FtsK; Provisional; Region: PRK10263 585396003005 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 585396003006 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 585396003007 periplasmic chaperone LolA; Region: lolA; TIGR00547 585396003008 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 585396003009 recombination factor protein RarA; Reviewed; Region: PRK13342 585396003010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396003011 Walker A motif; other site 585396003012 ATP binding site [chemical binding]; other site 585396003013 Walker B motif; other site 585396003014 arginine finger; other site 585396003015 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 585396003016 seryl-tRNA synthetase; Provisional; Region: PRK05431 585396003017 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 585396003018 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 585396003019 dimer interface [polypeptide binding]; other site 585396003020 active site 585396003021 motif 1; other site 585396003022 motif 2; other site 585396003023 motif 3; other site 585396003024 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 585396003025 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585396003026 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 585396003027 putative [Fe4-S4] binding site [ion binding]; other site 585396003028 putative molybdopterin cofactor binding site [chemical binding]; other site 585396003029 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 585396003030 putative molybdopterin cofactor binding site; other site 585396003031 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 585396003032 4Fe-4S binding domain; Region: Fer4; pfam00037 585396003033 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 585396003034 Isochorismatase family; Region: Isochorismatase; pfam00857 585396003035 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 585396003036 catalytic triad [active] 585396003037 dimer interface [polypeptide binding]; other site 585396003038 conserved cis-peptide bond; other site 585396003039 putative MFS family transporter protein; Provisional; Region: PRK03633 585396003040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396003041 putative substrate translocation pore; other site 585396003042 Amino acid permease; Region: AA_permease_2; pfam13520 585396003043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585396003044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396003045 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 585396003046 putative effector binding pocket; other site 585396003047 putative dimerization interface [polypeptide binding]; other site 585396003048 hypothetical protein; Provisional; Region: PRK09739 585396003049 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585396003050 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 585396003051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396003052 FeS/SAM binding site; other site 585396003053 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 585396003054 Pyruvate formate lyase 1; Region: PFL1; cd01678 585396003055 coenzyme A binding site [chemical binding]; other site 585396003056 active site 585396003057 catalytic residues [active] 585396003058 glycine loop; other site 585396003059 formate transporter; Provisional; Region: PRK10805 585396003060 uncharacterized domain; Region: TIGR00702 585396003061 YcaO-like family; Region: YcaO; pfam02624 585396003062 Predicted membrane protein [Function unknown]; Region: COG2323 585396003063 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 585396003064 homodimer interface [polypeptide binding]; other site 585396003065 substrate-cofactor binding pocket; other site 585396003066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396003067 catalytic residue [active] 585396003068 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 585396003069 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 585396003070 hinge; other site 585396003071 active site 585396003072 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 585396003073 cytidylate kinase; Provisional; Region: cmk; PRK00023 585396003074 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 585396003075 CMP-binding site; other site 585396003076 The sites determining sugar specificity; other site 585396003077 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 585396003078 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 585396003079 RNA binding site [nucleotide binding]; other site 585396003080 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 585396003081 RNA binding site [nucleotide binding]; other site 585396003082 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 585396003083 RNA binding site [nucleotide binding]; other site 585396003084 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 585396003085 RNA binding site [nucleotide binding]; other site 585396003086 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 585396003087 RNA binding site [nucleotide binding]; other site 585396003088 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585396003089 IHF dimer interface [polypeptide binding]; other site 585396003090 IHF - DNA interface [nucleotide binding]; other site 585396003091 ComEC family competence protein; Provisional; Region: PRK11539 585396003092 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 585396003093 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 585396003094 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 585396003095 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 585396003096 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585396003097 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 585396003098 Walker A/P-loop; other site 585396003099 ATP binding site [chemical binding]; other site 585396003100 Q-loop/lid; other site 585396003101 ABC transporter signature motif; other site 585396003102 Walker B; other site 585396003103 D-loop; other site 585396003104 H-loop/switch region; other site 585396003105 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 585396003106 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 585396003107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 585396003108 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 585396003109 hypothetical protein; Provisional; Region: PRK11827 585396003110 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 585396003111 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 585396003112 Ligand binding site; other site 585396003113 oligomer interface; other site 585396003114 hypothetical protein; Provisional; Region: PRK10593 585396003115 Uncharacterized conserved protein [Function unknown]; Region: COG1434 585396003116 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585396003117 putative active site [active] 585396003118 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585396003119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396003120 S-adenosylmethionine binding site [chemical binding]; other site 585396003121 condesin subunit F; Provisional; Region: PRK05260 585396003122 condesin subunit E; Provisional; Region: PRK05256 585396003123 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 585396003124 MukB N-terminal; Region: MukB; pfam04310 585396003125 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 585396003126 murein L,D-transpeptidase; Provisional; Region: PRK10594 585396003127 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 585396003128 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585396003129 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585396003130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 585396003131 Peptidase M15; Region: Peptidase_M15_3; cl01194 585396003132 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 585396003133 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 585396003134 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585396003135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396003136 homodimer interface [polypeptide binding]; other site 585396003137 catalytic residue [active] 585396003138 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585396003139 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585396003140 trimer interface [polypeptide binding]; other site 585396003141 eyelet of channel; other site 585396003142 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 585396003143 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 585396003144 putative dimer interface [polypeptide binding]; other site 585396003145 putative anticodon binding site; other site 585396003146 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 585396003147 homodimer interface [polypeptide binding]; other site 585396003148 motif 1; other site 585396003149 motif 2; other site 585396003150 active site 585396003151 motif 3; other site 585396003152 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 585396003153 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 585396003154 active site 585396003155 aminopeptidase N; Provisional; Region: pepN; PRK14015 585396003156 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 585396003157 active site 585396003158 Zn binding site [ion binding]; other site 585396003159 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 585396003160 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 585396003161 Walker A/P-loop; other site 585396003162 ATP binding site [chemical binding]; other site 585396003163 Q-loop/lid; other site 585396003164 ABC transporter signature motif; other site 585396003165 Walker B; other site 585396003166 D-loop; other site 585396003167 H-loop/switch region; other site 585396003168 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 585396003169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396003170 dimer interface [polypeptide binding]; other site 585396003171 conserved gate region; other site 585396003172 putative PBP binding loops; other site 585396003173 ABC-ATPase subunit interface; other site 585396003174 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 585396003175 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 585396003176 active site 585396003177 dimer interface [polypeptide binding]; other site 585396003178 non-prolyl cis peptide bond; other site 585396003179 insertion regions; other site 585396003180 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396003181 substrate binding pocket [chemical binding]; other site 585396003182 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 585396003183 membrane-bound complex binding site; other site 585396003184 hinge residues; other site 585396003185 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 585396003186 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585396003187 Fimbrial protein; Region: Fimbrial; cl01416 585396003188 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585396003189 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585396003190 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585396003191 outer membrane usher protein; Provisional; Region: PRK15193 585396003192 PapC N-terminal domain; Region: PapC_N; pfam13954 585396003193 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585396003194 PapC C-terminal domain; Region: PapC_C; pfam13953 585396003195 Fimbrial protein; Region: Fimbrial; cl01416 585396003196 Fimbrial protein; Region: Fimbrial; cl01416 585396003197 Fimbrial protein; Region: Fimbrial; cl01416 585396003198 putativi pili assembly chaperone; Provisional; Region: PRK11385 585396003199 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585396003200 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585396003201 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 585396003202 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 585396003203 quinone interaction residues [chemical binding]; other site 585396003204 active site 585396003205 catalytic residues [active] 585396003206 FMN binding site [chemical binding]; other site 585396003207 substrate binding site [chemical binding]; other site 585396003208 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 585396003209 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 585396003210 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 585396003211 MOSC domain; Region: MOSC; pfam03473 585396003212 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585396003213 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585396003214 catalytic loop [active] 585396003215 iron binding site [ion binding]; other site 585396003216 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 585396003217 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 585396003218 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 585396003219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396003220 S-adenosylmethionine binding site [chemical binding]; other site 585396003221 ABC transporter ATPase component; Reviewed; Region: PRK11147 585396003222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396003223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396003224 Walker A/P-loop; other site 585396003225 Walker A/P-loop; other site 585396003226 ATP binding site [chemical binding]; other site 585396003227 ATP binding site [chemical binding]; other site 585396003228 Q-loop/lid; other site 585396003229 Q-loop/lid; other site 585396003230 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585396003231 ABC transporter signature motif; other site 585396003232 Walker B; other site 585396003233 D-loop; other site 585396003234 ABC transporter; Region: ABC_tran_2; pfam12848 585396003235 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585396003236 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 585396003237 Paraquat-inducible protein A; Region: PqiA; pfam04403 585396003238 Paraquat-inducible protein A; Region: PqiA; pfam04403 585396003239 paraquat-inducible protein B; Provisional; Region: PRK10807 585396003240 mce related protein; Region: MCE; pfam02470 585396003241 mce related protein; Region: MCE; pfam02470 585396003242 mce related protein; Region: MCE; pfam02470 585396003243 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 585396003244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 585396003245 Protein of unknown function (DUF330); Region: DUF330; pfam03886 585396003246 ribosome modulation factor; Provisional; Region: PRK14563 585396003247 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 585396003248 active site 1 [active] 585396003249 dimer interface [polypeptide binding]; other site 585396003250 active site 2 [active] 585396003251 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 585396003252 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 585396003253 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 585396003254 outer membrane protein A; Reviewed; Region: PRK10808 585396003255 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 585396003256 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585396003257 ligand binding site [chemical binding]; other site 585396003258 cell division inhibitor SulA; Region: sula; TIGR00623 585396003259 conserved predicted protein, C-terminal fragment 585396003260 TIGR01666 family membrane protein; Region: YCCS 585396003261 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 585396003262 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585396003263 Predicted membrane protein [Function unknown]; Region: COG3304 585396003264 Domain of unknown function (DUF307); Region: DUF307; pfam03733 585396003265 Domain of unknown function (DUF307); Region: DUF307; pfam03733 585396003266 DNA helicase IV; Provisional; Region: helD; PRK11054 585396003267 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 585396003268 Part of AAA domain; Region: AAA_19; pfam13245 585396003269 Family description; Region: UvrD_C_2; pfam13538 585396003270 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 585396003271 active site 585396003272 dimer interfaces [polypeptide binding]; other site 585396003273 catalytic residues [active] 585396003274 hypothetical protein; Provisional; Region: PRK03641 585396003275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 585396003276 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 585396003277 heat shock protein HspQ; Provisional; Region: PRK14129 585396003278 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 585396003279 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 585396003280 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 585396003281 putative RNA binding site [nucleotide binding]; other site 585396003282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396003283 S-adenosylmethionine binding site [chemical binding]; other site 585396003284 Acylphosphatase; Region: Acylphosphatase; cl00551 585396003285 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 585396003286 sulfur transfer protein TusE; Provisional; Region: PRK11508 585396003287 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585396003288 YccA-like proteins; Region: YccA_like; cd10433 585396003289 Prophage ECO111_P03, lambda-like phage 585396003290 Prophage ECO111_P03; predicted integrase, C-terminal fragment 585396003291 Prophage ECO111_P03; predicted integrase, N-terminal part 585396003292 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 585396003293 Prophage ECO111_P03; predicted exonuclease, C-terminal fragment 585396003294 putative transposase OrfB; Reviewed; Region: PHA02517 585396003295 HTH-like domain; Region: HTH_21; pfam13276 585396003296 Integrase core domain; Region: rve; pfam00665 585396003297 Integrase core domain; Region: rve_3; pfam13683 585396003298 Transposase; Region: HTH_Tnp_1; cl17663 585396003299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396003300 Prophage ECO111_P03; putative exonuclease, N-terminal fragment 585396003301 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585396003302 DicB protein; Region: DicB; pfam05358 585396003303 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 585396003304 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 585396003305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396003306 non-specific DNA binding site [nucleotide binding]; other site 585396003307 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585396003308 salt bridge; other site 585396003309 sequence-specific DNA binding site [nucleotide binding]; other site 585396003310 Domain of unknown function (DUF3527); Region: DUF3527; pfam12043 585396003311 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585396003312 Catalytic site [active] 585396003313 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 585396003314 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585396003315 primosomal protein DnaI; Provisional; Region: PRK02854 585396003316 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 585396003317 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 585396003318 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585396003319 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585396003320 Hok/gef family; Region: HOK_GEF; pfam01848 585396003321 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585396003322 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585396003323 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585396003324 CAAX protease self-immunity; Region: Abi; pfam02517 585396003325 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585396003326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396003327 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585396003328 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585396003329 Lysis protein S; Region: Lysis_S; pfam04971 585396003330 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585396003331 catalytic residues [active] 585396003332 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585396003333 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585396003334 PerC transcriptional activator; Region: PerC; pfam06069 585396003335 putative transposase OrfB; Reviewed; Region: PHA02517 585396003336 HTH-like domain; Region: HTH_21; pfam13276 585396003337 Integrase core domain; Region: rve; pfam00665 585396003338 Integrase core domain; Region: rve_3; pfam13683 585396003339 Transposase; Region: HTH_Tnp_1; cl17663 585396003340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396003341 EspF protein repeat; Region: EspF; pfam04806 585396003342 EspF protein repeat; Region: EspF; pfam04806 585396003343 EspF protein repeat; Region: EspF; pfam04806 585396003344 EspF protein repeat; Region: EspF; pfam04806 585396003345 Prophage ECO111_P03; T3SS secreted effector EspV-homolog 585396003346 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 585396003347 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585396003348 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 585396003349 hydrogenase 1 large subunit; Provisional; Region: PRK10170 585396003350 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 585396003351 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 585396003352 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 585396003353 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 585396003354 putative substrate-binding site; other site 585396003355 nickel binding site [ion binding]; other site 585396003356 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 585396003357 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 585396003358 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 585396003359 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 585396003360 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 585396003361 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 585396003362 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 585396003363 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585396003364 catalytic core [active] 585396003365 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585396003366 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 585396003367 Chain length determinant protein; Region: Wzz; pfam02706 585396003368 Chain length determinant protein; Region: Wzz; cl15801 585396003369 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585396003370 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 585396003371 Nucleotide binding site [chemical binding]; other site 585396003372 Low molecular weight phosphatase family; Region: LMWPc; cd00115 585396003373 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 585396003374 active site 585396003375 polysaccharide export protein Wza; Provisional; Region: PRK15078 585396003376 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 585396003377 SLBB domain; Region: SLBB; pfam10531 585396003378 SLBB domain; Region: SLBB; pfam10531 585396003379 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 585396003380 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 585396003381 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 585396003382 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585396003383 DNA-binding site [nucleotide binding]; DNA binding site 585396003384 RNA-binding motif; other site 585396003385 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585396003386 DNA-binding site [nucleotide binding]; DNA binding site 585396003387 RNA-binding motif; other site 585396003388 cold shock gene; Provisional; Region: PRK09891 585396003389 GnsA/GnsB family; Region: GnsAB; pfam08178 585396003390 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 585396003391 4Fe-4S binding domain; Region: Fer4_5; pfam12801 585396003392 4Fe-4S binding domain; Region: Fer4_5; pfam12801 585396003393 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585396003394 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 585396003395 HAMP domain; Region: HAMP; pfam00672 585396003396 dimerization interface [polypeptide binding]; other site 585396003397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396003398 dimer interface [polypeptide binding]; other site 585396003399 phosphorylation site [posttranslational modification] 585396003400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396003401 ATP binding site [chemical binding]; other site 585396003402 Mg2+ binding site [ion binding]; other site 585396003403 G-X-G motif; other site 585396003404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396003405 active site 585396003406 phosphorylation site [posttranslational modification] 585396003407 intermolecular recognition site; other site 585396003408 dimerization interface [polypeptide binding]; other site 585396003409 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585396003410 putative binding surface; other site 585396003411 active site 585396003412 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 585396003413 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 585396003414 putative ligand binding site [chemical binding]; other site 585396003415 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 585396003416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396003417 active site 585396003418 phosphorylation site [posttranslational modification] 585396003419 intermolecular recognition site; other site 585396003420 dimerization interface [polypeptide binding]; other site 585396003421 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396003422 DNA binding site [nucleotide binding] 585396003423 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 585396003424 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 585396003425 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 585396003426 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585396003427 molybdopterin cofactor binding site [chemical binding]; other site 585396003428 substrate binding site [chemical binding]; other site 585396003429 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585396003430 molybdopterin cofactor binding site; other site 585396003431 chaperone protein TorD; Validated; Region: torD; PRK04976 585396003432 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 585396003433 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 585396003434 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 585396003435 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585396003436 HSP70 interaction site [polypeptide binding]; other site 585396003437 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 585396003438 substrate binding site [polypeptide binding]; other site 585396003439 dimer interface [polypeptide binding]; other site 585396003440 hypothetical protein; Provisional; Region: PRK09784 585396003441 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 585396003442 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585396003443 catalytic core [active] 585396003444 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585396003445 hypothetical protein; Provisional; Region: PRK10174 585396003446 predicted Trp repressor binding protein WrbA 585396003447 Prophage ECO111_P04, lambda-like phage 585396003448 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 585396003449 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585396003450 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 585396003451 Int/Topo IB signature motif; other site 585396003452 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 585396003453 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585396003454 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585396003455 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 585396003456 ERF superfamily; Region: ERF; pfam04404 585396003457 Catalytic domain of Protein Kinases; Region: PKc; cd00180 585396003458 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 585396003459 active site 585396003460 ATP binding site [chemical binding]; other site 585396003461 substrate binding site [chemical binding]; other site 585396003462 activation loop (A-loop); other site 585396003463 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 585396003464 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 585396003465 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396003466 non-specific DNA binding site [nucleotide binding]; other site 585396003467 salt bridge; other site 585396003468 sequence-specific DNA binding site [nucleotide binding]; other site 585396003469 Predicted transcriptional regulator [Transcription]; Region: COG2932 585396003470 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585396003471 Catalytic site [active] 585396003472 Helix-turn-helix domain; Region: HTH_17; pfam12728 585396003473 Bacteriophage CII protein; Region: Phage_CII; pfam05269 585396003474 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 585396003475 Replication protein P; Region: Phage_lambda_P; pfam06992 585396003476 NinB protein; Region: NinB; pfam05772 585396003477 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 585396003478 P63C domain; Region: P63C; pfam10546 585396003479 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 585396003480 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585396003481 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 585396003482 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 585396003483 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585396003484 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585396003485 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585396003486 Protein of unknown function (DUF826); Region: DUF826; pfam05696 585396003487 Lysis protein S; Region: Lysis_S; pfam04971 585396003488 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585396003489 catalytic residues [active] 585396003490 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 585396003491 ORF11CD3 domain; Region: ORF11CD3; pfam10549 585396003492 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585396003493 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585396003494 Bor protein; Region: Lambda_Bor; pfam06291 585396003495 large terminase protein; Provisional; Region: 17; PHA02533 585396003496 large terminase protein; Provisional; Region: 17; PHA02533 585396003497 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 585396003498 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585396003499 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585396003500 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585396003501 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396003502 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396003503 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585396003504 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585396003505 Phage-related protein, tail component [Function unknown]; Region: COG4733 585396003506 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585396003507 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585396003508 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 585396003509 Prophage ECO111_P04; predicted protein, partial 585396003510 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 585396003511 Hok/gef family; Region: HOK_GEF; pfam01848 585396003512 Hok/gef family; Region: HOK_GEF; pfam01848 585396003513 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585396003514 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585396003515 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585396003516 DksA-like zinc finger domain containing protein; Region: PHA00080 585396003517 Phage anti-repressor protein [Transcription]; Region: COG3561 585396003518 P22AR C-terminal domain; Region: P22_AR_C; pfam10548 585396003519 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 585396003520 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 585396003521 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 585396003522 putative FMN binding site [chemical binding]; other site 585396003523 pyrimidine utilization protein D; Region: RutD; TIGR03611 585396003524 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585396003525 homotrimer interaction site [polypeptide binding]; other site 585396003526 putative active site [active] 585396003527 Isochorismatase family; Region: Isochorismatase; pfam00857 585396003528 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 585396003529 catalytic triad [active] 585396003530 conserved cis-peptide bond; other site 585396003531 pyrimidine utilization protein A; Region: RutA; TIGR03612 585396003532 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 585396003533 active site 585396003534 dimer interface [polypeptide binding]; other site 585396003535 non-prolyl cis peptide bond; other site 585396003536 insertion regions; other site 585396003537 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585396003538 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 585396003539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585396003540 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 585396003541 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 585396003542 Predicted transcriptional regulator [Transcription]; Region: COG3905 585396003543 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 585396003544 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 585396003545 Glutamate binding site [chemical binding]; other site 585396003546 NAD binding site [chemical binding]; other site 585396003547 catalytic residues [active] 585396003548 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 585396003549 Na binding site [ion binding]; other site 585396003550 FTR1 family protein; Region: TIGR00145 585396003551 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 585396003552 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 585396003553 Imelysin; Region: Peptidase_M75; pfam09375 585396003554 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 585396003555 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 585396003556 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 585396003557 hypothetical protein; Provisional; Region: PRK10536 585396003558 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 585396003559 Integrative element ECO111_IE02 585396003560 integrase; Provisional; Region: PRK09692 585396003561 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585396003562 active site 585396003563 Int/Topo IB signature motif; other site 585396003564 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 585396003565 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 585396003566 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 585396003567 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585396003568 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 585396003569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 585396003570 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 585396003571 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585396003572 ATP binding site [chemical binding]; other site 585396003573 putative Mg++ binding site [ion binding]; other site 585396003574 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396003575 nucleotide binding region [chemical binding]; other site 585396003576 ATP-binding site [chemical binding]; other site 585396003577 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 585396003578 homodimer interface [polypeptide binding]; other site 585396003579 putative GKAP docking site [polypeptide binding]; other site 585396003580 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585396003581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585396003582 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585396003583 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585396003584 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585396003585 Transposase; Region: HTH_Tnp_1; cl17663 585396003586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396003587 putative transposase OrfB; Reviewed; Region: PHA02517 585396003588 HTH-like domain; Region: HTH_21; pfam13276 585396003589 Integrase core domain; Region: rve; pfam00665 585396003590 Integrase core domain; Region: rve_3; pfam13683 585396003591 Integrative element ECO111_IE02; predicted protein, N-terminal fragment 585396003592 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 585396003593 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 585396003594 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585396003595 Sulfatase; Region: Sulfatase; pfam00884 585396003596 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 585396003597 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 585396003598 alpha-gamma subunit interface [polypeptide binding]; other site 585396003599 beta-gamma subunit interface [polypeptide binding]; other site 585396003600 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 585396003601 gamma-beta subunit interface [polypeptide binding]; other site 585396003602 alpha-beta subunit interface [polypeptide binding]; other site 585396003603 urease subunit alpha; Reviewed; Region: ureC; PRK13207 585396003604 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 585396003605 subunit interactions [polypeptide binding]; other site 585396003606 active site 585396003607 flap region; other site 585396003608 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 585396003609 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 585396003610 dimer interface [polypeptide binding]; other site 585396003611 catalytic residues [active] 585396003612 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 585396003613 UreF; Region: UreF; pfam01730 585396003614 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585396003615 Integrative element ECO111_IE02; secreted autotransporter serine protease, C-terminal fragment 585396003616 Integrative element ECO111_IE02; predicted transposase OrfA protein of insertion sequence IS600, partial 585396003617 Integrative element ECO111_IE02; conserved predicted protein, N-terminal fragment 585396003618 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 585396003619 Integrative element ECO111_IE02; predicted protein, C-terminal fragment 585396003620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396003621 Transposase; Region: HTH_Tnp_1; pfam01527 585396003622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585396003623 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585396003624 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585396003625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585396003626 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585396003627 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585396003628 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585396003629 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585396003630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585396003631 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585396003632 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585396003633 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585396003634 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585396003635 Predicted transcriptional regulator [Transcription]; Region: COG2378 585396003636 Integrative element ECO111_IE02; predicted protein, C-terminal fragment 585396003637 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 585396003638 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 585396003639 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 585396003640 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585396003641 active site 585396003642 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 585396003643 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 585396003644 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 585396003645 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 585396003646 putative metal binding site [ion binding]; other site 585396003647 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 585396003648 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 585396003649 putative metal binding site [ion binding]; other site 585396003650 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 585396003651 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 585396003652 putative metal binding site [ion binding]; other site 585396003653 tellurite resistance protein terB; Region: terB; cd07176 585396003654 putative metal binding site [ion binding]; other site 585396003655 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 585396003656 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 585396003657 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 585396003658 putative metal binding site [ion binding]; other site 585396003659 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 585396003660 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 585396003661 putative metal binding site [ion binding]; other site 585396003662 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 585396003663 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 585396003664 putative metal binding site [ion binding]; other site 585396003665 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 585396003666 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 585396003667 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585396003668 N-terminal plug; other site 585396003669 ligand-binding site [chemical binding]; other site 585396003670 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 585396003671 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 585396003672 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 585396003673 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 585396003674 homodimer interface [polypeptide binding]; other site 585396003675 TDP-binding site; other site 585396003676 Integrative element ECO111_IE02; predicted ferric enterochelin esterase, C-terminal fragment 585396003677 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 585396003678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585396003679 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585396003680 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585396003681 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 585396003682 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 585396003683 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 585396003684 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 585396003685 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 585396003686 Part of AAA domain; Region: AAA_19; pfam13245 585396003687 AAA domain; Region: AAA_12; pfam13087 585396003688 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 585396003689 Integrative element ECO111_IE02; conserved predicted protein, N-terminal part 585396003690 Integrative element ECO111_IE02; conserved predicted protein, C-terminal part 585396003691 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 585396003692 ParB-like nuclease domain; Region: ParB; smart00470 585396003693 PerC transcriptional activator; Region: PerC; pfam06069 585396003694 putative transposase OrfB; Reviewed; Region: PHA02517 585396003695 HTH-like domain; Region: HTH_21; pfam13276 585396003696 Integrase core domain; Region: rve; pfam00665 585396003697 Integrase core domain; Region: rve_3; pfam13683 585396003698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396003699 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585396003700 putative substrate translocation pore; other site 585396003701 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 585396003702 IucA / IucC family; Region: IucA_IucC; pfam04183 585396003703 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 585396003704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 585396003705 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 585396003706 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 585396003707 IucA / IucC family; Region: IucA_IucC; pfam04183 585396003708 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 585396003709 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 585396003710 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585396003711 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 585396003712 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585396003713 N-terminal plug; other site 585396003714 ligand-binding site [chemical binding]; other site 585396003715 putative transposase OrfB; Reviewed; Region: PHA02517 585396003716 HTH-like domain; Region: HTH_21; pfam13276 585396003717 Integrase core domain; Region: rve; pfam00665 585396003718 Integrase core domain; Region: rve_3; pfam13683 585396003719 Transposase; Region: HTH_Tnp_1; cl17663 585396003720 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396003721 Integrative element ECO111_IE02; predicted protein, C-terminal fragment 585396003722 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585396003723 Antirestriction protein; Region: Antirestrict; pfam03230 585396003724 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585396003725 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585396003726 MPN+ (JAMM) motif; other site 585396003727 Zinc-binding site [ion binding]; other site 585396003728 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585396003729 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585396003730 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 585396003731 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 585396003732 Methyltransferase domain; Region: Methyltransf_27; pfam13708 585396003733 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 585396003734 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 585396003735 putative ligand binding site [chemical binding]; other site 585396003736 NAD binding site [chemical binding]; other site 585396003737 dimerization interface [polypeptide binding]; other site 585396003738 catalytic site [active] 585396003739 putative hydrolase; Validated; Region: PRK09248 585396003740 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 585396003741 active site 585396003742 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 585396003743 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 585396003744 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 585396003745 curli assembly protein CsgF; Provisional; Region: PRK10050 585396003746 curli assembly protein CsgE; Provisional; Region: PRK10386 585396003747 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 585396003748 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396003749 DNA binding residues [nucleotide binding] 585396003750 dimerization interface [polypeptide binding]; other site 585396003751 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 585396003752 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585396003753 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585396003754 major curlin subunit; Provisional; Region: csgA; PRK10051 585396003755 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585396003756 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585396003757 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 585396003758 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585396003759 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 585396003760 putative ADP-ribose binding site [chemical binding]; other site 585396003761 putative active site [active] 585396003762 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 585396003763 PLD-like domain; Region: PLDc_2; pfam13091 585396003764 putative active site [active] 585396003765 catalytic site [active] 585396003766 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 585396003767 PLD-like domain; Region: PLDc_2; pfam13091 585396003768 putative active site [active] 585396003769 catalytic site [active] 585396003770 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 585396003771 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585396003772 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 585396003773 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 585396003774 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 585396003775 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 585396003776 Ligand binding site; other site 585396003777 DXD motif; other site 585396003778 lipoprotein; Provisional; Region: PRK10175 585396003779 secY/secA suppressor protein; Provisional; Region: PRK11467 585396003780 drug efflux system protein MdtG; Provisional; Region: PRK09874 585396003781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396003782 putative substrate translocation pore; other site 585396003783 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585396003784 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585396003785 putative acyl-acceptor binding pocket; other site 585396003786 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 585396003787 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 585396003788 active site residue [active] 585396003789 hypothetical protein; Provisional; Region: PRK03757 585396003790 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 585396003791 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 585396003792 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 585396003793 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585396003794 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 585396003795 DNA damage-inducible protein I; Provisional; Region: PRK10597 585396003796 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 585396003797 active site 585396003798 substrate binding pocket [chemical binding]; other site 585396003799 dimer interface [polypeptide binding]; other site 585396003800 lipoprotein; Provisional; Region: PRK10598 585396003801 glutaredoxin 2; Provisional; Region: PRK10387 585396003802 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 585396003803 C-terminal domain interface [polypeptide binding]; other site 585396003804 GSH binding site (G-site) [chemical binding]; other site 585396003805 catalytic residues [active] 585396003806 putative dimer interface [polypeptide binding]; other site 585396003807 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 585396003808 N-terminal domain interface [polypeptide binding]; other site 585396003809 multidrug resistance protein MdtH; Provisional; Region: PRK11646 585396003810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396003811 putative substrate translocation pore; other site 585396003812 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 585396003813 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 585396003814 hypothetical protein; Provisional; Region: PRK11239 585396003815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 585396003816 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585396003817 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585396003818 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585396003819 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 585396003820 MviN-like protein; Region: MVIN; pfam03023 585396003821 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 585396003822 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 585396003823 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 585396003824 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 585396003825 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 585396003826 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 585396003827 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 585396003828 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 585396003829 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585396003830 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585396003831 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 585396003832 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 585396003833 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 585396003834 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 585396003835 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585396003836 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 585396003837 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585396003838 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 585396003839 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585396003840 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 585396003841 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 585396003842 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585396003843 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585396003844 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 585396003845 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 585396003846 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 585396003847 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 585396003848 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 585396003849 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 585396003850 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 585396003851 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 585396003852 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585396003853 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 585396003854 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 585396003855 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 585396003856 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 585396003857 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 585396003858 homodimer interface [polypeptide binding]; other site 585396003859 oligonucleotide binding site [chemical binding]; other site 585396003860 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 585396003861 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 585396003862 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 585396003863 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585396003864 RNA binding surface [nucleotide binding]; other site 585396003865 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585396003866 active site 585396003867 Maf-like protein; Region: Maf; pfam02545 585396003868 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 585396003869 active site 585396003870 dimer interface [polypeptide binding]; other site 585396003871 hypothetical protein; Provisional; Region: PRK11193 585396003872 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 585396003873 putative phosphate acyltransferase; Provisional; Region: PRK05331 585396003874 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 585396003875 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 585396003876 dimer interface [polypeptide binding]; other site 585396003877 active site 585396003878 CoA binding pocket [chemical binding]; other site 585396003879 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 585396003880 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 585396003881 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 585396003882 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 585396003883 NAD(P) binding site [chemical binding]; other site 585396003884 homotetramer interface [polypeptide binding]; other site 585396003885 homodimer interface [polypeptide binding]; other site 585396003886 active site 585396003887 acyl carrier protein; Provisional; Region: acpP; PRK00982 585396003888 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 585396003889 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 585396003890 dimer interface [polypeptide binding]; other site 585396003891 active site 585396003892 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 585396003893 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 585396003894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396003895 catalytic residue [active] 585396003896 conserved hypothetical protein, YceG family; Region: TIGR00247 585396003897 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 585396003898 dimerization interface [polypeptide binding]; other site 585396003899 thymidylate kinase; Validated; Region: tmk; PRK00698 585396003900 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 585396003901 TMP-binding site; other site 585396003902 ATP-binding site [chemical binding]; other site 585396003903 DNA polymerase III subunit delta'; Validated; Region: PRK07993 585396003904 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 585396003905 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585396003906 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 585396003907 active site 585396003908 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 585396003909 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585396003910 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585396003911 active site turn [active] 585396003912 phosphorylation site [posttranslational modification] 585396003913 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 585396003914 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585396003915 N-terminal plug; other site 585396003916 ligand-binding site [chemical binding]; other site 585396003917 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 585396003918 nucleotide binding site/active site [active] 585396003919 HIT family signature motif; other site 585396003920 catalytic residue [active] 585396003921 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 585396003922 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 585396003923 putative dimer interface [polypeptide binding]; other site 585396003924 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 585396003925 thiamine kinase; Region: ycfN_thiK; TIGR02721 585396003926 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 585396003927 active site 585396003928 substrate binding site [chemical binding]; other site 585396003929 ATP binding site [chemical binding]; other site 585396003930 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 585396003931 beta-hexosaminidase; Provisional; Region: PRK05337 585396003932 conserved predicted protein, partial 585396003933 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 585396003934 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396003935 hypothetical protein; Provisional; Region: PRK11280 585396003936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585396003937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585396003938 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585396003939 L,D-transpeptidase; Provisional; Region: PRK10260 585396003940 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585396003941 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585396003942 transcription-repair coupling factor; Provisional; Region: PRK10689 585396003943 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 585396003944 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585396003945 ATP binding site [chemical binding]; other site 585396003946 putative Mg++ binding site [ion binding]; other site 585396003947 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396003948 nucleotide binding region [chemical binding]; other site 585396003949 ATP-binding site [chemical binding]; other site 585396003950 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 585396003951 Predicted membrane protein [Function unknown]; Region: COG4763 585396003952 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585396003953 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 585396003954 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585396003955 FtsX-like permease family; Region: FtsX; pfam02687 585396003956 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 585396003957 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585396003958 Walker A/P-loop; other site 585396003959 ATP binding site [chemical binding]; other site 585396003960 Q-loop/lid; other site 585396003961 ABC transporter signature motif; other site 585396003962 Walker B; other site 585396003963 D-loop; other site 585396003964 H-loop/switch region; other site 585396003965 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 585396003966 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585396003967 FtsX-like permease family; Region: FtsX; pfam02687 585396003968 fructokinase; Reviewed; Region: PRK09557 585396003969 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585396003970 nucleotide binding site [chemical binding]; other site 585396003971 NAD-dependent deacetylase; Provisional; Region: PRK00481 585396003972 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 585396003973 NAD+ binding site [chemical binding]; other site 585396003974 substrate binding site [chemical binding]; other site 585396003975 Zn binding site [ion binding]; other site 585396003976 Repair protein; Region: Repair_PSII; cl01535 585396003977 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 585396003978 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 585396003979 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 585396003980 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585396003981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396003982 dimer interface [polypeptide binding]; other site 585396003983 conserved gate region; other site 585396003984 putative PBP binding loops; other site 585396003985 ABC-ATPase subunit interface; other site 585396003986 Prophage ECO111_P05, lambda-like phage 585396003987 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 585396003988 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585396003989 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 585396003990 dimer interface [polypeptide binding]; other site 585396003991 active site 585396003992 Int/Topo IB signature motif; other site 585396003993 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 585396003994 active site 585396003995 catalytic site [active] 585396003996 substrate binding site [chemical binding]; other site 585396003997 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585396003998 DicB protein; Region: DicB; pfam05358 585396003999 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 585396004000 transcriptional repressor DicA; Reviewed; Region: PRK09706 585396004001 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585396004002 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396004003 sequence-specific DNA binding site [nucleotide binding]; other site 585396004004 salt bridge; other site 585396004005 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585396004006 Helix-turn-helix domain; Region: HTH_36; pfam13730 585396004007 primosomal protein DnaI; Provisional; Region: PRK02854 585396004008 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 585396004009 bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional; Region: pyrB; PRK13376 585396004010 Beta protein; Region: Beta_protein; pfam14350 585396004011 Prophage ECO111_P05; putative MokW protein, N-terminal part 585396004012 putative transposase OrfB; Reviewed; Region: PHA02517 585396004013 HTH-like domain; Region: HTH_21; pfam13276 585396004014 Integrase core domain; Region: rve; pfam00665 585396004015 Integrase core domain; Region: rve_3; pfam13683 585396004016 Transposase; Region: HTH_Tnp_1; cl17663 585396004017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396004018 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585396004019 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585396004020 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 585396004021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396004022 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585396004023 DNA methylase; Region: N6_N4_Mtase; pfam01555 585396004024 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585396004025 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585396004026 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585396004027 Lysis protein S; Region: Lysis_S; pfam04971 585396004028 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 585396004029 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585396004030 catalytic residues [active] 585396004031 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 585396004032 ORF11CD3 domain; Region: ORF11CD3; pfam10549 585396004033 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585396004034 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585396004035 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 585396004036 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 585396004037 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585396004038 active site 585396004039 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 585396004040 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 585396004041 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 585396004042 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 585396004043 Phage capsid family; Region: Phage_capsid; pfam05065 585396004044 Phage-related protein [Function unknown]; Region: COG4695 585396004045 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 585396004046 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 585396004047 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 585396004048 zinc binding site [ion binding]; other site 585396004049 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 585396004050 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 585396004051 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 585396004052 Immunoglobulin I-set domain; Region: I-set; pfam07679 585396004053 Immunoglobulin domain; Region: Ig_2; pfam13895 585396004054 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 585396004055 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 585396004056 Phage-related minor tail protein [Function unknown]; Region: COG5281 585396004057 tape measure domain; Region: tape_meas_nterm; TIGR02675 585396004058 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 585396004059 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585396004060 Phage-related protein [Function unknown]; Region: COG4718 585396004061 Phage-related protein [Function unknown]; Region: gp18; COG4672 585396004062 Arc-like DNA binding domain; Region: Arc; pfam03869 585396004063 Prophage ECO111_P05; putative antirepressor Ant, N-terminal part 585396004064 Prophage ECO111_P05; putative antirepressor Ant, C-terminal part 585396004065 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585396004066 MPN+ (JAMM) motif; other site 585396004067 Zinc-binding site [ion binding]; other site 585396004068 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585396004069 NlpC/P60 family; Region: NLPC_P60; cl17555 585396004070 Phage-related protein, tail component [Function unknown]; Region: COG4723 585396004071 Phage-related protein, tail component [Function unknown]; Region: COG4733 585396004072 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585396004073 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585396004074 Fibronectin type III protein; Region: DUF3672; pfam12421 585396004075 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585396004076 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585396004077 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585396004078 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396004079 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396004080 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 585396004081 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 585396004082 SopA-like central domain; Region: SopA; pfam13981 585396004083 SopA-like catalytic domain; Region: SopA_C; pfam13979 585396004084 Prophage ECO111_P05; predicted membrane protein, N-terminal fragment 585396004085 type III secretion protein GogB; Provisional; Region: PRK15386 585396004086 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585396004087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396004088 dimer interface [polypeptide binding]; other site 585396004089 conserved gate region; other site 585396004090 putative PBP binding loops; other site 585396004091 ABC-ATPase subunit interface; other site 585396004092 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 585396004093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396004094 Walker A/P-loop; other site 585396004095 ATP binding site [chemical binding]; other site 585396004096 Q-loop/lid; other site 585396004097 ABC transporter signature motif; other site 585396004098 Walker B; other site 585396004099 D-loop; other site 585396004100 H-loop/switch region; other site 585396004101 TOBE domain; Region: TOBE_2; pfam08402 585396004102 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 585396004103 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 585396004104 metal binding site [ion binding]; metal-binding site 585396004105 dimer interface [polypeptide binding]; other site 585396004106 Uncharacterized conserved protein [Function unknown]; Region: COG2850 585396004107 Cupin-like domain; Region: Cupin_8; pfam13621 585396004108 sensor protein PhoQ; Provisional; Region: PRK10815 585396004109 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 585396004110 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 585396004111 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 585396004112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396004113 ATP binding site [chemical binding]; other site 585396004114 Mg2+ binding site [ion binding]; other site 585396004115 G-X-G motif; other site 585396004116 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 585396004117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396004118 active site 585396004119 phosphorylation site [posttranslational modification] 585396004120 intermolecular recognition site; other site 585396004121 dimerization interface [polypeptide binding]; other site 585396004122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396004123 DNA binding site [nucleotide binding] 585396004124 adenylosuccinate lyase; Provisional; Region: PRK09285 585396004125 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 585396004126 tetramer interface [polypeptide binding]; other site 585396004127 active site 585396004128 putative lysogenization regulator; Reviewed; Region: PRK00218 585396004129 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 585396004130 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 585396004131 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 585396004132 nudix motif; other site 585396004133 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 585396004134 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 585396004135 probable active site [active] 585396004136 isocitrate dehydrogenase; Validated; Region: PRK07362 585396004137 isocitrate dehydrogenase; Reviewed; Region: PRK07006 585396004138 anti-adapter protein IraM; Provisional; Region: PRK09919 585396004139 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 585396004140 transcriptional regulator MirA; Provisional; Region: PRK15043 585396004141 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 585396004142 DNA binding residues [nucleotide binding] 585396004143 Sensors of blue-light using FAD; Region: BLUF; smart01034 585396004144 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396004145 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 585396004146 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 585396004147 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585396004148 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396004149 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 585396004150 predicted autotransporter outer membrane protein, N-terminal part 585396004151 predicted autotransporter outer membrane protein, C-terminal part 585396004152 putative outer membrane protein, N-terminal fragment 585396004153 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 585396004154 cell division inhibitor MinD; Provisional; Region: PRK10818 585396004155 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 585396004156 Switch I; other site 585396004157 Switch II; other site 585396004158 septum formation inhibitor; Reviewed; Region: minC; PRK03511 585396004159 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 585396004160 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 585396004161 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 585396004162 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 585396004163 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 585396004164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 585396004165 hypothetical protein; Provisional; Region: PRK10691 585396004166 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 585396004167 hypothetical protein; Provisional; Region: PRK05170 585396004168 hemolysin E; Provisional; Region: hlyE; PRK11376 585396004169 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585396004170 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585396004171 Catalytic site [active] 585396004172 DNA polymerase V, subunit C, N-terminal part 585396004173 DNA polymerase V, subunit C, C-terminal part 585396004174 disulfide bond formation protein B; Provisional; Region: PRK01749 585396004175 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585396004176 transmembrane helices; other site 585396004177 fatty acid metabolism regulator; Provisional; Region: PRK04984 585396004178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396004179 DNA-binding site [nucleotide binding]; DNA binding site 585396004180 FadR C-terminal domain; Region: FadR_C; pfam07840 585396004181 SpoVR family protein; Provisional; Region: PRK11767 585396004182 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 585396004183 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 585396004184 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396004185 alanine racemase; Reviewed; Region: dadX; PRK03646 585396004186 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 585396004187 active site 585396004188 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585396004189 substrate binding site [chemical binding]; other site 585396004190 catalytic residues [active] 585396004191 dimer interface [polypeptide binding]; other site 585396004192 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 585396004193 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 585396004194 TrkA-C domain; Region: TrkA_C; pfam02080 585396004195 Transporter associated domain; Region: CorC_HlyC; smart01091 585396004196 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 585396004197 dimer interface [polypeptide binding]; other site 585396004198 catalytic triad [active] 585396004199 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 585396004200 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585396004201 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585396004202 catalytic residue [active] 585396004203 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 585396004204 Flagellar regulator YcgR; Region: YcgR; pfam07317 585396004205 PilZ domain; Region: PilZ; pfam07238 585396004206 hypothetical protein; Provisional; Region: PRK10457 585396004207 trehalase; Provisional; Region: treA; PRK13271 585396004208 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 585396004209 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 585396004210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 585396004211 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585396004212 dimerization domain swap beta strand [polypeptide binding]; other site 585396004213 regulatory protein interface [polypeptide binding]; other site 585396004214 active site 585396004215 regulatory phosphorylation site [posttranslational modification]; other site 585396004216 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585396004217 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585396004218 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 585396004219 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 585396004220 Dak1 domain; Region: Dak1; pfam02733 585396004221 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 585396004222 PAS domain; Region: PAS; smart00091 585396004223 putative active site [active] 585396004224 heme pocket [chemical binding]; other site 585396004225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396004226 Walker A motif; other site 585396004227 ATP binding site [chemical binding]; other site 585396004228 Walker B motif; other site 585396004229 arginine finger; other site 585396004230 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585396004231 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 585396004232 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585396004233 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585396004234 GTP-binding protein YchF; Reviewed; Region: PRK09601 585396004235 YchF GTPase; Region: YchF; cd01900 585396004236 G1 box; other site 585396004237 GTP/Mg2+ binding site [chemical binding]; other site 585396004238 Switch I region; other site 585396004239 G2 box; other site 585396004240 Switch II region; other site 585396004241 G3 box; other site 585396004242 G4 box; other site 585396004243 G5 box; other site 585396004244 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 585396004245 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 585396004246 putative active site [active] 585396004247 catalytic residue [active] 585396004248 hypothetical protein; Provisional; Region: PRK10692 585396004249 putative transporter; Provisional; Region: PRK11660 585396004250 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 585396004251 Sulfate transporter family; Region: Sulfate_transp; pfam00916 585396004252 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 585396004253 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 585396004254 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 585396004255 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585396004256 active site 585396004257 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 585396004258 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585396004259 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 585396004260 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 585396004261 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 585396004262 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 585396004263 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 585396004264 tRNA; other site 585396004265 putative tRNA binding site [nucleotide binding]; other site 585396004266 putative NADP binding site [chemical binding]; other site 585396004267 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 585396004268 peptide chain release factor 1; Validated; Region: prfA; PRK00591 585396004269 This domain is found in peptide chain release factors; Region: PCRF; smart00937 585396004270 RF-1 domain; Region: RF-1; pfam00472 585396004271 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 585396004272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396004273 hypothetical protein; Provisional; Region: PRK10278 585396004274 hypothetical protein; Provisional; Region: PRK10941 585396004275 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 585396004276 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 585396004277 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585396004278 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585396004279 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585396004280 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585396004281 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 585396004282 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585396004283 cation transport regulator; Reviewed; Region: chaB; PRK09582 585396004284 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 585396004285 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 585396004286 putative active site pocket [active] 585396004287 dimerization interface [polypeptide binding]; other site 585396004288 putative catalytic residue [active] 585396004289 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 585396004290 putative invasin; Provisional; Region: PRK10177 585396004291 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585396004292 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 585396004293 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 585396004294 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585396004295 dimerization interface [polypeptide binding]; other site 585396004296 Histidine kinase; Region: HisKA_3; pfam07730 585396004297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396004298 ATP binding site [chemical binding]; other site 585396004299 Mg2+ binding site [ion binding]; other site 585396004300 G-X-G motif; other site 585396004301 transcriptional regulator NarL; Provisional; Region: PRK10651 585396004302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396004303 active site 585396004304 phosphorylation site [posttranslational modification] 585396004305 intermolecular recognition site; other site 585396004306 dimerization interface [polypeptide binding]; other site 585396004307 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396004308 DNA binding residues [nucleotide binding] 585396004309 dimerization interface [polypeptide binding]; other site 585396004310 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 585396004311 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 585396004312 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 585396004313 [4Fe-4S] binding site [ion binding]; other site 585396004314 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585396004315 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585396004316 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585396004317 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 585396004318 molybdopterin cofactor binding site; other site 585396004319 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 585396004320 4Fe-4S binding domain; Region: Fer4; cl02805 585396004321 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 585396004322 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 585396004323 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 585396004324 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 585396004325 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 585396004326 putative active site [active] 585396004327 putative substrate binding site [chemical binding]; other site 585396004328 putative cosubstrate binding site; other site 585396004329 catalytic site [active] 585396004330 SEC-C motif; Region: SEC-C; pfam02810 585396004331 hypothetical protein; Provisional; Region: PRK04233 585396004332 hypothetical protein; Provisional; Region: PRK10279 585396004333 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 585396004334 active site 585396004335 nucleophile elbow; other site 585396004336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396004337 active site 585396004338 response regulator of RpoS; Provisional; Region: PRK10693 585396004339 phosphorylation site [posttranslational modification] 585396004340 intermolecular recognition site; other site 585396004341 dimerization interface [polypeptide binding]; other site 585396004342 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 585396004343 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 585396004344 active site 585396004345 tetramer interface; other site 585396004346 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 585396004347 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585396004348 thymidine kinase; Provisional; Region: PRK04296 585396004349 predicted transposase, partial 585396004350 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 585396004351 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 585396004352 putative catalytic cysteine [active] 585396004353 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 585396004354 putative active site [active] 585396004355 metal binding site [ion binding]; metal-binding site 585396004356 hypothetical protein; Provisional; Region: PRK11111 585396004357 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 585396004358 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 585396004359 peptide binding site [polypeptide binding]; other site 585396004360 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 585396004361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396004362 dimer interface [polypeptide binding]; other site 585396004363 conserved gate region; other site 585396004364 putative PBP binding loops; other site 585396004365 ABC-ATPase subunit interface; other site 585396004366 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 585396004367 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585396004368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396004369 dimer interface [polypeptide binding]; other site 585396004370 conserved gate region; other site 585396004371 putative PBP binding loops; other site 585396004372 ABC-ATPase subunit interface; other site 585396004373 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 585396004374 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396004375 Walker A/P-loop; other site 585396004376 ATP binding site [chemical binding]; other site 585396004377 Q-loop/lid; other site 585396004378 ABC transporter signature motif; other site 585396004379 Walker B; other site 585396004380 D-loop; other site 585396004381 H-loop/switch region; other site 585396004382 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585396004383 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 585396004384 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396004385 Walker A/P-loop; other site 585396004386 ATP binding site [chemical binding]; other site 585396004387 Q-loop/lid; other site 585396004388 ABC transporter signature motif; other site 585396004389 Walker B; other site 585396004390 D-loop; other site 585396004391 H-loop/switch region; other site 585396004392 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585396004393 dsDNA-mimic protein; Reviewed; Region: PRK05094 585396004394 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 585396004395 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 585396004396 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 585396004397 putative active site [active] 585396004398 catalytic site [active] 585396004399 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 585396004400 putative active site [active] 585396004401 catalytic site [active] 585396004402 voltage-gated potassium channel; Provisional; Region: PRK10537 585396004403 Ion channel; Region: Ion_trans_2; pfam07885 585396004404 TrkA-N domain; Region: TrkA_N; pfam02254 585396004405 YciI-like protein; Reviewed; Region: PRK11370 585396004406 Prophage ECO111_P06, lambda-like phage 585396004407 multiple promoter invertase; Provisional; Region: mpi; PRK13413 585396004408 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 585396004409 catalytic residues [active] 585396004410 catalytic nucleophile [active] 585396004411 Presynaptic Site I dimer interface [polypeptide binding]; other site 585396004412 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 585396004413 Synaptic Flat tetramer interface [polypeptide binding]; other site 585396004414 Synaptic Site I dimer interface [polypeptide binding]; other site 585396004415 DNA binding site [nucleotide binding] 585396004416 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 585396004417 DNA-binding interface [nucleotide binding]; DNA binding site 585396004418 Transposase; Region: HTH_Tnp_1; cl17663 585396004419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396004420 putative transposase OrfB; Reviewed; Region: PHA02517 585396004421 HTH-like domain; Region: HTH_21; pfam13276 585396004422 Integrase core domain; Region: rve; pfam00665 585396004423 Integrase core domain; Region: rve_3; pfam13683 585396004424 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 585396004425 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 585396004426 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585396004427 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585396004428 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 585396004429 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 585396004430 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585396004431 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585396004432 Antitermination protein; Region: Antiterm; pfam03589 585396004433 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585396004434 MarR family; Region: MarR_2; cl17246 585396004435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396004436 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585396004437 DNA methylase; Region: N6_N4_Mtase; pfam01555 585396004438 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585396004439 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585396004440 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585396004441 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 585396004442 Protein of unknown function (DUF826); Region: DUF826; pfam05696 585396004443 Lysis protein S; Region: Lysis_S; pfam04971 585396004444 Prophage ECO111_P06; conserved predicted protein, N-terminal part 585396004445 Transposase; Region: HTH_Tnp_1; cl17663 585396004446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396004447 putative transposase OrfB; Reviewed; Region: PHA02517 585396004448 HTH-like domain; Region: HTH_21; pfam13276 585396004449 Integrase core domain; Region: rve; pfam00665 585396004450 Integrase core domain; Region: rve_3; pfam13683 585396004451 Prophage ECO111_P06; conserved predicted protein, C-terminal part 585396004452 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585396004453 catalytic residues [active] 585396004454 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585396004455 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585396004456 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 585396004457 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585396004458 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585396004459 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585396004460 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 585396004461 Clp protease; Region: CLP_protease; pfam00574 585396004462 oligomer interface [polypeptide binding]; other site 585396004463 active site residues [active] 585396004464 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 585396004465 Uncharacterized conserved protein [Function unknown]; Region: COG5471 585396004466 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 585396004467 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585396004468 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585396004469 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585396004470 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585396004471 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 585396004472 Minor tail protein T; Region: Phage_tail_T; cl05636 585396004473 Phage-related minor tail protein [Function unknown]; Region: COG5281 585396004474 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585396004475 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585396004476 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585396004477 Phage-related protein [Function unknown]; Region: COG4718 585396004478 Prophage ECO111_P06; putative minor tail protein, N-terminal part 585396004479 Prophage ECO111_P06; putative minor tail protein, C-terminal part 585396004480 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585396004481 MPN+ (JAMM) motif; other site 585396004482 Zinc-binding site [ion binding]; other site 585396004483 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585396004484 NlpC/P60 family; Region: NLPC_P60; cl17555 585396004485 Phage-related protein, tail component [Function unknown]; Region: COG4723 585396004486 Phage-related protein, tail component [Function unknown]; Region: COG4733 585396004487 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585396004488 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585396004489 Interdomain contacts; other site 585396004490 Cytokine receptor motif; other site 585396004491 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585396004492 Fibronectin type III protein; Region: DUF3672; pfam12421 585396004493 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585396004494 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585396004495 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585396004496 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396004497 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396004498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585396004499 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585396004500 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585396004501 Prophage ECO111_P06; putative InsB protein of insertion sequence IS1, truncated by 2bp insertion 585396004502 serine/threonine protein kinase; Provisional; Region: PRK14879 585396004503 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 585396004504 Prophage ECO111_P06; outer membrane protein W, C-terminal fragment 585396004505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 585396004506 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 585396004507 dimerization interface [polypeptide binding]; other site 585396004508 metal binding site [ion binding]; metal-binding site 585396004509 General stress protein [General function prediction only]; Region: GsiB; COG3729 585396004510 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 585396004511 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 585396004512 substrate binding site [chemical binding]; other site 585396004513 active site 585396004514 catalytic residues [active] 585396004515 heterodimer interface [polypeptide binding]; other site 585396004516 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 585396004517 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 585396004518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396004519 catalytic residue [active] 585396004520 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 585396004521 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 585396004522 active site 585396004523 ribulose/triose binding site [chemical binding]; other site 585396004524 phosphate binding site [ion binding]; other site 585396004525 substrate (anthranilate) binding pocket [chemical binding]; other site 585396004526 product (indole) binding pocket [chemical binding]; other site 585396004527 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 585396004528 active site 585396004529 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 585396004530 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 585396004531 glutamine binding [chemical binding]; other site 585396004532 catalytic triad [active] 585396004533 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585396004534 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 585396004535 anthranilate synthase component I; Provisional; Region: PRK13564 585396004536 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 585396004537 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 585396004538 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 585396004539 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 585396004540 active site 585396004541 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 585396004542 hypothetical protein; Provisional; Region: PRK11630 585396004543 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 585396004544 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585396004545 RNA binding surface [nucleotide binding]; other site 585396004546 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 585396004547 probable active site [active] 585396004548 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 585396004549 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 585396004550 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 585396004551 homodimer interface [polypeptide binding]; other site 585396004552 Walker A motif; other site 585396004553 ATP binding site [chemical binding]; other site 585396004554 hydroxycobalamin binding site [chemical binding]; other site 585396004555 Walker B motif; other site 585396004556 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 585396004557 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 585396004558 NADP binding site [chemical binding]; other site 585396004559 homodimer interface [polypeptide binding]; other site 585396004560 active site 585396004561 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 585396004562 putative inner membrane peptidase; Provisional; Region: PRK11778 585396004563 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 585396004564 tandem repeat interface [polypeptide binding]; other site 585396004565 oligomer interface [polypeptide binding]; other site 585396004566 active site residues [active] 585396004567 hypothetical protein; Provisional; Region: PRK11037 585396004568 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 585396004569 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 585396004570 active site 585396004571 interdomain interaction site; other site 585396004572 putative metal-binding site [ion binding]; other site 585396004573 nucleotide binding site [chemical binding]; other site 585396004574 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 585396004575 domain I; other site 585396004576 DNA binding groove [nucleotide binding] 585396004577 phosphate binding site [ion binding]; other site 585396004578 domain II; other site 585396004579 domain III; other site 585396004580 nucleotide binding site [chemical binding]; other site 585396004581 catalytic site [active] 585396004582 domain IV; other site 585396004583 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585396004584 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585396004585 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 585396004586 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 585396004587 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 585396004588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396004589 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 585396004590 substrate binding site [chemical binding]; other site 585396004591 putative dimerization interface [polypeptide binding]; other site 585396004592 conserved predicted protein, C-terminal fragment 585396004593 aconitate hydratase; Validated; Region: PRK09277 585396004594 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 585396004595 substrate binding site [chemical binding]; other site 585396004596 ligand binding site [chemical binding]; other site 585396004597 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 585396004598 substrate binding site [chemical binding]; other site 585396004599 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 585396004600 dimerization interface [polypeptide binding]; other site 585396004601 active site 585396004602 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585396004603 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 585396004604 active site 585396004605 Predicted membrane protein [Function unknown]; Region: COG3771 585396004606 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 585396004607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 585396004608 TPR motif; other site 585396004609 binding surface 585396004610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585396004611 binding surface 585396004612 TPR motif; other site 585396004613 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 585396004614 active site 585396004615 dimer interface [polypeptide binding]; other site 585396004616 translation initiation factor Sui1; Validated; Region: PRK06824 585396004617 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 585396004618 putative rRNA binding site [nucleotide binding]; other site 585396004619 lipoprotein; Provisional; Region: PRK10540 585396004620 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585396004621 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585396004622 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585396004623 hypothetical protein; Provisional; Region: PRK13658 585396004624 modulator of Rnase II stability, C-terminal part 585396004625 modulator of Rnase II stability, N-terminal part 585396004626 exoribonuclease II; Provisional; Region: PRK05054 585396004627 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 585396004628 RNB domain; Region: RNB; pfam00773 585396004629 S1 RNA binding domain; Region: S1; pfam00575 585396004630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 585396004631 Uncharacterized conserved protein [Function unknown]; Region: COG2128 585396004632 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 585396004633 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 585396004634 NAD binding site [chemical binding]; other site 585396004635 homotetramer interface [polypeptide binding]; other site 585396004636 homodimer interface [polypeptide binding]; other site 585396004637 substrate binding site [chemical binding]; other site 585396004638 active site 585396004639 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 585396004640 putative active site [active] 585396004641 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 585396004642 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396004643 Walker A/P-loop; other site 585396004644 ATP binding site [chemical binding]; other site 585396004645 Q-loop/lid; other site 585396004646 ABC transporter signature motif; other site 585396004647 Walker B; other site 585396004648 D-loop; other site 585396004649 H-loop/switch region; other site 585396004650 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 585396004651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396004652 Walker A/P-loop; other site 585396004653 ATP binding site [chemical binding]; other site 585396004654 Q-loop/lid; other site 585396004655 ABC transporter signature motif; other site 585396004656 Walker B; other site 585396004657 D-loop; other site 585396004658 H-loop/switch region; other site 585396004659 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585396004660 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 585396004661 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585396004662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396004663 dimer interface [polypeptide binding]; other site 585396004664 conserved gate region; other site 585396004665 putative PBP binding loops; other site 585396004666 ABC-ATPase subunit interface; other site 585396004667 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 585396004668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396004669 dimer interface [polypeptide binding]; other site 585396004670 conserved gate region; other site 585396004671 putative PBP binding loops; other site 585396004672 ABC-ATPase subunit interface; other site 585396004673 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 585396004674 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 585396004675 peptide binding site [polypeptide binding]; other site 585396004676 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 585396004677 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 585396004678 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 585396004679 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 585396004680 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 585396004681 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 585396004682 catalytic triad [active] 585396004683 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 585396004684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396004685 non-specific DNA binding site [nucleotide binding]; other site 585396004686 salt bridge; other site 585396004687 sequence-specific DNA binding site [nucleotide binding]; other site 585396004688 Cupin domain; Region: Cupin_2; pfam07883 585396004689 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 585396004690 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 585396004691 NAD(P) binding site [chemical binding]; other site 585396004692 catalytic residues [active] 585396004693 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 585396004694 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 585396004695 4-aminobutyrate transaminase; Provisional; Region: PRK09792 585396004696 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585396004697 inhibitor-cofactor binding pocket; inhibition site 585396004698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396004699 catalytic residue [active] 585396004700 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 585396004701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396004702 Walker A motif; other site 585396004703 ATP binding site [chemical binding]; other site 585396004704 Walker B motif; other site 585396004705 arginine finger; other site 585396004706 phage shock protein PspA; Provisional; Region: PRK10698 585396004707 phage shock protein B; Provisional; Region: pspB; PRK09458 585396004708 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 585396004709 phage shock protein C; Region: phageshock_pspC; TIGR02978 585396004710 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 585396004711 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585396004712 active site residue [active] 585396004713 predicted glucosyltransferase, N-terminal fragment 585396004714 predicted glucosyltransferase, C-terminal fragment 585396004715 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 585396004716 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 585396004717 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 585396004718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396004719 dimer interface [polypeptide binding]; other site 585396004720 conserved gate region; other site 585396004721 putative PBP binding loops; other site 585396004722 ABC-ATPase subunit interface; other site 585396004723 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 585396004724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396004725 dimer interface [polypeptide binding]; other site 585396004726 conserved gate region; other site 585396004727 putative PBP binding loops; other site 585396004728 ABC-ATPase subunit interface; other site 585396004729 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585396004730 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 585396004731 putative NAD(P) binding site [chemical binding]; other site 585396004732 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 585396004733 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585396004734 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585396004735 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585396004736 predicted hydrolase, N-terminal part 585396004737 predicted hydrolase, C-terminal part 585396004738 beta-phosphoglucomutase; Region: bPGM; TIGR01990 585396004739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396004740 motif II; other site 585396004741 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 585396004742 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585396004743 Walker A/P-loop; other site 585396004744 ATP binding site [chemical binding]; other site 585396004745 Q-loop/lid; other site 585396004746 ABC transporter signature motif; other site 585396004747 Walker B; other site 585396004748 D-loop; other site 585396004749 H-loop/switch region; other site 585396004750 TOBE domain; Region: TOBE_2; pfam08402 585396004751 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 585396004752 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585396004753 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396004754 DNA binding site [nucleotide binding] 585396004755 domain linker motif; other site 585396004756 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 585396004757 putative dimerization interface [polypeptide binding]; other site 585396004758 putative ligand binding site [chemical binding]; other site 585396004759 Predicted ATPase [General function prediction only]; Region: COG3106 585396004760 Predicted membrane protein [Function unknown]; Region: COG3768 585396004761 TIGR01620 family protein; Region: hyp_HI0043 585396004762 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 585396004763 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 585396004764 putative aromatic amino acid binding site; other site 585396004765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396004766 Walker A motif; other site 585396004767 ATP binding site [chemical binding]; other site 585396004768 Walker B motif; other site 585396004769 arginine finger; other site 585396004770 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 585396004771 dimer interface [polypeptide binding]; other site 585396004772 catalytic triad [active] 585396004773 peroxidatic and resolving cysteines [active] 585396004774 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 585396004775 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 585396004776 active site 585396004777 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 585396004778 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 585396004779 putative active site [active] 585396004780 Zn binding site [ion binding]; other site 585396004781 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 585396004782 NADH(P)-binding; Region: NAD_binding_10; pfam13460 585396004783 putative NAD(P) binding site [chemical binding]; other site 585396004784 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 585396004785 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 585396004786 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585396004787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585396004788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396004789 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 585396004790 putative effector binding pocket; other site 585396004791 putative dimerization interface [polypeptide binding]; other site 585396004792 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 585396004793 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 585396004794 peptide binding site [polypeptide binding]; other site 585396004795 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 585396004796 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585396004797 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 585396004798 universal stress protein UspE; Provisional; Region: PRK11175 585396004799 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585396004800 Ligand Binding Site [chemical binding]; other site 585396004801 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585396004802 Ligand Binding Site [chemical binding]; other site 585396004803 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 585396004804 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585396004805 ligand binding site [chemical binding]; other site 585396004806 flexible hinge region; other site 585396004807 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 585396004808 putative switch regulator; other site 585396004809 non-specific DNA interactions [nucleotide binding]; other site 585396004810 DNA binding site [nucleotide binding] 585396004811 sequence specific DNA binding site [nucleotide binding]; other site 585396004812 putative cAMP binding site [chemical binding]; other site 585396004813 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 585396004814 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 585396004815 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585396004816 DNA binding site [nucleotide binding] 585396004817 active site 585396004818 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 585396004819 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 585396004820 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 585396004821 amidohydrolase; Region: amidohydrolases; TIGR01891 585396004822 putative metal binding site [ion binding]; other site 585396004823 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 585396004824 amidohydrolase; Region: amidohydrolases; TIGR01891 585396004825 putative metal binding site [ion binding]; other site 585396004826 dimer interface [polypeptide binding]; other site 585396004827 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 585396004828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396004829 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 585396004830 putative substrate binding pocket [chemical binding]; other site 585396004831 putative dimerization interface [polypeptide binding]; other site 585396004832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 585396004833 Smr domain; Region: Smr; pfam01713 585396004834 PAS domain S-box; Region: sensory_box; TIGR00229 585396004835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585396004836 putative active site [active] 585396004837 heme pocket [chemical binding]; other site 585396004838 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585396004839 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396004840 metal binding site [ion binding]; metal-binding site 585396004841 active site 585396004842 I-site; other site 585396004843 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 585396004844 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 585396004845 Cl binding site [ion binding]; other site 585396004846 oligomer interface [polypeptide binding]; other site 585396004847 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 585396004848 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585396004849 ATP binding site [chemical binding]; other site 585396004850 Mg++ binding site [ion binding]; other site 585396004851 motif III; other site 585396004852 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396004853 nucleotide binding region [chemical binding]; other site 585396004854 ATP-binding site [chemical binding]; other site 585396004855 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 585396004856 putative RNA binding site [nucleotide binding]; other site 585396004857 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 585396004858 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 585396004859 Ligand Binding Site [chemical binding]; other site 585396004860 Prophage ECO111_P07, lambda-like phage 585396004861 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 585396004862 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585396004863 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 585396004864 Int/Topo IB signature motif; other site 585396004865 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 585396004866 hypothetical protein; Provisional; Region: PRK09750 585396004867 Prophage ECO111_P07; putative recombinase, N-terminal fragment 585396004868 putative transposase OrfB; Reviewed; Region: PHA02517 585396004869 HTH-like domain; Region: HTH_21; pfam13276 585396004870 Integrase core domain; Region: rve; pfam00665 585396004871 Integrase core domain; Region: rve_3; pfam13683 585396004872 Transposase; Region: HTH_Tnp_1; cl17663 585396004873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396004874 Prophage ECO111_P07; putative antirepressor, C-terminal fragment 585396004875 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585396004876 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585396004877 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 585396004878 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 585396004879 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585396004880 active site 585396004881 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 585396004882 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 585396004883 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 585396004884 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 585396004885 Phage capsid family; Region: Phage_capsid; pfam05065 585396004886 Phage-related protein [Function unknown]; Region: COG4695 585396004887 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 585396004888 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 585396004889 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 585396004890 zinc binding site [ion binding]; other site 585396004891 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 585396004892 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 585396004893 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 585396004894 Immunoglobulin I-set domain; Region: I-set; pfam07679 585396004895 Immunoglobulin domain; Region: Ig; cd00096 585396004896 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 585396004897 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 585396004898 Phage-related minor tail protein [Function unknown]; Region: COG5281 585396004899 tape measure domain; Region: tape_meas_nterm; TIGR02675 585396004900 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 585396004901 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585396004902 Phage-related protein [Function unknown]; Region: COG4718 585396004903 Phage-related protein [Function unknown]; Region: gp18; COG4672 585396004904 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585396004905 MPN+ (JAMM) motif; other site 585396004906 Zinc-binding site [ion binding]; other site 585396004907 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585396004908 NlpC/P60 family; Region: NLPC_P60; cl17555 585396004909 Phage-related protein, tail component [Function unknown]; Region: COG4723 585396004910 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 585396004911 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 585396004912 E-class dimer interface [polypeptide binding]; other site 585396004913 P-class dimer interface [polypeptide binding]; other site 585396004914 active site 585396004915 Cu2+ binding site [ion binding]; other site 585396004916 Zn2+ binding site [ion binding]; other site 585396004917 Phage-related protein, tail component [Function unknown]; Region: COG4733 585396004918 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585396004919 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585396004920 Fibronectin type III protein; Region: DUF3672; pfam12421 585396004921 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585396004922 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585396004923 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585396004924 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396004925 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396004926 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585396004927 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585396004928 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585396004929 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585396004930 Ligand Binding Site [chemical binding]; other site 585396004931 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585396004932 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585396004933 trimer interface [polypeptide binding]; other site 585396004934 eyelet of channel; other site 585396004935 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 585396004936 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 585396004937 dimer interface [polypeptide binding]; other site 585396004938 PYR/PP interface [polypeptide binding]; other site 585396004939 TPP binding site [chemical binding]; other site 585396004940 substrate binding site [chemical binding]; other site 585396004941 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 585396004942 Domain of unknown function; Region: EKR; smart00890 585396004943 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585396004944 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585396004945 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 585396004946 TPP-binding site [chemical binding]; other site 585396004947 dimer interface [polypeptide binding]; other site 585396004948 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 585396004949 Domain of unknown function (DUF333); Region: DUF333; pfam03891 585396004950 heat-inducible protein; Provisional; Region: PRK10449 585396004951 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 585396004952 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 585396004953 putative ligand binding site [chemical binding]; other site 585396004954 putative NAD binding site [chemical binding]; other site 585396004955 catalytic site [active] 585396004956 hypothetical protein; Provisional; Region: PRK10695 585396004957 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 585396004958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 585396004959 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 585396004960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396004961 Phenylacetaldehyde dehydrogenase (PAD), N-terminal part 585396004962 Phenylacetaldehyde dehydrogenase (PAD), C-terminal part 585396004963 tyramine oxidase; Provisional; Region: tynA; PRK14696 585396004964 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 585396004965 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 585396004966 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 585396004967 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 585396004968 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 585396004969 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 585396004970 substrate binding site [chemical binding]; other site 585396004971 dimer interface [polypeptide binding]; other site 585396004972 NADP binding site [chemical binding]; other site 585396004973 catalytic residues [active] 585396004974 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 585396004975 substrate binding site [chemical binding]; other site 585396004976 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 585396004977 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 585396004978 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 585396004979 phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158 585396004980 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 585396004981 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 585396004982 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 585396004983 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 585396004984 FAD binding pocket [chemical binding]; other site 585396004985 FAD binding motif [chemical binding]; other site 585396004986 phosphate binding motif [ion binding]; other site 585396004987 beta-alpha-beta structure motif; other site 585396004988 NAD(p) ribose binding residues [chemical binding]; other site 585396004989 NAD binding pocket [chemical binding]; other site 585396004990 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 585396004991 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585396004992 catalytic loop [active] 585396004993 iron binding site [ion binding]; other site 585396004994 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 585396004995 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585396004996 substrate binding site [chemical binding]; other site 585396004997 oxyanion hole (OAH) forming residues; other site 585396004998 trimer interface [polypeptide binding]; other site 585396004999 enoyl-CoA hydratase; Provisional; Region: PRK08140 585396005000 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585396005001 substrate binding site [chemical binding]; other site 585396005002 oxyanion hole (OAH) forming residues; other site 585396005003 trimer interface [polypeptide binding]; other site 585396005004 3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279 585396005005 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585396005006 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585396005007 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585396005008 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585396005009 CoenzymeA binding site [chemical binding]; other site 585396005010 subunit interaction site [polypeptide binding]; other site 585396005011 PHB binding site; other site 585396005012 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 585396005013 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585396005014 dimer interface [polypeptide binding]; other site 585396005015 active site 585396005016 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 585396005017 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 585396005018 active site 585396005019 AMP binding site [chemical binding]; other site 585396005020 homodimer interface [polypeptide binding]; other site 585396005021 acyl-activating enzyme (AAE) consensus motif; other site 585396005022 CoA binding site [chemical binding]; other site 585396005023 PaaX-like protein; Region: PaaX; pfam07848 585396005024 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 585396005025 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 585396005026 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 585396005027 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 585396005028 putative trimer interface [polypeptide binding]; other site 585396005029 putative metal binding site [ion binding]; other site 585396005030 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585396005031 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585396005032 active site 585396005033 catalytic tetrad [active] 585396005034 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 585396005035 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 585396005036 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 585396005037 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 585396005038 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 585396005039 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 585396005040 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585396005041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396005042 S-adenosylmethionine binding site [chemical binding]; other site 585396005043 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 585396005044 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585396005045 active site 585396005046 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 585396005047 active site 585396005048 catalytic residues [active] 585396005049 azoreductase; Reviewed; Region: PRK00170 585396005050 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585396005051 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 585396005052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585396005053 ATP binding site [chemical binding]; other site 585396005054 putative Mg++ binding site [ion binding]; other site 585396005055 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396005056 nucleotide binding region [chemical binding]; other site 585396005057 ATP-binding site [chemical binding]; other site 585396005058 Helicase associated domain (HA2); Region: HA2; pfam04408 585396005059 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 585396005060 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 585396005061 Uncharacterized conserved protein [Function unknown]; Region: COG1434 585396005062 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585396005063 putative active site [active] 585396005064 aldehyde dehydrogenase A, NAD-linked, N-terminal part 585396005065 aldehyde dehydrogenase A, NAD-linked, C-terminal part 585396005066 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 585396005067 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585396005068 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585396005069 cytochrome b561; Provisional; Region: PRK11513 585396005070 hypothetical protein; Provisional; Region: PRK10040 585396005071 small toxic polypeptide; Provisional; Region: PRK09738 585396005072 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 585396005073 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585396005074 dimer interface [polypeptide binding]; other site 585396005075 ligand binding site [chemical binding]; other site 585396005076 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585396005077 dimerization interface [polypeptide binding]; other site 585396005078 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585396005079 dimer interface [polypeptide binding]; other site 585396005080 putative CheW interface [polypeptide binding]; other site 585396005081 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 585396005082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396005083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585396005084 dimerization interface [polypeptide binding]; other site 585396005085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 585396005086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 585396005087 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 585396005088 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 585396005089 hypothetical protein; Provisional; Region: PRK11415 585396005090 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 585396005091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396005092 Coenzyme A binding pocket [chemical binding]; other site 585396005093 predicted enzyme, C-terminal part 585396005094 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 585396005095 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 585396005096 gating phenylalanine in ion channel; other site 585396005097 tellurite resistance protein TehB; Provisional; Region: PRK11207 585396005098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396005099 S-adenosylmethionine binding site [chemical binding]; other site 585396005100 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 585396005101 predicted transposase TnpA of insertion sequence IS609, central part 585396005102 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 585396005103 Probable transposase; Region: OrfB_IS605; pfam01385 585396005104 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 585396005105 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 585396005106 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 585396005107 benzoate transporter; Region: benE; TIGR00843 585396005108 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585396005109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396005110 non-specific DNA binding site [nucleotide binding]; other site 585396005111 salt bridge; other site 585396005112 sequence-specific DNA binding site [nucleotide binding]; other site 585396005113 Cupin domain; Region: Cupin_2; pfam07883 585396005114 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585396005115 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585396005116 Peptidase family U32; Region: Peptidase_U32; pfam01136 585396005117 Collagenase; Region: DUF3656; pfam12392 585396005118 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 585396005119 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 585396005120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396005121 sequence-specific DNA binding site [nucleotide binding]; other site 585396005122 salt bridge; other site 585396005123 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585396005124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396005125 DNA-binding site [nucleotide binding]; DNA binding site 585396005126 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585396005127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396005128 homodimer interface [polypeptide binding]; other site 585396005129 catalytic residue [active] 585396005130 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 585396005131 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 585396005132 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 585396005133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396005134 Walker A/P-loop; other site 585396005135 ATP binding site [chemical binding]; other site 585396005136 Q-loop/lid; other site 585396005137 ABC transporter signature motif; other site 585396005138 Walker B; other site 585396005139 D-loop; other site 585396005140 H-loop/switch region; other site 585396005141 TOBE domain; Region: TOBE_2; pfam08402 585396005142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396005143 dimer interface [polypeptide binding]; other site 585396005144 conserved gate region; other site 585396005145 putative PBP binding loops; other site 585396005146 ABC-ATPase subunit interface; other site 585396005147 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585396005148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396005149 ABC-ATPase subunit interface; other site 585396005150 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 585396005151 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 585396005152 tetrameric interface [polypeptide binding]; other site 585396005153 NAD binding site [chemical binding]; other site 585396005154 catalytic residues [active] 585396005155 substrate binding site [chemical binding]; other site 585396005156 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 585396005157 trimer interface [polypeptide binding]; other site 585396005158 active site 585396005159 substrate binding site [chemical binding]; other site 585396005160 CoA binding site [chemical binding]; other site 585396005161 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 585396005162 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 585396005163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 585396005164 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 585396005165 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 585396005166 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 585396005167 Prostaglandin dehydrogenases; Region: PGDH; cd05288 585396005168 NAD(P) binding site [chemical binding]; other site 585396005169 substrate binding site [chemical binding]; other site 585396005170 dimer interface [polypeptide binding]; other site 585396005171 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 585396005172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396005173 DNA-binding site [nucleotide binding]; DNA binding site 585396005174 FCD domain; Region: FCD; pfam07729 585396005175 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 585396005176 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585396005177 N-terminal plug; other site 585396005178 ligand-binding site [chemical binding]; other site 585396005179 PQQ-like domain; Region: PQQ_2; pfam13360 585396005180 L-asparagine transporter AnsP, C-terminal part 585396005181 L-asparagine transporter AnsP, N-terminal part 585396005182 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 585396005183 C-terminal domain interface [polypeptide binding]; other site 585396005184 GSH binding site (G-site) [chemical binding]; other site 585396005185 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 585396005186 dimer interface [polypeptide binding]; other site 585396005187 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 585396005188 dimer interface [polypeptide binding]; other site 585396005189 N-terminal domain interface [polypeptide binding]; other site 585396005190 substrate binding pocket (H-site) [chemical binding]; other site 585396005191 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 585396005192 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585396005193 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585396005194 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585396005195 PAAR motif; Region: PAAR_motif; cl15808 585396005196 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585396005197 RHS Repeat; Region: RHS_repeat; pfam05593 585396005198 RHS Repeat; Region: RHS_repeat; pfam05593 585396005199 RHS Repeat; Region: RHS_repeat; pfam05593 585396005200 RHS Repeat; Region: RHS_repeat; pfam05593 585396005201 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585396005202 RHS Repeat; Region: RHS_repeat; pfam05593 585396005203 RHS Repeat; Region: RHS_repeat; pfam05593 585396005204 RHS protein; Region: RHS; pfam03527 585396005205 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585396005206 RhsE, IS677, putative H repeat-associated protein 585396005207 RhsE, IS677, putative H repeat-associated protein, C-terminal fragment 585396005208 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 585396005209 active site 1 [active] 585396005210 dimer interface [polypeptide binding]; other site 585396005211 hexamer interface [polypeptide binding]; other site 585396005212 active site 2 [active] 585396005213 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 585396005214 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 585396005215 hypothetical protein; Provisional; Region: PRK10281 585396005216 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 585396005217 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 585396005218 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 585396005219 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 585396005220 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 585396005221 [4Fe-4S] binding site [ion binding]; other site 585396005222 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585396005223 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585396005224 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585396005225 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 585396005226 molybdopterin cofactor binding site; other site 585396005227 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 585396005228 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 585396005229 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 585396005230 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585396005231 aromatic amino acid exporter; Provisional; Region: PRK11689 585396005232 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 585396005233 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585396005234 [4Fe-4S] binding site [ion binding]; other site 585396005235 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585396005236 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585396005237 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 585396005238 molybdopterin cofactor binding site; other site 585396005239 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 585396005240 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 585396005241 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 585396005242 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 585396005243 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 585396005244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396005245 non-specific DNA binding site [nucleotide binding]; other site 585396005246 salt bridge; other site 585396005247 sequence-specific DNA binding site [nucleotide binding]; other site 585396005248 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 585396005249 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 585396005250 NAD binding site [chemical binding]; other site 585396005251 substrate binding site [chemical binding]; other site 585396005252 catalytic Zn binding site [ion binding]; other site 585396005253 tetramer interface [polypeptide binding]; other site 585396005254 structural Zn binding site [ion binding]; other site 585396005255 malate dehydrogenase; Provisional; Region: PRK13529 585396005256 Malic enzyme, N-terminal domain; Region: malic; pfam00390 585396005257 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 585396005258 NAD(P) binding site [chemical binding]; other site 585396005259 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 585396005260 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 585396005261 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 585396005262 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 585396005263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396005264 Walker A/P-loop; other site 585396005265 ATP binding site [chemical binding]; other site 585396005266 Q-loop/lid; other site 585396005267 ABC transporter signature motif; other site 585396005268 Walker B; other site 585396005269 D-loop; other site 585396005270 H-loop/switch region; other site 585396005271 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 585396005272 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 585396005273 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396005274 Walker A/P-loop; other site 585396005275 ATP binding site [chemical binding]; other site 585396005276 Q-loop/lid; other site 585396005277 ABC transporter signature motif; other site 585396005278 Walker B; other site 585396005279 D-loop; other site 585396005280 H-loop/switch region; other site 585396005281 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 585396005282 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 585396005283 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585396005284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396005285 dimer interface [polypeptide binding]; other site 585396005286 conserved gate region; other site 585396005287 putative PBP binding loops; other site 585396005288 ABC-ATPase subunit interface; other site 585396005289 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 585396005290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396005291 dimer interface [polypeptide binding]; other site 585396005292 conserved gate region; other site 585396005293 putative PBP binding loops; other site 585396005294 ABC-ATPase subunit interface; other site 585396005295 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 585396005296 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 585396005297 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 585396005298 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 585396005299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585396005300 putative active site [active] 585396005301 heme pocket [chemical binding]; other site 585396005302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585396005303 putative active site [active] 585396005304 heme pocket [chemical binding]; other site 585396005305 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396005306 metal binding site [ion binding]; metal-binding site 585396005307 active site 585396005308 I-site; other site 585396005309 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396005310 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 585396005311 heme-binding site [chemical binding]; other site 585396005312 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585396005313 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396005314 metal binding site [ion binding]; metal-binding site 585396005315 active site 585396005316 I-site; other site 585396005317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 585396005318 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 585396005319 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 585396005320 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 585396005321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396005322 catalytic residue [active] 585396005323 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585396005324 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 585396005325 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585396005326 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585396005327 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585396005328 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 585396005329 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 585396005330 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 585396005331 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 585396005332 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 585396005333 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 585396005334 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396005335 FeS/SAM binding site; other site 585396005336 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 585396005337 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 585396005338 Sulfatase; Region: Sulfatase; pfam00884 585396005339 transcriptional regulator YdeO; Provisional; Region: PRK09940 585396005340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396005341 putative oxidoreductase; Provisional; Region: PRK09939 585396005342 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 585396005343 putative molybdopterin cofactor binding site [chemical binding]; other site 585396005344 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 585396005345 putative molybdopterin cofactor binding site; other site 585396005346 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 585396005347 mannosyl binding site [chemical binding]; other site 585396005348 Fimbrial protein; Region: Fimbrial; pfam00419 585396005349 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585396005350 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585396005351 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585396005352 PapC N-terminal domain; Region: PapC_N; pfam13954 585396005353 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585396005354 PapC C-terminal domain; Region: PapC_C; pfam13953 585396005355 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 585396005356 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585396005357 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585396005358 Fimbrial protein; Region: Fimbrial; cl01416 585396005359 Helix-turn-helix domain; Region: HTH_18; pfam12833 585396005360 HipA N-terminal domain; Region: Couple_hipA; pfam13657 585396005361 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 585396005362 HipA-like N-terminal domain; Region: HipA_N; pfam07805 585396005363 HipA-like C-terminal domain; Region: HipA_C; pfam07804 585396005364 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585396005365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396005366 non-specific DNA binding site [nucleotide binding]; other site 585396005367 salt bridge; other site 585396005368 sequence-specific DNA binding site [nucleotide binding]; other site 585396005369 AidA-I related adhesin-like protein, partial 585396005370 predicted lipoprotein, C-terminal part 585396005371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396005372 Transposase; Region: HTH_Tnp_1; cl17663 585396005373 HTH-like domain; Region: HTH_21; pfam13276 585396005374 Integrase core domain; Region: rve; pfam00665 585396005375 DDE domain; Region: DDE_Tnp_IS240; pfam13610 585396005376 Integrase core domain; Region: rve_3; pfam13683 585396005377 predicted lipoprotein, N-terminal part 585396005378 predicted sugar kinase, N-terminal part 585396005379 transcriptional regulator LsrR; Provisional; Region: PRK15418 585396005380 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 585396005381 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 585396005382 AI2 transporter subunits of ABC superfamily: ATP-binding components, N-terminal part 585396005383 AI2 transporter subunits of ABC superfamily: ATP-binding components, C-terminal part 585396005384 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585396005385 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585396005386 TM-ABC transporter signature motif; other site 585396005387 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585396005388 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585396005389 TM-ABC transporter signature motif; other site 585396005390 AI2 transporter protein LsrB, periplasmic-binding component of ABC superfamily, C-terminal part 585396005391 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 585396005392 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 585396005393 putative active site; other site 585396005394 catalytic residue [active] 585396005395 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 585396005396 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 585396005397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396005398 S-adenosylmethionine binding site [chemical binding]; other site 585396005399 Predicted membrane protein [Function unknown]; Region: COG3781 585396005400 altronate oxidoreductase; Provisional; Region: PRK03643 585396005401 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585396005402 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585396005403 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585396005404 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396005405 metal binding site [ion binding]; metal-binding site 585396005406 active site 585396005407 I-site; other site 585396005408 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 585396005409 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 585396005410 glutaminase; Provisional; Region: PRK00971 585396005411 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 585396005412 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 585396005413 NAD(P) binding site [chemical binding]; other site 585396005414 catalytic residues [active] 585396005415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585396005416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396005417 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 585396005418 putative dimerization interface [polypeptide binding]; other site 585396005419 conserved predicted protein, N-terminal fragment 585396005420 conserved predicted protein, C-terminal part 585396005421 putative arabinose transporter; Provisional; Region: PRK03545 585396005422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396005423 putative substrate translocation pore; other site 585396005424 inner membrane protein; Provisional; Region: PRK10995 585396005425 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 585396005426 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585396005427 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 585396005428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396005429 hypothetical protein; Provisional; Region: PRK10106 585396005430 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 585396005431 beta-galactosidase; Region: BGL; TIGR03356 585396005432 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 585396005433 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585396005434 trimer interface; other site 585396005435 sugar binding site [chemical binding]; other site 585396005436 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 585396005437 active site 585396005438 methionine cluster; other site 585396005439 phosphorylation site [posttranslational modification] 585396005440 metal binding site [ion binding]; metal-binding site 585396005441 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 585396005442 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 585396005443 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 585396005444 active site 585396005445 P-loop; other site 585396005446 phosphorylation site [posttranslational modification] 585396005447 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585396005448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396005449 DNA-binding site [nucleotide binding]; DNA binding site 585396005450 UTRA domain; Region: UTRA; pfam07702 585396005451 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 585396005452 EamA-like transporter family; Region: EamA; pfam00892 585396005453 EamA-like transporter family; Region: EamA; pfam00892 585396005454 putative transporter; Provisional; Region: PRK10054 585396005455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396005456 putative substrate translocation pore; other site 585396005457 diguanylate cyclase; Provisional; Region: PRK09894 585396005458 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 585396005459 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396005460 metal binding site [ion binding]; metal-binding site 585396005461 active site 585396005462 I-site; other site 585396005463 hypothetical protein; Provisional; Region: PRK10053 585396005464 hypothetical protein; Validated; Region: PRK03657 585396005465 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 585396005466 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 585396005467 active site 585396005468 Zn binding site [ion binding]; other site 585396005469 malonic semialdehyde reductase; Provisional; Region: PRK10538 585396005470 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 585396005471 putative NAD(P) binding site [chemical binding]; other site 585396005472 homodimer interface [polypeptide binding]; other site 585396005473 homotetramer interface [polypeptide binding]; other site 585396005474 active site 585396005475 Transcriptional regulators [Transcription]; Region: GntR; COG1802 585396005476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396005477 DNA-binding site [nucleotide binding]; DNA binding site 585396005478 FCD domain; Region: FCD; pfam07729 585396005479 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 585396005480 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 585396005481 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585396005482 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585396005483 metabolite-proton symporter; Region: 2A0106; TIGR00883 585396005484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396005485 putative substrate translocation pore; other site 585396005486 Prophage ECO111_P08, lambda-like phage 585396005487 DinI-like family; Region: DinI; pfam06183 585396005488 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585396005489 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396005490 putative transposase OrfB; Reviewed; Region: PHA02517 585396005491 HTH-like domain; Region: HTH_21; pfam13276 585396005492 Integrase core domain; Region: rve; pfam00665 585396005493 Integrase core domain; Region: rve_3; pfam13683 585396005494 Transposase; Region: HTH_Tnp_1; cl17663 585396005495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396005496 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585396005497 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585396005498 Prophage ECO111_P08; predicted TciB/TerA-like protein, C-terminal fragment 585396005499 Prophage ECO111_P08; predicted TciA/TerB -like protein, partial 585396005500 Prophage ECO111_P08; predicted TciA/TerB -like protein, partial 585396005501 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 585396005502 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585396005503 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585396005504 Hok/gef family; Region: HOK_GEF; pfam01848 585396005505 Hok/gef family; Region: HOK_GEF; pfam01848 585396005506 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 585396005507 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 585396005508 Prophage ECO111_P08; predicted fimbrial minor pilin protein, partial 585396005509 Prophage ECO111_P08; predicted fimbrial minor pilin protein, partial 585396005510 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 585396005511 Pyocin large subunit [General function prediction only]; Region: COG5529 585396005512 Helix-turn-helix domain; Region: HTH_36; pfam13730 585396005513 primosomal protein DnaI; Provisional; Region: PRK02854 585396005514 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585396005515 transcriptional repressor DicA; Reviewed; Region: PRK09706 585396005516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396005517 sequence-specific DNA binding site [nucleotide binding]; other site 585396005518 salt bridge; other site 585396005519 DicB protein; Region: DicB; pfam05358 585396005520 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585396005521 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 585396005522 active site 585396005523 substrate binding site [chemical binding]; other site 585396005524 catalytic site [active] 585396005525 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 585396005526 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585396005527 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 585396005528 dimer interface [polypeptide binding]; other site 585396005529 active site 585396005530 Int/Topo IB signature motif; other site 585396005531 outer membrane protein W; Provisional; Region: PRK10959 585396005532 hypothetical protein; Provisional; Region: PRK02868 585396005533 intracellular septation protein A; Reviewed; Region: PRK00259 585396005534 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 585396005535 transport protein TonB; Provisional; Region: PRK10819 585396005536 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 585396005537 Prophage ECO111_P09, lambda-like phage 585396005538 Prophage ECO111_P09; protein predicted integrase/recombinase, N-terminal fragment 585396005539 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585396005540 Prophage ECO111_P09; predicted transposase of insertion sequence IS630, partial 585396005541 Prophage ECO111_P09; predicted transposase of insertion sequence IS630, partial 585396005542 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 585396005543 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585396005544 Prophage ECO111_P09; predicted transposase of insertion sequence IS604, partial 585396005545 Prophage ECO111_P09; T3SS secreted effector NleF-like protein, N-terminal part 585396005546 hypothetical protein; Provisional; Region: PHA03031 585396005547 Prophage ECO111_P09; predicted integrase, N-terminal part 585396005548 Prophage ECO111_P09; T3SS secreted effector NleG-homolog, partial 585396005549 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396005550 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585396005551 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585396005552 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396005553 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585396005554 Phage-related protein, tail component [Function unknown]; Region: COG4733 585396005555 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585396005556 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585396005557 Interdomain contacts; other site 585396005558 Cytokine receptor motif; other site 585396005559 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585396005560 Fibronectin type III protein; Region: DUF3672; pfam12421 585396005561 Phage-related protein, tail component [Function unknown]; Region: COG4723 585396005562 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585396005563 MPN+ (JAMM) motif; other site 585396005564 Zinc-binding site [ion binding]; other site 585396005565 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585396005566 NlpC/P60 family; Region: NLPC_P60; cl17555 585396005567 Phage-related protein [Function unknown]; Region: gp18; COG4672 585396005568 Phage-related protein [Function unknown]; Region: COG4718 585396005569 Prophage ECO111_P09; putative tail length tape measure protein, C-terminal fragment 585396005570 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 585396005571 Putative transposase; Region: Y2_Tnp; pfam04986 585396005572 Prophage ECO111_P09; putative tail length tape measure protein, N-terminal fragment 585396005573 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 585396005574 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 585396005575 Immunoglobulin I-set domain; Region: I-set; pfam07679 585396005576 Immunoglobulin domain; Region: Ig; cd00096 585396005577 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 585396005578 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 585396005579 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 585396005580 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 585396005581 Phage-related protein [Function unknown]; Region: COG4695 585396005582 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 585396005583 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 585396005584 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 585396005585 Phage capsid family; Region: Phage_capsid; pfam05065 585396005586 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 585396005587 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 585396005588 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 585396005589 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585396005590 active site 585396005591 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 585396005592 Prophage ECO111_P09; conserved predicted protein, N-terminal part 585396005593 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585396005594 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585396005595 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585396005596 catalytic residues [active] 585396005597 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 585396005598 Lysis protein S; Region: Lysis_S; pfam04971 585396005599 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585396005600 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585396005601 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 585396005602 tellurium resistance terB-like protein; Region: terB_like; cl11965 585396005603 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 585396005604 transcriptional repressor DicA; Reviewed; Region: PRK09706 585396005605 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396005606 non-specific DNA binding site [nucleotide binding]; other site 585396005607 salt bridge; other site 585396005608 sequence-specific DNA binding site [nucleotide binding]; other site 585396005609 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 585396005610 Prophage ECO111_P09; conserved predicted protein, N-terminal part 585396005611 DicB protein; Region: DicB; pfam05358 585396005612 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585396005613 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 585396005614 active site 585396005615 catalytic site [active] 585396005616 substrate binding site [chemical binding]; other site 585396005617 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 585396005618 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 585396005619 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585396005620 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 585396005621 Int/Topo IB signature motif; other site 585396005622 putative oxidoreductase; Provisional; Region: PRK10083 585396005623 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 585396005624 putative NAD(P) binding site [chemical binding]; other site 585396005625 catalytic Zn binding site [ion binding]; other site 585396005626 structural Zn binding site [ion binding]; other site 585396005627 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 585396005628 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 585396005629 putative active site pocket [active] 585396005630 putative metal binding site [ion binding]; other site 585396005631 hypothetical protein; Provisional; Region: PRK02237 585396005632 hypothetical protein; Provisional; Region: PRK13659 585396005633 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 585396005634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396005635 Coenzyme A binding pocket [chemical binding]; other site 585396005636 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 585396005637 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 585396005638 oxidoreductase subunit, N-terminal part 585396005639 oxidoreductase subunit, C-terminal part 585396005640 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 585396005641 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 585396005642 putative [Fe4-S4] binding site [ion binding]; other site 585396005643 putative molybdopterin cofactor binding site [chemical binding]; other site 585396005644 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 585396005645 putative molybdopterin cofactor binding site; other site 585396005646 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 585396005647 4Fe-4S binding domain; Region: Fer4; cl02805 585396005648 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 585396005649 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 585396005650 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585396005651 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 585396005652 Cl- selectivity filter; other site 585396005653 Cl- binding residues [ion binding]; other site 585396005654 pore gating glutamate residue; other site 585396005655 dimer interface [polypeptide binding]; other site 585396005656 putative dithiobiotin synthetase; Provisional; Region: PRK12374 585396005657 AAA domain; Region: AAA_26; pfam13500 585396005658 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 585396005659 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585396005660 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585396005661 nucleotide binding site [chemical binding]; other site 585396005662 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 585396005663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396005664 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 585396005665 dimerization interface [polypeptide binding]; other site 585396005666 substrate binding pocket [chemical binding]; other site 585396005667 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 585396005668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396005669 putative substrate translocation pore; other site 585396005670 acid shock-inducible periplasmic protein Asr, N-terminal part 585396005671 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 585396005672 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 585396005673 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 585396005674 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 585396005675 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585396005676 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 585396005677 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 585396005678 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 585396005679 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 585396005680 ligand binding site [chemical binding]; other site 585396005681 homodimer interface [polypeptide binding]; other site 585396005682 NAD(P) binding site [chemical binding]; other site 585396005683 trimer interface B [polypeptide binding]; other site 585396005684 trimer interface A [polypeptide binding]; other site 585396005685 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 585396005686 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585396005687 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585396005688 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585396005689 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 585396005690 Spore germination protein; Region: Spore_permease; cl17796 585396005691 dihydromonapterin reductase; Provisional; Region: PRK06483 585396005692 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 585396005693 NADP binding site [chemical binding]; other site 585396005694 substrate binding pocket [chemical binding]; other site 585396005695 active site 585396005696 GlpM protein; Region: GlpM; pfam06942 585396005697 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 585396005698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396005699 active site 585396005700 phosphorylation site [posttranslational modification] 585396005701 intermolecular recognition site; other site 585396005702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396005703 DNA binding site [nucleotide binding] 585396005704 sensor protein RstB; Provisional; Region: PRK10604 585396005705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585396005706 dimerization interface [polypeptide binding]; other site 585396005707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396005708 dimer interface [polypeptide binding]; other site 585396005709 phosphorylation site [posttranslational modification] 585396005710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396005711 ATP binding site [chemical binding]; other site 585396005712 Mg2+ binding site [ion binding]; other site 585396005713 G-X-G motif; other site 585396005714 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 585396005715 fumarate hydratase; Reviewed; Region: fumC; PRK00485 585396005716 Class II fumarases; Region: Fumarase_classII; cd01362 585396005717 active site 585396005718 tetramer interface [polypeptide binding]; other site 585396005719 fumarate hydratase; Provisional; Region: PRK15389 585396005720 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 585396005721 Fumarase C-terminus; Region: Fumerase_C; pfam05683 585396005722 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 585396005723 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 585396005724 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 585396005725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 585396005726 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 585396005727 putative outer membrane porin protein; Provisional; Region: PRK11379 585396005728 glucuronide transporter; Provisional; Region: PRK09848 585396005729 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 585396005730 beta-D-glucuronidase; Provisional; Region: PRK10150 585396005731 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 585396005732 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 585396005733 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 585396005734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585396005735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585396005736 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 585396005737 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 585396005738 NAD binding site [chemical binding]; other site 585396005739 substrate binding site [chemical binding]; other site 585396005740 homotetramer interface [polypeptide binding]; other site 585396005741 homodimer interface [polypeptide binding]; other site 585396005742 active site 585396005743 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 585396005744 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396005745 DNA binding site [nucleotide binding] 585396005746 domain linker motif; other site 585396005747 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 585396005748 putative dimerization interface [polypeptide binding]; other site 585396005749 putative ligand binding site [chemical binding]; other site 585396005750 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 585396005751 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 585396005752 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585396005753 active site turn [active] 585396005754 phosphorylation site [posttranslational modification] 585396005755 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 585396005756 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585396005757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396005758 homodimer interface [polypeptide binding]; other site 585396005759 catalytic residue [active] 585396005760 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 585396005761 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 585396005762 active site 585396005763 purine riboside binding site [chemical binding]; other site 585396005764 putative oxidoreductase; Provisional; Region: PRK11579 585396005765 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585396005766 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585396005767 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 585396005768 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 585396005769 electron transport complex protein RsxA; Provisional; Region: PRK05151 585396005770 electron transport complex protein RnfB; Provisional; Region: PRK05113 585396005771 Putative Fe-S cluster; Region: FeS; pfam04060 585396005772 4Fe-4S binding domain; Region: Fer4; pfam00037 585396005773 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 585396005774 SLBB domain; Region: SLBB; pfam10531 585396005775 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585396005776 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 585396005777 electron transport complex protein RnfG; Validated; Region: PRK01908 585396005778 electron transport complex RsxE subunit; Provisional; Region: PRK12405 585396005779 endonuclease III; Provisional; Region: PRK10702 585396005780 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585396005781 minor groove reading motif; other site 585396005782 helix-hairpin-helix signature motif; other site 585396005783 substrate binding pocket [chemical binding]; other site 585396005784 active site 585396005785 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 585396005786 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 585396005787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396005788 putative substrate translocation pore; other site 585396005789 POT family; Region: PTR2; pfam00854 585396005790 glutathionine S-transferase; Provisional; Region: PRK10542 585396005791 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 585396005792 C-terminal domain interface [polypeptide binding]; other site 585396005793 GSH binding site (G-site) [chemical binding]; other site 585396005794 dimer interface [polypeptide binding]; other site 585396005795 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 585396005796 N-terminal domain interface [polypeptide binding]; other site 585396005797 dimer interface [polypeptide binding]; other site 585396005798 substrate binding pocket (H-site) [chemical binding]; other site 585396005799 pyridoxamine kinase; Validated; Region: PRK05756 585396005800 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 585396005801 dimer interface [polypeptide binding]; other site 585396005802 pyridoxal binding site [chemical binding]; other site 585396005803 ATP binding site [chemical binding]; other site 585396005804 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 585396005805 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 585396005806 active site 585396005807 HIGH motif; other site 585396005808 dimer interface [polypeptide binding]; other site 585396005809 KMSKS motif; other site 585396005810 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585396005811 RNA binding surface [nucleotide binding]; other site 585396005812 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 585396005813 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 585396005814 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 585396005815 lysozyme inhibitor; Provisional; Region: PRK11372 585396005816 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 585396005817 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 585396005818 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 585396005819 transcriptional regulator SlyA; Provisional; Region: PRK03573 585396005820 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 585396005821 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 585396005822 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585396005823 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396005824 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396005825 Fusaric acid resistance protein family; Region: FUSC; pfam04632 585396005826 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585396005827 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 585396005828 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 585396005829 E-class dimer interface [polypeptide binding]; other site 585396005830 P-class dimer interface [polypeptide binding]; other site 585396005831 active site 585396005832 Cu2+ binding site [ion binding]; other site 585396005833 Zn2+ binding site [ion binding]; other site 585396005834 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585396005835 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585396005836 active site 585396005837 catalytic tetrad [active] 585396005838 Predicted Fe-S protein [General function prediction only]; Region: COG3313 585396005839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585396005840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585396005841 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 585396005842 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 585396005843 FMN binding site [chemical binding]; other site 585396005844 active site 585396005845 substrate binding site [chemical binding]; other site 585396005846 catalytic residue [active] 585396005847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585396005848 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 585396005849 dimer interface [polypeptide binding]; other site 585396005850 active site 585396005851 metal binding site [ion binding]; metal-binding site 585396005852 glutathione binding site [chemical binding]; other site 585396005853 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 585396005854 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 585396005855 dimer interface [polypeptide binding]; other site 585396005856 catalytic site [active] 585396005857 putative active site [active] 585396005858 putative substrate binding site [chemical binding]; other site 585396005859 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585396005860 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 585396005861 ATP binding site [chemical binding]; other site 585396005862 putative Mg++ binding site [ion binding]; other site 585396005863 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396005864 nucleotide binding region [chemical binding]; other site 585396005865 ATP-binding site [chemical binding]; other site 585396005866 DEAD/H associated; Region: DEAD_assoc; pfam08494 585396005867 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 585396005868 putative GSH binding site [chemical binding]; other site 585396005869 catalytic residues [active] 585396005870 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585396005871 NlpC/P60 family; Region: NLPC_P60; pfam00877 585396005872 superoxide dismutase; Provisional; Region: PRK10543 585396005873 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 585396005874 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 585396005875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396005876 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585396005877 putative substrate translocation pore; other site 585396005878 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 585396005879 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396005880 DNA binding site [nucleotide binding] 585396005881 domain linker motif; other site 585396005882 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 585396005883 dimerization interface [polypeptide binding]; other site 585396005884 ligand binding site [chemical binding]; other site 585396005885 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585396005886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396005887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585396005888 dimerization interface [polypeptide binding]; other site 585396005889 putative transporter; Provisional; Region: PRK11043 585396005890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396005891 putative substrate translocation pore; other site 585396005892 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 585396005893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 585396005894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396005895 S-adenosylmethionine binding site [chemical binding]; other site 585396005896 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 585396005897 Lumazine binding domain; Region: Lum_binding; pfam00677 585396005898 Lumazine binding domain; Region: Lum_binding; pfam00677 585396005899 multidrug efflux protein; Reviewed; Region: PRK01766 585396005900 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 585396005901 cation binding site [ion binding]; other site 585396005902 hypothetical protein; Provisional; Region: PRK09945 585396005903 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 585396005904 putative monooxygenase; Provisional; Region: PRK11118 585396005905 hypothetical protein; Provisional; Region: PRK09897 585396005906 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 585396005907 hypothetical protein; Provisional; Region: PRK09946 585396005908 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 585396005909 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 585396005910 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 585396005911 hypothetical protein; Provisional; Region: PRK09947 585396005912 putative oxidoreductase; Provisional; Region: PRK09849 585396005913 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 585396005914 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 585396005915 hypothetical protein; Provisional; Region: PRK09898 585396005916 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585396005917 hypothetical protein; Provisional; Region: PRK10292 585396005918 pyruvate kinase; Provisional; Region: PRK09206 585396005919 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 585396005920 domain interfaces; other site 585396005921 active site 585396005922 murein lipoprotein; Provisional; Region: PRK15396 585396005923 L,D-transpeptidase; Provisional; Region: PRK10190 585396005924 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585396005925 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585396005926 cysteine desufuration protein SufE; Provisional; Region: PRK09296 585396005927 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 585396005928 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 585396005929 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585396005930 catalytic residue [active] 585396005931 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 585396005932 FeS assembly protein SufD; Region: sufD; TIGR01981 585396005933 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 585396005934 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 585396005935 Walker A/P-loop; other site 585396005936 ATP binding site [chemical binding]; other site 585396005937 Q-loop/lid; other site 585396005938 ABC transporter signature motif; other site 585396005939 Walker B; other site 585396005940 D-loop; other site 585396005941 H-loop/switch region; other site 585396005942 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 585396005943 putative ABC transporter; Region: ycf24; CHL00085 585396005944 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 585396005945 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585396005946 CoenzymeA binding site [chemical binding]; other site 585396005947 subunit interaction site [polypeptide binding]; other site 585396005948 PHB binding site; other site 585396005949 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 585396005950 FAD binding domain; Region: FAD_binding_4; pfam01565 585396005951 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 585396005952 putative inner membrane protein; Provisional; Region: PRK10983 585396005953 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585396005954 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 585396005955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396005956 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585396005957 putative substrate translocation pore; other site 585396005958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396005959 putative substrate translocation pore; other site 585396005960 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 585396005961 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 585396005962 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 585396005963 shikimate binding site; other site 585396005964 NAD(P) binding site [chemical binding]; other site 585396005965 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 585396005966 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 585396005967 active site 585396005968 catalytic residue [active] 585396005969 dimer interface [polypeptide binding]; other site 585396005970 fused predicted acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit, N-terminal part 585396005971 fused predicted acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit, C-terminal part 585396005972 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 585396005973 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 585396005974 active site 585396005975 Cupin domain; Region: Cupin_2; pfam07883 585396005976 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 585396005977 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585396005978 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396005979 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 585396005980 Ligand binding site [chemical binding]; other site 585396005981 Electron transfer flavoprotein domain; Region: ETF; pfam01012 585396005982 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 585396005983 Electron transfer flavoprotein domain; Region: ETF; smart00893 585396005984 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 585396005985 oxidoreductase; Provisional; Region: PRK10015 585396005986 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 585396005987 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 585396005988 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 585396005989 acyl-activating enzyme (AAE) consensus motif; other site 585396005990 putative AMP binding site [chemical binding]; other site 585396005991 putative active site [active] 585396005992 putative CoA binding site [chemical binding]; other site 585396005993 phosphoenolpyruvate synthase; Validated; Region: PRK06464 585396005994 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 585396005995 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585396005996 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585396005997 PEP synthetase regulatory protein; Provisional; Region: PRK05339 585396005998 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 585396005999 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585396006000 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 585396006001 Uncharacterized conserved protein [Function unknown]; Region: COG0397 585396006002 hypothetical protein; Validated; Region: PRK00029 585396006003 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 585396006004 NlpC/P60 family; Region: NLPC_P60; pfam00877 585396006005 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 585396006006 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585396006007 Walker A/P-loop; other site 585396006008 ATP binding site [chemical binding]; other site 585396006009 Q-loop/lid; other site 585396006010 ABC transporter signature motif; other site 585396006011 Walker B; other site 585396006012 D-loop; other site 585396006013 H-loop/switch region; other site 585396006014 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 585396006015 catalytic residues [active] 585396006016 dimer interface [polypeptide binding]; other site 585396006017 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585396006018 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585396006019 ABC-ATPase subunit interface; other site 585396006020 dimer interface [polypeptide binding]; other site 585396006021 putative PBP binding regions; other site 585396006022 Prophage ECO111_P10, P2-like phage 585396006023 Prophage ECO111_P10; predicted integrase, N-terminal truncated 585396006024 putative transposase OrfB; Reviewed; Region: PHA02517 585396006025 HTH-like domain; Region: HTH_21; pfam13276 585396006026 Integrase core domain; Region: rve; pfam00665 585396006027 Integrase core domain; Region: rve_3; pfam13683 585396006028 Transposase; Region: HTH_Tnp_1; cl17663 585396006029 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396006030 Prophage ECO111_P10; predicted replication protein, C-terminal part 585396006031 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 585396006032 Mg binding site [ion binding]; other site 585396006033 nucleotide binding site [chemical binding]; other site 585396006034 putative protofilament interface [polypeptide binding]; other site 585396006035 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 585396006036 Phage-related protein [Function unknown]; Region: COG4695; cl01923 585396006037 Phage portal protein; Region: Phage_portal; pfam04860 585396006038 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 585396006039 terminase ATPase subunit; Provisional; Region: P; PHA02535 585396006040 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 585396006041 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 585396006042 terminase endonuclease subunit; Provisional; Region: M; PHA02537 585396006043 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 585396006044 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 585396006045 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 585396006046 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 585396006047 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 585396006048 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 585396006049 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 585396006050 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 585396006051 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 585396006052 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 585396006053 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 585396006054 Baseplate J-like protein; Region: Baseplate_J; cl01294 585396006055 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 585396006056 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 585396006057 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585396006058 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585396006059 Phage Tail Collar Domain; Region: Collar; pfam07484 585396006060 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585396006061 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 585396006062 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585396006063 trimer interface [polypeptide binding]; other site 585396006064 active site 585396006065 substrate binding site [chemical binding]; other site 585396006066 CoA binding site [chemical binding]; other site 585396006067 Phage protein U [General function prediction only]; Region: COG3499 585396006068 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 585396006069 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 585396006070 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 585396006071 Phage tail tube protein FII; Region: Phage_tube; cl01390 585396006072 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 585396006073 tail protein; Provisional; Region: D; PHA02561 585396006074 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 585396006075 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 585396006076 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585396006077 IHF dimer interface [polypeptide binding]; other site 585396006078 IHF - DNA interface [nucleotide binding]; other site 585396006079 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 585396006080 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 585396006081 putative tRNA-binding site [nucleotide binding]; other site 585396006082 B3/4 domain; Region: B3_4; pfam03483 585396006083 tRNA synthetase B5 domain; Region: B5; smart00874 585396006084 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 585396006085 dimer interface [polypeptide binding]; other site 585396006086 motif 1; other site 585396006087 motif 3; other site 585396006088 motif 2; other site 585396006089 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 585396006090 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 585396006091 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 585396006092 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 585396006093 dimer interface [polypeptide binding]; other site 585396006094 motif 1; other site 585396006095 active site 585396006096 motif 2; other site 585396006097 motif 3; other site 585396006098 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 585396006099 23S rRNA binding site [nucleotide binding]; other site 585396006100 L21 binding site [polypeptide binding]; other site 585396006101 L13 binding site [polypeptide binding]; other site 585396006102 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 585396006103 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 585396006104 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 585396006105 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 585396006106 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 585396006107 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 585396006108 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 585396006109 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 585396006110 active site 585396006111 dimer interface [polypeptide binding]; other site 585396006112 motif 1; other site 585396006113 motif 2; other site 585396006114 motif 3; other site 585396006115 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 585396006116 anticodon binding site; other site 585396006117 T3SS secreted effector-like protein EspL-homolog, N-terminal part 585396006118 T3SS secreted effector-like protein EspL-homolog, C-terminal part 585396006119 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 585396006120 6-phosphofructokinase 2; Provisional; Region: PRK10294 585396006121 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 585396006122 putative substrate binding site [chemical binding]; other site 585396006123 putative ATP binding site [chemical binding]; other site 585396006124 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 585396006125 Phosphotransferase enzyme family; Region: APH; pfam01636 585396006126 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 585396006127 active site 585396006128 ATP binding site [chemical binding]; other site 585396006129 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 585396006130 YniB-like protein; Region: YniB; pfam14002 585396006131 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 585396006132 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 585396006133 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396006134 motif II; other site 585396006135 inner membrane protein; Provisional; Region: PRK11648 585396006136 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 585396006137 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585396006138 conserved predicted protein, C-terminal part 585396006139 conserved predicted protein, N-terminal part 585396006140 cell division modulator; Provisional; Region: PRK10113 585396006141 hydroperoxidase II; Provisional; Region: katE; PRK11249 585396006142 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 585396006143 tetramer interface [polypeptide binding]; other site 585396006144 heme binding pocket [chemical binding]; other site 585396006145 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 585396006146 domain interactions; other site 585396006147 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 585396006148 putative active site [active] 585396006149 YdjC motif; other site 585396006150 Mg binding site [ion binding]; other site 585396006151 putative homodimer interface [polypeptide binding]; other site 585396006152 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 585396006153 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 585396006154 NAD binding site [chemical binding]; other site 585396006155 sugar binding site [chemical binding]; other site 585396006156 divalent metal binding site [ion binding]; other site 585396006157 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585396006158 dimer interface [polypeptide binding]; other site 585396006159 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 585396006160 Cupin domain; Region: Cupin_2; pfam07883 585396006161 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396006162 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 585396006163 methionine cluster; other site 585396006164 active site 585396006165 phosphorylation site [posttranslational modification] 585396006166 metal binding site [ion binding]; metal-binding site 585396006167 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 585396006168 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 585396006169 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 585396006170 active site 585396006171 P-loop; other site 585396006172 phosphorylation site [posttranslational modification] 585396006173 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 585396006174 NAD+ synthetase; Region: nadE; TIGR00552 585396006175 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 585396006176 homodimer interface [polypeptide binding]; other site 585396006177 NAD binding pocket [chemical binding]; other site 585396006178 ATP binding pocket [chemical binding]; other site 585396006179 Mg binding site [ion binding]; other site 585396006180 active-site loop [active] 585396006181 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 585396006182 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 585396006183 GIY-YIG motif/motif A; other site 585396006184 active site 585396006185 catalytic site [active] 585396006186 putative DNA binding site [nucleotide binding]; other site 585396006187 metal binding site [ion binding]; metal-binding site 585396006188 hypothetical protein; Provisional; Region: PRK11396 585396006189 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 585396006190 dimer interface [polypeptide binding]; other site 585396006191 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 585396006192 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 585396006193 putative active site [active] 585396006194 Zn binding site [ion binding]; other site 585396006195 succinylarginine dihydrolase; Provisional; Region: PRK13281 585396006196 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 585396006197 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 585396006198 NAD(P) binding site [chemical binding]; other site 585396006199 catalytic residues [active] 585396006200 arginine succinyltransferase; Provisional; Region: PRK10456 585396006201 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 585396006202 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 585396006203 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585396006204 inhibitor-cofactor binding pocket; inhibition site 585396006205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396006206 catalytic residue [active] 585396006207 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 585396006208 putative catalytic site [active] 585396006209 putative phosphate binding site [ion binding]; other site 585396006210 active site 585396006211 metal binding site A [ion binding]; metal-binding site 585396006212 DNA binding site [nucleotide binding] 585396006213 putative AP binding site [nucleotide binding]; other site 585396006214 putative metal binding site B [ion binding]; other site 585396006215 Uncharacterized conserved protein [Function unknown]; Region: COG0398 585396006216 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585396006217 Uncharacterized conserved protein [Function unknown]; Region: COG0398 585396006218 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585396006219 Uncharacterized conserved protein [Function unknown]; Region: COG2128 585396006220 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 585396006221 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 585396006222 hypothetical protein; Provisional; Region: PRK11622 585396006223 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 585396006224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396006225 dimer interface [polypeptide binding]; other site 585396006226 conserved gate region; other site 585396006227 putative PBP binding loops; other site 585396006228 ABC-ATPase subunit interface; other site 585396006229 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 585396006230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396006231 Walker A/P-loop; other site 585396006232 ATP binding site [chemical binding]; other site 585396006233 Q-loop/lid; other site 585396006234 ABC transporter signature motif; other site 585396006235 Walker B; other site 585396006236 D-loop; other site 585396006237 H-loop/switch region; other site 585396006238 Rhodanese Homology Domain; Region: RHOD; smart00450 585396006239 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 585396006240 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 585396006241 active site residue [active] 585396006242 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 585396006243 active site residue [active] 585396006244 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 585396006245 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 585396006246 active site 585396006247 8-oxo-dGMP binding site [chemical binding]; other site 585396006248 nudix motif; other site 585396006249 metal binding site [ion binding]; metal-binding site 585396006250 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 585396006251 glutamate dehydrogenase; Provisional; Region: PRK09414 585396006252 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 585396006253 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 585396006254 NAD(P) binding site [chemical binding]; other site 585396006255 hypothetical protein; Provisional; Region: PRK11380 585396006256 DNA topoisomerase III; Provisional; Region: PRK07726 585396006257 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 585396006258 active site 585396006259 putative interdomain interaction site [polypeptide binding]; other site 585396006260 putative metal-binding site [ion binding]; other site 585396006261 putative nucleotide binding site [chemical binding]; other site 585396006262 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 585396006263 domain I; other site 585396006264 DNA binding groove [nucleotide binding] 585396006265 phosphate binding site [ion binding]; other site 585396006266 domain II; other site 585396006267 domain III; other site 585396006268 nucleotide binding site [chemical binding]; other site 585396006269 catalytic site [active] 585396006270 domain IV; other site 585396006271 selenophosphate synthetase; Provisional; Region: PRK00943 585396006272 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 585396006273 dimerization interface [polypeptide binding]; other site 585396006274 putative ATP binding site [chemical binding]; other site 585396006275 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 585396006276 putative FMN binding site [chemical binding]; other site 585396006277 protease 4; Provisional; Region: PRK10949 585396006278 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 585396006279 tandem repeat interface [polypeptide binding]; other site 585396006280 oligomer interface [polypeptide binding]; other site 585396006281 active site residues [active] 585396006282 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 585396006283 tandem repeat interface [polypeptide binding]; other site 585396006284 oligomer interface [polypeptide binding]; other site 585396006285 active site residues [active] 585396006286 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 585396006287 active site 585396006288 homodimer interface [polypeptide binding]; other site 585396006289 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 585396006290 Isochorismatase family; Region: Isochorismatase; pfam00857 585396006291 catalytic triad [active] 585396006292 metal binding site [ion binding]; metal-binding site 585396006293 conserved cis-peptide bond; other site 585396006294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 585396006295 methionine sulfoxide reductase B; Provisional; Region: PRK00222 585396006296 SelR domain; Region: SelR; pfam01641 585396006297 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 585396006298 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585396006299 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585396006300 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 585396006301 active site 585396006302 phosphate binding residues; other site 585396006303 catalytic residues [active] 585396006304 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585396006305 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585396006306 active site 585396006307 catalytic tetrad [active] 585396006308 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 585396006309 PrkA family serine protein kinase; Provisional; Region: PRK15455 585396006310 AAA ATPase domain; Region: AAA_16; pfam13191 585396006311 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 585396006312 hypothetical protein; Provisional; Region: PRK05325 585396006313 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585396006314 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396006315 metal binding site [ion binding]; metal-binding site 585396006316 active site 585396006317 I-site; other site 585396006318 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585396006319 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396006320 metal binding site [ion binding]; metal-binding site 585396006321 active site 585396006322 I-site; other site 585396006323 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 585396006324 putative deacylase active site [active] 585396006325 Predicted membrane protein [Function unknown]; Region: COG2707 585396006326 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585396006327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396006328 cyanate transporter; Region: CynX; TIGR00896 585396006329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396006330 putative substrate translocation pore; other site 585396006331 Uncharacterized conserved protein [Function unknown]; Region: COG3189 585396006332 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 585396006333 Domain of unknown function (DUF333); Region: DUF333; pfam03891 585396006334 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 585396006335 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585396006336 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585396006337 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396006338 metal binding site [ion binding]; metal-binding site 585396006339 active site 585396006340 I-site; other site 585396006341 conserved predicted inner membrane protein, C-terminal part 585396006342 Transposase; Region: HTH_Tnp_1; cl17663 585396006343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396006344 putative transposase OrfB; Reviewed; Region: PHA02517 585396006345 HTH-like domain; Region: HTH_21; pfam13276 585396006346 Integrase core domain; Region: rve; pfam00665 585396006347 Integrase core domain; Region: rve_3; pfam13683 585396006348 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 585396006349 Probable transposase; Region: OrfB_IS605; pfam01385 585396006350 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 585396006351 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 585396006352 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 585396006353 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 585396006354 leucine export protein LeuE; Provisional; Region: PRK10958 585396006355 transcriptional activator TtdR; Provisional; Region: PRK09801 585396006356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396006357 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 585396006358 putative effector binding pocket; other site 585396006359 putative dimerization interface [polypeptide binding]; other site 585396006360 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 585396006361 tartrate dehydrogenase; Region: TTC; TIGR02089 585396006362 putative transporter; Provisional; Region: PRK09950 585396006363 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 585396006364 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 585396006365 [2Fe-2S] cluster binding site [ion binding]; other site 585396006366 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 585396006367 putative alpha subunit interface [polypeptide binding]; other site 585396006368 putative active site [active] 585396006369 putative substrate binding site [chemical binding]; other site 585396006370 Fe binding site [ion binding]; other site 585396006371 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 585396006372 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 585396006373 FMN-binding pocket [chemical binding]; other site 585396006374 flavin binding motif; other site 585396006375 phosphate binding motif [ion binding]; other site 585396006376 beta-alpha-beta structure motif; other site 585396006377 NAD binding pocket [chemical binding]; other site 585396006378 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585396006379 catalytic loop [active] 585396006380 iron binding site [ion binding]; other site 585396006381 ribonuclease D; Provisional; Region: PRK10829 585396006382 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 585396006383 catalytic site [active] 585396006384 putative active site [active] 585396006385 putative substrate binding site [chemical binding]; other site 585396006386 Helicase and RNase D C-terminal; Region: HRDC; smart00341 585396006387 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 585396006388 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 585396006389 acyl-activating enzyme (AAE) consensus motif; other site 585396006390 putative AMP binding site [chemical binding]; other site 585396006391 putative active site [active] 585396006392 putative CoA binding site [chemical binding]; other site 585396006393 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 585396006394 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 585396006395 Glycoprotease family; Region: Peptidase_M22; pfam00814 585396006396 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 585396006397 DEAD/DEAH box helicase; Region: DEAD; pfam00270 585396006398 DEAD_2; Region: DEAD_2; pfam06733 585396006399 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 585396006400 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 585396006401 homotrimer interaction site [polypeptide binding]; other site 585396006402 putative active site [active] 585396006403 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 585396006404 hypothetical protein; Provisional; Region: PRK05114 585396006405 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 585396006406 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 585396006407 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 585396006408 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 585396006409 putative active site [active] 585396006410 putative CoA binding site [chemical binding]; other site 585396006411 nudix motif; other site 585396006412 metal binding site [ion binding]; metal-binding site 585396006413 L-serine deaminase; Provisional; Region: PRK15023 585396006414 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585396006415 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585396006416 phage resistance protein; Provisional; Region: PRK10551 585396006417 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585396006418 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396006419 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585396006420 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 585396006421 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585396006422 Transporter associated domain; Region: CorC_HlyC; smart01091 585396006423 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 585396006424 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585396006425 active pocket/dimerization site; other site 585396006426 active site 585396006427 phosphorylation site [posttranslational modification] 585396006428 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585396006429 active site 585396006430 phosphorylation site [posttranslational modification] 585396006431 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 585396006432 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 585396006433 hypothetical protein; Provisional; Region: PRK02913 585396006434 hypothetical protein; Provisional; Region: PRK11469 585396006435 Domain of unknown function DUF; Region: DUF204; pfam02659 585396006436 Domain of unknown function DUF; Region: DUF204; pfam02659 585396006437 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 585396006438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396006439 S-adenosylmethionine binding site [chemical binding]; other site 585396006440 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585396006441 DNA-binding site [nucleotide binding]; DNA binding site 585396006442 RNA-binding motif; other site 585396006443 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 585396006444 YebO-like protein; Region: YebO; pfam13974 585396006445 PhoPQ regulatory protein; Provisional; Region: PRK10299 585396006446 YobH-like protein; Region: YobH; pfam13996 585396006447 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 585396006448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585396006449 dimerization interface [polypeptide binding]; other site 585396006450 putative Zn2+ binding site [ion binding]; other site 585396006451 putative DNA binding site [nucleotide binding]; other site 585396006452 Bacterial transcriptional regulator; Region: IclR; pfam01614 585396006453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396006454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585396006455 putative substrate translocation pore; other site 585396006456 heat shock protein HtpX; Provisional; Region: PRK05457 585396006457 carboxy-terminal protease; Provisional; Region: PRK11186 585396006458 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 585396006459 protein binding site [polypeptide binding]; other site 585396006460 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 585396006461 Catalytic dyad [active] 585396006462 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 585396006463 ProP expression regulator; Provisional; Region: PRK04950 585396006464 ProQ/FINO family; Region: ProQ; pfam04352 585396006465 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 585396006466 GAF domain; Region: GAF_2; pfam13185 585396006467 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 585396006468 Paraquat-inducible protein A; Region: PqiA; pfam04403 585396006469 Paraquat-inducible protein A; Region: PqiA; pfam04403 585396006470 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 585396006471 mce related protein; Region: MCE; pfam02470 585396006472 mce related protein; Region: MCE; pfam02470 585396006473 mce related protein; Region: MCE; pfam02470 585396006474 mce related protein; Region: MCE; pfam02470 585396006475 mce related protein; Region: MCE; pfam02470 585396006476 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 585396006477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396006478 S-adenosylmethionine binding site [chemical binding]; other site 585396006479 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 585396006480 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 585396006481 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585396006482 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 585396006483 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585396006484 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 585396006485 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 585396006486 hypothetical protein; Provisional; Region: PRK10301 585396006487 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 585396006488 Predicted amidohydrolase [General function prediction only]; Region: COG0388 585396006489 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 585396006490 exodeoxyribonuclease X; Provisional; Region: PRK07983 585396006491 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 585396006492 active site 585396006493 catalytic site [active] 585396006494 substrate binding site [chemical binding]; other site 585396006495 protease 2; Provisional; Region: PRK10115 585396006496 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585396006497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 585396006498 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 585396006499 putative metal binding site [ion binding]; other site 585396006500 hypothetical protein; Provisional; Region: PRK13680 585396006501 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 585396006502 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 585396006503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585396006504 ATP-grasp domain; Region: ATP-grasp; pfam02222 585396006505 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 585396006506 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 585396006507 active site 585396006508 intersubunit interface [polypeptide binding]; other site 585396006509 catalytic residue [active] 585396006510 phosphogluconate dehydratase; Validated; Region: PRK09054 585396006511 6-phosphogluconate dehydratase; Region: edd; TIGR01196 585396006512 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 585396006513 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 585396006514 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 585396006515 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 585396006516 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585396006517 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585396006518 putative active site [active] 585396006519 pyruvate kinase; Provisional; Region: PRK05826 585396006520 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 585396006521 domain interfaces; other site 585396006522 active site 585396006523 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 585396006524 Putative esterase; Region: Esterase; pfam00756 585396006525 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585396006526 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 585396006527 Amidohydrolase; Region: Amidohydro_2; pfam04909 585396006528 active site 585396006529 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 585396006530 homodimer interface [polypeptide binding]; other site 585396006531 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 585396006532 active site 585396006533 homodimer interface [polypeptide binding]; other site 585396006534 catalytic site [active] 585396006535 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 585396006536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396006537 dimer interface [polypeptide binding]; other site 585396006538 conserved gate region; other site 585396006539 putative PBP binding loops; other site 585396006540 ABC-ATPase subunit interface; other site 585396006541 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 585396006542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396006543 dimer interface [polypeptide binding]; other site 585396006544 conserved gate region; other site 585396006545 putative PBP binding loops; other site 585396006546 ABC-ATPase subunit interface; other site 585396006547 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 585396006548 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 585396006549 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 585396006550 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 585396006551 trimer interface [polypeptide binding]; other site 585396006552 active site 585396006553 UDP-GlcNAc binding site [chemical binding]; other site 585396006554 lipid binding site [chemical binding]; lipid-binding site 585396006555 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 585396006556 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585396006557 Walker A/P-loop; other site 585396006558 ATP binding site [chemical binding]; other site 585396006559 Q-loop/lid; other site 585396006560 ABC transporter signature motif; other site 585396006561 Walker B; other site 585396006562 D-loop; other site 585396006563 H-loop/switch region; other site 585396006564 TOBE domain; Region: TOBE; pfam03459 585396006565 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 585396006566 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 585396006567 C-terminal domain interface [polypeptide binding]; other site 585396006568 sugar binding site [chemical binding]; other site 585396006569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 585396006570 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 585396006571 active site 585396006572 catalytic site [active] 585396006573 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 585396006574 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 585396006575 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585396006576 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585396006577 putative acyl-acceptor binding pocket; other site 585396006578 putative peptidase; Provisional; Region: PRK11649 585396006579 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 585396006580 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585396006581 Peptidase family M23; Region: Peptidase_M23; pfam01551 585396006582 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 585396006583 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 585396006584 metal binding site [ion binding]; metal-binding site 585396006585 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 585396006586 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 585396006587 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 585396006588 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585396006589 ABC-ATPase subunit interface; other site 585396006590 dimer interface [polypeptide binding]; other site 585396006591 putative PBP binding regions; other site 585396006592 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 585396006593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396006594 Walker A motif; other site 585396006595 ATP binding site [chemical binding]; other site 585396006596 Walker B motif; other site 585396006597 arginine finger; other site 585396006598 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 585396006599 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 585396006600 RuvA N terminal domain; Region: RuvA_N; pfam01330 585396006601 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 585396006602 hypothetical protein; Provisional; Region: PRK11470 585396006603 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 585396006604 active site 585396006605 putative DNA-binding cleft [nucleotide binding]; other site 585396006606 dimer interface [polypeptide binding]; other site 585396006607 hypothetical protein; Validated; Region: PRK00110 585396006608 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 585396006609 nudix motif; other site 585396006610 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 585396006611 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 585396006612 dimer interface [polypeptide binding]; other site 585396006613 anticodon binding site; other site 585396006614 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 585396006615 homodimer interface [polypeptide binding]; other site 585396006616 motif 1; other site 585396006617 active site 585396006618 motif 2; other site 585396006619 GAD domain; Region: GAD; pfam02938 585396006620 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 585396006621 motif 3; other site 585396006622 Isochorismatase family; Region: Isochorismatase; pfam00857 585396006623 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 585396006624 catalytic triad [active] 585396006625 conserved cis-peptide bond; other site 585396006626 Prophage ECO111_P11, lambda-like phage 585396006627 DinI-like family; Region: DinI; pfam06183 585396006628 NFkB-p65-degrading zinc protease; Region: Peptidase_M85; pfam13678 585396006629 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396006630 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585396006631 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585396006632 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396006633 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585396006634 Phage-related protein, tail component [Function unknown]; Region: COG4733 585396006635 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585396006636 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585396006637 Fibronectin type III protein; Region: DUF3672; pfam12421 585396006638 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 585396006639 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 585396006640 E-class dimer interface [polypeptide binding]; other site 585396006641 P-class dimer interface [polypeptide binding]; other site 585396006642 active site 585396006643 Cu2+ binding site [ion binding]; other site 585396006644 Zn2+ binding site [ion binding]; other site 585396006645 Phage-related protein, tail component [Function unknown]; Region: COG4723 585396006646 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585396006647 MPN+ (JAMM) motif; other site 585396006648 Zinc-binding site [ion binding]; other site 585396006649 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585396006650 NlpC/P60 family; Region: NLPC_P60; cl17555 585396006651 Phage-related protein [Function unknown]; Region: gp18; COG4672 585396006652 Phage-related protein [Function unknown]; Region: COG4718 585396006653 Phage-related minor tail protein [Function unknown]; Region: COG5281 585396006654 tape measure domain; Region: tape_meas_nterm; TIGR02675 585396006655 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 585396006656 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585396006657 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 585396006658 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 585396006659 Immunoglobulin I-set domain; Region: I-set; pfam07679 585396006660 Immunoglobulin domain; Region: Ig_2; pfam13895 585396006661 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 585396006662 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 585396006663 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 585396006664 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 585396006665 Phage-related protein [Function unknown]; Region: COG4695 585396006666 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 585396006667 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 585396006668 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 585396006669 Phage capsid family; Region: Phage_capsid; pfam05065 585396006670 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 585396006671 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 585396006672 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 585396006673 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585396006674 active site 585396006675 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 585396006676 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585396006677 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585396006678 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 585396006679 ORF11CD3 domain; Region: ORF11CD3; pfam10549 585396006680 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585396006681 catalytic residues [active] 585396006682 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 585396006683 Lysis protein S; Region: Lysis_S; pfam04971 585396006684 Protein of unknown function (DUF826); Region: DUF826; pfam05696 585396006685 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 585396006686 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585396006687 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585396006688 anti-adapter protein IraM; Provisional; Region: PRK09919 585396006689 Shiga-like toxin beta subunit; Region: SLT_beta; pfam02258 585396006690 Ribosome inactivating protein; Region: RIP; pfam00161 585396006691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396006692 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585396006693 DNA methylase; Region: N6_N4_Mtase; pfam01555 585396006694 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585396006695 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585396006696 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585396006697 replicative DNA helicase; Region: DnaB; TIGR00665 585396006698 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 585396006699 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 585396006700 Walker A motif; other site 585396006701 ATP binding site [chemical binding]; other site 585396006702 Walker B motif; other site 585396006703 DNA binding loops [nucleotide binding] 585396006704 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 585396006705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396006706 Walker A motif; other site 585396006707 ATP binding site [chemical binding]; other site 585396006708 Walker B motif; other site 585396006709 arginine finger; other site 585396006710 Ash protein family; Region: Phage_ASH; pfam10554 585396006711 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585396006712 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585396006713 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 585396006714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396006715 non-specific DNA binding site [nucleotide binding]; other site 585396006716 Predicted transcriptional regulator [Transcription]; Region: COG2932 585396006717 salt bridge; other site 585396006718 sequence-specific DNA binding site [nucleotide binding]; other site 585396006719 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585396006720 Catalytic site [active] 585396006721 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396006722 non-specific DNA binding site [nucleotide binding]; other site 585396006723 salt bridge; other site 585396006724 sequence-specific DNA binding site [nucleotide binding]; other site 585396006725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396006726 non-specific DNA binding site [nucleotide binding]; other site 585396006727 salt bridge; other site 585396006728 sequence-specific DNA binding site [nucleotide binding]; other site 585396006729 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 585396006730 SPFH domain / Band 7 family; Region: Band_7; pfam01145 585396006731 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 585396006732 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 585396006733 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 585396006734 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585396006735 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 585396006736 Int/Topo IB signature motif; other site 585396006737 conserved predicted protein 585396006738 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 585396006739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396006740 S-adenosylmethionine binding site [chemical binding]; other site 585396006741 Methyltransferase domain; Region: Methyltransf_23; pfam13489 585396006742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396006743 S-adenosylmethionine binding site [chemical binding]; other site 585396006744 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585396006745 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585396006746 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 585396006747 molybdopterin cofactor binding site [chemical binding]; other site 585396006748 substrate binding site [chemical binding]; other site 585396006749 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585396006750 molybdopterin cofactor binding site; other site 585396006751 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 585396006752 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 585396006753 copper homeostasis protein CutC; Provisional; Region: PRK11572 585396006754 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 585396006755 putative metal binding site [ion binding]; other site 585396006756 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 585396006757 arginyl-tRNA synthetase; Region: argS; TIGR00456 585396006758 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 585396006759 active site 585396006760 HIGH motif; other site 585396006761 KMSK motif region; other site 585396006762 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 585396006763 tRNA binding surface [nucleotide binding]; other site 585396006764 anticodon binding site; other site 585396006765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 585396006766 Flagellar protein FlhE; Region: FlhE; pfam06366 585396006767 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 585396006768 FHIPEP family; Region: FHIPEP; pfam00771 585396006769 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 585396006770 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 585396006771 chemotaxis regulator CheZ; Provisional; Region: PRK11166 585396006772 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 585396006773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396006774 active site 585396006775 phosphorylation site [posttranslational modification] 585396006776 intermolecular recognition site; other site 585396006777 dimerization interface [polypeptide binding]; other site 585396006778 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 585396006779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396006780 active site 585396006781 phosphorylation site [posttranslational modification] 585396006782 intermolecular recognition site; other site 585396006783 dimerization interface [polypeptide binding]; other site 585396006784 CheB methylesterase; Region: CheB_methylest; pfam01339 585396006785 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 585396006786 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 585396006787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396006788 S-adenosylmethionine binding site [chemical binding]; other site 585396006789 methyl-accepting protein IV; Provisional; Region: PRK09793 585396006790 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585396006791 dimer interface [polypeptide binding]; other site 585396006792 ligand binding site [chemical binding]; other site 585396006793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585396006794 dimerization interface [polypeptide binding]; other site 585396006795 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585396006796 dimer interface [polypeptide binding]; other site 585396006797 putative CheW interface [polypeptide binding]; other site 585396006798 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 585396006799 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585396006800 dimer interface [polypeptide binding]; other site 585396006801 ligand binding site [chemical binding]; other site 585396006802 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585396006803 dimerization interface [polypeptide binding]; other site 585396006804 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585396006805 dimer interface [polypeptide binding]; other site 585396006806 putative CheW interface [polypeptide binding]; other site 585396006807 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 585396006808 putative CheA interaction surface; other site 585396006809 chemotaxis protein CheA; Provisional; Region: PRK10547 585396006810 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585396006811 putative binding surface; other site 585396006812 active site 585396006813 CheY binding; Region: CheY-binding; pfam09078 585396006814 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 585396006815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396006816 ATP binding site [chemical binding]; other site 585396006817 Mg2+ binding site [ion binding]; other site 585396006818 G-X-G motif; other site 585396006819 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 585396006820 flagellar motor protein MotB; Validated; Region: motB; PRK09041 585396006821 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 585396006822 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585396006823 ligand binding site [chemical binding]; other site 585396006824 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 585396006825 flagellar motor protein MotA; Validated; Region: PRK09110 585396006826 transcriptional activator FlhC; Provisional; Region: PRK12722 585396006827 transcriptional activator FlhD; Provisional; Region: PRK02909 585396006828 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585396006829 Ligand Binding Site [chemical binding]; other site 585396006830 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 585396006831 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 585396006832 active site 585396006833 homotetramer interface [polypeptide binding]; other site 585396006834 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 585396006835 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 585396006836 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585396006837 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585396006838 TM-ABC transporter signature motif; other site 585396006839 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 585396006840 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585396006841 Walker A/P-loop; other site 585396006842 ATP binding site [chemical binding]; other site 585396006843 Q-loop/lid; other site 585396006844 ABC transporter signature motif; other site 585396006845 Walker B; other site 585396006846 D-loop; other site 585396006847 H-loop/switch region; other site 585396006848 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585396006849 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 585396006850 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 585396006851 ligand binding site [chemical binding]; other site 585396006852 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 585396006853 Ferritin-like domain; Region: Ferritin; pfam00210 585396006854 ferroxidase diiron center [ion binding]; other site 585396006855 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 585396006856 YecR-like lipoprotein; Region: YecR; pfam13992 585396006857 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 585396006858 Ferritin-like domain; Region: Ferritin; pfam00210 585396006859 ferroxidase diiron center [ion binding]; other site 585396006860 probable metal-binding protein; Region: matur_matur; TIGR03853 585396006861 tyrosine transporter TyrP; Provisional; Region: PRK15132 585396006862 aromatic amino acid transport protein; Region: araaP; TIGR00837 585396006863 hypothetical protein; Provisional; Region: PRK10396 585396006864 yecA family protein; Region: ygfB_yecA; TIGR02292 585396006865 SEC-C motif; Region: SEC-C; pfam02810 585396006866 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 585396006867 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 585396006868 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 585396006869 GIY-YIG motif/motif A; other site 585396006870 active site 585396006871 catalytic site [active] 585396006872 putative DNA binding site [nucleotide binding]; other site 585396006873 metal binding site [ion binding]; metal-binding site 585396006874 UvrB/uvrC motif; Region: UVR; pfam02151 585396006875 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 585396006876 Helix-hairpin-helix motif; Region: HHH; pfam00633 585396006877 response regulator; Provisional; Region: PRK09483 585396006878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396006879 active site 585396006880 phosphorylation site [posttranslational modification] 585396006881 intermolecular recognition site; other site 585396006882 dimerization interface [polypeptide binding]; other site 585396006883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396006884 DNA binding residues [nucleotide binding] 585396006885 dimerization interface [polypeptide binding]; other site 585396006886 hypothetical protein; Provisional; Region: PRK10613 585396006887 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 585396006888 Autoinducer binding domain; Region: Autoind_bind; pfam03472 585396006889 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396006890 DNA binding residues [nucleotide binding] 585396006891 dimerization interface [polypeptide binding]; other site 585396006892 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 585396006893 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585396006894 Walker A/P-loop; other site 585396006895 ATP binding site [chemical binding]; other site 585396006896 Q-loop/lid; other site 585396006897 ABC transporter signature motif; other site 585396006898 Walker B; other site 585396006899 D-loop; other site 585396006900 H-loop/switch region; other site 585396006901 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585396006902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396006903 dimer interface [polypeptide binding]; other site 585396006904 conserved gate region; other site 585396006905 putative PBP binding loops; other site 585396006906 ABC-ATPase subunit interface; other site 585396006907 D-cysteine desulfhydrase; Validated; Region: PRK03910 585396006908 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 585396006909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396006910 catalytic residue [active] 585396006911 cystine transporter subunit; Provisional; Region: PRK11260 585396006912 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396006913 substrate binding pocket [chemical binding]; other site 585396006914 membrane-bound complex binding site; other site 585396006915 hinge residues; other site 585396006916 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 585396006917 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 585396006918 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585396006919 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585396006920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585396006921 DNA binding residues [nucleotide binding] 585396006922 flagellin; Validated; Region: PRK08026 585396006923 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 585396006924 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 585396006925 flagellar capping protein; Reviewed; Region: fliD; PRK08032 585396006926 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 585396006927 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 585396006928 Transposase; Region: HTH_Tnp_1; cl17663 585396006929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396006930 putative transposase OrfB; Reviewed; Region: PHA02517 585396006931 HTH-like domain; Region: HTH_21; pfam13276 585396006932 Integrase core domain; Region: rve; pfam00665 585396006933 Integrase core domain; Region: rve_3; pfam13683 585396006934 Flagellar protein FliS; Region: FliS; cl00654 585396006935 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 585396006936 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 585396006937 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 585396006938 active site 585396006939 Na/Ca binding site [ion binding]; other site 585396006940 catalytic site [active] 585396006941 lipoprotein; Provisional; Region: PRK10397 585396006942 putative inner membrane protein; Provisional; Region: PRK11099 585396006943 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 585396006944 CPxP motif; other site 585396006945 hypothetical protein; Provisional; Region: PRK09951 585396006946 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 585396006947 Probable transposase; Region: OrfB_IS605; pfam01385 585396006948 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 585396006949 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 585396006950 putative transposase TnpA of insertion sequence IS609, N-terminal fragment 585396006951 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585396006952 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 585396006953 substrate binding site [chemical binding]; other site 585396006954 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 585396006955 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 585396006956 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 585396006957 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 585396006958 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 585396006959 flagellar motor switch protein FliG; Region: fliG; TIGR00207 585396006960 FliG C-terminal domain; Region: FliG_C; pfam01706 585396006961 flagellar assembly protein H; Validated; Region: fliH; PRK05687 585396006962 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 585396006963 Flagellar assembly protein FliH; Region: FliH; pfam02108 585396006964 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 585396006965 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 585396006966 Walker A motif/ATP binding site; other site 585396006967 Walker B motif; other site 585396006968 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 585396006969 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 585396006970 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 585396006971 flagellar hook-length control protein; Provisional; Region: PRK10118 585396006972 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 585396006973 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 585396006974 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 585396006975 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 585396006976 flagellar motor switch protein; Validated; Region: fliN; PRK05698 585396006977 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 585396006978 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 585396006979 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 585396006980 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 585396006981 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 585396006982 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396006983 DNA binding residues [nucleotide binding] 585396006984 dimerization interface [polypeptide binding]; other site 585396006985 hypothetical protein; Provisional; Region: PRK10708 585396006986 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 585396006987 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 585396006988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396006989 active site 585396006990 motif I; other site 585396006991 motif II; other site 585396006992 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 585396006993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396006994 metal binding site [ion binding]; metal-binding site 585396006995 active site 585396006996 I-site; other site 585396006997 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 585396006998 hypothetical protein; Provisional; Region: PRK10062 585396006999 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 585396007000 EamA-like transporter family; Region: EamA; pfam00892 585396007001 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 585396007002 additional DNA contacts [nucleotide binding]; other site 585396007003 mismatch recognition site; other site 585396007004 active site 585396007005 zinc binding site [ion binding]; other site 585396007006 DNA intercalation site [nucleotide binding]; other site 585396007007 DNA cytosine methylase; Provisional; Region: PRK10458 585396007008 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 585396007009 cofactor binding site; other site 585396007010 DNA binding site [nucleotide binding] 585396007011 substrate interaction site [chemical binding]; other site 585396007012 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 585396007013 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585396007014 Zn2+ binding site [ion binding]; other site 585396007015 Mg2+ binding site [ion binding]; other site 585396007016 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 585396007017 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585396007018 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585396007019 trimer interface [polypeptide binding]; other site 585396007020 eyelet of channel; other site 585396007021 chaperone protein HchA; Provisional; Region: PRK04155 585396007022 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 585396007023 dimer interface [polypeptide binding]; other site 585396007024 metal binding site [ion binding]; metal-binding site 585396007025 potential oxyanion hole; other site 585396007026 potential catalytic triad [active] 585396007027 conserved cys residue [active] 585396007028 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 585396007029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396007030 dimer interface [polypeptide binding]; other site 585396007031 phosphorylation site [posttranslational modification] 585396007032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396007033 ATP binding site [chemical binding]; other site 585396007034 Mg2+ binding site [ion binding]; other site 585396007035 G-X-G motif; other site 585396007036 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 585396007037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396007038 active site 585396007039 phosphorylation site [posttranslational modification] 585396007040 intermolecular recognition site; other site 585396007041 dimerization interface [polypeptide binding]; other site 585396007042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396007043 DNA binding site [nucleotide binding] 585396007044 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 585396007045 active site 585396007046 homotetramer interface [polypeptide binding]; other site 585396007047 TMAO/DMSO reductase; Reviewed; Region: PRK05363 585396007048 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 585396007049 Moco binding site; other site 585396007050 metal coordination site [ion binding]; other site 585396007051 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 585396007052 zinc/cadmium-binding protein; Provisional; Region: PRK10306 585396007053 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 585396007054 Prophage ECO111_P12, lambda-like phage 585396007055 NFkB-p65-degrading zinc protease; Region: Peptidase_M85; pfam13678 585396007056 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396007057 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585396007058 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585396007059 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396007060 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585396007061 Phage-related protein, tail component [Function unknown]; Region: COG4733 585396007062 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585396007063 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585396007064 Interdomain contacts; other site 585396007065 Cytokine receptor motif; other site 585396007066 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585396007067 Fibronectin type III protein; Region: DUF3672; pfam12421 585396007068 Phage-related protein, tail component [Function unknown]; Region: COG4723 585396007069 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585396007070 MPN+ (JAMM) motif; other site 585396007071 Zinc-binding site [ion binding]; other site 585396007072 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585396007073 NlpC/P60 family; Region: NLPC_P60; cl17555 585396007074 Phage-related protein [Function unknown]; Region: gp18; COG4672 585396007075 Phage-related protein [Function unknown]; Region: COG4718 585396007076 Phage-related minor tail protein [Function unknown]; Region: COG5281 585396007077 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585396007078 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585396007079 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585396007080 Minor tail protein T; Region: Phage_tail_T; cl05636 585396007081 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 585396007082 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585396007083 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585396007084 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585396007085 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585396007086 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 585396007087 DNA packaging protein FI; Region: Packaging_FI; pfam14000 585396007088 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585396007089 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585396007090 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 585396007091 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 585396007092 tandem repeat interface [polypeptide binding]; other site 585396007093 oligomer interface [polypeptide binding]; other site 585396007094 active site residues [active] 585396007095 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585396007096 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585396007097 gpW; Region: gpW; pfam02831 585396007098 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585396007099 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 585396007100 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 585396007101 PerC transcriptional activator; Region: PerC; pfam06069 585396007102 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585396007103 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585396007104 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585396007105 catalytic residues [active] 585396007106 Prophage ECO111_P12; conserved predicted protein, C-terminal part 585396007107 Prophage ECO111_P12; conserved predicted protein, N-terminal part 585396007108 Lysis protein S; Region: Lysis_S; pfam04971 585396007109 Protein of unknown function (DUF826); Region: DUF826; pfam05696 585396007110 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585396007111 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585396007112 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 585396007113 tellurite resistance protein terB; Region: terB; cd07176 585396007114 putative metal binding site [ion binding]; other site 585396007115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396007116 Transposase; Region: HTH_Tnp_1; pfam01527 585396007117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585396007118 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585396007119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585396007120 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585396007121 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585396007122 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585396007123 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585396007124 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396007125 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 585396007126 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585396007127 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585396007128 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 585396007129 Hok/gef family; Region: HOK_GEF; pfam01848 585396007130 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585396007131 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 585396007132 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1710 585396007133 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 585396007134 putative replication protein; Provisional; Region: PRK12377 585396007135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396007136 Walker A motif; other site 585396007137 ATP binding site [chemical binding]; other site 585396007138 Walker B motif; other site 585396007139 arginine finger; other site 585396007140 primosomal protein DnaI; Provisional; Region: PRK02854 585396007141 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585396007142 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 585396007143 transcriptional repressor DicA; Reviewed; Region: PRK09706 585396007144 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 585396007145 DicB protein; Region: DicB; pfam05358 585396007146 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585396007147 predicted exonuclease, N-terminal fragment 585396007148 putative transposase OrfB; Reviewed; Region: PHA02517 585396007149 HTH-like domain; Region: HTH_21; pfam13276 585396007150 Integrase core domain; Region: rve; pfam00665 585396007151 Integrase core domain; Region: rve_3; pfam13683 585396007152 Transposase; Region: HTH_Tnp_1; cl17663 585396007153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396007154 Prophage ECO111_P12; predicted exonuclease, C-terminal part 585396007155 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 585396007156 Integrative element ECO111_IE03 585396007157 integrase; Provisional; Region: PRK09692 585396007158 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585396007159 active site 585396007160 Int/Topo IB signature motif; other site 585396007161 putative transposase OrfB; Reviewed; Region: PHA02517 585396007162 HTH-like domain; Region: HTH_21; pfam13276 585396007163 Integrase core domain; Region: rve; pfam00665 585396007164 Integrase core domain; Region: rve_3; pfam13683 585396007165 Transposase; Region: HTH_Tnp_1; cl17663 585396007166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396007167 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585396007168 predicted shikimate transporter, N-terminal part 585396007169 predicted shikimate transporter, C-terminal part 585396007170 AMP nucleosidase; Provisional; Region: PRK08292 585396007171 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 585396007172 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 585396007173 hypothetical protein; Provisional; Region: PRK12378 585396007174 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 585396007175 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 585396007176 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 585396007177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396007178 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 585396007179 putative substrate binding site [chemical binding]; other site 585396007180 dimerization interface [polypeptide binding]; other site 585396007181 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 585396007182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396007183 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 585396007184 putative dimerization interface [polypeptide binding]; other site 585396007185 L,D-transpeptidase; Provisional; Region: PRK10190 585396007186 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585396007187 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 585396007188 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 585396007189 putative dimer interface [polypeptide binding]; other site 585396007190 active site pocket [active] 585396007191 putative cataytic base [active] 585396007192 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 585396007193 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 585396007194 homotrimer interface [polypeptide binding]; other site 585396007195 Walker A motif; other site 585396007196 GTP binding site [chemical binding]; other site 585396007197 Walker B motif; other site 585396007198 Transposase; Region: HTH_Tnp_1; cl17663 585396007199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396007200 putative transposase OrfB; Reviewed; Region: PHA02517 585396007201 HTH-like domain; Region: HTH_21; pfam13276 585396007202 Integrase core domain; Region: rve; pfam00665 585396007203 Integrase core domain; Region: rve_3; pfam13683 585396007204 conserved predicted protein, C-terminal part 585396007205 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585396007206 Antirestriction protein; Region: Antirestrict; pfam03230 585396007207 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585396007208 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585396007209 MPN+ (JAMM) motif; other site 585396007210 Zinc-binding site [ion binding]; other site 585396007211 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585396007212 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585396007213 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 585396007214 conserved predicted protein (pseudogene by IS insertion) 585396007215 hypothetical protein; Provisional; Region: PRK05423 585396007216 conserved predicted inner membrane protein, C-terminal part 585396007217 DNA gyrase inhibitor; Provisional; Region: PRK10016 585396007218 putative transposase OrfB; Reviewed; Region: PHA02517 585396007219 HTH-like domain; Region: HTH_21; pfam13276 585396007220 Integrase core domain; Region: rve; pfam00665 585396007221 Integrase core domain; Region: rve_3; pfam13683 585396007222 Transposase; Region: HTH_Tnp_1; cl17663 585396007223 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396007224 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 585396007225 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585396007226 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 585396007227 Prophage ECO111_P13, lambda-like phage 585396007228 Prophage ECO111_P13; acyltransferase family protein, N-terminal part 585396007229 Prophage ECO111_P13; acyltransferase family protein, C-terminal part 585396007230 Head binding; Region: Head_binding; pfam09008 585396007231 Right handed beta helix region; Region: Beta_helix; pfam13229 585396007232 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 585396007233 Phage anti-repressor protein [Transcription]; Region: COG3561 585396007234 Arc-like DNA binding domain; Region: Arc; pfam03869 585396007235 Mnt; Region: mnt; PHA01513 585396007236 Arc-like DNA binding domain; Region: Arc; pfam03869 585396007237 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 585396007238 PEGA domain; Region: PEGA; pfam08308 585396007239 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 585396007240 NUMOD4 motif; Region: NUMOD4; pfam07463 585396007241 HNH endonuclease; Region: HNH_3; pfam13392 585396007242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 585396007243 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 585396007244 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 585396007245 putative transposase OrfB; Reviewed; Region: PHA02517 585396007246 HTH-like domain; Region: HTH_21; pfam13276 585396007247 Integrase core domain; Region: rve; pfam00665 585396007248 Integrase core domain; Region: rve_3; pfam13683 585396007249 Transposase; Region: HTH_Tnp_1; cl17663 585396007250 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396007251 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 585396007252 Prophage ECO111_P13; predicted phage scaffold protein, C-terminal fragment 585396007253 Transposase; Region: HTH_Tnp_1; cl17663 585396007254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396007255 putative transposase OrfB; Reviewed; Region: PHA02517 585396007256 HTH-like domain; Region: HTH_21; pfam13276 585396007257 Integrase core domain; Region: rve; pfam00665 585396007258 Integrase core domain; Region: rve_3; pfam13683 585396007259 Prophage ECO111_P13; predicted phage scaffold protein, N-terminal fragment 585396007260 Phage terminase large subunit; Region: Terminase_3; pfam04466 585396007261 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 585396007262 hypothetical protein; Region: PHA00781 585396007263 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 585396007264 hypothetical protein; Region: PHA01971 585396007265 Prophage ECO111_P13; conserved predicted protein, C-terminal part 585396007266 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585396007267 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585396007268 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 585396007269 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585396007270 catalytic residue [active] 585396007271 phage holin, lambda family; Region: holin_lambda; TIGR01594 585396007272 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585396007273 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 585396007274 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585396007275 active site 585396007276 metal binding site [ion binding]; metal-binding site 585396007277 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 585396007278 HNH endonuclease; Region: HNH_3; pfam13392 585396007279 AP2 domain; Region: AP2; pfam00847 585396007280 NinF protein; Region: NinF; pfam05810 585396007281 NINE Protein; Region: NinE; pfam05322 585396007282 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 585396007283 NinB protein; Region: NinB; pfam05772 585396007284 restriction alleviation protein, Lar family; Region: anti_R_Lar; TIGR03655 585396007285 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 585396007286 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 585396007287 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 585396007288 Walker A motif; other site 585396007289 ATP binding site [chemical binding]; other site 585396007290 Walker B motif; other site 585396007291 Protein of unknown function (DUF2740); Region: DUF2740; pfam10872 585396007292 Bacteriophage CII protein; Region: Phage_CII; pfam05269 585396007293 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396007294 non-specific DNA binding site [nucleotide binding]; other site 585396007295 salt bridge; other site 585396007296 sequence-specific DNA binding site [nucleotide binding]; other site 585396007297 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585396007298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396007299 salt bridge; other site 585396007300 non-specific DNA binding site [nucleotide binding]; other site 585396007301 sequence-specific DNA binding site [nucleotide binding]; other site 585396007302 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585396007303 Catalytic site [active] 585396007304 Antirestriction protein Ral; Region: Ral; pfam11058 585396007305 ERF superfamily; Region: ERF; pfam04404 585396007306 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 585396007307 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 585396007308 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585396007309 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 585396007310 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 585396007311 integrase; Provisional; Region: PRK09692 585396007312 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585396007313 active site 585396007314 Int/Topo IB signature motif; other site 585396007315 exonuclease I; Provisional; Region: sbcB; PRK11779 585396007316 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 585396007317 active site 585396007318 catalytic site [active] 585396007319 substrate binding site [chemical binding]; other site 585396007320 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 585396007321 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 585396007322 CPxP motif; other site 585396007323 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 585396007324 Sulphur transport; Region: Sulf_transp; pfam04143 585396007325 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 585396007326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396007327 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585396007328 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585396007329 dimerization interface [polypeptide binding]; other site 585396007330 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585396007331 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 585396007332 putative NAD(P) binding site [chemical binding]; other site 585396007333 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 585396007334 antitoxin YefM; Provisional; Region: PRK11409 585396007335 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 585396007336 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 585396007337 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 585396007338 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 585396007339 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 585396007340 NAD binding site [chemical binding]; other site 585396007341 dimerization interface [polypeptide binding]; other site 585396007342 product binding site; other site 585396007343 substrate binding site [chemical binding]; other site 585396007344 zinc binding site [ion binding]; other site 585396007345 catalytic residues [active] 585396007346 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 585396007347 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585396007348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396007349 homodimer interface [polypeptide binding]; other site 585396007350 catalytic residue [active] 585396007351 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 585396007352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396007353 active site 585396007354 motif I; other site 585396007355 motif II; other site 585396007356 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 585396007357 putative active site pocket [active] 585396007358 4-fold oligomerization interface [polypeptide binding]; other site 585396007359 metal binding residues [ion binding]; metal-binding site 585396007360 3-fold/trimer interface [polypeptide binding]; other site 585396007361 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 585396007362 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 585396007363 putative active site [active] 585396007364 oxyanion strand; other site 585396007365 catalytic triad [active] 585396007366 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 585396007367 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 585396007368 catalytic residues [active] 585396007369 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 585396007370 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 585396007371 substrate binding site [chemical binding]; other site 585396007372 glutamase interaction surface [polypeptide binding]; other site 585396007373 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 585396007374 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 585396007375 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 585396007376 metal binding site [ion binding]; metal-binding site 585396007377 chain length determinant protein WzzB; Provisional; Region: PRK15471 585396007378 Chain length determinant protein; Region: Wzz; pfam02706 585396007379 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585396007380 Nucleoside-diphosphate-sugar epimerases, N-terminal part 585396007381 Nucleoside-diphosphate-sugar epimerases, N-terminal part 585396007382 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 585396007383 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 585396007384 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 585396007385 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 585396007386 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585396007387 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 585396007388 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 585396007389 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585396007390 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 585396007391 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 585396007392 metal-binding site 585396007393 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 585396007394 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 585396007395 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 585396007396 inhibitor-cofactor binding pocket; inhibition site 585396007397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396007398 catalytic residue [active] 585396007399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585396007400 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 585396007401 NAD(P) binding site [chemical binding]; other site 585396007402 active site 585396007403 phosphomannomutase CpsG; Provisional; Region: PRK15414 585396007404 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 585396007405 active site 585396007406 substrate binding site [chemical binding]; other site 585396007407 metal binding site [ion binding]; metal-binding site 585396007408 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 585396007409 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 585396007410 Substrate binding site; other site 585396007411 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 585396007412 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 585396007413 active site 585396007414 GDP-Mannose binding site [chemical binding]; other site 585396007415 dimer interface [polypeptide binding]; other site 585396007416 modified nudix motif 585396007417 metal binding site [ion binding]; metal-binding site 585396007418 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 585396007419 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 585396007420 NADP-binding site; other site 585396007421 homotetramer interface [polypeptide binding]; other site 585396007422 substrate binding site [chemical binding]; other site 585396007423 homodimer interface [polypeptide binding]; other site 585396007424 active site 585396007425 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 585396007426 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585396007427 putative ADP-binding pocket [chemical binding]; other site 585396007428 GalU regulator GalF; Provisional; Region: PRK10122 585396007429 active site 585396007430 IS2 transposase TnpB; Reviewed; Region: PRK09409 585396007431 HTH-like domain; Region: HTH_21; pfam13276 585396007432 Integrase core domain; Region: rve; pfam00665 585396007433 Integrase core domain; Region: rve_3; pfam13683 585396007434 IS2 repressor TnpA; Reviewed; Region: PRK09413 585396007435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396007436 putative transposase of insertion sequence IS30, N-terminal fragment 585396007437 putative transposase OrfA of insertion sequence IS911, N-terminal fragment 585396007438 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 585396007439 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 585396007440 NADP-binding site; other site 585396007441 homotetramer interface [polypeptide binding]; other site 585396007442 homodimer interface [polypeptide binding]; other site 585396007443 active site 585396007444 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 585396007445 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 585396007446 putative trimer interface [polypeptide binding]; other site 585396007447 putative active site [active] 585396007448 putative substrate binding site [chemical binding]; other site 585396007449 putative CoA binding site [chemical binding]; other site 585396007450 putative glycosyl transferase; Provisional; Region: PRK10063 585396007451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 585396007452 active site 585396007453 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 585396007454 predicted glycosyl transferase WcaC, C-terminal part 585396007455 predicted glycosyl transferase WcaC, N-terminal part 585396007456 putative acyl transferase; Provisional; Region: PRK10191 585396007457 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585396007458 trimer interface [polypeptide binding]; other site 585396007459 active site 585396007460 substrate binding site [chemical binding]; other site 585396007461 CoA binding site [chemical binding]; other site 585396007462 putative glycosyl transferase; Provisional; Region: PRK10018 585396007463 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 585396007464 active site 585396007465 tyrosine kinase; Provisional; Region: PRK11519 585396007466 Chain length determinant protein; Region: Wzz; pfam02706 585396007467 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585396007468 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585396007469 Low molecular weight phosphatase family; Region: LMWPc; cd00115 585396007470 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 585396007471 active site 585396007472 lipoprotein Wza required for capsular polysaccharide translocation through the outer membrane, C-terminal part 585396007473 lipoprotein Wza required for capsular polysaccharide translocation through the outer membrane, N-terminal part 585396007474 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585396007475 FOG: CBS domain [General function prediction only]; Region: COG0517 585396007476 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585396007477 Transporter associated domain; Region: CorC_HlyC; smart01091 585396007478 putative assembly protein; Provisional; Region: PRK10833 585396007479 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585396007480 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 585396007481 trimer interface [polypeptide binding]; other site 585396007482 active site 585396007483 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 585396007484 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 585396007485 ATP-binding site [chemical binding]; other site 585396007486 Sugar specificity; other site 585396007487 Pyrimidine base specificity; other site 585396007488 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 585396007489 putative diguanylate cyclase; Provisional; Region: PRK09776 585396007490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585396007491 putative active site [active] 585396007492 heme pocket [chemical binding]; other site 585396007493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585396007494 putative active site [active] 585396007495 heme pocket [chemical binding]; other site 585396007496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585396007497 putative active site [active] 585396007498 heme pocket [chemical binding]; other site 585396007499 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396007500 metal binding site [ion binding]; metal-binding site 585396007501 active site 585396007502 I-site; other site 585396007503 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396007504 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 585396007505 AlkA N-terminal domain; Region: AlkA_N; smart01009 585396007506 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585396007507 minor groove reading motif; other site 585396007508 helix-hairpin-helix signature motif; other site 585396007509 substrate binding pocket [chemical binding]; other site 585396007510 active site 585396007511 putative chaperone; Provisional; Region: PRK11678 585396007512 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 585396007513 nucleotide binding site [chemical binding]; other site 585396007514 putative NEF/HSP70 interaction site [polypeptide binding]; other site 585396007515 SBD interface [polypeptide binding]; other site 585396007516 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 585396007517 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 585396007518 substrate binding site [chemical binding]; other site 585396007519 activation loop (A-loop); other site 585396007520 Y-family of DNA polymerases; Region: PolY; cl12025 585396007521 Protein phosphatase 2C; Region: PP2C_2; pfam13672 585396007522 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 585396007523 metal ion-dependent adhesion site (MIDAS); other site 585396007524 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 585396007525 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396007526 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396007527 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 585396007528 Protein export membrane protein; Region: SecD_SecF; cl14618 585396007529 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 585396007530 putative transporter; Provisional; Region: PRK10504 585396007531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396007532 putative substrate translocation pore; other site 585396007533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396007534 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 585396007535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585396007536 dimerization interface [polypeptide binding]; other site 585396007537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396007538 dimer interface [polypeptide binding]; other site 585396007539 phosphorylation site [posttranslational modification] 585396007540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396007541 ATP binding site [chemical binding]; other site 585396007542 Mg2+ binding site [ion binding]; other site 585396007543 G-X-G motif; other site 585396007544 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 585396007545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396007546 active site 585396007547 phosphorylation site [posttranslational modification] 585396007548 intermolecular recognition site; other site 585396007549 dimerization interface [polypeptide binding]; other site 585396007550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396007551 DNA binding site [nucleotide binding] 585396007552 Uncharacterized conserved protein [Function unknown]; Region: COG3422 585396007553 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 585396007554 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 585396007555 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 585396007556 putative protease; Provisional; Region: PRK15452 585396007557 Peptidase family U32; Region: Peptidase_U32; pfam01136 585396007558 lipid kinase; Reviewed; Region: PRK13054 585396007559 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 585396007560 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585396007561 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585396007562 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585396007563 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 585396007564 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 585396007565 putative NAD(P) binding site [chemical binding]; other site 585396007566 catalytic Zn binding site [ion binding]; other site 585396007567 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 585396007568 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 585396007569 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 585396007570 active site 585396007571 P-loop; other site 585396007572 phosphorylation site [posttranslational modification] 585396007573 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585396007574 active site 585396007575 phosphorylation site [posttranslational modification] 585396007576 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 585396007577 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 585396007578 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585396007579 intersubunit interface [polypeptide binding]; other site 585396007580 active site 585396007581 zinc binding site [ion binding]; other site 585396007582 Na+ binding site [ion binding]; other site 585396007583 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 585396007584 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 585396007585 putative active site; other site 585396007586 catalytic residue [active] 585396007587 nucleoside transporter; Region: 2A0110; TIGR00889 585396007588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396007589 putative substrate translocation pore; other site 585396007590 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 585396007591 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585396007592 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 585396007593 substrate binding site [chemical binding]; other site 585396007594 ATP binding site [chemical binding]; other site 585396007595 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585396007596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396007597 DNA-binding site [nucleotide binding]; DNA binding site 585396007598 UTRA domain; Region: UTRA; pfam07702 585396007599 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 585396007600 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 585396007601 active site 585396007602 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 585396007603 dimer interface [polypeptide binding]; other site 585396007604 substrate binding site [chemical binding]; other site 585396007605 ATP binding site [chemical binding]; other site 585396007606 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 585396007607 substrate binding site [chemical binding]; other site 585396007608 multimerization interface [polypeptide binding]; other site 585396007609 ATP binding site [chemical binding]; other site 585396007610 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 585396007611 putative metal binding site [ion binding]; other site 585396007612 putative homodimer interface [polypeptide binding]; other site 585396007613 putative homotetramer interface [polypeptide binding]; other site 585396007614 putative homodimer-homodimer interface [polypeptide binding]; other site 585396007615 putative allosteric switch controlling residues; other site 585396007616 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 585396007617 Predicted integral membrane protein [Function unknown]; Region: COG5455 585396007618 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 585396007619 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 585396007620 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 585396007621 PapC N-terminal domain; Region: PapC_N; pfam13954 585396007622 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585396007623 PapC C-terminal domain; Region: PapC_C; pfam13953 585396007624 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 585396007625 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585396007626 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585396007627 Fimbrial protein; Region: Fimbrial; cl01416 585396007628 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 585396007629 antiporter inner membrane protein; Provisional; Region: PRK11670 585396007630 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 585396007631 Walker A motif; other site 585396007632 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 585396007633 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 585396007634 active site 585396007635 HIGH motif; other site 585396007636 KMSKS motif; other site 585396007637 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 585396007638 tRNA binding surface [nucleotide binding]; other site 585396007639 anticodon binding site; other site 585396007640 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 585396007641 dimer interface [polypeptide binding]; other site 585396007642 putative tRNA-binding site [nucleotide binding]; other site 585396007643 DNA-binding transcriptional regulator MolR, N-terminal fragment 585396007644 DNA-binding transcriptional regulator MolR, C-terminal fragment 585396007645 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 585396007646 MoxR-like ATPases [General function prediction only]; Region: COG0714 585396007647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396007648 Walker A motif; other site 585396007649 ATP binding site [chemical binding]; other site 585396007650 Walker B motif; other site 585396007651 arginine finger; other site 585396007652 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 585396007653 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 585396007654 metal ion-dependent adhesion site (MIDAS); other site 585396007655 conserved predicted protein, N-terminal part 585396007656 conserved predicted protein, C-terminal part 585396007657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 585396007658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 585396007659 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 585396007660 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 585396007661 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 585396007662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396007663 active site 585396007664 phosphorylation site [posttranslational modification] 585396007665 intermolecular recognition site; other site 585396007666 dimerization interface [polypeptide binding]; other site 585396007667 LytTr DNA-binding domain; Region: LytTR; pfam04397 585396007668 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 585396007669 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 585396007670 GAF domain; Region: GAF; pfam01590 585396007671 Histidine kinase; Region: His_kinase; pfam06580 585396007672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396007673 ATP binding site [chemical binding]; other site 585396007674 Mg2+ binding site [ion binding]; other site 585396007675 G-X-G motif; other site 585396007676 transcriptional regulator MirA; Provisional; Region: PRK15043 585396007677 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 585396007678 DNA binding residues [nucleotide binding] 585396007679 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 585396007680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396007681 dimer interface [polypeptide binding]; other site 585396007682 conserved gate region; other site 585396007683 putative PBP binding loops; other site 585396007684 ABC-ATPase subunit interface; other site 585396007685 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 585396007686 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 585396007687 Walker A/P-loop; other site 585396007688 ATP binding site [chemical binding]; other site 585396007689 Q-loop/lid; other site 585396007690 ABC transporter signature motif; other site 585396007691 Walker B; other site 585396007692 D-loop; other site 585396007693 H-loop/switch region; other site 585396007694 CBS domain; Region: CBS; pfam00571 585396007695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396007696 dimer interface [polypeptide binding]; other site 585396007697 conserved gate region; other site 585396007698 ABC-ATPase subunit interface; other site 585396007699 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 585396007700 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 585396007701 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 585396007702 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 585396007703 D-lactate dehydrogenase; Provisional; Region: PRK11183 585396007704 FAD binding domain; Region: FAD_binding_4; pfam01565 585396007705 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 585396007706 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 585396007707 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 585396007708 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 585396007709 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585396007710 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585396007711 oxidoreductase; Provisional; Region: PRK12743 585396007712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585396007713 NAD(P) binding site [chemical binding]; other site 585396007714 active site 585396007715 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 585396007716 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 585396007717 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585396007718 FMN binding site [chemical binding]; other site 585396007719 active site 585396007720 catalytic residues [active] 585396007721 substrate binding site [chemical binding]; other site 585396007722 hypothetical protein; Provisional; Region: PRK01821 585396007723 hypothetical protein; Provisional; Region: PRK10711 585396007724 cytidine deaminase; Provisional; Region: PRK09027 585396007725 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 585396007726 active site 585396007727 catalytic motif [active] 585396007728 Zn binding site [ion binding]; other site 585396007729 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 585396007730 active site 585396007731 catalytic motif [active] 585396007732 Zn binding site [ion binding]; other site 585396007733 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585396007734 putative active site [active] 585396007735 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 585396007736 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 585396007737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585396007738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396007739 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 585396007740 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 585396007741 homodimer interface [polypeptide binding]; other site 585396007742 active site 585396007743 FMN binding site [chemical binding]; other site 585396007744 substrate binding site [chemical binding]; other site 585396007745 4Fe-4S binding domain; Region: Fer4; pfam00037 585396007746 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585396007747 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585396007748 TM-ABC transporter signature motif; other site 585396007749 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585396007750 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 585396007751 Walker A/P-loop; other site 585396007752 ATP binding site [chemical binding]; other site 585396007753 Q-loop/lid; other site 585396007754 ABC transporter signature motif; other site 585396007755 Walker B; other site 585396007756 D-loop; other site 585396007757 H-loop/switch region; other site 585396007758 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585396007759 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 585396007760 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 585396007761 ligand binding site [chemical binding]; other site 585396007762 calcium binding site [ion binding]; other site 585396007763 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 585396007764 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396007765 DNA binding site [nucleotide binding] 585396007766 domain linker motif; other site 585396007767 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585396007768 dimerization interface (closed form) [polypeptide binding]; other site 585396007769 ligand binding site [chemical binding]; other site 585396007770 Predicted membrane protein [Function unknown]; Region: COG2311 585396007771 hypothetical protein; Provisional; Region: PRK10835 585396007772 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 585396007773 homodecamer interface [polypeptide binding]; other site 585396007774 GTP cyclohydrolase I; Provisional; Region: PLN03044 585396007775 active site 585396007776 putative catalytic site residues [active] 585396007777 zinc binding site [ion binding]; other site 585396007778 GTP-CH-I/GFRP interaction surface; other site 585396007779 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 585396007780 S-formylglutathione hydrolase; Region: PLN02442 585396007781 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 585396007782 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585396007783 N-terminal plug; other site 585396007784 ligand-binding site [chemical binding]; other site 585396007785 lysine transporter; Provisional; Region: PRK10836 585396007786 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 585396007787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396007788 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 585396007789 putative dimerization interface [polypeptide binding]; other site 585396007790 conserved hypothetical integral membrane protein; Region: TIGR00698 585396007791 endonuclease IV; Provisional; Region: PRK01060 585396007792 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585396007793 AP (apurinic/apyrimidinic) site pocket; other site 585396007794 DNA interaction; other site 585396007795 Metal-binding active site; metal-binding site 585396007796 predicted kinase, C-terminal part 585396007797 predicted nucleoside transporter, N-terminal part 585396007798 predicted nucleoside transporter, N-terminal part 585396007799 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585396007800 active site 585396007801 tetramer interface [polypeptide binding]; other site 585396007802 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 585396007803 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585396007804 ligand binding site [chemical binding]; other site 585396007805 flexible hinge region; other site 585396007806 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 585396007807 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 585396007808 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 585396007809 Nucleoside recognition; Region: Gate; pfam07670 585396007810 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 585396007811 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 585396007812 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 585396007813 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585396007814 substrate binding site [chemical binding]; other site 585396007815 ATP binding site [chemical binding]; other site 585396007816 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 585396007817 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 585396007818 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585396007819 active site 585396007820 P-loop; other site 585396007821 phosphorylation site [posttranslational modification] 585396007822 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 585396007823 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 585396007824 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 585396007825 putative substrate binding site [chemical binding]; other site 585396007826 putative ATP binding site [chemical binding]; other site 585396007827 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 585396007828 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585396007829 active site 585396007830 phosphorylation site [posttranslational modification] 585396007831 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585396007832 dimerization domain swap beta strand [polypeptide binding]; other site 585396007833 regulatory protein interface [polypeptide binding]; other site 585396007834 active site 585396007835 regulatory phosphorylation site [posttranslational modification]; other site 585396007836 sugar efflux transporter B; Provisional; Region: PRK15011 585396007837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396007838 putative substrate translocation pore; other site 585396007839 Flagellin N-methylase; Region: FliB; pfam03692 585396007840 elongation factor P; Provisional; Region: PRK04542 585396007841 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 585396007842 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 585396007843 RNA binding site [nucleotide binding]; other site 585396007844 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 585396007845 RNA binding site [nucleotide binding]; other site 585396007846 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 585396007847 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585396007848 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585396007849 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 585396007850 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 585396007851 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 585396007852 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585396007853 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 585396007854 active site 585396007855 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 585396007856 NlpC/P60 family; Region: NLPC_P60; pfam00877 585396007857 phage resistance protein; Provisional; Region: PRK10551 585396007858 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585396007859 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396007860 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 585396007861 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 585396007862 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 585396007863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396007864 dimer interface [polypeptide binding]; other site 585396007865 conserved gate region; other site 585396007866 putative PBP binding loops; other site 585396007867 ABC-ATPase subunit interface; other site 585396007868 microcin C ABC transporter permease; Provisional; Region: PRK15021 585396007869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396007870 dimer interface [polypeptide binding]; other site 585396007871 conserved gate region; other site 585396007872 ABC-ATPase subunit interface; other site 585396007873 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 585396007874 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396007875 Walker A/P-loop; other site 585396007876 ATP binding site [chemical binding]; other site 585396007877 Q-loop/lid; other site 585396007878 ABC transporter signature motif; other site 585396007879 Walker B; other site 585396007880 D-loop; other site 585396007881 H-loop/switch region; other site 585396007882 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585396007883 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396007884 Walker A/P-loop; other site 585396007885 ATP binding site [chemical binding]; other site 585396007886 Q-loop/lid; other site 585396007887 ABC transporter signature motif; other site 585396007888 Walker B; other site 585396007889 D-loop; other site 585396007890 H-loop/switch region; other site 585396007891 hypothetical protein; Provisional; Region: PRK11835 585396007892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396007893 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 585396007894 putative substrate translocation pore; other site 585396007895 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 585396007896 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585396007897 RNA binding surface [nucleotide binding]; other site 585396007898 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 585396007899 active site 585396007900 uracil binding [chemical binding]; other site 585396007901 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 585396007902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585396007903 ATP binding site [chemical binding]; other site 585396007904 putative Mg++ binding site [ion binding]; other site 585396007905 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396007906 nucleotide binding region [chemical binding]; other site 585396007907 ATP-binding site [chemical binding]; other site 585396007908 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 585396007909 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 585396007910 5S rRNA interface [nucleotide binding]; other site 585396007911 CTC domain interface [polypeptide binding]; other site 585396007912 L16 interface [polypeptide binding]; other site 585396007913 Nucleoid-associated protein [General function prediction only]; Region: COG3081 585396007914 nucleoid-associated protein NdpA; Validated; Region: PRK00378 585396007915 hypothetical protein; Provisional; Region: PRK13689 585396007916 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 585396007917 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 585396007918 Sulfatase; Region: Sulfatase; pfam00884 585396007919 Prophage ECO111_P14, untypable 585396007920 integrase; Provisional; Region: PRK09692 585396007921 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585396007922 active site 585396007923 Int/Topo IB signature motif; other site 585396007924 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 585396007925 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 585396007926 AAA domain; Region: AAA_25; pfam13481 585396007927 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 585396007928 Walker A motif; other site 585396007929 ATP binding site [chemical binding]; other site 585396007930 Walker B motif; other site 585396007931 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 585396007932 Phage capsid family; Region: Phage_capsid; pfam05065 585396007933 predicted autotransporter outer membrane protein, C-terminal part 585396007934 predicted autotransporter outer membrane protein, N-terminal part 585396007935 transcriptional regulator NarP; Provisional; Region: PRK10403 585396007936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396007937 active site 585396007938 phosphorylation site [posttranslational modification] 585396007939 intermolecular recognition site; other site 585396007940 dimerization interface [polypeptide binding]; other site 585396007941 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396007942 DNA binding residues [nucleotide binding] 585396007943 dimerization interface [polypeptide binding]; other site 585396007944 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 585396007945 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 585396007946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585396007947 binding surface 585396007948 TPR motif; other site 585396007949 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 585396007950 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 585396007951 catalytic residues [active] 585396007952 central insert; other site 585396007953 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 585396007954 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 585396007955 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 585396007956 heme exporter protein CcmC; Region: ccmC; TIGR01191 585396007957 heme exporter protein CcmB; Region: ccmB; TIGR01190 585396007958 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 585396007959 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 585396007960 Walker A/P-loop; other site 585396007961 ATP binding site [chemical binding]; other site 585396007962 Q-loop/lid; other site 585396007963 ABC transporter signature motif; other site 585396007964 Walker B; other site 585396007965 D-loop; other site 585396007966 H-loop/switch region; other site 585396007967 cytochrome c-type protein NapC; Provisional; Region: PRK10617 585396007968 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 585396007969 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 585396007970 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 585396007971 4Fe-4S binding domain; Region: Fer4_5; pfam12801 585396007972 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585396007973 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 585396007974 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 585396007975 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 585396007976 [4Fe-4S] binding site [ion binding]; other site 585396007977 molybdopterin cofactor binding site; other site 585396007978 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 585396007979 molybdopterin cofactor binding site; other site 585396007980 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 585396007981 ferredoxin-type protein; Provisional; Region: PRK10194 585396007982 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 585396007983 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 585396007984 secondary substrate binding site; other site 585396007985 primary substrate binding site; other site 585396007986 inhibition loop; other site 585396007987 dimerization interface [polypeptide binding]; other site 585396007988 malate:quinone oxidoreductase; Validated; Region: PRK05257 585396007989 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 585396007990 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 585396007991 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 585396007992 Walker A/P-loop; other site 585396007993 ATP binding site [chemical binding]; other site 585396007994 Q-loop/lid; other site 585396007995 ABC transporter signature motif; other site 585396007996 Walker B; other site 585396007997 D-loop; other site 585396007998 H-loop/switch region; other site 585396007999 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 585396008000 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 585396008001 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 585396008002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396008003 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396008004 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 585396008005 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585396008006 DNA binding site [nucleotide binding] 585396008007 active site 585396008008 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 585396008009 ApbE family; Region: ApbE; pfam02424 585396008010 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585396008011 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585396008012 trimer interface [polypeptide binding]; other site 585396008013 eyelet of channel; other site 585396008014 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 585396008015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396008016 ATP binding site [chemical binding]; other site 585396008017 G-X-G motif; other site 585396008018 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585396008019 putative binding surface; other site 585396008020 active site 585396008021 transcriptional regulator RcsB; Provisional; Region: PRK10840 585396008022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396008023 active site 585396008024 phosphorylation site [posttranslational modification] 585396008025 intermolecular recognition site; other site 585396008026 dimerization interface [polypeptide binding]; other site 585396008027 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396008028 DNA binding residues [nucleotide binding] 585396008029 dimerization interface [polypeptide binding]; other site 585396008030 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 585396008031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396008032 dimer interface [polypeptide binding]; other site 585396008033 phosphorylation site [posttranslational modification] 585396008034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396008035 ATP binding site [chemical binding]; other site 585396008036 Mg2+ binding site [ion binding]; other site 585396008037 G-X-G motif; other site 585396008038 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 585396008039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396008040 active site 585396008041 phosphorylation site [posttranslational modification] 585396008042 intermolecular recognition site; other site 585396008043 dimerization interface [polypeptide binding]; other site 585396008044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 585396008045 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 585396008046 Predicted secreted protein [Function unknown]; Region: COG5445 585396008047 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 585396008048 Predicted secreted protein [Function unknown]; Region: COG5445 585396008049 Stage II sporulation protein; Region: SpoIID; pfam08486 585396008050 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 585396008051 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 585396008052 MG2 domain; Region: A2M_N; pfam01835 585396008053 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 585396008054 Alpha-2-macroglobulin family; Region: A2M; pfam00207 585396008055 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 585396008056 Prophage ECO111_P15, lambda-like phage 585396008057 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585396008058 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585396008059 ORF11CD3 domain; Region: ORF11CD3; pfam10549 585396008060 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585396008061 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585396008062 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585396008063 catalytic residues [active] 585396008064 Lysis protein S; Region: Lysis_S; pfam04971 585396008065 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 585396008066 Prophage ECO111_P15; conserved predicted protein, partial 585396008067 Antitermination protein; Region: Antiterm; pfam03589 585396008068 Antitermination protein; Region: Antiterm; pfam03589 585396008069 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 585396008070 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585396008071 active site 585396008072 metal binding site [ion binding]; metal-binding site 585396008073 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 585396008074 HNH endonuclease; Region: HNH_3; pfam13392 585396008075 AP2 domain; Region: AP2; pfam00847 585396008076 Prophage ECO111_P15; conserved predicted protein, N-terminal part 585396008077 Excisionase-like protein; Region: Exc; pfam07825 585396008078 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 585396008079 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 585396008080 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 585396008081 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 585396008082 dimer interface [polypeptide binding]; other site 585396008083 active site 585396008084 Int/Topo IB signature motif; other site 585396008085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 585396008086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 585396008087 DNA gyrase subunit A; Validated; Region: PRK05560 585396008088 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 585396008089 CAP-like domain; other site 585396008090 active site 585396008091 primary dimer interface [polypeptide binding]; other site 585396008092 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585396008093 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585396008094 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585396008095 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585396008096 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585396008097 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585396008098 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 585396008099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396008100 S-adenosylmethionine binding site [chemical binding]; other site 585396008101 adhesin; Provisional; Region: PRK09752 585396008102 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585396008103 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585396008104 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 585396008105 ATP cone domain; Region: ATP-cone; pfam03477 585396008106 Class I ribonucleotide reductase; Region: RNR_I; cd01679 585396008107 active site 585396008108 dimer interface [polypeptide binding]; other site 585396008109 catalytic residues [active] 585396008110 effector binding site; other site 585396008111 R2 peptide binding site; other site 585396008112 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 585396008113 dimer interface [polypeptide binding]; other site 585396008114 putative radical transfer pathway; other site 585396008115 diiron center [ion binding]; other site 585396008116 tyrosyl radical; other site 585396008117 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585396008118 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585396008119 catalytic loop [active] 585396008120 iron binding site [ion binding]; other site 585396008121 hypothetical protein; Provisional; Region: PRK09902 585396008122 hypothetical protein; Provisional; Region: PRK09729 585396008123 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 585396008124 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 585396008125 active site 585396008126 catalytic site [active] 585396008127 metal binding site [ion binding]; metal-binding site 585396008128 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 585396008129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396008130 putative substrate translocation pore; other site 585396008131 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 585396008132 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585396008133 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585396008134 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 585396008135 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 585396008136 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 585396008137 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585396008138 Cysteine-rich domain; Region: CCG; pfam02754 585396008139 Cysteine-rich domain; Region: CCG; pfam02754 585396008140 hypothetical protein; Provisional; Region: PRK09956 585396008141 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585396008142 predicted 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, C-terminal fragment 585396008143 hypothetical protein; Provisional; Region: PRK03673 585396008144 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 585396008145 putative MPT binding site; other site 585396008146 Competence-damaged protein; Region: CinA; cl00666 585396008147 YfaZ precursor; Region: YfaZ; pfam07437 585396008148 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 585396008149 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 585396008150 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 585396008151 catalytic core [active] 585396008152 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 585396008153 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 585396008154 inhibitor-cofactor binding pocket; inhibition site 585396008155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396008156 catalytic residue [active] 585396008157 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 585396008158 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 585396008159 Ligand binding site; other site 585396008160 Putative Catalytic site; other site 585396008161 DXD motif; other site 585396008162 fused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'-decarboxylase, N-terminal fragment 585396008163 fused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'-decarboxylase, C-terminal fragment 585396008164 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 585396008165 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 585396008166 putative active site [active] 585396008167 putative catalytic site [active] 585396008168 putative Zn binding site [ion binding]; other site 585396008169 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 585396008170 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 585396008171 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 585396008172 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 585396008173 signal transduction protein PmrD; Provisional; Region: PRK15450 585396008174 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 585396008175 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 585396008176 acyl-activating enzyme (AAE) consensus motif; other site 585396008177 putative AMP binding site [chemical binding]; other site 585396008178 putative active site [active] 585396008179 putative CoA binding site [chemical binding]; other site 585396008180 O-succinylbenzoate synthase; Provisional; Region: PRK05105 585396008181 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 585396008182 active site 585396008183 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585396008184 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 585396008185 substrate binding site [chemical binding]; other site 585396008186 oxyanion hole (OAH) forming residues; other site 585396008187 trimer interface [polypeptide binding]; other site 585396008188 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 585396008189 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 585396008190 nucleophilic elbow; other site 585396008191 catalytic triad; other site 585396008192 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 585396008193 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 585396008194 dimer interface [polypeptide binding]; other site 585396008195 tetramer interface [polypeptide binding]; other site 585396008196 PYR/PP interface [polypeptide binding]; other site 585396008197 TPP binding site [chemical binding]; other site 585396008198 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 585396008199 TPP-binding site; other site 585396008200 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 585396008201 isochorismate synthases; Region: isochor_syn; TIGR00543 585396008202 hypothetical protein; Provisional; Region: PRK10404 585396008203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396008204 Coenzyme A binding pocket [chemical binding]; other site 585396008205 ribonuclease BN; Region: true_RNase_BN; TIGR02649 585396008206 deubiquitinase; Provisional; Region: PRK11836 585396008207 von Willebrand factor; Region: vWF_A; pfam12450 585396008208 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 585396008209 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 585396008210 metal ion-dependent adhesion site (MIDAS); other site 585396008211 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 585396008212 M28 Zn-Peptidases; Region: M28_like_1; cd05640 585396008213 Peptidase family M28; Region: Peptidase_M28; pfam04389 585396008214 metal binding site [ion binding]; metal-binding site 585396008215 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 585396008216 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 585396008217 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585396008218 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 585396008219 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585396008220 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 585396008221 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 585396008222 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585396008223 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 585396008224 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 585396008225 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 585396008226 4Fe-4S binding domain; Region: Fer4; pfam00037 585396008227 4Fe-4S binding domain; Region: Fer4; pfam00037 585396008228 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 585396008229 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 585396008230 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585396008231 catalytic loop [active] 585396008232 iron binding site [ion binding]; other site 585396008233 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 585396008234 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 585396008235 [4Fe-4S] binding site [ion binding]; other site 585396008236 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 585396008237 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 585396008238 SLBB domain; Region: SLBB; pfam10531 585396008239 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 585396008240 NADH dehydrogenase subunit E; Validated; Region: PRK07539 585396008241 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 585396008242 putative dimer interface [polypeptide binding]; other site 585396008243 [2Fe-2S] cluster binding site [ion binding]; other site 585396008244 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 585396008245 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 585396008246 NADH dehydrogenase subunit D; Validated; Region: PRK06075 585396008247 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 585396008248 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 585396008249 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 585396008250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396008251 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 585396008252 putative dimerization interface [polypeptide binding]; other site 585396008253 aminotransferase AlaT; Validated; Region: PRK09265 585396008254 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585396008255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396008256 homodimer interface [polypeptide binding]; other site 585396008257 catalytic residue [active] 585396008258 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585396008259 Zn2+ binding site [ion binding]; other site 585396008260 Mg2+ binding site [ion binding]; other site 585396008261 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 585396008262 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585396008263 TrkA-C domain; Region: TrkA_C; pfam02080 585396008264 TrkA-C domain; Region: TrkA_C; pfam02080 585396008265 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 585396008266 putative phosphatase; Provisional; Region: PRK11587 585396008267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396008268 motif II; other site 585396008269 hypothetical protein; Validated; Region: PRK05445 585396008270 hypothetical protein; Provisional; Region: PRK01816 585396008271 propionate/acetate kinase; Provisional; Region: PRK12379 585396008272 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 585396008273 phosphate acetyltransferase; Reviewed; Region: PRK05632 585396008274 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585396008275 DRTGG domain; Region: DRTGG; pfam07085 585396008276 phosphate acetyltransferase; Region: pta; TIGR00651 585396008277 hypothetical protein; Provisional; Region: PRK11588 585396008278 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 585396008279 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 585396008280 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 585396008281 nudix motif; other site 585396008282 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 585396008283 active site 585396008284 metal binding site [ion binding]; metal-binding site 585396008285 homotetramer interface [polypeptide binding]; other site 585396008286 predicted enzyme, C-terminal fragment 585396008287 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 585396008288 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 585396008289 C-terminal domain interface [polypeptide binding]; other site 585396008290 GSH binding site (G-site) [chemical binding]; other site 585396008291 dimer interface [polypeptide binding]; other site 585396008292 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 585396008293 N-terminal domain interface [polypeptide binding]; other site 585396008294 putative dimer interface [polypeptide binding]; other site 585396008295 active site 585396008296 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 585396008297 homooctamer interface [polypeptide binding]; other site 585396008298 active site 585396008299 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 585396008300 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 585396008301 putative NAD(P) binding site [chemical binding]; other site 585396008302 putative active site [active] 585396008303 putative transposase; Provisional; Region: PRK09857 585396008304 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585396008305 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 585396008306 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585396008307 Walker A/P-loop; other site 585396008308 ATP binding site [chemical binding]; other site 585396008309 Q-loop/lid; other site 585396008310 ABC transporter signature motif; other site 585396008311 Walker B; other site 585396008312 D-loop; other site 585396008313 H-loop/switch region; other site 585396008314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396008315 dimer interface [polypeptide binding]; other site 585396008316 conserved gate region; other site 585396008317 putative PBP binding loops; other site 585396008318 ABC-ATPase subunit interface; other site 585396008319 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585396008320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396008321 dimer interface [polypeptide binding]; other site 585396008322 conserved gate region; other site 585396008323 putative PBP binding loops; other site 585396008324 ABC-ATPase subunit interface; other site 585396008325 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 585396008326 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396008327 substrate binding pocket [chemical binding]; other site 585396008328 membrane-bound complex binding site; other site 585396008329 hinge residues; other site 585396008330 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 585396008331 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396008332 substrate binding pocket [chemical binding]; other site 585396008333 membrane-bound complex binding site; other site 585396008334 hinge residues; other site 585396008335 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 585396008336 Flavoprotein; Region: Flavoprotein; pfam02441 585396008337 amidophosphoribosyltransferase; Provisional; Region: PRK09246 585396008338 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 585396008339 active site 585396008340 tetramer interface [polypeptide binding]; other site 585396008341 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585396008342 active site 585396008343 colicin V production protein; Provisional; Region: PRK10845 585396008344 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 585396008345 cell division protein DedD; Provisional; Region: PRK11633 585396008346 Sporulation related domain; Region: SPOR; pfam05036 585396008347 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 585396008348 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585396008349 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585396008350 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 585396008351 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 585396008352 hypothetical protein; Provisional; Region: PRK10847 585396008353 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585396008354 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 585396008355 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 585396008356 dimerization interface 3.5A [polypeptide binding]; other site 585396008357 active site 585396008358 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 585396008359 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585396008360 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 585396008361 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 585396008362 ligand binding site [chemical binding]; other site 585396008363 NAD binding site [chemical binding]; other site 585396008364 catalytic site [active] 585396008365 homodimer interface [polypeptide binding]; other site 585396008366 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 585396008367 putative transporter; Provisional; Region: PRK12382 585396008368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396008369 putative substrate translocation pore; other site 585396008370 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 585396008371 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 585396008372 dimer interface [polypeptide binding]; other site 585396008373 active site 585396008374 Uncharacterized conserved protein [Function unknown]; Region: COG4121 585396008375 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 585396008376 YfcL protein; Region: YfcL; pfam08891 585396008377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 585396008378 hypothetical protein; Provisional; Region: PRK10621 585396008379 Predicted permeases [General function prediction only]; Region: COG0730 585396008380 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 585396008381 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 585396008382 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 585396008383 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 585396008384 Tetramer interface [polypeptide binding]; other site 585396008385 active site 585396008386 FMN-binding site [chemical binding]; other site 585396008387 HemK family putative methylases; Region: hemK_fam; TIGR00536 585396008388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396008389 S-adenosylmethionine binding site [chemical binding]; other site 585396008390 hypothetical protein; Provisional; Region: PRK04946 585396008391 Smr domain; Region: Smr; pfam01713 585396008392 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 585396008393 Fimbrial protein; Region: Fimbrial; cl01416 585396008394 Fimbrial protein; Region: Fimbrial; cl01416 585396008395 Fimbrial protein; Region: Fimbrial; cl01416 585396008396 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 585396008397 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585396008398 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585396008399 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 585396008400 PapC N-terminal domain; Region: PapC_N; pfam13954 585396008401 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585396008402 PapC C-terminal domain; Region: PapC_C; pfam13953 585396008403 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585396008404 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585396008405 catalytic core [active] 585396008406 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 585396008407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585396008408 substrate binding site [chemical binding]; other site 585396008409 oxyanion hole (OAH) forming residues; other site 585396008410 trimer interface [polypeptide binding]; other site 585396008411 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585396008412 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585396008413 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 585396008414 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585396008415 dimer interface [polypeptide binding]; other site 585396008416 active site 585396008417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 585396008418 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 585396008419 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 585396008420 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 585396008421 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 585396008422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396008423 putative substrate translocation pore; other site 585396008424 putative fructokinase, C-terminal fragment 585396008425 putative fructokinase, N-terminal fragment 585396008426 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 585396008427 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 585396008428 substrate binding [chemical binding]; other site 585396008429 active site 585396008430 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 585396008431 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396008432 DNA binding site [nucleotide binding] 585396008433 domain linker motif; other site 585396008434 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 585396008435 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 585396008436 putative dimerization interface [polypeptide binding]; other site 585396008437 putative ligand binding site [chemical binding]; other site 585396008438 transport protein, C-terminal fragment 585396008439 D-serine ammonia-lyase DsdA, N-terminal fragment 585396008440 D-serine ammonia-lyase DsdA, C-terminal fragment 585396008441 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 585396008442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396008443 putative substrate translocation pore; other site 585396008444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396008445 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 585396008446 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396008447 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396008448 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 585396008449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396008450 active site 585396008451 phosphorylation site [posttranslational modification] 585396008452 intermolecular recognition site; other site 585396008453 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396008454 DNA binding residues [nucleotide binding] 585396008455 dimerization interface [polypeptide binding]; other site 585396008456 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 585396008457 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396008458 substrate binding pocket [chemical binding]; other site 585396008459 membrane-bound complex binding site; other site 585396008460 hinge residues; other site 585396008461 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396008462 substrate binding pocket [chemical binding]; other site 585396008463 membrane-bound complex binding site; other site 585396008464 hinge residues; other site 585396008465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396008466 dimer interface [polypeptide binding]; other site 585396008467 phosphorylation site [posttranslational modification] 585396008468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396008469 ATP binding site [chemical binding]; other site 585396008470 Mg2+ binding site [ion binding]; other site 585396008471 G-X-G motif; other site 585396008472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396008473 active site 585396008474 phosphorylation site [posttranslational modification] 585396008475 intermolecular recognition site; other site 585396008476 dimerization interface [polypeptide binding]; other site 585396008477 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585396008478 putative binding surface; other site 585396008479 active site 585396008480 putative CoA-transferase; Provisional; Region: PRK11430 585396008481 CoA-transferase family III; Region: CoA_transf_3; pfam02515 585396008482 putative transporter YfdV; Provisional; Region: PRK09903 585396008483 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 585396008484 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585396008485 PYR/PP interface [polypeptide binding]; other site 585396008486 dimer interface [polypeptide binding]; other site 585396008487 TPP binding site [chemical binding]; other site 585396008488 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585396008489 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 585396008490 TPP-binding site; other site 585396008491 dimer interface [polypeptide binding]; other site 585396008492 formyl-coenzyme A transferase; Provisional; Region: PRK05398 585396008493 CoA-transferase family III; Region: CoA_transf_3; pfam02515 585396008494 hypothetical protein; Provisional; Region: PRK10316 585396008495 YfdX protein; Region: YfdX; pfam10938 585396008496 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 585396008497 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585396008498 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585396008499 putative acyl-acceptor binding pocket; other site 585396008500 aminotransferase; Validated; Region: PRK08175 585396008501 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585396008502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396008503 homodimer interface [polypeptide binding]; other site 585396008504 catalytic residue [active] 585396008505 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 585396008506 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 585396008507 GAF domain; Region: GAF; pfam01590 585396008508 Histidine kinase; Region: His_kinase; pfam06580 585396008509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396008510 ATP binding site [chemical binding]; other site 585396008511 Mg2+ binding site [ion binding]; other site 585396008512 G-X-G motif; other site 585396008513 predicted response regulator in two-component system with YpdA, N-terminal fragment 585396008514 predicted response regulator in two-component system with YpdA, C-terminal fragment 585396008515 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585396008516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396008517 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585396008518 dimerization domain swap beta strand [polypeptide binding]; other site 585396008519 regulatory protein interface [polypeptide binding]; other site 585396008520 active site 585396008521 regulatory phosphorylation site [posttranslational modification]; other site 585396008522 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585396008523 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 585396008524 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585396008525 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585396008526 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585396008527 active site 585396008528 phosphorylation site [posttranslational modification] 585396008529 exoaminopeptidase; Provisional; Region: PRK09961 585396008530 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 585396008531 oligomer interface [polypeptide binding]; other site 585396008532 active site 585396008533 metal binding site [ion binding]; metal-binding site 585396008534 aminopeptidase; Provisional; Region: PRK09795 585396008535 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 585396008536 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 585396008537 active site 585396008538 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 585396008539 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585396008540 active site 585396008541 P-loop; other site 585396008542 phosphorylation site [posttranslational modification] 585396008543 glucokinase, proteobacterial type; Region: glk; TIGR00749 585396008544 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585396008545 nucleotide binding site [chemical binding]; other site 585396008546 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585396008547 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 585396008548 Cl- selectivity filter; other site 585396008549 Cl- binding residues [ion binding]; other site 585396008550 pore gating glutamate residue; other site 585396008551 dimer interface [polypeptide binding]; other site 585396008552 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 585396008553 manganese transport protein MntH; Reviewed; Region: PRK00701 585396008554 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 585396008555 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 585396008556 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 585396008557 Nucleoside recognition; Region: Gate; pfam07670 585396008558 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 585396008559 MASE1; Region: MASE1; pfam05231 585396008560 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585396008561 diguanylate cyclase; Region: GGDEF; smart00267 585396008562 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396008563 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 585396008564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396008565 salt bridge; other site 585396008566 non-specific DNA binding site [nucleotide binding]; other site 585396008567 sequence-specific DNA binding site [nucleotide binding]; other site 585396008568 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 585396008569 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 585396008570 active site 585396008571 HIGH motif; other site 585396008572 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 585396008573 active site 585396008574 KMSKS motif; other site 585396008575 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 585396008576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396008577 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 585396008578 putative dimerization interface [polypeptide binding]; other site 585396008579 putative substrate binding pocket [chemical binding]; other site 585396008580 nucleoside transporter; Region: 2A0110; TIGR00889 585396008581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396008582 putative substrate translocation pore; other site 585396008583 purine nucleoside phosphorylase; Provisional; Region: PRK08202 585396008584 hypothetical protein; Provisional; Region: PRK11528 585396008585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585396008586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396008587 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 585396008588 putative dimerization interface [polypeptide binding]; other site 585396008589 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 585396008590 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 585396008591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 585396008592 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 585396008593 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 585396008594 nucleotide binding pocket [chemical binding]; other site 585396008595 K-X-D-G motif; other site 585396008596 catalytic site [active] 585396008597 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 585396008598 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 585396008599 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 585396008600 Dimer interface [polypeptide binding]; other site 585396008601 BRCT sequence motif; other site 585396008602 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 585396008603 cell division protein ZipA; Provisional; Region: PRK03427 585396008604 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 585396008605 FtsZ protein binding site [polypeptide binding]; other site 585396008606 putative sulfate transport protein CysZ; Validated; Region: PRK04949 585396008607 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 585396008608 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 585396008609 dimer interface [polypeptide binding]; other site 585396008610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396008611 catalytic residue [active] 585396008612 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585396008613 dimerization domain swap beta strand [polypeptide binding]; other site 585396008614 regulatory protein interface [polypeptide binding]; other site 585396008615 active site 585396008616 regulatory phosphorylation site [posttranslational modification]; other site 585396008617 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 585396008618 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585396008619 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585396008620 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585396008621 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585396008622 HPr interaction site; other site 585396008623 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585396008624 active site 585396008625 phosphorylation site [posttranslational modification] 585396008626 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 585396008627 dimer interface [polypeptide binding]; other site 585396008628 pyridoxamine kinase; Validated; Region: PRK05756 585396008629 pyridoxal binding site [chemical binding]; other site 585396008630 ATP binding site [chemical binding]; other site 585396008631 hypothetical protein; Provisional; Region: PRK10318 585396008632 cysteine synthase B; Region: cysM; TIGR01138 585396008633 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 585396008634 dimer interface [polypeptide binding]; other site 585396008635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396008636 catalytic residue [active] 585396008637 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 585396008638 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 585396008639 Walker A/P-loop; other site 585396008640 ATP binding site [chemical binding]; other site 585396008641 Q-loop/lid; other site 585396008642 ABC transporter signature motif; other site 585396008643 Walker B; other site 585396008644 D-loop; other site 585396008645 H-loop/switch region; other site 585396008646 TOBE-like domain; Region: TOBE_3; pfam12857 585396008647 sulfate transport protein; Provisional; Region: cysT; CHL00187 585396008648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396008649 dimer interface [polypeptide binding]; other site 585396008650 conserved gate region; other site 585396008651 putative PBP binding loops; other site 585396008652 ABC-ATPase subunit interface; other site 585396008653 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 585396008654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396008655 dimer interface [polypeptide binding]; other site 585396008656 conserved gate region; other site 585396008657 putative PBP binding loops; other site 585396008658 ABC-ATPase subunit interface; other site 585396008659 thiosulfate transporter subunit; Provisional; Region: PRK10852 585396008660 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 585396008661 short chain dehydrogenase; Provisional; Region: PRK08226 585396008662 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 585396008663 NAD binding site [chemical binding]; other site 585396008664 homotetramer interface [polypeptide binding]; other site 585396008665 homodimer interface [polypeptide binding]; other site 585396008666 active site 585396008667 transcriptional regulator MurR; Provisional; Region: PRK15482 585396008668 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585396008669 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585396008670 putative active site [active] 585396008671 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 585396008672 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 585396008673 putative active site [active] 585396008674 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 585396008675 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585396008676 active site turn [active] 585396008677 phosphorylation site [posttranslational modification] 585396008678 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585396008679 putative periplasmic esterase; Provisional; Region: PRK03642 585396008680 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585396008681 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 585396008682 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 585396008683 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 585396008684 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 585396008685 putative acetyltransferase; Provisional; Region: PRK03624 585396008686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396008687 Coenzyme A binding pocket [chemical binding]; other site 585396008688 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 585396008689 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585396008690 active site 585396008691 metal binding site [ion binding]; metal-binding site 585396008692 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 585396008693 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 585396008694 transcriptional regulator EutR; Provisional; Region: PRK10130 585396008695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396008696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396008697 carboxysome structural protein EutK; Provisional; Region: PRK15466 585396008698 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 585396008699 Hexamer interface [polypeptide binding]; other site 585396008700 Hexagonal pore residue; other site 585396008701 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 585396008702 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 585396008703 putative hexamer interface [polypeptide binding]; other site 585396008704 putative hexagonal pore; other site 585396008705 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 585396008706 putative hexamer interface [polypeptide binding]; other site 585396008707 putative hexagonal pore; other site 585396008708 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 585396008709 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 585396008710 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 585396008711 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 585396008712 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 585396008713 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 585396008714 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 585396008715 active site 585396008716 metal binding site [ion binding]; metal-binding site 585396008717 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 585396008718 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585396008719 nucleotide binding site [chemical binding]; other site 585396008720 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 585396008721 putative catalytic cysteine [active] 585396008722 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 585396008723 Hexamer/Pentamer interface [polypeptide binding]; other site 585396008724 central pore; other site 585396008725 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 585396008726 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 585396008727 Hexamer interface [polypeptide binding]; other site 585396008728 Putative hexagonal pore residue; other site 585396008729 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 585396008730 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 585396008731 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 585396008732 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 585396008733 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 585396008734 G1 box; other site 585396008735 GTP/Mg2+ binding site [chemical binding]; other site 585396008736 G2 box; other site 585396008737 Switch I region; other site 585396008738 G3 box; other site 585396008739 Switch II region; other site 585396008740 G4 box; other site 585396008741 G5 box; other site 585396008742 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 585396008743 putative hexamer interface [polypeptide binding]; other site 585396008744 putative hexagonal pore; other site 585396008745 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 585396008746 Malic enzyme, N-terminal domain; Region: malic; pfam00390 585396008747 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 585396008748 putative NAD(P) binding site [chemical binding]; other site 585396008749 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 585396008750 transaldolase-like protein; Provisional; Region: PTZ00411 585396008751 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 585396008752 active site 585396008753 dimer interface [polypeptide binding]; other site 585396008754 catalytic residue [active] 585396008755 transketolase; Reviewed; Region: PRK12753 585396008756 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 585396008757 TPP-binding site [chemical binding]; other site 585396008758 dimer interface [polypeptide binding]; other site 585396008759 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585396008760 PYR/PP interface [polypeptide binding]; other site 585396008761 dimer interface [polypeptide binding]; other site 585396008762 TPP binding site [chemical binding]; other site 585396008763 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585396008764 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 585396008765 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 585396008766 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585396008767 dimer interface [polypeptide binding]; other site 585396008768 ADP-ribose binding site [chemical binding]; other site 585396008769 active site 585396008770 nudix motif; other site 585396008771 metal binding site [ion binding]; metal-binding site 585396008772 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 585396008773 4Fe-4S binding domain; Region: Fer4; pfam00037 585396008774 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585396008775 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396008776 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 585396008777 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 585396008778 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585396008779 dimerization interface [polypeptide binding]; other site 585396008780 Histidine kinase; Region: HisKA_3; pfam07730 585396008781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396008782 ATP binding site [chemical binding]; other site 585396008783 Mg2+ binding site [ion binding]; other site 585396008784 G-X-G motif; other site 585396008785 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 585396008786 Protein export membrane protein; Region: SecD_SecF; cl14618 585396008787 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 585396008788 ArsC family; Region: ArsC; pfam03960 585396008789 putative catalytic residues [active] 585396008790 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 585396008791 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 585396008792 metal binding site [ion binding]; metal-binding site 585396008793 dimer interface [polypeptide binding]; other site 585396008794 hypothetical protein; Provisional; Region: PRK13664 585396008795 putative hydrolase; Provisional; Region: PRK11460 585396008796 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 585396008797 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 585396008798 Helicase; Region: Helicase_RecD; pfam05127 585396008799 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 585396008800 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 585396008801 Predicted metalloprotease [General function prediction only]; Region: COG2321 585396008802 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 585396008803 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 585396008804 oligomeric interface; other site 585396008805 putative active site [active] 585396008806 homodimer interface [polypeptide binding]; other site 585396008807 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 585396008808 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 585396008809 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 585396008810 ATP binding site [chemical binding]; other site 585396008811 active site 585396008812 substrate binding site [chemical binding]; other site 585396008813 lipoprotein; Provisional; Region: PRK11679 585396008814 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 585396008815 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 585396008816 dihydrodipicolinate synthase; Region: dapA; TIGR00674 585396008817 dimer interface [polypeptide binding]; other site 585396008818 active site 585396008819 catalytic residue [active] 585396008820 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 585396008821 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 585396008822 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 585396008823 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 585396008824 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 585396008825 catalytic triad [active] 585396008826 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585396008827 4Fe-4S binding domain; Region: Fer4; pfam00037 585396008828 hydrogenase 4 subunit B; Validated; Region: PRK06521 585396008829 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585396008830 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 585396008831 NADH dehydrogenase; Region: NADHdh; cl00469 585396008832 hydrogenase 4 subunit D; Validated; Region: PRK06525 585396008833 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585396008834 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 585396008835 hydrogenase 4 subunit F; Validated; Region: PRK06458 585396008836 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585396008837 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 585396008838 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 585396008839 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 585396008840 hydrogenase 4 subunit H; Validated; Region: PRK08222 585396008841 4Fe-4S binding domain; Region: Fer4; pfam00037 585396008842 hydrogenase 4, Fe-S subunit HyfI, N-terminal fragment 585396008843 hydrogenase 4, Fe-S subunit HyfI, C-terminal fragment 585396008844 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 585396008845 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 585396008846 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585396008847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396008848 Walker A motif; other site 585396008849 ATP binding site [chemical binding]; other site 585396008850 Walker B motif; other site 585396008851 arginine finger; other site 585396008852 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585396008853 putative formate transporter; Provisional; Region: focB; PRK09713 585396008854 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 585396008855 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585396008856 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 585396008857 Peptidase family M48; Region: Peptidase_M48; cl12018 585396008858 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 585396008859 ArsC family; Region: ArsC; pfam03960 585396008860 catalytic residues [active] 585396008861 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 585396008862 DNA replication initiation factor; Provisional; Region: PRK08084 585396008863 uracil transporter; Provisional; Region: PRK10720 585396008864 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585396008865 active site 585396008866 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 585396008867 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 585396008868 dimerization interface [polypeptide binding]; other site 585396008869 putative ATP binding site [chemical binding]; other site 585396008870 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 585396008871 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 585396008872 active site 585396008873 substrate binding site [chemical binding]; other site 585396008874 cosubstrate binding site; other site 585396008875 catalytic site [active] 585396008876 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 585396008877 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 585396008878 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 585396008879 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 585396008880 domain interface [polypeptide binding]; other site 585396008881 active site 585396008882 catalytic site [active] 585396008883 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 585396008884 putative active site [active] 585396008885 catalytic site [active] 585396008886 exopolyphosphatase; Provisional; Region: PRK10854 585396008887 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 585396008888 MASE1; Region: MASE1; pfam05231 585396008889 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585396008890 diguanylate cyclase; Region: GGDEF; smart00267 585396008891 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396008892 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 585396008893 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 585396008894 GMP synthase; Reviewed; Region: guaA; PRK00074 585396008895 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 585396008896 AMP/PPi binding site [chemical binding]; other site 585396008897 candidate oxyanion hole; other site 585396008898 catalytic triad [active] 585396008899 potential glutamine specificity residues [chemical binding]; other site 585396008900 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 585396008901 ATP Binding subdomain [chemical binding]; other site 585396008902 Ligand Binding sites [chemical binding]; other site 585396008903 Dimerization subdomain; other site 585396008904 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 585396008905 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585396008906 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 585396008907 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 585396008908 active site 585396008909 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 585396008910 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 585396008911 generic binding surface II; other site 585396008912 generic binding surface I; other site 585396008913 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 585396008914 GTP-binding protein Der; Reviewed; Region: PRK00093 585396008915 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 585396008916 G1 box; other site 585396008917 GTP/Mg2+ binding site [chemical binding]; other site 585396008918 Switch I region; other site 585396008919 G2 box; other site 585396008920 Switch II region; other site 585396008921 G3 box; other site 585396008922 G4 box; other site 585396008923 G5 box; other site 585396008924 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 585396008925 G1 box; other site 585396008926 GTP/Mg2+ binding site [chemical binding]; other site 585396008927 Switch I region; other site 585396008928 G2 box; other site 585396008929 G3 box; other site 585396008930 Switch II region; other site 585396008931 G4 box; other site 585396008932 G5 box; other site 585396008933 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 585396008934 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 585396008935 Trp docking motif [polypeptide binding]; other site 585396008936 active site 585396008937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 585396008938 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 585396008939 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 585396008940 dimer interface [polypeptide binding]; other site 585396008941 motif 1; other site 585396008942 active site 585396008943 motif 2; other site 585396008944 motif 3; other site 585396008945 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 585396008946 anticodon binding site; other site 585396008947 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 585396008948 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 585396008949 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 585396008950 cytoskeletal protein RodZ; Provisional; Region: PRK10856 585396008951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396008952 non-specific DNA binding site [nucleotide binding]; other site 585396008953 salt bridge; other site 585396008954 sequence-specific DNA binding site [nucleotide binding]; other site 585396008955 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 585396008956 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 585396008957 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396008958 FeS/SAM binding site; other site 585396008959 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 585396008960 active site 585396008961 multimer interface [polypeptide binding]; other site 585396008962 penicillin-binding protein 1C; Provisional; Region: PRK11240 585396008963 Transglycosylase; Region: Transgly; pfam00912 585396008964 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585396008965 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 585396008966 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 585396008967 MG2 domain; Region: A2M_N; pfam01835 585396008968 Alpha-2-macroglobulin family; Region: A2M; pfam00207 585396008969 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 585396008970 surface patch; other site 585396008971 thioester region; other site 585396008972 specificity defining residues; other site 585396008973 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 585396008974 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 585396008975 active site residue [active] 585396008976 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 585396008977 active site residue [active] 585396008978 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 585396008979 aminopeptidase B; Provisional; Region: PRK05015 585396008980 Peptidase; Region: DUF3663; pfam12404 585396008981 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 585396008982 interface (dimer of trimers) [polypeptide binding]; other site 585396008983 Substrate-binding/catalytic site; other site 585396008984 Zn-binding sites [ion binding]; other site 585396008985 hypothetical protein; Provisional; Region: PRK10721 585396008986 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585396008987 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585396008988 catalytic loop [active] 585396008989 iron binding site [ion binding]; other site 585396008990 chaperone protein HscA; Provisional; Region: hscA; PRK05183 585396008991 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 585396008992 nucleotide binding site [chemical binding]; other site 585396008993 putative NEF/HSP70 interaction site [polypeptide binding]; other site 585396008994 SBD interface [polypeptide binding]; other site 585396008995 co-chaperone HscB; Provisional; Region: hscB; PRK05014 585396008996 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585396008997 HSP70 interaction site [polypeptide binding]; other site 585396008998 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 585396008999 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 585396009000 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 585396009001 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 585396009002 trimerization site [polypeptide binding]; other site 585396009003 active site 585396009004 cysteine desulfurase; Provisional; Region: PRK14012 585396009005 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 585396009006 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585396009007 catalytic residue [active] 585396009008 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 585396009009 Rrf2 family protein; Region: rrf2_super; TIGR00738 585396009010 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 585396009011 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 585396009012 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 585396009013 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 585396009014 active site 585396009015 dimerization interface [polypeptide binding]; other site 585396009016 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 585396009017 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585396009018 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 585396009019 PRD domain; Region: PRD; pfam00874 585396009020 PRD domain; Region: PRD; pfam00874 585396009021 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 585396009022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396009023 putative substrate translocation pore; other site 585396009024 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 585396009025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396009026 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585396009027 dimerization interface [polypeptide binding]; other site 585396009028 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 585396009029 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 585396009030 iron-sulfur cluster [ion binding]; other site 585396009031 [2Fe-2S] cluster binding site [ion binding]; other site 585396009032 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 585396009033 beta subunit interface [polypeptide binding]; other site 585396009034 alpha subunit interface [polypeptide binding]; other site 585396009035 active site 585396009036 substrate binding site [chemical binding]; other site 585396009037 Fe binding site [ion binding]; other site 585396009038 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 585396009039 inter-subunit interface; other site 585396009040 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 585396009041 [2Fe-2S] cluster binding site [ion binding]; other site 585396009042 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 585396009043 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 585396009044 NAD binding site [chemical binding]; other site 585396009045 active site 585396009046 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 585396009047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396009048 Predicted membrane protein [Function unknown]; Region: COG2259 585396009049 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 585396009050 active site 585396009051 catalytic residues [active] 585396009052 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585396009053 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 585396009054 putative NAD(P) binding site [chemical binding]; other site 585396009055 catalytic Zn binding site [ion binding]; other site 585396009056 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585396009057 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585396009058 TM-ABC transporter signature motif; other site 585396009059 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585396009060 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585396009061 Walker A/P-loop; other site 585396009062 ATP binding site [chemical binding]; other site 585396009063 Q-loop/lid; other site 585396009064 ABC transporter signature motif; other site 585396009065 Walker B; other site 585396009066 D-loop; other site 585396009067 H-loop/switch region; other site 585396009068 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585396009069 predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily, C-terminal fragment 585396009070 predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily, N-terminal fragment 585396009071 conserved predicted protein, C-terminal fragment 585396009072 conserved predicted protein, N-terminal fragment 585396009073 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 585396009074 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585396009075 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585396009076 nucleotide binding site [chemical binding]; other site 585396009077 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 585396009078 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 585396009079 dimer interface [polypeptide binding]; other site 585396009080 active site 585396009081 glycine-pyridoxal phosphate binding site [chemical binding]; other site 585396009082 folate binding site [chemical binding]; other site 585396009083 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 585396009084 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 585396009085 heme-binding site [chemical binding]; other site 585396009086 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 585396009087 FAD binding pocket [chemical binding]; other site 585396009088 FAD binding motif [chemical binding]; other site 585396009089 phosphate binding motif [ion binding]; other site 585396009090 beta-alpha-beta structure motif; other site 585396009091 NAD binding pocket [chemical binding]; other site 585396009092 Heme binding pocket [chemical binding]; other site 585396009093 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 585396009094 Nitrogen regulatory protein P-II; Region: P-II; smart00938 585396009095 response regulator GlrR; Provisional; Region: PRK15115 585396009096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396009097 active site 585396009098 phosphorylation site [posttranslational modification] 585396009099 intermolecular recognition site; other site 585396009100 dimerization interface [polypeptide binding]; other site 585396009101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396009102 Walker A motif; other site 585396009103 ATP binding site [chemical binding]; other site 585396009104 Walker B motif; other site 585396009105 arginine finger; other site 585396009106 hypothetical protein; Provisional; Region: PRK10722 585396009107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 585396009108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396009109 dimer interface [polypeptide binding]; other site 585396009110 phosphorylation site [posttranslational modification] 585396009111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396009112 ATP binding site [chemical binding]; other site 585396009113 Mg2+ binding site [ion binding]; other site 585396009114 G-X-G motif; other site 585396009115 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 585396009116 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 585396009117 dimerization interface [polypeptide binding]; other site 585396009118 ATP binding site [chemical binding]; other site 585396009119 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 585396009120 dimerization interface [polypeptide binding]; other site 585396009121 ATP binding site [chemical binding]; other site 585396009122 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 585396009123 putative active site [active] 585396009124 catalytic triad [active] 585396009125 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 585396009126 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396009127 substrate binding pocket [chemical binding]; other site 585396009128 membrane-bound complex binding site; other site 585396009129 hinge residues; other site 585396009130 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585396009131 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585396009132 catalytic residue [active] 585396009133 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 585396009134 nucleoside/Zn binding site; other site 585396009135 dimer interface [polypeptide binding]; other site 585396009136 catalytic motif [active] 585396009137 hypothetical protein; Provisional; Region: PRK11590 585396009138 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 585396009139 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585396009140 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 585396009141 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585396009142 putative active site [active] 585396009143 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 585396009144 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 585396009145 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 585396009146 active site 585396009147 hydrophilic channel; other site 585396009148 dimerization interface [polypeptide binding]; other site 585396009149 catalytic residues [active] 585396009150 active site lid [active] 585396009151 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 585396009152 Recombination protein O N terminal; Region: RecO_N; pfam11967 585396009153 Recombination protein O C terminal; Region: RecO_C; pfam02565 585396009154 GTPase Era; Reviewed; Region: era; PRK00089 585396009155 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 585396009156 G1 box; other site 585396009157 GTP/Mg2+ binding site [chemical binding]; other site 585396009158 Switch I region; other site 585396009159 G2 box; other site 585396009160 Switch II region; other site 585396009161 G3 box; other site 585396009162 G4 box; other site 585396009163 G5 box; other site 585396009164 KH domain; Region: KH_2; pfam07650 585396009165 ribonuclease III; Reviewed; Region: rnc; PRK00102 585396009166 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 585396009167 dimerization interface [polypeptide binding]; other site 585396009168 active site 585396009169 metal binding site [ion binding]; metal-binding site 585396009170 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 585396009171 dsRNA binding site [nucleotide binding]; other site 585396009172 signal peptidase I; Provisional; Region: PRK10861 585396009173 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 585396009174 Catalytic site [active] 585396009175 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 585396009176 GTP-binding protein LepA; Provisional; Region: PRK05433 585396009177 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 585396009178 G1 box; other site 585396009179 putative GEF interaction site [polypeptide binding]; other site 585396009180 GTP/Mg2+ binding site [chemical binding]; other site 585396009181 Switch I region; other site 585396009182 G2 box; other site 585396009183 G3 box; other site 585396009184 Switch II region; other site 585396009185 G4 box; other site 585396009186 G5 box; other site 585396009187 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 585396009188 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 585396009189 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 585396009190 SoxR reducing system protein RseC; Provisional; Region: PRK10862 585396009191 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 585396009192 anti-sigma E factor; Provisional; Region: rseB; PRK09455 585396009193 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 585396009194 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 585396009195 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 585396009196 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 585396009197 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585396009198 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585396009199 DNA binding residues [nucleotide binding] 585396009200 L-aspartate oxidase; Provisional; Region: PRK09077 585396009201 L-aspartate oxidase; Provisional; Region: PRK06175 585396009202 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585396009203 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 585396009204 Methyltransferase domain; Region: Methyltransf_26; pfam13659 585396009205 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 585396009206 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585396009207 ATP binding site [chemical binding]; other site 585396009208 Mg++ binding site [ion binding]; other site 585396009209 motif III; other site 585396009210 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396009211 nucleotide binding region [chemical binding]; other site 585396009212 ATP-binding site [chemical binding]; other site 585396009213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585396009214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396009215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 585396009216 dimerization interface [polypeptide binding]; other site 585396009217 neutral amino-acid efflux system, C-terminal part 585396009218 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 585396009219 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 585396009220 ligand binding site [chemical binding]; other site 585396009221 active site 585396009222 UGI interface [polypeptide binding]; other site 585396009223 catalytic site [active] 585396009224 putative methyltransferase; Provisional; Region: PRK10864 585396009225 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 585396009226 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585396009227 thioredoxin 2; Provisional; Region: PRK10996 585396009228 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 585396009229 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 585396009230 catalytic residues [active] 585396009231 Uncharacterized conserved protein [Function unknown]; Region: COG3148 585396009232 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 585396009233 CoA binding domain; Region: CoA_binding_2; pfam13380 585396009234 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 585396009235 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 585396009236 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 585396009237 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 585396009238 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 585396009239 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 585396009240 domain interface [polypeptide binding]; other site 585396009241 putative active site [active] 585396009242 catalytic site [active] 585396009243 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 585396009244 domain interface [polypeptide binding]; other site 585396009245 putative active site [active] 585396009246 catalytic site [active] 585396009247 lipoprotein; Provisional; Region: PRK10759 585396009248 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 585396009249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396009250 putative substrate translocation pore; other site 585396009251 protein disaggregation chaperone; Provisional; Region: PRK10865 585396009252 Clp amino terminal domain; Region: Clp_N; pfam02861 585396009253 Clp amino terminal domain; Region: Clp_N; pfam02861 585396009254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396009255 Walker A motif; other site 585396009256 ATP binding site [chemical binding]; other site 585396009257 Walker B motif; other site 585396009258 arginine finger; other site 585396009259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396009260 Walker A motif; other site 585396009261 ATP binding site [chemical binding]; other site 585396009262 Walker B motif; other site 585396009263 arginine finger; other site 585396009264 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 585396009265 hypothetical protein; Provisional; Region: PRK10723 585396009266 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 585396009267 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 585396009268 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585396009269 RNA binding surface [nucleotide binding]; other site 585396009270 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585396009271 active site 585396009272 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 585396009273 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 585396009274 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 585396009275 30S subunit binding site; other site 585396009276 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 585396009277 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 585396009278 Prephenate dehydratase; Region: PDT; pfam00800 585396009279 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 585396009280 putative L-Phe binding site [chemical binding]; other site 585396009281 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 585396009282 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 585396009283 prephenate dehydrogenase; Validated; Region: PRK08507 585396009284 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 585396009285 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585396009286 lipoprotein; Provisional; Region: PRK11443 585396009287 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 585396009288 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 585396009289 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 585396009290 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396009291 metal binding site [ion binding]; metal-binding site 585396009292 active site 585396009293 I-site; other site 585396009294 putative outer membrane lipoprotein; Provisional; Region: PRK09967 585396009295 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585396009296 ligand binding site [chemical binding]; other site 585396009297 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 585396009298 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 585396009299 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 585396009300 RimM N-terminal domain; Region: RimM; pfam01782 585396009301 PRC-barrel domain; Region: PRC; pfam05239 585396009302 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 585396009303 signal recognition particle protein; Provisional; Region: PRK10867 585396009304 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 585396009305 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 585396009306 P loop; other site 585396009307 GTP binding site [chemical binding]; other site 585396009308 Signal peptide binding domain; Region: SRP_SPB; pfam02978 585396009309 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 585396009310 hypothetical protein; Provisional; Region: PRK11573 585396009311 Domain of unknown function DUF21; Region: DUF21; pfam01595 585396009312 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585396009313 Transporter associated domain; Region: CorC_HlyC; smart01091 585396009314 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 585396009315 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 585396009316 dimer interface [polypeptide binding]; other site 585396009317 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 585396009318 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 585396009319 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 585396009320 recombination and repair protein; Provisional; Region: PRK10869 585396009321 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 585396009322 Walker A/P-loop; other site 585396009323 ATP binding site [chemical binding]; other site 585396009324 Q-loop/lid; other site 585396009325 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 585396009326 Q-loop/lid; other site 585396009327 ABC transporter signature motif; other site 585396009328 Walker B; other site 585396009329 D-loop; other site 585396009330 H-loop/switch region; other site 585396009331 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 585396009332 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 585396009333 hypothetical protein; Validated; Region: PRK01777 585396009334 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 585396009335 putative coenzyme Q binding site [chemical binding]; other site 585396009336 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 585396009337 SmpB-tmRNA interface; other site 585396009338 Prophage ECO111_P16, lambda-like phage 585396009339 DinI-like family; Region: DinI; pfam06183 585396009340 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396009341 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585396009342 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585396009343 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396009344 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585396009345 Phage-related protein, tail component [Function unknown]; Region: COG4733 585396009346 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585396009347 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585396009348 Interdomain contacts; other site 585396009349 Cytokine receptor motif; other site 585396009350 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585396009351 Fibronectin type III protein; Region: DUF3672; pfam12421 585396009352 Phage-related protein, tail component [Function unknown]; Region: COG4723 585396009353 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585396009354 MPN+ (JAMM) motif; other site 585396009355 Zinc-binding site [ion binding]; other site 585396009356 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585396009357 NlpC/P60 family; Region: NLPC_P60; cl17555 585396009358 Phage-related protein [Function unknown]; Region: gp18; COG4672 585396009359 Phage-related protein [Function unknown]; Region: COG4718 585396009360 Phage-related minor tail protein [Function unknown]; Region: COG5281 585396009361 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585396009362 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585396009363 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585396009364 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 585396009365 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 585396009366 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585396009367 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585396009368 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585396009369 Transposase; Region: HTH_Tnp_1; cl17663 585396009370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396009371 putative transposase OrfB; Reviewed; Region: PHA02517 585396009372 HTH-like domain; Region: HTH_21; pfam13276 585396009373 Integrase core domain; Region: rve; pfam00665 585396009374 Integrase core domain; Region: rve_3; pfam13683 585396009375 Prophage ECO111_P16; predicted DNA-binding protein, C-terminal part 585396009376 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 585396009377 Phage NinH protein; Region: Phage_NinH; pfam06322 585396009378 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585396009379 Ribosome inactivating protein; Region: RIP; pfam00161 585396009380 Shiga-like toxin beta subunit; Region: SLT_beta; pfam02258 585396009381 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585396009382 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585396009383 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 585396009384 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585396009385 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585396009386 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585396009387 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 585396009388 Clp protease; Region: CLP_protease; pfam00574 585396009389 oligomer interface [polypeptide binding]; other site 585396009390 active site residues [active] 585396009391 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 585396009392 Uncharacterized conserved protein [Function unknown]; Region: COG5471 585396009393 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 585396009394 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585396009395 Prophage ECO111_P16; predicted minor tail protein, N-terminal fragment 585396009396 putative transposase OrfB; Reviewed; Region: PHA02517 585396009397 HTH-like domain; Region: HTH_21; pfam13276 585396009398 Integrase core domain; Region: rve; pfam00665 585396009399 Integrase core domain; Region: rve_3; pfam13683 585396009400 Transposase; Region: HTH_Tnp_1; cl17663 585396009401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396009402 Integrative element ECO111_IE04 585396009403 Integrative element ECO111_IE04; predicted integrase, C-terminal fragment 585396009404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 585396009405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396009406 ATP binding site [chemical binding]; other site 585396009407 Mg2+ binding site [ion binding]; other site 585396009408 G-X-G motif; other site 585396009409 conserved predicted protein, N-terminal part 585396009410 conserved predicted protein, C-terminal part 585396009411 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 585396009412 substrate binding pocket [chemical binding]; other site 585396009413 active site 585396009414 iron coordination sites [ion binding]; other site 585396009415 Predicted dehydrogenase [General function prediction only]; Region: COG0579 585396009416 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585396009417 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 585396009418 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 585396009419 tetramerization interface [polypeptide binding]; other site 585396009420 NAD(P) binding site [chemical binding]; other site 585396009421 catalytic residues [active] 585396009422 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 585396009423 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585396009424 inhibitor-cofactor binding pocket; inhibition site 585396009425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396009426 catalytic residue [active] 585396009427 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 585396009428 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 585396009429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396009430 DNA-binding site [nucleotide binding]; DNA binding site 585396009431 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585396009432 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 585396009433 bacterial OsmY and nodulation domain; Region: BON; smart00749 585396009434 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585396009435 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 585396009436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585396009437 dimerization interface [polypeptide binding]; other site 585396009438 putative DNA binding site [nucleotide binding]; other site 585396009439 Transcriptional regulators [Transcription]; Region: MarR; COG1846 585396009440 putative Zn2+ binding site [ion binding]; other site 585396009441 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 585396009442 active site residue [active] 585396009443 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 585396009444 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 585396009445 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585396009446 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 585396009447 hypothetical protein; Provisional; Region: PRK10556 585396009448 hypothetical protein; Provisional; Region: PRK10132 585396009449 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 585396009450 catalytic residues [active] 585396009451 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 585396009452 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 585396009453 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 585396009454 Class I ribonucleotide reductase; Region: RNR_I; cd01679 585396009455 active site 585396009456 dimer interface [polypeptide binding]; other site 585396009457 catalytic residues [active] 585396009458 effector binding site; other site 585396009459 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 585396009460 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 585396009461 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 585396009462 dimer interface [polypeptide binding]; other site 585396009463 putative radical transfer pathway; other site 585396009464 diiron center [ion binding]; other site 585396009465 tyrosyl radical; other site 585396009466 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 585396009467 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 585396009468 Walker A/P-loop; other site 585396009469 ATP binding site [chemical binding]; other site 585396009470 Q-loop/lid; other site 585396009471 ABC transporter signature motif; other site 585396009472 Walker B; other site 585396009473 D-loop; other site 585396009474 H-loop/switch region; other site 585396009475 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 585396009476 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 585396009477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396009478 dimer interface [polypeptide binding]; other site 585396009479 conserved gate region; other site 585396009480 putative PBP binding loops; other site 585396009481 ABC-ATPase subunit interface; other site 585396009482 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 585396009483 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 585396009484 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 585396009485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396009486 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 585396009487 putative L-valine exporter; Provisional; Region: PRK10408 585396009488 transcriptional repressor MprA; Provisional; Region: PRK10870 585396009489 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585396009490 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 585396009491 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396009492 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396009493 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 585396009494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396009495 putative substrate translocation pore; other site 585396009496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396009497 S-ribosylhomocysteinase; Provisional; Region: PRK02260 585396009498 glutamate--cysteine ligase; Provisional; Region: PRK02107 585396009499 Predicted membrane protein [Function unknown]; Region: COG1238 585396009500 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 585396009501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396009502 motif II; other site 585396009503 carbon storage regulator; Provisional; Region: PRK01712 585396009504 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 585396009505 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 585396009506 motif 1; other site 585396009507 active site 585396009508 motif 2; other site 585396009509 motif 3; other site 585396009510 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 585396009511 DHHA1 domain; Region: DHHA1; pfam02272 585396009512 recombination regulator RecX; Reviewed; Region: recX; PRK00117 585396009513 recombinase A; Provisional; Region: recA; PRK09354 585396009514 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 585396009515 hexamer interface [polypeptide binding]; other site 585396009516 Walker A motif; other site 585396009517 ATP binding site [chemical binding]; other site 585396009518 Walker B motif; other site 585396009519 hypothetical protein; Validated; Region: PRK03661 585396009520 Transglycosylase SLT domain; Region: SLT_2; pfam13406 585396009521 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585396009522 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585396009523 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 585396009524 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 585396009525 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 585396009526 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 585396009527 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 585396009528 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 585396009529 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 585396009530 putative NAD(P) binding site [chemical binding]; other site 585396009531 active site 585396009532 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 585396009533 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 585396009534 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585396009535 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585396009536 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 585396009537 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 585396009538 putative active site [active] 585396009539 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 585396009540 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 585396009541 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585396009542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396009543 Walker A motif; other site 585396009544 ATP binding site [chemical binding]; other site 585396009545 Walker B motif; other site 585396009546 arginine finger; other site 585396009547 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 585396009548 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 585396009549 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 585396009550 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 585396009551 iron binding site [ion binding]; other site 585396009552 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 585396009553 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585396009554 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396009555 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 585396009556 Acylphosphatase; Region: Acylphosphatase; pfam00708 585396009557 HypF finger; Region: zf-HYPF; pfam07503 585396009558 HypF finger; Region: zf-HYPF; pfam07503 585396009559 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 585396009560 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 585396009561 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 585396009562 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585396009563 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396009564 DNA binding site [nucleotide binding] 585396009565 domain linker motif; other site 585396009566 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585396009567 dimerization interface (closed form) [polypeptide binding]; other site 585396009568 ligand binding site [chemical binding]; other site 585396009569 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 585396009570 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585396009571 active site turn [active] 585396009572 phosphorylation site [posttranslational modification] 585396009573 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 585396009574 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 585396009575 beta-galactosidase; Region: BGL; TIGR03356 585396009576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396009577 non-specific DNA binding site [nucleotide binding]; other site 585396009578 salt bridge; other site 585396009579 sequence-specific DNA binding site [nucleotide binding]; other site 585396009580 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 585396009581 nickel binding site [ion binding]; other site 585396009582 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 585396009583 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 585396009584 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 585396009585 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585396009586 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 585396009587 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 585396009588 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 585396009589 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 585396009590 NADH dehydrogenase; Region: NADHdh; cl00469 585396009591 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 585396009592 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585396009593 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585396009594 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 585396009595 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 585396009596 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 585396009597 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 585396009598 hydrogenase assembly chaperone; Provisional; Region: PRK10409 585396009599 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 585396009600 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 585396009601 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 585396009602 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 585396009603 dimerization interface [polypeptide binding]; other site 585396009604 ATP binding site [chemical binding]; other site 585396009605 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 585396009606 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585396009607 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585396009608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396009609 Walker A motif; other site 585396009610 ATP binding site [chemical binding]; other site 585396009611 Walker B motif; other site 585396009612 arginine finger; other site 585396009613 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 585396009614 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 585396009615 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 585396009616 MutS domain I; Region: MutS_I; pfam01624 585396009617 MutS domain II; Region: MutS_II; pfam05188 585396009618 MutS domain III; Region: MutS_III; pfam05192 585396009619 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 585396009620 Walker A/P-loop; other site 585396009621 ATP binding site [chemical binding]; other site 585396009622 Q-loop/lid; other site 585396009623 ABC transporter signature motif; other site 585396009624 Walker B; other site 585396009625 D-loop; other site 585396009626 H-loop/switch region; other site 585396009627 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 585396009628 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585396009629 active site 585396009630 metal binding site [ion binding]; metal-binding site 585396009631 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585396009632 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585396009633 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585396009634 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 585396009635 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585396009636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 585396009637 putative aldolase; Validated; Region: PRK08130 585396009638 active site 585396009639 intersubunit interface [polypeptide binding]; other site 585396009640 Zn2+ binding site [ion binding]; other site 585396009641 hypothetical protein; Provisional; Region: PRK09989 585396009642 putative transporter; Provisional; Region: PRK09821 585396009643 GntP family permease; Region: GntP_permease; pfam02447 585396009644 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 585396009645 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 585396009646 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 585396009647 Flavoprotein; Region: Flavoprotein; pfam02441 585396009648 MarR family; Region: MarR_2; cl17246 585396009649 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585396009650 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 585396009651 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 585396009652 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585396009653 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585396009654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585396009655 DNA binding residues [nucleotide binding] 585396009656 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 585396009657 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585396009658 Peptidase family M23; Region: Peptidase_M23; pfam01551 585396009659 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 585396009660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396009661 S-adenosylmethionine binding site [chemical binding]; other site 585396009662 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 585396009663 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 585396009664 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 585396009665 Permutation of conserved domain; other site 585396009666 active site 585396009667 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 585396009668 homotrimer interaction site [polypeptide binding]; other site 585396009669 zinc binding site [ion binding]; other site 585396009670 CDP-binding sites; other site 585396009671 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 585396009672 substrate binding site; other site 585396009673 dimer interface; other site 585396009674 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 585396009675 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 585396009676 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 585396009677 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 585396009678 ligand-binding site [chemical binding]; other site 585396009679 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 585396009680 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 585396009681 CysD dimerization site [polypeptide binding]; other site 585396009682 G1 box; other site 585396009683 putative GEF interaction site [polypeptide binding]; other site 585396009684 GTP/Mg2+ binding site [chemical binding]; other site 585396009685 Switch I region; other site 585396009686 G2 box; other site 585396009687 G3 box; other site 585396009688 Switch II region; other site 585396009689 G4 box; other site 585396009690 G5 box; other site 585396009691 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 585396009692 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 585396009693 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 585396009694 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585396009695 Active Sites [active] 585396009696 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 585396009697 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 585396009698 metal binding site [ion binding]; metal-binding site 585396009699 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 585396009700 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 585396009701 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 585396009702 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 585396009703 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 585396009704 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 585396009705 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 585396009706 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 585396009707 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 585396009708 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 585396009709 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 585396009710 Hok/gef family; Region: HOK_GEF; pfam01848 585396009711 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 585396009712 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585396009713 Active Sites [active] 585396009714 sulfite reductase subunit beta; Provisional; Region: PRK13504 585396009715 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585396009716 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585396009717 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 585396009718 Flavodoxin; Region: Flavodoxin_1; pfam00258 585396009719 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 585396009720 FAD binding pocket [chemical binding]; other site 585396009721 FAD binding motif [chemical binding]; other site 585396009722 catalytic residues [active] 585396009723 NAD binding pocket [chemical binding]; other site 585396009724 phosphate binding motif [ion binding]; other site 585396009725 beta-alpha-beta structure motif; other site 585396009726 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 585396009727 homohexamer interface [polypeptide binding]; other site 585396009728 putative substrate stabilizing pore; other site 585396009729 pterin binding site; other site 585396009730 oxidoreductase; Provisional; Region: PRK10015 585396009731 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 585396009732 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 585396009733 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 585396009734 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 585396009735 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 585396009736 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 585396009737 Ligand binding site [chemical binding]; other site 585396009738 Electron transfer flavoprotein domain; Region: ETF; pfam01012 585396009739 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 585396009740 benzoate transport; Region: 2A0115; TIGR00895 585396009741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396009742 putative substrate translocation pore; other site 585396009743 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 585396009744 FAD binding domain; Region: FAD_binding_4; pfam01565 585396009745 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 585396009746 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 585396009747 NADP binding site [chemical binding]; other site 585396009748 homodimer interface [polypeptide binding]; other site 585396009749 active site 585396009750 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585396009751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396009752 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 585396009753 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585396009754 nucleotide binding site [chemical binding]; other site 585396009755 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 585396009756 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 585396009757 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 585396009758 Repair protein; Region: Repair_PSII; pfam04536 585396009759 enolase; Provisional; Region: eno; PRK00077 585396009760 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 585396009761 dimer interface [polypeptide binding]; other site 585396009762 metal binding site [ion binding]; metal-binding site 585396009763 substrate binding pocket [chemical binding]; other site 585396009764 CTP synthetase; Validated; Region: pyrG; PRK05380 585396009765 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 585396009766 Catalytic site [active] 585396009767 active site 585396009768 UTP binding site [chemical binding]; other site 585396009769 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 585396009770 active site 585396009771 putative oxyanion hole; other site 585396009772 catalytic triad [active] 585396009773 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 585396009774 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 585396009775 homodimer interface [polypeptide binding]; other site 585396009776 metal binding site [ion binding]; metal-binding site 585396009777 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 585396009778 homodimer interface [polypeptide binding]; other site 585396009779 active site 585396009780 putative chemical substrate binding site [chemical binding]; other site 585396009781 metal binding site [ion binding]; metal-binding site 585396009782 toxin MazF; Provisional; Region: PRK09907 585396009783 antitoxin MazE; Provisional; Region: PRK09798 585396009784 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 585396009785 HD domain; Region: HD_4; pfam13328 585396009786 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 585396009787 synthetase active site [active] 585396009788 NTP binding site [chemical binding]; other site 585396009789 metal binding site [ion binding]; metal-binding site 585396009790 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 585396009791 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 585396009792 23S rRNA (uracil-5)-methyltransferase, C-terminal fragment 585396009793 23S rRNA (uracil-5)-methyltransferase, N-terminal fragment 585396009794 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 585396009795 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 585396009796 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585396009797 dimerization interface [polypeptide binding]; other site 585396009798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396009799 dimer interface [polypeptide binding]; other site 585396009800 phosphorylation site [posttranslational modification] 585396009801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396009802 ATP binding site [chemical binding]; other site 585396009803 Mg2+ binding site [ion binding]; other site 585396009804 G-X-G motif; other site 585396009805 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 585396009806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396009807 active site 585396009808 phosphorylation site [posttranslational modification] 585396009809 intermolecular recognition site; other site 585396009810 dimerization interface [polypeptide binding]; other site 585396009811 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585396009812 putative binding surface; other site 585396009813 active site 585396009814 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 585396009815 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 585396009816 active site 585396009817 tetramer interface [polypeptide binding]; other site 585396009818 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 585396009819 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 585396009820 active site 585396009821 tetramer interface [polypeptide binding]; other site 585396009822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396009823 D-galactonate transporter; Region: 2A0114; TIGR00893 585396009824 putative substrate translocation pore; other site 585396009825 flavodoxin; Provisional; Region: PRK08105 585396009826 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 585396009827 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 585396009828 probable active site [active] 585396009829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 585396009830 SecY interacting protein Syd; Provisional; Region: PRK04968 585396009831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 585396009832 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 585396009833 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 585396009834 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 585396009835 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 585396009836 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585396009837 serine transporter; Region: stp; TIGR00814 585396009838 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 585396009839 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585396009840 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585396009841 flap endonuclease-like protein; Provisional; Region: PRK09482 585396009842 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 585396009843 active site 585396009844 metal binding site 1 [ion binding]; metal-binding site 585396009845 putative 5' ssDNA interaction site; other site 585396009846 metal binding site 3; metal-binding site 585396009847 metal binding site 2 [ion binding]; metal-binding site 585396009848 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 585396009849 putative DNA binding site [nucleotide binding]; other site 585396009850 putative metal binding site [ion binding]; other site 585396009851 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 585396009852 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 585396009853 dimer interface [polypeptide binding]; other site 585396009854 active site 585396009855 metal binding site [ion binding]; metal-binding site 585396009856 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585396009857 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585396009858 intersubunit interface [polypeptide binding]; other site 585396009859 active site 585396009860 Zn2+ binding site [ion binding]; other site 585396009861 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 585396009862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396009863 putative substrate translocation pore; other site 585396009864 L-fucose isomerase; Provisional; Region: fucI; PRK10991 585396009865 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 585396009866 hexamer (dimer of trimers) interface [polypeptide binding]; other site 585396009867 trimer interface [polypeptide binding]; other site 585396009868 substrate binding site [chemical binding]; other site 585396009869 Mn binding site [ion binding]; other site 585396009870 L-fuculokinase; Provisional; Region: PRK10331 585396009871 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585396009872 nucleotide binding site [chemical binding]; other site 585396009873 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 585396009874 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 585396009875 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585396009876 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585396009877 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 585396009878 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 585396009879 hypothetical protein; Provisional; Region: PRK10873 585396009880 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 585396009881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396009882 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 585396009883 dimerization interface [polypeptide binding]; other site 585396009884 substrate binding pocket [chemical binding]; other site 585396009885 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 585396009886 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 585396009887 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 585396009888 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585396009889 catalytic residue [active] 585396009890 CsdA-binding activator; Provisional; Region: PRK15019 585396009891 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 585396009892 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 585396009893 putative ATP binding site [chemical binding]; other site 585396009894 putative substrate interface [chemical binding]; other site 585396009895 murein transglycosylase A; Provisional; Region: mltA; PRK11162 585396009896 MltA specific insert domain; Region: MltA; pfam03562 585396009897 3D domain; Region: 3D; pfam06725 585396009898 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 585396009899 putative ligand binding site [chemical binding]; other site 585396009900 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 585396009901 putative NAD binding site [chemical binding]; other site 585396009902 catalytic site [active] 585396009903 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 585396009904 putative active site [active] 585396009905 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 585396009906 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585396009907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396009908 homodimer interface [polypeptide binding]; other site 585396009909 catalytic residue [active] 585396009910 fused maltose and glucose-specific PTS enzymes: IIB component, IIC component, C-terminal part 585396009911 fused maltose and glucose-specific PTS enzymes: IIB component, IIC component, N-terminal part 585396009912 CAT RNA binding domain; Region: CAT_RBD; pfam03123 585396009913 PRD domain; Region: PRD; pfam00874 585396009914 PRD domain; Region: PRD; pfam00874 585396009915 AMIN domain; Region: AMIN; pfam11741 585396009916 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585396009917 active site 585396009918 metal binding site [ion binding]; metal-binding site 585396009919 N-acetylglutamate synthase; Validated; Region: PRK05279 585396009920 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 585396009921 putative feedback inhibition sensing region; other site 585396009922 putative nucleotide binding site [chemical binding]; other site 585396009923 putative substrate binding site [chemical binding]; other site 585396009924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396009925 Coenzyme A binding pocket [chemical binding]; other site 585396009926 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 585396009927 AAA domain; Region: AAA_30; pfam13604 585396009928 Family description; Region: UvrD_C_2; pfam13538 585396009929 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 585396009930 protease3; Provisional; Region: PRK15101 585396009931 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 585396009932 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585396009933 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585396009934 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 585396009935 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 585396009936 hypothetical protein; Provisional; Region: PRK10332 585396009937 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 585396009938 hypothetical protein; Provisional; Region: PRK11521 585396009939 hypothetical protein; Provisional; Region: PRK10557 585396009940 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585396009941 hypothetical protein; Provisional; Region: PRK10506 585396009942 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585396009943 thymidylate synthase; Reviewed; Region: thyA; PRK01827 585396009944 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 585396009945 dimerization interface [polypeptide binding]; other site 585396009946 active site 585396009947 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 585396009948 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 585396009949 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585396009950 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585396009951 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585396009952 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585396009953 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 585396009954 putative active site [active] 585396009955 Ap4A binding site [chemical binding]; other site 585396009956 nudix motif; other site 585396009957 putative metal binding site [ion binding]; other site 585396009958 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 585396009959 putative DNA-binding cleft [nucleotide binding]; other site 585396009960 putative DNA clevage site; other site 585396009961 molecular lever; other site 585396009962 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585396009963 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 585396009964 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585396009965 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585396009966 active site 585396009967 catalytic tetrad [active] 585396009968 lysophospholipid transporter LplT; Provisional; Region: PRK11195 585396009969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396009970 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 585396009971 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 585396009972 putative acyl-acceptor binding pocket; other site 585396009973 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 585396009974 acyl-activating enzyme (AAE) consensus motif; other site 585396009975 putative AMP binding site [chemical binding]; other site 585396009976 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 585396009977 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396009978 DNA binding site [nucleotide binding] 585396009979 domain linker motif; other site 585396009980 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585396009981 dimerization interface (closed form) [polypeptide binding]; other site 585396009982 ligand binding site [chemical binding]; other site 585396009983 diaminopimelate decarboxylase; Provisional; Region: PRK11165 585396009984 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 585396009985 active site 585396009986 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585396009987 substrate binding site [chemical binding]; other site 585396009988 catalytic residues [active] 585396009989 dimer interface [polypeptide binding]; other site 585396009990 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 585396009991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396009992 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 585396009993 putative dimerization interface [polypeptide binding]; other site 585396009994 putative racemase; Provisional; Region: PRK10200 585396009995 aspartate racemase; Region: asp_race; TIGR00035 585396009996 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 585396009997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396009998 putative substrate translocation pore; other site 585396009999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396010000 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 585396010001 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 585396010002 NADP binding site [chemical binding]; other site 585396010003 homodimer interface [polypeptide binding]; other site 585396010004 active site 585396010005 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 585396010006 putative acyltransferase; Provisional; Region: PRK05790 585396010007 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585396010008 dimer interface [polypeptide binding]; other site 585396010009 active site 585396010010 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585396010011 serine transporter; Region: stp; TIGR00814 585396010012 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 585396010013 DNA binding residues [nucleotide binding] 585396010014 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 585396010015 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 585396010016 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 585396010017 conserved predicted protein, C-terminal fragment 585396010018 transcriptional regulator; Provisional; Region: PRK11906 585396010019 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 585396010020 DNA binding site [nucleotide binding] 585396010021 TPR motif; other site 585396010022 Tetratricopeptide repeat; Region: TPR_2; pfam07719 585396010023 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 585396010024 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585396010025 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585396010026 catalytic residue [active] 585396010027 conserved predicted protein, C-terminal fragment 585396010028 conserved predicted protein, N-terminal part 585396010029 invasion protein OrgB; Provisional; Region: PRK15322 585396010030 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 585396010031 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 585396010032 type III secretion protein EprJ, N-terminal part 585396010033 type III secretion protein EprI, N-terminal part 585396010034 type III secretion protein EprH, C-terminal fragment 585396010035 type III secretion protein EprH, N-terminal fragment 585396010036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396010037 DNA binding residues [nucleotide binding] 585396010038 type III secretion protein EprS, C-terminal fragment 585396010039 type III secretion protein EprS, middle part of fragment 585396010040 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 585396010041 type III secretion system protein SpaQ; Provisional; Region: PRK15333 585396010042 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 585396010043 type III secretion protein EpaO, C-terminal fragment 585396010044 type III secretion protein EpaO, N-terminal fragment 585396010045 conserved predicted protein, C-terminal part 585396010046 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 585396010047 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585396010048 Peptidase family M23; Region: Peptidase_M23; pfam01551 585396010049 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 585396010050 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 585396010051 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 585396010052 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 585396010053 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 585396010054 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 585396010055 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585396010056 catalytic loop [active] 585396010057 iron binding site [ion binding]; other site 585396010058 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 585396010059 GAF domain; Region: GAF; cl17456 585396010060 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 585396010061 PAS domain; Region: PAS; smart00091 585396010062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396010063 Walker A motif; other site 585396010064 ATP binding site [chemical binding]; other site 585396010065 Walker B motif; other site 585396010066 arginine finger; other site 585396010067 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585396010068 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 585396010069 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585396010070 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585396010071 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 585396010072 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 585396010073 catalytic residue [active] 585396010074 peptidase; Reviewed; Region: PRK13004 585396010075 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 585396010076 putative metal binding site [ion binding]; other site 585396010077 putative dimer interface [polypeptide binding]; other site 585396010078 D-hydantoinase; Region: D-hydantoinase; TIGR02033 585396010079 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 585396010080 tetramer interface [polypeptide binding]; other site 585396010081 active site 585396010082 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585396010083 carbamate kinase; Reviewed; Region: PRK12686 585396010084 putative substrate binding site [chemical binding]; other site 585396010085 homodimer interface [polypeptide binding]; other site 585396010086 nucleotide binding site [chemical binding]; other site 585396010087 nucleotide binding site [chemical binding]; other site 585396010088 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 585396010089 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 585396010090 XdhC Rossmann domain; Region: XdhC_C; pfam13478 585396010091 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 585396010092 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 585396010093 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 585396010094 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 585396010095 Ligand binding site; other site 585396010096 metal-binding site 585396010097 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 585396010098 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585396010099 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585396010100 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396010101 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 585396010102 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 585396010103 active site 585396010104 putative substrate binding pocket [chemical binding]; other site 585396010105 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 585396010106 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 585396010107 putative hypoxanthine oxidase; Provisional; Region: PRK09800 585396010108 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 585396010109 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 585396010110 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 585396010111 uracil-xanthine permease; Region: ncs2; TIGR00801 585396010112 guanine deaminase; Provisional; Region: PRK09228 585396010113 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 585396010114 active site 585396010115 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585396010116 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585396010117 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 585396010118 4Fe-4S binding domain; Region: Fer4; pfam00037 585396010119 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585396010120 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396010121 xanthine permease; Region: pbuX; TIGR03173 585396010122 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 585396010123 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 585396010124 active site 585396010125 metal binding site [ion binding]; metal-binding site 585396010126 nudix motif; other site 585396010127 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 585396010128 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 585396010129 dimer interface [polypeptide binding]; other site 585396010130 putative anticodon binding site; other site 585396010131 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 585396010132 motif 1; other site 585396010133 active site 585396010134 motif 2; other site 585396010135 motif 3; other site 585396010136 peptide chain release factor 2; Validated; Region: prfB; PRK00578 585396010137 This domain is found in peptide chain release factors; Region: PCRF; smart00937 585396010138 RF-1 domain; Region: RF-1; pfam00472 585396010139 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 585396010140 DHH family; Region: DHH; pfam01368 585396010141 DHHA1 domain; Region: DHHA1; pfam02272 585396010142 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 585396010143 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 585396010144 dimerization domain [polypeptide binding]; other site 585396010145 dimer interface [polypeptide binding]; other site 585396010146 catalytic residues [active] 585396010147 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 585396010148 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 585396010149 active site 585396010150 Int/Topo IB signature motif; other site 585396010151 flavodoxin FldB; Provisional; Region: PRK12359 585396010152 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 585396010153 hypothetical protein; Provisional; Region: PRK10878 585396010154 putative global regulator; Reviewed; Region: PRK09559 585396010155 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 585396010156 hemolysin; Provisional; Region: PRK15087 585396010157 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 585396010158 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 585396010159 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 585396010160 beta-galactosidase; Region: BGL; TIGR03356 585396010161 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 585396010162 classical (c) SDRs; Region: SDR_c; cd05233 585396010163 NAD(P) binding site [chemical binding]; other site 585396010164 active site 585396010165 glycine dehydrogenase; Provisional; Region: PRK05367 585396010166 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 585396010167 tetramer interface [polypeptide binding]; other site 585396010168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396010169 catalytic residue [active] 585396010170 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 585396010171 tetramer interface [polypeptide binding]; other site 585396010172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396010173 catalytic residue [active] 585396010174 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 585396010175 lipoyl attachment site [posttranslational modification]; other site 585396010176 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 585396010177 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 585396010178 oxidoreductase; Provisional; Region: PRK08013 585396010179 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 585396010180 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 585396010181 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 585396010182 proline aminopeptidase P II; Provisional; Region: PRK10879 585396010183 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 585396010184 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 585396010185 active site 585396010186 hypothetical protein; Reviewed; Region: PRK01736 585396010187 Z-ring-associated protein; Provisional; Region: PRK10972 585396010188 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 585396010189 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 585396010190 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 585396010191 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 585396010192 ligand binding site [chemical binding]; other site 585396010193 NAD binding site [chemical binding]; other site 585396010194 tetramer interface [polypeptide binding]; other site 585396010195 catalytic site [active] 585396010196 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 585396010197 L-serine binding site [chemical binding]; other site 585396010198 ACT domain interface; other site 585396010199 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 585396010200 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585396010201 active site 585396010202 dimer interface [polypeptide binding]; other site 585396010203 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 585396010204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396010205 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 585396010206 putative dimerization interface [polypeptide binding]; other site 585396010207 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 585396010208 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 585396010209 active site 585396010210 substrate binding site [chemical binding]; other site 585396010211 coenzyme B12 binding site [chemical binding]; other site 585396010212 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 585396010213 B12 binding site [chemical binding]; other site 585396010214 cobalt ligand [ion binding]; other site 585396010215 membrane ATPase/protein kinase; Provisional; Region: PRK09435 585396010216 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 585396010217 Walker A; other site 585396010218 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 585396010219 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585396010220 substrate binding site [chemical binding]; other site 585396010221 oxyanion hole (OAH) forming residues; other site 585396010222 trimer interface [polypeptide binding]; other site 585396010223 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 585396010224 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 585396010225 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 585396010226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396010227 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585396010228 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585396010229 dimerization interface [polypeptide binding]; other site 585396010230 Uncharacterized conserved protein [Function unknown]; Region: COG2968 585396010231 oxidative stress defense protein; Provisional; Region: PRK11087 585396010232 arginine exporter protein; Provisional; Region: PRK09304 585396010233 mechanosensitive channel MscS; Provisional; Region: PRK10334 585396010234 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585396010235 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585396010236 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 585396010237 active site 585396010238 intersubunit interface [polypeptide binding]; other site 585396010239 zinc binding site [ion binding]; other site 585396010240 Na+ binding site [ion binding]; other site 585396010241 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 585396010242 Phosphoglycerate kinase; Region: PGK; pfam00162 585396010243 substrate binding site [chemical binding]; other site 585396010244 hinge regions; other site 585396010245 ADP binding site [chemical binding]; other site 585396010246 catalytic site [active] 585396010247 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 585396010248 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585396010249 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585396010250 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 585396010251 trimer interface [polypeptide binding]; other site 585396010252 putative Zn binding site [ion binding]; other site 585396010253 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 585396010254 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 585396010255 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 585396010256 Walker A/P-loop; other site 585396010257 ATP binding site [chemical binding]; other site 585396010258 Q-loop/lid; other site 585396010259 ABC transporter signature motif; other site 585396010260 Walker B; other site 585396010261 D-loop; other site 585396010262 H-loop/switch region; other site 585396010263 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 585396010264 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 585396010265 Walker A/P-loop; other site 585396010266 ATP binding site [chemical binding]; other site 585396010267 Q-loop/lid; other site 585396010268 ABC transporter signature motif; other site 585396010269 Walker B; other site 585396010270 D-loop; other site 585396010271 H-loop/switch region; other site 585396010272 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 585396010273 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 585396010274 active site 585396010275 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 585396010276 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 585396010277 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 585396010278 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 585396010279 putative active site [active] 585396010280 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 585396010281 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585396010282 putative NAD(P) binding site [chemical binding]; other site 585396010283 catalytic Zn binding site [ion binding]; other site 585396010284 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 585396010285 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 585396010286 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 585396010287 active site 585396010288 P-loop; other site 585396010289 phosphorylation site [posttranslational modification] 585396010290 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585396010291 active site 585396010292 phosphorylation site [posttranslational modification] 585396010293 transketolase; Reviewed; Region: PRK12753 585396010294 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 585396010295 TPP-binding site [chemical binding]; other site 585396010296 dimer interface [polypeptide binding]; other site 585396010297 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585396010298 PYR/PP interface [polypeptide binding]; other site 585396010299 dimer interface [polypeptide binding]; other site 585396010300 TPP binding site [chemical binding]; other site 585396010301 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585396010302 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 585396010303 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 585396010304 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 585396010305 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 585396010306 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 585396010307 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 585396010308 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585396010309 active site 585396010310 phosphorylation site [posttranslational modification] 585396010311 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585396010312 active pocket/dimerization site; other site 585396010313 active site 585396010314 phosphorylation site [posttranslational modification] 585396010315 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 585396010316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396010317 Walker A motif; other site 585396010318 ATP binding site [chemical binding]; other site 585396010319 Walker B motif; other site 585396010320 arginine finger; other site 585396010321 Transcriptional antiterminator [Transcription]; Region: COG3933 585396010322 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 585396010323 active site 585396010324 active pocket/dimerization site; other site 585396010325 phosphorylation site [posttranslational modification] 585396010326 PRD domain; Region: PRD; pfam00874 585396010327 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 585396010328 agmatinase; Region: agmatinase; TIGR01230 585396010329 oligomer interface [polypeptide binding]; other site 585396010330 putative active site [active] 585396010331 Mn binding site [ion binding]; other site 585396010332 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 585396010333 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 585396010334 dimer interface [polypeptide binding]; other site 585396010335 active site 585396010336 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585396010337 catalytic residues [active] 585396010338 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 585396010339 Virulence promoting factor; Region: YqgB; pfam11036 585396010340 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 585396010341 S-adenosylmethionine synthetase; Validated; Region: PRK05250 585396010342 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 585396010343 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 585396010344 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 585396010345 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 585396010346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396010347 putative substrate translocation pore; other site 585396010348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396010349 hypothetical protein; Provisional; Region: PRK04860 585396010350 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 585396010351 DNA-specific endonuclease I; Provisional; Region: PRK15137 585396010352 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 585396010353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 585396010354 RNA methyltransferase, RsmE family; Region: TIGR00046 585396010355 glutathione synthetase; Provisional; Region: PRK05246 585396010356 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 585396010357 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 585396010358 hypothetical protein; Validated; Region: PRK00228 585396010359 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 585396010360 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 585396010361 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 585396010362 Walker A motif; other site 585396010363 ATP binding site [chemical binding]; other site 585396010364 Walker B motif; other site 585396010365 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 585396010366 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585396010367 catalytic residue [active] 585396010368 YGGT family; Region: YGGT; pfam02325 585396010369 YGGT family; Region: YGGT; pfam02325 585396010370 hypothetical protein; Validated; Region: PRK05090 585396010371 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 585396010372 active site 585396010373 dimerization interface [polypeptide binding]; other site 585396010374 HemN family oxidoreductase; Provisional; Region: PRK05660 585396010375 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396010376 FeS/SAM binding site; other site 585396010377 HemN C-terminal domain; Region: HemN_C; pfam06969 585396010378 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585396010379 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 585396010380 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 585396010381 DctM-like transporters; Region: DctM; pfam06808 585396010382 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 585396010383 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 585396010384 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 585396010385 homodimer interface [polypeptide binding]; other site 585396010386 active site 585396010387 hypothetical protein; Provisional; Region: PRK10626 585396010388 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 585396010389 hypothetical protein; Provisional; Region: PRK11702 585396010390 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 585396010391 adenine DNA glycosylase; Provisional; Region: PRK10880 585396010392 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585396010393 minor groove reading motif; other site 585396010394 helix-hairpin-helix signature motif; other site 585396010395 substrate binding pocket [chemical binding]; other site 585396010396 active site 585396010397 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 585396010398 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 585396010399 DNA binding and oxoG recognition site [nucleotide binding] 585396010400 oxidative damage protection protein; Provisional; Region: PRK05408 585396010401 murein transglycosylase C; Provisional; Region: mltC; PRK11671 585396010402 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 585396010403 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585396010404 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585396010405 catalytic residue [active] 585396010406 nucleoside transporter; Region: 2A0110; TIGR00889 585396010407 ornithine decarboxylase; Provisional; Region: PRK13578 585396010408 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585396010409 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585396010410 homodimer interface [polypeptide binding]; other site 585396010411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396010412 catalytic residue [active] 585396010413 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585396010414 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 585396010415 Integrative element ECO111_IE05, LEE 585396010416 integrase; Provisional; Region: PRK09692 585396010417 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585396010418 active site 585396010419 Int/Topo IB signature motif; other site 585396010420 Integrative element ECO111_IE05; predicted protein Orf3 in insertion sequence ISEc8, C-terminal fragment 585396010421 Transposase; Region: HTH_Tnp_1; cl17663 585396010422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396010423 putative transposase OrfB; Reviewed; Region: PHA02517 585396010424 HTH-like domain; Region: HTH_21; pfam13276 585396010425 Integrase core domain; Region: rve; pfam00665 585396010426 Integrase core domain; Region: rve_3; pfam13683 585396010427 Integrative element ECO111_IE05; predicted transposase of insertion sequence IS608, C-terminal fragment 585396010428 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 585396010429 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 585396010430 type III secretion system protein; Provisional; Region: PRK15384; cl14665 585396010431 Integrative element ECO111_IE05; predicted transposase of insertion sequence IS630, partial 585396010432 Integrative element ECO111_IE05; predicted transposase of insertion sequence IS630, partial 585396010433 Integrative element ECO111_IE05; putative transposase InsAB' of insertion sequence IS2, C-terminal fragment 585396010434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 585396010435 SdiA-regulated; Region: SdiA-regulated; cd09971 585396010436 putative active site [active] 585396010437 EspG protein; Region: EspG; pfam06872 585396010438 putative transposase OrfB; Reviewed; Region: PHA02517 585396010439 HTH-like domain; Region: HTH_21; pfam13276 585396010440 Integrase core domain; Region: rve; pfam00665 585396010441 Integrase core domain; Region: rve_2; pfam13333 585396010442 Transposase; Region: HTH_Tnp_1; cl17663 585396010443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396010444 type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498 585396010445 type III secretion apparatus needle protein; Region: III_needle; TIGR02105 585396010446 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 585396010447 Enterobacterial EspB protein; Region: EspB; pfam05802 585396010448 Uncharacterized conserved protein [Function unknown]; Region: COG5613 585396010449 EspA-like secreted protein; Region: EspA; pfam03433 585396010450 HrpJ-like domain; Region: HrpJ; cl15454 585396010451 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 585396010452 type III secretion system protein SsaD; Provisional; Region: PRK15367 585396010453 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 585396010454 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585396010455 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 585396010456 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585396010457 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585396010458 Intimin C-type lectin domain; Region: Intimin_C; pfam07979 585396010459 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 585396010460 Translocated intimin receptor (Tir) N-terminus; Region: Tir_receptor_N; pfam07490 585396010461 Translocated intimin receptor (Tir) intimin-binding domain; Region: Tir_receptor_M; pfam03549 585396010462 Translocated intimin receptor (Tir) C-terminus; Region: Tir_receptor_C; pfam07489 585396010463 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 585396010464 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 585396010465 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 585396010466 Protein of unknown function (DUF1106); Region: DUF1106; pfam06523 585396010467 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 585396010468 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 585396010469 Walker A motif/ATP binding site; other site 585396010470 Walker B motif; other site 585396010471 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 585396010472 FHIPEP family; Region: FHIPEP; pfam00771 585396010473 SepZ; Region: SepZ; pfam06066 585396010474 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 585396010475 outer membrane secretin SsaC; Provisional; Region: PRK15346 585396010476 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585396010477 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 585396010478 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 585396010479 Tetratricopeptide repeat; Region: TPR_3; pfam07720 585396010480 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 585396010481 negative regulator GrlR; Provisional; Region: PRK14051 585396010482 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 585396010483 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585396010484 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585396010485 catalytic residue [active] 585396010486 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 585396010487 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 585396010488 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 585396010489 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 585396010490 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 585396010491 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 585396010492 Type III secretion system filament chaperone CesA; Region: CesA; pfam11439 585396010493 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 585396010494 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 585396010495 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585396010496 IS2 transposase TnpB; Reviewed; Region: PRK09409 585396010497 HTH-like domain; Region: HTH_21; pfam13276 585396010498 Integrase core domain; Region: rve; pfam00665 585396010499 Integrase core domain; Region: rve_3; pfam13683 585396010500 Integrative element ECO111_IE05; putative repressor protein InsA of insertion sequence IS2, C-terminal fragment 585396010501 Transposase; Region: HTH_Tnp_1; cl17663 585396010502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396010503 putative transposase OrfB; Reviewed; Region: PHA02517 585396010504 HTH-like domain; Region: HTH_21; pfam13276 585396010505 Integrase core domain; Region: rve; pfam00665 585396010506 Integrase core domain; Region: rve_3; pfam13683 585396010507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396010508 Transposase; Region: HTH_Tnp_1; cl17663 585396010509 HTH-like domain; Region: HTH_21; pfam13276 585396010510 Integrase core domain; Region: rve; pfam00665 585396010511 DDE domain; Region: DDE_Tnp_IS240; pfam13610 585396010512 Integrase core domain; Region: rve_3; pfam13683 585396010513 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 585396010514 Methyltransferase domain; Region: Methyltransf_27; pfam13708 585396010515 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 585396010516 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 585396010517 GspL-like protein; Provisional; Region: PRK09662 585396010518 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 585396010519 type II secretion system protein J; Region: gspJ; TIGR01711 585396010520 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 585396010521 type II secretion system protein I; Region: gspI; TIGR01707 585396010522 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 585396010523 Type II transport protein GspH; Region: GspH; pfam12019 585396010524 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 585396010525 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 585396010526 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 585396010527 type II secretion system protein F; Region: GspF; TIGR02120 585396010528 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585396010529 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585396010530 type II secretion system protein E; Region: type_II_gspE; TIGR02533 585396010531 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 585396010532 Walker A motif; other site 585396010533 ATP binding site [chemical binding]; other site 585396010534 Walker B motif; other site 585396010535 type II secretion system protein D; Region: type_II_gspD; TIGR02517 585396010536 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585396010537 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585396010538 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585396010539 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 585396010540 putative type II secretion protein GspC; Provisional; Region: PRK09681 585396010541 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 585396010542 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585396010543 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 585396010544 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 585396010545 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 585396010546 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 585396010547 Peptidase M60-like family; Region: M60-like; pfam13402 585396010548 glycolate transporter; Provisional; Region: PRK09695 585396010549 L-lactate permease; Region: Lactate_perm; cl00701 585396010550 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 585396010551 active site 585396010552 hypothetical protein; Provisional; Region: PRK09732 585396010553 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 585396010554 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585396010555 Cysteine-rich domain; Region: CCG; pfam02754 585396010556 Cysteine-rich domain; Region: CCG; pfam02754 585396010557 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 585396010558 FAD binding domain; Region: FAD_binding_4; pfam01565 585396010559 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 585396010560 FAD binding domain; Region: FAD_binding_4; pfam01565 585396010561 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 585396010562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396010563 DNA-binding site [nucleotide binding]; DNA binding site 585396010564 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585396010565 acyl-CoA synthetase; Validated; Region: PRK09192 585396010566 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 585396010567 acyl-activating enzyme (AAE) consensus motif; other site 585396010568 active site 585396010569 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585396010570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585396010571 NAD(P) binding site [chemical binding]; other site 585396010572 active site 585396010573 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585396010574 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585396010575 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 585396010576 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585396010577 catalytic residue [active] 585396010578 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 585396010579 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585396010580 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585396010581 Predicted permeases [General function prediction only]; Region: COG0795 585396010582 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 585396010583 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 585396010584 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 585396010585 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 585396010586 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 585396010587 active site 585396010588 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 585396010589 TMP-binding site; other site 585396010590 ATP-binding site [chemical binding]; other site 585396010591 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 585396010592 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 585396010593 TMP-binding site; other site 585396010594 ATP-binding site [chemical binding]; other site 585396010595 phosphate transporter, C-terminal fragment 585396010596 phosphate transporter, N-terminal fragment 585396010597 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 585396010598 CHAP domain; Region: CHAP; pfam05257 585396010599 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585396010600 putative S-transferase; Provisional; Region: PRK11752 585396010601 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 585396010602 C-terminal domain interface [polypeptide binding]; other site 585396010603 GSH binding site (G-site) [chemical binding]; other site 585396010604 dimer interface [polypeptide binding]; other site 585396010605 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 585396010606 dimer interface [polypeptide binding]; other site 585396010607 N-terminal domain interface [polypeptide binding]; other site 585396010608 active site 585396010609 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 585396010610 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 585396010611 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 585396010612 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 585396010613 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 585396010614 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 585396010615 putative substrate-binding site; other site 585396010616 nickel binding site [ion binding]; other site 585396010617 hydrogenase 2 large subunit; Provisional; Region: PRK10467 585396010618 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 585396010619 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 585396010620 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 585396010621 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 585396010622 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585396010623 hydrogenase 2 small subunit; Provisional; Region: PRK10468 585396010624 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585396010625 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 585396010626 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 585396010627 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 585396010628 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585396010629 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585396010630 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585396010631 active site 585396010632 catalytic tetrad [active] 585396010633 hypothetical protein; Provisional; Region: PRK05208 585396010634 oxidoreductase; Provisional; Region: PRK07985 585396010635 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 585396010636 NAD binding site [chemical binding]; other site 585396010637 metal binding site [ion binding]; metal-binding site 585396010638 active site 585396010639 biopolymer transport protein ExbD; Provisional; Region: PRK11267 585396010640 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 585396010641 biopolymer transport protein ExbB; Provisional; Region: PRK10414 585396010642 cystathionine beta-lyase; Provisional; Region: PRK08114 585396010643 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 585396010644 homodimer interface [polypeptide binding]; other site 585396010645 substrate-cofactor binding pocket; other site 585396010646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396010647 catalytic residue [active] 585396010648 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585396010649 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 585396010650 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 585396010651 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585396010652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396010653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396010654 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 585396010655 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 585396010656 dimer interface [polypeptide binding]; other site 585396010657 active site 585396010658 metal binding site [ion binding]; metal-binding site 585396010659 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585396010660 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585396010661 active site 585396010662 catalytic tetrad [active] 585396010663 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 585396010664 putative outer membrane lipoprotein; Provisional; Region: PRK09973 585396010665 hypothetical protein; Provisional; Region: PRK01254 585396010666 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 585396010667 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 585396010668 FtsI repressor; Provisional; Region: PRK10883 585396010669 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 585396010670 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 585396010671 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 585396010672 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 585396010673 putative acyl-acceptor binding pocket; other site 585396010674 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 585396010675 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 585396010676 CAP-like domain; other site 585396010677 active site 585396010678 primary dimer interface [polypeptide binding]; other site 585396010679 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585396010680 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 585396010681 TIGR00156 family protein; Region: TIGR00156 585396010682 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 585396010683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396010684 active site 585396010685 phosphorylation site [posttranslational modification] 585396010686 intermolecular recognition site; other site 585396010687 dimerization interface [polypeptide binding]; other site 585396010688 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396010689 DNA binding site [nucleotide binding] 585396010690 sensor protein QseC; Provisional; Region: PRK10337 585396010691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396010692 dimer interface [polypeptide binding]; other site 585396010693 phosphorylation site [posttranslational modification] 585396010694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396010695 ATP binding site [chemical binding]; other site 585396010696 Mg2+ binding site [ion binding]; other site 585396010697 G-X-G motif; other site 585396010698 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 585396010699 Uncharacterized conserved protein [Function unknown]; Region: COG1359 585396010700 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 585396010701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396010702 ATP binding site [chemical binding]; other site 585396010703 Mg2+ binding site [ion binding]; other site 585396010704 G-X-G motif; other site 585396010705 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 585396010706 anchoring element; other site 585396010707 dimer interface [polypeptide binding]; other site 585396010708 ATP binding site [chemical binding]; other site 585396010709 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 585396010710 active site 585396010711 metal binding site [ion binding]; metal-binding site 585396010712 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 585396010713 esterase YqiA; Provisional; Region: PRK11071 585396010714 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 585396010715 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 585396010716 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585396010717 active site 585396010718 metal binding site [ion binding]; metal-binding site 585396010719 hexamer interface [polypeptide binding]; other site 585396010720 putative dehydrogenase; Provisional; Region: PRK11039 585396010721 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 585396010722 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585396010723 dimer interface [polypeptide binding]; other site 585396010724 ADP-ribose binding site [chemical binding]; other site 585396010725 active site 585396010726 nudix motif; other site 585396010727 metal binding site [ion binding]; metal-binding site 585396010728 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 585396010729 hypothetical protein; Provisional; Region: PRK11653 585396010730 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585396010731 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 585396010732 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 585396010733 putative active site [active] 585396010734 metal binding site [ion binding]; metal-binding site 585396010735 zinc transporter ZupT; Provisional; Region: PRK04201 585396010736 ZIP Zinc transporter; Region: Zip; pfam02535 585396010737 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 585396010738 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 585396010739 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 585396010740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 585396010741 putative fimbrial protein; Provisional; Region: PRK09733 585396010742 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585396010743 PapC N-terminal domain; Region: PapC_N; pfam13954 585396010744 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585396010745 PapC C-terminal domain; Region: PapC_C; pfam13953 585396010746 predicted periplasmic pilin chaperone, N-terminal fragment 585396010747 predicted periplasmic pilin chaperone, C-terminal fragment 585396010748 Fimbrial protein; Region: Fimbrial; pfam00419 585396010749 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 585396010750 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 585396010751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 585396010752 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 585396010753 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 585396010754 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 585396010755 putative ribose interaction site [chemical binding]; other site 585396010756 putative ADP binding site [chemical binding]; other site 585396010757 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 585396010758 active site 585396010759 nucleotide binding site [chemical binding]; other site 585396010760 HIGH motif; other site 585396010761 KMSKS motif; other site 585396010762 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 585396010763 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585396010764 metal binding triad; other site 585396010765 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585396010766 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585396010767 metal binding triad; other site 585396010768 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585396010769 Uncharacterized conserved protein [Function unknown]; Region: COG3025 585396010770 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 585396010771 putative active site [active] 585396010772 putative metal binding residues [ion binding]; other site 585396010773 signature motif; other site 585396010774 putative triphosphate binding site [ion binding]; other site 585396010775 CHAD domain; Region: CHAD; pfam05235 585396010776 SH3 domain-containing protein; Provisional; Region: PRK10884 585396010777 Bacterial SH3 domain homologues; Region: SH3b; smart00287 585396010778 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 585396010779 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 585396010780 active site 585396010781 NTP binding site [chemical binding]; other site 585396010782 metal binding triad [ion binding]; metal-binding site 585396010783 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 585396010784 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585396010785 Zn2+ binding site [ion binding]; other site 585396010786 Mg2+ binding site [ion binding]; other site 585396010787 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 585396010788 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 585396010789 homooctamer interface [polypeptide binding]; other site 585396010790 active site 585396010791 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 585396010792 transcriptional activator TtdR; Provisional; Region: PRK09801 585396010793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396010794 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 585396010795 putative effector binding pocket; other site 585396010796 putative dimerization interface [polypeptide binding]; other site 585396010797 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 585396010798 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 585396010799 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585396010800 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585396010801 transmembrane helices; other site 585396010802 UGMP family protein; Validated; Region: PRK09604 585396010803 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 585396010804 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 585396010805 DNA primase; Validated; Region: dnaG; PRK05667 585396010806 CHC2 zinc finger; Region: zf-CHC2; pfam01807 585396010807 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 585396010808 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 585396010809 active site 585396010810 metal binding site [ion binding]; metal-binding site 585396010811 interdomain interaction site; other site 585396010812 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 585396010813 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 585396010814 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 585396010815 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 585396010816 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 585396010817 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 585396010818 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585396010819 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585396010820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585396010821 DNA binding residues [nucleotide binding] 585396010822 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 585396010823 active site 585396010824 SUMO-1 interface [polypeptide binding]; other site 585396010825 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 585396010826 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 585396010827 FAD binding pocket [chemical binding]; other site 585396010828 FAD binding motif [chemical binding]; other site 585396010829 phosphate binding motif [ion binding]; other site 585396010830 NAD binding pocket [chemical binding]; other site 585396010831 Predicted transcriptional regulators [Transcription]; Region: COG1695 585396010832 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 585396010833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585396010834 PAS fold; Region: PAS_3; pfam08447 585396010835 putative active site [active] 585396010836 heme pocket [chemical binding]; other site 585396010837 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 585396010838 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 585396010839 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585396010840 dimer interface [polypeptide binding]; other site 585396010841 putative CheW interface [polypeptide binding]; other site 585396010842 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 585396010843 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585396010844 inhibitor-cofactor binding pocket; inhibition site 585396010845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396010846 catalytic residue [active] 585396010847 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 585396010848 dimer interface [polypeptide binding]; other site 585396010849 putative tRNA-binding site [nucleotide binding]; other site 585396010850 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 585396010851 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396010852 DNA binding site [nucleotide binding] 585396010853 domain linker motif; other site 585396010854 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 585396010855 putative dimerization interface [polypeptide binding]; other site 585396010856 putative ligand binding site [chemical binding]; other site 585396010857 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 585396010858 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 585396010859 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 585396010860 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 585396010861 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 585396010862 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 585396010863 inner membrane transporter YjeM; Provisional; Region: PRK15238 585396010864 alpha-glucosidase; Provisional; Region: PRK10137 585396010865 Protein of unknown function, DUF608; Region: DUF608; pfam04685 585396010866 Trehalase; Region: Trehalase; cl17346 585396010867 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 585396010868 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 585396010869 active site 585396010870 FMN binding site [chemical binding]; other site 585396010871 2,4-decadienoyl-CoA binding site; other site 585396010872 catalytic residue [active] 585396010873 4Fe-4S cluster binding site [ion binding]; other site 585396010874 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 585396010875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396010876 non-specific DNA binding site [nucleotide binding]; other site 585396010877 salt bridge; other site 585396010878 sequence-specific DNA binding site [nucleotide binding]; other site 585396010879 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 585396010880 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 585396010881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396010882 S-adenosylmethionine binding site [chemical binding]; other site 585396010883 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 585396010884 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585396010885 putative active site [active] 585396010886 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585396010887 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585396010888 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 585396010889 serine/threonine transporter SstT; Provisional; Region: PRK13628 585396010890 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585396010891 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 585396010892 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 585396010893 galactarate dehydratase; Region: galactar-dH20; TIGR03248 585396010894 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 585396010895 Glucuronate isomerase; Region: UxaC; pfam02614 585396010896 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 585396010897 D-galactonate transporter; Region: 2A0114; TIGR00893 585396010898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396010899 putative substrate translocation pore; other site 585396010900 CblD like pilus biogenesis initiator; Region: CblD; cl06460 585396010901 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 585396010902 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585396010903 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 585396010904 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585396010905 putative fimbrial protein TcfA; Provisional; Region: PRK15308 585396010906 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 585396010907 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396010908 DNA-binding site [nucleotide binding]; DNA binding site 585396010909 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585396010910 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585396010911 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 585396010912 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 585396010913 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 585396010914 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 585396010915 Predicted membrane protein [Function unknown]; Region: COG5393 585396010916 YqjK-like protein; Region: YqjK; pfam13997 585396010917 Predicted membrane protein [Function unknown]; Region: COG2259 585396010918 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 585396010919 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 585396010920 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 585396010921 putative dimer interface [polypeptide binding]; other site 585396010922 N-terminal domain interface [polypeptide binding]; other site 585396010923 putative substrate binding pocket (H-site) [chemical binding]; other site 585396010924 Predicted membrane protein [Function unknown]; Region: COG3152 585396010925 Protein of unknown function (DUF805); Region: DUF805; pfam05656 585396010926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396010927 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585396010928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585396010929 dimerization interface [polypeptide binding]; other site 585396010930 Pirin-related protein [General function prediction only]; Region: COG1741 585396010931 Pirin; Region: Pirin; pfam02678 585396010932 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 585396010933 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585396010934 serine transporter; Region: stp; TIGR00814 585396010935 L-serine dehydratase TdcG; Provisional; Region: PRK15040 585396010936 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585396010937 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585396010938 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585396010939 homotrimer interaction site [polypeptide binding]; other site 585396010940 putative active site [active] 585396010941 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 585396010942 Pyruvate formate lyase 1; Region: PFL1; cd01678 585396010943 coenzyme A binding site [chemical binding]; other site 585396010944 active site 585396010945 catalytic residues [active] 585396010946 glycine loop; other site 585396010947 propionate/acetate kinase; Provisional; Region: PRK12379 585396010948 Acetokinase family; Region: Acetate_kinase; cl17229 585396010949 threonine/serine transporter TdcC; Provisional; Region: PRK13629 585396010950 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585396010951 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 585396010952 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 585396010953 tetramer interface [polypeptide binding]; other site 585396010954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396010955 catalytic residue [active] 585396010956 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 585396010957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396010958 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 585396010959 putative substrate binding pocket [chemical binding]; other site 585396010960 putative dimerization interface [polypeptide binding]; other site 585396010961 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 585396010962 hypothetical protein; Provisional; Region: PRK09716 585396010963 glycerate kinase I; Provisional; Region: PRK10342 585396010964 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 585396010965 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585396010966 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 585396010967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396010968 D-galactonate transporter; Region: 2A0114; TIGR00893 585396010969 putative substrate translocation pore; other site 585396010970 galactarate dehydratase; Region: galactar-dH20; TIGR03248 585396010971 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 585396010972 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 585396010973 putative regulator PrlF; Provisional; Region: PRK09974 585396010974 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 585396010975 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 585396010976 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 585396010977 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585396010978 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585396010979 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 585396010980 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585396010981 active site 585396010982 phosphorylation site [posttranslational modification] 585396010983 N-acetylgalactosamine-specific enzyme IIC component of PTS, fragment 585396010984 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 585396010985 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585396010986 active pocket/dimerization site; other site 585396010987 active site 585396010988 phosphorylation site [posttranslational modification] 585396010989 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 585396010990 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 585396010991 active site 585396010992 dimer interface [polypeptide binding]; other site 585396010993 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 585396010994 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 585396010995 dimer interface [polypeptide binding]; other site 585396010996 active site 585396010997 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 585396010998 putative active site [active] 585396010999 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 585396011000 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585396011001 active site 585396011002 intersubunit interface [polypeptide binding]; other site 585396011003 zinc binding site [ion binding]; other site 585396011004 Na+ binding site [ion binding]; other site 585396011005 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585396011006 active site 585396011007 phosphorylation site [posttranslational modification] 585396011008 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 585396011009 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 585396011010 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585396011011 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585396011012 active site 585396011013 trimer interface [polypeptide binding]; other site 585396011014 allosteric site; other site 585396011015 active site lid [active] 585396011016 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585396011017 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585396011018 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585396011019 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585396011020 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585396011021 PapC N-terminal domain; Region: PapC_N; pfam13954 585396011022 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585396011023 PapC C-terminal domain; Region: PapC_C; pfam13953 585396011024 Fimbrial protein; Region: Fimbrial; pfam00419 585396011025 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 585396011026 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 585396011027 putative SAM binding site [chemical binding]; other site 585396011028 putative homodimer interface [polypeptide binding]; other site 585396011029 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 585396011030 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 585396011031 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 585396011032 putative ligand binding site [chemical binding]; other site 585396011033 TIGR00252 family protein; Region: TIGR00252 585396011034 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 585396011035 dimer interface [polypeptide binding]; other site 585396011036 active site 585396011037 outer membrane lipoprotein; Provisional; Region: PRK11023 585396011038 BON domain; Region: BON; pfam04972 585396011039 BON domain; Region: BON; pfam04972 585396011040 Predicted permease; Region: DUF318; pfam03773 585396011041 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 585396011042 NADH(P)-binding; Region: NAD_binding_10; pfam13460 585396011043 NAD binding site [chemical binding]; other site 585396011044 active site 585396011045 intracellular protease, PfpI family; Region: PfpI; TIGR01382 585396011046 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 585396011047 proposed catalytic triad [active] 585396011048 conserved cys residue [active] 585396011049 hypothetical protein; Provisional; Region: PRK03467 585396011050 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 585396011051 GIY-YIG motif/motif A; other site 585396011052 putative active site [active] 585396011053 putative metal binding site [ion binding]; other site 585396011054 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 585396011055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396011056 Coenzyme A binding pocket [chemical binding]; other site 585396011057 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 585396011058 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585396011059 Peptidase family U32; Region: Peptidase_U32; pfam01136 585396011060 putative protease; Provisional; Region: PRK15447 585396011061 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585396011062 hypothetical protein; Provisional; Region: PRK10508 585396011063 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 585396011064 tryptophan permease; Provisional; Region: PRK10483 585396011065 aromatic amino acid transport protein; Region: araaP; TIGR00837 585396011066 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 585396011067 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585396011068 ATP binding site [chemical binding]; other site 585396011069 Mg++ binding site [ion binding]; other site 585396011070 motif III; other site 585396011071 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396011072 nucleotide binding region [chemical binding]; other site 585396011073 ATP-binding site [chemical binding]; other site 585396011074 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 585396011075 putative RNA binding site [nucleotide binding]; other site 585396011076 lipoprotein NlpI; Provisional; Region: PRK11189 585396011077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585396011078 binding surface 585396011079 TPR motif; other site 585396011080 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 585396011081 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 585396011082 RNase E interface [polypeptide binding]; other site 585396011083 trimer interface [polypeptide binding]; other site 585396011084 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 585396011085 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 585396011086 RNase E interface [polypeptide binding]; other site 585396011087 trimer interface [polypeptide binding]; other site 585396011088 active site 585396011089 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 585396011090 putative nucleic acid binding region [nucleotide binding]; other site 585396011091 G-X-X-G motif; other site 585396011092 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 585396011093 RNA binding site [nucleotide binding]; other site 585396011094 domain interface; other site 585396011095 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 585396011096 16S/18S rRNA binding site [nucleotide binding]; other site 585396011097 S13e-L30e interaction site [polypeptide binding]; other site 585396011098 25S rRNA binding site [nucleotide binding]; other site 585396011099 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 585396011100 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 585396011101 RNA binding site [nucleotide binding]; other site 585396011102 active site 585396011103 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 585396011104 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 585396011105 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 585396011106 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 585396011107 translation initiation factor IF-2; Region: IF-2; TIGR00487 585396011108 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 585396011109 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 585396011110 G1 box; other site 585396011111 putative GEF interaction site [polypeptide binding]; other site 585396011112 GTP/Mg2+ binding site [chemical binding]; other site 585396011113 Switch I region; other site 585396011114 G2 box; other site 585396011115 G3 box; other site 585396011116 Switch II region; other site 585396011117 G4 box; other site 585396011118 G5 box; other site 585396011119 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 585396011120 Translation-initiation factor 2; Region: IF-2; pfam11987 585396011121 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 585396011122 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 585396011123 NusA N-terminal domain; Region: NusA_N; pfam08529 585396011124 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 585396011125 RNA binding site [nucleotide binding]; other site 585396011126 homodimer interface [polypeptide binding]; other site 585396011127 NusA-like KH domain; Region: KH_5; pfam13184 585396011128 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 585396011129 G-X-X-G motif; other site 585396011130 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 585396011131 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 585396011132 ribosome maturation protein RimP; Reviewed; Region: PRK00092 585396011133 hypothetical protein; Provisional; Region: PRK14641 585396011134 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 585396011135 putative oligomer interface [polypeptide binding]; other site 585396011136 putative RNA binding site [nucleotide binding]; other site 585396011137 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 585396011138 ANP binding site [chemical binding]; other site 585396011139 Substrate Binding Site II [chemical binding]; other site 585396011140 Substrate Binding Site I [chemical binding]; other site 585396011141 predicted hydrolase, inner membrane, C-terminal fragment 585396011142 putative transposase OrfB; Reviewed; Region: PHA02517 585396011143 HTH-like domain; Region: HTH_21; pfam13276 585396011144 Integrase core domain; Region: rve; pfam00665 585396011145 Integrase core domain; Region: rve_3; pfam13683 585396011146 Transposase; Region: HTH_Tnp_1; cl17663 585396011147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396011148 predicted hydrolase, inner membrane, N-terminal fragment 585396011149 Preprotein translocase SecG subunit; Region: SecG; pfam03840 585396011150 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 585396011151 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 585396011152 active site 585396011153 substrate binding site [chemical binding]; other site 585396011154 metal binding site [ion binding]; metal-binding site 585396011155 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 585396011156 dihydropteroate synthase; Region: DHPS; TIGR01496 585396011157 substrate binding pocket [chemical binding]; other site 585396011158 dimer interface [polypeptide binding]; other site 585396011159 inhibitor binding site; inhibition site 585396011160 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 585396011161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396011162 Walker A motif; other site 585396011163 ATP binding site [chemical binding]; other site 585396011164 Walker B motif; other site 585396011165 arginine finger; other site 585396011166 Peptidase family M41; Region: Peptidase_M41; pfam01434 585396011167 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 585396011168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396011169 S-adenosylmethionine binding site [chemical binding]; other site 585396011170 RNA-binding protein YhbY; Provisional; Region: PRK10343 585396011171 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 585396011172 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 585396011173 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585396011174 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 585396011175 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 585396011176 GTPase CgtA; Reviewed; Region: obgE; PRK12298 585396011177 GTP1/OBG; Region: GTP1_OBG; pfam01018 585396011178 Obg GTPase; Region: Obg; cd01898 585396011179 G1 box; other site 585396011180 GTP/Mg2+ binding site [chemical binding]; other site 585396011181 Switch I region; other site 585396011182 G2 box; other site 585396011183 G3 box; other site 585396011184 Switch II region; other site 585396011185 G4 box; other site 585396011186 G5 box; other site 585396011187 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 585396011188 EamA-like transporter family; Region: EamA; pfam00892 585396011189 EamA-like transporter family; Region: EamA; pfam00892 585396011190 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 585396011191 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 585396011192 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 585396011193 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 585396011194 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 585396011195 substrate binding pocket [chemical binding]; other site 585396011196 chain length determination region; other site 585396011197 substrate-Mg2+ binding site; other site 585396011198 catalytic residues [active] 585396011199 aspartate-rich region 1; other site 585396011200 active site lid residues [active] 585396011201 aspartate-rich region 2; other site 585396011202 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 585396011203 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 585396011204 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 585396011205 hinge; other site 585396011206 active site 585396011207 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 585396011208 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 585396011209 anti sigma factor interaction site; other site 585396011210 regulatory phosphorylation site [posttranslational modification]; other site 585396011211 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 585396011212 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 585396011213 mce related protein; Region: MCE; pfam02470 585396011214 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 585396011215 conserved hypothetical integral membrane protein; Region: TIGR00056 585396011216 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 585396011217 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 585396011218 Walker A/P-loop; other site 585396011219 ATP binding site [chemical binding]; other site 585396011220 Q-loop/lid; other site 585396011221 ABC transporter signature motif; other site 585396011222 Walker B; other site 585396011223 D-loop; other site 585396011224 H-loop/switch region; other site 585396011225 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 585396011226 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585396011227 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585396011228 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 585396011229 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 585396011230 putative active site [active] 585396011231 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 585396011232 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 585396011233 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 585396011234 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 585396011235 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 585396011236 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 585396011237 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 585396011238 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 585396011239 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 585396011240 Walker A/P-loop; other site 585396011241 ATP binding site [chemical binding]; other site 585396011242 Q-loop/lid; other site 585396011243 ABC transporter signature motif; other site 585396011244 Walker B; other site 585396011245 D-loop; other site 585396011246 H-loop/switch region; other site 585396011247 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 585396011248 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 585396011249 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 585396011250 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 585396011251 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 585396011252 30S subunit binding site; other site 585396011253 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585396011254 active site 585396011255 phosphorylation site [posttranslational modification] 585396011256 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 585396011257 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585396011258 dimerization domain swap beta strand [polypeptide binding]; other site 585396011259 regulatory protein interface [polypeptide binding]; other site 585396011260 active site 585396011261 regulatory phosphorylation site [posttranslational modification]; other site 585396011262 hypothetical protein; Provisional; Region: PRK10345 585396011263 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 585396011264 Transglycosylase; Region: Transgly; cl17702 585396011265 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 585396011266 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 585396011267 conserved cys residue [active] 585396011268 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 585396011269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585396011270 putative active site [active] 585396011271 heme pocket [chemical binding]; other site 585396011272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396011273 dimer interface [polypeptide binding]; other site 585396011274 phosphorylation site [posttranslational modification] 585396011275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396011276 ATP binding site [chemical binding]; other site 585396011277 Mg2+ binding site [ion binding]; other site 585396011278 G-X-G motif; other site 585396011279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396011280 active site 585396011281 phosphorylation site [posttranslational modification] 585396011282 intermolecular recognition site; other site 585396011283 dimerization interface [polypeptide binding]; other site 585396011284 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585396011285 putative binding surface; other site 585396011286 active site 585396011287 radical SAM protein, TIGR01212 family; Region: TIGR01212 585396011288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396011289 FeS/SAM binding site; other site 585396011290 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 585396011291 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 585396011292 active site 585396011293 dimer interface [polypeptide binding]; other site 585396011294 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 585396011295 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 585396011296 active site 585396011297 FMN binding site [chemical binding]; other site 585396011298 substrate binding site [chemical binding]; other site 585396011299 3Fe-4S cluster binding site [ion binding]; other site 585396011300 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 585396011301 domain interface; other site 585396011302 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 585396011303 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585396011304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396011305 conserved predicted protein, N-terminal fragment 585396011306 conserved predicted protein, C-terminal fragment 585396011307 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 585396011308 N-acetylmannosamine kinase; Provisional; Region: PRK05082 585396011309 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585396011310 nucleotide binding site [chemical binding]; other site 585396011311 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585396011312 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 585396011313 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 585396011314 putative active site cavity [active] 585396011315 putative sialic acid transporter; Provisional; Region: PRK03893 585396011316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396011317 putative substrate translocation pore; other site 585396011318 N-acetylneuraminate lyase; Region: nanA; TIGR00683 585396011319 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 585396011320 inhibitor site; inhibition site 585396011321 active site 585396011322 dimer interface [polypeptide binding]; other site 585396011323 catalytic residue [active] 585396011324 transcriptional regulator NanR; Provisional; Region: PRK03837 585396011325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396011326 DNA-binding site [nucleotide binding]; DNA binding site 585396011327 FCD domain; Region: FCD; pfam07729 585396011328 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 585396011329 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 585396011330 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 585396011331 stringent starvation protein A; Provisional; Region: sspA; PRK09481 585396011332 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 585396011333 C-terminal domain interface [polypeptide binding]; other site 585396011334 putative GSH binding site (G-site) [chemical binding]; other site 585396011335 dimer interface [polypeptide binding]; other site 585396011336 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 585396011337 dimer interface [polypeptide binding]; other site 585396011338 N-terminal domain interface [polypeptide binding]; other site 585396011339 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 585396011340 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 585396011341 23S rRNA interface [nucleotide binding]; other site 585396011342 L3 interface [polypeptide binding]; other site 585396011343 Predicted ATPase [General function prediction only]; Region: COG1485 585396011344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 585396011345 hypothetical protein; Provisional; Region: PRK11677 585396011346 serine endoprotease; Provisional; Region: PRK10139 585396011347 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585396011348 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585396011349 protein binding site [polypeptide binding]; other site 585396011350 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585396011351 serine endoprotease; Provisional; Region: PRK10898 585396011352 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585396011353 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585396011354 malate dehydrogenase; Provisional; Region: PRK05086 585396011355 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 585396011356 NAD binding site [chemical binding]; other site 585396011357 dimerization interface [polypeptide binding]; other site 585396011358 Substrate binding site [chemical binding]; other site 585396011359 arginine repressor; Provisional; Region: PRK05066 585396011360 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 585396011361 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 585396011362 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585396011363 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 585396011364 RNAase interaction site [polypeptide binding]; other site 585396011365 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 585396011366 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585396011367 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 585396011368 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396011369 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396011370 efflux system membrane protein; Provisional; Region: PRK11594 585396011371 transcriptional regulator; Provisional; Region: PRK10632 585396011372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396011373 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 585396011374 putative effector binding pocket; other site 585396011375 dimerization interface [polypeptide binding]; other site 585396011376 protease TldD; Provisional; Region: tldD; PRK10735 585396011377 hypothetical protein; Provisional; Region: PRK10899 585396011378 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585396011379 ribonuclease G; Provisional; Region: PRK11712 585396011380 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 585396011381 homodimer interface [polypeptide binding]; other site 585396011382 oligonucleotide binding site [chemical binding]; other site 585396011383 Maf-like protein; Region: Maf; pfam02545 585396011384 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 585396011385 active site 585396011386 dimer interface [polypeptide binding]; other site 585396011387 rod shape-determining protein MreD; Provisional; Region: PRK11060 585396011388 rod shape-determining protein MreC; Region: mreC; TIGR00219 585396011389 rod shape-determining protein MreC; Region: MreC; pfam04085 585396011390 rod shape-determining protein MreB; Provisional; Region: PRK13927 585396011391 MreB and similar proteins; Region: MreB_like; cd10225 585396011392 nucleotide binding site [chemical binding]; other site 585396011393 Mg binding site [ion binding]; other site 585396011394 putative protofilament interaction site [polypeptide binding]; other site 585396011395 RodZ interaction site [polypeptide binding]; other site 585396011396 regulatory protein CsrD; Provisional; Region: PRK11059 585396011397 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396011398 metal binding site [ion binding]; metal-binding site 585396011399 active site 585396011400 I-site; other site 585396011401 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396011402 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 585396011403 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 585396011404 NADP binding site [chemical binding]; other site 585396011405 dimer interface [polypeptide binding]; other site 585396011406 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 585396011407 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 585396011408 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 585396011409 carboxyltransferase (CT) interaction site; other site 585396011410 biotinylation site [posttranslational modification]; other site 585396011411 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 585396011412 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585396011413 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 585396011414 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 585396011415 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 585396011416 active site 585396011417 catalytic residues [active] 585396011418 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585396011419 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 585396011420 substrate binding site [chemical binding]; other site 585396011421 ATP binding site [chemical binding]; other site 585396011422 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585396011423 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585396011424 TM-ABC transporter signature motif; other site 585396011425 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585396011426 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585396011427 Walker A/P-loop; other site 585396011428 ATP binding site [chemical binding]; other site 585396011429 Q-loop/lid; other site 585396011430 ABC transporter signature motif; other site 585396011431 Walker B; other site 585396011432 D-loop; other site 585396011433 H-loop/switch region; other site 585396011434 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585396011435 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 585396011436 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 585396011437 putative ligand binding site [chemical binding]; other site 585396011438 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 585396011439 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585396011440 intersubunit interface [polypeptide binding]; other site 585396011441 active site 585396011442 zinc binding site [ion binding]; other site 585396011443 Na+ binding site [ion binding]; other site 585396011444 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585396011445 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585396011446 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585396011447 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 585396011448 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585396011449 substrate binding site [chemical binding]; other site 585396011450 ATP binding site [chemical binding]; other site 585396011451 hypothetical protein; Provisional; Region: PRK10633 585396011452 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 585396011453 Na binding site [ion binding]; other site 585396011454 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 585396011455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 585396011456 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 585396011457 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585396011458 FMN binding site [chemical binding]; other site 585396011459 active site 585396011460 catalytic residues [active] 585396011461 substrate binding site [chemical binding]; other site 585396011462 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 585396011463 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 585396011464 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585396011465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396011466 DNA methylase; Region: N6_N4_Mtase; pfam01555 585396011467 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 585396011468 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 585396011469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585396011470 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 585396011471 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 585396011472 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396011473 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396011474 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 585396011475 Protein export membrane protein; Region: SecD_SecF; cl14618 585396011476 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 585396011477 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 585396011478 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396011479 substrate binding pocket [chemical binding]; other site 585396011480 membrane-bound complex binding site; other site 585396011481 hinge residues; other site 585396011482 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 585396011483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396011484 conserved gate region; other site 585396011485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396011486 dimer interface [polypeptide binding]; other site 585396011487 conserved gate region; other site 585396011488 putative PBP binding loops; other site 585396011489 ABC-ATPase subunit interface; other site 585396011490 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585396011491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396011492 dimer interface [polypeptide binding]; other site 585396011493 conserved gate region; other site 585396011494 putative PBP binding loops; other site 585396011495 ABC-ATPase subunit interface; other site 585396011496 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 585396011497 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585396011498 Walker A/P-loop; other site 585396011499 ATP binding site [chemical binding]; other site 585396011500 Q-loop/lid; other site 585396011501 ABC transporter signature motif; other site 585396011502 Walker B; other site 585396011503 D-loop; other site 585396011504 H-loop/switch region; other site 585396011505 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 585396011506 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 585396011507 trimer interface [polypeptide binding]; other site 585396011508 putative metal binding site [ion binding]; other site 585396011509 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 585396011510 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 585396011511 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 585396011512 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 585396011513 shikimate binding site; other site 585396011514 NAD(P) binding site [chemical binding]; other site 585396011515 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 585396011516 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585396011517 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 585396011518 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585396011519 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585396011520 hypothetical protein; Validated; Region: PRK03430 585396011521 conserved predicted protein, C-terminal part 585396011522 conserved predicted protein, N-terminal part 585396011523 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 585396011524 active site 585396011525 catalytic residues [active] 585396011526 metal binding site [ion binding]; metal-binding site 585396011527 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 585396011528 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 585396011529 putative active site [active] 585396011530 substrate binding site [chemical binding]; other site 585396011531 putative cosubstrate binding site; other site 585396011532 catalytic site [active] 585396011533 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 585396011534 substrate binding site [chemical binding]; other site 585396011535 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 585396011536 putative RNA binding site [nucleotide binding]; other site 585396011537 16S rRNA methyltransferase B; Provisional; Region: PRK10901 585396011538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396011539 S-adenosylmethionine binding site [chemical binding]; other site 585396011540 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 585396011541 TrkA-N domain; Region: TrkA_N; pfam02254 585396011542 TrkA-C domain; Region: TrkA_C; pfam02080 585396011543 TrkA-N domain; Region: TrkA_N; pfam02254 585396011544 TrkA-C domain; Region: TrkA_C; pfam02080 585396011545 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 585396011546 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 585396011547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 585396011548 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 585396011549 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 585396011550 DNA binding residues [nucleotide binding] 585396011551 dimer interface [polypeptide binding]; other site 585396011552 metal binding site [ion binding]; metal-binding site 585396011553 hypothetical protein; Provisional; Region: PRK10203 585396011554 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 585396011555 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 585396011556 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 585396011557 alphaNTD homodimer interface [polypeptide binding]; other site 585396011558 alphaNTD - beta interaction site [polypeptide binding]; other site 585396011559 alphaNTD - beta' interaction site [polypeptide binding]; other site 585396011560 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 585396011561 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 585396011562 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 585396011563 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585396011564 RNA binding surface [nucleotide binding]; other site 585396011565 30S ribosomal protein S11; Validated; Region: PRK05309 585396011566 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 585396011567 30S ribosomal protein S13; Region: bact_S13; TIGR03631 585396011568 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 585396011569 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 585396011570 SecY translocase; Region: SecY; pfam00344 585396011571 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 585396011572 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 585396011573 23S rRNA binding site [nucleotide binding]; other site 585396011574 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 585396011575 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 585396011576 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 585396011577 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 585396011578 23S rRNA interface [nucleotide binding]; other site 585396011579 5S rRNA interface [nucleotide binding]; other site 585396011580 L27 interface [polypeptide binding]; other site 585396011581 L5 interface [polypeptide binding]; other site 585396011582 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 585396011583 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 585396011584 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 585396011585 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 585396011586 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 585396011587 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 585396011588 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 585396011589 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 585396011590 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 585396011591 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 585396011592 RNA binding site [nucleotide binding]; other site 585396011593 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 585396011594 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 585396011595 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 585396011596 23S rRNA interface [nucleotide binding]; other site 585396011597 putative translocon interaction site; other site 585396011598 signal recognition particle (SRP54) interaction site; other site 585396011599 L23 interface [polypeptide binding]; other site 585396011600 trigger factor interaction site; other site 585396011601 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 585396011602 23S rRNA interface [nucleotide binding]; other site 585396011603 5S rRNA interface [nucleotide binding]; other site 585396011604 putative antibiotic binding site [chemical binding]; other site 585396011605 L25 interface [polypeptide binding]; other site 585396011606 L27 interface [polypeptide binding]; other site 585396011607 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 585396011608 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 585396011609 G-X-X-G motif; other site 585396011610 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 585396011611 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 585396011612 protein-rRNA interface [nucleotide binding]; other site 585396011613 putative translocon binding site; other site 585396011614 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 585396011615 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 585396011616 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 585396011617 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 585396011618 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 585396011619 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 585396011620 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 585396011621 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 585396011622 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 585396011623 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 585396011624 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 585396011625 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 585396011626 heme binding site [chemical binding]; other site 585396011627 ferroxidase pore; other site 585396011628 ferroxidase diiron center [ion binding]; other site 585396011629 regulatory or redox component complexing with Bfr, in iron storage and mobility [bfd], C-terminal fragment 585396011630 elongation factor Tu; Reviewed; Region: PRK00049 585396011631 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 585396011632 G1 box; other site 585396011633 GEF interaction site [polypeptide binding]; other site 585396011634 GTP/Mg2+ binding site [chemical binding]; other site 585396011635 Switch I region; other site 585396011636 G2 box; other site 585396011637 G3 box; other site 585396011638 Switch II region; other site 585396011639 G4 box; other site 585396011640 G5 box; other site 585396011641 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 585396011642 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 585396011643 Antibiotic Binding Site [chemical binding]; other site 585396011644 elongation factor G; Reviewed; Region: PRK00007 585396011645 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 585396011646 G1 box; other site 585396011647 putative GEF interaction site [polypeptide binding]; other site 585396011648 GTP/Mg2+ binding site [chemical binding]; other site 585396011649 Switch I region; other site 585396011650 G2 box; other site 585396011651 G3 box; other site 585396011652 Switch II region; other site 585396011653 G4 box; other site 585396011654 G5 box; other site 585396011655 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 585396011656 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 585396011657 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 585396011658 30S ribosomal protein S7; Validated; Region: PRK05302 585396011659 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 585396011660 S17 interaction site [polypeptide binding]; other site 585396011661 S8 interaction site; other site 585396011662 16S rRNA interaction site [nucleotide binding]; other site 585396011663 streptomycin interaction site [chemical binding]; other site 585396011664 23S rRNA interaction site [nucleotide binding]; other site 585396011665 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 585396011666 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 585396011667 sulfur relay protein TusC; Validated; Region: PRK00211 585396011668 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 585396011669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 585396011670 YheO-like PAS domain; Region: PAS_6; pfam08348 585396011671 HTH domain; Region: HTH_22; pfam13309 585396011672 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 585396011673 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 585396011674 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585396011675 phi X174 lysis protein; Provisional; Region: PRK02793 585396011676 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 585396011677 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585396011678 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 585396011679 potassium:proton antiporter KefB, C-terminal fragment 585396011680 potassium:proton antiporter KefB, N-terminal fragment 585396011681 component of potassium efflux complex with KefB, C-terminal fragment 585396011682 component of potassium efflux complex with KefB, N-terminal part 585396011683 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 585396011684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396011685 Walker A/P-loop; other site 585396011686 ATP binding site [chemical binding]; other site 585396011687 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585396011688 ABC transporter signature motif; other site 585396011689 Walker B; other site 585396011690 D-loop; other site 585396011691 ABC transporter; Region: ABC_tran_2; pfam12848 585396011692 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585396011693 putative hydrolase; Provisional; Region: PRK10985 585396011694 hypothetical protein; Provisional; Region: PRK04966 585396011695 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 585396011696 active site 585396011697 hypothetical protein; Provisional; Region: PRK10738 585396011698 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 585396011699 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585396011700 ligand binding site [chemical binding]; other site 585396011701 flexible hinge region; other site 585396011702 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 585396011703 putative switch regulator; other site 585396011704 non-specific DNA interactions [nucleotide binding]; other site 585396011705 DNA binding site [nucleotide binding] 585396011706 sequence specific DNA binding site [nucleotide binding]; other site 585396011707 putative cAMP binding site [chemical binding]; other site 585396011708 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 585396011709 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 585396011710 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585396011711 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 585396011712 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585396011713 inhibitor-cofactor binding pocket; inhibition site 585396011714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396011715 catalytic residue [active] 585396011716 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 585396011717 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 585396011718 glutamine binding [chemical binding]; other site 585396011719 catalytic triad [active] 585396011720 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 585396011721 cell filamentation protein Fic; Provisional; Region: PRK10347 585396011722 hypothetical protein; Provisional; Region: PRK10204 585396011723 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 585396011724 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 585396011725 substrate binding site [chemical binding]; other site 585396011726 putative transporter; Provisional; Region: PRK03699 585396011727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396011728 putative substrate translocation pore; other site 585396011729 nitrite reductase subunit NirD; Provisional; Region: PRK14989 585396011730 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396011731 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585396011732 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585396011733 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585396011734 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 585396011735 nitrite transporter NirC; Provisional; Region: PRK11562 585396011736 siroheme synthase; Provisional; Region: cysG; PRK10637 585396011737 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 585396011738 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 585396011739 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 585396011740 active site 585396011741 SAM binding site [chemical binding]; other site 585396011742 homodimer interface [polypeptide binding]; other site 585396011743 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 585396011744 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 585396011745 hypothetical protein; Provisional; Region: PHA02764 585396011746 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 585396011747 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 585396011748 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 585396011749 dimer interface [polypeptide binding]; other site 585396011750 active site 585396011751 fructoselysine 3-epimerase; Provisional; Region: PRK09856 585396011752 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 585396011753 AP (apurinic/apyrimidinic) site pocket; other site 585396011754 DNA interaction; other site 585396011755 Metal-binding active site; metal-binding site 585396011756 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 585396011757 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585396011758 substrate binding site [chemical binding]; other site 585396011759 ATP binding site [chemical binding]; other site 585396011760 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 585396011761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396011762 DNA-binding site [nucleotide binding]; DNA binding site 585396011763 UTRA domain; Region: UTRA; pfam07702 585396011764 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585396011765 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 585396011766 Protein of unknown function; Region: YhfT; pfam10797 585396011767 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 585396011768 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 585396011769 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 585396011770 active site 585396011771 substrate binding pocket [chemical binding]; other site 585396011772 homodimer interaction site [polypeptide binding]; other site 585396011773 putative mutase; Provisional; Region: PRK12383 585396011774 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 585396011775 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 585396011776 dimer interface [polypeptide binding]; other site 585396011777 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 585396011778 active site 585396011779 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585396011780 substrate binding site [chemical binding]; other site 585396011781 catalytic residue [active] 585396011782 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 585396011783 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 585396011784 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 585396011785 active site 585396011786 HIGH motif; other site 585396011787 dimer interface [polypeptide binding]; other site 585396011788 KMSKS motif; other site 585396011789 phosphoglycolate phosphatase; Provisional; Region: PRK13222 585396011790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396011791 motif II; other site 585396011792 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 585396011793 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 585396011794 substrate binding site [chemical binding]; other site 585396011795 hexamer interface [polypeptide binding]; other site 585396011796 metal binding site [ion binding]; metal-binding site 585396011797 DNA adenine methylase; Provisional; Region: PRK10904 585396011798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 585396011799 cell division protein DamX; Validated; Region: PRK10905 585396011800 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 585396011801 active site 585396011802 dimer interface [polypeptide binding]; other site 585396011803 metal binding site [ion binding]; metal-binding site 585396011804 shikimate kinase; Reviewed; Region: aroK; PRK00131 585396011805 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 585396011806 ADP binding site [chemical binding]; other site 585396011807 magnesium binding site [ion binding]; other site 585396011808 putative shikimate binding site; other site 585396011809 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 585396011810 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585396011811 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 585396011812 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 585396011813 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 585396011814 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 585396011815 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 585396011816 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 585396011817 Transglycosylase; Region: Transgly; pfam00912 585396011818 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585396011819 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 585396011820 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585396011821 ADP-ribose binding site [chemical binding]; other site 585396011822 dimer interface [polypeptide binding]; other site 585396011823 active site 585396011824 nudix motif; other site 585396011825 metal binding site [ion binding]; metal-binding site 585396011826 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 585396011827 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 585396011828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396011829 motif II; other site 585396011830 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585396011831 RNA binding surface [nucleotide binding]; other site 585396011832 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 585396011833 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 585396011834 dimerization interface [polypeptide binding]; other site 585396011835 domain crossover interface; other site 585396011836 redox-dependent activation switch; other site 585396011837 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 585396011838 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 585396011839 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 585396011840 active site 585396011841 substrate-binding site [chemical binding]; other site 585396011842 metal-binding site [ion binding] 585396011843 ATP binding site [chemical binding]; other site 585396011844 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 585396011845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585396011846 dimerization interface [polypeptide binding]; other site 585396011847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396011848 dimer interface [polypeptide binding]; other site 585396011849 phosphorylation site [posttranslational modification] 585396011850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396011851 ATP binding site [chemical binding]; other site 585396011852 G-X-G motif; other site 585396011853 osmolarity response regulator; Provisional; Region: ompR; PRK09468 585396011854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396011855 active site 585396011856 phosphorylation site [posttranslational modification] 585396011857 intermolecular recognition site; other site 585396011858 dimerization interface [polypeptide binding]; other site 585396011859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396011860 DNA binding site [nucleotide binding] 585396011861 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 585396011862 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 585396011863 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585396011864 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 585396011865 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 585396011866 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 585396011867 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 585396011868 RNA binding site [nucleotide binding]; other site 585396011869 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 585396011870 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 585396011871 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 585396011872 G1 box; other site 585396011873 GTP/Mg2+ binding site [chemical binding]; other site 585396011874 Switch I region; other site 585396011875 G2 box; other site 585396011876 G3 box; other site 585396011877 Switch II region; other site 585396011878 G4 box; other site 585396011879 G5 box; other site 585396011880 Nucleoside recognition; Region: Gate; pfam07670 585396011881 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 585396011882 Nucleoside recognition; Region: Gate; pfam07670 585396011883 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 585396011884 putative transposase; Provisional; Region: PRK09857 585396011885 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585396011886 carboxylesterase BioH; Provisional; Region: PRK10349 585396011887 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 585396011888 DNA utilization protein GntX; Provisional; Region: PRK11595 585396011889 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585396011890 active site 585396011891 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 585396011892 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 585396011893 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 585396011894 high-affinity gluconate transporter; Provisional; Region: PRK14984 585396011895 gluconate transporter; Region: gntP; TIGR00791 585396011896 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 585396011897 4-alpha-glucanotransferase; Region: malQ; TIGR00217 585396011898 maltodextrin phosphorylase; Provisional; Region: PRK14985 585396011899 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 585396011900 homodimer interface [polypeptide binding]; other site 585396011901 active site pocket [active] 585396011902 transcriptional regulator MalT; Provisional; Region: PRK04841 585396011903 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396011904 DNA binding residues [nucleotide binding] 585396011905 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 585396011906 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 585396011907 putative active site [active] 585396011908 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 585396011909 hypothetical protein; Reviewed; Region: PRK09588 585396011910 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 585396011911 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 585396011912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396011913 Walker A motif; other site 585396011914 ATP binding site [chemical binding]; other site 585396011915 Walker B motif; other site 585396011916 arginine finger; other site 585396011917 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 585396011918 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585396011919 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585396011920 intramembrane serine protease GlpG; Provisional; Region: PRK10907 585396011921 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 585396011922 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 585396011923 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 585396011924 active site residue [active] 585396011925 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 585396011926 hypothetical protein; Provisional; Region: PRK09781; cl08057 585396011927 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 585396011928 glycogen phosphorylase; Provisional; Region: PRK14986 585396011929 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 585396011930 homodimer interface [polypeptide binding]; other site 585396011931 active site pocket [active] 585396011932 glycogen synthase; Provisional; Region: glgA; PRK00654 585396011933 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 585396011934 ADP-binding pocket [chemical binding]; other site 585396011935 homodimer interface [polypeptide binding]; other site 585396011936 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 585396011937 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 585396011938 ligand binding site; other site 585396011939 oligomer interface; other site 585396011940 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 585396011941 sulfate 1 binding site; other site 585396011942 glycogen debranching enzyme; Provisional; Region: PRK03705 585396011943 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 585396011944 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 585396011945 active site 585396011946 catalytic site [active] 585396011947 glycogen branching enzyme; Provisional; Region: PRK05402 585396011948 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 585396011949 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 585396011950 active site 585396011951 catalytic site [active] 585396011952 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 585396011953 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 585396011954 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585396011955 putative antibiotic transporter; Provisional; Region: PRK10739 585396011956 low affinity gluconate transporter; Provisional; Region: PRK10472 585396011957 gluconate transporter; Region: gntP; TIGR00791 585396011958 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 585396011959 ATP-binding site [chemical binding]; other site 585396011960 Gluconate-6-phosphate binding site [chemical binding]; other site 585396011961 Shikimate kinase; Region: SKI; pfam01202 585396011962 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 585396011963 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396011964 DNA binding site [nucleotide binding] 585396011965 domain linker motif; other site 585396011966 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 585396011967 putative ligand binding site [chemical binding]; other site 585396011968 putative dimerization interface [polypeptide binding]; other site 585396011969 Pirin-related protein [General function prediction only]; Region: COG1741 585396011970 Pirin; Region: Pirin; pfam02678 585396011971 putative oxidoreductase; Provisional; Region: PRK10206 585396011972 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585396011973 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585396011974 putative acetyltransferase YhhY; Provisional; Region: PRK10140 585396011975 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396011976 Coenzyme A binding pocket [chemical binding]; other site 585396011977 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 585396011978 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 585396011979 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 585396011980 hypothetical protein; Provisional; Region: PRK10350 585396011981 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 585396011982 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 585396011983 putative active site [active] 585396011984 catalytic site [active] 585396011985 putative metal binding site [ion binding]; other site 585396011986 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 585396011987 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585396011988 Walker A/P-loop; other site 585396011989 ATP binding site [chemical binding]; other site 585396011990 Q-loop/lid; other site 585396011991 ABC transporter signature motif; other site 585396011992 Walker B; other site 585396011993 D-loop; other site 585396011994 H-loop/switch region; other site 585396011995 TOBE domain; Region: TOBE_2; pfam08402 585396011996 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 585396011997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396011998 dimer interface [polypeptide binding]; other site 585396011999 conserved gate region; other site 585396012000 putative PBP binding loops; other site 585396012001 ABC-ATPase subunit interface; other site 585396012002 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 585396012003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396012004 dimer interface [polypeptide binding]; other site 585396012005 conserved gate region; other site 585396012006 putative PBP binding loops; other site 585396012007 ABC-ATPase subunit interface; other site 585396012008 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 585396012009 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 585396012010 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 585396012011 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 585396012012 Walker A/P-loop; other site 585396012013 ATP binding site [chemical binding]; other site 585396012014 Q-loop/lid; other site 585396012015 ABC transporter signature motif; other site 585396012016 Walker B; other site 585396012017 D-loop; other site 585396012018 H-loop/switch region; other site 585396012019 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 585396012020 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 585396012021 Walker A/P-loop; other site 585396012022 ATP binding site [chemical binding]; other site 585396012023 Q-loop/lid; other site 585396012024 ABC transporter signature motif; other site 585396012025 Walker B; other site 585396012026 D-loop; other site 585396012027 H-loop/switch region; other site 585396012028 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 585396012029 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 585396012030 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 585396012031 TM-ABC transporter signature motif; other site 585396012032 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585396012033 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 585396012034 TM-ABC transporter signature motif; other site 585396012035 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 585396012036 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 585396012037 dimerization interface [polypeptide binding]; other site 585396012038 ligand binding site [chemical binding]; other site 585396012039 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 585396012040 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 585396012041 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 585396012042 dimerization interface [polypeptide binding]; other site 585396012043 ligand binding site [chemical binding]; other site 585396012044 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 585396012045 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585396012046 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585396012047 DNA binding residues [nucleotide binding] 585396012048 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 585396012049 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 585396012050 cell division protein FtsE; Provisional; Region: PRK10908 585396012051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396012052 Walker A/P-loop; other site 585396012053 ATP binding site [chemical binding]; other site 585396012054 Q-loop/lid; other site 585396012055 ABC transporter signature motif; other site 585396012056 Walker B; other site 585396012057 D-loop; other site 585396012058 H-loop/switch region; other site 585396012059 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 585396012060 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 585396012061 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 585396012062 P loop; other site 585396012063 GTP binding site [chemical binding]; other site 585396012064 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 585396012065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396012066 S-adenosylmethionine binding site [chemical binding]; other site 585396012067 hypothetical protein; Provisional; Region: PRK10910 585396012068 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 585396012069 Predicted membrane protein [Function unknown]; Region: COG3714 585396012070 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 585396012071 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585396012072 metal-binding site [ion binding] 585396012073 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585396012074 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 585396012075 CPxP motif; other site 585396012076 hypothetical protein; Provisional; Region: PRK11212 585396012077 hypothetical protein; Provisional; Region: PRK11615 585396012078 major facilitator superfamily transporter; Provisional; Region: PRK05122 585396012079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396012080 putative substrate translocation pore; other site 585396012081 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 585396012082 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585396012083 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 585396012084 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 585396012085 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 585396012086 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 585396012087 substrate binding site [chemical binding]; other site 585396012088 nickel transporter permease NikB; Provisional; Region: PRK10352 585396012089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396012090 dimer interface [polypeptide binding]; other site 585396012091 conserved gate region; other site 585396012092 putative PBP binding loops; other site 585396012093 ABC-ATPase subunit interface; other site 585396012094 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 585396012095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396012096 dimer interface [polypeptide binding]; other site 585396012097 conserved gate region; other site 585396012098 putative PBP binding loops; other site 585396012099 ABC-ATPase subunit interface; other site 585396012100 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 585396012101 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396012102 Walker A/P-loop; other site 585396012103 ATP binding site [chemical binding]; other site 585396012104 Q-loop/lid; other site 585396012105 ABC transporter signature motif; other site 585396012106 Walker B; other site 585396012107 D-loop; other site 585396012108 H-loop/switch region; other site 585396012109 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585396012110 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 585396012111 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396012112 Walker A/P-loop; other site 585396012113 ATP binding site [chemical binding]; other site 585396012114 Q-loop/lid; other site 585396012115 ABC transporter signature motif; other site 585396012116 Walker B; other site 585396012117 D-loop; other site 585396012118 H-loop/switch region; other site 585396012119 nickel responsive regulator; Provisional; Region: PRK02967 585396012120 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 585396012121 PAAR motif; Region: PAAR_motif; cl15808 585396012122 RHS Repeat; Region: RHS_repeat; pfam05593 585396012123 RHS Repeat; Region: RHS_repeat; pfam05593 585396012124 RHS Repeat; Region: RHS_repeat; cl11982 585396012125 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585396012126 RHS Repeat; Region: RHS_repeat; pfam05593 585396012127 RHS Repeat; Region: RHS_repeat; pfam05593 585396012128 RHS protein; Region: RHS; pfam03527 585396012129 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585396012130 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 585396012131 RhsB, IS677, putative H repeat-associated protein, N-terminal fragment 585396012132 RhsB, IS677, putative H repeat-associated protein, C-terminal fragment 585396012133 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585396012134 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 585396012135 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585396012136 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 585396012137 Walker A/P-loop; other site 585396012138 ATP binding site [chemical binding]; other site 585396012139 Q-loop/lid; other site 585396012140 ABC transporter signature motif; other site 585396012141 Walker B; other site 585396012142 D-loop; other site 585396012143 H-loop/switch region; other site 585396012144 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585396012145 Walker A/P-loop; other site 585396012146 ATP binding site [chemical binding]; other site 585396012147 Q-loop/lid; other site 585396012148 ABC transporter signature motif; other site 585396012149 Walker B; other site 585396012150 D-loop; other site 585396012151 H-loop/switch region; other site 585396012152 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585396012153 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 585396012154 HlyD family secretion protein; Region: HlyD; pfam00529 585396012155 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396012156 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396012157 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 585396012158 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 585396012159 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 585396012160 Predicted flavoproteins [General function prediction only]; Region: COG2081 585396012161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585396012162 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585396012163 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585396012164 universal stress protein UspB; Provisional; Region: PRK04960 585396012165 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585396012166 Ligand Binding Site [chemical binding]; other site 585396012167 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 585396012168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396012169 putative substrate translocation pore; other site 585396012170 POT family; Region: PTR2; pfam00854 585396012171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396012172 S-adenosylmethionine binding site [chemical binding]; other site 585396012173 oligopeptidase A; Provisional; Region: PRK10911 585396012174 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 585396012175 active site 585396012176 Zn binding site [ion binding]; other site 585396012177 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 585396012178 glutathione reductase; Validated; Region: PRK06116 585396012179 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585396012180 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396012181 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585396012182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585396012183 dimerization interface [polypeptide binding]; other site 585396012184 putative DNA binding site [nucleotide binding]; other site 585396012185 putative Zn2+ binding site [ion binding]; other site 585396012186 arsenical pump membrane protein; Provisional; Region: PRK15445 585396012187 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 585396012188 transmembrane helices; other site 585396012189 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 585396012190 ArsC family; Region: ArsC; pfam03960 585396012191 catalytic residues [active] 585396012192 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585396012193 dimerization interface [polypeptide binding]; other site 585396012194 putative DNA binding site [nucleotide binding]; other site 585396012195 putative Zn2+ binding site [ion binding]; other site 585396012196 Predicted permeases [General function prediction only]; Region: COG0701 585396012197 Transposase; Region: HTH_Tnp_1; cl17663 585396012198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396012199 putative transposase OrfB; Reviewed; Region: PHA02517 585396012200 HTH-like domain; Region: HTH_21; pfam13276 585396012201 Integrase core domain; Region: rve; pfam00665 585396012202 Integrase core domain; Region: rve_3; pfam13683 585396012203 conserved predicted protein, N-terminal fragment 585396012204 conserved predicted protein, partial 585396012205 conserved predicted protein, partial 585396012206 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 585396012207 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585396012208 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396012209 DNA binding residues [nucleotide binding] 585396012210 dimerization interface [polypeptide binding]; other site 585396012211 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 585396012212 MgtC family; Region: MgtC; pfam02308 585396012213 acid-resistance protein; Provisional; Region: hdeB; PRK11566 585396012214 acid-resistance protein; Provisional; Region: PRK10208 585396012215 acid-resistance membrane protein; Provisional; Region: PRK10209 585396012216 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 585396012217 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 585396012218 pyruvate kinase; Provisional; Region: PRK05826 585396012219 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 585396012220 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396012221 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396012222 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 585396012223 Protein export membrane protein; Region: SecD_SecF; cl14618 585396012224 transcriptional regulator YdeO; Provisional; Region: PRK09940 585396012225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396012226 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 585396012227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396012228 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 585396012229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396012230 catalytic residue [active] 585396012231 Haem-binding domain; Region: Haem_bd; pfam14376 585396012232 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 585396012233 trehalase; Provisional; Region: treF; PRK13270 585396012234 Trehalase; Region: Trehalase; pfam01204 585396012235 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585396012236 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396012237 DNA binding residues [nucleotide binding] 585396012238 dimerization interface [polypeptide binding]; other site 585396012239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585396012240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396012241 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 585396012242 putative effector binding pocket; other site 585396012243 putative dimerization interface [polypeptide binding]; other site 585396012244 inner membrane protein YhjD; Region: TIGR00766 585396012245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396012246 metabolite-proton symporter; Region: 2A0106; TIGR00883 585396012247 putative substrate translocation pore; other site 585396012248 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 585396012249 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585396012250 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396012251 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585396012252 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 585396012253 substrate binding site [chemical binding]; other site 585396012254 ATP binding site [chemical binding]; other site 585396012255 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585396012256 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585396012257 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 585396012258 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585396012259 putative diguanylate cyclase; Provisional; Region: PRK13561 585396012260 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585396012261 metal binding site [ion binding]; metal-binding site 585396012262 active site 585396012263 I-site; other site 585396012264 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396012265 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 585396012266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585396012267 binding surface 585396012268 TPR motif; other site 585396012269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585396012270 binding surface 585396012271 TPR motif; other site 585396012272 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 585396012273 endo-1,4-D-glucanase; Provisional; Region: PRK11097 585396012274 regulator of cellulose synthase BcsB, cyclic di-GMP binding, C-terminal fragment 585396012275 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 585396012276 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 585396012277 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 585396012278 DXD motif; other site 585396012279 PilZ domain; Region: PilZ; pfam07238 585396012280 cell division protein; Provisional; Region: PRK10037 585396012281 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 585396012282 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 585396012283 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 585396012284 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 585396012285 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 585396012286 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585396012287 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585396012288 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585396012289 serine transporter; Region: stp; TIGR00814 585396012290 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 585396012291 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396012292 Walker A/P-loop; other site 585396012293 ATP binding site [chemical binding]; other site 585396012294 Q-loop/lid; other site 585396012295 ABC transporter signature motif; other site 585396012296 Walker B; other site 585396012297 D-loop; other site 585396012298 H-loop/switch region; other site 585396012299 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585396012300 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 585396012301 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396012302 Walker A/P-loop; other site 585396012303 ATP binding site [chemical binding]; other site 585396012304 Q-loop/lid; other site 585396012305 ABC transporter signature motif; other site 585396012306 Walker B; other site 585396012307 D-loop; other site 585396012308 H-loop/switch region; other site 585396012309 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585396012310 dipeptide transporter; Provisional; Region: PRK10913 585396012311 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585396012312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396012313 dimer interface [polypeptide binding]; other site 585396012314 conserved gate region; other site 585396012315 putative PBP binding loops; other site 585396012316 ABC-ATPase subunit interface; other site 585396012317 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 585396012318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396012319 dimer interface [polypeptide binding]; other site 585396012320 conserved gate region; other site 585396012321 putative PBP binding loops; other site 585396012322 ABC-ATPase subunit interface; other site 585396012323 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 585396012324 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 585396012325 peptide binding site [polypeptide binding]; other site 585396012326 phosphoethanolamine transferase; Provisional; Region: PRK11560 585396012327 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585396012328 Sulfatase; Region: Sulfatase; pfam00884 585396012329 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 585396012330 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 585396012331 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 585396012332 PapC N-terminal domain; Region: PapC_N; pfam13954 585396012333 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585396012334 PapC C-terminal domain; Region: PapC_C; pfam13953 585396012335 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 585396012336 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585396012337 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585396012338 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 585396012339 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 585396012340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396012341 putative substrate translocation pore; other site 585396012342 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 585396012343 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 585396012344 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585396012345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396012346 Coenzyme A binding pocket [chemical binding]; other site 585396012347 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585396012348 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 585396012349 molybdopterin cofactor binding site [chemical binding]; other site 585396012350 substrate binding site [chemical binding]; other site 585396012351 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585396012352 molybdopterin cofactor binding site; other site 585396012353 putative outer membrane lipoprotein; Provisional; Region: PRK10510 585396012354 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585396012355 ligand binding site [chemical binding]; other site 585396012356 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 585396012357 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 585396012358 dimerization interface [polypeptide binding]; other site 585396012359 ligand binding site [chemical binding]; other site 585396012360 NADP binding site [chemical binding]; other site 585396012361 catalytic site [active] 585396012362 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 585396012363 Predicted transcriptional regulator [Transcription]; Region: COG2944 585396012364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396012365 non-specific DNA binding site [nucleotide binding]; other site 585396012366 salt bridge; other site 585396012367 sequence-specific DNA binding site [nucleotide binding]; other site 585396012368 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585396012369 DNA-binding site [nucleotide binding]; DNA binding site 585396012370 RNA-binding motif; other site 585396012371 small toxic polypeptide; Provisional; Region: PRK09759 585396012372 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 585396012373 DALR anticodon binding domain; Region: DALR_1; pfam05746 585396012374 anticodon binding site; other site 585396012375 tRNA binding surface [nucleotide binding]; other site 585396012376 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 585396012377 dimer interface [polypeptide binding]; other site 585396012378 motif 1; other site 585396012379 active site 585396012380 motif 2; other site 585396012381 motif 3; other site 585396012382 YsaB-like lipoprotein; Region: YsaB; pfam13983 585396012383 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 585396012384 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585396012385 hypothetical protein; Provisional; Region: PRK11383 585396012386 yiaA/B two helix domain; Region: YiaAB; pfam05360 585396012387 yiaA/B two helix domain; Region: YiaAB; pfam05360 585396012388 hypothetical protein; Provisional; Region: PRK11403 585396012389 yiaA/B two helix domain; Region: YiaAB; pfam05360 585396012390 xylulokinase; Provisional; Region: PRK15027 585396012391 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 585396012392 N- and C-terminal domain interface [polypeptide binding]; other site 585396012393 active site 585396012394 MgATP binding site [chemical binding]; other site 585396012395 catalytic site [active] 585396012396 metal binding site [ion binding]; metal-binding site 585396012397 xylulose binding site [chemical binding]; other site 585396012398 homodimer interface [polypeptide binding]; other site 585396012399 xylose isomerase; Provisional; Region: PRK05474 585396012400 xylose isomerase; Region: xylose_isom_A; TIGR02630 585396012401 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 585396012402 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 585396012403 putative ligand binding site [chemical binding]; other site 585396012404 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 585396012405 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585396012406 Walker A/P-loop; other site 585396012407 ATP binding site [chemical binding]; other site 585396012408 Q-loop/lid; other site 585396012409 ABC transporter signature motif; other site 585396012410 Walker B; other site 585396012411 D-loop; other site 585396012412 H-loop/switch region; other site 585396012413 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585396012414 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585396012415 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585396012416 TM-ABC transporter signature motif; other site 585396012417 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 585396012418 putative dimerization interface [polypeptide binding]; other site 585396012419 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585396012420 putative ligand binding site [chemical binding]; other site 585396012421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396012422 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585396012423 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396012424 hypothetical protein; Provisional; Region: PRK10356 585396012425 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 585396012426 alpha-amylase; Reviewed; Region: malS; PRK09505 585396012427 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 585396012428 active site 585396012429 catalytic site [active] 585396012430 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 585396012431 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585396012432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396012433 homodimer interface [polypeptide binding]; other site 585396012434 catalytic residue [active] 585396012435 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585396012436 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 585396012437 Transcriptional regulator [Transcription]; Region: IclR; COG1414 585396012438 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585396012439 Bacterial transcriptional regulator; Region: IclR; pfam01614 585396012440 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 585396012441 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 585396012442 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 585396012443 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 585396012444 DctM-like transporters; Region: DctM; pfam06808 585396012445 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585396012446 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 585396012447 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 585396012448 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 585396012449 putative N- and C-terminal domain interface [polypeptide binding]; other site 585396012450 putative active site [active] 585396012451 MgATP binding site [chemical binding]; other site 585396012452 catalytic site [active] 585396012453 metal binding site [ion binding]; metal-binding site 585396012454 putative xylulose binding site [chemical binding]; other site 585396012455 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 585396012456 active site 585396012457 dimer interface [polypeptide binding]; other site 585396012458 magnesium binding site [ion binding]; other site 585396012459 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 585396012460 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585396012461 AP (apurinic/apyrimidinic) site pocket; other site 585396012462 DNA interaction; other site 585396012463 Metal-binding active site; metal-binding site 585396012464 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585396012465 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585396012466 intersubunit interface [polypeptide binding]; other site 585396012467 active site 585396012468 Zn2+ binding site [ion binding]; other site 585396012469 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 585396012470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585396012471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396012472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585396012473 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585396012474 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396012475 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396012476 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 585396012477 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 585396012478 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 585396012479 NAD(P) binding site [chemical binding]; other site 585396012480 catalytic residues [active] 585396012481 putative alcohol dehydrogenase; Provisional; Region: PRK09860 585396012482 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 585396012483 dimer interface [polypeptide binding]; other site 585396012484 active site 585396012485 metal binding site [ion binding]; metal-binding site 585396012486 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 585396012487 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 585396012488 G1 box; other site 585396012489 putative GEF interaction site [polypeptide binding]; other site 585396012490 GTP/Mg2+ binding site [chemical binding]; other site 585396012491 Switch I region; other site 585396012492 G2 box; other site 585396012493 G3 box; other site 585396012494 Switch II region; other site 585396012495 G4 box; other site 585396012496 G5 box; other site 585396012497 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 585396012498 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 585396012499 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 585396012500 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 585396012501 selenocysteine synthase; Provisional; Region: PRK04311 585396012502 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 585396012503 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 585396012504 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585396012505 catalytic residue [active] 585396012506 putative glutathione S-transferase; Provisional; Region: PRK10357 585396012507 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 585396012508 putative C-terminal domain interface [polypeptide binding]; other site 585396012509 putative GSH binding site (G-site) [chemical binding]; other site 585396012510 putative dimer interface [polypeptide binding]; other site 585396012511 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 585396012512 dimer interface [polypeptide binding]; other site 585396012513 N-terminal domain interface [polypeptide binding]; other site 585396012514 putative substrate binding pocket (H-site) [chemical binding]; other site 585396012515 PAAR motif; Region: PAAR_motif; cl15808 585396012516 RHS Repeat; Region: RHS_repeat; pfam05593 585396012517 RHS Repeat; Region: RHS_repeat; pfam05593 585396012518 RHS Repeat; Region: RHS_repeat; cl11982 585396012519 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585396012520 RHS Repeat; Region: RHS_repeat; pfam05593 585396012521 RHS Repeat; Region: RHS_repeat; pfam05593 585396012522 RHS protein; Region: RHS; pfam03527 585396012523 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585396012524 putative lyase; Provisional; Region: PRK09687 585396012525 RhsA,RhsA core protein with extension, C-terminal fragment 585396012526 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585396012527 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585396012528 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396012529 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396012530 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 585396012531 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 585396012532 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 585396012533 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 585396012534 active site 585396012535 P-loop; other site 585396012536 phosphorylation site [posttranslational modification] 585396012537 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585396012538 active site 585396012539 phosphorylation site [posttranslational modification] 585396012540 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 585396012541 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585396012542 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585396012543 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 585396012544 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 585396012545 hypothetical protein; Provisional; Region: PRK11020 585396012546 conserved predicted protein, N-terminal part 585396012547 conserved predicted protein, C-terminal part 585396012548 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585396012549 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 585396012550 trimer interface [polypeptide binding]; other site 585396012551 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 585396012552 trimer interface [polypeptide binding]; other site 585396012553 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 585396012554 Haemagglutinin; Region: HIM; pfam05662 585396012555 Haemagglutinin; Region: HIM; pfam05662 585396012556 YadA-like C-terminal region; Region: YadA; pfam03895 585396012557 L-lactate permease; Provisional; Region: PRK10420 585396012558 glycolate transporter; Provisional; Region: PRK09695 585396012559 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 585396012560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396012561 DNA-binding site [nucleotide binding]; DNA binding site 585396012562 FCD domain; Region: FCD; pfam07729 585396012563 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 585396012564 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585396012565 phosphate binding site [ion binding]; other site 585396012566 putative rRNA methylase; Provisional; Region: PRK10358 585396012567 serine acetyltransferase; Provisional; Region: cysE; PRK11132 585396012568 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 585396012569 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585396012570 trimer interface [polypeptide binding]; other site 585396012571 active site 585396012572 substrate binding site [chemical binding]; other site 585396012573 CoA binding site [chemical binding]; other site 585396012574 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 585396012575 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 585396012576 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 585396012577 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 585396012578 SecA binding site; other site 585396012579 Preprotein binding site; other site 585396012580 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 585396012581 GSH binding site [chemical binding]; other site 585396012582 catalytic residues [active] 585396012583 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585396012584 active site residue [active] 585396012585 phosphoglyceromutase; Provisional; Region: PRK05434 585396012586 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 585396012587 AmiB activator; Provisional; Region: PRK11637 585396012588 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 585396012589 Peptidase family M23; Region: Peptidase_M23; pfam01551 585396012590 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 585396012591 NodB motif; other site 585396012592 putative active site [active] 585396012593 putative catalytic site [active] 585396012594 Zn binding site [ion binding]; other site 585396012595 putative glycosyl transferase; Provisional; Region: PRK10073 585396012596 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 585396012597 active site 585396012598 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 585396012599 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585396012600 NAD(P) binding site [chemical binding]; other site 585396012601 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585396012602 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 585396012603 substrate-cofactor binding pocket; other site 585396012604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396012605 catalytic residue [active] 585396012606 hypothetical protein; Provisional; Region: PRK11346 585396012607 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 585396012608 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 585396012609 NADP binding site [chemical binding]; other site 585396012610 homopentamer interface [polypeptide binding]; other site 585396012611 substrate binding site [chemical binding]; other site 585396012612 active site 585396012613 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585396012614 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585396012615 putative active site [active] 585396012616 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585396012617 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585396012618 putative active site [active] 585396012619 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 585396012620 O-antigen ligase RfaL; Provisional; Region: PRK15487 585396012621 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 585396012622 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585396012623 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 585396012624 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 585396012625 Ligand binding site; other site 585396012626 metal-binding site 585396012627 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 585396012628 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 585396012629 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 585396012630 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 585396012631 Ligand binding site; other site 585396012632 metal-binding site 585396012633 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 585396012634 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 585396012635 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585396012636 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585396012637 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 585396012638 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585396012639 putative active site [active] 585396012640 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 585396012641 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 585396012642 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585396012643 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 585396012644 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 585396012645 active site 585396012646 (T/H)XGH motif; other site 585396012647 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 585396012648 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 585396012649 DNA binding site [nucleotide binding] 585396012650 catalytic residue [active] 585396012651 H2TH interface [polypeptide binding]; other site 585396012652 putative catalytic residues [active] 585396012653 turnover-facilitating residue; other site 585396012654 intercalation triad [nucleotide binding]; other site 585396012655 8OG recognition residue [nucleotide binding]; other site 585396012656 putative reading head residues; other site 585396012657 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 585396012658 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585396012659 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 585396012660 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 585396012661 hypothetical protein; Reviewed; Region: PRK00024 585396012662 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585396012663 MPN+ (JAMM) motif; other site 585396012664 Zinc-binding site [ion binding]; other site 585396012665 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 585396012666 Flavoprotein; Region: Flavoprotein; pfam02441 585396012667 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 585396012668 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 585396012669 trimer interface [polypeptide binding]; other site 585396012670 active site 585396012671 division inhibitor protein; Provisional; Region: slmA; PRK09480 585396012672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585396012673 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585396012674 active site 585396012675 ribonuclease PH; Reviewed; Region: rph; PRK00173 585396012676 Ribonuclease PH; Region: RNase_PH_bact; cd11362 585396012677 hexamer interface [polypeptide binding]; other site 585396012678 active site 585396012679 hypothetical protein; Provisional; Region: PRK11820 585396012680 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 585396012681 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 585396012682 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 585396012683 BRO family, N-terminal domain; Region: Bro-N; pfam02498 585396012684 Predicted membrane protein [Function unknown]; Region: COG2860 585396012685 UPF0126 domain; Region: UPF0126; pfam03458 585396012686 UPF0126 domain; Region: UPF0126; pfam03458 585396012687 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 585396012688 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 585396012689 nucleotide binding pocket [chemical binding]; other site 585396012690 K-X-D-G motif; other site 585396012691 catalytic site [active] 585396012692 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 585396012693 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 585396012694 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 585396012695 catalytic site [active] 585396012696 G-X2-G-X-G-K; other site 585396012697 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 585396012698 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 585396012699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585396012700 Zn2+ binding site [ion binding]; other site 585396012701 Mg2+ binding site [ion binding]; other site 585396012702 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 585396012703 synthetase active site [active] 585396012704 NTP binding site [chemical binding]; other site 585396012705 metal binding site [ion binding]; metal-binding site 585396012706 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 585396012707 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 585396012708 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 585396012709 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585396012710 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 585396012711 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 585396012712 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 585396012713 generic binding surface II; other site 585396012714 ssDNA binding site; other site 585396012715 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585396012716 ATP binding site [chemical binding]; other site 585396012717 putative Mg++ binding site [ion binding]; other site 585396012718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396012719 nucleotide binding region [chemical binding]; other site 585396012720 ATP-binding site [chemical binding]; other site 585396012721 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 585396012722 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 585396012723 AsmA family; Region: AsmA; pfam05170 585396012724 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 585396012725 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585396012726 putative alpha-glucosidase; Provisional; Region: PRK10658 585396012727 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 585396012728 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 585396012729 active site 585396012730 homotrimer interface [polypeptide binding]; other site 585396012731 catalytic site [active] 585396012732 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 585396012733 putative transporter; Provisional; Region: PRK11462 585396012734 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 585396012735 sugar efflux transporter; Region: 2A0120; TIGR00899 585396012736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396012737 putative substrate translocation pore; other site 585396012738 EamA-like transporter family; Region: EamA; pfam00892 585396012739 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585396012740 EamA-like transporter family; Region: EamA; pfam00892 585396012741 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 585396012742 lipoprotein, YaeC family; Region: TIGR00363 585396012743 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 585396012744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396012745 putative substrate translocation pore; other site 585396012746 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 585396012747 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585396012748 cryptic adenine deaminase, N-terminal fragment 585396012749 cryptic adenine deaminase, C-terminal fragment 585396012750 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 585396012751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396012752 putative substrate translocation pore; other site 585396012753 regulatory protein UhpC; Provisional; Region: PRK11663 585396012754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396012755 putative substrate translocation pore; other site 585396012756 sensory histidine kinase UhpB; Provisional; Region: PRK11644 585396012757 MASE1; Region: MASE1; pfam05231 585396012758 Histidine kinase; Region: HisKA_3; pfam07730 585396012759 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 585396012760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396012761 active site 585396012762 phosphorylation site [posttranslational modification] 585396012763 intermolecular recognition site; other site 585396012764 dimerization interface [polypeptide binding]; other site 585396012765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396012766 DNA binding residues [nucleotide binding] 585396012767 dimerization interface [polypeptide binding]; other site 585396012768 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 585396012769 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 585396012770 putative valine binding site [chemical binding]; other site 585396012771 dimer interface [polypeptide binding]; other site 585396012772 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 585396012773 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585396012774 PYR/PP interface [polypeptide binding]; other site 585396012775 dimer interface [polypeptide binding]; other site 585396012776 TPP binding site [chemical binding]; other site 585396012777 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585396012778 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585396012779 TPP-binding site [chemical binding]; other site 585396012780 dimer interface [polypeptide binding]; other site 585396012781 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 585396012782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396012783 putative substrate translocation pore; other site 585396012784 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 585396012785 Domain of unknown function (DUF202); Region: DUF202; pfam02656 585396012786 Predicted membrane protein [Function unknown]; Region: COG2149 585396012787 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 585396012788 Sulfatase; Region: Sulfatase; pfam00884 585396012789 putative transporter; Provisional; Region: PRK10484 585396012790 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 585396012791 Na binding site [ion binding]; other site 585396012792 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585396012793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396012794 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585396012795 predicted 6-phospho-beta-glucosidase, C-terminal fragment 585396012796 Transposase; Region: HTH_Tnp_1; cl17663 585396012797 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396012798 putative transposase OrfB; Reviewed; Region: PHA02517 585396012799 HTH-like domain; Region: HTH_21; pfam13276 585396012800 Integrase core domain; Region: rve; pfam00665 585396012801 Integrase core domain; Region: rve_3; pfam13683 585396012802 predicted 6-phospho-beta-glucosidase, N-terminal fragment 585396012803 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 585396012804 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 585396012805 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585396012806 active site turn [active] 585396012807 phosphorylation site [posttranslational modification] 585396012808 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585396012809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396012810 DNA-binding site [nucleotide binding]; DNA binding site 585396012811 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 585396012812 putative transporter; Validated; Region: PRK03818 585396012813 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 585396012814 TrkA-C domain; Region: TrkA_C; pfam02080 585396012815 TrkA-C domain; Region: TrkA_C; pfam02080 585396012816 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 585396012817 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 585396012818 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 585396012819 putative dimer interface [polypeptide binding]; other site 585396012820 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 585396012821 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 585396012822 putative dimer interface [polypeptide binding]; other site 585396012823 hypothetical protein; Provisional; Region: PRK11616 585396012824 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 585396012825 putative oxidoreductase; Provisional; Region: PRK11445 585396012826 hypothetical protein; Provisional; Region: PRK07236 585396012827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396012828 D-galactonate transporter; Region: 2A0114; TIGR00893 585396012829 putative substrate translocation pore; other site 585396012830 galactonate dehydratase; Provisional; Region: PRK14017 585396012831 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 585396012832 putative active site pocket [active] 585396012833 putative metal binding site [ion binding]; other site 585396012834 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 585396012835 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 585396012836 active site 585396012837 intersubunit interface [polypeptide binding]; other site 585396012838 catalytic residue [active] 585396012839 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 585396012840 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 585396012841 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585396012842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396012843 DNA-binding site [nucleotide binding]; DNA binding site 585396012844 FCD domain; Region: FCD; pfam07729 585396012845 hypothetical protein; Provisional; Region: PRK10215 585396012846 sugar phosphate phosphatase; Provisional; Region: PRK10513 585396012847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396012848 active site 585396012849 motif I; other site 585396012850 motif II; other site 585396012851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396012852 hypothetical protein; Provisional; Region: PRK11426 585396012853 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 585396012854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396012855 Mg2+ binding site [ion binding]; other site 585396012856 G-X-G motif; other site 585396012857 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 585396012858 anchoring element; other site 585396012859 dimer interface [polypeptide binding]; other site 585396012860 ATP binding site [chemical binding]; other site 585396012861 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 585396012862 active site 585396012863 putative metal-binding site [ion binding]; other site 585396012864 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 585396012865 recF protein; Region: recf; TIGR00611 585396012866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396012867 Walker A/P-loop; other site 585396012868 ATP binding site [chemical binding]; other site 585396012869 Q-loop/lid; other site 585396012870 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396012871 ABC transporter signature motif; other site 585396012872 Walker B; other site 585396012873 D-loop; other site 585396012874 H-loop/switch region; other site 585396012875 DNA polymerase III subunit beta; Validated; Region: PRK05643 585396012876 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 585396012877 putative DNA binding surface [nucleotide binding]; other site 585396012878 dimer interface [polypeptide binding]; other site 585396012879 beta-clamp/clamp loader binding surface; other site 585396012880 beta-clamp/translesion DNA polymerase binding surface; other site 585396012881 DnaA N-terminal domain; Region: DnaA_N; pfam11638 585396012882 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 585396012883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396012884 Walker A motif; other site 585396012885 ATP binding site [chemical binding]; other site 585396012886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 585396012887 Walker B motif; other site 585396012888 arginine finger; other site 585396012889 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 585396012890 DnaA box-binding interface [nucleotide binding]; other site 585396012891 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 585396012892 ribonuclease P; Reviewed; Region: rnpA; PRK01732 585396012893 membrane protein insertase; Provisional; Region: PRK01318 585396012894 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 585396012895 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 585396012896 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 585396012897 trmE is a tRNA modification GTPase; Region: trmE; cd04164 585396012898 G1 box; other site 585396012899 GTP/Mg2+ binding site [chemical binding]; other site 585396012900 Switch I region; other site 585396012901 G2 box; other site 585396012902 Switch II region; other site 585396012903 G3 box; other site 585396012904 G4 box; other site 585396012905 G5 box; other site 585396012906 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 585396012907 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 585396012908 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 585396012909 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 585396012910 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585396012911 catalytic residue [active] 585396012912 tryptophan permease TnaB; Provisional; Region: PRK09664 585396012913 aromatic amino acid transport protein; Region: araaP; TIGR00837 585396012914 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 585396012915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396012916 putative substrate translocation pore; other site 585396012917 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 585396012918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396012919 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 585396012920 substrate binding pocket [chemical binding]; other site 585396012921 dimerization interface [polypeptide binding]; other site 585396012922 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 585396012923 Predicted flavoprotein [General function prediction only]; Region: COG0431 585396012924 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585396012925 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585396012926 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 585396012927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396012928 active site 585396012929 motif I; other site 585396012930 motif II; other site 585396012931 putative inner membrane protein; Provisional; Region: PRK09823 585396012932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 585396012933 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585396012934 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585396012935 active site 585396012936 trimer interface [polypeptide binding]; other site 585396012937 allosteric site; other site 585396012938 active site lid [active] 585396012939 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 585396012940 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 585396012941 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585396012942 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 585396012943 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585396012944 trimer interface; other site 585396012945 sugar binding site [chemical binding]; other site 585396012946 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 585396012947 beta-galactosidase; Region: BGL; TIGR03356 585396012948 fused beta-glucoside-specific PTS enzymes: IIA component/IIB component/IIC component, C-terminal fragment 585396012949 fused beta-glucoside-specific PTS enzymes: IIA component/IIB component/IIC component, N-terminal fragment 585396012950 transcriptional antiterminator BglG; Provisional; Region: PRK09772 585396012951 CAT RNA binding domain; Region: CAT_RBD; pfam03123 585396012952 PRD domain; Region: PRD; pfam00874 585396012953 PRD domain; Region: PRD; pfam00874 585396012954 transcriptional regulator PhoU; Provisional; Region: PRK11115 585396012955 PhoU domain; Region: PhoU; pfam01895 585396012956 PhoU domain; Region: PhoU; pfam01895 585396012957 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 585396012958 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 585396012959 Walker A/P-loop; other site 585396012960 ATP binding site [chemical binding]; other site 585396012961 Q-loop/lid; other site 585396012962 ABC transporter signature motif; other site 585396012963 Walker B; other site 585396012964 D-loop; other site 585396012965 H-loop/switch region; other site 585396012966 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 585396012967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396012968 dimer interface [polypeptide binding]; other site 585396012969 conserved gate region; other site 585396012970 putative PBP binding loops; other site 585396012971 ABC-ATPase subunit interface; other site 585396012972 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 585396012973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396012974 dimer interface [polypeptide binding]; other site 585396012975 conserved gate region; other site 585396012976 putative PBP binding loops; other site 585396012977 ABC-ATPase subunit interface; other site 585396012978 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396012979 putative fimbrial subunit protein, C-terminal fragment 585396012980 putative fimbrial subunit protein, N-terminal fragment 585396012981 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585396012982 PapC N-terminal domain; Region: PapC_N; pfam13954 585396012983 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585396012984 PapC C-terminal domain; Region: PapC_C; pfam13953 585396012985 fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290 585396012986 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585396012987 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585396012988 fimbrial protein; Provisional; Region: lpfA; PRK15289 585396012989 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 585396012990 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 585396012991 glutaminase active site [active] 585396012992 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 585396012993 dimer interface [polypeptide binding]; other site 585396012994 active site 585396012995 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 585396012996 dimer interface [polypeptide binding]; other site 585396012997 active site 585396012998 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 585396012999 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 585396013000 Substrate binding site; other site 585396013001 Mg++ binding site; other site 585396013002 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 585396013003 active site 585396013004 substrate binding site [chemical binding]; other site 585396013005 CoA binding site [chemical binding]; other site 585396013006 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 585396013007 Putative transposase; Region: Y2_Tnp; pfam04986 585396013008 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 585396013009 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 585396013010 gamma subunit interface [polypeptide binding]; other site 585396013011 epsilon subunit interface [polypeptide binding]; other site 585396013012 LBP interface [polypeptide binding]; other site 585396013013 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 585396013014 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 585396013015 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 585396013016 alpha subunit interaction interface [polypeptide binding]; other site 585396013017 Walker A motif; other site 585396013018 ATP binding site [chemical binding]; other site 585396013019 Walker B motif; other site 585396013020 inhibitor binding site; inhibition site 585396013021 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 585396013022 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 585396013023 core domain interface [polypeptide binding]; other site 585396013024 delta subunit interface [polypeptide binding]; other site 585396013025 epsilon subunit interface [polypeptide binding]; other site 585396013026 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 585396013027 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 585396013028 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 585396013029 beta subunit interaction interface [polypeptide binding]; other site 585396013030 Walker A motif; other site 585396013031 ATP binding site [chemical binding]; other site 585396013032 Walker B motif; other site 585396013033 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 585396013034 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 585396013035 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 585396013036 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 585396013037 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 585396013038 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 585396013039 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 585396013040 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 585396013041 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 585396013042 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 585396013043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396013044 S-adenosylmethionine binding site [chemical binding]; other site 585396013045 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 585396013046 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 585396013047 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 585396013048 FMN-binding protein MioC; Provisional; Region: PRK09004 585396013049 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 585396013050 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585396013051 putative DNA binding site [nucleotide binding]; other site 585396013052 putative Zn2+ binding site [ion binding]; other site 585396013053 AsnC family; Region: AsnC_trans_reg; pfam01037 585396013054 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 585396013055 dimer interface [polypeptide binding]; other site 585396013056 active site 585396013057 hypothetical protein; Provisional; Region: yieM; PRK10997 585396013058 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 585396013059 metal ion-dependent adhesion site (MIDAS); other site 585396013060 regulatory ATPase RavA; Provisional; Region: PRK13531 585396013061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396013062 Walker A motif; other site 585396013063 ATP binding site [chemical binding]; other site 585396013064 Walker B motif; other site 585396013065 arginine finger; other site 585396013066 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 585396013067 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 585396013068 potassium uptake protein; Region: kup; TIGR00794 585396013069 D-ribose pyranase; Provisional; Region: PRK11797 585396013070 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 585396013071 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585396013072 Walker A/P-loop; other site 585396013073 ATP binding site [chemical binding]; other site 585396013074 Q-loop/lid; other site 585396013075 ABC transporter signature motif; other site 585396013076 Walker B; other site 585396013077 D-loop; other site 585396013078 H-loop/switch region; other site 585396013079 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585396013080 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585396013081 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585396013082 TM-ABC transporter signature motif; other site 585396013083 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 585396013084 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 585396013085 ligand binding site [chemical binding]; other site 585396013086 dimerization interface [polypeptide binding]; other site 585396013087 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 585396013088 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585396013089 substrate binding site [chemical binding]; other site 585396013090 dimer interface [polypeptide binding]; other site 585396013091 ATP binding site [chemical binding]; other site 585396013092 transcriptional repressor RbsR; Provisional; Region: PRK10423 585396013093 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396013094 DNA binding site [nucleotide binding] 585396013095 domain linker motif; other site 585396013096 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 585396013097 dimerization interface [polypeptide binding]; other site 585396013098 ligand binding site [chemical binding]; other site 585396013099 putative transporter; Provisional; Region: PRK10504 585396013100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396013101 putative substrate translocation pore; other site 585396013102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396013103 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585396013104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396013105 DNA-binding site [nucleotide binding]; DNA binding site 585396013106 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585396013107 transcriptional regulator HdfR; Provisional; Region: PRK03601 585396013108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396013109 LysR substrate binding domain; Region: LysR_substrate; pfam03466 585396013110 dimerization interface [polypeptide binding]; other site 585396013111 hypothetical protein; Provisional; Region: PRK11027 585396013112 putative ATP-dependent protease; Provisional; Region: PRK09862 585396013113 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 585396013114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396013115 Walker A motif; other site 585396013116 ATP binding site [chemical binding]; other site 585396013117 Walker B motif; other site 585396013118 arginine finger; other site 585396013119 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 585396013120 ilvG operon leader peptide; Provisional; Region: PRK10424 585396013121 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 585396013122 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585396013123 PYR/PP interface [polypeptide binding]; other site 585396013124 dimer interface [polypeptide binding]; other site 585396013125 TPP binding site [chemical binding]; other site 585396013126 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585396013127 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585396013128 TPP-binding site [chemical binding]; other site 585396013129 dimer interface [polypeptide binding]; other site 585396013130 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 585396013131 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 585396013132 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 585396013133 homodimer interface [polypeptide binding]; other site 585396013134 substrate-cofactor binding pocket; other site 585396013135 catalytic residue [active] 585396013136 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 585396013137 threonine dehydratase; Reviewed; Region: PRK09224 585396013138 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 585396013139 tetramer interface [polypeptide binding]; other site 585396013140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396013141 catalytic residue [active] 585396013142 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 585396013143 putative Ile/Val binding site [chemical binding]; other site 585396013144 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 585396013145 putative Ile/Val binding site [chemical binding]; other site 585396013146 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396013147 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 585396013148 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 585396013149 putative dimerization interface [polypeptide binding]; other site 585396013150 ketol-acid reductoisomerase; Validated; Region: PRK05225 585396013151 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 585396013152 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 585396013153 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 585396013154 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 585396013155 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 585396013156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 585396013157 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 585396013158 Part of AAA domain; Region: AAA_19; pfam13245 585396013159 Family description; Region: UvrD_C_2; pfam13538 585396013160 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 585396013161 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 585396013162 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 585396013163 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585396013164 ATP binding site [chemical binding]; other site 585396013165 Mg++ binding site [ion binding]; other site 585396013166 motif III; other site 585396013167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396013168 nucleotide binding region [chemical binding]; other site 585396013169 ATP-binding site [chemical binding]; other site 585396013170 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 585396013171 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 585396013172 catalytic residues [active] 585396013173 putative rho operon leader peptide; Provisional; Region: PRK09979 585396013174 transcription termination factor Rho; Provisional; Region: rho; PRK09376 585396013175 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 585396013176 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 585396013177 RNA binding site [nucleotide binding]; other site 585396013178 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 585396013179 multimer interface [polypeptide binding]; other site 585396013180 Walker A motif; other site 585396013181 ATP binding site [chemical binding]; other site 585396013182 Walker B motif; other site 585396013183 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 585396013184 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 585396013185 Mg++ binding site [ion binding]; other site 585396013186 putative catalytic motif [active] 585396013187 substrate binding site [chemical binding]; other site 585396013188 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 585396013189 Chain length determinant protein; Region: Wzz; pfam02706 585396013190 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 585396013191 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 585396013192 active site 585396013193 homodimer interface [polypeptide binding]; other site 585396013194 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 585396013195 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 585396013196 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 585396013197 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 585396013198 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 585396013199 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 585396013200 NAD binding site [chemical binding]; other site 585396013201 substrate binding site [chemical binding]; other site 585396013202 homodimer interface [polypeptide binding]; other site 585396013203 active site 585396013204 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 585396013205 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 585396013206 substrate binding site; other site 585396013207 tetramer interface; other site 585396013208 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 585396013209 Coenzyme A binding pocket [chemical binding]; other site 585396013210 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 585396013211 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 585396013212 inhibitor-cofactor binding pocket; inhibition site 585396013213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396013214 catalytic residue [active] 585396013215 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 585396013216 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 585396013217 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 585396013218 putative common antigen polymerase; Provisional; Region: PRK02975 585396013219 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 585396013220 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 585396013221 putative transport protein YifK; Provisional; Region: PRK10746 585396013222 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 585396013223 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396013224 FeS/SAM binding site; other site 585396013225 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 585396013226 acrylsulfatase-like enzyme AslA, N-terminal fragment 585396013227 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 585396013228 HemY protein N-terminus; Region: HemY_N; pfam07219 585396013229 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 585396013230 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 585396013231 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 585396013232 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 585396013233 active site 585396013234 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 585396013235 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 585396013236 domain interfaces; other site 585396013237 active site 585396013238 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 585396013239 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 585396013240 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 585396013241 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 585396013242 putative iron binding site [ion binding]; other site 585396013243 DKNYY family; Region: DKNYY; pfam13644 585396013244 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 585396013245 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 585396013246 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 585396013247 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 585396013248 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 585396013249 hypothetical protein; Provisional; Region: PRK10963 585396013250 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 585396013251 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585396013252 active site 585396013253 DNA binding site [nucleotide binding] 585396013254 Int/Topo IB signature motif; other site 585396013255 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 585396013256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396013257 motif II; other site 585396013258 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 585396013259 Part of AAA domain; Region: AAA_19; pfam13245 585396013260 Family description; Region: UvrD_C_2; pfam13538 585396013261 Predicted periplasmic protein [Function unknown]; Region: COG3698 585396013262 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 585396013263 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 585396013264 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 585396013265 Cl binding site [ion binding]; other site 585396013266 oligomer interface [polypeptide binding]; other site 585396013267 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 585396013268 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 585396013269 magnesium and cobalt transport protein CorA, C-terminal fragment 585396013270 predicted chloramphenicol resistance permease RadD, C-terminal fragment 585396013271 predicted chloramphenicol resistance permease RadD, N-terminal fragment 585396013272 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585396013273 CoenzymeA binding site [chemical binding]; other site 585396013274 subunit interaction site [polypeptide binding]; other site 585396013275 PHB binding site; other site 585396013276 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 585396013277 dimerization interface [polypeptide binding]; other site 585396013278 substrate binding site [chemical binding]; other site 585396013279 active site 585396013280 calcium binding site [ion binding]; other site 585396013281 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 585396013282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585396013283 ATP binding site [chemical binding]; other site 585396013284 putative Mg++ binding site [ion binding]; other site 585396013285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396013286 nucleotide binding region [chemical binding]; other site 585396013287 ATP-binding site [chemical binding]; other site 585396013288 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 585396013289 Helicase and RNase D C-terminal; Region: HRDC; smart00341 585396013290 threonine efflux system; Provisional; Region: PRK10229 585396013291 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 585396013292 lysophospholipase L2; Provisional; Region: PRK10749 585396013293 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585396013294 putative hydrolase; Provisional; Region: PRK10976 585396013295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396013296 active site 585396013297 motif I; other site 585396013298 motif II; other site 585396013299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396013300 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585396013301 EamA-like transporter family; Region: EamA; pfam00892 585396013302 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 585396013303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396013304 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 585396013305 putative dimerization interface [polypeptide binding]; other site 585396013306 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 585396013307 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 585396013308 THF binding site; other site 585396013309 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 585396013310 substrate binding site [chemical binding]; other site 585396013311 THF binding site; other site 585396013312 zinc-binding site [ion binding]; other site 585396013313 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 585396013314 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 585396013315 uridine phosphorylase; Provisional; Region: PRK11178 585396013316 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 585396013317 DNA recombination protein RmuC; Provisional; Region: PRK10361 585396013318 RmuC family; Region: RmuC; pfam02646 585396013319 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 585396013320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396013321 S-adenosylmethionine binding site [chemical binding]; other site 585396013322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 585396013323 SCP-2 sterol transfer family; Region: SCP2; pfam02036 585396013324 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 585396013325 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 585396013326 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 585396013327 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 585396013328 sec-independent translocase; Provisional; Region: PRK01770 585396013329 sec-independent translocase; Provisional; Region: tatB; PRK00404 585396013330 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 585396013331 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585396013332 active site 585396013333 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 585396013334 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 585396013335 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 585396013336 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 585396013337 FMN reductase; Validated; Region: fre; PRK08051 585396013338 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 585396013339 FAD binding pocket [chemical binding]; other site 585396013340 FAD binding motif [chemical binding]; other site 585396013341 phosphate binding motif [ion binding]; other site 585396013342 beta-alpha-beta structure motif; other site 585396013343 NAD binding pocket [chemical binding]; other site 585396013344 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 585396013345 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585396013346 dimer interface [polypeptide binding]; other site 585396013347 active site 585396013348 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 585396013349 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585396013350 substrate binding site [chemical binding]; other site 585396013351 oxyanion hole (OAH) forming residues; other site 585396013352 trimer interface [polypeptide binding]; other site 585396013353 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585396013354 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585396013355 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585396013356 proline dipeptidase; Provisional; Region: PRK13607 585396013357 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 585396013358 active site 585396013359 hypothetical protein; Provisional; Region: PRK11568 585396013360 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 585396013361 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 585396013362 potassium transporter; Provisional; Region: PRK10750 585396013363 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 585396013364 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 585396013365 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 585396013366 Walker A motif; other site 585396013367 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 585396013368 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 585396013369 GTP binding site; other site 585396013370 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 585396013371 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 585396013372 serine/threonine protein kinase; Provisional; Region: PRK11768 585396013373 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 585396013374 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 585396013375 catalytic residues [active] 585396013376 hinge region; other site 585396013377 alpha helical domain; other site 585396013378 hypothetical protein; Provisional; Region: PRK11367 585396013379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 585396013380 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 585396013381 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 585396013382 putative acyl-acceptor binding pocket; other site 585396013383 DNA polymerase I; Provisional; Region: PRK05755 585396013384 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 585396013385 active site 585396013386 metal binding site 1 [ion binding]; metal-binding site 585396013387 putative 5' ssDNA interaction site; other site 585396013388 metal binding site 3; metal-binding site 585396013389 metal binding site 2 [ion binding]; metal-binding site 585396013390 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 585396013391 putative DNA binding site [nucleotide binding]; other site 585396013392 putative metal binding site [ion binding]; other site 585396013393 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 585396013394 active site 585396013395 catalytic site [active] 585396013396 substrate binding site [chemical binding]; other site 585396013397 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 585396013398 active site 585396013399 DNA binding site [nucleotide binding] 585396013400 catalytic site [active] 585396013401 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 585396013402 G1 box; other site 585396013403 GTP/Mg2+ binding site [chemical binding]; other site 585396013404 Switch I region; other site 585396013405 G2 box; other site 585396013406 G3 box; other site 585396013407 Switch II region; other site 585396013408 G4 box; other site 585396013409 G5 box; other site 585396013410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 585396013411 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 585396013412 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396013413 FeS/SAM binding site; other site 585396013414 HemN C-terminal domain; Region: HemN_C; pfam06969 585396013415 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 585396013416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396013417 active site 585396013418 phosphorylation site [posttranslational modification] 585396013419 intermolecular recognition site; other site 585396013420 dimerization interface [polypeptide binding]; other site 585396013421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396013422 Walker A motif; other site 585396013423 ATP binding site [chemical binding]; other site 585396013424 Walker B motif; other site 585396013425 arginine finger; other site 585396013426 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585396013427 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 585396013428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585396013429 putative active site [active] 585396013430 heme pocket [chemical binding]; other site 585396013431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396013432 dimer interface [polypeptide binding]; other site 585396013433 phosphorylation site [posttranslational modification] 585396013434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396013435 ATP binding site [chemical binding]; other site 585396013436 Mg2+ binding site [ion binding]; other site 585396013437 G-X-G motif; other site 585396013438 glutamine synthetase; Provisional; Region: glnA; PRK09469 585396013439 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 585396013440 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 585396013441 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 585396013442 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 585396013443 G1 box; other site 585396013444 putative GEF interaction site [polypeptide binding]; other site 585396013445 GTP/Mg2+ binding site [chemical binding]; other site 585396013446 Switch I region; other site 585396013447 G2 box; other site 585396013448 G3 box; other site 585396013449 Switch II region; other site 585396013450 G4 box; other site 585396013451 G5 box; other site 585396013452 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 585396013453 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 585396013454 transcriptional regulator protein; Region: phnR; TIGR03337 585396013455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396013456 DNA-binding site [nucleotide binding]; DNA binding site 585396013457 UTRA domain; Region: UTRA; pfam07702 585396013458 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 585396013459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396013460 putative substrate translocation pore; other site 585396013461 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 585396013462 outer membrane porin L; Provisional; Region: ompL; PRK09980 585396013463 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 585396013464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396013465 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 585396013466 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 585396013467 alpha-glucosidase; Provisional; Region: PRK10426 585396013468 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 585396013469 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 585396013470 putative active site [active] 585396013471 putative catalytic site [active] 585396013472 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 585396013473 active site 585396013474 catalytic residues [active] 585396013475 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 585396013476 dimerization interface [polypeptide binding]; other site 585396013477 putative active cleft [active] 585396013478 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 585396013479 catalytic residue [active] 585396013480 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 585396013481 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585396013482 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585396013483 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 585396013484 substrate binding site [chemical binding]; other site 585396013485 ATP binding site [chemical binding]; other site 585396013486 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585396013487 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585396013488 putative DNA binding site [nucleotide binding]; other site 585396013489 putative Zn2+ binding site [ion binding]; other site 585396013490 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585396013491 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 585396013492 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396013493 motif II; other site 585396013494 hypothetical protein; Reviewed; Region: PRK01637 585396013495 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 585396013496 putative active site [active] 585396013497 dimerization interface [polypeptide binding]; other site 585396013498 putative tRNAtyr binding site [nucleotide binding]; other site 585396013499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396013500 Coenzyme A binding pocket [chemical binding]; other site 585396013501 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 585396013502 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 585396013503 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 585396013504 substrate binding pocket [chemical binding]; other site 585396013505 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396013506 non-specific DNA binding site [nucleotide binding]; other site 585396013507 salt bridge; other site 585396013508 sequence-specific DNA binding site [nucleotide binding]; other site 585396013509 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 585396013510 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 585396013511 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 585396013512 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 585396013513 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 585396013514 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 585396013515 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 585396013516 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 585396013517 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585396013518 [4Fe-4S] binding site [ion binding]; other site 585396013519 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585396013520 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585396013521 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 585396013522 molybdopterin cofactor binding site; other site 585396013523 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 585396013524 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 585396013525 putative frv operon regulatory protein; Provisional; Region: PRK09863 585396013526 HTH domain; Region: HTH_11; pfam08279 585396013527 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585396013528 active site 585396013529 phosphorylation site [posttranslational modification] 585396013530 putative peptidase; Provisional; Region: PRK09864 585396013531 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 585396013532 oligomer interface [polypeptide binding]; other site 585396013533 active site 585396013534 metal binding site [ion binding]; metal-binding site 585396013535 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 585396013536 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585396013537 active site 585396013538 P-loop; other site 585396013539 phosphorylation site [posttranslational modification] 585396013540 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 585396013541 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585396013542 active site 585396013543 phosphorylation site [posttranslational modification] 585396013544 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 585396013545 lactaldehyde reductase; Region: lactal_redase; TIGR02638 585396013546 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 585396013547 dimer interface [polypeptide binding]; other site 585396013548 active site 585396013549 metal binding site [ion binding]; metal-binding site 585396013550 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585396013551 intersubunit interface [polypeptide binding]; other site 585396013552 active site 585396013553 Zn2+ binding site [ion binding]; other site 585396013554 L-rhamnose isomerase; Provisional; Region: PRK01076 585396013555 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 585396013556 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 585396013557 N- and C-terminal domain interface [polypeptide binding]; other site 585396013558 active site 585396013559 putative catalytic site [active] 585396013560 metal binding site [ion binding]; metal-binding site 585396013561 ATP binding site [chemical binding]; other site 585396013562 rhamnulokinase; Provisional; Region: rhaB; PRK10640 585396013563 carbohydrate binding site [chemical binding]; other site 585396013564 transcriptional activator RhaS; Provisional; Region: PRK13503 585396013565 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585396013566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396013567 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396013568 transcriptional activator RhaR; Provisional; Region: PRK13500 585396013569 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585396013570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396013571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396013572 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 585396013573 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 585396013574 superoxide dismutase; Provisional; Region: PRK10925 585396013575 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 585396013576 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 585396013577 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 585396013578 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 585396013579 MOSC domain; Region: MOSC; pfam03473 585396013580 3-alpha domain; Region: 3-alpha; pfam03475 585396013581 two-component sensor protein; Provisional; Region: cpxA; PRK09470 585396013582 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585396013583 dimerization interface [polypeptide binding]; other site 585396013584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396013585 dimer interface [polypeptide binding]; other site 585396013586 phosphorylation site [posttranslational modification] 585396013587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396013588 ATP binding site [chemical binding]; other site 585396013589 Mg2+ binding site [ion binding]; other site 585396013590 G-X-G motif; other site 585396013591 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 585396013592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396013593 active site 585396013594 intermolecular recognition site; other site 585396013595 dimerization interface [polypeptide binding]; other site 585396013596 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396013597 DNA binding site [nucleotide binding] 585396013598 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 585396013599 dimer interface [polypeptide binding]; other site 585396013600 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 585396013601 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 585396013602 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 585396013603 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 585396013604 active site 585396013605 ADP/pyrophosphate binding site [chemical binding]; other site 585396013606 dimerization interface [polypeptide binding]; other site 585396013607 allosteric effector site; other site 585396013608 fructose-1,6-bisphosphate binding site; other site 585396013609 sulfate transporter subunit; Provisional; Region: PRK10752 585396013610 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 585396013611 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 585396013612 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 585396013613 triosephosphate isomerase; Provisional; Region: PRK14567 585396013614 substrate binding site [chemical binding]; other site 585396013615 dimer interface [polypeptide binding]; other site 585396013616 catalytic triad [active] 585396013617 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 585396013618 Predicted membrane protein [Function unknown]; Region: COG3152 585396013619 hypothetical protein; Provisional; Region: PRK09981 585396013620 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585396013621 Ligand Binding Site [chemical binding]; other site 585396013622 ferredoxin-NADP reductase; Provisional; Region: PRK10926 585396013623 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 585396013624 FAD binding pocket [chemical binding]; other site 585396013625 FAD binding motif [chemical binding]; other site 585396013626 phosphate binding motif [ion binding]; other site 585396013627 beta-alpha-beta structure motif; other site 585396013628 NAD binding pocket [chemical binding]; other site 585396013629 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 585396013630 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 585396013631 putative active site [active] 585396013632 glycerol kinase; Provisional; Region: glpK; PRK00047 585396013633 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 585396013634 N- and C-terminal domain interface [polypeptide binding]; other site 585396013635 active site 585396013636 MgATP binding site [chemical binding]; other site 585396013637 catalytic site [active] 585396013638 metal binding site [ion binding]; metal-binding site 585396013639 glycerol binding site [chemical binding]; other site 585396013640 homotetramer interface [polypeptide binding]; other site 585396013641 homodimer interface [polypeptide binding]; other site 585396013642 FBP binding site [chemical binding]; other site 585396013643 protein IIAGlc interface [polypeptide binding]; other site 585396013644 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 585396013645 amphipathic channel; other site 585396013646 Asn-Pro-Ala signature motifs; other site 585396013647 septal ring assembly protein ZapB; Provisional; Region: PRK15422 585396013648 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 585396013649 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 585396013650 UbiA prenyltransferase family; Region: UbiA; pfam01040 585396013651 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 585396013652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396013653 Walker A motif; other site 585396013654 ATP binding site [chemical binding]; other site 585396013655 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 585396013656 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585396013657 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 585396013658 active site 585396013659 HslU subunit interaction site [polypeptide binding]; other site 585396013660 essential cell division protein FtsN; Provisional; Region: PRK10927 585396013661 cell division protein FtsN; Provisional; Region: PRK12757 585396013662 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396013663 DNA binding site [nucleotide binding] 585396013664 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 585396013665 domain linker motif; other site 585396013666 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 585396013667 dimerization interface [polypeptide binding]; other site 585396013668 ligand binding site [chemical binding]; other site 585396013669 primosome assembly protein PriA; Validated; Region: PRK05580 585396013670 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585396013671 ATP binding site [chemical binding]; other site 585396013672 putative Mg++ binding site [ion binding]; other site 585396013673 helicase superfamily c-terminal domain; Region: HELICc; smart00490 585396013674 ATP-binding site [chemical binding]; other site 585396013675 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 585396013676 PAAR motif; Region: PAAR_motif; cl15808 585396013677 RHS Repeat; Region: RHS_repeat; pfam05593 585396013678 RHS Repeat; Region: RHS_repeat; pfam05593 585396013679 RHS Repeat; Region: RHS_repeat; pfam05593 585396013680 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585396013681 RHS Repeat; Region: RHS_repeat; pfam05593 585396013682 RHS Repeat; Region: RHS_repeat; pfam05593 585396013683 RHS protein; Region: RHS; pfam03527 585396013684 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585396013685 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 585396013686 predicted transposase InsB of insertion sequence ISnuxi4, partial 585396013687 hypothetical protein; Provisional; Region: PRK10030 585396013688 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 585396013689 dimerization interface [polypeptide binding]; other site 585396013690 DNA binding site [nucleotide binding] 585396013691 corepressor binding sites; other site 585396013692 cystathionine gamma-synthase; Provisional; Region: PRK08045 585396013693 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 585396013694 homodimer interface [polypeptide binding]; other site 585396013695 substrate-cofactor binding pocket; other site 585396013696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396013697 catalytic residue [active] 585396013698 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 585396013699 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 585396013700 putative catalytic residues [active] 585396013701 putative nucleotide binding site [chemical binding]; other site 585396013702 putative aspartate binding site [chemical binding]; other site 585396013703 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 585396013704 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 585396013705 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 585396013706 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 585396013707 FAD binding site [chemical binding]; other site 585396013708 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 585396013709 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 585396013710 heme binding site [chemical binding]; other site 585396013711 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 585396013712 EamA-like transporter family; Region: EamA; pfam00892 585396013713 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585396013714 EamA-like transporter family; Region: EamA; pfam00892 585396013715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 585396013716 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 585396013717 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 585396013718 dimer interface [polypeptide binding]; other site 585396013719 active site 585396013720 metal binding site [ion binding]; metal-binding site 585396013721 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 585396013722 active site 585396013723 intersubunit interactions; other site 585396013724 catalytic residue [active] 585396013725 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585396013726 dimerization domain swap beta strand [polypeptide binding]; other site 585396013727 regulatory protein interface [polypeptide binding]; other site 585396013728 active site 585396013729 regulatory phosphorylation site [posttranslational modification]; other site 585396013730 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585396013731 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 585396013732 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585396013733 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585396013734 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585396013735 active site 585396013736 phosphorylation site [posttranslational modification] 585396013737 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 585396013738 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 585396013739 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585396013740 active site 585396013741 P-loop; other site 585396013742 phosphorylation site [posttranslational modification] 585396013743 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 585396013744 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 585396013745 dimer interface [polypeptide binding]; other site 585396013746 active site 585396013747 glycine loop; other site 585396013748 pyruvate formate lyase II activase; Provisional; Region: PRK10076 585396013749 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585396013750 active site 585396013751 P-loop; other site 585396013752 phosphorylation site [posttranslational modification] 585396013753 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585396013754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396013755 hypothetical protein; Provisional; Region: PRK10649 585396013756 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585396013757 Sulfatase; Region: Sulfatase; pfam00884 585396013758 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 585396013759 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 585396013760 acetylornithine deacetylase; Provisional; Region: PRK05111 585396013761 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 585396013762 metal binding site [ion binding]; metal-binding site 585396013763 putative dimer interface [polypeptide binding]; other site 585396013764 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 585396013765 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585396013766 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 585396013767 nucleotide binding site [chemical binding]; other site 585396013768 N-acetyl-L-glutamate binding site [chemical binding]; other site 585396013769 argininosuccinate lyase; Provisional; Region: PRK04833 585396013770 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 585396013771 active sites [active] 585396013772 tetramer interface [polypeptide binding]; other site 585396013773 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 585396013774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396013775 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 585396013776 dimerization interface [polypeptide binding]; other site 585396013777 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 585396013778 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396013779 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585396013780 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 585396013781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585396013782 hypothetical protein; Provisional; Region: PRK11056 585396013783 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 585396013784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396013785 S-adenosylmethionine binding site [chemical binding]; other site 585396013786 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 585396013787 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585396013788 N-terminal plug; other site 585396013789 ligand-binding site [chemical binding]; other site 585396013790 glutamate racemase; Provisional; Region: PRK00865 585396013791 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 585396013792 FAD binding domain; Region: FAD_binding_4; pfam01565 585396013793 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 585396013794 Biotin operon repressor [Transcription]; Region: BirA; COG1654 585396013795 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 585396013796 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 585396013797 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 585396013798 pantothenate kinase; Provisional; Region: PRK05439 585396013799 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 585396013800 ATP-binding site [chemical binding]; other site 585396013801 CoA-binding site [chemical binding]; other site 585396013802 Mg2+-binding site [ion binding]; other site 585396013803 elongation factor Tu; Reviewed; Region: PRK00049 585396013804 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 585396013805 G1 box; other site 585396013806 GEF interaction site [polypeptide binding]; other site 585396013807 GTP/Mg2+ binding site [chemical binding]; other site 585396013808 Switch I region; other site 585396013809 G2 box; other site 585396013810 G3 box; other site 585396013811 Switch II region; other site 585396013812 G4 box; other site 585396013813 G5 box; other site 585396013814 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 585396013815 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 585396013816 Antibiotic Binding Site [chemical binding]; other site 585396013817 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 585396013818 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 585396013819 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 585396013820 putative homodimer interface [polypeptide binding]; other site 585396013821 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 585396013822 heterodimer interface [polypeptide binding]; other site 585396013823 homodimer interface [polypeptide binding]; other site 585396013824 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 585396013825 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 585396013826 23S rRNA interface [nucleotide binding]; other site 585396013827 L7/L12 interface [polypeptide binding]; other site 585396013828 putative thiostrepton binding site; other site 585396013829 L25 interface [polypeptide binding]; other site 585396013830 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 585396013831 mRNA/rRNA interface [nucleotide binding]; other site 585396013832 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 585396013833 23S rRNA interface [nucleotide binding]; other site 585396013834 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 585396013835 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 585396013836 core dimer interface [polypeptide binding]; other site 585396013837 peripheral dimer interface [polypeptide binding]; other site 585396013838 L10 interface [polypeptide binding]; other site 585396013839 L11 interface [polypeptide binding]; other site 585396013840 putative EF-Tu interaction site [polypeptide binding]; other site 585396013841 putative EF-G interaction site [polypeptide binding]; other site 585396013842 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 585396013843 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 585396013844 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 585396013845 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 585396013846 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 585396013847 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 585396013848 RPB3 interaction site [polypeptide binding]; other site 585396013849 RPB1 interaction site [polypeptide binding]; other site 585396013850 RPB11 interaction site [polypeptide binding]; other site 585396013851 RPB10 interaction site [polypeptide binding]; other site 585396013852 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 585396013853 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 585396013854 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 585396013855 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 585396013856 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 585396013857 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 585396013858 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 585396013859 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 585396013860 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 585396013861 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 585396013862 DNA binding site [nucleotide binding] 585396013863 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 585396013864 heat shock protein HtrC, N-terminal part 585396013865 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 585396013866 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396013867 FeS/SAM binding site; other site 585396013868 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 585396013869 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 585396013870 ThiS interaction site; other site 585396013871 putative active site [active] 585396013872 tetramer interface [polypeptide binding]; other site 585396013873 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 585396013874 thiS-thiF/thiG interaction site; other site 585396013875 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 585396013876 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 585396013877 ATP binding site [chemical binding]; other site 585396013878 substrate interface [chemical binding]; other site 585396013879 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 585396013880 thiamine phosphate binding site [chemical binding]; other site 585396013881 active site 585396013882 pyrophosphate binding site [ion binding]; other site 585396013883 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 585396013884 ThiC-associated domain; Region: ThiC-associated; pfam13667 585396013885 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 585396013886 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 585396013887 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 585396013888 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 585396013889 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 585396013890 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 585396013891 putative NADH binding site [chemical binding]; other site 585396013892 putative active site [active] 585396013893 nudix motif; other site 585396013894 putative metal binding site [ion binding]; other site 585396013895 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 585396013896 substrate binding site [chemical binding]; other site 585396013897 active site 585396013898 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 585396013899 Active_site [active] 585396013900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 585396013901 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585396013902 IHF dimer interface [polypeptide binding]; other site 585396013903 IHF - DNA interface [nucleotide binding]; other site 585396013904 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 585396013905 zinc resistance protein; Provisional; Region: zraP; PRK11546 585396013906 dimer interface [polypeptide binding]; other site 585396013907 sensor protein ZraS; Provisional; Region: PRK10364 585396013908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396013909 dimer interface [polypeptide binding]; other site 585396013910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396013911 ATP binding site [chemical binding]; other site 585396013912 Mg2+ binding site [ion binding]; other site 585396013913 G-X-G motif; other site 585396013914 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 585396013915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396013916 active site 585396013917 phosphorylation site [posttranslational modification] 585396013918 intermolecular recognition site; other site 585396013919 dimerization interface [polypeptide binding]; other site 585396013920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396013921 Walker A motif; other site 585396013922 ATP binding site [chemical binding]; other site 585396013923 Walker B motif; other site 585396013924 arginine finger; other site 585396013925 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585396013926 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 585396013927 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 585396013928 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 585396013929 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 585396013930 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 585396013931 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 585396013932 purine monophosphate binding site [chemical binding]; other site 585396013933 dimer interface [polypeptide binding]; other site 585396013934 putative catalytic residues [active] 585396013935 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 585396013936 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585396013937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396013938 Coenzyme A binding pocket [chemical binding]; other site 585396013939 homoserine O-succinyltransferase; Provisional; Region: PRK05368 585396013940 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 585396013941 proposed active site lysine [active] 585396013942 conserved cys residue [active] 585396013943 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 585396013944 malate synthase A; Region: malate_syn_A; TIGR01344 585396013945 active site 585396013946 isocitrate lyase; Provisional; Region: PRK15063 585396013947 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 585396013948 tetramer interface [polypeptide binding]; other site 585396013949 active site 585396013950 Mg2+/Mn2+ binding site [ion binding]; other site 585396013951 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 585396013952 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 585396013953 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 585396013954 transcriptional repressor IclR; Provisional; Region: PRK11569 585396013955 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585396013956 Bacterial transcriptional regulator; Region: IclR; pfam01614 585396013957 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 585396013958 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 585396013959 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 585396013960 substrate binding pocket [chemical binding]; other site 585396013961 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 585396013962 B12 binding site [chemical binding]; other site 585396013963 cobalt ligand [ion binding]; other site 585396013964 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 585396013965 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 585396013966 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 585396013967 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 585396013968 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 585396013969 active site pocket [active] 585396013970 oxyanion hole [active] 585396013971 catalytic triad [active] 585396013972 active site nucleophile [active] 585396013973 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 585396013974 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585396013975 putative NAD(P) binding site [chemical binding]; other site 585396013976 catalytic Zn binding site [ion binding]; other site 585396013977 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 585396013978 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 585396013979 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585396013980 active site 585396013981 phosphorylation site [posttranslational modification] 585396013982 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585396013983 active pocket/dimerization site; other site 585396013984 active site 585396013985 phosphorylation site [posttranslational modification] 585396013986 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 585396013987 classical (c) SDRs; Region: SDR_c; cd05233 585396013988 NAD(P) binding site [chemical binding]; other site 585396013989 active site 585396013990 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 585396013991 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585396013992 putative DNA binding site [nucleotide binding]; other site 585396013993 putative Zn2+ binding site [ion binding]; other site 585396013994 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 585396013995 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 585396013996 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585396013997 RNA binding surface [nucleotide binding]; other site 585396013998 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 585396013999 probable active site [active] 585396014000 hypothetical protein; Provisional; Region: PRK10515 585396014001 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 585396014002 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 585396014003 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 585396014004 Zeta toxin; Region: Zeta_toxin; pfam06414 585396014005 aspartate kinase III; Validated; Region: PRK09084 585396014006 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 585396014007 nucleotide binding site [chemical binding]; other site 585396014008 putative catalytic residues [active] 585396014009 aspartate binding site [chemical binding]; other site 585396014010 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 585396014011 lysine allosteric regulatory site; other site 585396014012 dimer interface [polypeptide binding]; other site 585396014013 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 585396014014 dimer interface [polypeptide binding]; other site 585396014015 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 585396014016 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 585396014017 active site 585396014018 dimer interface [polypeptide binding]; other site 585396014019 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 585396014020 dimer interface [polypeptide binding]; other site 585396014021 active site 585396014022 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 585396014023 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 585396014024 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 585396014025 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 585396014026 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 585396014027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396014028 putative substrate translocation pore; other site 585396014029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396014030 part of maltose permease MalG, inner membrane; membrane component of ABC superfamily 585396014031 part of maltose permease MalF, periplasmic; membrane component of ABC superfamily 585396014032 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 585396014033 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 585396014034 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 585396014035 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 585396014036 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585396014037 Walker A/P-loop; other site 585396014038 ATP binding site [chemical binding]; other site 585396014039 Q-loop/lid; other site 585396014040 ABC transporter signature motif; other site 585396014041 Walker B; other site 585396014042 D-loop; other site 585396014043 H-loop/switch region; other site 585396014044 TOBE domain; Region: TOBE_2; pfam08402 585396014045 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585396014046 trimer interface; other site 585396014047 sugar binding site [chemical binding]; other site 585396014048 maltose regulon periplasmic protein; Provisional; Region: PRK10564 585396014049 T3SS effector-like protein, EspX-homolog, N-terminal fragment 585396014050 T3SS effector-like protein, EspX-homolog, C-terminal fragment 585396014051 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 585396014052 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 585396014053 UbiA prenyltransferase family; Region: UbiA; pfam01040 585396014054 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 585396014055 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 585396014056 putative acyl-acceptor binding pocket; other site 585396014057 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 585396014058 LexA repressor; Validated; Region: PRK00215 585396014059 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 585396014060 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585396014061 Catalytic site [active] 585396014062 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 585396014063 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 585396014064 hypothetical protein; Provisional; Region: PRK10428 585396014065 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 585396014066 metal binding site 2 [ion binding]; metal-binding site 585396014067 putative DNA binding helix; other site 585396014068 metal binding site 1 [ion binding]; metal-binding site 585396014069 dimer interface [polypeptide binding]; other site 585396014070 structural Zn2+ binding site [ion binding]; other site 585396014071 conserved predicted protein, C-terminal fragment 585396014072 Prophage ECO111_P17, lambda-like phage 585396014073 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 585396014074 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 585396014075 active site 585396014076 substrate binding site [chemical binding]; other site 585396014077 catalytic site [active] 585396014078 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585396014079 Methyltransferase domain; Region: Methyltransf_25; pfam13649 585396014080 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 585396014081 Uncharacterized conserved protein [Function unknown]; Region: COG5532 585396014082 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585396014083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396014084 non-specific DNA binding site [nucleotide binding]; other site 585396014085 salt bridge; other site 585396014086 sequence-specific DNA binding site [nucleotide binding]; other site 585396014087 Predicted transcriptional regulator [Transcription]; Region: COG2932 585396014088 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585396014089 Catalytic site [active] 585396014090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396014091 non-specific DNA binding site [nucleotide binding]; other site 585396014092 salt bridge; other site 585396014093 sequence-specific DNA binding site [nucleotide binding]; other site 585396014094 Prophage ECO111_P17; putative transposase OrfB protein of insertion sequence IS629, C-terminal fragment 585396014095 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585396014096 Antitermination protein; Region: Antiterm; pfam03589 585396014097 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 585396014098 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585396014099 Zn binding sites [ion binding]; other site 585396014100 Antitermination protein; Region: Antiterm; pfam03589 585396014101 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585396014102 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585396014103 Lysis protein S; Region: Lysis_S; pfam04971 585396014104 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585396014105 catalytic residues [active] 585396014106 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585396014107 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 585396014108 PerC transcriptional activator; Region: PerC; pfam06069 585396014109 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 585396014110 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585396014111 active site 585396014112 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 585396014113 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 585396014114 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 585396014115 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 585396014116 Phage capsid family; Region: Phage_capsid; pfam05065 585396014117 Phage-related protein [Function unknown]; Region: COG4695 585396014118 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 585396014119 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 585396014120 zinc binding site [ion binding]; other site 585396014121 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 585396014122 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 585396014123 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 585396014124 Immunoglobulin I-set domain; Region: I-set; pfam07679 585396014125 Immunoglobulin domain; Region: Ig_2; pfam13895 585396014126 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 585396014127 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 585396014128 Phage-related minor tail protein [Function unknown]; Region: COG5281 585396014129 tape measure domain; Region: tape_meas_nterm; TIGR02675 585396014130 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 585396014131 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585396014132 Phage-related protein [Function unknown]; Region: COG4718 585396014133 Phage-related protein [Function unknown]; Region: gp18; COG4672 585396014134 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585396014135 MPN+ (JAMM) motif; other site 585396014136 Zinc-binding site [ion binding]; other site 585396014137 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585396014138 NlpC/P60 family; Region: NLPC_P60; cl17555 585396014139 Phage-related protein, tail component [Function unknown]; Region: COG4723 585396014140 Phage-related protein, tail component [Function unknown]; Region: COG4733 585396014141 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585396014142 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585396014143 Interdomain contacts; other site 585396014144 Cytokine receptor motif; other site 585396014145 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585396014146 Fibronectin type III protein; Region: DUF3672; pfam12421 585396014147 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585396014148 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585396014149 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 585396014150 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396014151 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 585396014152 Prophage ECO111_P17; T3SS secreted effector NleG-like protein, C-terminal part 585396014153 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 585396014154 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 585396014155 DinI-like family; Region: DinI; pfam06183 585396014156 Prophage ECO111_P17; predicted integrase, C-terminal fragment 585396014157 Prophage ECO111_P17; predicted integrase, N-terminal fragment 585396014158 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 585396014159 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585396014160 FMN binding site [chemical binding]; other site 585396014161 active site 585396014162 catalytic residues [active] 585396014163 substrate binding site [chemical binding]; other site 585396014164 phage shock protein G; Reviewed; Region: pspG; PRK09459 585396014165 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 585396014166 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 585396014167 NADP binding site [chemical binding]; other site 585396014168 dimer interface [polypeptide binding]; other site 585396014169 replicative DNA helicase; Provisional; Region: PRK08006 585396014170 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 585396014171 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 585396014172 Walker A motif; other site 585396014173 ATP binding site [chemical binding]; other site 585396014174 Walker B motif; other site 585396014175 DNA binding loops [nucleotide binding] 585396014176 alanine racemase; Reviewed; Region: alr; PRK00053 585396014177 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 585396014178 active site 585396014179 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585396014180 substrate binding site [chemical binding]; other site 585396014181 catalytic residues [active] 585396014182 dimer interface [polypeptide binding]; other site 585396014183 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 585396014184 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585396014185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396014186 homodimer interface [polypeptide binding]; other site 585396014187 catalytic residue [active] 585396014188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396014189 active site 585396014190 motif I; other site 585396014191 motif II; other site 585396014192 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 585396014193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 585396014194 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 585396014195 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 585396014196 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 585396014197 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 585396014198 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 585396014199 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585396014200 dimer interface [polypeptide binding]; other site 585396014201 ssDNA binding site [nucleotide binding]; other site 585396014202 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585396014203 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 585396014204 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 585396014205 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585396014206 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396014207 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 585396014208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396014209 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 585396014210 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 585396014211 DNA binding residues [nucleotide binding] 585396014212 dimer interface [polypeptide binding]; other site 585396014213 [2Fe-2S] cluster binding site [ion binding]; other site 585396014214 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585396014215 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 585396014216 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 585396014217 T3SS effector-like protein EspX-homolog, C-terminal 585396014218 T3SS effector-like protein EspX-homolog, N-terminal 585396014219 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 585396014220 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 585396014221 Na binding site [ion binding]; other site 585396014222 Predicted membrane protein [Function unknown]; Region: COG3162 585396014223 acetyl-CoA synthetase; Provisional; Region: PRK00174 585396014224 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 585396014225 active site 585396014226 CoA binding site [chemical binding]; other site 585396014227 acyl-activating enzyme (AAE) consensus motif; other site 585396014228 AMP binding site [chemical binding]; other site 585396014229 acetate binding site [chemical binding]; other site 585396014230 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 585396014231 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 585396014232 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 585396014233 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 585396014234 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 585396014235 heme lyase subunit NrfE; Provisional; Region: PRK10369 585396014236 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 585396014237 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 585396014238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585396014239 binding surface 585396014240 TPR motif; other site 585396014241 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 585396014242 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585396014243 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585396014244 Sel1-like repeats; Region: SEL1; smart00671 585396014245 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 585396014246 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 585396014247 [4Fe-4S] binding site [ion binding]; other site 585396014248 molybdopterin cofactor binding site; other site 585396014249 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 585396014250 molybdopterin cofactor binding site; other site 585396014251 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 585396014252 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 585396014253 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585396014254 multidrug resistance protein MdtN; Provisional; Region: PRK10476 585396014255 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585396014256 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396014257 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 585396014258 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 585396014259 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 585396014260 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 585396014261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396014262 Coenzyme A binding pocket [chemical binding]; other site 585396014263 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 585396014264 AAA domain; Region: AAA_18; pfam13238 585396014265 active site 585396014266 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 585396014267 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 585396014268 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 585396014269 active site 585396014270 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 585396014271 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585396014272 Walker A/P-loop; other site 585396014273 ATP binding site [chemical binding]; other site 585396014274 Q-loop/lid; other site 585396014275 ABC transporter signature motif; other site 585396014276 Walker B; other site 585396014277 D-loop; other site 585396014278 H-loop/switch region; other site 585396014279 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 585396014280 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585396014281 Walker A/P-loop; other site 585396014282 ATP binding site [chemical binding]; other site 585396014283 Q-loop/lid; other site 585396014284 ABC transporter signature motif; other site 585396014285 Walker B; other site 585396014286 D-loop; other site 585396014287 H-loop/switch region; other site 585396014288 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585396014289 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 585396014290 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 585396014291 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 585396014292 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 585396014293 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 585396014294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396014295 DNA-binding site [nucleotide binding]; DNA binding site 585396014296 UTRA domain; Region: UTRA; pfam07702 585396014297 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 585396014298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585396014299 dimer interface [polypeptide binding]; other site 585396014300 conserved gate region; other site 585396014301 putative PBP binding loops; other site 585396014302 ABC-ATPase subunit interface; other site 585396014303 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 585396014304 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585396014305 substrate binding pocket [chemical binding]; other site 585396014306 membrane-bound complex binding site; other site 585396014307 hinge residues; other site 585396014308 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 585396014309 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 585396014310 Walker A/P-loop; other site 585396014311 ATP binding site [chemical binding]; other site 585396014312 Q-loop/lid; other site 585396014313 ABC transporter signature motif; other site 585396014314 Walker B; other site 585396014315 D-loop; other site 585396014316 H-loop/switch region; other site 585396014317 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 585396014318 dimer interface [polypeptide binding]; other site 585396014319 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585396014320 hypothetical protein; Provisional; Region: PRK10220 585396014321 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 585396014322 PhnA protein; Region: PhnA; pfam03831 585396014323 hypothetical protein; Provisional; Region: PRK09866 585396014324 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585396014325 G1 box; other site 585396014326 GTP/Mg2+ binding site [chemical binding]; other site 585396014327 G2 box; other site 585396014328 Switch I region; other site 585396014329 G3 box; other site 585396014330 Switch II region; other site 585396014331 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 585396014332 G2 box; other site 585396014333 Switch I region; other site 585396014334 G3 box; other site 585396014335 Switch II region; other site 585396014336 G4 box; other site 585396014337 G5 box; other site 585396014338 YjcZ-like protein; Region: YjcZ; pfam13990 585396014339 proline/glycine betaine transporter; Provisional; Region: PRK10642 585396014340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396014341 putative substrate translocation pore; other site 585396014342 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 585396014343 sensor protein BasS/PmrB; Provisional; Region: PRK10755 585396014344 HAMP domain; Region: HAMP; pfam00672 585396014345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396014346 dimer interface [polypeptide binding]; other site 585396014347 phosphorylation site [posttranslational modification] 585396014348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396014349 ATP binding site [chemical binding]; other site 585396014350 Mg2+ binding site [ion binding]; other site 585396014351 G-X-G motif; other site 585396014352 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 585396014353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396014354 active site 585396014355 phosphorylation site [posttranslational modification] 585396014356 intermolecular recognition site; other site 585396014357 dimerization interface [polypeptide binding]; other site 585396014358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396014359 DNA binding site [nucleotide binding] 585396014360 putative metal dependent hydrolase; Provisional; Region: PRK11598 585396014361 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585396014362 Sulfatase; Region: Sulfatase; pfam00884 585396014363 arginine:agmatin antiporter; Provisional; Region: PRK10644 585396014364 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585396014365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396014366 arginine decarboxylase; Provisional; Region: PRK15029 585396014367 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585396014368 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585396014369 homodimer interface [polypeptide binding]; other site 585396014370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396014371 catalytic residue [active] 585396014372 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585396014373 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 585396014374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396014375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396014376 alpha-galactosidase; Provisional; Region: PRK15076 585396014377 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 585396014378 NAD binding site [chemical binding]; other site 585396014379 sugar binding site [chemical binding]; other site 585396014380 divalent metal binding site [ion binding]; other site 585396014381 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 585396014382 dimer interface [polypeptide binding]; other site 585396014383 melibiose:sodium symporter; Provisional; Region: PRK10429 585396014384 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 585396014385 hypothetical protein; Provisional; Region: PRK09867 585396014386 fumarate hydratase; Provisional; Region: PRK15389 585396014387 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 585396014388 Fumarase C-terminus; Region: Fumerase_C; pfam05683 585396014389 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 585396014390 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 585396014391 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 585396014392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396014393 active site 585396014394 phosphorylation site [posttranslational modification] 585396014395 intermolecular recognition site; other site 585396014396 dimerization interface [polypeptide binding]; other site 585396014397 Transcriptional regulator; Region: CitT; pfam12431 585396014398 sensory histidine kinase DcuS; Provisional; Region: PRK11086 585396014399 PAS domain; Region: PAS; smart00091 585396014400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396014401 ATP binding site [chemical binding]; other site 585396014402 Mg2+ binding site [ion binding]; other site 585396014403 G-X-G motif; other site 585396014404 Uncharacterized conserved protein [Function unknown]; Region: COG3592 585396014405 Predicted acetyltransferase [General function prediction only]; Region: COG2388 585396014406 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 585396014407 lysine tRNA synthetase LysU, truncated 585396014408 Integrative element ECO111_IE06a 585396014409 Transposase; Region: HTH_Tnp_1; cl17663 585396014410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396014411 putative transposase OrfB; Reviewed; Region: PHA02517 585396014412 HTH-like domain; Region: HTH_21; pfam13276 585396014413 Integrase core domain; Region: rve; pfam00665 585396014414 Integrase core domain; Region: rve_3; pfam13683 585396014415 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 585396014416 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 585396014417 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 585396014418 cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586 585396014419 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 585396014420 Integrative element ECO111_IE06a; predicted transposase of insertion sequence IS630, partial 585396014421 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 585396014422 type III secretion system protein; Provisional; Region: PRK15384; cl14665 585396014423 Integrative element ECO111_IE06a; T3SS secreted effector EspL-like protein, C-terminal fragment 585396014424 Integrative element ECO111_IE06a; T3SS secreted effector EspL-like protein, N-terminal fragment 585396014425 Integrative element ECO111_IE06a; putative transposase TnpB of insertion sequence IS609, N-terminal fragment 585396014426 Transposase IS200 like; Region: Y1_Tnp; pfam01797 585396014427 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 585396014428 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 585396014429 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 585396014430 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 585396014431 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 585396014432 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585396014433 dimer interface [polypeptide binding]; other site 585396014434 ssDNA binding site [nucleotide binding]; other site 585396014435 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585396014436 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 585396014437 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585396014438 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585396014439 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585396014440 intersubunit interface [polypeptide binding]; other site 585396014441 active site 585396014442 Zn2+ binding site [ion binding]; other site 585396014443 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 585396014444 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585396014445 AP (apurinic/apyrimidinic) site pocket; other site 585396014446 DNA interaction; other site 585396014447 Metal-binding active site; metal-binding site 585396014448 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 585396014449 active site 585396014450 dimer interface [polypeptide binding]; other site 585396014451 magnesium binding site [ion binding]; other site 585396014452 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585396014453 active site 585396014454 phosphorylation site [posttranslational modification] 585396014455 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 585396014456 active site 585396014457 P-loop; other site 585396014458 phosphorylation site [posttranslational modification] 585396014459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 585396014460 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 585396014461 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 585396014462 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 585396014463 transcriptional repressor UlaR; Provisional; Region: PRK13509 585396014464 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585396014465 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585396014466 esterase; Provisional; Region: PRK10566 585396014467 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585396014468 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585396014469 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 585396014470 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585396014471 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 585396014472 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 585396014473 FAD binding site [chemical binding]; other site 585396014474 substrate binding site [chemical binding]; other site 585396014475 catalytic residues [active] 585396014476 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585396014477 Predicted integral membrane protein [Function unknown]; Region: COG5463 585396014478 Predicted membrane protein [Function unknown]; Region: COG3766 585396014479 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 585396014480 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 585396014481 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 585396014482 PspA/IM30 family; Region: PspA_IM30; pfam04012 585396014483 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 585396014484 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 585396014485 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 585396014486 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585396014487 exoribonuclease R; Provisional; Region: PRK11642 585396014488 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 585396014489 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 585396014490 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 585396014491 RNB domain; Region: RNB; pfam00773 585396014492 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 585396014493 RNA binding site [nucleotide binding]; other site 585396014494 Predicted transcriptional regulator [Transcription]; Region: COG1959 585396014495 transcriptional repressor NsrR; Provisional; Region: PRK11014 585396014496 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 585396014497 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 585396014498 GDP-binding site [chemical binding]; other site 585396014499 ACT binding site; other site 585396014500 IMP binding site; other site 585396014501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 585396014502 FtsH protease regulator HflC; Provisional; Region: PRK11029 585396014503 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 585396014504 FtsH protease regulator HflK; Provisional; Region: PRK10930 585396014505 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 585396014506 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 585396014507 GTPase HflX; Provisional; Region: PRK11058 585396014508 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 585396014509 HflX GTPase family; Region: HflX; cd01878 585396014510 G1 box; other site 585396014511 GTP/Mg2+ binding site [chemical binding]; other site 585396014512 Switch I region; other site 585396014513 G2 box; other site 585396014514 G3 box; other site 585396014515 Switch II region; other site 585396014516 G4 box; other site 585396014517 G5 box; other site 585396014518 bacterial Hfq-like; Region: Hfq; cd01716 585396014519 hexamer interface [polypeptide binding]; other site 585396014520 Sm1 motif; other site 585396014521 RNA binding site [nucleotide binding]; other site 585396014522 Sm2 motif; other site 585396014523 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 585396014524 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 585396014525 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 585396014526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396014527 ATP binding site [chemical binding]; other site 585396014528 Mg2+ binding site [ion binding]; other site 585396014529 G-X-G motif; other site 585396014530 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 585396014531 ATP binding site [chemical binding]; other site 585396014532 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 585396014533 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 585396014534 AMIN domain; Region: AMIN; pfam11741 585396014535 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585396014536 active site 585396014537 metal binding site [ion binding]; metal-binding site 585396014538 ADP-binding protein; Provisional; Region: PRK10646 585396014539 putative carbohydrate kinase; Provisional; Region: PRK10565 585396014540 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 585396014541 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 585396014542 putative substrate binding site [chemical binding]; other site 585396014543 putative ATP binding site [chemical binding]; other site 585396014544 epoxyqueuosine reductase; Region: TIGR00276 585396014545 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 585396014546 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 585396014547 catalytic site [active] 585396014548 putative active site [active] 585396014549 putative substrate binding site [chemical binding]; other site 585396014550 dimer interface [polypeptide binding]; other site 585396014551 GTPase RsgA; Reviewed; Region: PRK12288 585396014552 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 585396014553 RNA binding site [nucleotide binding]; other site 585396014554 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 585396014555 GTPase/Zn-binding domain interface [polypeptide binding]; other site 585396014556 GTP/Mg2+ binding site [chemical binding]; other site 585396014557 G4 box; other site 585396014558 G5 box; other site 585396014559 G1 box; other site 585396014560 Switch I region; other site 585396014561 G2 box; other site 585396014562 G3 box; other site 585396014563 Switch II region; other site 585396014564 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 585396014565 putative mechanosensitive channel protein; Provisional; Region: PRK10929 585396014566 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 585396014567 DNA-binding site [nucleotide binding]; DNA binding site 585396014568 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 585396014569 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585396014570 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 585396014571 inner membrane transporter YjeM; Provisional; Region: PRK15238 585396014572 poxB regulator PoxA; Provisional; Region: PRK09350 585396014573 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 585396014574 motif 1; other site 585396014575 dimer interface [polypeptide binding]; other site 585396014576 active site 585396014577 motif 2; other site 585396014578 motif 3; other site 585396014579 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 585396014580 L-aspartate oxidase; Provisional; Region: PRK06175 585396014581 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585396014582 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 585396014583 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 585396014584 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 585396014585 D-subunit interface [polypeptide binding]; other site 585396014586 Iron-sulfur protein interface; other site 585396014587 proximal quinone binding site [chemical binding]; other site 585396014588 distal quinone binding site [chemical binding]; other site 585396014589 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 585396014590 Iron-sulfur protein interface; other site 585396014591 proximal quinone binding site [chemical binding]; other site 585396014592 C-subunit interface; other site 585396014593 distal quinone binding site; other site 585396014594 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 585396014595 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585396014596 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 585396014597 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 585396014598 multidrug efflux system protein; Provisional; Region: PRK11431 585396014599 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 585396014600 entericidin A; Provisional; Region: PRK09810 585396014601 elongation factor P; Validated; Region: PRK00529 585396014602 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 585396014603 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 585396014604 RNA binding site [nucleotide binding]; other site 585396014605 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 585396014606 RNA binding site [nucleotide binding]; other site 585396014607 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 585396014608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396014609 FeS/SAM binding site; other site 585396014610 excinuclease ABC subunit B; Provisional; Region: PRK05298 585396014611 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 585396014612 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 585396014613 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 585396014614 ring oligomerisation interface [polypeptide binding]; other site 585396014615 ATP/Mg binding site [chemical binding]; other site 585396014616 stacking interactions; other site 585396014617 hinge regions; other site 585396014618 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 585396014619 oligomerisation interface [polypeptide binding]; other site 585396014620 mobile loop; other site 585396014621 roof hairpin; other site 585396014622 putative transporter; Provisional; Region: PRK11021 585396014623 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 585396014624 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 585396014625 Aspartase; Region: Aspartase; cd01357 585396014626 active sites [active] 585396014627 tetramer interface [polypeptide binding]; other site 585396014628 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 585396014629 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 585396014630 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 585396014631 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 585396014632 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 585396014633 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 585396014634 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 585396014635 DsbD alpha interface [polypeptide binding]; other site 585396014636 catalytic residues [active] 585396014637 putative transcriptional regulator; Provisional; Region: PRK11640 585396014638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585396014639 Integrative element ECO111_IE06b 585396014640 integrase; Provisional; Region: PRK09692 585396014641 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585396014642 active site 585396014643 Int/Topo IB signature motif; other site 585396014644 Integrative element ECO111_IE06b; predicted protein Orf3 in insertion sequence ISEc8, C-terminal fragment 585396014645 Integrative element ECO111_IE06b; predicted protein Orf1 in insertion sequence IS683, N-terminal fragment 585396014646 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585396014647 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585396014648 Integrative element ECO111_IE06b; predicted protein Orf3 in insertion sequence IS683, partial 585396014649 Integrative element ECO111_IE06b; predicted helicase, N-terminal fragment 585396014650 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585396014651 Integrative element ECO111_IE06b; predicted transposase of insertion sequence IS608, N-terminal fragment 585396014652 putative transposase OrfB; Reviewed; Region: PHA02517 585396014653 HTH-like domain; Region: HTH_21; pfam13276 585396014654 Integrase core domain; Region: rve; pfam00665 585396014655 Integrase core domain; Region: rve_3; pfam13683 585396014656 Transposase; Region: HTH_Tnp_1; cl17663 585396014657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396014658 putative transposase TnpB of insertion sequence IS609, C-terminal fragment 585396014659 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 585396014660 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 585396014661 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 585396014662 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 585396014663 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585396014664 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 585396014665 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 585396014666 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 585396014667 Hemerythrin-like domain; Region: Hr-like; cd12108 585396014668 Fe binding site [ion binding]; other site 585396014669 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 585396014670 EamA-like transporter family; Region: EamA; pfam00892 585396014671 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 585396014672 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 585396014673 NADP binding site [chemical binding]; other site 585396014674 Predicted transcriptional regulators [Transcription]; Region: COG1733 585396014675 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 585396014676 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 585396014677 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 585396014678 active site 585396014679 metal binding site [ion binding]; metal-binding site 585396014680 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585396014681 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 585396014682 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 585396014683 active site 585396014684 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 585396014685 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 585396014686 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 585396014687 Domain of unknown function DUF21; Region: DUF21; pfam01595 585396014688 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585396014689 Transporter associated domain; Region: CorC_HlyC; smart01091 585396014690 methionine sulfoxide reductase A; Provisional; Region: PRK00058 585396014691 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 585396014692 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585396014693 Surface antigen; Region: Bac_surface_Ag; pfam01103 585396014694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 585396014695 Family of unknown function (DUF490); Region: DUF490; pfam04357 585396014696 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 585396014697 putative active site pocket [active] 585396014698 dimerization interface [polypeptide binding]; other site 585396014699 putative catalytic residue [active] 585396014700 antitoxin ChpS; Provisional; Region: PRK11347 585396014701 toxin ChpB; Provisional; Region: PRK09812 585396014702 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 585396014703 dimer interface [polypeptide binding]; other site 585396014704 substrate binding site [chemical binding]; other site 585396014705 metal binding sites [ion binding]; metal-binding site 585396014706 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 585396014707 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 585396014708 putative ligand binding site [chemical binding]; other site 585396014709 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585396014710 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585396014711 Walker A/P-loop; other site 585396014712 ATP binding site [chemical binding]; other site 585396014713 Q-loop/lid; other site 585396014714 ABC transporter signature motif; other site 585396014715 Walker B; other site 585396014716 D-loop; other site 585396014717 H-loop/switch region; other site 585396014718 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585396014719 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585396014720 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585396014721 TM-ABC transporter signature motif; other site 585396014722 predicted sugar transporter subunit: membrane component of ABC superfamily, truncated 585396014723 predicted sugar transporter subunit: membrane component of ABC superfamily, C-terminal 585396014724 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 585396014725 AMP binding site [chemical binding]; other site 585396014726 metal binding site [ion binding]; metal-binding site 585396014727 active site 585396014728 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 585396014729 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585396014730 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585396014731 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585396014732 hypothetical protein; Provisional; Region: PRK05255 585396014733 peptidase PmbA; Provisional; Region: PRK11040 585396014734 cytochrome b562; Provisional; Region: PRK15058 585396014735 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 585396014736 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396014737 FeS/SAM binding site; other site 585396014738 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 585396014739 ATP cone domain; Region: ATP-cone; pfam03477 585396014740 Class III ribonucleotide reductase; Region: RNR_III; cd01675 585396014741 effector binding site; other site 585396014742 active site 585396014743 Zn binding site [ion binding]; other site 585396014744 glycine loop; other site 585396014745 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 585396014746 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 585396014747 Ca binding site [ion binding]; other site 585396014748 active site 585396014749 catalytic site [active] 585396014750 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 585396014751 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585396014752 active site turn [active] 585396014753 phosphorylation site [posttranslational modification] 585396014754 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585396014755 trehalose repressor; Provisional; Region: treR; PRK09492 585396014756 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585396014757 DNA binding site [nucleotide binding] 585396014758 domain linker motif; other site 585396014759 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 585396014760 dimerization interface [polypeptide binding]; other site 585396014761 ligand binding site [chemical binding]; other site 585396014762 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 585396014763 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 585396014764 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585396014765 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 585396014766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396014767 motif II; other site 585396014768 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 585396014769 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585396014770 homotrimer interaction site [polypeptide binding]; other site 585396014771 putative active site [active] 585396014772 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 585396014773 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 585396014774 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 585396014775 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 585396014776 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585396014777 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585396014778 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 585396014779 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 585396014780 homotrimer interaction site [polypeptide binding]; other site 585396014781 putative active site [active] 585396014782 oxidoreductase; Provisional; Region: PRK12742 585396014783 classical (c) SDRs; Region: SDR_c; cd05233 585396014784 NAD(P) binding site [chemical binding]; other site 585396014785 active site 585396014786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585396014787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585396014788 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 585396014789 conserved predicted protein, N-terminal part 585396014790 conserved predicted protein, C-terminal part 585396014791 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 585396014792 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585396014793 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585396014794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 585396014795 RNase E inhibitor protein; Provisional; Region: PRK11191 585396014796 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 585396014797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396014798 Coenzyme A binding pocket [chemical binding]; other site 585396014799 Predicted membrane protein [Function unknown]; Region: COG4269 585396014800 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 585396014801 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 585396014802 HIGH motif; other site 585396014803 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 585396014804 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 585396014805 active site 585396014806 KMSKS motif; other site 585396014807 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 585396014808 tRNA binding surface [nucleotide binding]; other site 585396014809 anticodon binding site; other site 585396014810 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 585396014811 DNA polymerase III subunit chi; Validated; Region: PRK05728 585396014812 multifunctional aminopeptidase A; Provisional; Region: PRK00913 585396014813 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 585396014814 interface (dimer of trimers) [polypeptide binding]; other site 585396014815 Substrate-binding/catalytic site; other site 585396014816 Zn-binding sites [ion binding]; other site 585396014817 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 585396014818 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585396014819 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 585396014820 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585396014821 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 585396014822 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 585396014823 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 585396014824 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 585396014825 putative NAD(P) binding site [chemical binding]; other site 585396014826 putative substrate binding site [chemical binding]; other site 585396014827 catalytic Zn binding site [ion binding]; other site 585396014828 structural Zn binding site [ion binding]; other site 585396014829 dimer interface [polypeptide binding]; other site 585396014830 Integrative element ECO111_IE07 585396014831 Integrative element ECO111_IE07; putative integrase, truncated 585396014832 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 585396014833 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 585396014834 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 585396014835 PLD-like domain; Region: PLDc_2; pfam13091 585396014836 homodimer interface [polypeptide binding]; other site 585396014837 putative active site [active] 585396014838 catalytic site [active] 585396014839 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 585396014840 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 585396014841 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 585396014842 TIGR02687 family protein; Region: TIGR02687 585396014843 PglZ domain; Region: PglZ; pfam08665 585396014844 Methyltransferase domain; Region: Methyltransf_26; pfam13659 585396014845 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 585396014846 Methyltransferase domain; Region: Methyltransf_26; pfam13659 585396014847 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 585396014848 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 585396014849 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 585396014850 Protein of unknown function DUF91; Region: DUF91; cl00709 585396014851 Integrative element ECO111_IE07; conserved predicted protein, C-terminal part 585396014852 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 585396014853 HNH endonuclease; Region: HNH_2; pfam13391 585396014854 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585396014855 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 585396014856 Kelch motif; Region: Kelch_1; pfam01344 585396014857 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 585396014858 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 585396014859 Int/Topo IB signature motif; other site 585396014860 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 585396014861 Int/Topo IB signature motif; other site 585396014862 Fimbrial protein; Region: Fimbrial; cl01416 585396014863 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585396014864 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 585396014865 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585396014866 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585396014867 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585396014868 PapC N-terminal domain; Region: PapC_N; pfam13954 585396014869 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585396014870 PapC C-terminal domain; Region: PapC_C; pfam13953 585396014871 putative transposase OrfB; Reviewed; Region: PHA02517 585396014872 HTH-like domain; Region: HTH_21; pfam13276 585396014873 Integrase core domain; Region: rve; pfam00665 585396014874 Integrase core domain; Region: rve_3; pfam13683 585396014875 Transposase; Region: HTH_Tnp_1; cl17663 585396014876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396014877 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585396014878 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585396014879 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 585396014880 mannosyl binding site [chemical binding]; other site 585396014881 Fimbrial protein; Region: Fimbrial; pfam00419 585396014882 fructuronate transporter; Provisional; Region: PRK10034 585396014883 gluconate transporter; Region: gntP; TIGR00791 585396014884 mannonate dehydratase; Region: uxuA; TIGR00695 585396014885 mannonate dehydratase; Provisional; Region: PRK03906 585396014886 D-mannonate oxidoreductase; Provisional; Region: PRK15037 585396014887 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585396014888 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585396014889 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 585396014890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396014891 DNA-binding site [nucleotide binding]; DNA binding site 585396014892 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585396014893 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 585396014894 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 585396014895 cell density-dependent motility repressor; Provisional; Region: PRK10082 585396014896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585396014897 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 585396014898 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 585396014899 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 585396014900 dimer interface [polypeptide binding]; other site 585396014901 active site 585396014902 hypothetical protein; Provisional; Region: PRK10519 585396014903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 585396014904 Nucleoside recognition; Region: Gate; pfam07670 585396014905 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 585396014906 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 585396014907 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585396014908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396014909 putative substrate translocation pore; other site 585396014910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 585396014911 SdiA-regulated; Region: SdiA-regulated; cd09971 585396014912 putative active site [active] 585396014913 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 585396014914 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 585396014915 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 585396014916 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 585396014917 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 585396014918 Predicted membrane protein [Function unknown]; Region: COG2733 585396014919 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 585396014920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396014921 putative substrate translocation pore; other site 585396014922 putative transposase; Provisional; Region: PRK09857 585396014923 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585396014924 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585396014925 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396014926 DNA-binding site [nucleotide binding]; DNA binding site 585396014927 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585396014928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585396014929 homodimer interface [polypeptide binding]; other site 585396014930 catalytic residue [active] 585396014931 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 585396014932 Penicillin G acylase precursor, truncated 585396014933 Transposase; Region: HTH_Tnp_1; cl17663 585396014934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396014935 putative transposase OrfB; Reviewed; Region: PHA02517 585396014936 HTH-like domain; Region: HTH_21; pfam13276 585396014937 Integrase core domain; Region: rve; pfam00665 585396014938 Integrase core domain; Region: rve_3; pfam13683 585396014939 Penicillin G acylase precursor 585396014940 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 585396014941 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 585396014942 P-loop, Walker A motif; other site 585396014943 Base recognition motif; other site 585396014944 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 585396014945 Uncharacterized small protein [Function unknown]; Region: COG2879 585396014946 carbon starvation protein A; Provisional; Region: PRK15015 585396014947 Carbon starvation protein CstA; Region: CstA; pfam02554 585396014948 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 585396014949 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 585396014950 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 585396014951 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 585396014952 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 585396014953 Cupin domain; Region: Cupin_2; pfam07883 585396014954 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396014955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396014956 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 585396014957 putative substrate translocation pore; other site 585396014958 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 585396014959 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 585396014960 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 585396014961 putative substrate binding pocket [chemical binding]; other site 585396014962 trimer interface [polypeptide binding]; other site 585396014963 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 585396014964 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 585396014965 putative active site [active] 585396014966 putative metal binding site [ion binding]; other site 585396014967 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 585396014968 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 585396014969 NAD binding site [chemical binding]; other site 585396014970 catalytic residues [active] 585396014971 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 585396014972 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 585396014973 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 585396014974 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 585396014975 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585396014976 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 585396014977 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585396014978 dimer interface [polypeptide binding]; other site 585396014979 ligand binding site [chemical binding]; other site 585396014980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585396014981 dimerization interface [polypeptide binding]; other site 585396014982 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585396014983 dimer interface [polypeptide binding]; other site 585396014984 putative CheW interface [polypeptide binding]; other site 585396014985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396014986 D-galactonate transporter; Region: 2A0114; TIGR00893 585396014987 putative substrate translocation pore; other site 585396014988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585396014989 DNA-binding site [nucleotide binding]; DNA binding site 585396014990 Transcriptional regulators [Transcription]; Region: GntR; COG1802 585396014991 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 585396014992 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585396014993 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585396014994 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 585396014995 putative NAD(P) binding site [chemical binding]; other site 585396014996 catalytic Zn binding site [ion binding]; other site 585396014997 structural Zn binding site [ion binding]; other site 585396014998 phosphoglycerol transferase I; Provisional; Region: PRK03776 585396014999 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 585396015000 hypothetical protein; Provisional; Region: PRK11667 585396015001 DNA replication protein DnaC; Validated; Region: PRK07952 585396015002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396015003 Walker A motif; other site 585396015004 ATP binding site [chemical binding]; other site 585396015005 Walker B motif; other site 585396015006 primosomal protein DnaI; Provisional; Region: PRK02854 585396015007 hypothetical protein; Provisional; Region: PRK09917 585396015008 Uncharacterized conserved protein [Function unknown]; Region: COG2966 585396015009 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 585396015010 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585396015011 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396015012 DNA binding residues [nucleotide binding] 585396015013 dimerization interface [polypeptide binding]; other site 585396015014 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 585396015015 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585396015016 DNA binding residues [nucleotide binding] 585396015017 dimerization interface [polypeptide binding]; other site 585396015018 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 585396015019 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 585396015020 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 585396015021 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 585396015022 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 585396015023 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 585396015024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585396015025 S-adenosylmethionine binding site [chemical binding]; other site 585396015026 DNA polymerase III subunit psi; Validated; Region: PRK06856 585396015027 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 585396015028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585396015029 Coenzyme A binding pocket [chemical binding]; other site 585396015030 dUMP phosphatase; Provisional; Region: PRK09449 585396015031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396015032 motif II; other site 585396015033 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 585396015034 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 585396015035 G1 box; other site 585396015036 putative GEF interaction site [polypeptide binding]; other site 585396015037 GTP/Mg2+ binding site [chemical binding]; other site 585396015038 Switch I region; other site 585396015039 G2 box; other site 585396015040 G3 box; other site 585396015041 Switch II region; other site 585396015042 G4 box; other site 585396015043 G5 box; other site 585396015044 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 585396015045 periplasmic protein; Provisional; Region: PRK10568 585396015046 BON domain; Region: BON; pfam04972 585396015047 BON domain; Region: BON; pfam04972 585396015048 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 585396015049 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 585396015050 active site 585396015051 nucleophile elbow; other site 585396015052 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585396015053 active site 585396015054 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 585396015055 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585396015056 FeS/SAM binding site; other site 585396015057 hypothetical protein; Provisional; Region: PRK10977 585396015058 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 585396015059 intersubunit interface [polypeptide binding]; other site 585396015060 active site 585396015061 catalytic residue [active] 585396015062 thymidine phosphorylase DeoA, C-terminal fragment 585396015063 phosphopentomutase; Provisional; Region: PRK05362 585396015064 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 585396015065 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 585396015066 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 585396015067 conserved predicted protein, C-terminal part 585396015068 conserved predicted protein, N-terminal part 585396015069 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 585396015070 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 585396015071 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 585396015072 hypothetical protein; Provisional; Region: PRK11246 585396015073 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 585396015074 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585396015075 motif II; other site 585396015076 DNA repair protein RadA; Region: sms; TIGR00416 585396015077 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 585396015078 Walker A motif/ATP binding site; other site 585396015079 ATP binding site [chemical binding]; other site 585396015080 Walker B motif; other site 585396015081 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 585396015082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585396015083 non-specific DNA binding site [nucleotide binding]; other site 585396015084 salt bridge; other site 585396015085 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 585396015086 sequence-specific DNA binding site [nucleotide binding]; other site 585396015087 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 585396015088 active site 585396015089 (T/H)XGH motif; other site 585396015090 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 585396015091 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 585396015092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585396015093 Walker A/P-loop; other site 585396015094 ATP binding site [chemical binding]; other site 585396015095 Q-loop/lid; other site 585396015096 ABC transporter signature motif; other site 585396015097 Walker B; other site 585396015098 D-loop; other site 585396015099 H-loop/switch region; other site 585396015100 ABC transporter; Region: ABC_tran_2; pfam12848 585396015101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585396015102 lytic murein transglycosylase; Provisional; Region: PRK11619 585396015103 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585396015104 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585396015105 catalytic residue [active] 585396015106 Trp operon repressor; Provisional; Region: PRK01381 585396015107 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 585396015108 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585396015109 catalytic core [active] 585396015110 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 585396015111 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585396015112 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 585396015113 hypothetical protein; Provisional; Region: PRK10756 585396015114 CreA protein; Region: CreA; pfam05981 585396015115 DNA-binding response regulator CreB; Provisional; Region: PRK11083 585396015116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396015117 active site 585396015118 phosphorylation site [posttranslational modification] 585396015119 intermolecular recognition site; other site 585396015120 dimerization interface [polypeptide binding]; other site 585396015121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396015122 DNA binding site [nucleotide binding] 585396015123 sensory histidine kinase CreC; Provisional; Region: PRK11100 585396015124 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585396015125 dimerization interface [polypeptide binding]; other site 585396015126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585396015127 dimer interface [polypeptide binding]; other site 585396015128 phosphorylation site [posttranslational modification] 585396015129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585396015130 ATP binding site [chemical binding]; other site 585396015131 Mg2+ binding site [ion binding]; other site 585396015132 G-X-G motif; other site 585396015133 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 585396015134 two-component response regulator; Provisional; Region: PRK11173 585396015135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585396015136 active site 585396015137 phosphorylation site [posttranslational modification] 585396015138 intermolecular recognition site; other site 585396015139 dimerization interface [polypeptide binding]; other site 585396015140 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585396015141 DNA binding site [nucleotide binding] 585396015142 putative RNA methyltransferase; Provisional; Region: PRK10433 585396015143 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 585396015144 Initiator Replication protein; Region: Rep_3; cl17676 585396015145 TraL protein; Region: TraL; cl06278 585396015146 TraE protein; Region: TraE; cl05060 585396015147 TraK protein; Region: TraK; pfam06586 585396015148 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 585396015149 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 585396015150 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 585396015151 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 585396015152 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 585396015153 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 585396015154 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 585396015155 Magnesium ion binding site [ion binding]; other site 585396015156 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 585396015157 ParB-like nuclease domain; Region: ParB; smart00470 585396015158 ParB family; Region: ParB; pfam08775 585396015159 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 585396015160 active site 585396015161 metal binding site [ion binding]; metal-binding site 585396015162 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 585396015163 Mg binding site [ion binding]; other site 585396015164 nucleotide binding site [chemical binding]; other site 585396015165 putative protofilament interface [polypeptide binding]; other site 585396015166 conserved predicted protein, N-terminal part 585396015167 putative transposase OrfB; Reviewed; Region: PHA02517 585396015168 HTH-like domain; Region: HTH_21; pfam13276 585396015169 Integrase core domain; Region: rve; pfam00665 585396015170 Integrase core domain; Region: rve_3; pfam13683 585396015171 Transposase; Region: HTH_Tnp_1; cl17663 585396015172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396015173 conserved predicted protein, C-terminal part 585396015174 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 585396015175 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 585396015176 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 585396015177 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 585396015178 TraU protein; Region: TraU; pfam06834 585396015179 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14877 585396015180 conserved predicted protein, N-terminal part 585396015181 putative transposase OrfB; Reviewed; Region: PHA02517 585396015182 HTH-like domain; Region: HTH_21; pfam13276 585396015183 Integrase core domain; Region: rve; pfam00665 585396015184 Integrase core domain; Region: rve_3; pfam13683 585396015185 Transposase; Region: HTH_Tnp_1; cl17663 585396015186 conserved predicted protein, C-terminal part 585396015187 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 585396015188 Part of AAA domain; Region: AAA_19; pfam13245 585396015189 Family description; Region: UvrD_C_2; pfam13538 585396015190 Transposase; Region: HTH_Tnp_1; cl17663 585396015191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396015192 putative transposase OrfB; Reviewed; Region: PHA02517 585396015193 HTH-like domain; Region: HTH_21; pfam13276 585396015194 Integrase core domain; Region: rve; pfam00665 585396015195 Integrase core domain; Region: rve_3; pfam13683 585396015196 putative lipoprotein, N-terminal part 585396015197 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 585396015198 Part of AAA domain; Region: AAA_19; pfam13245 585396015199 Family description; Region: UvrD_C_2; pfam13538 585396015200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585396015201 Walker A motif; other site 585396015202 ATP binding site [chemical binding]; other site 585396015203 Walker B motif; other site 585396015204 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 585396015205 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 585396015206 metal ion-dependent adhesion site (MIDAS); other site 585396015207 Toprim domain; Region: Toprim_3; pfam13362 585396015208 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 585396015209 DNA replication terminus site-binding protein (Ter protein); Region: Ter; pfam05472 585396015210 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 585396015211 DNA binding site [nucleotide binding] 585396015212 dimer interface [polypeptide binding]; other site 585396015213 active site 585396015214 Int/Topo IB signature motif; other site 585396015215 Haemolysin expression modulating protein; Region: HHA; pfam05321 585396015216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585396015217 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585396015218 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585396015219 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585396015220 replication protein; Provisional; Region: PRK13742 585396015221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585396015222 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585396015223 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585396015224 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 585396015225 HNH endonuclease; Region: HNH_2; pfam13391 585396015226 HNH endonuclease; Region: HNH_2; pfam13391 585396015227 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 585396015228 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585396015229 Methyltransferase domain; Region: Methyltransf_27; pfam13708 585396015230 Methyltransferase domain; Region: Methyltransf_27; pfam13708 585396015231 Predicted ATPase [General function prediction only]; Region: COG3910 585396015232 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 585396015233 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 585396015234 DNA cytosine methylase; Provisional; Region: PRK10458 585396015235 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 585396015236 cofactor binding site; other site 585396015237 DNA binding site [nucleotide binding] 585396015238 substrate interaction site [chemical binding]; other site 585396015239 Staphylococcal nuclease homologues; Region: SNc; smart00318 585396015240 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 585396015241 Catalytic site; other site 585396015242 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 585396015243 PLD-like domain; Region: PLDc_2; pfam13091 585396015244 putative homodimer interface [polypeptide binding]; other site 585396015245 putative active site [active] 585396015246 catalytic site [active] 585396015247 conserved predicted protein, C-terminal part 585396015248 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585396015249 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 585396015250 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 585396015251 homoserine dehydrogenase; Provisional; Region: PRK06349 585396015252 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585396015253 dimerization interface [polypeptide binding]; other site 585396015254 putative DNA binding site [nucleotide binding]; other site 585396015255 putative Zn2+ binding site [ion binding]; other site 585396015256 tetracycline repressor protein TetR; Provisional; Region: PRK13756 585396015257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585396015258 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 585396015259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585396015260 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585396015261 putative substrate translocation pore; other site 585396015262 predicted transcriptional regulator TetC, C-terminal part 585396015263 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585396015264 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585396015265 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585396015266 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585396015267 putative transcriptional regulator MerR; Provisional; Region: PRK13752 585396015268 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 585396015269 DNA binding residues [nucleotide binding] 585396015270 dimer interface [polypeptide binding]; other site 585396015271 mercury binding site [ion binding]; other site 585396015272 putative mercuric transport protein; Provisional; Region: PRK13751 585396015273 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585396015274 metal-binding site [ion binding] 585396015275 putative mercury transport protein MerC; Provisional; Region: PRK13755 585396015276 putative mercuric reductase; Provisional; Region: PRK13748 585396015277 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585396015278 metal-binding site [ion binding] 585396015279 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585396015280 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585396015281 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585396015282 transcriptional regulator MerD; Provisional; Region: PRK13749 585396015283 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 585396015284 DNA binding residues [nucleotide binding] 585396015285 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585396015286 Integrase core domain; Region: rve; pfam00665 585396015287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 585396015288 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585396015289 Integrase core domain; Region: rve; pfam00665 585396015290 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 585396015291 Phosphotransferase enzyme family; Region: APH; pfam01636 585396015292 active site 585396015293 ATP binding site [chemical binding]; other site 585396015294 antibiotic binding site [chemical binding]; other site 585396015295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 585396015296 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585396015297 Integrase core domain; Region: rve; pfam00665 585396015298 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 585396015299 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 585396015300 Phosphotransferase enzyme family; Region: APH; pfam01636 585396015301 active site 585396015302 ATP binding site [chemical binding]; other site 585396015303 antibiotic binding site [chemical binding]; other site 585396015304 dihydropteroate synthase; Region: DHPS; TIGR01496 585396015305 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 585396015306 substrate binding pocket [chemical binding]; other site 585396015307 dimer interface [polypeptide binding]; other site 585396015308 inhibitor binding site; inhibition site 585396015309 Replication protein C (RepC); Region: RepC; pfam06504 585396015310 predicted replication protein A, C-terminal part 585396015311 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 585396015312 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585396015313 Integrase core domain; Region: rve; pfam00665 585396015314 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 585396015315 beta-lactamase TEM; Provisional; Region: PRK15442 585396015316 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 585396015317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 585396015318 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585396015319 Integrase core domain; Region: rve; pfam00665 585396015320 predicted transposase TnpA of Transposon Tn21, C-terminal part , N-terminal truncated by IS26 insertion 585396015321 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 585396015322 chloramphenicol acetyltransferase; Provisional; Region: PRK13757 585396015323 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 585396015324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585396015325 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585396015326 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585396015327 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585396015328 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 585396015329 Homeodomain-like domain; Region: HTH_23; pfam13384 585396015330 Winged helix-turn helix; Region: HTH_29; pfam13551 585396015331 Homeodomain-like domain; Region: HTH_32; pfam13565 585396015332 Integrase core domain; Region: rve; pfam00665 585396015333 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 585396015334 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585396015335 Catalytic site [active] 585396015336 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 585396015337 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 585396015338 active site 585396015339 DNA binding site [nucleotide binding] 585396015340 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 585396015341 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 585396015342 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 585396015343 catalytic residues [active] 585396015344 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 585396015345 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 585396015346 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 585396015347 dimerization domain [polypeptide binding]; other site 585396015348 dimer interface [polypeptide binding]; other site 585396015349 catalytic residues [active] 585396015350 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585396015351 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585396015352 Transposase; Region: HTH_Tnp_1; cl17663 585396015353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396015354 putative transposase OrfB; Reviewed; Region: PHA02517 585396015355 HTH-like domain; Region: HTH_21; pfam13276 585396015356 Integrase core domain; Region: rve; pfam00665 585396015357 Integrase core domain; Region: rve_3; pfam13683 585396015358 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 585396015359 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 585396015360 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 585396015361 TraF-like protein; Region: TraF-like; TIGR02740 585396015362 F plasmid transfer operon protein; Region: TraF; pfam13728 585396015363 Putative helicase; Region: TraI_2; pfam07514 585396015364 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 585396015365 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 585396015366 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 585396015367 Domain of unknown function (DUF4400); Region: DUF4400; pfam14348 585396015368 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 585396015369 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 585396015370 tandem repeat interface [polypeptide binding]; other site 585396015371 oligomer interface [polypeptide binding]; other site 585396015372 active site residues [active] 585396015373 Nuclease-related domain; Region: NERD; pfam08378 585396015374 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 585396015375 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 585396015376 envelope glycoprotein I; Provisional; Region: PHA03291 585396015377 predicted protein, C-terminal part 585396015378 small toxic polypeptide; Provisional; Region: PRK09738 585396015379 conserved predicted protein, C-terminal part 585396015380 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 585396015381 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 585396015382 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585396015383 active site 585396015384 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 585396015385 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585396015386 Active Sites [active] 585396015387 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 585396015388 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 585396015389 Domain of unknown function (DUF4165); Region: DUF4165; pfam13752 585396015390 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 585396015391 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 585396015392 Domain of unknown function (DUF4165); Region: DUF4165; pfam13752 585396015393 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 585396015394 Initiator Replication protein; Region: Rep_3; cl03080 585396015395 Domain of unknown function (DUF4165); Region: DUF4165; pfam13752 585396015396 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 585396015397 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585396015398 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 585396015399 Methyltransferase domain; Region: Methyltransf_27; pfam13708 585396015400 Methyltransferase domain; Region: Methyltransf_26; pfam13659 585396015401 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 585396015402 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585396015403 RTX toxin acyltransferase family; Region: HlyC; pfam02794 585396015404 RTX N-terminal domain; Region: RTX; pfam02382 585396015405 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 585396015406 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 585396015407 RTX C-terminal domain; Region: RTX_C; pfam08339 585396015408 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 585396015409 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 585396015410 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585396015411 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 585396015412 Walker A/P-loop; other site 585396015413 ATP binding site [chemical binding]; other site 585396015414 Q-loop/lid; other site 585396015415 ABC transporter signature motif; other site 585396015416 Walker B; other site 585396015417 D-loop; other site 585396015418 H-loop/switch region; other site 585396015419 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 585396015420 HlyD family secretion protein; Region: HlyD_3; pfam13437 585396015421 Integrase core domain; Region: rve; pfam00665 585396015422 Integrase core domain; Region: rve_3; pfam13683 585396015423 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 585396015424 homodimer interface [polypeptide binding]; other site 585396015425 putative GKAP docking site [polypeptide binding]; other site 585396015426 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585396015427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585396015428 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585396015429 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585396015430 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585396015431 predicted protein Orf2 insertion sequence ISEc8, N-terminal truncated 585396015432 Transposase; Region: HTH_Tnp_1; pfam01527 585396015433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396015434 predicted protein Orf3 in insertion sequence ISEc8, C-terminal fragment 585396015435 Staphylococcal nuclease homologues; Region: SNc; smart00318 585396015436 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 585396015437 Catalytic site; other site 585396015438 Haemolysin expression modulating protein; Region: HHA; cl11501 585396015439 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 585396015440 replication protein; Provisional; Region: PRK13702 585396015441 replication protein; Provisional; Region: PRK13750 585396015442 replication protein A4 RepA4, N-terminal part 585396015443 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 585396015444 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 585396015445 Putative transposase; Region: Y2_Tnp; pfam04986 585396015446 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 585396015447 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 585396015448 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585396015449 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585396015450 putative transposase OrfB; Reviewed; Region: PHA02517 585396015451 HTH-like domain; Region: HTH_21; pfam13276 585396015452 Integrase core domain; Region: rve; pfam00665 585396015453 Integrase core domain; Region: rve_3; pfam13683 585396015454 Transposase; Region: HTH_Tnp_1; cl17663 585396015455 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396015456 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 585396015457 conserved predicted plasmid protein, truncated by IS insertion 585396015458 Transposase; Region: HTH_Tnp_1; cl17663 585396015459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396015460 putative transposase OrfB; Reviewed; Region: PHA02517 585396015461 HTH-like domain; Region: HTH_21; pfam13276 585396015462 Integrase core domain; Region: rve; pfam00665 585396015463 Integrase core domain; Region: rve_3; pfam13683 585396015464 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 585396015465 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 585396015466 PRTRC system protein D; Region: PRTRC_D; TIGR03739 585396015467 Mg binding site [ion binding]; other site 585396015468 nucleotide binding site [chemical binding]; other site 585396015469 putative protofilament interface [polypeptide binding]; other site 585396015470 conserved predicted plasmid protein, N-terminal part of ECsL40 585396015471 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 585396015472 Putative transposase; Region: Y2_Tnp; pfam04986 585396015473 Antirestriction protein; Region: Antirestrict; pfam03230 585396015474 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 585396015475 conserved predicted plasmid protein ECsL53, N-terminal part 585396015476 conserved predicted plasmid protein, C-terminal part of ECsL51 585396015477 conserved predicted plasmid protein, N-terminal part of ECsL52 585396015478 conserved predicted protein, N-terminal part 585396015479 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 585396015480 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585396015481 dimer interface [polypeptide binding]; other site 585396015482 ssDNA binding site [nucleotide binding]; other site 585396015483 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585396015484 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 585396015485 ParB-like nuclease domain; Region: ParBc; pfam02195 585396015486 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 585396015487 KorB domain; Region: KorB; pfam08535 585396015488 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 585396015489 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 585396015490 small toxic polypeptide; Provisional; Region: PRK09738 585396015491 conserved predicted protein, N-terminal part 585396015492 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585396015493 conserved predicted plasmid protein, C-terminal part 585396015494 predicted transglycosylase, N-terminal part 585396015495 TraM protein; Region: Tra_M; pfam05261 585396015496 conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719 585396015497 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 585396015498 conjugal transfer protein TraY; Provisional; Region: PRK13740 585396015499 TraY domain; Region: TraY; cl17675 585396015500 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 585396015501 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 585396015502 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 585396015503 conjugal transfer protein TraK; Provisional; Region: PRK13736 585396015504 TraK protein; Region: TraK; pfam06586 585396015505 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 585396015506 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 585396015507 conjugal transfer protein TraP; Provisional; Region: PRK13739 585396015508 conjugal transfer protein TraH, C-part 585396015509 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 585396015510 putative transposase OrfB; Reviewed; Region: PHA02517 585396015511 HTH-like domain; Region: HTH_21; pfam13276 585396015512 Integrase core domain; Region: rve; pfam00665 585396015513 Integrase core domain; Region: rve_3; pfam13683 585396015514 Transposase; Region: HTH_Tnp_1; cl17663 585396015515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396015516 conjugal transfer: inner membrane and periplasmic mating pair stabilization protein TraG, C-part 585396015517 conjugal transfer entry exclusion protein TraS; Provisional; Region: PRK13741 585396015518 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 585396015519 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 585396015520 conjugal transfer protein TraD; Provisional; Region: PRK13700 585396015521 F sex factor protein N terminal; Region: TraD_N; pfam12615 585396015522 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 585396015523 multimer interface [polypeptide binding]; other site 585396015524 Walker A motif; other site 585396015525 ATP binding site [chemical binding]; other site 585396015526 Walker B motif; other site 585396015527 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 585396015528 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 585396015529 AAA domain; Region: AAA_30; pfam13604 585396015530 DNA helicase TraI; Region: TraI; pfam07057 585396015531 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 585396015532 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 585396015533 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 585396015534 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 585396015535 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 585396015536 putative RNA binding sites [nucleotide binding]; other site 585396015537 Transposase; Region: HTH_Tnp_1; pfam01527 585396015538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396015539 predicted protein Orf2 in insertion sequence ISEc8, N-terminal truncated 585396015540 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 585396015541 homodimer interface [polypeptide binding]; other site 585396015542 putative GKAP docking site [polypeptide binding]; other site 585396015543 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585396015544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585396015545 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585396015546 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585396015547 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585396015548 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585396015549 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585396015550 putative acyl-acceptor binding pocket; other site 585396015551 hypothetical protein; Provisional; Region: PRK10649 585396015552 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585396015553 Sulfatase; Region: Sulfatase; pfam00884 585396015554 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585396015555 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585396015556 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 585396015557 putative active site [active] 585396015558 putative metal binding site [ion binding]; other site 585396015559 putative invertase 585396015560 putative transposase OrfA protein of insertion sequence IS629, N-terminal fragment 585396015561 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 585396015562 Putative transposase; Region: Y2_Tnp; pfam04986 585396015563 predicted transposase OrfB protein of insertion sequence IS629, C-terminal truncated 585396015564 Replicase family; Region: Replicase; pfam03090 585396015565 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 585396015566 MobA/MobL family; Region: MobA_MobL; pfam03389 585396015567 Colicin-like bacteriocin tRNase domain; Region: Cloacin; pfam03515 585396015568 Coiled-coil receptor-binding R-domain of colicin E2; Region: E2R135; pfam11570 585396015569 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585396015570 active site 585396015571 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 585396015572 Lysis protein; Region: Lysis_col; pfam02402 585396015573 Cloacin immunity protein; Region: Cloacin_immun; pfam03513 585396015574 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 585396015575 Rop protein; Region: Rop; pfam01815 585396015576 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 585396015577 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 585396015578 Colicin-like bacteriocin tRNase domain; Region: Cloacin; pfam03515 585396015579 S-type Pyocin; Region: Pyocin_S; pfam06958 585396015580 Colicin D; Region: Colicin_D; pfam11429 585396015581 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 585396015582 Lysis protein; Region: Lysis_col; pfam02402 585396015583 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 585396015584 DNA binding site [nucleotide binding] 585396015585 dimer interface [polypeptide binding]; other site 585396015586 active site 585396015587 Int/Topo IB signature motif; other site 585396015588 ORF6N domain; Region: ORF6N; pfam10543 585396015589 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 585396015590 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 585396015591 Methyltransferase domain; Region: Methyltransf_26; pfam13659 585396015592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585396015593 ATP-binding site [chemical binding]; other site 585396015594 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585396015595 catalytic residues [active] 585396015596 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 585396015597 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585396015598 dimer interface [polypeptide binding]; other site 585396015599 ssDNA binding site [nucleotide binding]; other site 585396015600 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585396015601 putative single-stranded DNA-binding protein; Region: PHA01740 585396015602 inosine-5'-monophosphate dehydrogenase; Provisional; Region: PTZ00314 585396015603 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 585396015604 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585396015605 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 585396015606 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585396015607 trimer interface [polypeptide binding]; other site 585396015608 active site 585396015609 substrate binding site [chemical binding]; other site 585396015610 CoA binding site [chemical binding]; other site 585396015611 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585396015612 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585396015613 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585396015614 Phage Tail Collar Domain; Region: Collar; pfam07484 585396015615 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 585396015616 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 585396015617 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585396015618 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585396015619 catalytic residue [active] 585396015620 ABC transporter C family member; Provisional; Region: PLN03130 585396015621 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 585396015622 KilA-N domain; Region: KilA-N; pfam04383 585396015623 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 585396015624 Hok/gef family; Region: HOK_GEF; pfam01848 585396015625 ParB-like nuclease domain; Region: ParBc; pfam02195 585396015626 ParB family; Region: ParB; pfam08775 585396015627 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 585396015628 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 585396015629 P-loop; other site 585396015630 Magnesium ion binding site [ion binding]; other site 585396015631 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 585396015632 Magnesium ion binding site [ion binding]; other site 585396015633 T5orf172 domain; Region: T5orf172; pfam10544 585396015634 PAAR motif; Region: PAAR_motif; cl15808 585396015635 Putative exonuclease, RdgC; Region: RdgC; pfam04381 585396015636 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 585396015637 cofactor binding site; other site 585396015638 Hint domain; Region: Hint_2; pfam13403 585396015639 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 585396015640 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 585396015641 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 585396015642 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 585396015643 DNA binding site [nucleotide binding] 585396015644 substrate interaction site [chemical binding]; other site 585396015645 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 585396015646 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 585396015647 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 585396015648 SPFH domain / Band 7 family; Region: Band_7; pfam01145 585396015649 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 585396015650 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 585396015651 replicative DNA helicase; Provisional; Region: PRK08006 585396015652 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 585396015653 Walker A motif; other site 585396015654 ATP binding site [chemical binding]; other site 585396015655 Walker B motif; other site 585396015656 DNA binding loops [nucleotide binding] 585396015657 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 585396015658 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 585396015659 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 585396015660 VRR-NUC domain; Region: VRR_NUC; pfam08774 585396015661 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 585396015662 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 585396015663 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585396015664 active site 585396015665 metal binding site [ion binding]; metal-binding site 585396015666 probable morphogenetic protein, N-terminal part 585396015667 Transposase; Region: HTH_Tnp_1; cl17663 585396015668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396015669 putative transposase OrfB; Reviewed; Region: PHA02517 585396015670 HTH-like domain; Region: HTH_21; pfam13276 585396015671 Integrase core domain; Region: rve; pfam00665 585396015672 Integrase core domain; Region: rve_3; pfam13683 585396015673 probable morphogenetic protein, C-terminal part 585396015674 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 585396015675 This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; Region: LNS2; smart00775 585396015676 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 585396015677 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 585396015678 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585396015679 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585396015680 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 585396015681 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 585396015682 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 585396015683 active site 585396015684 metal binding site [ion binding]; metal-binding site 585396015685 interdomain interaction site; other site 585396015686 conserved predicted protein, C-terminal part 585396015687 conserved predicted protein, N-terminal part 585396015688 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585396015689 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585396015690 Catalytic site [active] 585396015691 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 585396015692 death-on-curing family protein; Region: DOC_P1; TIGR01550 585396015693 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585396015694 Ash protein family; Region: Phage_ASH; pfam10554 585396015695 putative transposase OrfB; Reviewed; Region: PHA02517 585396015696 HTH-like domain; Region: HTH_21; pfam13276 585396015697 Integrase core domain; Region: rve; pfam00665 585396015698 Integrase core domain; Region: rve_3; pfam13683 585396015699 Transposase; Region: HTH_Tnp_1; cl17663 585396015700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585396015701 ORF6N domain; Region: ORF6N; pfam10543 585396015702 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374