-- dump date 20140619_085631 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_002327593.1 215485162 7062056 190..255 1 NC_011601.1 involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 255 thrL 7062056 thrL Escherichia coli O127:H6 str. E2348/69 thr operon leader peptide YP_002327593.1 190 D 574521 CDS YP_002327594.1 215485163 7061796 336..2798 1 NC_011601.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 2798 thrA 7061796 thrA Escherichia coli O127:H6 str. E2348/69 bifunctional aspartokinase I/homoserine dehydrogenase I YP_002327594.1 336 D 574521 CDS YP_002327595.1 215485164 7061793 2800..3732 1 NC_011601.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3732 thrB 7061793 thrB Escherichia coli O127:H6 str. E2348/69 homoserine kinase YP_002327595.1 2800 D 574521 CDS YP_002327596.1 215485165 7061794 3733..5019 1 NC_011601.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 5019 thrC 7061794 thrC Escherichia coli O127:H6 str. E2348/69 threonine synthase YP_002327596.1 3733 D 574521 CDS YP_002327597.1 215485166 7061795 5233..5529 1 NC_011601.1 hypothetical protein 5529 yaaX 7061795 yaaX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327597.1 5233 D 574521 CDS YP_002327598.1 215485167 7064881 complement(5579..6355) 1 NC_011601.1 hypothetical protein 6355 yaaA 7064881 yaaA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327598.1 5579 R 574521 CDS YP_002327599.1 215485168 7064875 complement(6425..7855) 1 NC_011601.1 transporter 7855 yaaJ 7064875 yaaJ Escherichia coli O127:H6 str. E2348/69 transporter YP_002327599.1 6425 R 574521 CDS YP_002327600.1 215485169 7064878 8134..9087 1 NC_011601.1 transaldolase B 9087 talB 7064878 talB Escherichia coli O127:H6 str. E2348/69 transaldolase B YP_002327600.1 8134 D 574521 CDS YP_002327601.1 215485170 7061750 9202..9789 1 NC_011601.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9789 mogA 7061750 mogA Escherichia coli O127:H6 str. E2348/69 molybdenum cofactor biosynthesis protein MogA YP_002327601.1 9202 D 574521 CDS YP_002327602.1 215485171 7064960 9973..11346 1 NC_011601.1 transposase of ISEc13 11346 7064960 E2348C_0010 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002327602.1 9973 D 574521 CDS YP_002327603.1 215485172 7062057 complement(11382..11948) 1 NC_011601.1 hypothetical protein 11948 yaaH 7062057 yaaH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327603.1 11382 R 574521 CDS YP_002327604.1 215485173 7064876 complement(12097..12810) 1 NC_011601.1 hypothetical protein 12810 yaaW 7064876 yaaW Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327604.1 12097 R 574521 CDS YP_002327605.1 215485174 7064880 complement(12836..13240) 1 NC_011601.1 hypothetical protein 13240 yaaI 7064880 yaaI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327605.1 12836 R 574521 CDS YP_002327606.1 215485175 7064877 13612..15528 1 NC_011601.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 15528 dnaK 7064877 dnaK Escherichia coli O127:H6 str. E2348/69 molecular chaperone DnaK YP_002327606.1 13612 D 574521 CDS YP_002327607.1 215485176 7065050 15617..16747 1 NC_011601.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 16747 dnaJ 7065050 dnaJ Escherichia coli O127:H6 str. E2348/69 molecular chaperone DnaJ YP_002327607.1 15617 D 574521 CDS YP_002327608.1 215485177 7065049 complement(16852..17061) 1 NC_011601.1 regulatory protein MokC for HokC 1 17061 mokC1 7065049 mokC1 Escherichia coli O127:H6 str. E2348/69 regulatory protein MokC for HokC 1 YP_002327608.1 16852 R 574521 CDS YP_002327609.1 215485178 7063819 complement(16852..17004) 1 NC_011601.1 small toxic membrane peptide HokC 1 17004 hokC1 7063819 hokC1 Escherichia coli O127:H6 str. E2348/69 small toxic membrane peptide HokC 1 YP_002327609.1 16852 R 574521 CDS YP_002327610.1 215485179 7062736 17619..18380 1 NC_011601.1 hypothetical protein 18380 7062736 E2348C_0018 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327610.1 17619 D 574521 CDS YP_002327611.1 215485180 7063424 18401..19894 1 NC_011601.1 arylsulfatase 19894 7063424 E2348C_0019 Escherichia coli O127:H6 str. E2348/69 arylsulfatase YP_002327611.1 18401 D 574521 CDS YP_002327612.1 215485181 7063425 20023..21282 1 NC_011601.1 hypothetical protein 21282 7063425 E2348C_0020 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327612.1 20023 D 574521 CDS YP_002327613.1 215485182 7063426 21517..22683 1 NC_011601.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 22683 nhaA 7063426 nhaA Escherichia coli O127:H6 str. E2348/69 pH-dependent sodium/proton antiporter YP_002327613.1 21517 D 574521 CDS YP_002327614.1 215485183 7065387 22743..23648 1 NC_011601.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 23648 nhaR 7065387 nhaR Escherichia coli O127:H6 str. E2348/69 transcriptional activator NhaR YP_002327614.1 22743 D 574521 CDS YP_002327615.1 215485184 7065389 complement(23744..24007) 1 NC_011601.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 24007 rpsT 7065389 rpsT Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S20 YP_002327615.1 23744 R 574521 CDS YP_002327616.1 215485185 7061892 24110..24328 1 NC_011601.1 hypothetical protein 24328 yaaY 7061892 yaaY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327616.1 24110 D 574521 CDS YP_002327617.1 215485186 7064882 24336..25277 1 NC_011601.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 25277 ribF 7064882 ribF Escherichia coli O127:H6 str. E2348/69 bifunctional riboflavin kinase/FMN adenylyltransferase YP_002327617.1 24336 D 574521 CDS YP_002327618.1 215485187 7060823 25320..28136 1 NC_011601.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 28136 ileS 7060823 ileS Escherichia coli O127:H6 str. E2348/69 isoleucyl-tRNA synthetase YP_002327618.1 25320 D 574521 CDS YP_002327619.1 215485188 7063523 28136..28630 1 NC_011601.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 28630 lspA 7063523 lspA Escherichia coli O127:H6 str. E2348/69 lipoprotein signal peptidase YP_002327619.1 28136 D 574521 CDS YP_002327620.1 215485189 7065247 28738..29187 1 NC_011601.1 FKBP-type peptidylprolyl isomerase 29187 fkpB 7065247 fkpB Escherichia coli O127:H6 str. E2348/69 FKBP-type peptidylprolyl isomerase YP_002327620.1 28738 D 574521 CDS YP_002327621.1 215485190 7062135 29189..30139 1 NC_011601.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 30139 ispH 7062135 ispH Escherichia coli O127:H6 str. E2348/69 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_002327621.1 29189 D 574521 CDS YP_002327622.1 215485191 7063557 30205..31119 1 NC_011601.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 31119 rihC 7063557 rihC Escherichia coli O127:H6 str. E2348/69 ribonucleoside hydrolase RihC YP_002327622.1 30205 D 574521 CDS YP_002327623.1 215485192 7060826 31286..32107 1 NC_011601.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 32107 dapB 7060826 dapB Escherichia coli O127:H6 str. E2348/69 dihydrodipicolinate reductase YP_002327623.1 31286 D 574521 CDS YP_002327624.1 215485193 7065221 32563..33711 1 NC_011601.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 33711 carA 7065221 carA Escherichia coli O127:H6 str. E2348/69 carbamoyl phosphate synthase small subunit YP_002327624.1 32563 D 574521 CDS YP_002327625.1 215485194 7064324 33729..36950 1 NC_011601.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 36950 carB 7064324 carB Escherichia coli O127:H6 str. E2348/69 carbamoyl phosphate synthase large subunit YP_002327625.1 33729 D 574521 CDS YP_002327626.1 215485195 7064325 complement(36958..37176) 1 NC_011601.1 hypothetical protein 37176 7064325 E2348C_0034 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327626.1 36958 R 574521 CDS YP_002327627.1 215485196 7063427 37211..37606 1 NC_011601.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 37606 caiF 7063427 caiF Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator CaiF YP_002327627.1 37211 D 574521 CDS YP_002327628.1 215485197 7064321 complement(37725..38315) 1 NC_011601.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE 38315 caiE 7064321 caiE Escherichia coli O127:H6 str. E2348/69 carnitine operon protein CaiE YP_002327628.1 37725 R 574521 CDS YP_002327629.2 229620020 7064320 complement(38321..39106) 1 NC_011601.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase 39106 caiD 7064320 caiD Escherichia coli O127:H6 str. E2348/69 carnitinyl-CoA dehydratase YP_002327629.2 38321 R 574521 CDS YP_002327630.1 215485199 7064319 complement(39215..40768) 1 NC_011601.1 crotonobetaine/carnitine-CoA ligase 40768 caiC 7064319 caiC Escherichia coli O127:H6 str. E2348/69 crotonobetaine/carnitine-CoA ligase YP_002327630.1 39215 R 574521 CDS YP_002327631.1 215485200 7064318 complement(40841..42058) 1 NC_011601.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase 42058 caiB 7064318 caiB Escherichia coli O127:H6 str. E2348/69 crotonobetainyl-CoA:carnitine CoA-transferase YP_002327631.1 40841 R 574521 CDS YP_002327632.1 215485201 7064317 complement(42176..43318) 1 NC_011601.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase 43318 caiA 7064317 caiA Escherichia coli O127:H6 str. E2348/69 crotonobetainyl-CoA dehydrogenase YP_002327632.1 42176 R 574521 CDS YP_002327633.1 215485202 7064316 complement(43349..44863) 1 NC_011601.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter 44863 caiT 7064316 caiT Escherichia coli O127:H6 str. E2348/69 L-carnitine/gamma-butyrobetaine antiporter YP_002327633.1 43349 R 574521 CDS YP_002327634.1 215485203 7064322 45277..46047 1 NC_011601.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; electron transfer flavoprotein FixA 46047 fixA 7064322 fixA Escherichia coli O127:H6 str. E2348/69 electron transfer flavoprotein FixA YP_002327634.1 45277 D 574521 CDS YP_002327635.1 215485204 7062130 46062..47003 1 NC_011601.1 involved in electron transfer during carnitine metabolism; electron transfer flavoprotein FixB 47003 fixB 7062130 fixB Escherichia coli O127:H6 str. E2348/69 electron transfer flavoprotein FixB YP_002327635.1 46062 D 574521 CDS YP_002327636.1 215485205 7062131 47054..48340 1 NC_011601.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; oxidoreductase FixC 48340 fixC 7062131 fixC Escherichia coli O127:H6 str. E2348/69 oxidoreductase FixC YP_002327636.1 47054 D 574521 CDS YP_002327637.1 215485206 7062132 48337..48624 1 NC_011601.1 4Fe-4S ferredoxin 48624 fixX 7062132 fixX Escherichia coli O127:H6 str. E2348/69 4Fe-4S ferredoxin YP_002327637.1 48337 D 574521 CDS YP_002327638.1 215485207 7062133 48683..50014 1 NC_011601.1 transporter 50014 yaaU 7062133 yaaU Escherichia coli O127:H6 str. E2348/69 transporter YP_002327638.1 48683 D 574521 CDS YP_002327639.1 215485208 7064879 50122..50652 1 NC_011601.1 Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 50652 kefF 7064879 kefF Escherichia coli O127:H6 str. E2348/69 glutathione-regulated potassium-efflux system ancillary protein KefF YP_002327639.1 50122 D 574521 CDS YP_002327640.1 215485209 7061502 50645..52507 1 NC_011601.1 transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 52507 kefC 7061502 kefC Escherichia coli O127:H6 str. E2348/69 glutathione-regulated potassium-efflux system protein KefC YP_002327640.1 50645 D 574521 CDS YP_002327641.1 215485210 7061501 52699..53178 1 NC_011601.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 53178 folA 7061501 folA Escherichia coli O127:H6 str. E2348/69 dihydrofolate reductase YP_002327641.1 52699 D 574521 CDS YP_002327642.1 215485211 7061938 53264..53497 1 NC_011601.1 CcdA-like protein 53497 7061938 E2348C_0050 Escherichia coli O127:H6 str. E2348/69 CcdA-like protein YP_002327642.1 53264 D 574521 CDS YP_002327643.1 215485212 7063428 53500..53814 1 NC_011601.1 CcdB-like protein 53814 7063428 E2348C_0051 Escherichia coli O127:H6 str. E2348/69 CcdB-like protein YP_002327643.1 53500 D 574521 CDS YP_002327644.1 215485213 7063429 complement(53811..54659) 1 NC_011601.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 54659 apaH 7063429 apaH Escherichia coli O127:H6 str. E2348/69 diadenosine tetraphosphatase YP_002327644.1 53811 R 574521 CDS YP_002327645.1 215485214 7061348 complement(54666..55043) 1 NC_011601.1 protein associated with Co2+ and Mg2+ efflux; ApaG protein 55043 apaG 7061348 apaG Escherichia coli O127:H6 str. E2348/69 ApaG protein YP_002327645.1 54666 R 574521 CDS YP_002327646.1 215485215 7061347 complement(55046..55867) 1 NC_011601.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 55867 ksgA 7061347 ksgA Escherichia coli O127:H6 str. E2348/69 dimethyladenosine transferase YP_002327646.1 55046 R 574521 CDS YP_002327647.1 215485216 7061506 complement(55864..56853) 1 NC_011601.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 56853 pdxA 7061506 pdxA Escherichia coli O127:H6 str. E2348/69 4-hydroxythreonine-4-phosphate dehydrogenase YP_002327647.1 55864 R 574521 CDS YP_002327648.1 215485217 7062939 complement(56853..58139) 1 NC_011601.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA 58139 surA 7062939 surA Escherichia coli O127:H6 str. E2348/69 peptidyl-prolyl cis-trans isomerase SurA YP_002327648.1 56853 R 574521 CDS YP_002327649.1 215485218 7061744 complement(58192..60546) 1 NC_011601.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 60546 imp 7061744 imp Escherichia coli O127:H6 str. E2348/69 organic solvent tolerance protein YP_002327649.1 58192 R 574521 CDS YP_002327650.1 215485219 7063540 60801..61616 1 NC_011601.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 61616 djlA 7063540 djlA Escherichia coli O127:H6 str. E2348/69 Dna-J like membrane chaperone protein YP_002327650.1 60801 D 574521 CDS YP_002327651.1 215485220 7065035 complement(61734..62393) 1 NC_011601.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A 62393 rluA 7065035 rluA Escherichia coli O127:H6 str. E2348/69 23S rRNA/tRNA pseudouridine synthase A YP_002327651.1 61734 R 574521 CDS YP_002327652.1 215485221 7060838 complement(62405..65311) 1 NC_011601.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 65311 hepA 7060838 hepA Escherichia coli O127:H6 str. E2348/69 ATP-dependent helicase HepA YP_002327652.1 62405 R 574521 CDS YP_002327653.1 215485222 7064303 complement(65476..67827) 1 NC_011601.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II 67827 polB 7064303 polB Escherichia coli O127:H6 str. E2348/69 DNA polymerase II YP_002327653.1 65476 R 574521 CDS YP_002327654.1 215485223 7060769 complement(67902..68597) 1 NC_011601.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 68597 araD 7060769 araD Escherichia coli O127:H6 str. E2348/69 L-ribulose-5-phosphate 4-epimerase YP_002327654.1 67902 R 574521 CDS YP_002327655.1 215485224 7061359 complement(68712..70214) 1 NC_011601.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase 70214 araA 7061359 araA Escherichia coli O127:H6 str. E2348/69 L-arabinose isomerase YP_002327655.1 68712 R 574521 CDS YP_002327656.1 215485225 7061356 complement(70225..71925) 1 NC_011601.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 71925 araB 7061356 araB Escherichia coli O127:H6 str. E2348/69 ribulokinase YP_002327656.1 70225 R 574521 CDS YP_002327657.1 215485226 7061357 72264..73109 1 NC_011601.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 73109 araC 7061357 araC Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator AraC YP_002327657.1 72264 D 574521 CDS YP_002327658.1 215485227 7061358 73334..74566 1 NC_011601.1 ribokinase 74566 7061358 E2348C_0066 Escherichia coli O127:H6 str. E2348/69 ribokinase YP_002327658.1 73334 D 574521 CDS YP_002327659.1 215485228 7063430 74592..75515 1 NC_011601.1 dihydrodipicolinate synthetase 75515 7063430 E2348C_0067 Escherichia coli O127:H6 str. E2348/69 dihydrodipicolinate synthetase YP_002327659.1 74592 D 574521 CDS YP_002327660.1 215485229 7063431 75570..76523 1 NC_011601.1 hypothetical protein 76523 7063431 E2348C_0068 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327660.1 75570 D 574521 CDS YP_002327661.1 215485230 7063432 76572..77009 1 NC_011601.1 hypothetical protein 77009 7063432 E2348C_0069 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327661.1 76572 D 574521 CDS YP_002327662.1 215485231 7063433 77019..78506 1 NC_011601.1 hypothetical protein 78506 7063433 E2348C_0070 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327662.1 77019 D 574521 CDS YP_002327663.1 215485232 7063434 78690..79454 1 NC_011601.1 hypothetical protein 79454 yabI 7063434 yabI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327663.1 78690 D 574521 CDS YP_002327664.1 215485233 7064883 complement(79568..80266) 1 NC_011601.1 with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit 80266 thiQ 7064883 thiQ Escherichia coli O127:H6 str. E2348/69 thiamine transporter ATP-binding subunit YP_002327664.1 79568 R 574521 CDS YP_002327665.1 215485234 7061791 complement(80250..81860) 1 NC_011601.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 81860 thiP 7061791 thiP Escherichia coli O127:H6 str. E2348/69 thiamine transporter membrane protein YP_002327665.1 80250 R 574521 CDS YP_002327666.1 215485235 7061790 complement(81836..82819) 1 NC_011601.1 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit 82819 tbpA 7061790 tbpA Escherichia coli O127:H6 str. E2348/69 thiamine transporter substrate binding subunit YP_002327666.1 81836 R 574521 CDS YP_002327667.1 215485236 7061143 complement(82983..84638) 1 NC_011601.1 activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR 84638 sgrR 7061143 sgrR Escherichia coli O127:H6 str. E2348/69 transcriptional regulator SgrR YP_002327667.1 82983 R 574521 CDS YP_002327668.1 215485237 7062715 complement(84966..85571) 1 NC_011601.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 85571 leuD 7062715 leuD Escherichia coli O127:H6 str. E2348/69 isopropylmalate isomerase small subunit YP_002327668.1 84966 R 574521 CDS YP_002327669.1 215485238 7061524 complement(85582..86982) 1 NC_011601.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 86982 leuC 7061524 leuC Escherichia coli O127:H6 str. E2348/69 isopropylmalate isomerase large subunit YP_002327669.1 85582 R 574521 CDS YP_002327670.1 215485239 7061523 complement(86985..88076) 1 NC_011601.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 88076 leuB 7061523 leuB Escherichia coli O127:H6 str. E2348/69 3-isopropylmalate dehydrogenase YP_002327670.1 86985 R 574521 CDS YP_002327671.1 215485240 7061522 complement(88076..89647) 1 NC_011601.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 89647 leuA 7061522 leuA Escherichia coli O127:H6 str. E2348/69 2-isopropylmalate synthase YP_002327671.1 88076 R 574521 CDS YP_002327672.1 215485241 7061521 complement(89740..89826) 1 NC_011601.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide 89826 leuL 7061521 leuL Escherichia coli O127:H6 str. E2348/69 leu operon leader peptide YP_002327672.1 89740 R 574521 CDS YP_002327673.1 215485242 7061526 90485..91429 1 NC_011601.1 activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 91429 leuO 7061526 leuO Escherichia coli O127:H6 str. E2348/69 leucine transcriptional activator YP_002327673.1 90485 D 574521 CDS YP_002327674.1 215485243 7061527 91747..93471 1 NC_011601.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 93471 ilvI 7061527 ilvI Escherichia coli O127:H6 str. E2348/69 acetolactate synthase 3 catalytic subunit YP_002327674.1 91747 D 574521 CDS YP_002327675.1 215485244 7063535 93474..93965 1 NC_011601.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 93965 ilvH 7063535 ilvH Escherichia coli O127:H6 str. E2348/69 acetolactate synthase 3 regulatory subunit YP_002327675.1 93474 D 574521 CDS YP_002327677.1 215485246 7063435 94145..95149 1 NC_011601.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 95149 fruR 7063435 fruR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator FruR YP_002327677.1 94145 D 574521 CDS YP_002327678.1 215485247 7061962 95751..96209 1 NC_011601.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 96209 mraZ 7061962 mraZ Escherichia coli O127:H6 str. E2348/69 cell division protein MraZ YP_002327678.1 95751 D 574521 CDS YP_002327679.1 215485248 7060862 96211..97152 1 NC_011601.1 S-adenosyl-methyltransferase MraW 97152 mraW 7060862 mraW Escherichia coli O127:H6 str. E2348/69 S-adenosyl-methyltransferase MraW YP_002327679.1 96211 D 574521 CDS YP_002327680.1 215485249 7060859 97149..97514 1 NC_011601.1 membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 97514 ftsL 7060859 ftsL Escherichia coli O127:H6 str. E2348/69 cell division protein FtsL YP_002327680.1 97149 D 574521 CDS YP_002327681.1 215485250 7061586 97530..99296 1 NC_011601.1 transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) 99296 ftsI 7061586 ftsI Escherichia coli O127:H6 str. E2348/69 transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) YP_002327681.1 97530 D 574521 CDS YP_002327682.1 215485251 7061584 99283..100770 1 NC_011601.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 100770 murE 7061584 murE Escherichia coli O127:H6 str. E2348/69 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_002327682.1 99283 D 574521 CDS YP_002327683.1 215485252 7060891 100767..102125 1 NC_011601.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 102125 murF 7060891 murF Escherichia coli O127:H6 str. E2348/69 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_002327683.1 100767 D 574521 CDS YP_002327684.1 215485253 7060892 102119..103201 1 NC_011601.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 103201 mraY 7060892 mraY Escherichia coli O127:H6 str. E2348/69 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_002327684.1 102119 D 574521 CDS YP_002327685.1 215485254 7060861 103204..104520 1 NC_011601.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 104520 murD 7060861 murD Escherichia coli O127:H6 str. E2348/69 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_002327685.1 103204 D 574521 CDS YP_002327686.1 215485255 7060890 104520..105764 1 NC_011601.1 integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 105764 ftsW 7060890 ftsW Escherichia coli O127:H6 str. E2348/69 cell division protein FtsW YP_002327686.1 104520 D 574521 CDS YP_002327687.1 215485256 7061589 105761..106828 1 NC_011601.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 106828 murG 7061589 murG Escherichia coli O127:H6 str. E2348/69 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_002327687.1 105761 D 574521 CDS YP_002327688.1 215485257 7060893 106882..108357 1 NC_011601.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 108357 murC 7060893 murC Escherichia coli O127:H6 str. E2348/69 UDP-N-acetylmuramate--L-alanine ligase YP_002327688.1 106882 D 574521 CDS YP_002327689.1 215485258 7060889 108350..109270 1 NC_011601.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 109270 ddl 7060889 ddl Escherichia coli O127:H6 str. E2348/69 D-alanine--D-alanine ligase YP_002327689.1 108350 D 574521 CDS YP_002327690.1 215485259 7065238 109272..110102 1 NC_011601.1 involved in septum formation; cell division protein FtsQ 110102 ftsQ 7065238 ftsQ Escherichia coli O127:H6 str. E2348/69 cell division protein FtsQ YP_002327690.1 109272 D 574521 CDS YP_002327691.1 215485260 7061588 110099..111361 1 NC_011601.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 111361 ftsA 7061588 ftsA Escherichia coli O127:H6 str. E2348/69 cell division protein FtsA YP_002327691.1 110099 D 574521 CDS YP_002327692.1 215485261 7061581 111422..112573 1 NC_011601.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 112573 ftsZ 7061581 ftsZ Escherichia coli O127:H6 str. E2348/69 cell division protein FtsZ YP_002327692.1 111422 D 574521 CDS YP_002327693.1 215485262 7061592 112674..113591 1 NC_011601.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 113591 lpxC 7061592 lpxC Escherichia coli O127:H6 str. E2348/69 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_002327693.1 112674 D 574521 CDS YP_002327694.1 215485263 7061574 113821..114333 1 NC_011601.1 secM translational pause allows for the initiation of secA translation; SecA regulator SecM 114333 secM 7061574 secM Escherichia coli O127:H6 str. E2348/69 SecA regulator SecM YP_002327694.1 113821 D 574521 CDS YP_002327695.1 215485264 7065358 114395..117100 1 NC_011601.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 117100 secA 7065358 secA Escherichia coli O127:H6 str. E2348/69 preprotein translocase subunit SecA YP_002327695.1 114395 D 574521 CDS YP_002327696.1 215485265 7065352 117160..117558 1 NC_011601.1 nucleoside triphosphate pyrophosphohydrolase 117558 mutT 7065352 mutT Escherichia coli O127:H6 str. E2348/69 nucleoside triphosphate pyrophosphohydrolase YP_002327696.1 117160 D 574521 CDS YP_002327697.1 215485266 7060901 complement(117646..117843) 1 NC_011601.1 zinc-binding protein 117843 yacG 7060901 yacG Escherichia coli O127:H6 str. E2348/69 zinc-binding protein YP_002327697.1 117646 R 574521 CDS YP_002327698.1 215485267 7064886 complement(117853..118596) 1 NC_011601.1 hypothetical protein 118596 yacF 7064886 yacF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327698.1 117853 R 574521 CDS YP_002327699.1 215485268 7064885 complement(118596..119216) 1 NC_011601.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 119216 coaE 7064885 coaE Escherichia coli O127:H6 str. E2348/69 dephospho-CoA kinase YP_002327699.1 118596 R 574521 CDS YP_002327700.1 215485269 7062823 119442..120485 1 NC_011601.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 120485 guaC 7062823 guaC Escherichia coli O127:H6 str. E2348/69 guanosine 5'-monophosphate oxidoreductase YP_002327700.1 119442 D 574521 CDS YP_002327701.1 215485270 7064272 complement(120520..121722) 1 NC_011601.1 type IV pilin biogenesis protein 121722 hofC 7064272 hofC Escherichia coli O127:H6 str. E2348/69 type IV pilin biogenesis protein YP_002327701.1 120520 R 574521 CDS YP_002327702.1 215485271 7062162 complement(121712..123097) 1 NC_011601.1 hypothetical protein 123097 hofB 7062162 hofB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327702.1 121712 R 574521 CDS YP_002327703.1 215485272 7062161 complement(123107..123547) 1 NC_011601.1 major pilin subunit 123547 ppdD 7062161 ppdD Escherichia coli O127:H6 str. E2348/69 major pilin subunit YP_002327703.1 123107 R 574521 CDS YP_002327704.1 215485273 7061267 complement(123751..124644) 1 NC_011601.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase 124644 nadC 7061267 nadC Escherichia coli O127:H6 str. E2348/69 quinolinate phosphoribosyltransferase YP_002327704.1 123751 R 574521 CDS YP_002327705.1 215485274 7060906 124732..125283 1 NC_011601.1 N-acetyl-anhydromuranmyl-L-alanine amidase 125283 ampD 7060906 ampD Escherichia coli O127:H6 str. E2348/69 N-acetyl-anhydromuranmyl-L-alanine amidase YP_002327705.1 124732 D 574521 CDS YP_002327706.1 215485275 7062457 125280..126134 1 NC_011601.1 involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 126134 ampE 7062457 ampE Escherichia coli O127:H6 str. E2348/69 regulatory protein AmpE YP_002327706.1 125280 D 574521 CDS YP_002327707.1 215485276 7062458 complement(126177..127550) 1 NC_011601.1 aromatic amino acid transporter 127550 aroP 7062458 aroP Escherichia coli O127:H6 str. E2348/69 aromatic amino acid transporter YP_002327707.1 126177 R 574521 CDS YP_002327708.1 215485277 7061400 128091..128855 1 NC_011601.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 128855 pdhR 7061400 pdhR Escherichia coli O127:H6 str. E2348/69 transcriptional regulator PdhR YP_002327708.1 128091 D 574521 CDS YP_002327709.1 215485278 7062918 129016..131679 1 NC_011601.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 131679 aceE 7062918 aceE Escherichia coli O127:H6 str. E2348/69 pyruvate dehydrogenase subunit E1 YP_002327709.1 129016 D 574521 CDS YP_002327710.1 215485279 7062386 131694..133586 1 NC_011601.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 133586 aceF 7062386 aceF Escherichia coli O127:H6 str. E2348/69 dihydrolipoamide acetyltransferase YP_002327710.1 131694 D 574521 CDS YP_002327711.1 215485280 7062387 133794..135218 1 NC_011601.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 135218 lpd 7062387 lpd Escherichia coli O127:H6 str. E2348/69 dihydrolipoamide dehydrogenase YP_002327711.1 133794 D 574521 CDS YP_002327712.1 215485281 7061561 complement(135289..137142) 1 NC_011601.1 hypothetical protein 137142 yacH 7061561 yacH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327712.1 135289 R 574521 CDS YP_002327713.1 215485282 7064887 137497..140094 1 NC_011601.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 140094 acnB 7064887 acnB Escherichia coli O127:H6 str. E2348/69 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase YP_002327713.1 137497 D 574521 CDS YP_002327714.1 215485283 7062391 140269..140631 1 NC_011601.1 hypothetical protein 140631 yacL 7062391 yacL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327714.1 140269 D 574521 CDS YP_002327715.1 215485284 7064888 complement(140669..141463) 1 NC_011601.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase 141463 speD 7064888 speD Escherichia coli O127:H6 str. E2348/69 S-adenosylmethionine decarboxylase YP_002327715.1 140669 R 574521 CDS YP_002327716.1 215485285 7062743 complement(141479..142345) 1 NC_011601.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 142345 speE 7062743 speE Escherichia coli O127:H6 str. E2348/69 spermidine synthase YP_002327716.1 141479 R 574521 CDS YP_002327717.1 215485286 7062744 complement(142451..142798) 1 NC_011601.1 hypothetical protein 142798 yacC 7062744 yacC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327717.1 142451 R 574521 CDS YP_002327718.1 215485287 7064884 142964..144514 1 NC_011601.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 144514 cueO 7064884 cueO Escherichia coli O127:H6 str. E2348/69 multicopper oxidase YP_002327718.1 142964 D 574521 CDS YP_002327719.1 215485288 7065167 complement(144561..146951) 1 NC_011601.1 glucose dehydrogenase 146951 gcd 7065167 gcd Escherichia coli O127:H6 str. E2348/69 glucose dehydrogenase YP_002327719.1 144561 R 574521 CDS YP_002327720.1 215485289 7061639 147157..147693 1 NC_011601.1 hypoxanthine phosphoribosyltransferase 147693 hpt 7061639 hpt Escherichia coli O127:H6 str. E2348/69 hypoxanthine phosphoribosyltransferase YP_002327720.1 147157 D 574521 CDS YP_002327721.1 215485290 7062177 complement(147734..148396) 1 NC_011601.1 catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase 148396 can 7062177 can Escherichia coli O127:H6 str. E2348/69 carbonic anhydrase YP_002327721.1 147734 R 574521 CDS YP_002327722.1 215485291 7064323 148505..149431 1 NC_011601.1 transporter subunit: ATP-binding component of ABC superfamily 149431 yadG 7064323 yadG Escherichia coli O127:H6 str. E2348/69 transporter subunit: ATP-binding component of ABC superfamily YP_002327722.1 148505 D 574521 CDS YP_002327723.1 215485292 7064893 149428..150198 1 NC_011601.1 transporter subunit: membrane component of ABC superfamily 150198 yadH 7064893 yadH Escherichia coli O127:H6 str. E2348/69 transporter subunit: membrane component of ABC superfamily YP_002327723.1 149428 D 574521 CDS YP_002327724.1 215485293 7064894 150303..150743 1 NC_011601.1 PTS Enzyme IIA 150743 yadI 7064894 yadI Escherichia coli O127:H6 str. E2348/69 PTS Enzyme IIA YP_002327724.1 150303 D 574521 CDS YP_002327725.1 215485294 7064895 150807..152036 1 NC_011601.1 polysaccharide deacetylase 152036 yadE 7064895 yadE Escherichia coli O127:H6 str. E2348/69 polysaccharide deacetylase YP_002327725.1 150807 D 574521 CDS YP_002327726.1 215485295 7064892 complement(152040..152420) 1 NC_011601.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 152420 panD 7064892 panD Escherichia coli O127:H6 str. E2348/69 aspartate alpha-decarboxylase YP_002327726.1 152040 R 574521 CDS YP_002327727.1 215485296 7062908 152694..153662 1 NC_011601.1 transposase 153662 yadD 7062908 yadD Escherichia coli O127:H6 str. E2348/69 transposase YP_002327727.1 152694 D 574521 CDS YP_002327728.1 215485297 7064891 complement(153744..154595) 1 NC_011601.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 154595 panC 7064891 panC Escherichia coli O127:H6 str. E2348/69 pantoate--beta-alanine ligase YP_002327728.1 153744 R 574521 CDS YP_002327729.1 215485298 7062907 complement(154607..155401) 1 NC_011601.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 155401 panB 7062907 panB Escherichia coli O127:H6 str. E2348/69 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_002327729.1 154607 R 574521 CDS YP_002327730.1 215485299 7064890 complement(156830..157426) 1 NC_011601.1 fimbrial protein 157426 yadK 7064890 yadK Escherichia coli O127:H6 str. E2348/69 fimbrial protein YP_002327730.1 156830 R 574521 CDS YP_002327731.1 215485300 7064898 complement(158655..161243) 1 NC_011601.1 similar to the fimbrial usher protein PapC; outer membrane usher protein 161243 htrE 7064898 htrE Escherichia coli O127:H6 str. E2348/69 outer membrane usher protein YP_002327731.1 158655 R 574521 CDS YP_002327732.1 215485301 7063833 complement(162128..162718) 1 NC_011601.1 fimbrial-like protein 162718 yadN 7063833 yadN Escherichia coli O127:H6 str. E2348/69 fimbrial-like protein YP_002327732.1 162128 R 574521 CDS YP_002327733.1 215485302 7064899 complement(163077..163556) 1 NC_011601.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 163556 folK 7064899 folK Escherichia coli O127:H6 str. E2348/69 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_002327733.1 163077 R 574521 CDS YP_002327734.1 215485303 7061943 complement(163553..164917) 1 NC_011601.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase 164917 pcnB 7061943 pcnB Escherichia coli O127:H6 str. E2348/69 poly(A) polymerase YP_002327734.1 163553 R 574521 CDS YP_002327735.1 215485304 7062917 complement(165010..165936) 1 NC_011601.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 165936 yadB 7062917 yadB Escherichia coli O127:H6 str. E2348/69 glutamyl-Q tRNA(Asp) synthetase YP_002327735.1 165010 R 574521 CDS YP_002327736.1 215485305 7064889 complement(165973..166428) 1 NC_011601.1 RNA polymerase-binding transcription factor 166428 dksA 7064889 dksA Escherichia coli O127:H6 str. E2348/69 RNA polymerase-binding transcription factor YP_002327736.1 165973 R 574521 CDS YP_002327737.1 215485306 7065038 complement(166606..167310) 1 NC_011601.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 167310 sfsA 7065038 sfsA Escherichia coli O127:H6 str. E2348/69 sugar fermentation stimulation protein A YP_002327737.1 166606 R 574521 CDS YP_002327738.1 215485307 7062709 complement(167325..167855) 1 NC_011601.1 2'-5' RNA ligase 167855 ligT 7062709 ligT Escherichia coli O127:H6 str. E2348/69 2'-5' RNA ligase YP_002327738.1 167325 R 574521 CDS YP_002327739.1 215485308 7061541 167929..170358 1 NC_011601.1 similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 170358 hrpB 7061541 hrpB Escherichia coli O127:H6 str. E2348/69 ATP-dependent RNA helicase HrpB YP_002327739.1 167929 D 574521 CDS YP_002327740.1 215485309 7062179 170452..172986 1 NC_011601.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 172986 mrcB 7062179 mrcB Escherichia coli O127:H6 str. E2348/69 penicillin-binding protein 1b YP_002327740.1 170452 D 574521 CDS YP_002327741.1 215485310 7060864 173313..173879 1 NC_011601.1 fimbrial protein 173879 7060864 E2348C_0153 Escherichia coli O127:H6 str. E2348/69 fimbrial protein YP_002327741.1 173313 D 574521 CDS YP_002327742.1 215485311 7063437 174685..177162 1 NC_011601.1 fimbrial outer membrane usher protein 177162 7063437 E2348C_0155 Escherichia coli O127:H6 str. E2348/69 fimbrial outer membrane usher protein YP_002327742.1 174685 D 574521 CDS YP_002327743.1 215485312 7063438 177184..178194 1 NC_011601.1 fimbrial protein 178194 7063438 E2348C_0156 Escherichia coli O127:H6 str. E2348/69 fimbrial protein YP_002327743.1 177184 D 574521 CDS YP_002327744.1 215485313 7063439 178415..180610 1 NC_011601.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 180610 fhuA 7063439 fhuA Escherichia coli O127:H6 str. E2348/69 ferrichrome outer membrane transporter YP_002327744.1 178415 D 574521 CDS YP_002327745.1 215485314 7062111 180661..181458 1 NC_011601.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 181458 fhuC 7062111 fhuC Escherichia coli O127:H6 str. E2348/69 iron-hydroxamate transporter ATP-binding subunit YP_002327745.1 180661 D 574521 CDS YP_002327746.1 215485315 7062113 181458..182348 1 NC_011601.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 182348 fhuD 7062113 fhuD Escherichia coli O127:H6 str. E2348/69 iron-hydroxamate transporter substrate-binding subunit YP_002327746.1 181458 D 574521 CDS YP_002327747.1 215485316 7062114 182345..184327 1 NC_011601.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 184327 fhuB 7062114 fhuB Escherichia coli O127:H6 str. E2348/69 iron-hydroxamate transporter permease subunit YP_002327747.1 182345 D 574521 CDS YP_002327748.1 215485317 7062112 complement(184362..185642) 1 NC_011601.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 185642 hemL 7062112 hemL Escherichia coli O127:H6 str. E2348/69 glutamate-1-semialdehyde aminotransferase YP_002327748.1 184362 R 574521 CDS YP_002327749.1 215485318 7064299 185867..187288 1 NC_011601.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 187288 clcA 7064299 clcA Escherichia coli O127:H6 str. E2348/69 chloride channel protein YP_002327749.1 185867 D 574521 CDS YP_002327750.1 215485319 7062806 187370..187714 1 NC_011601.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 187714 yadR 7062806 yadR Escherichia coli O127:H6 str. E2348/69 iron-sulfur cluster insertion protein ErpA YP_002327750.1 187370 D 574521 CDS YP_002327751.1 215485320 7064900 complement(187761..188384) 1 NC_011601.1 hypothetical protein 188384 yadS 7064900 yadS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327751.1 187761 R 574521 CDS YP_002327752.1 215485321 7064901 complement(188422..189222) 1 NC_011601.1 solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF 189222 btuF 7064901 btuF Escherichia coli O127:H6 str. E2348/69 vitamin B12-transporter protein BtuF YP_002327752.1 188422 R 574521 CDS YP_002327753.1 215485322 7064311 complement(189215..189913) 1 NC_011601.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 189913 pfs 7064311 pfs Escherichia coli O127:H6 str. E2348/69 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_002327753.1 189215 R 574521 CDS YP_002327754.1 215485323 7060712 189997..191514 1 NC_011601.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 191514 dgt 7060712 dgt Escherichia coli O127:H6 str. E2348/69 deoxyguanosinetriphosphate triphosphohydrolase YP_002327754.1 189997 D 574521 CDS YP_002327755.1 215485324 7065020 191644..193068 1 NC_011601.1 protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 193068 degP 7065020 degP Escherichia coli O127:H6 str. E2348/69 serine endoprotease YP_002327755.1 191644 D 574521 CDS YP_002327756.1 215485325 7065003 193223..194380 1 NC_011601.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 194380 cdaR 7065003 cdaR Escherichia coli O127:H6 str. E2348/69 carbohydrate diacid transcriptional activator CdaR YP_002327756.1 193223 D 574521 CDS YP_002327757.1 215485326 7064340 complement(194433..194819) 1 NC_011601.1 hypothetical protein 194819 yaeH 7064340 yaeH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327757.1 194433 R 574521 CDS YP_002327758.1 215485327 7064904 complement(195129..195953) 1 NC_011601.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 195953 dapD 7064904 dapD Escherichia coli O127:H6 str. E2348/69 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_002327758.1 195129 R 574521 CDS YP_002327759.1 215485328 7065222 complement(195984..198656) 1 NC_011601.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 198656 glnD 7065222 glnD Escherichia coli O127:H6 str. E2348/69 PII uridylyl-transferase YP_002327759.1 195984 R 574521 CDS YP_002327760.1 215485329 7061678 complement(198718..199512) 1 NC_011601.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 199512 map 7061678 map Escherichia coli O127:H6 str. E2348/69 methionine aminopeptidase YP_002327760.1 198718 R 574521 CDS YP_002327761.1 215485330 7061778 199880..200605 1 NC_011601.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 200605 rpsB 7061778 rpsB Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S2 YP_002327761.1 199880 D 574521 CDS YP_002327762.1 215485331 7061874 200863..201714 1 NC_011601.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 201714 tsf 7061874 tsf Escherichia coli O127:H6 str. E2348/69 elongation factor Ts YP_002327762.1 200863 D 574521 CDS YP_002327763.1 215485332 7062270 201861..202586 1 NC_011601.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 202586 pyrH 7062270 pyrH Escherichia coli O127:H6 str. E2348/69 uridylate kinase YP_002327763.1 201861 D 574521 CDS YP_002327764.1 215485333 7063935 202878..203435 1 NC_011601.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 203435 frr 7063935 frr Escherichia coli O127:H6 str. E2348/69 ribosome recycling factor YP_002327764.1 202878 D 574521 CDS YP_002327765.1 215485334 7061957 203527..204723 1 NC_011601.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 204723 dxr 7061957 dxr Escherichia coli O127:H6 str. E2348/69 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_002327765.1 203527 D 574521 CDS YP_002327766.1 215485335 7065075 204909..205670 1 NC_011601.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 205670 ispU 7065075 ispU Escherichia coli O127:H6 str. E2348/69 undecaprenyl pyrophosphate synthase YP_002327766.1 204909 D 574521 CDS YP_002327767.1 215485336 7063558 205713..206540 1 NC_011601.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 206540 cdsA 7063558 cdsA Escherichia coli O127:H6 str. E2348/69 CDP-diglyceride synthase YP_002327767.1 205713 D 574521 CDS YP_002327768.1 215485337 7064343 206552..207904 1 NC_011601.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 207904 yaeL 7064343 yaeL Escherichia coli O127:H6 str. E2348/69 zinc metallopeptidase RseP YP_002327768.1 206552 D 574521 CDS YP_002327769.1 215485338 7064906 207934..210366 1 NC_011601.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 210366 yaeT 7064906 yaeT Escherichia coli O127:H6 str. E2348/69 outer membrane protein assembly factor YaeT YP_002327769.1 207934 D 574521 CDS YP_002327770.1 215485339 7064910 210488..210973 1 NC_011601.1 periplasmic chaperone 210973 skp 7064910 skp Escherichia coli O127:H6 str. E2348/69 periplasmic chaperone YP_002327770.1 210488 D 574521 CDS YP_002327771.1 215485340 7062719 210977..212002 1 NC_011601.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 212002 lpxD 7062719 lpxD Escherichia coli O127:H6 str. E2348/69 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_002327771.1 210977 D 574521 CDS YP_002327772.1 215485341 7061575 212107..212562 1 NC_011601.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 212562 fabZ 7061575 fabZ Escherichia coli O127:H6 str. E2348/69 (3R)-hydroxymyristoyl-ACP dehydratase YP_002327772.1 212107 D 574521 CDS YP_002327773.1 215485342 7062070 212566..213354 1 NC_011601.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 213354 lpxA 7062070 lpxA Escherichia coli O127:H6 str. E2348/69 UDP-N-acetylglucosamine acyltransferase YP_002327773.1 212566 D 574521 CDS YP_002327774.1 215485343 7061572 213354..214502 1 NC_011601.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 214502 lpxB 7061572 lpxB Escherichia coli O127:H6 str. E2348/69 lipid-A-disaccharide synthase YP_002327774.1 213354 D 574521 CDS YP_002327775.1 215485344 7061573 214499..215095 1 NC_011601.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 215095 rnhB 7061573 rnhB Escherichia coli O127:H6 str. E2348/69 ribonuclease HII YP_002327775.1 214499 D 574521 CDS YP_002327776.1 215485345 7060854 215127..218609 1 NC_011601.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 218609 dnaE 7060854 dnaE Escherichia coli O127:H6 str. E2348/69 DNA polymerase III subunit alpha YP_002327776.1 215127 D 574521 CDS YP_002327777.1 215485346 7065047 218622..219581 1 NC_011601.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 219581 accA 7065047 accA Escherichia coli O127:H6 str. E2348/69 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_002327777.1 218622 D 574521 CDS YP_002327778.1 215485347 7062380 219680..221821 1 NC_011601.1 lysine decarboxylase 2, constitutive 221821 ldcC 7062380 ldcC Escherichia coli O127:H6 str. E2348/69 lysine decarboxylase 2, constitutive YP_002327778.1 219680 D 574521 CDS YP_002327779.1 215485348 7061513 221878..222267 1 NC_011601.1 hypothetical protein 222267 yaeR 7061513 yaeR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327779.1 221878 D 574521 CDS YP_002327780.1 215485349 7064909 222332..223645 1 NC_011601.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 223645 tilS 7064909 tilS Escherichia coli O127:H6 str. E2348/69 tRNA(Ile)-lysidine synthetase YP_002327780.1 222332 D 574521 CDS YP_002327781.1 215485350 7061804 complement(223679..223933) 1 NC_011601.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 223933 rof 7061804 rof Escherichia coli O127:H6 str. E2348/69 Rho-binding antiterminator YP_002327781.1 223679 R 574521 CDS YP_002327782.1 215485351 7061823 complement(223926..224126) 1 NC_011601.1 hypothetical protein 224126 yaeP 7061823 yaeP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327782.1 223926 R 574521 CDS YP_002327783.1 215485352 7064907 224292..224837 1 NC_011601.1 hypothetical protein 224837 yaeQ 7064907 yaeQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327783.1 224292 D 574521 CDS YP_002327784.1 215485353 7064908 224834..225256 1 NC_011601.1 peptidyl-tRNA hydrolase domain-containing protein 225256 yaeJ 7064908 yaeJ Escherichia coli O127:H6 str. E2348/69 peptidyl-tRNA hydrolase domain-containing protein YP_002327784.1 224834 D 574521 CDS YP_002327785.1 215485354 7064905 225270..225980 1 NC_011601.1 lipoprotein involved with copper homeostasis and adhesion 225980 nlpE 7064905 nlpE Escherichia coli O127:H6 str. E2348/69 lipoprotein involved with copper homeostasis and adhesion YP_002327785.1 225270 D 574521 CDS YP_002327786.1 215485355 7065404 complement(226136..226960) 1 NC_011601.1 hypothetical protein 226960 yaeF 7065404 yaeF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327786.1 226136 R 574521 CDS YP_002327787.1 215485356 7064903 complement(227013..228731) 1 NC_011601.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 228731 proS 7064903 proS Escherichia coli O127:H6 str. E2348/69 prolyl-tRNA synthetase YP_002327787.1 227013 R 574521 CDS YP_002327788.1 215485357 7061304 complement(228842..229549) 1 NC_011601.1 hypothetical protein 229549 yaeB 7061304 yaeB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327788.1 228842 R 574521 CDS YP_002327789.1 215485358 7064902 complement(229546..229950) 1 NC_011601.1 outer membrane lipoprotein 229950 rcsF 7064902 rcsF Escherichia coli O127:H6 str. E2348/69 outer membrane lipoprotein YP_002327789.1 229546 R 574521 CDS YP_002327790.1 215485359 7063967 complement(230068..230883) 1 NC_011601.1 DL-methionine transporter substrate-binding subunit 230883 metQ 7063967 metQ Escherichia coli O127:H6 str. E2348/69 DL-methionine transporter substrate-binding subunit YP_002327790.1 230068 R 574521 CDS YP_002327791.1 215485360 7063768 complement(230923..231576) 1 NC_011601.1 part of the MetNIQ methionine uptake system; DL-methionine transporter permease 231576 metI 7063768 metI Escherichia coli O127:H6 str. E2348/69 DL-methionine transporter permease YP_002327791.1 230923 R 574521 CDS YP_002327792.1 215485361 7063763 complement(231569..232600) 1 NC_011601.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 232600 metN 7063763 metN Escherichia coli O127:H6 str. E2348/69 DL-methionine transporter ATP-binding subunit YP_002327792.1 231569 R 574521 CDS YP_002327793.1 215485362 7063767 232788..233360 1 NC_011601.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 233360 gmhB 7063767 gmhB Escherichia coli O127:H6 str. E2348/69 D,D-heptose 1,7-bisphosphate phosphatase YP_002327793.1 232788 D 574521 CDS YP_002327794.1 215485363 7062462 239126..239929 1 NC_011601.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 239929 dkgB 7062462 dkgB Escherichia coli O127:H6 str. E2348/69 2,5-diketo-D-gluconate reductase B YP_002327794.1 239126 D 574521 CDS YP_002327795.1 215485364 7065037 complement(239926..240840) 1 NC_011601.1 DNA-binding transcriptional regulator 240840 yafC 7065037 yafC Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002327795.1 239926 R 574521 CDS YP_002327796.1 215485365 7064911 241081..241881 1 NC_011601.1 hypothetical protein 241881 yafD 7064911 yafD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327796.1 241081 D 574521 CDS YP_002327797.1 215485366 7064912 241959..242729 1 NC_011601.1 S-adenosyl-L-methionine-dependent methyltransferase 242729 yafE 7064912 yafE Escherichia coli O127:H6 str. E2348/69 S-adenosyl-L-methionine-dependent methyltransferase YP_002327797.1 241959 D 574521 CDS YP_002327798.1 215485367 7064913 complement(242778..244136) 1 NC_011601.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D 244136 mltD 7064913 mltD Escherichia coli O127:H6 str. E2348/69 membrane-bound lytic murein transglycosylase D YP_002327798.1 242778 R 574521 CDS YP_002327799.1 215485368 7063797 complement(244208..244963) 1 NC_011601.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 244963 gloB 7063797 gloB Escherichia coli O127:H6 str. E2348/69 hydroxyacylglutathione hydrolase YP_002327799.1 244208 R 574521 CDS YP_002327800.1 215485369 7061691 244997..245719 1 NC_011601.1 S-adenosyl-L-methionine-dependent methyltransferase 245719 yafS 7061691 yafS Escherichia coli O127:H6 str. E2348/69 S-adenosyl-L-methionine-dependent methyltransferase YP_002327800.1 244997 D 574521 CDS YP_002327801.1 215485370 7064918 complement(245716..246183) 1 NC_011601.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 246183 rnhA 7064918 rnhA Escherichia coli O127:H6 str. E2348/69 ribonuclease H YP_002327801.1 245716 R 574521 CDS YP_002327802.1 215485371 7060853 246248..246979 1 NC_011601.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 246979 dnaQ 7060853 dnaQ Escherichia coli O127:H6 str. E2348/69 DNA polymerase III subunit epsilon YP_002327802.1 246248 D 574521 CDS YP_002327803.1 215485372 7062463 complement(247287..248057) 1 NC_011601.1 hypothetical protein 248057 yafV 7062463 yafV Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327803.1 247287 R 574521 CDS YP_002327804.1 215485373 7064919 248211..248684 1 NC_011601.1 inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 248684 ivy 7064919 ivy Escherichia coli O127:H6 str. E2348/69 C-lysozyme inhibitor YP_002327804.1 248211 D 574521 CDS YP_002327805.1 215485374 7063562 complement(248727..251171) 1 NC_011601.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 251171 fadE 7063562 fadE Escherichia coli O127:H6 str. E2348/69 acyl-CoA dehydrogenase YP_002327805.1 248727 R 574521 CDS YP_002327806.1 215485375 7062074 251411..251989 1 NC_011601.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 251989 gmhA 7062074 gmhA Escherichia coli O127:H6 str. E2348/69 phosphoheptose isomerase YP_002327806.1 251411 D 574521 CDS YP_002327807.1 215485376 7061560 252194..252961 1 NC_011601.1 amidotransferase 252961 yafJ 7061560 yafJ Escherichia coli O127:H6 str. E2348/69 amidotransferase YP_002327807.1 252194 D 574521 CDS YP_002327808.1 215485377 7064914 complement(252932..253672) 1 NC_011601.1 hypothetical protein 253672 yafK 7064914 yafK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327808.1 252932 R 574521 CDS YP_002327809.1 215485378 7064915 253975..254733 1 NC_011601.1 lipoprotein 254733 yafL 7064915 yafL Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002327809.1 253975 D 574521 CDS YP_002327810.1 215485379 7064916 complement(254790..255146) 1 NC_011601.1 hypothetical protein 255146 7064916 E2348C_0223 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327810.1 254790 R 574521 CDS YP_002327811.1 215485380 7062109 257206..257991 1 NC_011601.1 hypothetical protein 257991 mbhA 7062109 mbhA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327811.1 257206 D 574521 CDS YP_002327812.1 215485381 7065296 258062..259117 1 NC_011601.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 259117 dinB 7065296 dinB Escherichia coli O127:H6 str. E2348/69 DNA polymerase IV YP_002327812.1 258062 D 574521 CDS YP_002327813.1 215485382 7065028 259114..259566 1 NC_011601.1 hypothetical protein 259566 yafP 7065028 yafP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327813.1 259114 D 574521 CDS YP_002327814.1 215485383 7064917 259757..260896 1 NC_011601.1 mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 260896 7064917 E2348C_0228 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327814.1 259757 D 574521 CDS YP_002327815.1 215485384 7063441 260893..261474 1 NC_011601.1 similar to release factor 1 and 2; peptide chain release factor-like protein 261474 prfH 7063441 prfH Escherichia coli O127:H6 str. E2348/69 peptide chain release factor-like protein YP_002327815.1 260893 D 574521 CDS YP_002327816.1 215485385 7061287 complement(261564..263021) 1 NC_011601.1 aminoacyl-histidine dipeptidase 263021 pepD 7061287 pepD Escherichia coli O127:H6 str. E2348/69 aminoacyl-histidine dipeptidase YP_002327816.1 261564 R 574521 CDS YP_002327817.1 215485386 7060700 263282..263740 1 NC_011601.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 263740 gpt 7060700 gpt Escherichia coli O127:H6 str. E2348/69 xanthine-guanine phosphoribosyltransferase YP_002327817.1 263282 D 574521 CDS YP_002327818.1 215485387 7064238 263832..265076 1 NC_011601.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 265076 frsA 7064238 frsA Escherichia coli O127:H6 str. E2348/69 fermentation/respiration switch protein YP_002327818.1 263832 D 574521 CDS YP_002327819.1 215485388 7061958 265134..265535 1 NC_011601.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 265535 crl 7061958 crl Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator Crl YP_002327819.1 265134 D 574521 CDS YP_002327820.1 215485389 7062846 complement(265574..266629) 1 NC_011601.1 outer membrane phosphoporin protein E 266629 phoE 7062846 phoE Escherichia coli O127:H6 str. E2348/69 outer membrane phosphoporin protein E YP_002327820.1 265574 R 574521 CDS YP_002327821.1 215485390 7060744 266918..268021 1 NC_011601.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 268021 proB 7060744 proB Escherichia coli O127:H6 str. E2348/69 gamma-glutamyl kinase YP_002327821.1 266918 D 574521 CDS YP_002327822.1 215485391 7061297 268033..269286 1 NC_011601.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 269286 proA 7061297 proA Escherichia coli O127:H6 str. E2348/69 gamma-glutamyl phosphate reductase YP_002327822.1 268033 D 574521 CDS YP_002327823.1 215485392 7064961 270037..270375 1 NC_011601.1 transposase Orf1 of IS3 family IS element 270375 7064961 E2348C_0238 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS3 family IS element YP_002327823.1 270037 D 574521 CDS YP_002327824.1 215485393 7064962 271216..272292 1 NC_011601.1 transposase of ISEc21 272292 7064962 E2348C_0240 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc21 YP_002327824.1 271216 D 574521 CDS YP_002327825.1 215485394 7063444 273430..274044 1 NC_011601.1 hypothetical protein 274044 yagU 7063444 yagU Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327825.1 273430 D 574521 CDS YP_002327826.1 215485395 7064920 complement(274293..274622) 1 NC_011601.1 ferredoxin 274622 ykgJ 7064920 ykgJ Escherichia coli O127:H6 str. E2348/69 ferredoxin YP_002327826.1 274293 R 574521 CDS YP_002327827.1 215485396 7062005 complement(274935..275645) 1 NC_011601.1 chaperone 275645 ecpE 7062005 ecpE Escherichia coli O127:H6 str. E2348/69 chaperone YP_002327827.1 274935 R 574521 CDS YP_002327828.1 215485397 7063835 complement(275614..277257) 1 NC_011601.1 hypothetical protein 277257 ecpD 7063835 ecpD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327828.1 275614 R 574521 CDS YP_002327829.1 215485398 7063834 complement(277247..279772) 1 NC_011601.1 outer membrane usher protein 279772 ecpC 7063834 ecpC Escherichia coli O127:H6 str. E2348/69 outer membrane usher protein YP_002327829.1 277247 R 574521 CDS YP_002327830.1 215485399 7063832 complement(279798..280466) 1 NC_011601.1 chaperone 280466 ecpB 7063832 ecpB Escherichia coli O127:H6 str. E2348/69 chaperone YP_002327830.1 279798 R 574521 CDS YP_002327831.1 215485400 7063831 complement(280523..281110) 1 NC_011601.1 fimbrillin precursor 281110 ecpA 7063831 ecpA Escherichia coli O127:H6 str. E2348/69 fimbrillin precursor YP_002327831.1 280523 R 574521 CDS YP_002327832.1 215485401 7063830 complement(281184..281774) 1 NC_011601.1 regulator 281774 ecpR 7063830 ecpR Escherichia coli O127:H6 str. E2348/69 regulator YP_002327832.1 281184 R 574521 CDS YP_002327833.1 215485402 7063836 282198..282488 1 NC_011601.1 hypothetical protein 282488 7063836 E2348C_0251 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327833.1 282198 D 574521 CDS YP_002327834.1 215485403 7062006 complement(282810..282950) 1 NC_011601.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 282950 rpmJ 7062006 rpmJ Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L36 YP_002327834.1 282810 R 574521 CDS YP_002327835.1 215485404 7062008 complement(282950..283213) 1 NC_011601.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 283213 rpmE2 7062008 rpmE2 Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L31 YP_002327835.1 282950 R 574521 CDS YP_002327836.1 215485405 7062007 complement(284152..285294) 1 NC_011601.1 NADH-dependent flavin oxidoreductase 285294 7062007 E2348C_0255 Escherichia coli O127:H6 str. E2348/69 NADH-dependent flavin oxidoreductase YP_002327836.1 284152 R 574521 CDS YP_002327837.1 215485406 7063446 complement(285466..286386) 1 NC_011601.1 hydrolases 286386 7063446 E2348C_0256 Escherichia coli O127:H6 str. E2348/69 hydrolases YP_002327837.1 285466 R 574521 CDS YP_002327838.1 215485407 7063447 286543..287469 1 NC_011601.1 transcriptional regulator 287469 7063447 E2348C_0257 Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002327838.1 286543 D 574521 CDS YP_002327839.1 215485408 7063448 287669..288562 1 NC_011601.1 DNA-binding transcriptional regulator 288562 7063448 E2348C_0258 Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002327839.1 287669 D 574521 CDS YP_002327840.1 215485409 7063449 complement(288593..289582) 1 NC_011601.1 aldo/keto reductase 289582 7063449 E2348C_0259 Escherichia coli O127:H6 str. E2348/69 aldo/keto reductase YP_002327840.1 288593 R 574521 CDS YP_002327841.1 215485410 7063450 complement(289609..290460) 1 NC_011601.1 aldo/keto reductases, related to diketogulonate reductase 290460 7063450 E2348C_0260 Escherichia coli O127:H6 str. E2348/69 aldo/keto reductases, related to diketogulonate reductase YP_002327841.1 289609 R 574521 CDS YP_002327842.1 215485411 7063451 291026..295276 1 NC_011601.1 adhesin/invasin 295276 7063451 E2348C_0261 Escherichia coli O127:H6 str. E2348/69 adhesin/invasin YP_002327842.1 291026 D 574521 CDS YP_002327843.1 215485412 7063452 complement(295401..296258) 1 NC_011601.1 DNA-binding transcriptional regulator, AraC-type 296258 ykgA 7063452 ykgA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator, AraC-type YP_002327843.1 295401 R 574521 CDS YP_002327844.1 215485413 7061996 296506..297375 1 NC_011601.1 reductase 297375 7061996 E2348C_0263 Escherichia coli O127:H6 str. E2348/69 reductase YP_002327844.1 296506 D 574521 CDS YP_002327845.1 215485414 7063453 complement(297535..298128) 1 NC_011601.1 hypothetical protein 298128 ykgB 7063453 ykgB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327845.1 297535 R 574521 CDS YP_002327846.1 215485415 7061997 complement(298140..298376) 1 NC_011601.1 hypothetical protein 298376 ykgI 7061997 ykgI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327846.1 298140 R 574521 CDS YP_002327847.1 215485416 7062004 complement(298485..299810) 1 NC_011601.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 299810 ykgC 7062004 ykgC Escherichia coli O127:H6 str. E2348/69 pyridine nucleotide-disulfide oxidoreductase YP_002327847.1 298485 R 574521 CDS YP_002327848.1 215485417 7061998 300037..300891 1 NC_011601.1 DNA-binding transcriptional regulator 300891 ykgD 7061998 ykgD Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002327848.1 300037 D 574521 CDS YP_002327849.1 215485418 7061999 301419..302138 1 NC_011601.1 oxidoreductase 302138 ykgE 7061999 ykgE Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002327849.1 301419 D 574521 CDS YP_002327850.1 215485419 7062000 302149..303576 1 NC_011601.1 amino acid dehydrogenase with NAD(P)-binding domain and ferridoxin-like domain 303576 ykgF 7062000 ykgF Escherichia coli O127:H6 str. E2348/69 amino acid dehydrogenase with NAD(P)-binding domain and ferridoxin-like domain YP_002327850.1 302149 D 574521 CDS YP_002327851.1 215485420 7062001 303569..304264 1 NC_011601.1 transporter 304264 ykgG 7062001 ykgG Escherichia coli O127:H6 str. E2348/69 transporter YP_002327851.1 303569 D 574521 CDS YP_002327852.1 215485421 7062002 complement(304219..304431) 1 NC_011601.1 hypothetical protein 304431 7062002 E2348C_0271 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327852.1 304219 R 574521 CDS YP_002327853.1 215485422 7062003 complement(305220..306890) 1 NC_011601.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 306890 betA 7062003 betA Escherichia coli O127:H6 str. E2348/69 choline dehydrogenase YP_002327853.1 305220 R 574521 CDS YP_002327854.1 215485423 7062506 complement(306904..308376) 1 NC_011601.1 catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase 308376 betB 7062506 betB Escherichia coli O127:H6 str. E2348/69 betaine aldehyde dehydrogenase YP_002327854.1 306904 R 574521 CDS YP_002327855.1 215485424 7062507 complement(308390..308977) 1 NC_011601.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI 308977 betI 7062507 betI Escherichia coli O127:H6 str. E2348/69 transcriptional regulator BetI YP_002327855.1 308390 R 574521 CDS YP_002327856.1 215485425 7062508 309106..311139 1 NC_011601.1 proton-motive-force-driven choline transporter; choline transport protein BetT 311139 betT 7062508 betT Escherichia coli O127:H6 str. E2348/69 choline transport protein BetT YP_002327856.1 309106 D 574521 CDS YP_002327857.1 215485426 7062509 312017..313105 1 NC_011601.1 DNA-binding transcriptional regulator 313105 yahA 7062509 yahA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002327857.1 312017 D 574521 CDS YP_002327858.1 215485427 7064921 complement(313147..314079) 1 NC_011601.1 DNA-binding transcriptional regulator 314079 yahB 7064921 yahB Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002327858.1 313147 R 574521 CDS YP_002327859.1 215485428 7064922 complement(314171..314668) 1 NC_011601.1 hypothetical protein 314668 yahC 7064922 yahC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327859.1 314171 R 574521 CDS YP_002327860.1 215485429 7062705 314926..315531 1 NC_011601.1 transcriptional regulator with ankyrin domain 315531 yahD 7062705 yahD Escherichia coli O127:H6 str. E2348/69 transcriptional regulator with ankyrin domain YP_002327860.1 314926 D 574521 CDS YP_002327861.1 215485430 7062706 315571..316434 1 NC_011601.1 hypothetical protein 316434 yahE 7062706 yahE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327861.1 315571 D 574521 CDS YP_002327862.1 215485431 7063664 316424..317971 1 NC_011601.1 acyl-CoA synthetase with NAD(P)-binding domain and succinyl-CoA synthetase domain 317971 yahF 7063664 yahF Escherichia coli O127:H6 str. E2348/69 acyl-CoA synthetase with NAD(P)-binding domain and succinyl-CoA synthetase domain YP_002327862.1 316424 D 574521 CDS YP_002327863.1 215485432 7063669 317971..319389 1 NC_011601.1 hypothetical protein 319389 yahG 7063669 yahG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327863.1 317971 D 574521 CDS YP_002327864.1 215485433 7063670 319415..319687 1 NC_011601.1 hypothetical protein 319687 yahH 7063670 yahH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327864.1 319415 D 574521 CDS YP_002327865.1 215485434 7063671 319719..320669 1 NC_011601.1 carbamate kinase 320669 yahI 7063671 yahI Escherichia coli O127:H6 str. E2348/69 carbamate kinase YP_002327865.1 319719 D 574521 CDS YP_002327866.1 215485435 7063672 320679..322061 1 NC_011601.1 metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; deaminase 322061 yahJ 7063672 yahJ Escherichia coli O127:H6 str. E2348/69 deaminase YP_002327866.1 320679 D 574521 CDS YP_002327867.1 215485436 7063674 complement(324364..325038) 1 NC_011601.1 neutral amino-acid efflux system 325038 yahN 7063674 yahN Escherichia coli O127:H6 str. E2348/69 neutral amino-acid efflux system YP_002327867.1 324364 R 574521 CDS YP_002327868.1 215485437 7063675 325185..325460 1 NC_011601.1 hypothetical protein 325460 yahO 7063675 yahO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327868.1 325185 D 574521 CDS YP_002327869.1 215485438 7063676 complement(325561..327147) 1 NC_011601.1 DNA-binding transcriptional activator 327147 prpR 7063676 prpR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator YP_002327869.1 325561 R 574521 CDS YP_002327870.1 215485439 7061313 327386..328267 1 NC_011601.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 328267 prpB 7061313 prpB Escherichia coli O127:H6 str. E2348/69 2-methylisocitrate lyase YP_002327870.1 327386 D 574521 CDS YP_002327871.1 215485440 7061309 328436..329605 1 NC_011601.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 329605 prpC 7061309 prpC Escherichia coli O127:H6 str. E2348/69 methylcitrate synthase YP_002327871.1 328436 D 574521 CDS YP_002327872.1 215485441 7061310 329639..331090 1 NC_011601.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 331090 prpD 7061310 prpD Escherichia coli O127:H6 str. E2348/69 2-methylcitrate dehydratase YP_002327872.1 329639 D 574521 CDS YP_002327873.1 215485442 7061311 331130..332941 1 NC_011601.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 332941 prpE 7061311 prpE Escherichia coli O127:H6 str. E2348/69 propionyl-CoA synthetase YP_002327873.1 331130 D 574521 CDS YP_002327874.1 215485443 7061312 333266..334525 1 NC_011601.1 cytosine permease 334525 codB 7061312 codB Escherichia coli O127:H6 str. E2348/69 cytosine permease YP_002327874.1 333266 D 574521 CDS YP_002327875.1 215485444 7062830 334515..335798 1 NC_011601.1 Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 335798 codA 7062830 codA Escherichia coli O127:H6 str. E2348/69 cytosine deaminase YP_002327875.1 334515 D 574521 CDS YP_002327876.1 215485445 7062829 complement(335919..336530) 1 NC_011601.1 transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase 336530 lacA 7062829 lacA Escherichia coli O127:H6 str. E2348/69 galactoside O-acetyltransferase YP_002327876.1 335919 R 574521 CDS YP_002327877.1 215485446 7061508 complement(336596..337849) 1 NC_011601.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 337849 lacY 7061508 lacY Escherichia coli O127:H6 str. E2348/69 galactoside permease YP_002327877.1 336596 R 574521 CDS YP_002327878.1 215485447 7061510 complement(337901..340975) 1 NC_011601.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase 340975 lacZ 7061510 lacZ Escherichia coli O127:H6 str. E2348/69 beta-D-galactosidase YP_002327878.1 337901 R 574521 CDS YP_002327879.1 215485448 7061511 complement(341098..342180) 1 NC_011601.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor 342180 lacI 7061511 lacI Escherichia coli O127:H6 str. E2348/69 lac repressor YP_002327879.1 341098 R 574521 CDS YP_002327880.1 215485449 7061509 342382..342921 1 NC_011601.1 nucleoprotein/polynucleotide-associated enzyme 342921 yaiL 7061509 yaiL Escherichia coli O127:H6 str. E2348/69 nucleoprotein/polynucleotide-associated enzyme YP_002327880.1 342382 D 574521 CDS YP_002327881.1 215485450 7063680 complement(343047..343880) 1 NC_011601.1 esterase 343880 frmB 7063680 frmB Escherichia coli O127:H6 str. E2348/69 esterase YP_002327881.1 343047 R 574521 CDS YP_002327882.1 215485451 7061955 complement(343973..345082) 1 NC_011601.1 alcohol dehydrogenase 345082 frmA 7061955 frmA Escherichia coli O127:H6 str. E2348/69 alcohol dehydrogenase YP_002327882.1 343973 R 574521 CDS YP_002327883.1 215485452 7061954 complement(345117..345392) 1 NC_011601.1 formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR 345392 frmR 7061954 frmR Escherichia coli O127:H6 str. E2348/69 regulator protein FrmR YP_002327883.1 345117 R 574521 CDS YP_002327884.1 215485453 7061956 345698..346660 1 NC_011601.1 with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 346660 tauA 7061956 tauA Escherichia coli O127:H6 str. E2348/69 taurine transporter substrate binding subunit YP_002327884.1 345698 D 574521 CDS YP_002327885.1 215485454 7061760 346673..347440 1 NC_011601.1 Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 347440 tauB 7061760 tauB Escherichia coli O127:H6 str. E2348/69 taurine transporter ATP-binding subunit YP_002327885.1 346673 D 574521 CDS YP_002327886.1 215485455 7061761 347437..348264 1 NC_011601.1 taurine transporter subunit 348264 tauC 7061761 tauC Escherichia coli O127:H6 str. E2348/69 taurine transporter subunit YP_002327886.1 347437 D 574521 CDS YP_002327887.1 215485456 7061762 348261..349112 1 NC_011601.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 349112 tauD 7061762 tauD Escherichia coli O127:H6 str. E2348/69 taurine dioxygenase YP_002327887.1 348261 D 574521 CDS YP_002327888.1 215485457 7061763 complement(349152..350126) 1 NC_011601.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 350126 hemB 7061763 hemB Escherichia coli O127:H6 str. E2348/69 delta-aminolevulinic acid dehydratase YP_002327888.1 349152 R 574521 CDS YP_002327889.1 215485458 7063681 353654..354277 1 NC_011601.1 DNA-binding transcriptional regulator 354277 yaiV 7063681 yaiV Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002327889.1 353654 D 574521 CDS YP_002327890.1 215485459 7063682 complement(354278..355435) 1 NC_011601.1 this protein has no known enzymatic function; beta-lactam binding protein AmpH 355435 ampH 7063682 ampH Escherichia coli O127:H6 str. E2348/69 beta-lactam binding protein AmpH YP_002327890.1 354278 R 574521 CDS YP_002327891.1 215485460 7061340 355787..357007 1 NC_011601.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transporter 357007 sbmA 7061340 sbmA Escherichia coli O127:H6 str. E2348/69 transporter YP_002327891.1 355787 D 574521 CDS YP_002327892.1 215485461 7063683 complement(358181..358489) 1 NC_011601.1 hypothetical protein 358489 yaiY 7063683 yaiY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327892.1 358181 R 574521 CDS YP_002327893.1 215485462 7063684 358749..358961 1 NC_011601.1 hypothetical protein 358961 yaiZ 7063684 yaiZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327893.1 358749 D 574521 CDS YP_002327894.1 215485463 7063685 complement(358985..360079) 1 NC_011601.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 360079 ddl 7063685 ddl Escherichia coli O127:H6 str. E2348/69 D-alanyl-alanine synthetase A YP_002327894.1 358985 R 574521 CDS YP_002327895.1 215485464 7065237 360542..360802 1 NC_011601.1 hypothetical protein 360802 iraP 7065237 iraP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327895.1 360542 D 574521 CDS YP_002327896.1 215485465 7063545 360903..362318 1 NC_011601.1 alkaline phosphatase 362318 phoA 7063545 phoA Escherichia coli O127:H6 str. E2348/69 alkaline phosphatase YP_002327896.1 360903 D 574521 CDS YP_002327897.1 215485466 7060742 362437..362757 1 NC_011601.1 hypothetical protein 362757 psiF 7060742 psiF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327897.1 362437 D 574521 CDS YP_002327898.1 215485467 7061317 362859..363974 1 NC_011601.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 363974 adrA 7061317 adrA Escherichia coli O127:H6 str. E2348/69 diguanylate cyclase AdrA YP_002327898.1 362859 D 574521 CDS YP_002327899.1 215485468 7062412 complement(363991..364800) 1 NC_011601.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 364800 proC 7062412 proC Escherichia coli O127:H6 str. E2348/69 pyrroline-5-carboxylate reductase YP_002327899.1 363991 R 574521 CDS YP_002327900.1 215485469 7061298 364920..365378 1 NC_011601.1 hypothetical protein 365378 yaiI 7061298 yaiI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327900.1 364920 D 574521 CDS YP_002327901.1 215485470 7063679 365561..366085 1 NC_011601.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 366085 aroL 7063679 aroL Escherichia coli O127:H6 str. E2348/69 shikimate kinase YP_002327901.1 365561 D 574521 CDS YP_002327902.1 215485471 7061398 366135..366326 1 NC_011601.1 hypothetical protein 366326 yaiA 7061398 yaiA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327902.1 366135 D 574521 CDS YP_002327903.1 215485472 7063677 366584..367261 1 NC_011601.1 hypothetical protein 367261 aroM 7063677 aroM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327903.1 366584 D 574521 CDS YP_002327904.1 215485473 7061399 367333..367617 1 NC_011601.1 hypothetical protein 367617 yaiE 7061399 yaiE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327904.1 367333 D 574521 CDS YP_002327905.1 215485474 7063678 367825..368103 1 NC_011601.1 hypothetical protein 368103 ykiA 7063678 ykiA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327905.1 367825 D 574521 CDS YP_002327906.1 215485475 7062009 complement(368261..369172) 1 NC_011601.1 Required for efficient pilin antigenic variation; recombination associated protein 369172 rdgC 7062009 rdgC Escherichia coli O127:H6 str. E2348/69 recombination associated protein YP_002327906.1 368261 R 574521 CDS YP_002327907.1 215485476 7063969 369297..370205 1 NC_011601.1 catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 370205 mak 7063969 mak Escherichia coli O127:H6 str. E2348/69 fructokinase YP_002327907.1 369297 D 574521 CDS YP_002327908.1 215485477 7065269 complement(370343..371527) 1 NC_011601.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ 371527 araJ 7065269 araJ Escherichia coli O127:H6 str. E2348/69 MFS transport protein AraJ YP_002327908.1 370343 R 574521 CDS YP_002327909.1 215485478 7061362 complement(371653..374796) 1 NC_011601.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease SbcC 374796 sbcC 7061362 sbcC Escherichia coli O127:H6 str. E2348/69 exonuclease SbcC YP_002327909.1 371653 R 574521 CDS YP_002327910.1 215485479 7065333 complement(374793..375995) 1 NC_011601.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease SbcD 375995 sbcD 7065333 sbcD Escherichia coli O127:H6 str. E2348/69 exonuclease SbcD YP_002327910.1 374793 R 574521 CDS YP_002327911.1 215485480 7065334 376185..376874 1 NC_011601.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 376874 phoB 7065334 phoB Escherichia coli O127:H6 str. E2348/69 transcriptional regulator PhoB YP_002327911.1 376185 D 574521 CDS YP_002327912.1 215485481 7060743 376932..378227 1 NC_011601.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 378227 phoR 7060743 phoR Escherichia coli O127:H6 str. E2348/69 phosphate regulon sensor protein YP_002327912.1 376932 D 574521 CDS YP_002327913.1 215485482 7060748 378634..379953 1 NC_011601.1 branched chain amino acid transporter (LIV-II) 379953 brnQ 7060748 brnQ Escherichia coli O127:H6 str. E2348/69 branched chain amino acid transporter (LIV-II) YP_002327913.1 378634 D 574521 CDS YP_002327914.1 215485483 7062531 380029..381402 1 NC_011601.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; permease 381402 proY 7062531 proY Escherichia coli O127:H6 str. E2348/69 permease YP_002327914.1 380029 D 574521 CDS YP_002327915.1 215485484 7061308 381558..383375 1 NC_011601.1 maltodextrin glucosidase 383375 malZ 7061308 malZ Escherichia coli O127:H6 str. E2348/69 maltodextrin glucosidase YP_002327915.1 381558 D 574521 CDS YP_002327916.1 215485485 7065282 complement(383380..383961) 1 NC_011601.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; ACP phosphodieterase 383961 acpH 7065282 acpH Escherichia coli O127:H6 str. E2348/69 ACP phosphodieterase YP_002327916.1 383380 R 574521 CDS YP_002327917.1 215485486 7062392 384180..385250 1 NC_011601.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 385250 queA 7062392 queA Escherichia coli O127:H6 str. E2348/69 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_002327917.1 384180 D 574521 CDS YP_002327918.1 215485487 7063943 385305..386432 1 NC_011601.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 386432 tgt 7063943 tgt Escherichia coli O127:H6 str. E2348/69 queuine tRNA-ribosyltransferase YP_002327918.1 385305 D 574521 CDS YP_002327919.1 215485488 7061779 386455..386787 1 NC_011601.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 386787 yajC 7061779 yajC Escherichia coli O127:H6 str. E2348/69 preprotein translocase subunit YajC YP_002327919.1 386455 D 574521 CDS YP_002327920.1 215485489 7063686 386815..388662 1 NC_011601.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 388662 secD 7063686 secD Escherichia coli O127:H6 str. E2348/69 preprotein translocase subunit SecD YP_002327920.1 386815 D 574521 CDS YP_002327921.1 215485490 7065354 388673..389644 1 NC_011601.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 389644 secF 7065354 secF Escherichia coli O127:H6 str. E2348/69 preprotein translocase subunit SecF YP_002327921.1 388673 D 574521 CDS YP_002327922.1 215485491 7065356 389773..390120 1 NC_011601.1 hypothetical protein 390120 yajD 7065356 yajD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327922.1 389773 D 574521 CDS YP_002327923.1 215485492 7063687 complement(390158..391042) 1 NC_011601.1 nucleoside channel phage T6/colicin K receptor 391042 tsx 7063687 tsx Escherichia coli O127:H6 str. E2348/69 nucleoside channel phage T6/colicin K receptor YP_002327923.1 390158 R 574521 CDS YP_002327924.1 215485493 7062273 complement(391341..391880) 1 NC_011601.1 hypothetical protein 391880 yajI 7062273 yajI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327924.1 391341 R 574521 CDS YP_002327925.1 215485494 7063689 392031..392480 1 NC_011601.1 transcriptional regulator NrdR 392480 nrdR 7063689 nrdR Escherichia coli O127:H6 str. E2348/69 transcriptional regulator NrdR YP_002327925.1 392031 D 574521 CDS YP_002327926.1 215485495 7065417 392484..393587 1 NC_011601.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 393587 ribD 7065417 ribD Escherichia coli O127:H6 str. E2348/69 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase YP_002327926.1 392484 D 574521 CDS YP_002327927.1 215485496 7060821 393676..394146 1 NC_011601.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 394146 ribH 7060821 ribH Escherichia coli O127:H6 str. E2348/69 6,7-dimethyl-8-ribityllumazine synthase YP_002327927.1 393676 D 574521 CDS YP_002327928.1 215485497 7060822 394166..394585 1 NC_011601.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 394585 nusB 7060822 nusB Escherichia coli O127:H6 str. E2348/69 transcription antitermination protein NusB YP_002327928.1 394166 D 574521 CDS YP_002327929.1 215485498 7062869 394663..395640 1 NC_011601.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 395640 thiL 7062869 thiL Escherichia coli O127:H6 str. E2348/69 thiamine monophosphate kinase YP_002327929.1 394663 D 574521 CDS YP_002327930.1 215485499 7061788 395618..396136 1 NC_011601.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 396136 pgpA 7061788 pgpA Escherichia coli O127:H6 str. E2348/69 phosphatidylglycerophosphatase A YP_002327930.1 395618 D 574521 CDS YP_002327931.1 215485500 7060717 complement(396190..397164) 1 NC_011601.1 2-carboxybenzaldehyde reductase 397164 yajO 7060717 yajO Escherichia coli O127:H6 str. E2348/69 2-carboxybenzaldehyde reductase YP_002327931.1 396190 R 574521 CDS YP_002327932.1 215485501 7063691 complement(397219..399081) 1 NC_011601.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 399081 dxs 7063691 dxs Escherichia coli O127:H6 str. E2348/69 1-deoxy-D-xylulose-5-phosphate synthase YP_002327932.1 397219 R 574521 CDS YP_002327933.1 215485502 7065076 complement(399106..400005) 1 NC_011601.1 geranyltranstransferase 400005 ispA 7065076 ispA Escherichia coli O127:H6 str. E2348/69 geranyltranstransferase YP_002327933.1 399106 R 574521 CDS YP_002327934.1 215485503 7063551 complement(400005..400247) 1 NC_011601.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 400247 xseB 7063551 xseB Escherichia coli O127:H6 str. E2348/69 exodeoxyribonuclease VII small subunit YP_002327934.1 400005 R 574521 CDS YP_002327935.1 215485504 7064867 400453..401901 1 NC_011601.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 401901 thiI 7064867 thiI Escherichia coli O127:H6 str. E2348/69 thiamine biosynthesis protein ThiI YP_002327935.1 400453 D 574521 CDS YP_002327936.1 215485505 7061786 complement(401955..402545) 1 NC_011601.1 DJ-1 family protein 402545 yajL 7061786 yajL Escherichia coli O127:H6 str. E2348/69 DJ-1 family protein YP_002327936.1 401955 R 574521 CDS YP_002327937.1 215485506 7063690 complement(402508..403419) 1 NC_011601.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 403419 panE 7063690 panE Escherichia coli O127:H6 str. E2348/69 2-dehydropantoate 2-reductase YP_002327937.1 402508 R 574521 CDS YP_002327938.1 215485507 7062909 403587..404078 1 NC_011601.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 404078 yajQ 7062909 yajQ Escherichia coli O127:H6 str. E2348/69 nucleotide-binding protein YP_002327938.1 403587 D 574521 CDS YP_002327939.1 215485508 7063692 complement(404206..405570) 1 NC_011601.1 transporter 405570 yajR 7063692 yajR Escherichia coli O127:H6 str. E2348/69 transporter YP_002327939.1 404206 R 574521 CDS YP_002327940.1 215485509 7063693 complement(405719..406609) 1 NC_011601.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 406609 cyoE 7063693 cyoE Escherichia coli O127:H6 str. E2348/69 protoheme IX farnesyltransferase YP_002327940.1 405719 R 574521 CDS YP_002327941.1 215485510 7065192 complement(406621..406950) 1 NC_011601.1 cytochrome o ubiquinol oxidase subunit IV 406950 cyoD 7065192 cyoD Escherichia coli O127:H6 str. E2348/69 cytochrome o ubiquinol oxidase subunit IV YP_002327941.1 406621 R 574521 CDS YP_002327942.1 215485511 7065191 complement(406950..407564) 1 NC_011601.1 cytochrome o ubiquinol oxidase subunit III 407564 cyoC 7065191 cyoC Escherichia coli O127:H6 str. E2348/69 cytochrome o ubiquinol oxidase subunit III YP_002327942.1 406950 R 574521 CDS YP_002327943.1 215485512 7065190 complement(407554..409545) 1 NC_011601.1 cytochrome o ubiquinol oxidase subunit I 409545 cyoB 7065190 cyoB Escherichia coli O127:H6 str. E2348/69 cytochrome o ubiquinol oxidase subunit I YP_002327943.1 407554 R 574521 CDS YP_002327944.1 215485513 7065189 complement(409567..410514) 1 NC_011601.1 cytochrome o ubiquinol oxidase subunit II 410514 cyoA 7065189 cyoA Escherichia coli O127:H6 str. E2348/69 cytochrome o ubiquinol oxidase subunit II YP_002327944.1 409567 R 574521 CDS YP_002327945.1 215485514 7065188 complement(410974..412449) 1 NC_011601.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 412449 ampG 7065188 ampG Escherichia coli O127:H6 str. E2348/69 muropeptide transporter YP_002327945.1 410974 R 574521 CDS YP_002327946.1 215485515 7062624 complement(412493..413071) 1 NC_011601.1 hypothetical protein 413071 yajG 7062624 yajG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327946.1 412493 R 574521 CDS YP_002327947.1 215485516 7063688 413376..413693 1 NC_011601.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 413693 bolA 7063688 bolA Escherichia coli O127:H6 str. E2348/69 transcriptional regulator BolA YP_002327947.1 413376 D 574521 CDS YP_002327948.1 215485517 7062530 414037..415335 1 NC_011601.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 415335 tig 7062530 tig Escherichia coli O127:H6 str. E2348/69 trigger factor YP_002327948.1 414037 D 574521 CDS YP_002327949.1 215485518 7061803 415581..416204 1 NC_011601.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 416204 clpP 7061803 clpP Escherichia coli O127:H6 str. E2348/69 ATP-dependent Clp protease proteolytic subunit YP_002327949.1 415581 D 574521 CDS YP_002327950.1 215485519 7062810 416330..417604 1 NC_011601.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 417604 clpX 7062810 clpX Escherichia coli O127:H6 str. E2348/69 ATP-dependent protease ATP-binding subunit ClpX YP_002327950.1 416330 D 574521 CDS YP_002327951.1 215485520 7062812 417793..420147 1 NC_011601.1 DNA-binding ATP-dependent protease La 420147 lon 7062812 lon Escherichia coli O127:H6 str. E2348/69 DNA-binding ATP-dependent protease La YP_002327951.1 417793 D 574521 CDS YP_002327952.1 215485521 7061559 420356..420628 1 NC_011601.1 histone-like DNA-binding protein; transcriptional regulator HU subunit beta 420628 hupB 7061559 hupB Escherichia coli O127:H6 str. E2348/69 transcriptional regulator HU subunit beta YP_002327952.1 420356 D 574521 CDS YP_002327953.1 215485522 7062194 420820..422691 1 NC_011601.1 peptidyl-prolyl cis-trans isomerase 422691 ppiD 7062194 ppiD Escherichia coli O127:H6 str. E2348/69 peptidyl-prolyl cis-trans isomerase YP_002327953.1 420820 D 574521 CDS YP_002327954.1 215485523 7061273 422842..423213 1 NC_011601.1 hypothetical protein 423213 ybaV 7061273 ybaV Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327954.1 422842 D 574521 CDS YP_002327955.1 215485524 7063707 423319..423717 1 NC_011601.1 hypothetical protein 423717 ybaW 7063707 ybaW Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327955.1 423319 D 574521 CDS YP_002327956.1 215485525 7063708 complement(423769..424464) 1 NC_011601.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC 424464 queC 7063708 queC Escherichia coli O127:H6 str. E2348/69 queuosine biosynthesis protein QueC YP_002327956.1 423769 R 574521 CDS YP_002327957.1 215485526 7063944 complement(424529..426229) 1 NC_011601.1 transporter subunit: periplasmic-binding component of ABC superfamily 426229 ybaE 7063944 ybaE Escherichia coli O127:H6 str. E2348/69 transporter subunit: periplasmic-binding component of ABC superfamily YP_002327957.1 424529 R 574521 CDS YP_002327958.1 215485527 7063696 426329..427147 1 NC_011601.1 thiamin pyrimidine pyrophosphate hydrolase 427147 cof 7063696 cof Escherichia coli O127:H6 str. E2348/69 thiamin pyrimidine pyrophosphate hydrolase YP_002327958.1 426329 D 574521 CDS YP_002327959.1 215485528 7062831 427300..427758 1 NC_011601.1 DNA-binding transcriptional regulator 427758 ybaO 7062831 ybaO Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002327959.1 427300 D 574521 CDS YP_002327960.1 215485529 7063702 427788..429560 1 NC_011601.1 multidrug transporter membrane\ATP-binding components 429560 mdlA 7063702 mdlA Escherichia coli O127:H6 str. E2348/69 multidrug transporter membrane\ATP-binding components YP_002327960.1 427788 D 574521 CDS YP_002327961.1 215485530 7065299 429553..431334 1 NC_011601.1 multidrug transporter membrane\ATP-binding components 431334 mdlB 7065299 mdlB Escherichia coli O127:H6 str. E2348/69 multidrug transporter membrane\ATP-binding components YP_002327961.1 429553 D 574521 CDS YP_002327962.1 215485531 7065300 431515..431853 1 NC_011601.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 431853 glnK 7065300 glnK Escherichia coli O127:H6 str. E2348/69 nitrogen regulatory protein P-II 2 YP_002327962.1 431515 D 574521 CDS YP_002327963.1 215485532 7061682 431883..433169 1 NC_011601.1 ammonium transporter 433169 amtB 7061682 amtB Escherichia coli O127:H6 str. E2348/69 ammonium transporter YP_002327963.1 431883 D 574521 CDS YP_002327964.1 215485533 7061341 complement(433218..434078) 1 NC_011601.1 acyl-CoA thioesterase 434078 tesB 7061341 tesB Escherichia coli O127:H6 str. E2348/69 acyl-CoA thioesterase YP_002327964.1 433218 R 574521 CDS YP_002327965.1 215485534 7061777 434296..434868 1 NC_011601.1 outer membrane lipoprotein 434868 ybaY 7061777 ybaY Escherichia coli O127:H6 str. E2348/69 outer membrane lipoprotein YP_002327965.1 434296 D 574521 CDS YP_002327966.1 215485535 7064964 435058..436431 1 NC_011601.1 transposase of ISEc13 436431 7064964 E2348C_0389 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002327966.1 435058 D 574521 CDS YP_002327967.1 215485536 7063455 complement(436457..436846) 1 NC_011601.1 methyltransferase 436846 ybaZ 7063455 ybaZ Escherichia coli O127:H6 str. E2348/69 methyltransferase YP_002327967.1 436457 R 574521 CDS YP_002327968.1 215485537 7062108 437147..437500 1 NC_011601.1 hypothetical protein 437500 ybaA 7062108 ybaA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327968.1 437147 D 574521 CDS YP_002327969.1 215485538 7063694 complement(437542..439092) 1 NC_011601.1 hypothetical protein 439092 ylaB 7063694 ylaB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327969.1 437542 R 574521 CDS YP_002327970.1 215485539 7062010 complement(439256..439726) 1 NC_011601.1 hypothetical protein 439726 ylaC 7062010 ylaC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327970.1 439256 R 574521 CDS YP_002327971.1 215485540 7065264 complement(440568..440786) 1 NC_011601.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein 440786 hha 7065264 hha Escherichia coli O127:H6 str. E2348/69 hemolysin expression-modulating protein YP_002327971.1 440568 R 574521 CDS YP_002327972.1 215485541 7062060 complement(440812..441186) 1 NC_011601.1 hypothetical protein 441186 ybaJ 7062060 ybaJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327972.1 440812 R 574521 CDS YP_002327973.1 215485542 7063697 complement(441731..444880) 1 NC_011601.1 multidrug efflux system protein 444880 acrB 7063697 acrB Escherichia coli O127:H6 str. E2348/69 multidrug efflux system protein YP_002327973.1 441731 R 574521 CDS YP_002327974.1 215485543 7062397 complement(444903..446096) 1 NC_011601.1 multidrug efflux system 446096 acrA 7062397 acrA Escherichia coli O127:H6 str. E2348/69 multidrug efflux system YP_002327974.1 444903 R 574521 CDS YP_002327975.1 215485544 7062396 446238..446885 1 NC_011601.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 446885 acrR 7062396 acrR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor AcrR YP_002327975.1 446238 D 574521 CDS YP_002327976.1 215485545 7062401 447013..450375 1 NC_011601.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 450375 kefA 7062401 kefA Escherichia coli O127:H6 str. E2348/69 potassium efflux protein KefA YP_002327976.1 447013 D 574521 CDS YP_002327977.1 215485546 7063584 complement(450587..450748) 1 NC_011601.1 hypothetical protein 450748 ybaM 7063584 ybaM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327977.1 450587 R 574521 CDS YP_002327978.1 215485547 7063700 complement(450762..451289) 1 NC_011601.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' 451289 priC 7063700 priC Escherichia coli O127:H6 str. E2348/69 primosomal replication protein N'' YP_002327978.1 450762 R 574521 CDS YP_002327979.1 215485548 7061290 451359..451736 1 NC_011601.1 hypothetical protein 451736 ybaN 7061290 ybaN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327979.1 451359 D 574521 CDS YP_002327980.1 215485549 7063701 451889..452440 1 NC_011601.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 452440 apt 7063701 apt Escherichia coli O127:H6 str. E2348/69 adenine phosphoribosyltransferase YP_002327980.1 451889 D 574521 CDS YP_002327981.1 215485550 7061354 452569..454500 1 NC_011601.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 454500 dnaX 7061354 dnaX Escherichia coli O127:H6 str. E2348/69 DNA polymerase III subunits gamma and tau YP_002327981.1 452569 D 574521 CDS YP_002327982.1 215485551 7065054 454553..454882 1 NC_011601.1 hypothetical protein 454882 ybaB 7065054 ybaB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327982.1 454553 D 574521 CDS YP_002327983.1 215485552 7063695 454882..455487 1 NC_011601.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 455487 recR 7063695 recR Escherichia coli O127:H6 str. E2348/69 recombination protein RecR YP_002327983.1 454882 D 574521 CDS YP_002327984.1 215485553 7063985 455597..457471 1 NC_011601.1 molecular chaperone; heat shock protein 90 457471 htpG 7063985 htpG Escherichia coli O127:H6 str. E2348/69 heat shock protein 90 YP_002327984.1 455597 D 574521 CDS YP_002327985.1 215485554 7062189 457652..458296 1 NC_011601.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 458296 adk 7062189 adk Escherichia coli O127:H6 str. E2348/69 adenylate kinase YP_002327985.1 457652 D 574521 CDS YP_002327986.1 215485555 7062411 458428..459390 1 NC_011601.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 459390 hemH 7062411 hemH Escherichia coli O127:H6 str. E2348/69 ferrochelatase YP_002327986.1 458428 D 574521 CDS YP_002327987.1 215485556 7064298 complement(459387..460346) 1 NC_011601.1 acetyl esterase 460346 aes 7064298 aes Escherichia coli O127:H6 str. E2348/69 acetyl esterase YP_002327987.1 459387 R 574521 CDS YP_002327988.1 215485557 7062415 460498..461802 1 NC_011601.1 inosine/guanosine kinase 461802 gsk 7062415 gsk Escherichia coli O127:H6 str. E2348/69 inosine/guanosine kinase YP_002327988.1 460498 D 574521 CDS YP_002327989.1 215485558 7064256 complement(461932..463608) 1 NC_011601.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein 463608 ybaL 7064256 ybaL Escherichia coli O127:H6 str. E2348/69 cation:proton antiport protein YP_002327989.1 461932 R 574521 CDS YP_002327990.1 215485559 7063699 complement(463847..465067) 1 NC_011601.1 fosmidomycin efflux system 465067 fsr 7063699 fsr Escherichia coli O127:H6 str. E2348/69 fosmidomycin efflux system YP_002327990.1 463847 R 574521 CDS YP_002327991.1 215485560 7061975 465285..466937 1 NC_011601.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 466937 ushA 7061975 ushA Escherichia coli O127:H6 str. E2348/69 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic YP_002327991.1 465285 D 574521 CDS YP_002327992.1 215485561 7062331 complement(466974..467453) 1 NC_011601.1 hypothetical protein 467453 ybaK 7062331 ybaK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327992.1 466974 R 574521 CDS YP_002327993.1 215485562 7062755 complement(467656..468450) 1 NC_011601.1 hypothetical protein 468450 ybaP 7062755 ybaP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327993.1 467656 R 574521 CDS YP_002327994.1 215485563 7063703 468596..468937 1 NC_011601.1 DNA-binding transcriptional regulator 468937 ybaQ 7063703 ybaQ Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002327994.1 468596 D 574521 CDS YP_002327995.1 215485564 7063704 complement(468995..471499) 1 NC_011601.1 copper exporting ATPase 471499 copA 7063704 copA Escherichia coli O127:H6 str. E2348/69 copper exporting ATPase YP_002327995.1 468995 R 574521 CDS YP_002327996.1 215485565 7062832 471762..472694 1 NC_011601.1 catalyzes the formation of glutamate from glutamine; glutaminase 472694 ybaS 7062832 ybaS Escherichia coli O127:H6 str. E2348/69 glutaminase YP_002327996.1 471762 D 574521 CDS YP_002327997.1 215485566 7063705 472697..473989 1 NC_011601.1 transporter 473989 ybaT 7063705 ybaT Escherichia coli O127:H6 str. E2348/69 transporter YP_002327997.1 472697 D 574521 CDS YP_002327998.1 215485567 7063706 474114..474521 1 NC_011601.1 activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 474521 cueR 7063706 cueR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator CueR YP_002327998.1 474114 D 574521 CDS YP_002327999.1 215485568 7063456 complement(475527..475949) 1 NC_011601.1 hypothetical protein 475949 7063456 E2348C_0424 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002327999.1 475527 R 574521 CDS YP_002328000.1 215485569 7063457 complement(476003..477019) 1 NC_011601.1 autotransporter adhesin, STEC autoagglutinating adhesin (Saa)-like protein 477019 7063457 E2348C_0425 Escherichia coli O127:H6 str. E2348/69 autotransporter adhesin, STEC autoagglutinating adhesin (Saa)-like protein YP_002328000.1 476003 R 574521 CDS YP_002328001.1 215485570 7063458 477387..477749 1 NC_011601.1 hypothetical protein 477749 7063458 E2348C_0426 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328001.1 477387 D 574521 CDS YP_002328002.1 215485571 7063459 complement(477852..478307) 1 NC_011601.1 hypothetical protein 478307 ybbJ 7063459 ybbJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328002.1 477852 R 574521 CDS YP_002328003.1 215485572 7063712 complement(478307..479224) 1 NC_011601.1 protease, membrane anchored 479224 ybbK 7063712 ybbK Escherichia coli O127:H6 str. E2348/69 protease, membrane anchored YP_002328003.1 478307 R 574521 CDS YP_002328004.1 215485573 7063713 479370..480047 1 NC_011601.1 ABC transporter ATP-binding protein 480047 ybbL 7063713 ybbL Escherichia coli O127:H6 str. E2348/69 ABC transporter ATP-binding protein YP_002328004.1 479370 D 574521 CDS YP_002328005.1 215485574 7063714 480034..480813 1 NC_011601.1 hypothetical protein 480813 ybbM 7063714 ybbM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328005.1 480034 D 574521 CDS YP_002328006.1 215485575 7063715 complement(480876..481730) 1 NC_011601.1 thioredoxin domain-containing protein 481730 ybbN 7063715 ybbN Escherichia coli O127:H6 str. E2348/69 thioredoxin domain-containing protein YP_002328006.1 480876 R 574521 CDS YP_002328007.1 215485576 7063716 complement(481791..482600) 1 NC_011601.1 short chain dehydrogenase 482600 ybbO 7063716 ybbO Escherichia coli O127:H6 str. E2348/69 short chain dehydrogenase YP_002328007.1 481791 R 574521 CDS YP_002328008.1 215485577 7063717 complement(482590..483216) 1 NC_011601.1 multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 483216 tesA 7063717 tesA Escherichia coli O127:H6 str. E2348/69 multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 YP_002328008.1 482590 R 574521 CDS YP_002328009.1 215485578 7061776 483184..483870 1 NC_011601.1 ABC transporter ATP-binding protein 483870 ybbA 7061776 ybbA Escherichia coli O127:H6 str. E2348/69 ABC transporter ATP-binding protein YP_002328009.1 483184 D 574521 CDS YP_002328010.1 215485579 7063710 483867..486281 1 NC_011601.1 hypothetical protein 486281 ybbP 7063710 ybbP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328010.1 483867 D 574521 CDS YP_002328011.1 215485580 7063718 486866..487912 1 NC_011601.1 transposase 487912 7063718 E2348C_0436 Escherichia coli O127:H6 str. E2348/69 transposase YP_002328011.1 486866 D 574521 CDS YP_002328012.1 215485581 7063460 complement(488095..489189) 1 NC_011601.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 489189 ybbB 7063460 ybbB Escherichia coli O127:H6 str. E2348/69 tRNA 2-selenouridine synthase YP_002328012.1 488095 R 574521 CDS YP_002328013.1 215485582 7063711 complement(489258..490184) 1 NC_011601.1 activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS 490184 allS 7063711 allS Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator AllS YP_002328013.1 489258 R 574521 CDS YP_002328014.1 215485583 7062444 490414..490896 1 NC_011601.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 490896 allA 7062444 allA Escherichia coli O127:H6 str. E2348/69 ureidoglycolate hydrolase YP_002328014.1 490414 D 574521 CDS YP_002328015.1 215485584 7062439 490974..491789 1 NC_011601.1 regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 491789 allR 7062439 allR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor AllR YP_002328015.1 490974 D 574521 CDS YP_002328016.1 215485585 7062443 491879..493660 1 NC_011601.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 493660 gcl 7062443 gcl Escherichia coli O127:H6 str. E2348/69 glyoxylate carboligase YP_002328016.1 491879 D 574521 CDS YP_002328017.1 215485586 7061640 493673..494449 1 NC_011601.1 hydroxypyruvate isomerase 494449 hyi 7061640 hyi Escherichia coli O127:H6 str. E2348/69 hydroxypyruvate isomerase YP_002328017.1 493673 D 574521 CDS YP_002328018.1 215485587 7062218 494549..495427 1 NC_011601.1 tartronate semialdehyde reductase, NADH-dependent 495427 glxR 7062218 glxR Escherichia coli O127:H6 str. E2348/69 tartronate semialdehyde reductase, NADH-dependent YP_002328018.1 494549 D 574521 CDS YP_002328019.1 215485588 7061719 495597..497051 1 NC_011601.1 allantoin permease 497051 ybbW 7061719 ybbW Escherichia coli O127:H6 str. E2348/69 allantoin permease YP_002328019.1 495597 D 574521 CDS YP_002328020.1 215485589 7063719 497111..498472 1 NC_011601.1 Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 498472 allB 7063719 allB Escherichia coli O127:H6 str. E2348/69 allantoinase YP_002328020.1 497111 D 574521 CDS YP_002328021.1 215485590 7062440 498528..499829 1 NC_011601.1 purine permease YbbY 499829 ybbY 7062440 ybbY Escherichia coli O127:H6 str. E2348/69 purine permease YbbY YP_002328021.1 498528 D 574521 CDS YP_002328022.1 215485591 7063720 499851..500996 1 NC_011601.1 glycerate kinase 500996 glxK 7063720 glxK Escherichia coli O127:H6 str. E2348/69 glycerate kinase YP_002328022.1 499851 D 574521 CDS YP_002328023.1 215485592 7061718 complement(501125..501910) 1 NC_011601.1 hypothetical protein 501910 ylbA 7061718 ylbA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328023.1 501125 R 574521 CDS YP_002328024.1 215485593 7062012 complement(501921..503156) 1 NC_011601.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 503156 allC 7062012 allC Escherichia coli O127:H6 str. E2348/69 allantoate amidohydrolase YP_002328024.1 501921 R 574521 CDS YP_002328025.1 215485594 7062441 complement(503178..504227) 1 NC_011601.1 ureidoglycolate dehydrogenase 504227 allD 7062441 allD Escherichia coli O127:H6 str. E2348/69 ureidoglycolate dehydrogenase YP_002328025.1 503178 R 574521 CDS YP_002328026.1 215485595 7062442 504544..506211 1 NC_011601.1 multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 506211 fdrA 7062442 fdrA Escherichia coli O127:H6 str. E2348/69 membrane protein FdrA YP_002328026.1 504544 D 574521 CDS YP_002328027.1 215485596 7062094 506221..507480 1 NC_011601.1 hypothetical protein 507480 ylbE 7062094 ylbE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328027.1 506221 D 574521 CDS YP_002328028.1 215485597 7062013 507491..508306 1 NC_011601.1 hypothetical protein 508306 ylbF 7062013 ylbF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328028.1 507491 D 574521 CDS YP_002328029.1 215485598 7062014 508303..509196 1 NC_011601.1 carbamate kinase 509196 ybcF 7062014 ybcF Escherichia coli O127:H6 str. E2348/69 carbamate kinase YP_002328029.1 508303 D 574521 CDS YP_002328030.1 215485599 7063721 complement(509429..510496) 1 NC_011601.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 510496 purK 7063721 purK Escherichia coli O127:H6 str. E2348/69 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_002328030.1 509429 R 574521 CDS YP_002328031.1 215485600 7063918 complement(510493..511002) 1 NC_011601.1 N5-carboxyaminoimidazole ribonucleotide mutase 511002 purE 7063918 purE Escherichia coli O127:H6 str. E2348/69 N5-carboxyaminoimidazole ribonucleotide mutase YP_002328031.1 510493 R 574521 CDS YP_002328032.1 215485601 7063915 complement(511120..511842) 1 NC_011601.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 511842 lpxH 7063915 lpxH Escherichia coli O127:H6 str. E2348/69 UDP-2,3-diacylglucosamine hydrolase YP_002328032.1 511120 R 574521 CDS YP_002328033.1 215485602 7061576 complement(511845..512339) 1 NC_011601.1 peptidyl-prolyl cis-trans isomerase B 512339 ppiB 7061576 ppiB Escherichia coli O127:H6 str. E2348/69 peptidyl-prolyl cis-trans isomerase B YP_002328033.1 511845 R 574521 CDS YP_002328034.1 215485603 7061271 512513..513898 1 NC_011601.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 513898 cysS 7061271 cysS Escherichia coli O127:H6 str. E2348/69 cysteinyl-tRNA synthetase YP_002328034.1 512513 D 574521 CDS YP_002328035.1 215485604 7065206 complement(513934..514455) 1 NC_011601.1 hypothetical protein 514455 ybcI 7065206 ybcI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328035.1 513934 R 574521 CDS YP_002328036.1 215485605 7063723 complement(514563..514775) 1 NC_011601.1 hypothetical protein 514775 ybcJ 7063723 ybcJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328036.1 514563 R 574521 CDS YP_002328037.1 215485606 7063724 complement(514777..515643) 1 NC_011601.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 515643 folD 7063724 folD Escherichia coli O127:H6 str. E2348/69 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_002328037.1 514777 R 574521 CDS YP_002328038.1 215485607 7063462 complement(517038..517694) 1 NC_011601.1 hypothetical protein 517694 7063462 E2348C_0465 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328038.1 517038 R 574521 CDS YP_002328039.1 215485608 7063463 complement(517938..518891) 1 NC_011601.1 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA; outer membrane protease 518891 ompT 7063463 ompT Escherichia coli O127:H6 str. E2348/69 outer membrane protease YP_002328039.1 517938 R 574521 CDS YP_002328040.1 215485609 7062879 complement(519549..520439) 1 NC_011601.1 hypothetical protein 520439 ybcH 7062879 ybcH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328040.1 519549 R 574521 CDS YP_002328041.1 215485610 7063722 complement(520440..523412) 1 NC_011601.1 bacteriophage N4 receptor, outer membrane subunit 523412 nfrA 7063722 nfrA Escherichia coli O127:H6 str. E2348/69 bacteriophage N4 receptor, outer membrane subunit YP_002328041.1 520440 R 574521 CDS YP_002328042.1 215485611 7065383 complement(523399..525636) 1 NC_011601.1 bacteriophage N4 adsorption protein B 525636 nfrB 7065383 nfrB Escherichia coli O127:H6 str. E2348/69 bacteriophage N4 adsorption protein B YP_002328042.1 523399 R 574521 CDS YP_002328043.1 215485612 7065384 complement(525786..527228) 1 NC_011601.1 sensor kinase CusS 527228 cusS 7065384 cusS Escherichia coli O127:H6 str. E2348/69 sensor kinase CusS YP_002328043.1 525786 R 574521 CDS YP_002328044.1 215485613 7065174 complement(527218..527901) 1 NC_011601.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR 527901 cusR 7065174 cusR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator CusR YP_002328044.1 527218 R 574521 CDS YP_002328045.1 215485614 7065173 528058..529440 1 NC_011601.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 529440 cusC 7065173 cusC Escherichia coli O127:H6 str. E2348/69 copper/silver efflux system outer membrane protein CusC YP_002328045.1 528058 D 574521 CDS YP_002328046.1 215485615 7065171 529464..529796 1 NC_011601.1 copper-binding protein 529796 cusF 7065171 cusF Escherichia coli O127:H6 str. E2348/69 copper-binding protein YP_002328046.1 529464 D 574521 CDS YP_002328047.1 215485616 7065172 529812..531035 1 NC_011601.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 531035 cusB 7065172 cusB Escherichia coli O127:H6 str. E2348/69 copper/silver efflux system membrane fusion protein CusB YP_002328047.1 529812 D 574521 CDS YP_002328048.1 215485617 7065170 531047..534190 1 NC_011601.1 copper/silver efflux system, membrane component 534190 cusA 7065170 cusA Escherichia coli O127:H6 str. E2348/69 copper/silver efflux system, membrane component YP_002328048.1 531047 D 574521 CDS YP_002328049.1 215485618 7065169 534292..535674 1 NC_011601.1 phenylalanine transporter 535674 pheP 7065169 pheP Escherichia coli O127:H6 str. E2348/69 phenylalanine transporter YP_002328049.1 534292 D 574521 CDS YP_002328050.1 215485619 7060723 complement(535832..537079) 1 NC_011601.1 mechanosensitive channel 537079 ybdG 7060723 ybdG Escherichia coli O127:H6 str. E2348/69 mechanosensitive channel YP_002328050.1 535832 R 574521 CDS YP_002328051.1 215485620 7063728 complement(537187..537840) 1 NC_011601.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 537840 nfsB 7063728 nfsB Escherichia coli O127:H6 str. E2348/69 dihydropteridine reductase YP_002328051.1 537187 R 574521 CDS YP_002328052.1 215485621 7065386 complement(537919..538302) 1 NC_011601.1 hypothetical protein 538302 ybdF 7065386 ybdF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328052.1 537919 R 574521 CDS YP_002328053.1 215485622 7063727 complement(538367..538615) 1 NC_011601.1 hypothetical protein 538615 ybdJ 7063727 ybdJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328053.1 538367 R 574521 CDS YP_002328054.1 215485623 7063730 complement(538681..539799) 1 NC_011601.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase 539799 ybdK 7063730 ybdK Escherichia coli O127:H6 str. E2348/69 carboxylate-amine ligase YP_002328054.1 538681 R 574521 CDS YP_002328055.1 215485624 7063731 540153..540404 1 NC_011601.1 regulatory protein MokC for HokC 2 540404 mokC2 7063731 mokC2 Escherichia coli O127:H6 str. E2348/69 regulatory protein MokC for HokC 2 YP_002328055.1 540153 D 574521 CDS YP_002328056.1 215485625 7063820 540252..540404 1 NC_011601.1 small toxic membrane peptide HokC 2 540404 hokC2 7063820 hokC2 Escherichia coli O127:H6 str. E2348/69 small toxic membrane peptide HokC 2 YP_002328056.1 540252 D 574521 CDS YP_002328057.1 215485626 7062170 complement(540526..541155) 1 NC_011601.1 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex 541155 entD 7062170 entD Escherichia coli O127:H6 str. E2348/69 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex YP_002328057.1 540526 R 574521 CDS YP_002328058.1 215485627 7063855 complement(541321..543561) 1 NC_011601.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 543561 fepA 7063855 fepA Escherichia coli O127:H6 str. E2348/69 outer membrane receptor FepA YP_002328058.1 541321 R 574521 CDS YP_002328059.1 215485628 7062100 543882..545006 1 NC_011601.1 enterobactin/ferric enterobactin esterase 545006 fes 7062100 fes Escherichia coli O127:H6 str. E2348/69 enterobactin/ferric enterobactin esterase YP_002328059.1 543882 D 574521 CDS YP_002328060.1 215485629 7062106 545009..545227 1 NC_011601.1 hypothetical protein 545227 ybdZ 7062106 ybdZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328060.1 545009 D 574521 CDS YP_002328061.1 215485630 7063736 545224..549105 1 NC_011601.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 549105 entF 7063736 entF Escherichia coli O127:H6 str. E2348/69 enterobactin synthase subunit F YP_002328061.1 545224 D 574521 CDS YP_002328062.1 215485631 7062104 complement(550451..551266) 1 NC_011601.1 with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein 551266 fepC 7062104 fepC Escherichia coli O127:H6 str. E2348/69 iron-enterobactin transporter ATP-binding protein YP_002328062.1 550451 R 574521 CDS YP_002328063.1 215485632 7062102 complement(551263..552255) 1 NC_011601.1 with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease 552255 fepG 7062102 fepG Escherichia coli O127:H6 str. E2348/69 iron-enterobactin transporter permease YP_002328063.1 551263 R 574521 CDS YP_002328064.1 215485633 7062105 complement(552252..553256) 1 NC_011601.1 with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein 553256 fepD 7062105 fepD Escherichia coli O127:H6 str. E2348/69 iron-enterobactin transporter membrane protein YP_002328064.1 552252 R 574521 CDS YP_002328065.1 215485634 7062103 553367..554617 1 NC_011601.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 554617 entS 7062103 entS Escherichia coli O127:H6 str. E2348/69 enterobactin exporter EntS YP_002328065.1 553367 D 574521 CDS YP_002328066.1 215485635 7063858 complement(554621..555577) 1 NC_011601.1 with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein 555577 fepB 7063858 fepB Escherichia coli O127:H6 str. E2348/69 iron-enterobactin transporter periplasmic binding protein YP_002328066.1 554621 R 574521 CDS YP_002328067.1 215485636 7062101 555766..556941 1 NC_011601.1 isochorismate synthase 1 556941 entC 7062101 entC Escherichia coli O127:H6 str. E2348/69 isochorismate synthase 1 YP_002328067.1 555766 D 574521 CDS YP_002328068.1 215485637 7063854 556951..558561 1 NC_011601.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 558561 entE 7063854 entE Escherichia coli O127:H6 str. E2348/69 enterobactin synthase subunit E YP_002328068.1 556951 D 574521 CDS YP_002328069.1 215485638 7063856 558575..559432 1 NC_011601.1 isochorismatase 559432 entB 7063856 entB Escherichia coli O127:H6 str. E2348/69 isochorismatase YP_002328069.1 558575 D 574521 CDS YP_002328070.1 215485639 7063853 559432..560178 1 NC_011601.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 560178 entA 7063853 entA Escherichia coli O127:H6 str. E2348/69 2,3-dihydroxybenzoate-2,3-dehydrogenase YP_002328070.1 559432 D 574521 CDS YP_002328071.1 215485640 7063852 560181..560594 1 NC_011601.1 hypothetical protein 560594 ybdB 7063852 ybdB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328071.1 560181 D 574521 CDS YP_002328072.1 215485641 7063725 560775..562880 1 NC_011601.1 carbon starvation protein 562880 cstA 7063725 cstA Escherichia coli O127:H6 str. E2348/69 carbon starvation protein YP_002328072.1 560775 D 574521 CDS YP_002328073.1 215485642 7065166 562993..563190 1 NC_011601.1 hypothetical protein 563190 ybdD 7065166 ybdD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328073.1 562993 D 574521 CDS YP_002328074.1 215485643 7063726 complement(563200..564288) 1 NC_011601.1 member of the iron-containing alcohol dehydrogenase; unknown function; hypothetical protein 564288 ybdH 7063726 ybdH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328074.1 563200 R 574521 CDS YP_002328075.1 215485644 7063729 564397..565557 1 NC_011601.1 catalyzes the transfer of an amino moiety; aminotransferase 565557 ybdL 7063729 ybdL Escherichia coli O127:H6 str. E2348/69 aminotransferase YP_002328075.1 564397 D 574521 CDS YP_002328076.1 215485645 7063732 complement(565558..566187) 1 NC_011601.1 hypothetical protein 566187 ybdM 7063732 ybdM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328076.1 565558 R 574521 CDS YP_002328077.1 215485646 7063733 complement(566160..567380) 1 NC_011601.1 hypothetical protein 567380 ybdN 7063733 ybdN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328077.1 566160 R 574521 CDS YP_002328078.1 215485647 7063734 complement(567527..568429) 1 NC_011601.1 DNA-binding transcriptional regulator 568429 ybdO 7063734 ybdO Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002328078.1 567527 R 574521 CDS YP_002328079.1 215485648 7063735 complement(568634..569380) 1 NC_011601.1 Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase 569380 dsbG 7063735 dsbG Escherichia coli O127:H6 str. E2348/69 disulfide isomerase/thiol-disulfide oxidase YP_002328079.1 568634 R 574521 CDS YP_002328080.1 215485649 7065065 569752..570315 1 NC_011601.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase 570315 ahpC 7065065 ahpC Escherichia coli O127:H6 str. E2348/69 alkyl hydroperoxide reductase YP_002328080.1 569752 D 574521 CDS YP_002328081.1 215485650 7062425 570486..572051 1 NC_011601.1 alkyl hydroperoxide reductase 572051 ahpF 7062425 ahpF Escherichia coli O127:H6 str. E2348/69 alkyl hydroperoxide reductase YP_002328081.1 570486 D 574521 CDS YP_002328082.1 215485651 7062426 complement(572172..572600) 1 NC_011601.1 universal stress protein UP12 572600 uspG 7062426 uspG Escherichia coli O127:H6 str. E2348/69 universal stress protein UP12 YP_002328082.1 572172 R 574521 CDS YP_002328083.1 215485652 7062338 complement(572954..573364) 1 NC_011601.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 573364 rnk 7062338 rnk Escherichia coli O127:H6 str. E2348/69 nucleoside diphosphate kinase regulator YP_002328083.1 572954 R 574521 CDS YP_002328084.1 215485653 7060855 complement(573594..574400) 1 NC_011601.1 ribonuclease I 574400 rna 7060855 rna Escherichia coli O127:H6 str. E2348/69 ribonuclease I YP_002328084.1 573594 R 574521 CDS YP_002328085.1 215485654 7060846 complement(574514..575977) 1 NC_011601.1 citrate: succinate antiporter 575977 citT 7060846 citT Escherichia coli O127:H6 str. E2348/69 citrate: succinate antiporter YP_002328085.1 574514 R 574521 CDS YP_002328086.1 215485655 7062804 complement(576028..576906) 1 NC_011601.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase 576906 citG 7062804 citG Escherichia coli O127:H6 str. E2348/69 triphosphoribosyl-dephospho-CoA synthase YP_002328086.1 576028 R 574521 CDS YP_002328087.1 215485656 7062803 complement(576881..577432) 1 NC_011601.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase 577432 citX 7062803 citX Escherichia coli O127:H6 str. E2348/69 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase YP_002328087.1 576881 R 574521 CDS YP_002328088.1 215485657 7062805 complement(577436..578968) 1 NC_011601.1 citrate lyase, citrate-ACP transferase (alpha) subunit 578968 citF 7062805 citF Escherichia coli O127:H6 str. E2348/69 citrate lyase, citrate-ACP transferase (alpha) subunit YP_002328088.1 577436 R 574521 CDS YP_002328089.1 215485658 7062802 complement(578979..579887) 1 NC_011601.1 citrate lyase, citryl-ACP lyase (beta) subunit 579887 citE 7062802 citE Escherichia coli O127:H6 str. E2348/69 citrate lyase, citryl-ACP lyase (beta) subunit YP_002328089.1 578979 R 574521 CDS YP_002328090.1 215485659 7062801 complement(579884..580180) 1 NC_011601.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 580180 citD 7062801 citD Escherichia coli O127:H6 str. E2348/69 citrate lyase subunit gamma YP_002328090.1 579884 R 574521 CDS YP_002328091.1 215485660 7062800 complement(580195..581253) 1 NC_011601.1 citrate lyase synthetase 581253 citC 7062800 citC Escherichia coli O127:H6 str. E2348/69 citrate lyase synthetase YP_002328091.1 580195 R 574521 CDS YP_002328092.1 215485661 7062799 581633..583291 1 NC_011601.1 sensory histidine kinase CitA in two-component regulatory system with CitB 583291 citA 7062799 citA Escherichia coli O127:H6 str. E2348/69 sensory histidine kinase CitA in two-component regulatory system with CitB YP_002328092.1 581633 D 574521 CDS YP_002328093.1 215485662 7062797 583260..583940 1 NC_011601.1 regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 583940 dpiA 7062797 dpiA Escherichia coli O127:H6 str. E2348/69 two-component response regulator DpiA YP_002328093.1 583260 D 574521 CDS YP_002328094.1 215485663 7062798 complement(583981..585366) 1 NC_011601.1 responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC 585366 dcuC 7062798 dcuC Escherichia coli O127:H6 str. E2348/69 C4-dicarboxylate transporter DcuC YP_002328094.1 583981 R 574521 CDS YP_002328095.1 215485664 7065233 585943..586503 1 NC_011601.1 catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 586503 pagP 7065233 pagP Escherichia coli O127:H6 str. E2348/69 palmitoyl transferase YP_002328095.1 585943 D 574521 CDS YP_002328096.1 215485665 7062904 586678..586887 1 NC_011601.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 586887 cspE 7062904 cspE Escherichia coli O127:H6 str. E2348/69 cold shock protein CspE YP_002328096.1 586678 D 574521 CDS YP_002328097.1 215485666 7062863 complement(586941..587324) 1 NC_011601.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 587324 crcB 7062863 crcB Escherichia coli O127:H6 str. E2348/69 camphor resistance protein CrcB YP_002328097.1 586941 R 574521 CDS YP_002328098.1 215485667 7062841 587417..588205 1 NC_011601.1 amidase 588205 ybeM 7062841 ybeM Escherichia coli O127:H6 str. E2348/69 amidase YP_002328098.1 587417 D 574521 CDS YP_002328099.1 215485668 7063742 588334..588537 1 NC_011601.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase E 588537 tatE 7063742 tatE Escherichia coli O127:H6 str. E2348/69 twin arginine translocase E YP_002328099.1 588334 D 574521 CDS YP_002328100.1 215485669 7061759 complement(588637..589602) 1 NC_011601.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 589602 lipA 7061759 lipA Escherichia coli O127:H6 str. E2348/69 lipoyl synthase YP_002328100.1 588637 R 574521 CDS YP_002328101.1 215485670 7063740 complement(590423..591064) 1 NC_011601.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 591064 lipB 7063740 lipB Escherichia coli O127:H6 str. E2348/69 lipoate-protein ligase B YP_002328101.1 590423 R 574521 CDS YP_002328102.1 215485671 7061543 complement(591165..591428) 1 NC_011601.1 hypothetical protein 591428 ybeD 7061543 ybeD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328102.1 591165 R 574521 CDS YP_002328103.1 215485672 7063739 complement(591538..592749) 1 NC_011601.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase 592749 dacA 7063739 dacA Escherichia coli O127:H6 str. E2348/69 D-alanyl-D-alanine carboxypeptidase YP_002328103.1 591538 R 574521 CDS YP_002328104.1 215485673 7065212 complement(592889..593977) 1 NC_011601.1 rare lipoprotein A 593977 rlpA 7065212 rlpA Escherichia coli O127:H6 str. E2348/69 rare lipoprotein A YP_002328104.1 592889 R 574521 CDS YP_002328105.1 215485674 7060836 complement(593988..595100) 1 NC_011601.1 cell wall shape-determining protein 595100 mrdB 7060836 mrdB Escherichia coli O127:H6 str. E2348/69 cell wall shape-determining protein YP_002328105.1 593988 R 574521 CDS YP_002328106.1 215485675 7060866 complement(595103..597004) 1 NC_011601.1 penicillin-binding protein 2 597004 mrdA 7060866 mrdA Escherichia coli O127:H6 str. E2348/69 penicillin-binding protein 2 YP_002328106.1 595103 R 574521 CDS YP_002328107.1 215485676 7060865 complement(597035..597502) 1 NC_011601.1 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 597502 ybeA 7060865 ybeA Escherichia coli O127:H6 str. E2348/69 rRNA large subunit methyltransferase YP_002328107.1 597035 R 574521 CDS YP_002328108.1 215485677 7063737 complement(597506..597823) 1 NC_011601.1 hypothetical protein 597823 ybeB 7063737 ybeB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328108.1 597506 R 574521 CDS YP_002328109.1 215485678 7063738 complement(598083..598694) 1 NC_011601.1 alpha-ribazole-5'-phosphate phosphatase 598694 cobC 7063738 cobC Escherichia coli O127:H6 str. E2348/69 alpha-ribazole-5'-phosphate phosphatase YP_002328109.1 598083 R 574521 CDS YP_002328110.1 215485679 7062825 complement(598718..599359) 1 NC_011601.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 599359 nadD 7062825 nadD Escherichia coli O127:H6 str. E2348/69 nicotinic acid mononucleotide adenylyltransferase YP_002328110.1 598718 R 574521 CDS YP_002328111.1 215485680 7060907 complement(599361..600392) 1 NC_011601.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 600392 holA 7060907 holA Escherichia coli O127:H6 str. E2348/69 DNA polymerase III subunit delta YP_002328111.1 599361 R 574521 CDS YP_002328112.1 215485681 7062171 complement(600392..600973) 1 NC_011601.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 600973 rlpB 7062171 rlpB Escherichia coli O127:H6 str. E2348/69 LPS-assembly lipoprotein RlpB YP_002328112.1 600392 R 574521 CDS YP_002328113.1 215485682 7060837 complement(600988..603570) 1 NC_011601.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 603570 leuS 7060837 leuS Escherichia coli O127:H6 str. E2348/69 leucyl-tRNA synthetase YP_002328113.1 600988 R 574521 CDS YP_002328114.1 215485683 7061530 603805..604287 1 NC_011601.1 hypothetical protein 604287 ybeL 7061530 ybeL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328114.1 603805 D 574521 CDS YP_002328115.1 215485684 7063741 complement(604332..605267) 1 NC_011601.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 605267 rihA 7063741 rihA Escherichia coli O127:H6 str. E2348/69 ribonucleoside hydrolase 1 YP_002328115.1 604332 R 574521 CDS YP_002328116.1 215485685 7060824 complement(605385..606110) 1 NC_011601.1 glutamate and aspartate transporter subunit 606110 gltL 7060824 gltL Escherichia coli O127:H6 str. E2348/69 glutamate and aspartate transporter subunit YP_002328116.1 605385 R 574521 CDS YP_002328117.1 215485686 7061710 complement(606110..606784) 1 NC_011601.1 glutamate/aspartate transport system permease GltK; membrane component of ABC superfamily 606784 gltK 7061710 gltK Escherichia coli O127:H6 str. E2348/69 glutamate/aspartate transport system permease GltK; membrane component of ABC superfamily YP_002328117.1 606110 R 574521 CDS YP_002328118.1 215485687 7061709 complement(606784..607524) 1 NC_011601.1 glutamate/aspartate transport system permease GltJ; membrane component of ABC superfamily 607524 gltJ 7061709 gltJ Escherichia coli O127:H6 str. E2348/69 glutamate/aspartate transport system permease GltJ; membrane component of ABC superfamily YP_002328118.1 606784 R 574521 CDS YP_002328119.1 215485688 7062756 complement(607694..608602) 1 NC_011601.1 glutamate and aspartate transporter subunit 608602 gltI 7062756 gltI Escherichia coli O127:H6 str. E2348/69 glutamate and aspartate transporter subunit YP_002328119.1 607694 R 574521 CDS YP_002328120.1 215485689 7061707 609056..610933 1 NC_011601.1 hypothetical protein 610933 7061707 E2348C_0549 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328120.1 609056 D 574521 CDS YP_002328121.1 215485690 7063464 complement(611066..612607) 1 NC_011601.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 612607 lnt 7063464 lnt Escherichia coli O127:H6 str. E2348/69 apolipoprotein N-acyltransferase YP_002328121.1 611066 R 574521 CDS YP_002328122.1 215485691 7061553 complement(612632..613510) 1 NC_011601.1 ion transport 613510 ybeX 7061553 ybeX Escherichia coli O127:H6 str. E2348/69 ion transport YP_002328122.1 612632 R 574521 CDS YP_002328123.1 215485692 7063743 complement(613600..614067) 1 NC_011601.1 metalloprotease 614067 ybeY 7063743 ybeY Escherichia coli O127:H6 str. E2348/69 metalloprotease YP_002328123.1 613600 R 574521 CDS YP_002328124.1 215485693 7063744 complement(614064..615143) 1 NC_011601.1 hypothetical protein 615143 ybeZ 7063744 ybeZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328124.1 614064 R 574521 CDS YP_002328125.1 215485694 7063745 complement(615257..616681) 1 NC_011601.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 616681 miaB 7063745 miaB Escherichia coli O127:H6 str. E2348/69 (dimethylallyl)adenosine tRNA methylthiotransferase YP_002328125.1 615257 R 574521 CDS YP_002328126.1 215485695 7063784 616827..618002 1 NC_011601.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 618002 ubiF 7063784 ubiF Escherichia coli O127:H6 str. E2348/69 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_002328126.1 616827 D 574521 CDS YP_002328127.1 215485696 7063770 complement(619130..620794) 1 NC_011601.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 620794 asnB 7063770 asnB Escherichia coli O127:H6 str. E2348/69 asparagine synthetase B YP_002328127.1 619130 R 574521 CDS YP_002328128.1 215485697 7061412 complement(621051..621803) 1 NC_011601.1 UMP phosphatase 621803 nagD 7061412 nagD Escherichia coli O127:H6 str. E2348/69 UMP phosphatase YP_002328128.1 621051 R 574521 CDS YP_002328129.1 215485698 7060914 complement(621851..623071) 1 NC_011601.1 DNA-binding transcriptional dual regulator, repressor of the N-acetylglucosamine operon 623071 nagC 7060914 nagC Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional dual regulator, repressor of the N-acetylglucosamine operon YP_002328129.1 621851 R 574521 CDS YP_002328130.1 215485699 7060913 complement(623080..624228) 1 NC_011601.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 624228 nagA 7060913 nagA Escherichia coli O127:H6 str. E2348/69 N-acetylglucosamine-6-phosphate deacetylase YP_002328130.1 623080 R 574521 CDS YP_002328131.1 215485700 7060911 complement(624288..625088) 1 NC_011601.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 625088 nagB 7060911 nagB Escherichia coli O127:H6 str. E2348/69 glucosamine-6-phosphate deaminase YP_002328131.1 624288 R 574521 CDS YP_002328132.1 215485701 7060912 625421..627367 1 NC_011601.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunit IIABC 627367 nagE 7060912 nagE Escherichia coli O127:H6 str. E2348/69 PTS system N-acetyl glucosamine specific transporter subunit IIABC YP_002328132.1 625421 D 574521 CDS YP_002328133.1 215485702 7060915 complement(627456..628736) 1 NC_011601.1 hypothetical protein 628736 7060915 E2348C_0562 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328133.1 627456 R 574521 CDS YP_002328134.1 215485703 7063465 complement(628750..629220) 1 NC_011601.1 hypothetical protein 629220 7063465 E2348C_0563 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328134.1 628750 R 574521 CDS YP_002328135.1 215485704 7063466 complement(629217..630386) 1 NC_011601.1 hypothetical protein 630386 7063466 E2348C_0564 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328135.1 629217 R 574521 CDS YP_002328136.1 215485705 7063467 complement(630422..631180) 1 NC_011601.1 TerC family integral membrane protein 631180 7063467 E2348C_0565 Escherichia coli O127:H6 str. E2348/69 TerC family integral membrane protein YP_002328136.1 630422 R 574521 CDS YP_002328137.1 215485706 7063468 complement(631240..632127) 1 NC_011601.1 dihydrodipicolinate synthase 632127 7063468 E2348C_0566 Escherichia coli O127:H6 str. E2348/69 dihydrodipicolinate synthase YP_002328137.1 631240 R 574521 CDS YP_002328138.1 215485707 7063469 complement(632131..633288) 1 NC_011601.1 alcohol dehydrogenase 633288 7063469 E2348C_0567 Escherichia coli O127:H6 str. E2348/69 alcohol dehydrogenase YP_002328138.1 632131 R 574521 CDS YP_002328139.1 215485708 7063470 633458..634693 1 NC_011601.1 hypothetical protein 634693 7063470 E2348C_0568 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328139.1 633458 D 574521 CDS YP_002328140.1 215485709 7063471 634686..635672 1 NC_011601.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 635672 pdxA 7063471 pdxA Escherichia coli O127:H6 str. E2348/69 4-hydroxythreonine-4-phosphate dehydrogenase YP_002328140.1 634686 D 574521 CDS YP_002328141.1 215485710 7063472 635674..636435 1 NC_011601.1 DeoR family transcriptional regulator 636435 7063472 E2348C_0570 Escherichia coli O127:H6 str. E2348/69 DeoR family transcriptional regulator YP_002328141.1 635674 D 574521 CDS YP_002328142.1 215485711 7063473 636655..638319 1 NC_011601.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 638319 glnS 7063473 glnS Escherichia coli O127:H6 str. E2348/69 glutaminyl-tRNA synthetase YP_002328142.1 636655 D 574521 CDS YP_002328143.1 215485712 7061686 638761..640167 1 NC_011601.1 outer membrane porin 640167 ybfM 7061686 ybfM Escherichia coli O127:H6 str. E2348/69 outer membrane porin YP_002328143.1 638761 D 574521 CDS YP_002328144.1 215485713 7063264 640217..640543 1 NC_011601.1 lipoprotein 640543 ybfN 7063264 ybfN Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002328144.1 640217 D 574521 CDS YP_002328145.1 215485714 7063265 complement(640627..641073) 1 NC_011601.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 641073 fur 7063265 fur Escherichia coli O127:H6 str. E2348/69 ferric uptake regulator YP_002328145.1 640627 R 574521 CDS YP_002328146.1 215485715 7061603 complement(641066..641152) 1 NC_011601.1 ryhB-regulated fur leader peptide 641152 uof 7061603 uof Escherichia coli O127:H6 str. E2348/69 ryhB-regulated fur leader peptide YP_002328146.1 641066 R 574521 CDS YP_002328147.1 215485716 7062327 complement(641362..641892) 1 NC_011601.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 641892 fldA 7062327 fldA Escherichia coli O127:H6 str. E2348/69 flavodoxin FldA YP_002328147.1 641362 R 574521 CDS YP_002328148.1 215485717 7062136 complement(642032..642325) 1 NC_011601.1 LexA regulated protein 642325 ybfE 7062136 ybfE Escherichia coli O127:H6 str. E2348/69 LexA regulated protein YP_002328148.1 642032 R 574521 CDS YP_002328149.1 215485718 7063747 complement(642465..643229) 1 NC_011601.1 hypothetical protein 643229 ybfF 7063747 ybfF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328149.1 642465 R 574521 CDS YP_002328150.1 215485719 7063183 643414..643959 1 NC_011601.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 643959 seqA 7063183 seqA Escherichia coli O127:H6 str. E2348/69 replication initiation regulator SeqA YP_002328150.1 643414 D 574521 CDS YP_002328151.1 215485720 7065365 643985..645625 1 NC_011601.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 645625 pgm 7065365 pgm Escherichia coli O127:H6 str. E2348/69 phosphoglucomutase YP_002328151.1 643985 D 574521 CDS YP_002328152.1 215485721 7060716 complement(645682..647001) 1 NC_011601.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 647001 potE 7060716 potE Escherichia coli O127:H6 str. E2348/69 putrescine transporter YP_002328152.1 645682 R 574521 CDS YP_002328153.1 215485722 7060774 complement(646998..649196) 1 NC_011601.1 ornithine decarboxylase 649196 speF 7060774 speF Escherichia coli O127:H6 str. E2348/69 ornithine decarboxylase YP_002328153.1 646998 R 574521 CDS YP_002328154.1 215485723 7062745 complement(649792..650469) 1 NC_011601.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE 650469 kdpE 7062745 kdpE Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator KdpE YP_002328154.1 649792 R 574521 CDS YP_002328155.1 215485724 7063576 complement(650466..653150) 1 NC_011601.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD 653150 kdpD 7063576 kdpD Escherichia coli O127:H6 str. E2348/69 sensor protein KdpD YP_002328155.1 650466 R 574521 CDS YP_002328156.1 215485725 7063575 complement(653143..653715) 1 NC_011601.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 653715 kdpC 7063575 kdpC Escherichia coli O127:H6 str. E2348/69 potassium-transporting ATPase subunit C YP_002328156.1 653143 R 574521 CDS YP_002328157.1 215485726 7063574 complement(653724..655772) 1 NC_011601.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 655772 kdpB 7063574 kdpB Escherichia coli O127:H6 str. E2348/69 potassium-transporting ATPase subunit B YP_002328157.1 653724 R 574521 CDS YP_002328158.1 215485727 7063573 complement(655795..657468) 1 NC_011601.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 657468 kdpA 7063573 kdpA Escherichia coli O127:H6 str. E2348/69 potassium-transporting ATPase subunit A YP_002328158.1 655795 R 574521 CDS YP_002328159.1 215485728 7063572 complement(657468..657557) 1 NC_011601.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit F 657557 kdpF 7063572 kdpF Escherichia coli O127:H6 str. E2348/69 potassium-transporting ATPase subunit F YP_002328159.1 657468 R 574521 CDS YP_002328160.1 215485729 7063577 657870..658076 1 NC_011601.1 hypothetical protein 658076 ybfA 7063577 ybfA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328160.1 657870 D 574521 CDS YP_002328161.1 215485730 7063746 658177..658686 1 NC_011601.1 hypothetical protein 658686 ybgA 7063746 ybgA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328161.1 658177 D 574521 CDS YP_002328162.1 215485731 7063266 658683..660101 1 NC_011601.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 660101 phr 7063266 phr Escherichia coli O127:H6 str. E2348/69 deoxyribodipyrimidine photolyase YP_002328162.1 658683 D 574521 CDS YP_002328163.1 215485732 7060751 complement(660143..661624) 1 NC_011601.1 transporter 661624 ybgH 7060751 ybgH Escherichia coli O127:H6 str. E2348/69 transporter YP_002328163.1 660143 R 574521 CDS YP_002328164.1 215485733 7063270 661895..662638 1 NC_011601.1 hydrolase-oxidase 662638 ybgI 7063270 ybgI Escherichia coli O127:H6 str. E2348/69 hydrolase-oxidase YP_002328164.1 661895 D 574521 CDS YP_002328165.1 215485734 7063271 662661..663317 1 NC_011601.1 carboxylase subunit 663317 ybgJ 7063271 ybgJ Escherichia coli O127:H6 str. E2348/69 carboxylase subunit YP_002328165.1 662661 D 574521 CDS YP_002328166.1 215485735 7063272 663311..664243 1 NC_011601.1 carboxylase subunit 664243 ybgK 7063272 ybgK Escherichia coli O127:H6 str. E2348/69 carboxylase subunit YP_002328166.1 663311 D 574521 CDS YP_002328167.1 215485736 7063273 664233..664967 1 NC_011601.1 LamB/YcsF family protein 664967 ybgL 7063273 ybgL Escherichia coli O127:H6 str. E2348/69 LamB/YcsF family protein YP_002328167.1 664233 D 574521 CDS YP_002328168.1 215485737 7063274 665003..665794 1 NC_011601.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 665794 nei 7063274 nei Escherichia coli O127:H6 str. E2348/69 endonuclease VIII YP_002328168.1 665003 D 574521 CDS YP_002328169.1 215485738 7065378 complement(665791..666837) 1 NC_011601.1 regulator 666837 abrB 7065378 abrB Escherichia coli O127:H6 str. E2348/69 regulator YP_002328169.1 665791 R 574521 CDS YP_002328170.1 215485739 7063275 complement(667511..668794) 1 NC_011601.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 668794 gltA 7063275 gltA Escherichia coli O127:H6 str. E2348/69 type II citrate synthase YP_002328170.1 667511 R 574521 CDS YP_002328171.1 215485740 7061704 669503..669892 1 NC_011601.1 succinate dehydrogenase cytochrome b556 large membrane subunit 669892 sdhC 7061704 sdhC Escherichia coli O127:H6 str. E2348/69 succinate dehydrogenase cytochrome b556 large membrane subunit YP_002328171.1 669503 D 574521 CDS YP_002328172.1 215485741 7065349 669886..670233 1 NC_011601.1 succinate dehydrogenase cytochrome b556 small membrane subunit 670233 sdhD 7065349 sdhD Escherichia coli O127:H6 str. E2348/69 succinate dehydrogenase cytochrome b556 small membrane subunit YP_002328172.1 669886 D 574521 CDS YP_002328173.1 215485742 7065350 670233..671999 1 NC_011601.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 671999 sdhA 7065350 sdhA Escherichia coli O127:H6 str. E2348/69 succinate dehydrogenase flavoprotein subunit YP_002328173.1 670233 D 574521 CDS YP_002328174.1 215485743 7065347 672015..672731 1 NC_011601.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 672731 sdhB 7065347 sdhB Escherichia coli O127:H6 str. E2348/69 succinate dehydrogenase iron-sulfur subunit YP_002328174.1 672015 D 574521 CDS YP_002328175.1 215485744 7065348 673043..675844 1 NC_011601.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 675844 sucA 7065348 sucA Escherichia coli O127:H6 str. E2348/69 2-oxoglutarate dehydrogenase E1 YP_002328175.1 673043 D 574521 CDS YP_002328176.1 215485745 7062777 675859..677076 1 NC_011601.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 677076 sucB 7062777 sucB Escherichia coli O127:H6 str. E2348/69 dihydrolipoamide succinyltransferase YP_002328176.1 675859 D 574521 CDS YP_002328177.1 215485746 7062778 677170..678336 1 NC_011601.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 678336 sucC 7062778 sucC Escherichia coli O127:H6 str. E2348/69 succinyl-CoA synthetase subunit beta YP_002328177.1 677170 D 574521 CDS YP_002328178.1 215485747 7062779 678336..679205 1 NC_011601.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 679205 sucD 7062779 sucD Escherichia coli O127:H6 str. E2348/69 succinyl-CoA synthetase subunit alpha YP_002328178.1 678336 D 574521 CDS YP_002328179.1 215485748 7062780 complement(679309..680031) 1 NC_011601.1 regulates the succiny-lCoA synthetase operon; DNA-binding transcriptional repressor MngR 680031 mngR 7062780 mngR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor MngR YP_002328179.1 679309 R 574521 CDS YP_002328180.1 215485749 7064965 680697..682070 1 NC_011601.1 transposase of ISEc13 682070 7064965 E2348C_0611 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002328180.1 680697 D 574521 CDS YP_002328181.1 215485750 7063474 complement(682142..682591) 1 NC_011601.1 converts methylaspartate to L-glutamate; methylaspartate mutase subunit S 682591 7063474 E2348C_0612 Escherichia coli O127:H6 str. E2348/69 methylaspartate mutase subunit S YP_002328181.1 682142 R 574521 CDS YP_002328182.1 215485751 7063475 complement(682778..682945) 1 NC_011601.1 hypothetical protein 682945 7063475 E2348C_0613 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328182.1 682778 R 574521 CDS YP_002328183.1 215485752 7063476 complement(683138..683560) 1 NC_011601.1 hypothetical protein 683560 7063476 E2348C_0614 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328183.1 683138 R 574521 CDS YP_002328184.1 215485753 7063477 complement(683641..684585) 1 NC_011601.1 hypothetical protein 684585 7063477 E2348C_0615 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328184.1 683641 R 574521 CDS YP_002328185.1 215485754 7063478 685391..686959 1 NC_011601.1 cytochrome d terminal oxidase, subunit I 686959 cydA 7063478 cydA Escherichia coli O127:H6 str. E2348/69 cytochrome d terminal oxidase, subunit I YP_002328185.1 685391 D 574521 CDS YP_002328186.1 215485755 7065184 686975..688114 1 NC_011601.1 cytochrome d terminal oxidase, subunit II 688114 cydB 7065184 cydB Escherichia coli O127:H6 str. E2348/69 cytochrome d terminal oxidase, subunit II YP_002328186.1 686975 D 574521 CDS YP_002328187.1 215485756 7065185 688129..688242 1 NC_011601.1 hypothetical protein 688242 ybgT 7065185 ybgT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328187.1 688129 D 574521 CDS YP_002328188.1 215485757 7063277 688242..688535 1 NC_011601.1 hypothetical protein 688535 ybgE 7063277 ybgE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328188.1 688242 D 574521 CDS YP_002328189.1 215485758 7063268 688685..689089 1 NC_011601.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase 689089 ybgC 7063268 ybgC Escherichia coli O127:H6 str. E2348/69 acyl-CoA thioester hydrolase YP_002328189.1 688685 D 574521 CDS YP_002328190.1 215485759 7063267 689086..689778 1 NC_011601.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 689778 tolQ 7063267 tolQ Escherichia coli O127:H6 str. E2348/69 colicin uptake protein TolQ YP_002328190.1 689086 D 574521 CDS YP_002328191.1 215485760 7061815 689782..690210 1 NC_011601.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 690210 tolR 7061815 tolR Escherichia coli O127:H6 str. E2348/69 colicin uptake protein TolR YP_002328191.1 689782 D 574521 CDS YP_002328192.1 215485761 7061816 690275..691477 1 NC_011601.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 691477 tolA 7061816 tolA Escherichia coli O127:H6 str. E2348/69 cell envelope integrity inner membrane protein TolA YP_002328192.1 690275 D 574521 CDS YP_002328193.1 215485762 7061812 691610..692902 1 NC_011601.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 692902 tolB 7061812 tolB Escherichia coli O127:H6 str. E2348/69 translocation protein TolB YP_002328193.1 691610 D 574521 CDS YP_002328194.1 215485763 7061813 692937..693458 1 NC_011601.1 peptidoglycan-associated outer membrane lipoprotein 693458 pal 7061813 pal Escherichia coli O127:H6 str. E2348/69 peptidoglycan-associated outer membrane lipoprotein YP_002328194.1 692937 D 574521 CDS YP_002328195.1 215485764 7062905 693468..694259 1 NC_011601.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 694259 ybgF 7062905 ybgF Escherichia coli O127:H6 str. E2348/69 tol-pal system protein YbgF YP_002328195.1 693468 D 574521 CDS YP_002328196.1 215485765 7065254 695669..696712 1 NC_011601.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 696712 nadA 7065254 nadA Escherichia coli O127:H6 str. E2348/69 quinolinate synthetase YP_002328196.1 695669 D 574521 CDS YP_002328197.1 215485766 7060904 696750..697469 1 NC_011601.1 nicotinamide mononucleotide transporter 697469 pnuC 7060904 pnuC Escherichia coli O127:H6 str. E2348/69 nicotinamide mononucleotide transporter YP_002328197.1 696750 D 574521 CDS YP_002328198.1 215485767 7060766 complement(697466..698407) 1 NC_011601.1 involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB 698407 zitB 7060766 zitB Escherichia coli O127:H6 str. E2348/69 zinc transporter ZitB YP_002328198.1 697466 R 574521 CDS YP_002328199.1 215485768 7063260 complement(698521..698901) 1 NC_011601.1 hypothetical protein 698901 ybgS 7063260 ybgS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328199.1 698521 R 574521 CDS YP_002328200.1 215485769 7063276 699217..700269 1 NC_011601.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 700269 aroG 7063276 aroG Escherichia coli O127:H6 str. E2348/69 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002328200.1 699217 D 574521 CDS YP_002328201.1 215485770 7061395 complement(700435..701187) 1 NC_011601.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 701187 gpmA 7061395 gpmA Escherichia coli O127:H6 str. E2348/69 phosphoglyceromutase YP_002328201.1 700435 R 574521 CDS YP_002328202.1 215485771 7064234 complement(701390..702430) 1 NC_011601.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 702430 galM 7064234 galM Escherichia coli O127:H6 str. E2348/69 aldose 1-epimerase YP_002328202.1 701390 R 574521 CDS YP_002328203.1 215485772 7061619 complement(702424..703572) 1 NC_011601.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 703572 galK 7061619 galK Escherichia coli O127:H6 str. E2348/69 galactokinase YP_002328203.1 702424 R 574521 CDS YP_002328204.1 215485773 7061618 complement(703576..704622) 1 NC_011601.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 704622 galT 7061618 galT Escherichia coli O127:H6 str. E2348/69 galactose-1-phosphate uridylyltransferase YP_002328204.1 703576 R 574521 CDS YP_002328205.1 215485774 7061623 complement(704632..705648) 1 NC_011601.1 UDP-galactose-4-epimerase 705648 7061623 E2348C_0636 Escherichia coli O127:H6 str. E2348/69 UDP-galactose-4-epimerase YP_002328205.1 704632 R 574521 CDS YP_002328206.1 215485775 7063479 complement(705898..707370) 1 NC_011601.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF 707370 modF 7063479 modF Escherichia coli O127:H6 str. E2348/69 molybdenum transport ATP-binding protein ModF YP_002328206.1 705898 R 574521 CDS YP_002328207.1 215485776 7063816 complement(707438..708226) 1 NC_011601.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE 708226 modE 7063816 modE Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator ModE YP_002328207.1 707438 R 574521 CDS YP_002328208.1 215485777 7063815 708355..708504 1 NC_011601.1 hypothetical protein 708504 ybhT 7063815 ybhT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328208.1 708355 D 574521 CDS YP_002328209.1 215485778 7063296 708671..709444 1 NC_011601.1 with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 709444 modA 7063296 modA Escherichia coli O127:H6 str. E2348/69 molybdate transporter periplasmic protein YP_002328209.1 708671 D 574521 CDS YP_002328210.1 215485779 7063812 709444..710133 1 NC_011601.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 710133 modB 7063812 modB Escherichia coli O127:H6 str. E2348/69 molybdate ABC transporter permease YP_002328210.1 709444 D 574521 CDS YP_002328211.1 215485780 7063813 710136..711194 1 NC_011601.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 711194 modC 7063813 modC Escherichia coli O127:H6 str. E2348/69 molybdate transporter ATP-binding protein YP_002328211.1 710136 D 574521 CDS YP_002328212.1 215485781 7063814 complement(711195..712013) 1 NC_011601.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase 712013 ybhA 7063814 ybhA Escherichia coli O127:H6 str. E2348/69 phosphotransferase YP_002328212.1 711195 R 574521 CDS YP_002328213.1 215485782 7063278 712168..713163 1 NC_011601.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 713163 pgl 7063278 pgl Escherichia coli O127:H6 str. E2348/69 6-phosphogluconolactonase YP_002328213.1 712168 D 574521 CDS YP_002328214.1 215485783 7060715 complement(713204..714157) 1 NC_011601.1 DNA-binding transcriptional regulator 714157 ybhD 7060715 ybhD Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002328214.1 713204 R 574521 CDS YP_002328215.1 215485784 7063281 714341..715393 1 NC_011601.1 hypothetical protein 715393 ybhH 7063281 ybhH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328215.1 714341 D 574521 CDS YP_002328216.1 215485785 7063284 715469..716812 1 NC_011601.1 transporter 716812 ybhI 7063284 ybhI Escherichia coli O127:H6 str. E2348/69 transporter YP_002328216.1 715469 D 574521 CDS YP_002328217.1 215485786 7063285 717072..719333 1 NC_011601.1 hypothetical protein 719333 ybhJ 7063285 ybhJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328217.1 717072 D 574521 CDS YP_002328218.1 215485787 7063286 complement(719473..720756) 1 NC_011601.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase; pectinesterase 720756 ybhC 7063286 ybhC Escherichia coli O127:H6 str. E2348/69 pectinesterase YP_002328218.1 719473 R 574521 CDS YP_002328219.1 215485788 7061166 complement(720891..721961) 1 NC_011601.1 integrase 721961 7061166 E2348C_0650 Escherichia coli O127:H6 str. E2348/69 integrase YP_002328219.1 720891 R 574521 CDS YP_002328220.1 215485789 7063480 complement(721939..722157) 1 NC_011601.1 excisionase 722157 7063480 E2348C_0651 Escherichia coli O127:H6 str. E2348/69 excisionase YP_002328220.1 721939 R 574521 CDS YP_002328221.1 215485790 7063481 complement(722197..722364) 1 NC_011601.1 hypothetical protein 722364 7063481 E2348C_0652 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328221.1 722197 R 574521 CDS YP_002328222.1 215485791 7063482 complement(722437..722721) 1 NC_011601.1 hypothetical protein 722721 7063482 E2348C_0653 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328222.1 722437 R 574521 CDS YP_002328223.1 215485792 7063483 complement(722714..723346) 1 NC_011601.1 hypothetical protein 723346 7063483 E2348C_0654 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328223.1 722714 R 574521 CDS YP_002328224.1 215485793 7063484 complement(723357..723554) 1 NC_011601.1 hypothetical protein 723554 7063484 E2348C_0655 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328224.1 723357 R 574521 CDS YP_002328225.1 215485794 7063485 complement(723556..723951) 1 NC_011601.1 hypothetical protein 723951 7063485 E2348C_0656 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328225.1 723556 R 574521 CDS YP_002328226.1 215485795 7063486 complement(723970..724101) 1 NC_011601.1 hypothetical protein 724101 7063486 E2348C_0657 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328226.1 723970 R 574521 CDS YP_002328227.1 215485796 7063487 complement(724147..724785) 1 NC_011601.1 hypothetical protein 724785 7063487 E2348C_0658 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328227.1 724147 R 574521 CDS YP_002328228.1 215485797 7063488 complement(724772..725041) 1 NC_011601.1 hypothetical protein 725041 7063488 E2348C_0659 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328228.1 724772 R 574521 CDS YP_002328229.1 215485798 7063489 complement(725038..725205) 1 NC_011601.1 hypothetical protein 725205 7063489 E2348C_0660 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328229.1 725038 R 574521 CDS YP_002328230.1 215485799 7063490 complement(725216..725512) 1 NC_011601.1 anti-RecBCD protein 725512 7063490 E2348C_0661 Escherichia coli O127:H6 str. E2348/69 anti-RecBCD protein YP_002328230.1 725216 R 574521 CDS YP_002328231.1 215485800 7063491 complement(725526..726032) 1 NC_011601.1 single-stranded DNA-binding protein 726032 7063491 E2348C_0662 Escherichia coli O127:H6 str. E2348/69 single-stranded DNA-binding protein YP_002328231.1 725526 R 574521 CDS YP_002328232.1 215485801 7063492 complement(726029..726496) 1 NC_011601.1 hypothetical protein 726496 7063492 E2348C_0663 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328232.1 726029 R 574521 CDS YP_002328233.1 215485802 7063493 complement(726497..727204) 1 NC_011601.1 recombination protein 727204 7063493 E2348C_0664 Escherichia coli O127:H6 str. E2348/69 recombination protein YP_002328233.1 726497 R 574521 CDS YP_002328234.1 215485803 7063494 complement(727213..727383) 1 NC_011601.1 hypothetical protein 727383 7063494 E2348C_0665 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328234.1 727213 R 574521 CDS YP_002328235.1 215485804 7063495 complement(727459..727704) 1 NC_011601.1 hypothetical protein 727704 7063495 E2348C_0666 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328235.1 727459 R 574521 CDS YP_002328236.1 215485805 7063496 complement(727705..728073) 1 NC_011601.1 single-stranded DNA-binding protein 728073 7063496 E2348C_0667 Escherichia coli O127:H6 str. E2348/69 single-stranded DNA-binding protein YP_002328236.1 727705 R 574521 CDS YP_002328237.1 215485806 7063497 complement(728253..728576) 1 NC_011601.1 hypothetical protein 728576 7063497 E2348C_0668 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328237.1 728253 R 574521 CDS YP_002328238.1 215485807 7063498 complement(728639..728863) 1 NC_011601.1 hypothetical protein 728863 7063498 E2348C_0669 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328238.1 728639 R 574521 CDS YP_002328239.1 215485808 7063499 complement(728867..729175) 1 NC_011601.1 early gene regulator 729175 7063499 E2348C_0670 Escherichia coli O127:H6 str. E2348/69 early gene regulator YP_002328239.1 728867 R 574521 CDS YP_002328240.1 215485809 7063500 complement(729618..730442) 1 NC_011601.1 hypothetical protein 730442 7063500 E2348C_0671 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328240.1 729618 R 574521 CDS YP_002328241.1 215485810 7063501 complement(730647..731354) 1 NC_011601.1 repressor protein 731354 7063501 E2348C_0672 Escherichia coli O127:H6 str. E2348/69 repressor protein YP_002328241.1 730647 R 574521 CDS YP_002328242.1 215485811 7063502 731433..731660 1 NC_011601.1 antirepressor protein 731660 7063502 E2348C_0673 Escherichia coli O127:H6 str. E2348/69 antirepressor protein YP_002328242.1 731433 D 574521 CDS YP_002328243.1 215485812 7063503 731767..732066 1 NC_011601.1 regulatory protein 732066 7063503 E2348C_0674 Escherichia coli O127:H6 str. E2348/69 regulatory protein YP_002328243.1 731767 D 574521 CDS YP_002328244.1 215485813 7063505 732229..733005 1 NC_011601.1 replication protein 733005 7063505 E2348C_0675 Escherichia coli O127:H6 str. E2348/69 replication protein YP_002328244.1 732229 D 574521 CDS YP_002328245.1 215485814 7063585 733113..734993 1 NC_011601.1 replication protein 734993 7063585 E2348C_0676 Escherichia coli O127:H6 str. E2348/69 replication protein YP_002328245.1 733113 D 574521 CDS YP_002328246.1 215485815 7063586 735071..735511 1 NC_011601.1 protein NinB 735511 7063586 E2348C_0677 Escherichia coli O127:H6 str. E2348/69 protein NinB YP_002328246.1 735071 D 574521 CDS YP_002328247.1 215485816 7063587 735508..735690 1 NC_011601.1 protein NinE 735690 7063587 E2348C_0678 Escherichia coli O127:H6 str. E2348/69 protein NinE YP_002328247.1 735508 D 574521 CDS YP_002328248.1 215485817 7063588 735687..735866 1 NC_011601.1 protein NinF 735866 7063588 E2348C_0679 Escherichia coli O127:H6 str. E2348/69 protein NinF YP_002328248.1 735687 D 574521 CDS YP_002328249.1 215485818 7063589 735907..736335 1 NC_011601.1 endonuclease 736335 7063589 E2348C_0680 Escherichia coli O127:H6 str. E2348/69 endonuclease YP_002328249.1 735907 D 574521 CDS YP_002328250.1 215485819 7063590 736389..736781 1 NC_011601.1 hypothetical protein 736781 7063590 E2348C_0681 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328250.1 736389 D 574521 CDS YP_002328251.1 215485820 7063591 736774..737064 1 NC_011601.1 hypothetical protein 737064 7063591 E2348C_0682 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328251.1 736774 D 574521 CDS YP_002328252.1 215485821 7063592 complement(737195..737554) 1 NC_011601.1 hypothetical protein 737554 7063592 E2348C_0683 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328252.1 737195 R 574521 CDS YP_002328253.1 215485822 7063593 complement(737820..738779) 1 NC_011601.1 SfpA (systemic factor protein A)-like protein 738779 7063593 E2348C_0684 Escherichia coli O127:H6 str. E2348/69 SfpA (systemic factor protein A)-like protein YP_002328253.1 737820 R 574521 CDS YP_002328254.1 215485823 7063594 739255..739944 1 NC_011601.1 late gene regulator 739944 7063594 E2348C_0685 Escherichia coli O127:H6 str. E2348/69 late gene regulator YP_002328254.1 739255 D 574521 CDS YP_002328255.1 215485824 7063595 740156..740872 1 NC_011601.1 membrane protein 740872 7063595 E2348C_0686 Escherichia coli O127:H6 str. E2348/69 membrane protein YP_002328255.1 740156 D 574521 CDS YP_002328256.1 215485825 7063596 740958..741116 1 NC_011601.1 hypothetical protein 741116 7063596 E2348C_0687 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328256.1 740958 D 574521 CDS YP_002328257.1 215485826 7063597 741415..743265 1 NC_011601.1 hypothetical protein 743265 7063597 E2348C_0688 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328257.1 741415 D 574521 CDS YP_002328258.1 215485827 7063598 743713..743919 1 NC_011601.1 holin protein 743919 7063598 E2348C_0689 Escherichia coli O127:H6 str. E2348/69 holin protein YP_002328258.1 743713 D 574521 CDS YP_002328259.1 215485828 7063599 743919..744416 1 NC_011601.1 endolysin 744416 7063599 E2348C_0690 Escherichia coli O127:H6 str. E2348/69 endolysin YP_002328259.1 743919 D 574521 CDS YP_002328260.1 215485829 7063600 744413..744850 1 NC_011601.1 endopeptidase 744850 7063600 E2348C_0691 Escherichia coli O127:H6 str. E2348/69 endopeptidase YP_002328260.1 744413 D 574521 CDS YP_002328261.1 215485830 7063601 744612..744797 1 NC_011601.1 lipoprotein Rz1 744797 7063601 E2348C_0692 Escherichia coli O127:H6 str. E2348/69 lipoprotein Rz1 YP_002328261.1 744612 D 574521 CDS YP_002328262.1 215485831 7063602 745000..745617 1 NC_011601.1 hypothetical protein 745617 7063602 E2348C_0693 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328262.1 745000 D 574521 CDS YP_002328263.1 215485832 7063603 complement(745805..745999) 1 NC_011601.1 hypothetical protein 745999 7063603 E2348C_0694 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328263.1 745805 R 574521 CDS YP_002328264.1 215485833 7063604 746394..746903 1 NC_011601.1 terminase small subunit 746903 7063604 E2348C_0695 Escherichia coli O127:H6 str. E2348/69 terminase small subunit YP_002328264.1 746394 D 574521 CDS YP_002328265.1 215485834 7063605 746875..748803 1 NC_011601.1 terminase large subunit 748803 7063605 E2348C_0696 Escherichia coli O127:H6 str. E2348/69 terminase large subunit YP_002328265.1 746875 D 574521 CDS YP_002328266.1 215485835 7063606 748787..748993 1 NC_011601.1 head-tail joining protein 748993 7063606 E2348C_0697 Escherichia coli O127:H6 str. E2348/69 head-tail joining protein YP_002328266.1 748787 D 574521 CDS YP_002328267.1 215485836 7063607 748990..750582 1 NC_011601.1 portal protein 750582 7063607 E2348C_0698 Escherichia coli O127:H6 str. E2348/69 portal protein YP_002328267.1 748990 D 574521 CDS YP_002328268.1 215485837 7063608 750572..752077 1 NC_011601.1 head protein/prohead protease 752077 7063608 E2348C_0699 Escherichia coli O127:H6 str. E2348/69 head protein/prohead protease YP_002328268.1 750572 D 574521 CDS YP_002328269.1 215485838 7063609 752114..752461 1 NC_011601.1 head-DNA stabilization protein 752461 7063609 E2348C_0700 Escherichia coli O127:H6 str. E2348/69 head-DNA stabilization protein YP_002328269.1 752114 D 574521 CDS YP_002328270.1 215485839 7063610 752519..753547 1 NC_011601.1 major capsid protein 753547 7063610 E2348C_0701 Escherichia coli O127:H6 str. E2348/69 major capsid protein YP_002328270.1 752519 D 574521 CDS YP_002328271.1 215485840 7063611 753599..753973 1 NC_011601.1 DNA packaging protein 753973 7063611 E2348C_0702 Escherichia coli O127:H6 str. E2348/69 DNA packaging protein YP_002328271.1 753599 D 574521 CDS YP_002328272.1 215485841 7063612 753966..754319 1 NC_011601.1 head-tail adapotor 754319 7063612 E2348C_0703 Escherichia coli O127:H6 str. E2348/69 head-tail adapotor YP_002328272.1 753966 D 574521 CDS YP_002328273.1 215485842 7063613 754334..754867 1 NC_011601.1 minor tail protein 754867 7063613 E2348C_0704 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328273.1 754334 D 574521 CDS YP_002328274.1 215485843 7063614 754864..755259 1 NC_011601.1 minor tail protein 755259 7063614 E2348C_0705 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328274.1 754864 D 574521 CDS YP_002328275.1 215485844 7063615 755267..756019 1 NC_011601.1 major tail protein 756019 7063615 E2348C_0706 Escherichia coli O127:H6 str. E2348/69 major tail protein YP_002328275.1 755267 D 574521 CDS YP_002328276.1 215485845 7063616 756033..756464 1 NC_011601.1 minor tail protein 756464 7063616 E2348C_0707 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328276.1 756033 D 574521 CDS YP_002328277.1 215485846 7063617 756491..756904 1 NC_011601.1 minor tail protein 756904 7063617 E2348C_0708 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328277.1 756491 D 574521 CDS YP_002328278.1 215485847 7063618 756885..759446 1 NC_011601.1 tail length tape measure protein 759446 7063618 E2348C_0709 Escherichia coli O127:H6 str. E2348/69 tail length tape measure protein YP_002328278.1 756885 D 574521 CDS YP_002328279.1 215485848 7063619 759443..759772 1 NC_011601.1 minor tail protein 759772 7063619 E2348C_0710 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328279.1 759443 D 574521 CDS YP_002328280.1 215485849 7063620 759772..760470 1 NC_011601.1 minor tail protein 760470 7063620 E2348C_0711 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328280.1 759772 D 574521 CDS YP_002328281.1 215485850 7063621 760476..761219 1 NC_011601.1 tail assembly protein 761219 7063621 E2348C_0712 Escherichia coli O127:H6 str. E2348/69 tail assembly protein YP_002328281.1 760476 D 574521 CDS YP_002328282.1 215485851 7063622 761117..761758 1 NC_011601.1 tail assembly protein 761758 7063622 E2348C_0713 Escherichia coli O127:H6 str. E2348/69 tail assembly protein YP_002328282.1 761117 D 574521 CDS YP_002328283.1 215485852 7063623 761819..765232 1 NC_011601.1 host specificity protein 765232 7063623 E2348C_0714 Escherichia coli O127:H6 str. E2348/69 host specificity protein YP_002328283.1 761819 D 574521 CDS YP_002328284.1 215485853 7063624 765302..765901 1 NC_011601.1 outer membrane precursor Lom 765901 7063624 E2348C_0715 Escherichia coli O127:H6 str. E2348/69 outer membrane precursor Lom YP_002328284.1 765302 D 574521 CDS YP_002328285.1 215485854 7063625 765966..767279 1 NC_011601.1 side tail fiber protein 767279 7063625 E2348C_0716 Escherichia coli O127:H6 str. E2348/69 side tail fiber protein YP_002328285.1 765966 D 574521 CDS YP_002328286.1 215485855 7063626 767281..767550 1 NC_011601.1 hypothetical protein 767550 7063626 E2348C_0717 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328286.1 767281 D 574521 CDS YP_002328287.1 215485856 7063627 767656..768537 1 NC_011601.1 T3SS secreted effector NleH-like protein 768537 7063627 E2348C_0718 Escherichia coli O127:H6 str. E2348/69 T3SS secreted effector NleH-like protein YP_002328287.1 767656 D 574521 CDS YP_002328288.1 215485857 7063629 770013..770393 1 NC_011601.1 hypothetical protein 770393 7063629 E2348C_0721 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328288.1 770013 D 574521 CDS YP_002328289.1 215485858 7063630 770477..770698 1 NC_011601.1 hypothetical protein 770698 7063630 E2348C_0722 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328289.1 770477 D 574521 CDS YP_002328290.1 215485859 7063631 complement(770711..771364) 1 NC_011601.1 T3SS secreted effector EspJ-like protein 771364 7063631 E2348C_0723 Escherichia coli O127:H6 str. E2348/69 T3SS secreted effector EspJ-like protein YP_002328290.1 770711 R 574521 CDS YP_002328291.1 215485860 7063632 complement(771868..772344) 1 NC_011601.1 YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein 772344 ybhB 7063632 ybhB Escherichia coli O127:H6 str. E2348/69 kinase inhibitor protein YP_002328291.1 771868 R 574521 CDS YP_002328292.1 215485861 7063279 772453..773583 1 NC_011601.1 Peyer's patch-specific virulence factor GipA, transposase-like 773583 gipA 7063279 gipA Escherichia coli O127:H6 str. E2348/69 Peyer's patch-specific virulence factor GipA, transposase-like YP_002328292.1 772453 D 574521 CDS YP_002328293.1 215485862 7061657 complement(773694..774983) 1 NC_011601.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 774983 bioA 7061657 bioA Escherichia coli O127:H6 str. E2348/69 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_002328293.1 773694 R 574521 CDS YP_002328294.1 215485863 7062520 775070..776110 1 NC_011601.1 biotin synthase 776110 bioB 7062520 bioB Escherichia coli O127:H6 str. E2348/69 biotin synthase YP_002328294.1 775070 D 574521 CDS YP_002328295.1 215485864 7062521 776107..777261 1 NC_011601.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 777261 bioF 7062521 bioF Escherichia coli O127:H6 str. E2348/69 8-amino-7-oxononanoate synthase YP_002328295.1 776107 D 574521 CDS YP_002328296.1 215485865 7062524 777248..778003 1 NC_011601.1 methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 778003 bioC 7062524 bioC Escherichia coli O127:H6 str. E2348/69 biotin biosynthesis protein BioC YP_002328296.1 777248 D 574521 CDS YP_002328297.1 215485866 7062522 777996..778673 1 NC_011601.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 778673 bioD 7062522 bioD Escherichia coli O127:H6 str. E2348/69 dithiobiotin synthetase YP_002328297.1 777996 D 574521 CDS YP_002328298.1 215485867 7062523 779252..781273 1 NC_011601.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 781273 uvrB 7062523 uvrB Escherichia coli O127:H6 str. E2348/69 excinuclease ABC subunit B YP_002328298.1 779252 D 574521 CDS YP_002328299.1 215485868 7062341 complement(781311..782219) 1 NC_011601.1 transferase with NAD(P)-binding Rossmann-fold domain 782219 ybhK 7062341 ybhK Escherichia coli O127:H6 str. E2348/69 transferase with NAD(P)-binding Rossmann-fold domain YP_002328299.1 781311 R 574521 CDS YP_002328300.1 215485869 7063287 782616..783605 1 NC_011601.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 783605 moaA 7063287 moaA Escherichia coli O127:H6 str. E2348/69 molybdenum cofactor biosynthesis protein A YP_002328300.1 782616 D 574521 CDS YP_002328301.1 215485870 7063805 783627..784139 1 NC_011601.1 molybdopterin biosynthesis protein B 784139 moaB 7063805 moaB Escherichia coli O127:H6 str. E2348/69 molybdopterin biosynthesis protein B YP_002328301.1 783627 D 574521 CDS YP_002328302.1 215485871 7063806 784142..784627 1 NC_011601.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 784627 moaC 7063806 moaC Escherichia coli O127:H6 str. E2348/69 molybdenum cofactor biosynthesis protein MoaC YP_002328302.1 784142 D 574521 CDS YP_002328303.1 215485872 7063807 784620..784865 1 NC_011601.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 784865 moaD 7063807 moaD Escherichia coli O127:H6 str. E2348/69 molybdopterin synthase small subunit YP_002328303.1 784620 D 574521 CDS YP_002328304.1 215485873 7063808 784867..785319 1 NC_011601.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 785319 moaE 7063808 moaE Escherichia coli O127:H6 str. E2348/69 molybdopterin guanine dinucleotide biosynthesis protein MoaE YP_002328304.1 784867 D 574521 CDS YP_002328305.1 215485874 7063809 785456..786160 1 NC_011601.1 hypothetical protein 786160 ybhL 7063809 ybhL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328305.1 785456 D 574521 CDS YP_002328306.1 215485875 7063288 786365..787078 1 NC_011601.1 hypothetical protein 787078 ybhM 7063288 ybhM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328306.1 786365 D 574521 CDS YP_002328307.1 215485876 7063289 complement(787114..788070) 1 NC_011601.1 hypothetical protein 788070 ybhN 7063289 ybhN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328307.1 787114 R 574521 CDS YP_002328308.1 215485877 7063290 complement(788070..789311) 1 NC_011601.1 cardiolipin synthase 2 789311 ybhO 7063290 ybhO Escherichia coli O127:H6 str. E2348/69 cardiolipin synthase 2 YP_002328308.1 788070 R 574521 CDS YP_002328309.1 215485878 7063291 complement(789308..790069) 1 NC_011601.1 DNase 790069 ybhP 7063291 ybhP Escherichia coli O127:H6 str. E2348/69 DNase YP_002328309.1 789308 R 574521 CDS YP_002328310.1 215485879 7063292 790202..790612 1 NC_011601.1 hypothetical protein 790612 ybhQ 7063292 ybhQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328310.1 790202 D 574521 CDS YP_002328311.1 215485880 7063293 complement(790574..791680) 1 NC_011601.1 DNase 791680 ybhR 7063293 ybhR Escherichia coli O127:H6 str. E2348/69 DNase YP_002328311.1 790574 R 574521 CDS YP_002328312.1 215485881 7063294 complement(791691..792824) 1 NC_011601.1 transporter subunit: membrane component of ABC superfamily 792824 ybhS 7063294 ybhS Escherichia coli O127:H6 str. E2348/69 transporter subunit: membrane component of ABC superfamily YP_002328312.1 791691 R 574521 CDS YP_002328313.1 215485882 7063295 complement(792817..794553) 1 NC_011601.1 fused transporter subunits of ABC superfamily: ATP-binding components 794553 ybhF 7063295 ybhF Escherichia coli O127:H6 str. E2348/69 fused transporter subunits of ABC superfamily: ATP-binding components YP_002328313.1 792817 R 574521 CDS YP_002328314.1 215485883 7063282 complement(794546..795544) 1 NC_011601.1 hypothetical protein 795544 ybhG 7063282 ybhG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328314.1 794546 R 574521 CDS YP_002328315.1 215485884 7063283 complement(795544..796215) 1 NC_011601.1 DNA-binding transcriptional regulator 796215 ybiH 7063283 ybiH Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002328315.1 795544 R 574521 CDS YP_002328316.1 215485885 7063300 796444..797805 1 NC_011601.1 this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 797805 rhlE 7063300 rhlE Escherichia coli O127:H6 str. E2348/69 ATP-dependent RNA helicase RhlE YP_002328316.1 796444 D 574521 CDS YP_002328317.1 215485886 7063297 798342..800492 1 NC_011601.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 800492 dinG 7063297 dinG Escherichia coli O127:H6 str. E2348/69 ATP-dependent DNA helicase DinG YP_002328317.1 798342 D 574521 CDS YP_002328318.1 215485887 7065031 800520..801482 1 NC_011601.1 glycosyl transferase family protein 801482 ybiB 7065031 ybiB Escherichia coli O127:H6 str. E2348/69 glycosyl transferase family protein YP_002328318.1 800520 D 574521 CDS YP_002328319.1 215485888 7063298 801623..802708 1 NC_011601.1 hypothetical protein 802708 ybiC 7063298 ybiC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328319.1 801623 D 574521 CDS YP_002328320.1 215485889 7063299 complement(802936..803196) 1 NC_011601.1 hypothetical protein 803196 ybiJ 7063299 ybiJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328320.1 802936 R 574521 CDS YP_002328321.1 215485890 7063302 complement(803461..803727) 1 NC_011601.1 hypothetical protein 803727 ybiI 7063302 ybiI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328321.1 803461 R 574521 CDS YP_002328322.1 215485891 7063301 complement(803801..804478) 1 NC_011601.1 hydroxylase 804478 ybiX 7063301 ybiX Escherichia coli O127:H6 str. E2348/69 hydroxylase YP_002328322.1 803801 R 574521 CDS YP_002328323.1 215485892 7063312 complement(804520..806802) 1 NC_011601.1 Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu 806802 fiu 7063312 fiu Escherichia coli O127:H6 str. E2348/69 catecholate siderophore receptor Fiu YP_002328323.1 804520 R 574521 CDS YP_002328324.1 215485893 7062129 complement(807067..807327) 1 NC_011601.1 hypothetical protein 807327 ybiM 7062129 ybiM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328324.1 807067 R 574521 CDS YP_002328325.1 215485894 7063303 807603..808529 1 NC_011601.1 SAM-dependent methyltransferase 808529 ybiN 7063303 ybiN Escherichia coli O127:H6 str. E2348/69 SAM-dependent methyltransferase YP_002328325.1 807603 D 574521 CDS YP_002328326.1 215485895 7063304 complement(808526..810751) 1 NC_011601.1 hypothetical protein 810751 ybiO 7063304 ybiO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328326.1 808526 R 574521 CDS YP_002328327.1 215485896 7063305 complement(810868..811590) 1 NC_011601.1 similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein 811590 glnQ 7063305 glnQ Escherichia coli O127:H6 str. E2348/69 glutamine ABC transporter ATP-binding protein YP_002328327.1 810868 R 574521 CDS YP_002328328.1 215485897 7061685 complement(811587..812246) 1 NC_011601.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 812246 glnP 7061685 glnP Escherichia coli O127:H6 str. E2348/69 glutamine ABC transporter permease YP_002328328.1 811587 R 574521 CDS YP_002328329.1 215485898 7061684 complement(812388..813134) 1 NC_011601.1 similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein 813134 glnH 7061684 glnH Escherichia coli O127:H6 str. E2348/69 glutamine ABC transporter periplasmic protein YP_002328329.1 812388 R 574521 CDS YP_002328330.1 215485899 7061681 complement(813538..814041) 1 NC_011601.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 814041 dps 7061681 dps Escherichia coli O127:H6 str. E2348/69 DNA starvation/stationary phase protection protein Dps YP_002328330.1 813538 R 574521 CDS YP_002328331.1 215485900 7065061 complement(814341..815228) 1 NC_011601.1 threonine and homoserine efflux system 815228 rhtA 7065061 rhtA Escherichia coli O127:H6 str. E2348/69 threonine and homoserine efflux system YP_002328331.1 814341 R 574521 CDS YP_002328332.1 215485901 7060814 815581..816096 1 NC_011601.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 816096 ompX 7060814 ompX Escherichia coli O127:H6 str. E2348/69 outer membrane protein X YP_002328332.1 815581 D 574521 CDS YP_002328333.1 215485902 7064967 816286..816744 1 NC_011601.1 transposase of IS200C 816744 7064967 E2348C_0767 Escherichia coli O127:H6 str. E2348/69 transposase of IS200C YP_002328333.1 816286 D 574521 CDS YP_002328334.1 215485903 7063633 complement(816857..818440) 1 NC_011601.1 hydrolase, inner membrane 818440 ybiP 7063633 ybiP Escherichia coli O127:H6 str. E2348/69 hydrolase, inner membrane YP_002328334.1 816857 R 574521 CDS YP_002328335.1 215485904 7064591 819026..819493 1 NC_011601.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 819493 mntR 7064591 mntR Escherichia coli O127:H6 str. E2348/69 manganese transport regulator MntR YP_002328335.1 819026 D 574521 CDS YP_002328336.1 215485905 7063804 819490..820608 1 NC_011601.1 transporter 820608 ybiR 7063804 ybiR Escherichia coli O127:H6 str. E2348/69 transporter YP_002328336.1 819490 D 574521 CDS YP_002328337.1 215485906 7063307 complement(820666..821586) 1 NC_011601.1 hypothetical protein 821586 ybiS 7063307 ybiS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328337.1 820666 R 574521 CDS YP_002328338.1 215485907 7063308 821805..823397 1 NC_011601.1 fused transporter subunits of ABC superfamily: ATP-binding components 823397 ybiT 7063308 ybiT Escherichia coli O127:H6 str. E2348/69 fused transporter subunits of ABC superfamily: ATP-binding components YP_002328338.1 821805 D 574521 CDS YP_002328339.1 215485908 7063309 complement(823597..824412) 1 NC_011601.1 hydrolase 824412 ybiV 7063309 ybiV Escherichia coli O127:H6 str. E2348/69 hydrolase YP_002328339.1 823597 R 574521 CDS YP_002328340.1 215485909 7063310 complement(824557..826989) 1 NC_011601.1 pyruvate formate lyase 826989 ybiW 7063310 ybiW Escherichia coli O127:H6 str. E2348/69 pyruvate formate lyase YP_002328340.1 824557 R 574521 CDS YP_002328341.1 215485910 7063311 complement(826995..827894) 1 NC_011601.1 pyruvate formate lyase activating enzyme 827894 ybiY 7063311 ybiY Escherichia coli O127:H6 str. E2348/69 pyruvate formate lyase activating enzyme YP_002328341.1 826995 R 574521 CDS YP_002328342.1 215485911 7063313 828025..828687 1 NC_011601.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 828687 fsaA 7063313 fsaA Escherichia coli O127:H6 str. E2348/69 fructose-6-phosphate aldolase YP_002328342.1 828025 D 574521 CDS YP_002328343.1 215485912 7061973 complement(828763..829512) 1 NC_011601.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 829512 moeB 7061973 moeB Escherichia coli O127:H6 str. E2348/69 molybdopterin biosynthesis protein MoeB YP_002328343.1 828763 R 574521 CDS YP_002328344.1 215485913 7063818 complement(829512..830747) 1 NC_011601.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 830747 moeA 7063818 moeA Escherichia coli O127:H6 str. E2348/69 molybdopterin biosynthesis protein MoeA YP_002328344.1 829512 R 574521 CDS YP_002328345.1 215485914 7063817 830951..831916 1 NC_011601.1 L-asparaginase 831916 iaaA 7063817 iaaA Escherichia coli O127:H6 str. E2348/69 L-asparaginase YP_002328345.1 830951 D 574521 CDS YP_002328346.1 215485915 7063512 831903..833774 1 NC_011601.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 833774 gsiA 7063512 gsiA Escherichia coli O127:H6 str. E2348/69 glutathione transporter ATP-binding protein YP_002328346.1 831903 D 574521 CDS YP_002328347.1 215485916 7064252 833794..835332 1 NC_011601.1 peptide transporter subunit: periplasmic-binding component of ABC superfamily 835332 gsiB 7064252 gsiB Escherichia coli O127:H6 str. E2348/69 peptide transporter subunit: periplasmic-binding component of ABC superfamily YP_002328347.1 833794 D 574521 CDS YP_002328348.1 215485917 7064253 835350..836270 1 NC_011601.1 peptide transporter subunit: membrane component of ABC superfamily 836270 gsiC 7064253 gsiC Escherichia coli O127:H6 str. E2348/69 peptide transporter subunit: membrane component of ABC superfamily YP_002328348.1 835350 D 574521 CDS YP_002328349.1 215485918 7064254 836273..837184 1 NC_011601.1 peptide transporter subunit: membrane component of ABC superfamily 837184 gsiD 7064254 gsiD Escherichia coli O127:H6 str. E2348/69 peptide transporter subunit: membrane component of ABC superfamily YP_002328349.1 836273 D 574521 CDS YP_002328350.1 215485919 7064255 837361..839709 1 NC_011601.1 hypothetical protein 839709 yliE 7064255 yliE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328350.1 837361 D 574521 CDS YP_002328351.1 215485920 7062015 839717..841045 1 NC_011601.1 diguanylate cyclase 841045 yliF 7062015 yliF Escherichia coli O127:H6 str. E2348/69 diguanylate cyclase YP_002328351.1 839717 D 574521 CDS YP_002328352.1 215485921 7062016 complement(841092..842417) 1 NC_011601.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 842417 rimO 7062016 rimO Escherichia coli O127:H6 str. E2348/69 ribosomal protein S12 methylthiotransferase YP_002328352.1 841092 R 574521 CDS YP_002328353.1 215485922 7062017 842630..843013 1 NC_011601.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 843013 bssR 7062017 bssR Escherichia coli O127:H6 str. E2348/69 biofilm formation regulatory protein BssR YP_002328353.1 842630 D 574521 CDS YP_002328354.1 215485923 7062532 843124..844239 1 NC_011601.1 dehydrogenase 844239 yliI 7062532 yliI Escherichia coli O127:H6 str. E2348/69 dehydrogenase YP_002328354.1 843124 D 574521 CDS YP_002328355.1 215485924 7062018 complement(844236..844862) 1 NC_011601.1 glutathione S-transferase 844862 yliJ 7062018 yliJ Escherichia coli O127:H6 str. E2348/69 glutathione S-transferase YP_002328355.1 844236 R 574521 CDS YP_002328356.1 215485925 7062019 845109..846311 1 NC_011601.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 846311 dacC 7062019 dacC Escherichia coli O127:H6 str. E2348/69 D-alanyl-D-alanine carboxypeptidase YP_002328356.1 845109 D 574521 CDS YP_002328357.1 215485926 7065214 complement(846358..847116) 1 NC_011601.1 DNA-binding transcriptional repressor DeoR 847116 deoR 7065214 deoR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor DeoR YP_002328357.1 846358 R 574521 CDS YP_002328358.1 215485927 7065011 complement(847174..847770) 1 NC_011601.1 undecaprenyl pyrophosphate phosphatase 847770 ybjG 7065011 ybjG Escherichia coli O127:H6 str. E2348/69 undecaprenyl pyrophosphate phosphatase YP_002328358.1 847174 R 574521 CDS YP_002328359.1 215485928 7063317 848055..849287 1 NC_011601.1 multidrug efflux system protein 849287 cmr 7063317 cmr Escherichia coli O127:H6 str. E2348/69 multidrug efflux system protein YP_002328359.1 848055 D 574521 CDS YP_002328360.1 215485929 7062817 complement(849328..849612) 1 NC_011601.1 hypothetical protein 849612 ybjH 7062817 ybjH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328360.1 849328 R 574521 CDS YP_002328361.1 215485930 7063318 complement(849698..850513) 1 NC_011601.1 hypothetical protein 850513 ybjI 7063318 ybjI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328361.1 849698 R 574521 CDS YP_002328362.1 215485931 7063319 complement(850513..851721) 1 NC_011601.1 transporter 851721 ybjJ 7063319 ybjJ Escherichia coli O127:H6 str. E2348/69 transporter YP_002328362.1 850513 R 574521 CDS YP_002328363.1 215485932 7063320 851805..852341 1 NC_011601.1 DNA-binding transcriptional regulator 852341 ybjK 7063320 ybjK Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002328363.1 851805 D 574521 CDS YP_002328364.1 215485933 7061167 complement(852446..853498) 1 NC_011601.1 integrase 853498 7061167 E2348C_0798 Escherichia coli O127:H6 str. E2348/69 integrase YP_002328364.1 852446 R 574521 CDS YP_002328365.1 215485934 7063634 complement(853585..855102) 1 NC_011601.1 hypothetical protein 855102 7063634 E2348C_0799 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328365.1 853585 R 574521 CDS YP_002328366.1 215485935 7063635 complement(855128..856051) 1 NC_011601.1 hypothetical protein 856051 7063635 E2348C_0800 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328366.1 855128 R 574521 CDS YP_002328367.1 215485936 7063636 complement(856102..856671) 1 NC_011601.1 repressor protein 856671 7063636 E2348C_0801 Escherichia coli O127:H6 str. E2348/69 repressor protein YP_002328367.1 856102 R 574521 CDS YP_002328368.1 215485937 7063637 856797..857018 1 NC_011601.1 regulatory protein 857018 7063637 E2348C_0802 Escherichia coli O127:H6 str. E2348/69 regulatory protein YP_002328368.1 856797 D 574521 CDS YP_002328369.1 215485938 7063638 857051..857560 1 NC_011601.1 regulatory protein 857560 7063638 E2348C_0803 Escherichia coli O127:H6 str. E2348/69 regulatory protein YP_002328369.1 857051 D 574521 CDS YP_002328370.1 215485939 7063639 857568..857768 1 NC_011601.1 hypothetical protein 857768 7063639 E2348C_0804 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328370.1 857568 D 574521 CDS YP_002328371.1 215485940 7063640 857732..858073 1 NC_011601.1 hypothetical protein 858073 7063640 E2348C_0805 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328371.1 857732 D 574521 CDS YP_002328372.1 215485941 7063641 858141..858374 1 NC_011601.1 hypothetical protein 858374 7063641 E2348C_0806 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328372.1 858141 D 574521 CDS YP_002328373.1 215485942 7063642 858374..858601 1 NC_011601.1 TraR/DksA family transcriptional regulator 858601 7063642 E2348C_0807 Escherichia coli O127:H6 str. E2348/69 TraR/DksA family transcriptional regulator YP_002328373.1 858374 D 574521 CDS YP_002328374.1 215485943 7063643 858598..859455 1 NC_011601.1 DNA adenine methylase 859455 7063643 E2348C_0808 Escherichia coli O127:H6 str. E2348/69 DNA adenine methylase YP_002328374.1 858598 D 574521 CDS YP_002328375.1 215485944 7063644 859452..861866 1 NC_011601.1 replication protein 861866 7063644 E2348C_0809 Escherichia coli O127:H6 str. E2348/69 replication protein YP_002328375.1 859452 D 574521 CDS YP_002328376.1 215485945 7063645 862021..862209 1 NC_011601.1 hypothetical protein 862209 7063645 E2348C_0810 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328376.1 862021 D 574521 CDS YP_002328377.1 215485946 7063646 862220..862453 1 NC_011601.1 DNA-damage-inducible protein 862453 7063646 E2348C_0811 Escherichia coli O127:H6 str. E2348/69 DNA-damage-inducible protein YP_002328377.1 862220 D 574521 CDS YP_002328378.1 215485947 7063647 complement(862646..862981) 1 NC_011601.1 hypothetical protein 862981 7063647 E2348C_0812 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328378.1 862646 R 574521 CDS YP_002328379.1 215485948 7063648 863253..863525 1 NC_011601.1 hypothetical protein 863525 7063648 E2348C_0813 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328379.1 863253 D 574521 CDS YP_002328380.1 215485949 7063649 863510..864085 1 NC_011601.1 hypothetical protein 864085 7063649 E2348C_0814 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328380.1 863510 D 574521 CDS YP_002328381.1 215485950 7063650 864090..865049 1 NC_011601.1 hypothetical protein 865049 7063650 E2348C_0815 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328381.1 864090 D 574521 CDS YP_002328382.1 215485951 7063651 complement(865074..866099) 1 NC_011601.1 capsid portal protein 866099 7063651 E2348C_0816 Escherichia coli O127:H6 str. E2348/69 capsid portal protein YP_002328382.1 865074 R 574521 CDS YP_002328383.1 215485952 7063652 complement(866099..867865) 1 NC_011601.1 terminase, ATPase subunit 867865 7063652 E2348C_0817 Escherichia coli O127:H6 str. E2348/69 terminase, ATPase subunit YP_002328383.1 866099 R 574521 CDS YP_002328384.1 215485953 7063653 868008..868841 1 NC_011601.1 capsid scaffolding protein 868841 7063653 E2348C_0818 Escherichia coli O127:H6 str. E2348/69 capsid scaffolding protein YP_002328384.1 868008 D 574521 CDS YP_002328385.1 215485954 7063654 868858..869916 1 NC_011601.1 major capsid protein 869916 7063654 E2348C_0819 Escherichia coli O127:H6 str. E2348/69 major capsid protein YP_002328385.1 868858 D 574521 CDS YP_002328386.1 215485955 7063655 869920..870570 1 NC_011601.1 terminase, endonuclease subunit 870570 7063655 E2348C_0820 Escherichia coli O127:H6 str. E2348/69 terminase, endonuclease subunit YP_002328386.1 869920 D 574521 CDS YP_002328387.1 215485956 7063656 870666..871130 1 NC_011601.1 capsid completion protein 871130 7063656 E2348C_0821 Escherichia coli O127:H6 str. E2348/69 capsid completion protein YP_002328387.1 870666 D 574521 CDS YP_002328388.1 215485957 7063657 871130..871333 1 NC_011601.1 tail protein 871333 7063657 E2348C_0822 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002328388.1 871130 D 574521 CDS YP_002328389.1 215485958 7063658 871337..871552 1 NC_011601.1 secretory protein 871552 7063658 E2348C_0823 Escherichia coli O127:H6 str. E2348/69 secretory protein YP_002328389.1 871337 D 574521 CDS YP_002328390.1 215485959 7063659 871533..872045 1 NC_011601.1 lysozyme 872045 7063659 E2348C_0824 Escherichia coli O127:H6 str. E2348/69 lysozyme YP_002328390.1 871533 D 574521 CDS YP_002328391.1 215485960 7063660 872047..872424 1 NC_011601.1 membrane protein 872424 7063660 E2348C_0825 Escherichia coli O127:H6 str. E2348/69 membrane protein YP_002328391.1 872047 D 574521 CDS YP_002328392.1 215485961 7063661 872421..872849 1 NC_011601.1 regulatory protein 872849 7063661 E2348C_0826 Escherichia coli O127:H6 str. E2348/69 regulatory protein YP_002328392.1 872421 D 574521 CDS YP_002328393.1 215485962 7063662 872945..873376 1 NC_011601.1 tail protein 873376 7063662 E2348C_0827 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002328393.1 872945 D 574521 CDS YP_002328394.1 215485963 7060860 complement(873731..874792) 1 NC_011601.1 variable tail fiber protein 874792 7060860 E2348C_0829 Escherichia coli O127:H6 str. E2348/69 variable tail fiber protein YP_002328394.1 873731 R 574521 CDS YP_002328395.1 215485964 7061019 complement(874789..875394) 1 NC_011601.1 tail protein 875394 7061019 E2348C_0830 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002328395.1 874789 R 574521 CDS YP_002328396.1 215485965 7061020 complement(875387..876295) 1 NC_011601.1 baseplate assembly protein 876295 7061020 E2348C_0831 Escherichia coli O127:H6 str. E2348/69 baseplate assembly protein YP_002328396.1 875387 R 574521 CDS YP_002328397.1 215485966 7061021 complement(876282..876641) 1 NC_011601.1 baseplate assembly protein 876641 7061021 E2348C_0832 Escherichia coli O127:H6 str. E2348/69 baseplate assembly protein YP_002328397.1 876282 R 574521 CDS YP_002328398.1 215485967 7061022 complement(876638..877216) 1 NC_011601.1 baseplate assembly protein 877216 7061022 E2348C_0833 Escherichia coli O127:H6 str. E2348/69 baseplate assembly protein YP_002328398.1 876638 R 574521 CDS YP_002328399.1 215485968 7061023 877308..878453 1 NC_011601.1 hypothetical protein 878453 7061023 E2348C_0834 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328399.1 877308 D 574521 CDS YP_002328400.1 215485969 7061024 878571..879137 1 NC_011601.1 DNA invertase 879137 7061024 E2348C_0835 Escherichia coli O127:H6 str. E2348/69 DNA invertase YP_002328400.1 878571 D 574521 CDS YP_002328401.1 215485970 7061025 879280..880452 1 NC_011601.1 major tail sheath protein 880452 7061025 E2348C_0836 Escherichia coli O127:H6 str. E2348/69 major tail sheath protein YP_002328401.1 879280 D 574521 CDS YP_002328402.1 215485971 7061026 880462..880977 1 NC_011601.1 major tail tube protein 880977 7061026 E2348C_0837 Escherichia coli O127:H6 str. E2348/69 major tail tube protein YP_002328402.1 880462 D 574521 CDS YP_002328403.1 215485972 7061027 881032..881334 1 NC_011601.1 tail protein 881334 7061027 E2348C_0838 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002328403.1 881032 D 574521 CDS YP_002328404.1 215485973 7061028 881349..881468 1 NC_011601.1 tail protein 881468 7061028 E2348C_0839 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002328404.1 881349 D 574521 CDS YP_002328405.1 215485974 7061029 881461..884538 1 NC_011601.1 tail tape measure protein 884538 7061029 E2348C_0840 Escherichia coli O127:H6 str. E2348/69 tail tape measure protein YP_002328405.1 881461 D 574521 CDS YP_002328406.1 215485975 7061030 884535..885020 1 NC_011601.1 tail protein 885020 7061030 E2348C_0841 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002328406.1 884535 D 574521 CDS YP_002328407.1 215485976 7061031 885017..886117 1 NC_011601.1 late gene regulator 886117 7061031 E2348C_0842 Escherichia coli O127:H6 str. E2348/69 late gene regulator YP_002328407.1 885017 D 574521 CDS YP_002328408.1 215485977 7061032 886205..886423 1 NC_011601.1 transcriptional activator 886423 7061032 E2348C_0843 Escherichia coli O127:H6 str. E2348/69 transcriptional activator YP_002328408.1 886205 D 574521 CDS YP_002328409.1 215485978 7064592 complement(886659..888344) 1 NC_011601.1 hypothetical protein 888344 ybjL 7064592 ybjL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328409.1 886659 R 574521 CDS YP_002328410.1 215485979 7063322 888614..888991 1 NC_011601.1 hypothetical protein 888991 ybjM 7063322 ybjM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328410.1 888614 D 574521 CDS YP_002328411.1 215485980 7063323 complement(889021..889278) 1 NC_011601.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 889278 grxA 7063323 grxA Escherichia coli O127:H6 str. E2348/69 glutaredoxin YP_002328411.1 889021 R 574521 CDS YP_002328412.1 215485981 7064246 889438..889725 1 NC_011601.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 889725 ybjC 7064246 ybjC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328412.1 889438 D 574521 CDS YP_002328413.1 215485982 7063314 889709..890431 1 NC_011601.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 890431 nfsA 7063314 nfsA Escherichia coli O127:H6 str. E2348/69 nitroreductase A YP_002328413.1 889709 D 574521 CDS YP_002328414.1 215485983 7065385 890492..891394 1 NC_011601.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 891394 rimK 7065385 rimK Escherichia coli O127:H6 str. E2348/69 ribosomal protein S6 modification protein YP_002328414.1 890492 D 574521 CDS YP_002328415.1 215485984 7060829 891482..891958 1 NC_011601.1 oxidoreductase 891958 ybjN 7060829 ybjN Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002328415.1 891482 D 574521 CDS YP_002328416.1 215485985 7063324 892308..893420 1 NC_011601.1 putrescine ABC transporter periplasmic-binding protein 893420 potF 7063324 potF Escherichia coli O127:H6 str. E2348/69 putrescine ABC transporter periplasmic-binding protein YP_002328416.1 892308 D 574521 CDS YP_002328417.1 215485986 7060775 893515..894648 1 NC_011601.1 part of the PotFGHI ATP-dependent putrescine transporter; putrescine ABC transporter ATP-binding protein 894648 potG 7060775 potG Escherichia coli O127:H6 str. E2348/69 putrescine ABC transporter ATP-binding protein YP_002328417.1 893515 D 574521 CDS YP_002328418.1 215485987 7060776 894658..895611 1 NC_011601.1 putrescine ABC transporter membrane protein 895611 potH 7060776 potH Escherichia coli O127:H6 str. E2348/69 putrescine ABC transporter membrane protein YP_002328418.1 894658 D 574521 CDS YP_002328419.1 215485988 7060777 895608..896453 1 NC_011601.1 putrescine ABC transporter membrane protein 896453 potI 7060777 potI Escherichia coli O127:H6 str. E2348/69 putrescine ABC transporter membrane protein YP_002328419.1 895608 D 574521 CDS YP_002328420.1 215485989 7060778 896513..897001 1 NC_011601.1 hypothetical protein 897001 ybjO 7060778 ybjO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328420.1 896513 D 574521 CDS YP_002328421.1 215485990 7063325 897042..898169 1 NC_011601.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 898169 rumB 7063325 rumB Escherichia coli O127:H6 str. E2348/69 23S rRNA methyluridine methyltransferase YP_002328421.1 897042 D 574521 CDS YP_002328422.1 215485991 7064579 complement(898198..898929) 1 NC_011601.1 arginine ABC transporter substrate-binding protein 898929 artJ 7064579 artJ Escherichia coli O127:H6 str. E2348/69 arginine ABC transporter substrate-binding protein YP_002328422.1 898198 R 574521 CDS YP_002328423.1 215485992 7061403 complement(899155..899823) 1 NC_011601.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 899823 artM 7061403 artM Escherichia coli O127:H6 str. E2348/69 arginine transporter permease subunit ArtM YP_002328423.1 899155 R 574521 CDS YP_002328424.1 215485993 7061404 complement(899823..900539) 1 NC_011601.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 900539 artQ 7061404 artQ Escherichia coli O127:H6 str. E2348/69 arginine transporter permease subunit ArtQ YP_002328424.1 899823 R 574521 CDS YP_002328425.1 215485994 7061406 complement(900546..901277) 1 NC_011601.1 arginine transporter subunit 901277 artI 7061406 artI Escherichia coli O127:H6 str. E2348/69 arginine transporter subunit YP_002328425.1 900546 R 574521 CDS YP_002328426.1 215485995 7061402 complement(901295..902023) 1 NC_011601.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 902023 artP 7061402 artP Escherichia coli O127:H6 str. E2348/69 arginine transporter ATP-binding subunit YP_002328426.1 901295 R 574521 CDS YP_002328427.1 215485996 7061405 complement(902241..902756) 1 NC_011601.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; lipoprotein 902756 ybjP 7061405 ybjP Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002328427.1 902241 R 574521 CDS YP_002328428.1 215485997 7063326 902882..903205 1 NC_011601.1 hypothetical protein 903205 ybjQ 7063326 ybjQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328428.1 902882 D 574521 CDS YP_002328429.1 215485998 7063327 903202..904032 1 NC_011601.1 amidase 904032 ybjR 7063327 ybjR Escherichia coli O127:H6 str. E2348/69 amidase YP_002328429.1 903202 D 574521 CDS YP_002328430.1 215485999 7063328 complement(904029..905042) 1 NC_011601.1 NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain 905042 ybjS 7063328 ybjS Escherichia coli O127:H6 str. E2348/69 NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain YP_002328430.1 904029 R 574521 CDS YP_002328431.1 215486000 7063329 complement(905141..906571) 1 NC_011601.1 hypothetical protein 906571 ybjT 7063329 ybjT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328431.1 905141 R 574521 CDS YP_002328432.1 215486001 7063330 complement(906582..907583) 1 NC_011601.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase 907583 ltaE 7063330 ltaE Escherichia coli O127:H6 str. E2348/69 L-threonine aldolase YP_002328432.1 906582 R 574521 CDS YP_002328433.1 215486002 7065248 complement(907620..909338) 1 NC_011601.1 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 909338 poxB 7065248 poxB Escherichia coli O127:H6 str. E2348/69 pyruvate dehydrogenase YP_002328433.1 907620 R 574521 CDS YP_002328434.1 215486003 7061261 complement(909471..910439) 1 NC_011601.1 HCP oxidoreductase 910439 hcr 7061261 hcr Escherichia coli O127:H6 str. E2348/69 HCP oxidoreductase YP_002328434.1 909471 R 574521 CDS YP_002328435.1 215486004 7064283 complement(910451..912103) 1 NC_011601.1 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 912103 hcp 7064283 hcp Escherichia coli O127:H6 str. E2348/69 hydroxylamine reductase YP_002328435.1 910451 R 574521 CDS YP_002328436.1 215486005 7064282 complement(912247..913146) 1 NC_011601.1 transporter 913146 ybjE 7064282 ybjE Escherichia coli O127:H6 str. E2348/69 transporter YP_002328436.1 912247 R 574521 CDS YP_002328437.1 215486006 7063316 complement(913630..914325) 1 NC_011601.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 914325 aqpZ 7063316 aqpZ Escherichia coli O127:H6 str. E2348/69 aquaporin Z YP_002328437.1 913630 R 574521 CDS YP_002328438.1 215486007 7061355 914751..916409 1 NC_011601.1 hypothetical protein 916409 ybjD 7061355 ybjD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328438.1 914751 D 574521 CDS YP_002328439.1 215486008 7063315 complement(916406..917398) 1 NC_011601.1 hypothetical protein 917398 ybjX 7063315 ybjX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328439.1 916406 R 574521 CDS YP_002328440.1 215486009 7063331 917513..918628 1 NC_011601.1 confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 918628 macA 7063331 macA Escherichia coli O127:H6 str. E2348/69 macrolide transporter subunit MacA YP_002328440.1 917513 D 574521 CDS YP_002328441.1 215486010 7065265 918625..920571 1 NC_011601.1 with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 920571 macB 7065265 macB Escherichia coli O127:H6 str. E2348/69 macrolide transporter ATP-binding /permease YP_002328441.1 918625 D 574521 CDS YP_002328442.1 215486011 7065266 complement(920644..920868) 1 NC_011601.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 920868 cspD 7065266 cspD Escherichia coli O127:H6 str. E2348/69 stationary phase/starvation inducible regulatory protein CspD YP_002328442.1 920644 R 574521 CDS YP_002328443.1 215486012 7062862 921191..921511 1 NC_011601.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 921511 clpS 7062862 clpS Escherichia coli O127:H6 str. E2348/69 ATP-dependent Clp protease adaptor protein ClpS YP_002328443.1 921191 D 574521 CDS YP_002328444.1 215486013 7062811 921542..923818 1 NC_011601.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 923818 clpA 7062811 clpA Escherichia coli O127:H6 str. E2348/69 ATP-dependent Clp protease ATP-binding subunit YP_002328444.1 921542 D 574521 CDS YP_002328445.1 215486014 7062704 complement(924621..924839) 1 NC_011601.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 924839 infA 7062704 infA Escherichia coli O127:H6 str. E2348/69 translation initiation factor IF-1 YP_002328445.1 924621 R 574521 CDS YP_002328446.1 215486015 7063542 complement(925124..925828) 1 NC_011601.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 925828 aat 7063542 aat Escherichia coli O127:H6 str. E2348/69 leucyl/phenylalanyl-tRNA--protein transferase YP_002328446.1 925124 R 574521 CDS YP_002328447.1 215486016 7061178 complement(925870..927591) 1 NC_011601.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 927591 cydC 7061178 cydC Escherichia coli O127:H6 str. E2348/69 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_002328447.1 925870 R 574521 CDS YP_002328448.1 215486017 7065186 complement(927592..929358) 1 NC_011601.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 929358 cydD 7065186 cydD Escherichia coli O127:H6 str. E2348/69 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_002328448.1 927592 R 574521 CDS YP_002328449.1 215486018 7065187 complement(929481..930446) 1 NC_011601.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 930446 trxB 7065187 trxB Escherichia coli O127:H6 str. E2348/69 thioredoxin reductase YP_002328449.1 929481 R 574521 CDS YP_002328450.1 215486019 7062268 930991..931485 1 NC_011601.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 931485 lrp 7062268 lrp Escherichia coli O127:H6 str. E2348/69 leucine-responsive transcriptional regulator YP_002328450.1 930991 D 574521 CDS YP_002328451.1 215486020 7065246 931620..935726 1 NC_011601.1 DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 935726 ftsK 7065246 ftsK Escherichia coli O127:H6 str. E2348/69 DNA translocase FtsK YP_002328451.1 931620 D 574521 CDS YP_002328452.1 215486021 7061585 935882..936496 1 NC_011601.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 936496 lolA 7061585 lolA Escherichia coli O127:H6 str. E2348/69 outer-membrane lipoprotein carrier protein YP_002328452.1 935882 D 574521 CDS YP_002328453.1 215486022 7061554 936507..937850 1 NC_011601.1 recombination factor protein RarA 937850 rarA 7061554 rarA Escherichia coli O127:H6 str. E2348/69 recombination factor protein RarA YP_002328453.1 936507 D 574521 CDS YP_002328454.1 215486023 7063948 937941..939233 1 NC_011601.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 939233 serS 7063948 serS Escherichia coli O127:H6 str. E2348/69 seryl-tRNA synthetase YP_002328454.1 937941 D 574521 CDS YP_002328455.1 215486024 7065040 941927..942544 1 NC_011601.1 dimethyl sulfoxide reductase, anaerobic subunit B 942544 dmsB 7065040 dmsB Escherichia coli O127:H6 str. E2348/69 dimethyl sulfoxide reductase, anaerobic subunit B YP_002328455.1 941927 D 574521 CDS YP_002328456.1 215486025 7065041 942546..943409 1 NC_011601.1 dimethyl sulfoxide reductase, anaerobic subunit C 943409 dmsC 7065041 dmsC Escherichia coli O127:H6 str. E2348/69 dimethyl sulfoxide reductase, anaerobic subunit C YP_002328456.1 942546 D 574521 CDS YP_002328457.1 215486026 7063332 944302..945450 1 NC_011601.1 MFS family transporter protein 945450 ycaD 7063332 ycaD Escherichia coli O127:H6 str. E2348/69 MFS family transporter protein YP_002328457.1 944302 D 574521 CDS YP_002328458.1 215486027 7063333 complement(945547..946287) 1 NC_011601.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 946287 pflA 7063333 pflA Escherichia coli O127:H6 str. E2348/69 pyruvate formate lyase-activating enzyme 1 YP_002328458.1 945547 R 574521 CDS YP_002328459.1 215486028 7060708 complement(946479..948761) 1 NC_011601.1 pyruvate formate lyase I 948761 pflB 7060708 pflB Escherichia coli O127:H6 str. E2348/69 pyruvate formate lyase I YP_002328459.1 946479 R 574521 CDS YP_002328460.1 215486029 7060709 complement(948816..949673) 1 NC_011601.1 formate transporter 949673 focA 7060709 focA Escherichia coli O127:H6 str. E2348/69 formate transporter YP_002328460.1 948816 R 574521 CDS YP_002328461.1 215486030 7061937 complement(950079..951839) 1 NC_011601.1 hypothetical protein 951839 ycaO 7061937 ycaO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328461.1 950079 R 574521 CDS YP_002328462.1 215486031 7063336 951969..952661 1 NC_011601.1 hypothetical protein 952661 ycaP 7063336 ycaP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328462.1 951969 D 574521 CDS YP_002328463.1 215486032 7063337 952860..953948 1 NC_011601.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 953948 serC 7063337 serC Escherichia coli O127:H6 str. E2348/69 phosphoserine aminotransferase YP_002328463.1 952860 D 574521 CDS YP_002328464.1 215486033 7065368 954019..955302 1 NC_011601.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 955302 aroA 7065368 aroA Escherichia coli O127:H6 str. E2348/69 3-phosphoshikimate 1-carboxyvinyltransferase YP_002328464.1 954019 D 574521 CDS YP_002328465.1 215486034 7061389 955472..956236 1 NC_011601.1 peptidase with chaperone function 956236 ycaL 7061389 ycaL Escherichia coli O127:H6 str. E2348/69 peptidase with chaperone function YP_002328465.1 955472 D 574521 CDS YP_002328466.1 215486035 7063335 956409..957092 1 NC_011601.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 957092 cmk 7063335 cmk Escherichia coli O127:H6 str. E2348/69 cytidylate kinase YP_002328466.1 956409 D 574521 CDS YP_002328467.1 215486036 7062814 957203..958876 1 NC_011601.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 958876 rpsA 7062814 rpsA Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S1 YP_002328467.1 957203 D 574521 CDS YP_002328468.1 215486037 7061873 959036..959320 1 NC_011601.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 959320 ihfB 7061873 ihfB Escherichia coli O127:H6 str. E2348/69 integration host factor subunit beta YP_002328468.1 959036 D 574521 CDS YP_002328469.1 215486038 7063521 959526..961790 1 NC_011601.1 hypothetical protein 961790 ycaI 7063521 ycaI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328469.1 959526 D 574521 CDS YP_002328470.1 215486039 7063334 961827..963575 1 NC_011601.1 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding protein/permease 963575 msbA 7063334 msbA Escherichia coli O127:H6 str. E2348/69 lipid transporter ATP-binding protein/permease YP_002328470.1 961827 D 574521 CDS YP_002328471.1 215486040 7060871 963572..964558 1 NC_011601.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 964558 lpxK 7060871 lpxK Escherichia coli O127:H6 str. E2348/69 tetraacyldisaccharide 4'-kinase YP_002328471.1 963572 D 574521 CDS YP_002328472.1 215486041 7061577 964595..965827 1 NC_011601.1 hypothetical protein 965827 ycaQ 7061577 ycaQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328472.1 964595 D 574521 CDS YP_002328473.1 215486042 7063338 965879..966061 1 NC_011601.1 hypothetical protein 966061 ycaR 7063338 ycaR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328473.1 965879 D 574521 CDS YP_002328474.1 215486043 7063339 966058..966804 1 NC_011601.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 966804 kdsB 7063339 kdsB Escherichia coli O127:H6 str. E2348/69 3-deoxy-manno-octulosonate cytidylyltransferase YP_002328474.1 966058 D 574521 CDS YP_002328475.1 215486044 7063579 966958..967851 1 NC_011601.1 hypothetical protein 967851 ycbJ 7063579 ycbJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328475.1 966958 D 574521 CDS YP_002328476.1 215486045 7061419 complement(967828..968607) 1 NC_011601.1 hypothetical protein 968607 ycbC 7061419 ycbC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328476.1 967828 R 574521 CDS YP_002328477.1 215486046 7063341 968743..969528 1 NC_011601.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA 969528 smtA 7063341 smtA Escherichia coli O127:H6 str. E2348/69 metallothionein SmtA YP_002328477.1 968743 D 574521 CDS YP_002328478.1 215486047 7062731 969525..970847 1 NC_011601.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 970847 mukF 7062731 mukF Escherichia coli O127:H6 str. E2348/69 condesin subunit F YP_002328478.1 969525 D 574521 CDS YP_002328479.1 215486048 7060886 970828..971532 1 NC_011601.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 971532 mukE 7060886 mukE Escherichia coli O127:H6 str. E2348/69 condesin subunit E YP_002328479.1 970828 D 574521 CDS YP_002328480.1 215486049 7060885 971532..975992 1 NC_011601.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 975992 mukB 7060885 mukB Escherichia coli O127:H6 str. E2348/69 cell division protein MukB YP_002328480.1 971532 D 574521 CDS YP_002328481.1 215486050 7060884 976253..978100 1 NC_011601.1 hypothetical protein 978100 ycbB 7060884 ycbB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328481.1 976253 D 574521 CDS YP_002328482.1 215486051 7063340 978281..978829 1 NC_011601.1 hypothetical protein 978829 ycbK 7063340 ycbK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328482.1 978281 D 574521 CDS YP_002328483.1 215486052 7061420 978856..979503 1 NC_011601.1 metal-binding enzyme 979503 ycbL 7061420 ycbL Escherichia coli O127:H6 str. E2348/69 metal-binding enzyme YP_002328483.1 978856 D 574521 CDS YP_002328484.1 215486053 7061421 complement(979553..980743) 1 NC_011601.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 980743 aspC 7061421 aspC Escherichia coli O127:H6 str. E2348/69 aromatic amino acid aminotransferase YP_002328484.1 979553 R 574521 CDS YP_002328485.1 215486054 7062459 complement(980927..981997) 1 NC_011601.1 outer membrane porin F; 1a; Ia; b; outer membrane protein F 981997 ompF 7062459 ompF Escherichia coli O127:H6 str. E2348/69 outer membrane protein F YP_002328485.1 980927 R 574521 CDS YP_002328486.1 215486055 7062875 complement(982600..984000) 1 NC_011601.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 984000 asnC 7062875 asnC Escherichia coli O127:H6 str. E2348/69 asparaginyl-tRNA synthetase YP_002328486.1 982600 R 574521 CDS YP_002328487.1 215486056 7061414 complement(984169..985371) 1 NC_011601.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 985371 pncB 7061414 pncB Escherichia coli O127:H6 str. E2348/69 nicotinate phosphoribosyltransferase YP_002328487.1 984169 R 574521 CDS YP_002328488.1 215486057 7060762 985637..988249 1 NC_011601.1 aminopeptidase 988249 pepN 7060762 pepN Escherichia coli O127:H6 str. E2348/69 aminopeptidase YP_002328488.1 985637 D 574521 CDS YP_002328489.1 215486058 7060702 complement(988455..989222) 1 NC_011601.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit 989222 ssuB 7060702 ssuB Escherichia coli O127:H6 str. E2348/69 aliphatic sulfonates transport ATP-binding subunit YP_002328489.1 988455 R 574521 CDS YP_002328490.1 215486059 7062771 complement(989219..990010) 1 NC_011601.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease 990010 ssuC 7062771 ssuC Escherichia coli O127:H6 str. E2348/69 alkanesulfonate transporter permease YP_002328490.1 989219 R 574521 CDS YP_002328491.1 215486060 7062772 complement(990022..991167) 1 NC_011601.1 catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase 991167 ssuD 7062772 ssuD Escherichia coli O127:H6 str. E2348/69 alkanesulfonate monooxygenase YP_002328491.1 990022 R 574521 CDS YP_002328492.1 215486061 7062773 complement(991164..992123) 1 NC_011601.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 992123 ssuA 7062773 ssuA Escherichia coli O127:H6 str. E2348/69 alkanesulfonate transporter substrate-binding subunit YP_002328492.1 991164 R 574521 CDS YP_002328493.1 215486062 7062770 complement(992116..992691) 1 NC_011601.1 NAD(P)H-dependent FMN reductase 992691 ssuE 7062770 ssuE Escherichia coli O127:H6 str. E2348/69 NAD(P)H-dependent FMN reductase YP_002328493.1 992116 R 574521 CDS YP_002328494.1 215486063 7062774 992928..993938 1 NC_011601.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 993938 pyrD 7062774 pyrD Escherichia coli O127:H6 str. E2348/69 dihydroorotate dehydrogenase 2 YP_002328494.1 992928 D 574521 CDS YP_002328495.1 215486064 7063931 994112..994654 1 NC_011601.1 hypothetical protein 994654 ycbW 7063931 ycbW Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328495.1 994112 D 574521 CDS YP_002328496.1 215486065 7061422 complement(994651..995760) 1 NC_011601.1 2Fe-2S cluster-containing protein 995760 ycbX 7061422 ycbX Escherichia coli O127:H6 str. E2348/69 2Fe-2S cluster-containing protein YP_002328496.1 994651 R 574521 CDS YP_002328497.1 215486066 7061423 995858..997966 1 NC_011601.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 997966 rlmL 7061423 rlmL Escherichia coli O127:H6 str. E2348/69 23S rRNA m(2)G2445 methyltransferase YP_002328497.1 995858 D 574521 CDS YP_002328498.1 215486067 7060835 997978..999885 1 NC_011601.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 999885 uup 7060835 uup Escherichia coli O127:H6 str. E2348/69 ABC transporter ATPase YP_002328498.1 997978 D 574521 CDS YP_002328499.1 215486068 7062339 1000015..1001268 1 NC_011601.1 paraquat-inducible membrane protein A 1001268 pqiA 7062339 pqiA Escherichia coli O127:H6 str. E2348/69 paraquat-inducible membrane protein A YP_002328499.1 1000015 D 574521 CDS YP_002328500.1 215486069 7061280 1001273..1002913 1 NC_011601.1 paraquat-inducible protein B 1002913 pqiB 7061280 pqiB Escherichia coli O127:H6 str. E2348/69 paraquat-inducible protein B YP_002328500.1 1001273 D 574521 CDS YP_002328501.1 215486070 7061281 1002910..1003473 1 NC_011601.1 hypothetical protein 1003473 ymbA 7061281 ymbA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328501.1 1002910 D 574521 CDS YP_002328502.1 215486071 7062020 1003729..1003896 1 NC_011601.1 ribosome modulation factor 1003896 rmf 7062020 rmf Escherichia coli O127:H6 str. E2348/69 ribosome modulation factor YP_002328502.1 1003729 D 574521 CDS YP_002328503.1 215486072 7060844 complement(1003966..1004484) 1 NC_011601.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase 1004484 fabA 7060844 fabA Escherichia coli O127:H6 str. E2348/69 3-hydroxydecanoyl-ACP dehydratase YP_002328503.1 1003966 R 574521 CDS YP_002328504.1 215486073 7062062 complement(1004553..1006313) 1 NC_011601.1 peptidase 1006313 ycbZ 7062062 ycbZ Escherichia coli O127:H6 str. E2348/69 peptidase YP_002328504.1 1004553 R 574521 CDS YP_002328505.1 215486074 7061424 1006499..1006951 1 NC_011601.1 hypothetical protein 1006951 ycbG 7061424 ycbG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328505.1 1006499 D 574521 CDS YP_002328506.1 215486075 7063342 complement(1007029..1008069) 1 NC_011601.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A 1008069 ompA 7063342 ompA Escherichia coli O127:H6 str. E2348/69 outer membrane protein A YP_002328506.1 1007029 R 574521 CDS YP_002328507.1 215486076 7062873 complement(1008425..1008934) 1 NC_011601.1 SOS cell division inhibitor 1008934 sulA 7062873 sulA Escherichia coli O127:H6 str. E2348/69 SOS cell division inhibitor YP_002328507.1 1008425 R 574521 CDS YP_002328508.1 215486077 7061743 1009152..1009781 1 NC_011601.1 hypothetical protein 1009781 yccR 7061743 yccR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328508.1 1009152 D 574521 CDS YP_002328509.1 215486078 7061430 complement(1009744..1011897) 1 NC_011601.1 hypothetical protein 1011897 yccS 7061430 yccS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328509.1 1009744 R 574521 CDS YP_002328510.1 215486079 7061431 complement(1011916..1012362) 1 NC_011601.1 hypothetical protein 1012362 yccF 7061431 yccF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328510.1 1011916 R 574521 CDS YP_002328511.1 215486080 7061426 1012485..1014539 1 NC_011601.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1014539 helD 7061426 helD Escherichia coli O127:H6 str. E2348/69 DNA helicase IV YP_002328511.1 1012485 D 574521 CDS YP_002328512.1 215486081 7064290 complement(1014571..1015029) 1 NC_011601.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 1015029 mgsA 7064290 mgsA Escherichia coli O127:H6 str. E2348/69 methylglyoxal synthase YP_002328512.1 1014571 R 574521 CDS YP_002328513.1 215486082 7063781 complement(1015125..1015787) 1 NC_011601.1 hypothetical protein 1015787 yccT 7063781 yccT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328513.1 1015125 R 574521 CDS YP_002328514.1 215486083 7061432 1015960..1016373 1 NC_011601.1 CoA-binding protein with NAD(P)-binding Rossmann-fold domain 1016373 yccU 7061432 yccU Escherichia coli O127:H6 str. E2348/69 CoA-binding protein with NAD(P)-binding Rossmann-fold domain YP_002328514.1 1015960 D 574521 CDS YP_002328515.1 215486084 7061433 complement(1016418..1016735) 1 NC_011601.1 heat shock protein HspQ 1016735 hspQ 7061433 hspQ Escherichia coli O127:H6 str. E2348/69 heat shock protein HspQ YP_002328515.1 1016418 R 574521 CDS YP_002328516.1 215486085 7062187 complement(1016793..1017983) 1 NC_011601.1 methyltransferase 1017983 yccW 7062187 yccW Escherichia coli O127:H6 str. E2348/69 methyltransferase YP_002328516.1 1016793 R 574521 CDS YP_002328517.1 215486086 7061434 1018078..1018356 1 NC_011601.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1018356 yccX 7061434 yccX Escherichia coli O127:H6 str. E2348/69 acylphosphatase YP_002328517.1 1018078 D 574521 CDS YP_002328518.1 215486087 7061435 complement(1018353..1018682) 1 NC_011601.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 1018682 yccK 7061435 yccK Escherichia coli O127:H6 str. E2348/69 sulfur transfer protein TusE YP_002328518.1 1018353 R 574521 CDS YP_002328519.1 215486088 7061428 complement(1018774..1019433) 1 NC_011601.1 hypothetical protein 1019433 yccA 7061428 yccA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328519.1 1018774 R 574521 CDS YP_002328520.1 215486089 7065370 1020154..1021272 1 NC_011601.1 hydrogenase 1, small subunit 1021272 hyaA 7065370 hyaA Escherichia coli O127:H6 str. E2348/69 hydrogenase 1, small subunit YP_002328520.1 1020154 D 574521 CDS YP_002328521.1 215486090 7062195 1021269..1023062 1 NC_011601.1 involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1023062 hyaB 7062195 hyaB Escherichia coli O127:H6 str. E2348/69 hydrogenase 1 large subunit YP_002328521.1 1021269 D 574521 CDS YP_002328522.1 215486091 7062196 1023081..1023788 1 NC_011601.1 hydrogenase 1 b-type cytochrome subunit 1023788 hyaC 7062196 hyaC Escherichia coli O127:H6 str. E2348/69 hydrogenase 1 b-type cytochrome subunit YP_002328522.1 1023081 D 574521 CDS YP_002328523.1 215486092 7062197 1023785..1024372 1 NC_011601.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1024372 hyaD 7062197 hyaD Escherichia coli O127:H6 str. E2348/69 hydrogenase 1 maturation protease YP_002328523.1 1023785 D 574521 CDS YP_002328524.1 215486093 7062198 1024369..1024767 1 NC_011601.1 involved in processing hydrogenases HyaA and HyaB; hydrogenase-1 operon protein HyaE 1024767 hyaE 7062198 hyaE Escherichia coli O127:H6 str. E2348/69 hydrogenase-1 operon protein HyaE YP_002328524.1 1024369 D 574521 CDS YP_002328525.1 215486094 7062199 1024764..1025621 1 NC_011601.1 HyaF protein involved in nickel incorporation into hydrogenase-1 proteins 1025621 hyaF 7062199 hyaF Escherichia coli O127:H6 str. E2348/69 HyaF protein involved in nickel incorporation into hydrogenase-1 proteins YP_002328525.1 1024764 D 574521 CDS YP_002328526.1 215486095 7062200 1025755..1027299 1 NC_011601.1 cytochrome bd-II oxidase subunit I 1027299 appC 7062200 appC Escherichia coli O127:H6 str. E2348/69 cytochrome bd-II oxidase subunit I YP_002328526.1 1025755 D 574521 CDS YP_002328527.1 215486096 7061353 1027311..1028447 1 NC_011601.1 cytochrome bd-II oxidase subunit II 1028447 appB 7061353 appB Escherichia coli O127:H6 str. E2348/69 cytochrome bd-II oxidase subunit II YP_002328527.1 1027311 D 574521 CDS YP_002328528.1 215486097 7061352 1028632..1029930 1 NC_011601.1 phosphoanhydride phosphorylase 1029930 appA 7061352 appA Escherichia coli O127:H6 str. E2348/69 phosphoanhydride phosphorylase YP_002328528.1 1028632 D 574521 CDS YP_002328529.1 215486098 7061351 complement(1030051..1032231) 1 NC_011601.1 cryptic autophosphorylating protein tyrosine kinase Etk 1032231 etk 7061351 etk Escherichia coli O127:H6 str. E2348/69 cryptic autophosphorylating protein tyrosine kinase Etk YP_002328529.1 1030051 R 574521 CDS YP_002328530.1 215486099 7063885 complement(1032251..1032697) 1 NC_011601.1 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase 1032697 etp 7063885 etp Escherichia coli O127:H6 str. E2348/69 phosphotyrosine-protein phosphatase YP_002328530.1 1032251 R 574521 CDS YP_002328531.1 215486100 7063886 complement(1032685..1033824) 1 NC_011601.1 exopolysaccharide export protein 1033824 gfcE 7063886 gfcE Escherichia coli O127:H6 str. E2348/69 exopolysaccharide export protein YP_002328531.1 1032685 R 574521 CDS YP_002328532.1 215486101 7061652 complement(1033870..1035966) 1 NC_011601.1 hypothetical protein 1035966 gfcD 7061652 gfcD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328532.1 1033870 R 574521 CDS YP_002328533.1 215486102 7061651 complement(1035966..1036712) 1 NC_011601.1 hypothetical protein 1036712 gfcC 7061651 gfcC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328533.1 1035966 R 574521 CDS YP_002328534.1 215486103 7061650 complement(1036709..1037353) 1 NC_011601.1 outer membrane lipoprotein 1037353 gfcB 7061650 gfcB Escherichia coli O127:H6 str. E2348/69 outer membrane lipoprotein YP_002328534.1 1036709 R 574521 CDS YP_002328535.1 215486104 7061649 complement(1037461..1037766) 1 NC_011601.1 hypothetical protein 1037766 gfcA 7061649 gfcA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328535.1 1037461 R 574521 CDS YP_002328536.1 215486105 7061648 complement(1038208..1038420) 1 NC_011601.1 stress protein, member of the CspA-family 1038420 cspH 7061648 cspH Escherichia coli O127:H6 str. E2348/69 stress protein, member of the CspA-family YP_002328536.1 1038208 R 574521 CDS YP_002328537.1 215486106 7062865 1038706..1038918 1 NC_011601.1 cold shock protein CspG 1038918 cspG 7062865 cspG Escherichia coli O127:H6 str. E2348/69 cold shock protein CspG YP_002328537.1 1038706 D 574521 CDS YP_002328538.1 215486107 7062864 1039092..1039322 1 NC_011601.1 cold shock gene 1039322 ymcE 7062864 ymcE Escherichia coli O127:H6 str. E2348/69 cold shock gene YP_002328538.1 1039092 D 574521 CDS YP_002328539.1 215486108 7062021 1039312..1039485 1 NC_011601.1 regulator of phosphatidylethanolamine synthesis 1039485 gnsA 7062021 gnsA Escherichia coli O127:H6 str. E2348/69 regulator of phosphatidylethanolamine synthesis YP_002328539.1 1039312 D 574521 CDS YP_002328540.1 215486109 7061735 complement(1039534..1040607) 1 NC_011601.1 (4Fe-4S)-binding protein 1040607 yccM 7061735 yccM Escherichia coli O127:H6 str. E2348/69 (4Fe-4S)-binding protein YP_002328540.1 1039534 R 574521 CDS YP_002328541.1 215486110 7061429 complement(1040690..1043422) 1 NC_011601.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS 1043422 torS 7061429 torS Escherichia coli O127:H6 str. E2348/69 hybrid sensory histidine kinase TorS YP_002328541.1 1040690 R 574521 CDS YP_002328542.1 215486111 7061168 complement(1043517..1044590) 1 NC_011601.1 integrase 1044590 7061168 E2348C_0979 Escherichia coli O127:H6 str. E2348/69 integrase YP_002328542.1 1043517 R 574521 CDS YP_002328543.1 215486112 7061034 complement(1044568..1044786) 1 NC_011601.1 excisionase 1044786 7061034 E2348C_0980 Escherichia coli O127:H6 str. E2348/69 excisionase YP_002328543.1 1044568 R 574521 CDS YP_002328544.1 215486113 7061035 complement(1044826..1044993) 1 NC_011601.1 hypothetical protein 1044993 7061035 E2348C_0981 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328544.1 1044826 R 574521 CDS YP_002328545.1 215486114 7061036 complement(1045082..1045363) 1 NC_011601.1 hypothetical protein 1045363 7061036 E2348C_0982 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328545.1 1045082 R 574521 CDS YP_002328546.1 215486115 7061037 complement(1045566..1046234) 1 NC_011601.1 hypothetical protein 1046234 7061037 E2348C_0983 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328546.1 1045566 R 574521 CDS YP_002328547.1 215486116 7061038 complement(1046231..1046794) 1 NC_011601.1 hypothetical protein 1046794 7061038 E2348C_0984 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328547.1 1046231 R 574521 CDS YP_002328548.1 215486117 7061039 complement(1046966..1047259) 1 NC_011601.1 anti-RecBCD protein 1047259 7061039 E2348C_0985 Escherichia coli O127:H6 str. E2348/69 anti-RecBCD protein YP_002328548.1 1046966 R 574521 CDS YP_002328549.1 215486118 7061040 complement(1047273..1047779) 1 NC_011601.1 single-stranded DNA-binding protein 1047779 7061040 E2348C_0986 Escherichia coli O127:H6 str. E2348/69 single-stranded DNA-binding protein YP_002328549.1 1047273 R 574521 CDS YP_002328550.1 215486119 7061041 complement(1047780..1048487) 1 NC_011601.1 recombination protein 1048487 7061041 E2348C_0987 Escherichia coli O127:H6 str. E2348/69 recombination protein YP_002328550.1 1047780 R 574521 CDS YP_002328551.1 215486120 7061042 complement(1048496..1048666) 1 NC_011601.1 hypothetical protein 1048666 7061042 E2348C_0988 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328551.1 1048496 R 574521 CDS YP_002328552.1 215486121 7061043 complement(1048587..1048745) 1 NC_011601.1 hypothetical protein 1048745 7061043 E2348C_0989 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328552.1 1048587 R 574521 CDS YP_002328553.1 215486122 7061044 complement(1048742..1048894) 1 NC_011601.1 host killing protein 1048894 7061044 E2348C_0990 Escherichia coli O127:H6 str. E2348/69 host killing protein YP_002328553.1 1048742 R 574521 CDS YP_002328554.1 215486123 7061045 complement(1048879..1049013) 1 NC_011601.1 reguratory protein 1049013 7061045 E2348C_0991 Escherichia coli O127:H6 str. E2348/69 reguratory protein YP_002328554.1 1048879 R 574521 CDS YP_002328555.1 215486124 7061046 complement(1049089..1049457) 1 NC_011601.1 single-stranded DNA binding protein 1049457 7061046 E2348C_0992 Escherichia coli O127:H6 str. E2348/69 single-stranded DNA binding protein YP_002328555.1 1049089 R 574521 CDS YP_002328556.1 215486125 7061047 complement(1049608..1050078) 1 NC_011601.1 hypothetical protein 1050078 7061047 E2348C_0993 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328556.1 1049608 R 574521 CDS YP_002328557.1 215486126 7061048 complement(1050137..1050409) 1 NC_011601.1 antitermination protein 1050409 7061048 E2348C_0994 Escherichia coli O127:H6 str. E2348/69 antitermination protein YP_002328557.1 1050137 R 574521 CDS YP_002328558.1 215486127 7061049 complement(1050848..1051690) 1 NC_011601.1 DNA-damage-inducible protein 1051690 7061049 E2348C_0995 Escherichia coli O127:H6 str. E2348/69 DNA-damage-inducible protein YP_002328558.1 1050848 R 574521 CDS YP_002328559.1 215486128 7061050 complement(1051771..1052424) 1 NC_011601.1 repressor protein 1052424 7061050 E2348C_0996 Escherichia coli O127:H6 str. E2348/69 repressor protein YP_002328559.1 1051771 R 574521 CDS YP_002328560.1 215486129 7061051 1052541..1052756 1 NC_011601.1 antirepressor protein 1052756 7061051 E2348C_0997 Escherichia coli O127:H6 str. E2348/69 antirepressor protein YP_002328560.1 1052541 D 574521 CDS YP_002328561.1 215486130 7061052 1052898..1053194 1 NC_011601.1 regulatory protein 1053194 7061052 E2348C_0998 Escherichia coli O127:H6 str. E2348/69 regulatory protein YP_002328561.1 1052898 D 574521 CDS YP_002328562.1 215486131 7061053 1053227..1054126 1 NC_011601.1 replication protein 1054126 7061053 E2348C_0999 Escherichia coli O127:H6 str. E2348/69 replication protein YP_002328562.1 1053227 D 574521 CDS YP_002328563.1 215486132 7061054 1054123..1054824 1 NC_011601.1 replication protein 1054824 7061054 E2348C_1000 Escherichia coli O127:H6 str. E2348/69 replication protein YP_002328563.1 1054123 D 574521 CDS YP_002328564.1 215486133 7061055 1054821..1055111 1 NC_011601.1 exclusion protein 1055111 7061055 E2348C_1001 Escherichia coli O127:H6 str. E2348/69 exclusion protein YP_002328564.1 1054821 D 574521 CDS YP_002328565.1 215486134 7061056 1055184..1055510 1 NC_011601.1 hypothetical protein 1055510 7061056 E2348C_1002 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328565.1 1055184 D 574521 CDS YP_002328566.1 215486135 7061057 1055533..1055979 1 NC_011601.1 protein NinB 1055979 7061057 E2348C_1003 Escherichia coli O127:H6 str. E2348/69 protein NinB YP_002328566.1 1055533 D 574521 CDS YP_002328567.1 215486136 7061058 1055976..1056503 1 NC_011601.1 DNA methylase 1056503 7061058 E2348C_1004 Escherichia coli O127:H6 str. E2348/69 DNA methylase YP_002328567.1 1055976 D 574521 CDS YP_002328568.1 215486137 7061059 1056500..1056682 1 NC_011601.1 protein NinE 1056682 7061059 E2348C_1005 Escherichia coli O127:H6 str. E2348/69 protein NinE YP_002328568.1 1056500 D 574521 CDS YP_002328569.1 215486138 7061060 1056679..1056849 1 NC_011601.1 protein NinF 1056849 7061060 E2348C_1006 Escherichia coli O127:H6 str. E2348/69 protein NinF YP_002328569.1 1056679 D 574521 CDS YP_002328570.1 215486139 7061061 1056842..1057564 1 NC_011601.1 DNA-binding protein 1057564 7061061 E2348C_1007 Escherichia coli O127:H6 str. E2348/69 DNA-binding protein YP_002328570.1 1056842 D 574521 CDS YP_002328571.1 215486140 7061062 1057564..1057854 1 NC_011601.1 hypothetical protein 1057854 7061062 E2348C_1008 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328571.1 1057564 D 574521 CDS YP_002328572.1 215486141 7061063 1057851..1058213 1 NC_011601.1 crossover junction endodeoxyribonuclease 1058213 7061063 E2348C_1009 Escherichia coli O127:H6 str. E2348/69 crossover junction endodeoxyribonuclease YP_002328572.1 1057851 D 574521 CDS YP_002328573.1 215486142 7061064 1058210..1058344 1 NC_011601.1 hypothetical protein 1058344 7061064 E2348C_1010 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328573.1 1058210 D 574521 CDS YP_002328574.1 215486143 7061065 1058356..1058979 1 NC_011601.1 late gene regulator 1058979 7061065 E2348C_1011 Escherichia coli O127:H6 str. E2348/69 late gene regulator YP_002328574.1 1058356 D 574521 CDS YP_002328575.1 215486144 7061066 1059259..1059975 1 NC_011601.1 membrane protein 1059975 7061066 E2348C_1012 Escherichia coli O127:H6 str. E2348/69 membrane protein YP_002328575.1 1059259 D 574521 CDS YP_002328576.1 215486145 7061067 complement(1060300..1060698) 1 NC_011601.1 hypothetical protein 1060698 7061067 E2348C_1013 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328576.1 1060300 R 574521 CDS YP_002328577.1 215486146 7061068 1060841..1061056 1 NC_011601.1 holin protein 1061056 7061068 E2348C_1014 Escherichia coli O127:H6 str. E2348/69 holin protein YP_002328577.1 1060841 D 574521 CDS YP_002328578.1 215486147 7061069 1061056..1061553 1 NC_011601.1 endolysin 1061553 7061069 E2348C_1015 Escherichia coli O127:H6 str. E2348/69 endolysin YP_002328578.1 1061056 D 574521 CDS YP_002328579.1 215486148 7061070 1061550..1062017 1 NC_011601.1 endopeptidase 1062017 7061070 E2348C_1016 Escherichia coli O127:H6 str. E2348/69 endopeptidase YP_002328579.1 1061550 D 574521 CDS YP_002328580.1 215486149 7061071 1061770..1061976 1 NC_011601.1 lipoprotein precursor 1061976 7061071 E2348C_1017 Escherichia coli O127:H6 str. E2348/69 lipoprotein precursor YP_002328580.1 1061770 D 574521 CDS YP_002328581.1 215486150 7061072 1062216..1062740 1 NC_011601.1 hypothetical protein 1062740 7061072 E2348C_1018 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328581.1 1062216 D 574521 CDS YP_002328582.1 215486151 7061073 1063348..1063842 1 NC_011601.1 hypothetical protein 1063842 7061073 E2348C_1019 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328582.1 1063348 D 574521 CDS YP_002328583.1 215486152 7061074 1063842..1065944 1 NC_011601.1 terminase large subunit 1065944 7061074 E2348C_1020 Escherichia coli O127:H6 str. E2348/69 terminase large subunit YP_002328583.1 1063842 D 574521 CDS YP_002328584.1 215486153 7061075 1065941..1066153 1 NC_011601.1 hypothetical protein 1066153 7061075 E2348C_1021 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328584.1 1065941 D 574521 CDS YP_002328585.1 215486154 7061076 1066153..1067661 1 NC_011601.1 portal protein 1067661 7061076 E2348C_1022 Escherichia coli O127:H6 str. E2348/69 portal protein YP_002328585.1 1066153 D 574521 CDS YP_002328586.1 215486155 7061077 1067543..1069633 1 NC_011601.1 protease/scaffold protein 1069633 7061077 E2348C_1023 Escherichia coli O127:H6 str. E2348/69 protease/scaffold protein YP_002328586.1 1067543 D 574521 CDS YP_002328587.1 215486156 7061078 1069720..1070043 1 NC_011601.1 hypothetical protein 1070043 7061078 E2348C_1024 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328587.1 1069720 D 574521 CDS YP_002328588.1 215486157 7061079 1070036..1070311 1 NC_011601.1 hypothetical protein 1070311 7061079 E2348C_1025 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328588.1 1070036 D 574521 CDS YP_002328589.1 215486158 7061080 1070323..1070901 1 NC_011601.1 minor tail protein 1070901 7061080 E2348C_1026 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328589.1 1070323 D 574521 CDS YP_002328590.1 215486159 7061081 1070898..1071299 1 NC_011601.1 minor tail protein 1071299 7061081 E2348C_1027 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328590.1 1070898 D 574521 CDS YP_002328591.1 215486160 7061082 1071310..1072053 1 NC_011601.1 major tail protein 1072053 7061082 E2348C_1028 Escherichia coli O127:H6 str. E2348/69 major tail protein YP_002328591.1 1071310 D 574521 CDS YP_002328592.1 215486161 7061083 1072114..1072500 1 NC_011601.1 minor tail protein 1072500 7061083 E2348C_1029 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328592.1 1072114 D 574521 CDS YP_002328593.1 215486162 7061084 1072509..1072838 1 NC_011601.1 minor tail protein 1072838 7061084 E2348C_1030 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328593.1 1072509 D 574521 CDS YP_002328594.1 215486163 7061086 1075865..1076194 1 NC_011601.1 minor tail protein 1076194 7061086 E2348C_1032 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328594.1 1075865 D 574521 CDS YP_002328595.1 215486164 7061087 1076204..1076902 1 NC_011601.1 minor tail protein 1076902 7061087 E2348C_1033 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328595.1 1076204 D 574521 CDS YP_002328596.1 215486165 7061088 1076907..1077650 1 NC_011601.1 tail assembly protein 1077650 7061088 E2348C_1034 Escherichia coli O127:H6 str. E2348/69 tail assembly protein YP_002328596.1 1076907 D 574521 CDS YP_002328597.1 215486166 7061089 1077548..1078195 1 NC_011601.1 tail assembly protein 1078195 7061089 E2348C_1035 Escherichia coli O127:H6 str. E2348/69 tail assembly protein YP_002328597.1 1077548 D 574521 CDS YP_002328598.1 215486167 7061091 1082040..1082639 1 NC_011601.1 outer membrane precursor Lom 1082639 7061091 E2348C_1037 Escherichia coli O127:H6 str. E2348/69 outer membrane precursor Lom YP_002328598.1 1082040 D 574521 CDS YP_002328599.1 215486168 7061092 1082704..1084017 1 NC_011601.1 side tail fiber protein 1084017 7061092 E2348C_1038 Escherichia coli O127:H6 str. E2348/69 side tail fiber protein YP_002328599.1 1082704 D 574521 CDS YP_002328600.1 215486169 7061093 1084019..1084288 1 NC_011601.1 hypothetical protein 1084288 7061093 E2348C_1039 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328600.1 1084019 D 574521 CDS YP_002328601.1 215486170 7061094 1084403..1084981 1 NC_011601.1 T3SS secreted effector NleI/NleG-like protein 1084981 7061094 E2348C_1040 Escherichia coli O127:H6 str. E2348/69 T3SS secreted effector NleI/NleG-like protein YP_002328601.1 1084403 D 574521 CDS YP_002328602.1 215486171 7061095 1085343..1086323 1 NC_011601.1 T3SS effector-like protein NleB-like protein 1086323 7061095 E2348C_1041 Escherichia coli O127:H6 str. E2348/69 T3SS effector-like protein NleB-like protein YP_002328602.1 1085343 D 574521 CDS YP_002328603.1 215486172 7061096 1086384..1087376 1 NC_011601.1 T3SS secreted effector NleC-like protein 1087376 7061096 E2348C_1042 Escherichia coli O127:H6 str. E2348/69 T3SS secreted effector NleC-like protein YP_002328603.1 1086384 D 574521 CDS YP_002328604.1 215486173 7064968 1087845..1088543 1 NC_011601.1 T3SS secreted effector NleD-like protein 1088543 7064968 E2348C_1044 Escherichia coli O127:H6 str. E2348/69 T3SS secreted effector NleD-like protein YP_002328604.1 1087845 D 574521 CDS YP_002328605.1 215486174 7064684 1089018..1090046 1 NC_011601.1 periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1090046 torT 7064684 torT Escherichia coli O127:H6 str. E2348/69 TMAO reductase system periplasmic protein TorT YP_002328605.1 1089018 D 574521 CDS YP_002328606.1 215486175 7062226 complement(1090019..1090711) 1 NC_011601.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 1090711 torR 7062226 torR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator TorR YP_002328606.1 1090019 R 574521 CDS YP_002328607.1 215486176 7062224 1090841..1092013 1 NC_011601.1 trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit 1092013 torC 7062224 torC Escherichia coli O127:H6 str. E2348/69 trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit YP_002328607.1 1090841 D 574521 CDS YP_002328608.1 215486177 7062221 1092013..1094559 1 NC_011601.1 trimethylamine N-oxide (TMAO) reductase I, catalytic subunit 1094559 torA 7062221 torA Escherichia coli O127:H6 str. E2348/69 trimethylamine N-oxide (TMAO) reductase I, catalytic subunit YP_002328608.1 1092013 D 574521 CDS YP_002328609.1 215486178 7062220 1094556..1095155 1 NC_011601.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 1095155 torD 7062220 torD Escherichia coli O127:H6 str. E2348/69 chaperone protein TorD YP_002328609.1 1094556 D 574521 CDS YP_002328610.1 215486179 7062222 complement(1095511..1095816) 1 NC_011601.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 1095816 cbpM 7062222 cbpM Escherichia coli O127:H6 str. E2348/69 chaperone-modulator protein CbpM YP_002328610.1 1095511 R 574521 CDS YP_002328611.1 215486180 7064328 complement(1095816..1096736) 1 NC_011601.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 1096736 cbpA 7064328 cbpA Escherichia coli O127:H6 str. E2348/69 curved DNA-binding protein CbpA YP_002328611.1 1095816 R 574521 CDS YP_002328612.1 215486181 7064327 1097271..1098512 1 NC_011601.1 glucose-1-phosphatase/inositol phosphatase 1098512 agp 7064327 agp Escherichia coli O127:H6 str. E2348/69 glucose-1-phosphatase/inositol phosphatase YP_002328612.1 1097271 D 574521 CDS YP_002328613.1 215486182 7064969 1098701..1100074 1 NC_011601.1 transposase of ISEc13 1100074 7064969 E2348C_1053 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002328613.1 1098701 D 574521 CDS YP_002328614.1 215486183 7064685 complement(1100109..1100336) 1 NC_011601.1 hypothetical protein 1100336 yccJ 7064685 yccJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328614.1 1100109 R 574521 CDS YP_002328615.1 215486184 7061427 complement(1100357..1100953) 1 NC_011601.1 stationary phase that binds TrpR repressor; TrpR binding protein WrbA 1100953 wrbA 7061427 wrbA Escherichia coli O127:H6 str. E2348/69 TrpR binding protein WrbA YP_002328615.1 1100357 R 574521 CDS YP_002328616.1 215486185 7064845 1101326..1101499 1 NC_011601.1 hypothetical protein 1101499 ymdF 7064845 ymdF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328616.1 1101326 D 574521 CDS YP_002328617.1 215486186 7062025 complement(1101582..1102910) 1 NC_011601.1 transporter 1102910 rutG 7062025 rutG Escherichia coli O127:H6 str. E2348/69 transporter YP_002328617.1 1101582 R 574521 CDS YP_002328618.1 215486187 7064586 complement(1102931..1103425) 1 NC_011601.1 oxidoreductase, flavin: NADH component 1103425 rutF 7064586 rutF Escherichia coli O127:H6 str. E2348/69 oxidoreductase, flavin: NADH component YP_002328618.1 1102931 R 574521 CDS YP_002328619.1 215486188 7064585 complement(1103436..1104026) 1 NC_011601.1 hypothetical protein 1104026 rutE 7064585 rutE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328619.1 1103436 R 574521 CDS YP_002328620.1 215486189 7064584 complement(1104036..1104836) 1 NC_011601.1 hydrolase 1104836 rutD 7064584 rutD Escherichia coli O127:H6 str. E2348/69 hydrolase YP_002328620.1 1104036 R 574521 CDS YP_002328621.1 215486190 7064583 complement(1104844..1105230) 1 NC_011601.1 hypothetical protein 1105230 rutC 7064583 rutC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328621.1 1104844 R 574521 CDS YP_002328622.1 215486191 7064582 complement(1105242..1105934) 1 NC_011601.1 hypothetical protein 1105934 rutB 7064582 rutB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328622.1 1105242 R 574521 CDS YP_002328623.1 215486192 7064581 complement(1105934..1107025) 1 NC_011601.1 monooxygenase 1107025 rutA 7064581 rutA Escherichia coli O127:H6 str. E2348/69 monooxygenase YP_002328623.1 1105934 R 574521 CDS YP_002328624.1 215486193 7064580 1107313..1107951 1 NC_011601.1 DNA-binding transcriptional regulator 1107951 rutR 7064580 rutR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002328624.1 1107313 D 574521 CDS YP_002328625.1 215486194 7064587 complement(1107991..1111953) 1 NC_011601.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 1111953 putA 7064587 putA Escherichia coli O127:H6 str. E2348/69 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_002328625.1 1107991 R 574521 CDS YP_002328626.1 215486195 7063925 1112376..1113884 1 NC_011601.1 proline: sodium symporter 1113884 putP 7063925 putP Escherichia coli O127:H6 str. E2348/69 proline: sodium symporter YP_002328626.1 1112376 D 574521 CDS YP_002328627.1 215486196 7063926 1114104..1114934 1 NC_011601.1 high-affinity Fe2+/Pb2+ permease 1114934 efeU 7063926 efeU Escherichia coli O127:H6 str. E2348/69 high-affinity Fe2+/Pb2+ permease YP_002328627.1 1114104 D 574521 CDS YP_002328628.1 215486197 7063839 1114992..1116119 1 NC_011601.1 hypothetical protein 1116119 ycdO 7063839 ycdO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328628.1 1114992 D 574521 CDS YP_002328629.1 215486198 7061437 1116125..1117396 1 NC_011601.1 hypothetical protein 1117396 ycdB 7061437 ycdB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328629.1 1116125 D 574521 CDS YP_002328630.1 215486199 7061436 1117747..1118811 1 NC_011601.1 hypothetical protein 1118811 phoH 7061436 phoH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328630.1 1117747 D 574521 CDS YP_002328631.1 215486200 7060745 1119374..1120060 1 NC_011601.1 hypothetical protein 1120060 7060745 E2348C_1071 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328631.1 1119374 D 574521 CDS YP_002328632.1 215486201 7064956 1120326..1121543 1 NC_011601.1 integrase 1121543 7064956 E2348C_1072 Escherichia coli O127:H6 str. E2348/69 integrase YP_002328632.1 1120326 D 574521 CDS YP_002328633.1 215486202 7064687 complement(1121713..1123242) 1 NC_011601.1 hypothetical protein 1123242 7064687 E2348C_1073 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328633.1 1121713 R 574521 CDS YP_002328634.1 215486203 7064688 1123602..1125437 1 NC_011601.1 hypothetical protein 1125437 7064688 E2348C_1074 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328634.1 1123602 D 574521 CDS YP_002328635.1 215486204 7064689 1126812..1127375 1 NC_011601.1 hypothetical protein 1127375 7064689 E2348C_1075 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328635.1 1126812 D 574521 CDS YP_002328636.1 215486205 7064690 complement(1129032..1129571) 1 NC_011601.1 hypothetical protein 1129571 7064690 E2348C_1078 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328636.1 1129032 R 574521 CDS YP_002328637.1 215486206 7064691 complement(1129858..1137732) 1 NC_011601.1 Efa1/LifA-like protein 1137732 7064691 E2348C_1079 Escherichia coli O127:H6 str. E2348/69 Efa1/LifA-like protein YP_002328637.1 1129858 R 574521 CDS YP_002328638.1 215486207 7064692 complement(1138203..1138709) 1 NC_011601.1 T3SS secreted effector NleE-like protein with internal deletion of 56 aa 1138709 7064692 E2348C_1080 Escherichia coli O127:H6 str. E2348/69 T3SS secreted effector NleE-like protein with internal deletion of 56 aa YP_002328638.1 1138203 R 574521 CDS YP_002328639.1 215486208 7064974 1144298..1144840 1 NC_011601.1 transposase 1144840 7064974 E2348C_1084 Escherichia coli O127:H6 str. E2348/69 transposase YP_002328639.1 1144298 D 574521 CDS YP_002328640.1 215486209 7064975 1144892..1145218 1 NC_011601.1 transposase Orf1 of IS629 1145218 7064975 E2348C_1085 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS629 YP_002328640.1 1144892 D 574521 CDS YP_002328641.1 215486210 7064694 1145215..1146105 1 NC_011601.1 transposase Orf2 of IS629 1146105 7064694 E2348C_1086 Escherichia coli O127:H6 str. E2348/69 transposase Orf2 of IS629 YP_002328641.1 1145215 D 574521 CDS YP_002328642.1 215486211 7064977 1147639..1148661 1 NC_011601.1 transposase Orf1 of IS100 1148661 7064977 E2348C_1088 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS100 YP_002328642.1 1147639 D 574521 CDS YP_002328643.1 215486212 7064695 1148661..1149440 1 NC_011601.1 transposase/IS protein 1149440 7064695 E2348C_1089 Escherichia coli O127:H6 str. E2348/69 transposase/IS protein YP_002328643.1 1148661 D 574521 CDS YP_002328644.1 215486213 7064978 complement(1150268..1150984) 1 NC_011601.1 hypothetical protein 1150984 7064978 E2348C_1090 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328644.1 1150268 R 574521 CDS YP_002328645.1 215486214 7064696 complement(1150984..1154079) 1 NC_011601.1 HsdR family type I site-specific deoxyribonuclease 1154079 7064696 E2348C_1091 Escherichia coli O127:H6 str. E2348/69 HsdR family type I site-specific deoxyribonuclease YP_002328645.1 1150984 R 574521 CDS YP_002328646.1 215486215 7064697 complement(1154098..1155126) 1 NC_011601.1 hypothetical protein 1155126 7064697 E2348C_1092 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328646.1 1154098 R 574521 CDS YP_002328647.1 215486216 7064698 complement(1155162..1155818) 1 NC_011601.1 hypothetical protein 1155818 7064698 E2348C_1093 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328647.1 1155162 R 574521 CDS YP_002328648.1 215486217 7064699 complement(1155830..1157179) 1 NC_011601.1 type I restriction-modification enzyme, S subunit 1157179 7064699 E2348C_1094 Escherichia coli O127:H6 str. E2348/69 type I restriction-modification enzyme, S subunit YP_002328648.1 1155830 R 574521 CDS YP_002328649.1 215486218 7064700 complement(1157191..1159629) 1 NC_011601.1 type I restriction-modification enzyme, M subunit 1159629 7064700 E2348C_1095 Escherichia coli O127:H6 str. E2348/69 type I restriction-modification enzyme, M subunit YP_002328649.1 1157191 R 574521 CDS YP_002328650.1 215486219 7064701 complement(1159669..1159908) 1 NC_011601.1 hypothetical protein 1159908 7064701 E2348C_1096 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328650.1 1159669 R 574521 CDS YP_002328651.1 215486220 7064702 complement(1160137..1160445) 1 NC_011601.1 hypothetical protein 1160445 7064702 E2348C_1097 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328651.1 1160137 R 574521 CDS YP_002328652.1 215486221 7064703 1161060..1161428 1 NC_011601.1 hypothetical protein 1161428 7064703 E2348C_1098 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328652.1 1161060 D 574521 CDS YP_002328653.1 215486222 7064704 1161498..1161884 1 NC_011601.1 hypothetical protein 1161884 7064704 E2348C_1099 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328653.1 1161498 D 574521 CDS YP_002328654.1 215486223 7064705 complement(1162034..1162303) 1 NC_011601.1 hypothetical protein 1162303 7064705 E2348C_1100 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328654.1 1162034 R 574521 CDS YP_002328655.1 215486224 7064979 complement(1162899..1163765) 1 NC_011601.1 transposase Orf2 of ISEc17 1163765 7064979 E2348C_1101 Escherichia coli O127:H6 str. E2348/69 transposase Orf2 of ISEc17 YP_002328655.1 1162899 R 574521 CDS YP_002328656.1 215486225 7064706 complement(1163762..1164061) 1 NC_011601.1 transposase Orf1 of ISEc17 1164061 7064706 E2348C_1102 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of ISEc17 YP_002328656.1 1163762 R 574521 CDS YP_002328657.1 215486226 7064980 1164464..1165867 1 NC_011601.1 transposase Orf3 of IS66 family IS element 1165867 7064980 E2348C_1103 Escherichia coli O127:H6 str. E2348/69 transposase Orf3 of IS66 family IS element YP_002328657.1 1164464 D 574521 CDS YP_002328658.1 215486227 7064982 complement(1167047..1167937) 1 NC_011601.1 transposase Orf2 of IS629 1167937 7064982 E2348C_1105 Escherichia coli O127:H6 str. E2348/69 transposase Orf2 of IS629 YP_002328658.1 1167047 R 574521 CDS YP_002328659.1 215486228 7064707 complement(1167934..1168260) 1 NC_011601.1 transposase Orf1 of IS629 1168260 7064707 E2348C_1106 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS629 YP_002328659.1 1167934 R 574521 CDS YP_002328660.1 215486229 7064710 1171483..1173867 1 NC_011601.1 hypothetical protein 1173867 7064710 E2348C_1110 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328660.1 1171483 D 574521 CDS YP_002328661.1 215486230 7064711 1173864..1174769 1 NC_011601.1 hypothetical protein 1174769 7064711 E2348C_1111 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328661.1 1173864 D 574521 CDS YP_002328662.1 215486231 7064712 1174766..1175836 1 NC_011601.1 hypothetical protein 1175836 7064712 E2348C_1112 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328662.1 1174766 D 574521 CDS YP_002328663.1 215486232 7064713 complement(1175941..1176105) 1 NC_011601.1 hypothetical protein 1176105 7064713 E2348C_1113 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328663.1 1175941 R 574521 CDS YP_002328664.1 215486233 7064714 1176176..1176994 1 NC_011601.1 hypothetical protein 1176994 7064714 E2348C_1114 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328664.1 1176176 D 574521 CDS YP_002328665.1 215486234 7064715 1177085..1177570 1 NC_011601.1 hypothetical protein 1177570 7064715 E2348C_1115 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328665.1 1177085 D 574521 CDS YP_002328666.1 215486235 7064716 1177586..1178062 1 NC_011601.1 hypothetical protein 1178062 7064716 E2348C_1116 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328666.1 1177586 D 574521 CDS YP_002328667.1 215486236 7064717 1178125..1178346 1 NC_011601.1 hypothetical protein 1178346 7064717 E2348C_1117 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328667.1 1178125 D 574521 CDS YP_002328668.1 215486237 7064718 1178509..1178883 1 NC_011601.1 hypothetical protein 1178883 7064718 E2348C_1118 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328668.1 1178509 D 574521 CDS YP_002328669.1 215486238 7064719 1178930..1179304 1 NC_011601.1 hypothetical protein 1179304 7064719 E2348C_1119 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328669.1 1178930 D 574521 CDS YP_002328670.1 215486239 7064720 1179301..1179792 1 NC_011601.1 hypothetical protein 1179792 7064720 E2348C_1120 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328670.1 1179301 D 574521 CDS YP_002328671.1 215486240 7064721 1179804..1180001 1 NC_011601.1 hypothetical protein 1180001 7064721 E2348C_1121 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328671.1 1179804 D 574521 CDS YP_002328672.1 215486241 7064722 1180086..1180928 1 NC_011601.1 hypothetical protein 1180928 7064722 E2348C_1122 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328672.1 1180086 D 574521 CDS YP_002328673.1 215486242 7062707 1181398..1182336 1 NC_011601.1 2-ketoacid reductase 1182336 ghrA 7062707 ghrA Escherichia coli O127:H6 str. E2348/69 2-ketoacid reductase YP_002328673.1 1181398 D 574521 CDS YP_002328674.1 215486243 7061654 1182391..1183128 1 NC_011601.1 hydrolase 1183128 ycdX 7061654 ycdX Escherichia coli O127:H6 str. E2348/69 hydrolase YP_002328674.1 1182391 D 574521 CDS YP_002328675.1 215486244 7061438 1183152..1183706 1 NC_011601.1 hypothetical protein 1183706 ycdY 7061438 ycdY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328675.1 1183152 D 574521 CDS YP_002328676.1 215486245 7061439 1183778..1184299 1 NC_011601.1 hypothetical protein 1184299 ycdZ 7061439 ycdZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328676.1 1183778 D 574521 CDS YP_002328677.1 215486246 7061440 complement(1184363..1185196) 1 NC_011601.1 outer membrane lipoprotein 1185196 csgG 7061440 csgG Escherichia coli O127:H6 str. E2348/69 outer membrane lipoprotein YP_002328677.1 1184363 R 574521 CDS YP_002328678.1 215486247 7062856 complement(1185223..1185639) 1 NC_011601.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 1185639 csgF 7062856 csgF Escherichia coli O127:H6 str. E2348/69 curli assembly protein CsgF YP_002328678.1 1185223 R 574521 CDS YP_002328679.1 215486248 7062855 complement(1185664..1186053) 1 NC_011601.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 1186053 csgE 7062855 csgE Escherichia coli O127:H6 str. E2348/69 curli assembly protein CsgE YP_002328679.1 1185664 R 574521 CDS YP_002328680.1 215486249 7062854 complement(1186058..1186708) 1 NC_011601.1 activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD 1186708 csgD 7062854 csgD Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator CsgD YP_002328680.1 1186058 R 574521 CDS YP_002328681.1 215486250 7062853 complement(1187120..1187359) 1 NC_011601.1 hypothetical protein 1187359 7062853 E2348C_1131 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328681.1 1187120 R 574521 CDS YP_002328682.1 215486251 7064724 1187462..1187917 1 NC_011601.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1187917 csgB 7064724 csgB Escherichia coli O127:H6 str. E2348/69 curlin minor subunit YP_002328682.1 1187462 D 574521 CDS YP_002328683.1 215486252 7062851 1187958..1188413 1 NC_011601.1 cryptic curlin major subunit 1188413 csgA 7062851 csgA Escherichia coli O127:H6 str. E2348/69 cryptic curlin major subunit YP_002328683.1 1187958 D 574521 CDS YP_002328684.1 215486253 7062850 1188472..1188804 1 NC_011601.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers; autoagglutination protein 1188804 csgC 7062850 csgC Escherichia coli O127:H6 str. E2348/69 autoagglutination protein YP_002328684.1 1188472 D 574521 CDS YP_002328685.1 215486254 7062852 1188925..1189236 1 NC_011601.1 hypothetical protein 1189236 ymdA 7062852 ymdA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328685.1 1188925 D 574521 CDS YP_002328686.1 215486255 7062022 1189331..1189864 1 NC_011601.1 hypothetical protein 1189864 ymdB 7062022 ymdB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328686.1 1189331 D 574521 CDS YP_002328687.1 215486256 7062023 1189866..1191287 1 NC_011601.1 hydrolase 1191287 ymdC 7062023 ymdC Escherichia coli O127:H6 str. E2348/69 hydrolase YP_002328687.1 1189866 D 574521 CDS YP_002328688.1 215486257 7062024 complement(1191295..1192452) 1 NC_011601.1 required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 1192452 mdoC 7062024 mdoC Escherichia coli O127:H6 str. E2348/69 glucans biosynthesis protein YP_002328688.1 1191295 R 574521 CDS YP_002328689.1 215486258 7065302 1192846..1194381 1 NC_011601.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1194381 mdoG 7065302 mdoG Escherichia coli O127:H6 str. E2348/69 glucan biosynthesis protein G YP_002328689.1 1192846 D 574521 CDS YP_002328690.1 215486259 7065304 1194374..1196917 1 NC_011601.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1196917 mdoH 7065304 mdoH Escherichia coli O127:H6 str. E2348/69 glucosyltransferase MdoH YP_002328690.1 1194374 D 574521 CDS YP_002328691.1 215486260 7065305 1197090..1197317 1 NC_011601.1 hypothetical protein 1197317 yceK 7065305 yceK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328691.1 1197090 D 574521 CDS YP_002328692.1 215486261 7061449 complement(1197318..1197692) 1 NC_011601.1 hypothetical protein 1197692 msyB 7061449 msyB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328692.1 1197318 R 574521 CDS YP_002328693.1 215486262 7060876 complement(1197775..1199001) 1 NC_011601.1 Confers resistance to fosfomycin and deoxycholate; drug efflux system protein MdtG 1199001 mdtG 7060876 mdtG Escherichia coli O127:H6 str. E2348/69 drug efflux system protein MdtG YP_002328693.1 1197775 R 574521 CDS YP_002328694.1 215486263 7065312 complement(1199173..1200093) 1 NC_011601.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1200093 lpxL 7065312 lpxL Escherichia coli O127:H6 str. E2348/69 lipid A biosynthesis lauroyl acyltransferase YP_002328694.1 1199173 R 574521 CDS YP_002328695.1 215486264 7061578 1200318..1201370 1 NC_011601.1 hypothetical protein 1201370 yceA 7061578 yceA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328695.1 1200318 D 574521 CDS YP_002328696.1 215486265 7061441 complement(1201412..1201987) 1 NC_011601.1 hypothetical protein 1201987 yceI 7061441 yceI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328696.1 1201412 R 574521 CDS YP_002328697.1 215486266 7061447 complement(1201991..1202557) 1 NC_011601.1 cytochrome b561 1202557 yceJ 7061447 yceJ Escherichia coli O127:H6 str. E2348/69 cytochrome b561 YP_002328697.1 1201991 R 574521 CDS YP_002328698.1 215486267 7061448 complement(1202819..1202932) 1 NC_011601.1 hypothetical protein 1202932 yceO 7061448 yceO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328698.1 1202819 R 574521 CDS YP_002328699.1 215486268 7061452 complement(1202980..1204098) 1 NC_011601.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 1204098 solA 7061452 solA Escherichia coli O127:H6 str. E2348/69 N-methyltryptophan oxidase YP_002328699.1 1202980 R 574521 CDS YP_002328700.1 215486269 7062737 complement(1204213..1204467) 1 NC_011601.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS 1204467 bssS 7062737 bssS Escherichia coli O127:H6 str. E2348/69 biofilm formation regulatory protein BssS YP_002328700.1 1204213 R 574521 CDS YP_002328701.1 215486270 7062533 complement(1204757..1205002) 1 NC_011601.1 DNA damage-inducible protein I 1205002 dinI 7062533 dinI Escherichia coli O127:H6 str. E2348/69 DNA damage-inducible protein I YP_002328701.1 1204757 R 574521 CDS YP_002328702.1 215486271 7065032 complement(1205076..1206122) 1 NC_011601.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1206122 pyrC 7065032 pyrC Escherichia coli O127:H6 str. E2348/69 dihydroorotase YP_002328702.1 1205076 R 574521 CDS YP_002328703.1 215486272 7063930 complement(1206228..1206788) 1 NC_011601.1 hypothetical protein 1206788 yceB 7063930 yceB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328703.1 1206228 R 574521 CDS YP_002328704.1 215486273 7061442 complement(1206922..1207569) 1 NC_011601.1 cofactor involved in the reduction of disulfides; glutaredoxin 1207569 grxB 7061442 grxB Escherichia coli O127:H6 str. E2348/69 glutaredoxin YP_002328704.1 1206922 R 574521 CDS YP_002328705.1 215486274 7064247 complement(1207633..1208841) 1 NC_011601.1 Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 1208841 mdtH 7064247 mdtH Escherichia coli O127:H6 str. E2348/69 multidrug resistance protein MdtH YP_002328705.1 1207633 R 574521 CDS YP_002328706.1 215486275 7065313 1209077..1209661 1 NC_011601.1 ribosomal-protein-S5-alanine N-acetyltransferase 1209661 rimJ 7065313 rimJ Escherichia coli O127:H6 str. E2348/69 ribosomal-protein-S5-alanine N-acetyltransferase YP_002328706.1 1209077 D 574521 CDS YP_002328707.1 215486276 7060828 1209672..1210319 1 NC_011601.1 hypothetical protein 1210319 yceH 7060828 yceH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328707.1 1209672 D 574521 CDS YP_002328708.1 215486277 7061446 1210321..1211244 1 NC_011601.1 oxidoreductase with NAD(P)-binding Rossmann-fold domain 1211244 yceM 7061446 yceM Escherichia coli O127:H6 str. E2348/69 oxidoreductase with NAD(P)-binding Rossmann-fold domain YP_002328708.1 1210321 D 574521 CDS YP_002328709.1 215486278 7061450 1211354..1212889 1 NC_011601.1 hypothetical protein 1212889 yceN 7061450 yceN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328709.1 1211354 D 574521 CDS YP_002328710.1 215486279 7061451 complement(1212929..1213345) 1 NC_011601.1 export chaperone for FlgK and FlgL 1213345 flgN 7061451 flgN Escherichia coli O127:H6 str. E2348/69 export chaperone for FlgK and FlgL YP_002328710.1 1212929 R 574521 CDS YP_002328711.1 215486280 7061907 complement(1213350..1213643) 1 NC_011601.1 regulates the flagellar specific sigma28 transcription factor; anti-sigma-28 factor FlgM 1213643 flgM 7061907 flgM Escherichia coli O127:H6 str. E2348/69 anti-sigma-28 factor FlgM YP_002328711.1 1213350 R 574521 CDS YP_002328712.1 215486281 7061906 complement(1213719..1214378) 1 NC_011601.1 required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 1214378 flgA 7061906 flgA Escherichia coli O127:H6 str. E2348/69 flagellar basal body P-ring biosynthesis protein FlgA YP_002328712.1 1213719 R 574521 CDS YP_002328713.1 215486282 7062138 1214533..1214949 1 NC_011601.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal-body rod protein FlgB 1214949 flgB 7062138 flgB Escherichia coli O127:H6 str. E2348/69 flagellar basal-body rod protein FlgB YP_002328713.1 1214533 D 574521 CDS YP_002328714.1 215486283 7062139 1214953..1215357 1 NC_011601.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1215357 flgC 7062139 flgC Escherichia coli O127:H6 str. E2348/69 flagellar basal body rod protein FlgC YP_002328714.1 1214953 D 574521 CDS YP_002328715.1 215486284 7061819 1215369..1216064 1 NC_011601.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1216064 flgD 7061819 flgD Escherichia coli O127:H6 str. E2348/69 flagellar basal body rod modification protein YP_002328715.1 1215369 D 574521 CDS YP_002328716.1 215486285 7061897 1216089..1217294 1 NC_011601.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1217294 flgE 7061897 flgE Escherichia coli O127:H6 str. E2348/69 flagellar hook protein FlgE YP_002328716.1 1216089 D 574521 CDS YP_002328717.1 215486286 7061898 1217314..1218069 1 NC_011601.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1218069 flgF 7061898 flgF Escherichia coli O127:H6 str. E2348/69 flagellar basal body rod protein FlgF YP_002328717.1 1217314 D 574521 CDS YP_002328718.1 215486287 7061899 1218241..1219023 1 NC_011601.1 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1219023 flgG 7061899 flgG Escherichia coli O127:H6 str. E2348/69 flagellar basal body rod protein FlgG YP_002328718.1 1218241 D 574521 CDS YP_002328719.1 215486288 7061900 1219076..1219774 1 NC_011601.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1219774 flgH 7061900 flgH Escherichia coli O127:H6 str. E2348/69 flagellar basal body L-ring protein YP_002328719.1 1219076 D 574521 CDS YP_002328720.1 215486289 7061901 1219786..1220883 1 NC_011601.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring biosynthesis protein FlgA 1220883 flgI 7061901 flgI Escherichia coli O127:H6 str. E2348/69 flagellar basal body P-ring biosynthesis protein FlgA YP_002328720.1 1219786 D 574521 CDS YP_002328721.1 215486290 7061902 1220883..1221824 1 NC_011601.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1221824 flgJ 7061902 flgJ Escherichia coli O127:H6 str. E2348/69 flagellar rod assembly protein/muramidase FlgJ YP_002328721.1 1220883 D 574521 CDS YP_002328722.1 215486291 7061903 1221890..1223533 1 NC_011601.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1223533 flgK 7061903 flgK Escherichia coli O127:H6 str. E2348/69 flagellar hook-associated protein FlgK YP_002328722.1 1221890 D 574521 CDS YP_002328723.1 215486292 7061904 1223545..1224498 1 NC_011601.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1224498 flgL 7061904 flgL Escherichia coli O127:H6 str. E2348/69 flagellar hook-associated protein FlgL YP_002328723.1 1223545 D 574521 CDS YP_002328724.1 215486293 7061905 complement(1224593..1225087) 1 NC_011601.1 acetyltransferase 1225087 7061905 E2348C_1174 Escherichia coli O127:H6 str. E2348/69 acetyltransferase YP_002328724.1 1224593 R 574521 CDS YP_002328725.1 215486294 7064725 complement(1225084..1225377) 1 NC_011601.1 hypothetical protein 1225377 7064725 E2348C_1175 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328725.1 1225084 R 574521 CDS YP_002328726.1 215486295 7064726 complement(1225511..1228696) 1 NC_011601.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 1228696 rne 7064726 rne Escherichia coli O127:H6 str. E2348/69 ribonuclease E YP_002328726.1 1225511 R 574521 CDS YP_002328727.1 215486296 7060851 1228831..1229151 1 NC_011601.1 hypothetical protein 1229151 yceQ 7060851 yceQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328727.1 1228831 D 574521 CDS YP_002328728.1 215486297 7061453 1229269..1230228 1 NC_011601.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1230228 rluC 7061453 rluC Escherichia coli O127:H6 str. E2348/69 23S rRNA pseudouridylate synthase C YP_002328728.1 1229269 D 574521 CDS YP_002328729.1 215486298 7060840 complement(1230340..1230924) 1 NC_011601.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1230924 yceF 7060840 yceF Escherichia coli O127:H6 str. E2348/69 Maf-like protein YP_002328729.1 1230340 R 574521 CDS YP_002328730.1 215486299 7061325 1231123..1231644 1 NC_011601.1 hypothetical protein 1231644 yceD 7061325 yceD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328730.1 1231123 D 574521 CDS YP_002328731.1 215486300 7061443 1231696..1231869 1 NC_011601.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1231869 rpmF 7061443 rpmF Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L32 YP_002328731.1 1231696 D 574521 CDS YP_002328732.1 215486301 7061858 1231980..1233020 1 NC_011601.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1233020 plsX 7061858 plsX Escherichia coli O127:H6 str. E2348/69 glycerol-3-phosphate acyltransferase PlsX YP_002328732.1 1231980 D 574521 CDS YP_002328733.1 215486302 7060758 1233088..1234041 1 NC_011601.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1234041 fabH 7060758 fabH Escherichia coli O127:H6 str. E2348/69 3-oxoacyl-ACP synthase YP_002328733.1 1233088 D 574521 CDS YP_002328734.1 215486303 7062067 1234057..1234986 1 NC_011601.1 malonyl-CoA-[acyl-carrier-protein] transacylase 1234986 fabD 7062067 fabD Escherichia coli O127:H6 str. E2348/69 malonyl-CoA-[acyl-carrier-protein] transacylase YP_002328734.1 1234057 D 574521 CDS YP_002328735.1 215486304 7062064 1234999..1235733 1 NC_011601.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1235733 fabG 7062064 fabG Escherichia coli O127:H6 str. E2348/69 3-ketoacyl-ACP reductase YP_002328735.1 1234999 D 574521 CDS YP_002328736.1 215486305 7062066 1235944..1236180 1 NC_011601.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1236180 acpP 7062066 acpP Escherichia coli O127:H6 str. E2348/69 acyl carrier protein YP_002328736.1 1235944 D 574521 CDS YP_002328737.1 215486306 7062393 1236268..1237509 1 NC_011601.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1237509 fabF 7062393 fabF Escherichia coli O127:H6 str. E2348/69 3-oxoacyl-ACP synthase YP_002328737.1 1236268 D 574521 CDS YP_002328738.1 215486307 7062065 1237629..1238438 1 NC_011601.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1238438 pabC 7062065 pabC Escherichia coli O127:H6 str. E2348/69 4-amino-4-deoxychorismate lyase YP_002328738.1 1237629 D 574521 CDS YP_002328739.1 215486308 7062902 1238441..1239463 1 NC_011601.1 hypothetical protein 1239463 yceG 7062902 yceG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328739.1 1238441 D 574521 CDS YP_002328740.1 215486309 7061445 1239453..1240094 1 NC_011601.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1240094 tmk 7061445 tmk Escherichia coli O127:H6 str. E2348/69 thymidylate kinase YP_002328740.1 1239453 D 574521 CDS YP_002328741.1 215486310 7061809 1240091..1241095 1 NC_011601.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1241095 holB 7061809 holB Escherichia coli O127:H6 str. E2348/69 DNA polymerase III subunit delta' YP_002328741.1 1240091 D 574521 CDS YP_002328742.1 215486311 7062172 1241106..1241903 1 NC_011601.1 metallodependent hydrolase 1241903 ycfH 7062172 ycfH Escherichia coli O127:H6 str. E2348/69 metallodependent hydrolase YP_002328742.1 1241106 D 574521 CDS YP_002328743.1 215486312 7061455 1242197..1243630 1 NC_011601.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunit IIBC 1243630 ptsG 7061455 ptsG Escherichia coli O127:H6 str. E2348/69 PTS system glucose-specific transporter subunit IIBC YP_002328743.1 1242197 D 574521 CDS YP_002328744.1 215486313 7061338 complement(1243690..1245879) 1 NC_011601.1 ferric-rhodotorulic acid outer membrane transporter 1245879 fhuE 7061338 fhuE Escherichia coli O127:H6 str. E2348/69 ferric-rhodotorulic acid outer membrane transporter YP_002328744.1 1243690 R 574521 CDS YP_002328745.1 215486314 7062115 1246213..1246572 1 NC_011601.1 purine nucleoside phosphoramidase 1246572 hinT 7062115 hinT Escherichia coli O127:H6 str. E2348/69 purine nucleoside phosphoramidase YP_002328745.1 1246213 D 574521 CDS YP_002328746.1 215486315 7062140 1246575..1246952 1 NC_011601.1 hypothetical protein 1246952 ycfL 7062140 ycfL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328746.1 1246575 D 574521 CDS YP_002328747.1 215486316 7061457 1246966..1247607 1 NC_011601.1 outer membrane lipoprotein 1247607 ycfM 7061457 ycfM Escherichia coli O127:H6 str. E2348/69 outer membrane lipoprotein YP_002328747.1 1246966 D 574521 CDS YP_002328748.1 215486317 7061458 1247588..1248412 1 NC_011601.1 catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1248412 thiK 7061458 thiK Escherichia coli O127:H6 str. E2348/69 thiamine kinase YP_002328748.1 1247588 D 574521 CDS YP_002328749.1 215486318 7061787 1248423..1249448 1 NC_011601.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1249448 nagZ 7061787 nagZ Escherichia coli O127:H6 str. E2348/69 beta-hexosaminidase YP_002328749.1 1248423 D 574521 CDS YP_002328750.1 215486319 7060917 1249471..1250013 1 NC_011601.1 hypothetical protein 1250013 ycfP 7060917 ycfP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328750.1 1249471 D 574521 CDS YP_002328751.1 215486320 7061459 1250412..1251716 1 NC_011601.1 respiratory NADH dehydrogenase 2/cupricreductase 1251716 ndh 7061459 ndh Escherichia coli O127:H6 str. E2348/69 respiratory NADH dehydrogenase 2/cupricreductase YP_002328751.1 1250412 D 574521 CDS YP_002328752.1 215486321 7065376 1251943..1252482 1 NC_011601.1 hypothetical protein 1252482 ycfJ 7065376 ycfJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328752.1 1251943 D 574521 CDS YP_002328753.1 215486322 7061456 complement(1252544..1253176) 1 NC_011601.1 DNA-binding transcriptional regulator 1253176 ycfQ 7061456 ycfQ Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002328753.1 1252544 R 574521 CDS YP_002328754.1 215486323 7061460 1253417..1253674 1 NC_011601.1 outer membrane protein that influences biofilm formation 1253674 bhsA 7061460 bhsA Escherichia coli O127:H6 str. E2348/69 outer membrane protein that influences biofilm formation YP_002328754.1 1253417 D 574521 CDS YP_002328755.1 215486324 7062519 complement(1253756..1254718) 1 NC_011601.1 hypothetical protein 1254718 ycfS 7062519 ycfS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328755.1 1253756 R 574521 CDS YP_002328756.1 215486325 7061461 complement(1254861..1258307) 1 NC_011601.1 transcription-repair coupling factor 1258307 mfd 7061461 mfd Escherichia coli O127:H6 str. E2348/69 transcription-repair coupling factor YP_002328756.1 1254861 R 574521 CDS YP_002328757.1 215486326 7063776 complement(1258435..1259508) 1 NC_011601.1 hypothetical protein 1259508 ycfT 7063776 ycfT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328757.1 1258435 R 574521 CDS YP_002328758.1 215486327 7061462 1259769..1260968 1 NC_011601.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1260968 lolC 7061462 lolC Escherichia coli O127:H6 str. E2348/69 outer membrane-specific lipoprotein transporter subunit LolC YP_002328758.1 1259769 D 574521 CDS YP_002328759.1 215486328 7061556 1260961..1261662 1 NC_011601.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1261662 lolD 7061556 lolD Escherichia coli O127:H6 str. E2348/69 lipoprotein transporter ATP-binding subunit YP_002328759.1 1260961 D 574521 CDS YP_002328760.1 215486329 7061557 1261662..1262906 1 NC_011601.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1262906 lolE 7061557 lolE Escherichia coli O127:H6 str. E2348/69 outer membrane-specific lipoprotein transporter subunit LolE YP_002328760.1 1261662 D 574521 CDS YP_002328761.1 215486330 7061558 1262935..1263846 1 NC_011601.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1263846 nagK 7061558 nagK Escherichia coli O127:H6 str. E2348/69 N-acetyl-D-glucosamine kinase YP_002328761.1 1262935 D 574521 CDS YP_002328762.1 215486331 7060916 1263862..1264683 1 NC_011601.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1264683 cobB 7060916 cobB Escherichia coli O127:H6 str. E2348/69 NAD-dependent deacetylase YP_002328762.1 1263862 D 574521 CDS YP_002328763.1 215486332 7062824 complement(1264821..1265609) 1 NC_011601.1 hypothetical protein 1265609 ycfZ 7062824 ycfZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328763.1 1264821 R 574521 CDS YP_002328764.1 215486333 7061463 complement(1265606..1266067) 1 NC_011601.1 hypothetical protein 1266067 ymfA 7061463 ymfA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328764.1 1265606 R 574521 CDS YP_002328765.1 215486334 7062026 complement(1266125..1267171) 1 NC_011601.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter substrate-binding protein 1267171 potD 7062026 potD Escherichia coli O127:H6 str. E2348/69 spermidine/putrescine ABC transporter substrate-binding protein YP_002328765.1 1266125 R 574521 CDS YP_002328766.1 215486335 7060773 complement(1267168..1267962) 1 NC_011601.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 1267962 potC 7060773 potC Escherichia coli O127:H6 str. E2348/69 spermidine/putrescine ABC transporter membrane protein YP_002328766.1 1267168 R 574521 CDS YP_002328767.1 215486336 7061169 complement(1268129..1269247) 1 NC_011601.1 integrase 1269247 7061169 E2348C_1217 Escherichia coli O127:H6 str. E2348/69 integrase YP_002328767.1 1268129 R 574521 CDS YP_002328768.1 215486337 7064727 complement(1269216..1269485) 1 NC_011601.1 excisionase 1269485 7064727 E2348C_1218 Escherichia coli O127:H6 str. E2348/69 excisionase YP_002328768.1 1269216 R 574521 CDS YP_002328769.1 215486338 7064728 complement(1269547..1272018) 1 NC_011601.1 exonuclease 1272018 7064728 E2348C_1219 Escherichia coli O127:H6 str. E2348/69 exonuclease YP_002328769.1 1269547 R 574521 CDS YP_002328770.1 215486339 7064730 complement(1272299..1272487) 1 NC_011601.1 cell division inhibition protein DicB 1272487 7064730 E2348C_1221 Escherichia coli O127:H6 str. E2348/69 cell division inhibition protein DicB YP_002328770.1 1272299 R 574521 CDS YP_002328771.1 215486340 7065026 1272888..1273052 1 NC_011601.1 hypothetical protein 1273052 7065026 E2348C_1222 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328771.1 1272888 D 574521 CDS YP_002328772.1 215486341 7064732 complement(1273056..1273274) 1 NC_011601.1 hypothetical protein 1273274 7064732 E2348C_1223 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328772.1 1273056 R 574521 CDS YP_002328773.1 215486342 7064733 complement(1273304..1273432) 1 NC_011601.1 hypothetical protein 1273432 7064733 E2348C_1224 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328773.1 1273304 R 574521 CDS YP_002328774.1 215486343 7064734 complement(1273434..1273682) 1 NC_011601.1 hypothetical protein 1273682 7064734 E2348C_1225 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328774.1 1273434 R 574521 CDS YP_002328775.1 215486344 7064735 complement(1273781..1274188) 1 NC_011601.1 The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA 1274188 7064735 E2348C_1226 Escherichia coli O127:H6 str. E2348/69 transcriptional repressor DicA YP_002328775.1 1273781 R 574521 CDS YP_002328776.1 215486345 7064736 1274266..1274493 1 NC_011601.1 DNA-binding transcriptional regulator DicC 1274493 7064736 E2348C_1227 Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator DicC YP_002328776.1 1274266 D 574521 CDS YP_002328777.1 215486346 7064737 1274477..1275028 1 NC_011601.1 hypothetical protein 1275028 7064737 E2348C_1228 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328777.1 1274477 D 574521 CDS YP_002328778.1 215486347 7064738 1275000..1276040 1 NC_011601.1 replication protein 1276040 7064738 E2348C_1229 Escherichia coli O127:H6 str. E2348/69 replication protein YP_002328778.1 1275000 D 574521 CDS YP_002328779.1 215486348 7064739 1275829..1276494 1 NC_011601.1 replication protein 1276494 7064739 E2348C_1230 Escherichia coli O127:H6 str. E2348/69 replication protein YP_002328779.1 1275829 D 574521 CDS YP_002328780.1 215486349 7064740 1276601..1276801 1 NC_011601.1 hypothetical protein 1276801 7064740 E2348C_1231 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328780.1 1276601 D 574521 CDS YP_002328781.1 215486350 7064741 1277241..1278083 1 NC_011601.1 hypothetical protein 1278083 7064741 E2348C_1232 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328781.1 1277241 D 574521 CDS YP_002328782.1 215486351 7064743 1279122..1280495 1 NC_011601.1 ATP-binding protein 1280495 7064743 E2348C_1234 Escherichia coli O127:H6 str. E2348/69 ATP-binding protein YP_002328782.1 1279122 D 574521 CDS YP_002328783.1 215486352 7064744 1280482..1281117 1 NC_011601.1 HNH endonuclease 1281117 7064744 E2348C_1235 Escherichia coli O127:H6 str. E2348/69 HNH endonuclease YP_002328783.1 1280482 D 574521 CDS YP_002328784.1 215486353 7064745 complement(1281372..1282460) 1 NC_011601.1 transposase 1282460 7064745 E2348C_1236 Escherichia coli O127:H6 str. E2348/69 transposase YP_002328784.1 1281372 R 574521 CDS YP_002328785.1 215486354 7064747 1282907..1283155 1 NC_011601.1 hypothetical protein 1283155 7064747 E2348C_1238 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328785.1 1282907 D 574521 CDS YP_002328786.1 215486355 7064748 1283222..1283500 1 NC_011601.1 hypothetical protein 1283500 7064748 E2348C_1239 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328786.1 1283222 D 574521 CDS YP_002328787.1 215486356 7064749 1283502..1284560 1 NC_011601.1 hypothetical protein 1284560 7064749 E2348C_1240 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328787.1 1283502 D 574521 CDS YP_002328788.1 215486357 7064750 1284561..1284926 1 NC_011601.1 crossover junction endodeoxyribonuclease 1284926 7064750 E2348C_1241 Escherichia coli O127:H6 str. E2348/69 crossover junction endodeoxyribonuclease YP_002328788.1 1284561 D 574521 CDS YP_002328789.1 215486358 7064751 1284935..1285477 1 NC_011601.1 hypothetical protein 1285477 7064751 E2348C_1242 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328789.1 1284935 D 574521 CDS YP_002328790.1 215486359 7064752 1285755..1285988 1 NC_011601.1 hypothetical protein 1285988 7064752 E2348C_1243 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328790.1 1285755 D 574521 CDS YP_002328791.1 215486360 7064753 1286139..1287188 1 NC_011601.1 DNA methylase 1287188 7064753 E2348C_1244 Escherichia coli O127:H6 str. E2348/69 DNA methylase YP_002328791.1 1286139 D 574521 CDS YP_002328792.1 215486361 7062248 complement(1288384..1288719) 1 NC_011601.1 hypothetical protein 1288719 7062248 E2348C_1245 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328792.1 1288384 R 574521 CDS YP_002328793.1 215486362 7064755 1288980..1290830 1 NC_011601.1 hypothetical protein 1290830 7064755 E2348C_1246 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328793.1 1288980 D 574521 CDS YP_002328794.1 215486363 7064984 1291265..1292638 1 NC_011601.1 transposase of ISEc13 1292638 7064984 E2348C_1247 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002328794.1 1291265 D 574521 CDS YP_002328795.1 215486364 7064985 1292776..1293234 1 NC_011601.1 transposase of IS200C 1293234 7064985 E2348C_1248 Escherichia coli O127:H6 str. E2348/69 transposase of IS200C YP_002328795.1 1292776 D 574521 CDS YP_002328796.1 215486365 7064756 1293394..1293600 1 NC_011601.1 holin protein 1293600 7064756 E2348C_1249 Escherichia coli O127:H6 str. E2348/69 holin protein YP_002328796.1 1293394 D 574521 CDS YP_002328797.1 215486366 7064757 1293600..1294097 1 NC_011601.1 endolysin 1294097 7064757 E2348C_1250 Escherichia coli O127:H6 str. E2348/69 endolysin YP_002328797.1 1293600 D 574521 CDS YP_002328798.1 215486367 7064758 1294094..1294531 1 NC_011601.1 endopeptidase 1294531 7064758 E2348C_1251 Escherichia coli O127:H6 str. E2348/69 endopeptidase YP_002328798.1 1294094 D 574521 CDS YP_002328799.1 215486368 7064759 1294293..1294478 1 NC_011601.1 lipoprotein Rz1 1294478 7064759 E2348C_1252 Escherichia coli O127:H6 str. E2348/69 lipoprotein Rz1 YP_002328799.1 1294293 D 574521 CDS YP_002328800.1 215486369 7064760 1295554..1295880 1 NC_011601.1 TonB-like protein 1295880 7064760 E2348C_1253 Escherichia coli O127:H6 str. E2348/69 TonB-like protein YP_002328800.1 1295554 D 574521 CDS YP_002328801.1 215486370 7064761 1296572..1297120 1 NC_011601.1 terminase small subunit 1297120 7064761 E2348C_1254 Escherichia coli O127:H6 str. E2348/69 terminase small subunit YP_002328801.1 1296572 D 574521 CDS YP_002328802.1 215486371 7064762 1297092..1299020 1 NC_011601.1 terminase large subunit 1299020 7064762 E2348C_1255 Escherichia coli O127:H6 str. E2348/69 terminase large subunit YP_002328802.1 1297092 D 574521 CDS YP_002328803.1 215486372 7064763 1299004..1299210 1 NC_011601.1 head-tail joining protein 1299210 7064763 E2348C_1256 Escherichia coli O127:H6 str. E2348/69 head-tail joining protein YP_002328803.1 1299004 D 574521 CDS YP_002328804.1 215486373 7064069 1299207..1300799 1 NC_011601.1 portal protein 1300799 7064069 E2348C_1257 Escherichia coli O127:H6 str. E2348/69 portal protein YP_002328804.1 1299207 D 574521 CDS YP_002328805.1 215486374 7064151 1301135..1301782 1 NC_011601.1 tail assembly protein 1301782 7064151 E2348C_1259 Escherichia coli O127:H6 str. E2348/69 tail assembly protein YP_002328805.1 1301135 D 574521 CDS YP_002328806.1 215486375 7064152 1301843..1305256 1 NC_011601.1 host specificity protein 1305256 7064152 E2348C_1260 Escherichia coli O127:H6 str. E2348/69 host specificity protein YP_002328806.1 1301843 D 574521 CDS YP_002328807.1 215486376 7064153 1305326..1305925 1 NC_011601.1 outer membrane precursor Lom 1305925 7064153 E2348C_1261 Escherichia coli O127:H6 str. E2348/69 outer membrane precursor Lom YP_002328807.1 1305326 D 574521 CDS YP_002328808.1 215486377 7064154 1305990..1307303 1 NC_011601.1 side tail fiber protein 1307303 7064154 E2348C_1262 Escherichia coli O127:H6 str. E2348/69 side tail fiber protein YP_002328808.1 1305990 D 574521 CDS YP_002328809.1 215486378 7064155 1307305..1307574 1 NC_011601.1 hypothetical protein 1307574 7064155 E2348C_1263 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328809.1 1307305 D 574521 CDS YP_002328810.1 215486379 7064157 complement(1308740..1309603) 1 NC_011601.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 1309603 potB 7064157 potB Escherichia coli O127:H6 str. E2348/69 spermidine/putrescine ABC transporter membrane protein YP_002328810.1 1308740 R 574521 CDS YP_002328811.1 215486380 7060771 complement(1309587..1310723) 1 NC_011601.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase 1310723 potA 7060771 potA Escherichia coli O127:H6 str. E2348/69 putrescine/spermidine ABC transporter ATPase YP_002328811.1 1309587 R 574521 CDS YP_002328812.1 215486381 7060770 1310973..1312199 1 NC_011601.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1312199 pepT 7060770 pepT Escherichia coli O127:H6 str. E2348/69 peptidase T YP_002328812.1 1310973 D 574521 CDS YP_002328813.1 215486382 7060705 complement(1312248..1313369) 1 NC_011601.1 hypothetical protein 1313369 ycfD 7060705 ycfD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328813.1 1312248 R 574521 CDS YP_002328814.1 215486383 7061454 complement(1313445..1314905) 1 NC_011601.1 sensor protein PhoQ 1314905 phoQ 7061454 phoQ Escherichia coli O127:H6 str. E2348/69 sensor protein PhoQ YP_002328814.1 1313445 R 574521 CDS YP_002328815.1 215486384 7060747 complement(1314905..1315576) 1 NC_011601.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 1315576 phoP 7060747 phoP Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator PhoP YP_002328815.1 1314905 R 574521 CDS YP_002328816.1 215486385 7060746 complement(1315746..1317116) 1 NC_011601.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1317116 purB 7060746 purB Escherichia coli O127:H6 str. E2348/69 adenylosuccinate lyase YP_002328816.1 1315746 R 574521 CDS YP_002328817.1 215486386 7063912 complement(1317120..1317761) 1 NC_011601.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1317761 hflD 7063912 hflD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328817.1 1317120 R 574521 CDS YP_002328818.1 215486387 7064306 complement(1317797..1318903) 1 NC_011601.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1318903 mnmA 7064306 mnmA Escherichia coli O127:H6 str. E2348/69 tRNA-specific 2-thiouridylase MnmA YP_002328818.1 1317797 R 574521 CDS YP_002328819.1 215486388 7063799 complement(1318957..1319418) 1 NC_011601.1 bifunctional thiamin pyrimidine pyrophosphate hydrolase/thiamin pyrophosphate hydrolase 1319418 nudJ 7063799 nudJ Escherichia coli O127:H6 str. E2348/69 bifunctional thiamin pyrimidine pyrophosphate hydrolase/thiamin pyrophosphate hydrolase YP_002328819.1 1318957 R 574521 CDS YP_002328820.1 215486389 7065434 complement(1319428..1320081) 1 NC_011601.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 1320081 rluE 7065434 rluE Escherichia coli O127:H6 str. E2348/69 23S rRNA pseudouridine synthase E YP_002328820.1 1319428 R 574521 CDS YP_002328821.1 215486390 7060842 1320254..1321504 1 NC_011601.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1321504 icd 7060842 icd Escherichia coli O127:H6 str. E2348/69 isocitrate dehydrogenase YP_002328821.1 1320254 D 574521 CDS YP_002328822.1 215486391 7063517 complement(1321766..1322170) 1 NC_011601.1 hypothetical protein 1322170 ycgX 7063517 ycgX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328822.1 1321766 R 574521 CDS YP_002328823.1 215486392 7061476 complement(1322391..1323122) 1 NC_011601.1 DNA-binding transcriptional regulator 1323122 ycgE 7061476 ycgE Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002328823.1 1322391 R 574521 CDS YP_002328824.1 215486393 7061465 complement(1323327..1324538) 1 NC_011601.1 FAD-binding phosphodiesterase 1324538 ycgF 7061465 ycgF Escherichia coli O127:H6 str. E2348/69 FAD-binding phosphodiesterase YP_002328824.1 1323327 R 574521 CDS YP_002328825.1 215486394 7061466 1324852..1325088 1 NC_011601.1 hypothetical protein 1325088 ycgZ 7061466 ycgZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328825.1 1324852 D 574521 CDS YP_002328826.1 215486395 7061477 1325131..1325403 1 NC_011601.1 hypothetical protein 1325403 ymgA 7061477 ymgA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328826.1 1325131 D 574521 CDS YP_002328827.1 215486396 7062027 1325432..1325698 1 NC_011601.1 hypothetical protein 1325698 ymgB 7062027 ymgB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328827.1 1325432 D 574521 CDS YP_002328828.1 215486397 7062028 1325811..1326059 1 NC_011601.1 hypothetical protein 1326059 ymgC 7062028 ymgC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328828.1 1325811 D 574521 CDS YP_002328829.1 215486398 7061467 1327381..1327599 1 NC_011601.1 hypothetical protein 1327599 ymgF 7061467 ymgF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328829.1 1327381 D 574521 CDS YP_002328830.1 215486399 7061468 complement(1329573..1329902) 1 NC_011601.1 hypothetical protein 1329902 ymgD 7061468 ymgD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328830.1 1329573 R 574521 CDS YP_002328831.1 215486400 7062030 complement(1329912..1330256) 1 NC_011601.1 hypothetical protein 1330256 ymgG 7062030 ymgG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328831.1 1329912 R 574521 CDS YP_002328832.1 215486401 7062033 complement(1330258..1330431) 1 NC_011601.1 hypothetical protein 1330431 ymgI 7062033 ymgI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328832.1 1330258 R 574521 CDS YP_002328833.1 215486402 7062034 1330532..1330717 1 NC_011601.1 coserved protein 1330717 ymgJ 7062034 ymgJ Escherichia coli O127:H6 str. E2348/69 coserved protein YP_002328833.1 1330532 D 574521 CDS YP_002328834.1 215486403 7061469 complement(1331546..1331812) 1 NC_011601.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1331812 minE 7061469 minE Escherichia coli O127:H6 str. E2348/69 cell division topological specificity factor MinE YP_002328834.1 1331546 R 574521 CDS YP_002328835.1 215486404 7063790 complement(1331816..1332628) 1 NC_011601.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1332628 minD 7063790 minD Escherichia coli O127:H6 str. E2348/69 cell division inhibitor MinD YP_002328835.1 1331816 R 574521 CDS YP_002328836.1 215486405 7063789 complement(1332652..1333347) 1 NC_011601.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 1333347 minC 7063789 minC Escherichia coli O127:H6 str. E2348/69 septum formation inhibitor YP_002328836.1 1332652 R 574521 CDS YP_002328837.1 215486406 7063788 1333867..1334235 1 NC_011601.1 hypothetical protein 1334235 ycgJ 7063788 ycgJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328837.1 1333867 D 574521 CDS YP_002328838.1 215486407 7061470 complement(1334338..1334739) 1 NC_011601.1 hypothetical protein 1334739 ycgK 7061470 ycgK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328838.1 1334338 R 574521 CDS YP_002328839.1 215486408 7061471 1334981..1335274 1 NC_011601.1 hypothetical protein 1335274 ycgL 7061471 ycgL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328839.1 1334981 D 574521 CDS YP_002328840.1 215486409 7061472 1335346..1336005 1 NC_011601.1 hypothetical protein 1336005 ycgM 7061472 ycgM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328840.1 1335346 D 574521 CDS YP_002328841.1 215486410 7061473 1336097..1336543 1 NC_011601.1 hypothetical protein 1336543 ycgN 7061473 ycgN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328841.1 1336097 D 574521 CDS YP_002328842.1 215486411 7061144 1337336..1337755 1 NC_011601.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1337755 umuD 7061144 umuD Escherichia coli O127:H6 str. E2348/69 DNA polymerase V subunit UmuD YP_002328842.1 1337336 D 574521 CDS YP_002328843.1 215486412 7062325 1337755..1339023 1 NC_011601.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1339023 umuC 7062325 umuC Escherichia coli O127:H6 str. E2348/69 DNA polymerase V subunit UmuC YP_002328843.1 1337755 D 574521 CDS YP_002328844.1 215486413 7062324 complement(1339068..1339598) 1 NC_011601.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1339598 dsbB 7062324 dsbB Escherichia coli O127:H6 str. E2348/69 disulfide bond formation protein B YP_002328844.1 1339068 R 574521 CDS YP_002328845.1 215486414 7065063 complement(1339744..1341285) 1 NC_011601.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1341285 nhaB 7065063 nhaB Escherichia coli O127:H6 str. E2348/69 sodium/proton antiporter YP_002328845.1 1339744 R 574521 CDS YP_002328846.1 215486415 7065388 1341507..1342226 1 NC_011601.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1342226 fadR 7065388 fadR Escherichia coli O127:H6 str. E2348/69 fatty acid metabolism regulator YP_002328846.1 1341507 D 574521 CDS YP_002328847.1 215486416 7062080 complement(1342277..1343809) 1 NC_011601.1 SpoVR family protein 1343809 ycgB 7062080 ycgB Escherichia coli O127:H6 str. E2348/69 SpoVR family protein YP_002328847.1 1342277 R 574521 CDS YP_002328848.1 215486417 7061464 1344139..1345437 1 NC_011601.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1345437 dadA 7061464 dadA Escherichia coli O127:H6 str. E2348/69 D-amino acid dehydrogenase small subunit YP_002328848.1 1344139 D 574521 CDS YP_002328849.1 215486418 7065216 1345447..1346517 1 NC_011601.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1346517 dadX 7065216 dadX Escherichia coli O127:H6 str. E2348/69 alanine racemase YP_002328849.1 1345447 D 574521 CDS YP_002328850.1 215486419 7065217 complement(1346574..1348310) 1 NC_011601.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1348310 cvrA 7065217 cvrA Escherichia coli O127:H6 str. E2348/69 potassium/proton antiporter YP_002328850.1 1346574 R 574521 CDS YP_002328851.1 215486420 7065178 complement(1348405..1349319) 1 NC_011601.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1349319 ldcA 7065178 ldcA Escherichia coli O127:H6 str. E2348/69 L,D-carboxypeptidase A YP_002328851.1 1348405 R 574521 CDS YP_002328852.1 215486421 7061512 1349419..1350030 1 NC_011601.1 lytic murein endotransglycosylase E 1350030 emtA 7061512 emtA Escherichia coli O127:H6 str. E2348/69 lytic murein endotransglycosylase E YP_002328852.1 1349419 D 574521 CDS YP_002328853.1 215486422 7063849 complement(1350032..1350766) 1 NC_011601.1 protein involved in flagellar function 1350766 ycgR 7063849 ycgR Escherichia coli O127:H6 str. E2348/69 protein involved in flagellar function YP_002328853.1 1350032 R 574521 CDS YP_002328854.1 215486423 7061475 1350967..1351221 1 NC_011601.1 hypothetical protein 1351221 ymgE 7061475 ymgE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328854.1 1350967 D 574521 CDS YP_002328855.1 215486424 7062031 complement(1351271..1353241) 1 NC_011601.1 TonB dependent outer membrane receptor 1353241 7062031 E2348C_1315 Escherichia coli O127:H6 str. E2348/69 TonB dependent outer membrane receptor YP_002328855.1 1351271 R 574521 CDS YP_002328856.1 215486425 7064158 complement(1353267..1354121) 1 NC_011601.1 involved in molybdenum transport; molybdenum transport protein ModD 1354121 7064158 E2348C_1316 Escherichia coli O127:H6 str. E2348/69 molybdenum transport protein ModD YP_002328856.1 1353267 R 574521 CDS YP_002328857.1 215486426 7064159 complement(1354118..1354930) 1 NC_011601.1 hypothetical protein 1354930 7064159 E2348C_1317 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328857.1 1354118 R 574521 CDS YP_002328858.1 215486427 7064160 complement(1354940..1355698) 1 NC_011601.1 ferric enterobactin transport ATP-binding protein 1355698 7064160 E2348C_1318 Escherichia coli O127:H6 str. E2348/69 ferric enterobactin transport ATP-binding protein YP_002328858.1 1354940 R 574521 CDS YP_002328859.1 215486428 7064161 complement(1355695..1356675) 1 NC_011601.1 ABC transporter permease 1356675 7064161 E2348C_1319 Escherichia coli O127:H6 str. E2348/69 ABC transporter permease YP_002328859.1 1355695 R 574521 CDS YP_002328860.1 215486429 7064162 complement(1356675..1357697) 1 NC_011601.1 ABC transporter ATP-binding protein 1357697 7064162 E2348C_1320 Escherichia coli O127:H6 str. E2348/69 ABC transporter ATP-binding protein YP_002328860.1 1356675 R 574521 CDS YP_002328861.1 215486430 7064163 complement(1358034..1359731) 1 NC_011601.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase 1359731 treA 7064163 treA Escherichia coli O127:H6 str. E2348/69 trehalase YP_002328861.1 1358034 R 574521 CDS YP_002328862.1 215486431 7062233 complement(1360051..1361469) 1 NC_011601.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit DhaM 1361469 dhaM 7062233 dhaM Escherichia coli O127:H6 str. E2348/69 dihydroxyacetone kinase subunit DhaM YP_002328862.1 1360051 R 574521 CDS YP_002328863.1 215486432 7065023 complement(1361480..1362112) 1 NC_011601.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL 1362112 dhaL 7065023 dhaL Escherichia coli O127:H6 str. E2348/69 dihydroxyacetone kinase subunit DhaL YP_002328863.1 1361480 R 574521 CDS YP_002328864.1 215486433 7065022 complement(1362123..1363193) 1 NC_011601.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 1363193 dhaK 7065022 dhaK Escherichia coli O127:H6 str. E2348/69 dihydroxyacetone kinase subunit DhaK YP_002328864.1 1362123 R 574521 CDS YP_002328865.1 215486434 7065021 1363423..1365342 1 NC_011601.1 Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1365342 dhaR 7065021 dhaR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator DhaR YP_002328865.1 1363423 D 574521 CDS YP_002328866.1 215486435 7065024 complement(1365747..1366838) 1 NC_011601.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1366838 ychF 7065024 ychF Escherichia coli O127:H6 str. E2348/69 GTP-dependent nucleic acid-binding protein EngD YP_002328866.1 1365747 R 574521 CDS YP_002328867.1 215486436 7061480 complement(1366955..1367539) 1 NC_011601.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1367539 pth 7061480 pth Escherichia coli O127:H6 str. E2348/69 peptidyl-tRNA hydrolase YP_002328867.1 1366955 R 574521 CDS YP_002328868.1 215486437 7061334 1367817..1368095 1 NC_011601.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1368095 ychH 7061334 ychH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328868.1 1367817 D 574521 CDS YP_002328869.1 215486438 7061481 complement(1368150..1369829) 1 NC_011601.1 role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM 1369829 ychM 7061481 ychM Escherichia coli O127:H6 str. E2348/69 sulfate transporter YchM YP_002328869.1 1368150 R 574521 CDS YP_002328870.1 215486439 7061483 complement(1369954..1370901) 1 NC_011601.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1370901 prs 7061483 prs Escherichia coli O127:H6 str. E2348/69 ribose-phosphate pyrophosphokinase YP_002328870.1 1369954 R 574521 CDS YP_002328871.1 215486440 7061314 complement(1371052..1371903) 1 NC_011601.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1371903 ipk 7061314 ipk Escherichia coli O127:H6 str. E2348/69 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_002328871.1 1371052 R 574521 CDS YP_002328872.1 215486441 7063554 complement(1371903..1372526) 1 NC_011601.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; molecular chaperone LolB 1372526 lolB 7063554 lolB Escherichia coli O127:H6 str. E2348/69 molecular chaperone LolB YP_002328872.1 1371903 R 574521 CDS YP_002328873.1 215486442 7061555 1372740..1373996 1 NC_011601.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1373996 hemA 7061555 hemA Escherichia coli O127:H6 str. E2348/69 glutamyl-tRNA reductase YP_002328873.1 1372740 D 574521 CDS YP_002328874.1 215486443 7064291 1374038..1375120 1 NC_011601.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1375120 prfA 7064291 prfA Escherichia coli O127:H6 str. E2348/69 peptide chain release factor 1 YP_002328874.1 1374038 D 574521 CDS YP_002328875.1 215486444 7061284 1375120..1375953 1 NC_011601.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1375953 prmC 7061284 prmC Escherichia coli O127:H6 str. E2348/69 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_002328875.1 1375120 D 574521 CDS YP_002328876.1 215486445 7061295 1375950..1376342 1 NC_011601.1 transcriptional regulator 1376342 ychQ 7061295 ychQ Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002328876.1 1375950 D 574521 CDS YP_002328877.1 215486446 7061486 1376346..1377155 1 NC_011601.1 transcriptional regulator 1377155 ychA 7061486 ychA Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002328877.1 1376346 D 574521 CDS YP_002328878.1 215486447 7061478 1377191..1378045 1 NC_011601.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1378045 kdsA 7061478 kdsA Escherichia coli O127:H6 str. E2348/69 2-dehydro-3-deoxyphosphooctonate aldolase YP_002328878.1 1377191 D 574521 CDS YP_002328879.1 215486448 7063578 complement(1378194..1378301) 1 NC_011601.1 toxic polypeptide, small 1378301 ldrA 7063578 ldrA Escherichia coli O127:H6 str. E2348/69 toxic polypeptide, small YP_002328879.1 1378194 R 574521 CDS YP_002328880.1 215486449 7063971 complement(1378706..1379806) 1 NC_011601.1 calcium/sodium:proton antiporter 1379806 chaA 7063971 chaA Escherichia coli O127:H6 str. E2348/69 calcium/sodium:proton antiporter YP_002328880.1 1378706 R 574521 CDS YP_002328881.1 215486450 7064350 1380076..1380306 1 NC_011601.1 in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1380306 chaB 7064350 chaB Escherichia coli O127:H6 str. E2348/69 cation transport regulator YP_002328881.1 1380076 D 574521 CDS YP_002328882.1 215486451 7064351 1380464..1381159 1 NC_011601.1 regulatory protein for cation transport 1381159 chaC 7064351 chaC Escherichia coli O127:H6 str. E2348/69 regulatory protein for cation transport YP_002328882.1 1380464 D 574521 CDS YP_002328883.1 215486452 7064352 complement(1381203..1381556) 1 NC_011601.1 hypothetical protein 1381556 ychN 7064352 ychN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328883.1 1381203 R 574521 CDS YP_002328884.1 215486453 7061484 1381741..1383135 1 NC_011601.1 hypothetical protein 1383135 ychO 7061484 ychO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328884.1 1381741 D 574521 CDS YP_002328885.1 215486454 7061485 complement(1383136..1383786) 1 NC_011601.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 1383786 narL 7061485 narL Escherichia coli O127:H6 str. E2348/69 transcriptional regulator NarL YP_002328885.1 1383136 R 574521 CDS YP_002328886.1 215486455 7060936 complement(1383779..1385575) 1 NC_011601.1 nitrate/nitrite sensor protein NarX 1385575 narX 7060936 narX Escherichia coli O127:H6 str. E2348/69 nitrate/nitrite sensor protein NarX YP_002328886.1 1383779 R 574521 CDS YP_002328887.1 215486456 7065373 1385914..1387305 1 NC_011601.1 nitrate/nitrite transporter 1387305 narK 7065373 narK Escherichia coli O127:H6 str. E2348/69 nitrate/nitrite transporter YP_002328887.1 1385914 D 574521 CDS YP_002328888.1 215486457 7060935 1387698..1391441 1 NC_011601.1 nitrate reductase 1 subunit alpha 1391441 narG 7060935 narG Escherichia coli O127:H6 str. E2348/69 nitrate reductase 1 subunit alpha YP_002328888.1 1387698 D 574521 CDS YP_002328889.1 215486458 7060931 1391438..1392976 1 NC_011601.1 nitrate reductase 1 subunit, beta (Fe-S) 1392976 narH 7060931 narH Escherichia coli O127:H6 str. E2348/69 nitrate reductase 1 subunit, beta (Fe-S) YP_002328889.1 1391438 D 574521 CDS YP_002328890.1 215486459 7060932 1392973..1393683 1 NC_011601.1 molybdenum-cofactor-assembly chaperone subunit (delta subunit) of nitrate reductase 1 1393683 narJ 7060932 narJ Escherichia coli O127:H6 str. E2348/69 molybdenum-cofactor-assembly chaperone subunit (delta subunit) of nitrate reductase 1 YP_002328890.1 1392973 D 574521 CDS YP_002328891.1 215486460 7060934 1393683..1394360 1 NC_011601.1 nitrate reductase 1 subunit gamma (cytochrome b(NR)) 1394360 narI 7060934 narI Escherichia coli O127:H6 str. E2348/69 nitrate reductase 1 subunit gamma (cytochrome b(NR)) YP_002328891.1 1393683 D 574521 CDS YP_002328892.1 215486461 7060933 1394472..1395479 1 NC_011601.1 hypothetical protein 1395479 7060933 E2348C_1352 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328892.1 1394472 D 574521 CDS YP_002328893.1 215486462 7064164 1395476..1396492 1 NC_011601.1 dehydrogenase 1396492 7064164 E2348C_1353 Escherichia coli O127:H6 str. E2348/69 dehydrogenase YP_002328893.1 1395476 D 574521 CDS YP_002328894.1 215486463 7064165 1396470..1397276 1 NC_011601.1 hypothetical protein 1397276 7064165 E2348C_1354 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328894.1 1396470 D 574521 CDS YP_002328895.1 215486464 7064166 1397273..1398559 1 NC_011601.1 coenzyme F390 synthetase 1398559 7064166 E2348C_1355 Escherichia coli O127:H6 str. E2348/69 coenzyme F390 synthetase YP_002328895.1 1397273 D 574521 CDS YP_002328896.1 215486465 7064167 1398556..1399158 1 NC_011601.1 hypothetical protein 1399158 7064167 E2348C_1356 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328896.1 1398556 D 574521 CDS YP_002328897.1 215486466 7064168 1399151..1400275 1 NC_011601.1 hypothetical protein 1400275 7064168 E2348C_1357 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328897.1 1399151 D 574521 CDS YP_002328898.1 215486467 7064169 1400262..1401353 1 NC_011601.1 hypothetical protein 1401353 7064169 E2348C_1358 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328898.1 1400262 D 574521 CDS YP_002328899.1 215486468 7062288 complement(1401614..1402456) 1 NC_011601.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1402456 purU 7062288 purU Escherichia coli O127:H6 str. E2348/69 formyltetrahydrofolate deformylase YP_002328899.1 1401614 R 574521 CDS YP_002328900.1 215486469 7063924 complement(1402506..1402964) 1 NC_011601.1 hypothetical protein 1402964 ychJ 7063924 ychJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328900.1 1402506 R 574521 CDS YP_002328901.1 215486470 7061482 1403038..1403982 1 NC_011601.1 hypothetical protein 1403982 rssA 7061482 rssA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328901.1 1403038 D 574521 CDS YP_002328902.1 215486471 7064562 1404074..1405087 1 NC_011601.1 response regulator of RpoS 1405087 rssB 7064562 rssB Escherichia coli O127:H6 str. E2348/69 response regulator of RpoS YP_002328902.1 1404074 D 574521 CDS YP_002328903.1 215486472 7064563 1405289..1406197 1 NC_011601.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 1406197 galU 7064563 galU Escherichia coli O127:H6 str. E2348/69 UTP-glucose-1-phosphate uridylyltransferase YP_002328903.1 1405289 D 574521 CDS YP_002328904.1 215486473 7061624 complement(1406341..1406754) 1 NC_011601.1 global DNA-binding transcriptional dual regulator H-NS 1406754 hns 7061624 hns Escherichia coli O127:H6 str. E2348/69 global DNA-binding transcriptional dual regulator H-NS YP_002328904.1 1406341 R 574521 CDS YP_002328905.1 215486474 7062160 1407358..1407975 1 NC_011601.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1407975 tdk 7062160 tdk Escherichia coli O127:H6 str. E2348/69 thymidine kinase YP_002328905.1 1407358 D 574521 CDS YP_002328906.1 215486475 7064171 complement(1409413..1412088) 1 NC_011601.1 bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1412088 adhE 7064171 adhE Escherichia coli O127:H6 str. E2348/69 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_002328906.1 1409413 R 574521 CDS YP_002328907.1 215486476 7062406 1412565..1413212 1 NC_011601.1 hypothetical protein 1413212 ychE 7062406 ychE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328907.1 1412565 D 574521 CDS YP_002328908.1 215486477 7061479 1413950..1415581 1 NC_011601.1 oligopeptide transporter subunit OppA 1415581 oppA 7061479 oppA Escherichia coli O127:H6 str. E2348/69 oligopeptide transporter subunit OppA YP_002328908.1 1413950 D 574521 CDS YP_002328909.1 215486478 7062883 1415667..1416587 1 NC_011601.1 oligopeptide transporter permease 1416587 oppB 7062883 oppB Escherichia coli O127:H6 str. E2348/69 oligopeptide transporter permease YP_002328909.1 1415667 D 574521 CDS YP_002328910.1 215486479 7062884 1416602..1417510 1 NC_011601.1 oligopeptide transporter subunit OppC 1417510 oppC 7062884 oppC Escherichia coli O127:H6 str. E2348/69 oligopeptide transporter subunit OppC YP_002328910.1 1416602 D 574521 CDS YP_002328911.1 215486480 7062885 1417522..1418535 1 NC_011601.1 oligopeptide ABC transporter ATP-binding protein 1418535 oppD 7062885 oppD Escherichia coli O127:H6 str. E2348/69 oligopeptide ABC transporter ATP-binding protein YP_002328911.1 1417522 D 574521 CDS YP_002328912.1 215486481 7062886 1418532..1419536 1 NC_011601.1 oligopeptide transporter subunit OppF, ATP-binding component of ABC superfamily 1419536 oppF 7062886 oppF Escherichia coli O127:H6 str. E2348/69 oligopeptide transporter subunit OppF, ATP-binding component of ABC superfamily YP_002328912.1 1418532 D 574521 CDS YP_002328913.1 215486482 7062887 complement(1419589..1419918) 1 NC_011601.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1419918 yciU 7062887 yciU Escherichia coli O127:H6 str. E2348/69 dsDNA-mimic protein YP_002328913.1 1419589 R 574521 CDS YP_002328914.1 215486483 7062946 complement(1419953..1421413) 1 NC_011601.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 1421413 cls 7062946 cls Escherichia coli O127:H6 str. E2348/69 cardiolipin synthetase YP_002328914.1 1419953 R 574521 CDS YP_002328915.1 215486484 7062813 1421556..1421729 1 NC_011601.1 hypothetical protein 1421729 yciY 7062813 yciY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328915.1 1421556 D 574521 CDS YP_002328916.1 215486485 7062950 complement(1421784..1423037) 1 NC_011601.1 voltage-gated potassium channel 1423037 kch 7062950 kch Escherichia coli O127:H6 str. E2348/69 voltage-gated potassium channel YP_002328916.1 1421784 R 574521 CDS YP_002328917.1 215486486 7063568 complement(1423337..1423633) 1 NC_011601.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the reactions based on sequence and structure similarity; hypothetical protein 1423633 yciI 7063568 yciI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328917.1 1423337 R 574521 CDS YP_002328918.1 215486487 7061491 1423857..1424579 1 NC_011601.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transporter 1424579 tonB 7061491 tonB Escherichia coli O127:H6 str. E2348/69 transporter YP_002328918.1 1423857 D 574521 CDS YP_002328919.1 215486488 7061817 complement(1424619..1425017) 1 NC_011601.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase of proteins; acyl-CoA thioester hydrolase 1425017 yciA 7061817 yciA Escherichia coli O127:H6 str. E2348/69 acyl-CoA thioester hydrolase YP_002328919.1 1424619 R 574521 CDS YP_002328920.1 215486489 7061487 complement(1425122..1425661) 1 NC_011601.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1425661 yciB 7061487 yciB Escherichia coli O127:H6 str. E2348/69 intracellular septation protein A YP_002328920.1 1425122 R 574521 CDS YP_002328921.1 215486490 7061488 complement(1425691..1426434) 1 NC_011601.1 hypothetical protein 1426434 yciC 7061488 yciC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328921.1 1425691 R 574521 CDS YP_002328922.1 215486491 7061489 1426791..1427429 1 NC_011601.1 receptor for colicin S4; outer membrane protein W 1427429 ompW 7061489 ompW Escherichia coli O127:H6 str. E2348/69 outer membrane protein W YP_002328922.1 1426791 D 574521 CDS YP_002328923.1 215486492 7061170 complement(1427475..1428605) 1 NC_011601.1 integrase 1428605 7061170 E2348C_1384 Escherichia coli O127:H6 str. E2348/69 integrase YP_002328923.1 1427475 R 574521 CDS YP_002328924.1 215486493 7064172 complement(1428583..1428831) 1 NC_011601.1 excisionase 1428831 7064172 E2348C_1385 Escherichia coli O127:H6 str. E2348/69 excisionase YP_002328924.1 1428583 R 574521 CDS YP_002328925.1 215486494 7064173 complement(1428896..1431367) 1 NC_011601.1 exonuclease 1431367 7064173 E2348C_1386 Escherichia coli O127:H6 str. E2348/69 exonuclease YP_002328925.1 1428896 R 574521 CDS YP_002328926.1 215486495 7064174 complement(1431460..1431651) 1 NC_011601.1 hypothetical protein 1431651 7064174 E2348C_1387 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328926.1 1431460 R 574521 CDS YP_002328927.1 215486496 7064175 complement(1431648..1431836) 1 NC_011601.1 cell division inhibition protein DicB 1431836 7064175 E2348C_1388 Escherichia coli O127:H6 str. E2348/69 cell division inhibition protein DicB YP_002328927.1 1431648 R 574521 CDS YP_002328928.1 215486497 7065027 1432395..1432673 1 NC_011601.1 hypothetical protein 1432673 7065027 E2348C_1389 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328928.1 1432395 D 574521 CDS YP_002328929.1 215486498 7064177 complement(1432633..1433034) 1 NC_011601.1 hypothetical protein 1433034 7064177 E2348C_1390 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328929.1 1432633 R 574521 CDS YP_002328930.1 215486499 7064178 complement(1433046..1433279) 1 NC_011601.1 hypothetical protein 1433279 7064178 E2348C_1391 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328930.1 1433046 R 574521 CDS YP_002328931.1 215486500 7064179 complement(1433464..1433883) 1 NC_011601.1 phage repressor protein 1433883 7064179 E2348C_1392 Escherichia coli O127:H6 str. E2348/69 phage repressor protein YP_002328931.1 1433464 R 574521 CDS YP_002328932.1 215486501 7064180 1433984..1434265 1 NC_011601.1 hypothetical protein 1434265 7064180 E2348C_1393 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328932.1 1433984 D 574521 CDS YP_002328933.1 215486502 7064181 1434249..1434674 1 NC_011601.1 phage regulatory protein 1434674 7064181 E2348C_1394 Escherichia coli O127:H6 str. E2348/69 phage regulatory protein YP_002328933.1 1434249 D 574521 CDS YP_002328934.1 215486503 7064182 1434697..1435659 1 NC_011601.1 replication protein 1435659 7064182 E2348C_1395 Escherichia coli O127:H6 str. E2348/69 replication protein YP_002328934.1 1434697 D 574521 CDS YP_002328935.1 215486504 7064183 1435700..1436122 1 NC_011601.1 hypothetical protein 1436122 7064183 E2348C_1396 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328935.1 1435700 D 574521 CDS YP_002328936.1 215486505 7064184 1436366..1436677 1 NC_011601.1 hypothetical protein 1436677 7064184 E2348C_1397 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328936.1 1436366 D 574521 CDS YP_002328937.1 215486506 7064185 1436978..1437331 1 NC_011601.1 antitermination protein 1437331 7064185 E2348C_1398 Escherichia coli O127:H6 str. E2348/69 antitermination protein YP_002328937.1 1436978 D 574521 CDS YP_002328938.1 215486507 7064186 complement(1437328..1437969) 1 NC_011601.1 hypothetical protein 1437969 7064186 E2348C_1399 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328938.1 1437328 R 574521 CDS YP_002328939.1 215486508 7064187 complement(1437962..1438390) 1 NC_011601.1 hypothetical protein 1438390 7064187 E2348C_1400 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328939.1 1437962 R 574521 CDS YP_002328940.1 215486509 7064188 complement(1438387..1439478) 1 NC_011601.1 hypothetical protein 1439478 7064188 E2348C_1401 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328940.1 1438387 R 574521 CDS YP_002328941.1 215486510 7064189 1439768..1439980 1 NC_011601.1 prophage maintenance protein 1439980 7064189 E2348C_1402 Escherichia coli O127:H6 str. E2348/69 prophage maintenance protein YP_002328941.1 1439768 D 574521 CDS YP_002328942.1 215486511 7064190 1439825..1439980 1 NC_011601.1 host killing protein 1439980 7064190 E2348C_1403 Escherichia coli O127:H6 str. E2348/69 host killing protein YP_002328942.1 1439825 D 574521 CDS YP_002328943.1 215486512 7064191 1440147..1440425 1 NC_011601.1 hypothetical protein 1440425 7064191 E2348C_1404 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328943.1 1440147 D 574521 CDS YP_002328944.1 215486513 7064192 1440427..1441476 1 NC_011601.1 hypothetical protein 1441476 7064192 E2348C_1405 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328944.1 1440427 D 574521 CDS YP_002328945.1 215486514 7064193 1441489..1441848 1 NC_011601.1 crossover junction endodeoxyribonuclease 1441848 7064193 E2348C_1406 Escherichia coli O127:H6 str. E2348/69 crossover junction endodeoxyribonuclease YP_002328945.1 1441489 D 574521 CDS YP_002328946.1 215486515 7064194 1441845..1442534 1 NC_011601.1 antitermination protein 1442534 7064194 E2348C_1407 Escherichia coli O127:H6 str. E2348/69 antitermination protein YP_002328946.1 1441845 D 574521 CDS YP_002328947.1 215486516 7064988 complement(1443111..1444484) 1 NC_011601.1 transposase of ISEc13 1444484 7064988 E2348C_1408 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002328947.1 1443111 R 574521 CDS YP_002328948.1 215486517 7064196 1445019..1446872 1 NC_011601.1 hypothetical protein 1446872 7064196 E2348C_1409 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328948.1 1445019 D 574521 CDS YP_002328949.1 215486518 7064197 1447023..1447238 1 NC_011601.1 holin protein 1447238 7064197 E2348C_1410 Escherichia coli O127:H6 str. E2348/69 holin protein YP_002328949.1 1447023 D 574521 CDS YP_002328950.1 215486519 7064198 1447243..1447593 1 NC_011601.1 hypothetical protein 1447593 7064198 E2348C_1411 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328950.1 1447243 D 574521 CDS YP_002328951.1 215486520 7064199 1447657..1448190 1 NC_011601.1 endolysin 1448190 7064199 E2348C_1412 Escherichia coli O127:H6 str. E2348/69 endolysin YP_002328951.1 1447657 D 574521 CDS YP_002328952.1 215486521 7064200 1448346..1448480 1 NC_011601.1 hypothetical protein 1448480 7064200 E2348C_1413 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328952.1 1448346 D 574521 CDS YP_002328953.1 215486522 7064201 1448518..1448733 1 NC_011601.1 hypothetical protein 1448733 7064201 E2348C_1414 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328953.1 1448518 D 574521 CDS YP_002328954.1 215486523 7064202 1448833..1449327 1 NC_011601.1 endopeptidase 1449327 7064202 E2348C_1415 Escherichia coli O127:H6 str. E2348/69 endopeptidase YP_002328954.1 1448833 D 574521 CDS YP_002328955.1 215486524 7064203 1449053..1449238 1 NC_011601.1 lipoprotein Rz1 1449238 7064203 E2348C_1416 Escherichia coli O127:H6 str. E2348/69 lipoprotein Rz1 YP_002328955.1 1449053 D 574521 CDS YP_002328956.1 215486525 7064204 1449324..1449548 1 NC_011601.1 hypothetical protein 1449548 7064204 E2348C_1417 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328956.1 1449324 D 574521 CDS YP_002328957.1 215486526 7064205 complement(1449747..1449947) 1 NC_011601.1 hypothetical protein 1449947 7064205 E2348C_1418 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328957.1 1449747 R 574521 CDS YP_002328958.1 215486527 7064206 1449989..1450354 1 NC_011601.1 DNase 1450354 7064206 E2348C_1419 Escherichia coli O127:H6 str. E2348/69 DNase YP_002328958.1 1449989 D 574521 CDS YP_002328959.1 215486528 7064207 1450645..1451208 1 NC_011601.1 terminase small subunit 1451208 7064207 E2348C_1420 Escherichia coli O127:H6 str. E2348/69 terminase small subunit YP_002328959.1 1450645 D 574521 CDS YP_002328960.1 215486529 7064208 1451205..1452866 1 NC_011601.1 terminase large subunit 1452866 7064208 E2348C_1421 Escherichia coli O127:H6 str. E2348/69 terminase large subunit YP_002328960.1 1451205 D 574521 CDS YP_002328961.1 215486530 7064209 1452930..1454867 1 NC_011601.1 head protein/prohead protease 1454867 7064209 E2348C_1422 Escherichia coli O127:H6 str. E2348/69 head protein/prohead protease YP_002328961.1 1452930 D 574521 CDS YP_002328962.1 215486531 7064210 1454912..1455133 1 NC_011601.1 hypothetical protein 1455133 7064210 E2348C_1423 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328962.1 1454912 D 574521 CDS YP_002328963.1 215486532 7064211 1455079..1457664 1 NC_011601.1 portal protein 1457664 7064211 E2348C_1424 Escherichia coli O127:H6 str. E2348/69 portal protein YP_002328963.1 1455079 D 574521 CDS YP_002328964.1 215486533 7064212 1457661..1457987 1 NC_011601.1 DNA packaging protein 1457987 7064212 E2348C_1425 Escherichia coli O127:H6 str. E2348/69 DNA packaging protein YP_002328964.1 1457661 D 574521 CDS YP_002328965.1 215486534 7064213 1457997..1458347 1 NC_011601.1 head-tail adapotor 1458347 7064213 E2348C_1426 Escherichia coli O127:H6 str. E2348/69 head-tail adapotor YP_002328965.1 1457997 D 574521 CDS YP_002328966.1 215486535 7064214 1458344..1458790 1 NC_011601.1 minor tail protein 1458790 7064214 E2348C_1427 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328966.1 1458344 D 574521 CDS YP_002328967.1 215486536 7064215 1458787..1459131 1 NC_011601.1 minor tail protein 1459131 7064215 E2348C_1428 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328967.1 1458787 D 574521 CDS YP_002328968.1 215486537 7064216 1459196..1459912 1 NC_011601.1 major tail protein 1459912 7064216 E2348C_1429 Escherichia coli O127:H6 str. E2348/69 major tail protein YP_002328968.1 1459196 D 574521 CDS YP_002328969.1 215486538 7064217 1459927..1460301 1 NC_011601.1 minor tail protein 1460301 7064217 E2348C_1430 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328969.1 1459927 D 574521 CDS YP_002328970.1 215486539 7064218 1460325..1460606 1 NC_011601.1 minor tail protein 1460606 7064218 E2348C_1431 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328970.1 1460325 D 574521 CDS YP_002328971.1 215486540 7064219 1460654..1463896 1 NC_011601.1 tail length tape measure protein 1463896 7064219 E2348C_1432 Escherichia coli O127:H6 str. E2348/69 tail length tape measure protein YP_002328971.1 1460654 D 574521 CDS YP_002328972.1 215486541 7064220 1463889..1464230 1 NC_011601.1 minor tail protein 1464230 7064220 E2348C_1433 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328972.1 1463889 D 574521 CDS YP_002328973.1 215486542 7064221 1464230..1464928 1 NC_011601.1 minor tail protein 1464928 7064221 E2348C_1434 Escherichia coli O127:H6 str. E2348/69 minor tail protein YP_002328973.1 1464230 D 574521 CDS YP_002328974.1 215486543 7064222 1464934..1465677 1 NC_011601.1 tail assembly protein 1465677 7064222 E2348C_1435 Escherichia coli O127:H6 str. E2348/69 tail assembly protein YP_002328974.1 1464934 D 574521 CDS YP_002328975.1 215486544 7064223 1465575..1466255 1 NC_011601.1 tail assembly protein 1466255 7064223 E2348C_1436 Escherichia coli O127:H6 str. E2348/69 tail assembly protein YP_002328975.1 1465575 D 574521 CDS YP_002328976.1 215486545 7064224 1466496..1469969 1 NC_011601.1 host specificity protein 1469969 7064224 E2348C_1437 Escherichia coli O127:H6 str. E2348/69 host specificity protein YP_002328976.1 1466496 D 574521 CDS YP_002328977.1 215486546 7064225 1470037..1470636 1 NC_011601.1 outer membrane precursor Lom 1470636 7064225 E2348C_1438 Escherichia coli O127:H6 str. E2348/69 outer membrane precursor Lom YP_002328977.1 1470037 D 574521 CDS YP_002328978.1 215486547 7064226 1470788..1472065 1 NC_011601.1 side tail fiber protein 1472065 7064226 E2348C_1439 Escherichia coli O127:H6 str. E2348/69 side tail fiber protein YP_002328978.1 1470788 D 574521 CDS YP_002328979.1 215486548 7064227 1472067..1472336 1 NC_011601.1 hypothetical protein 1472336 7064227 E2348C_1440 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328979.1 1472067 D 574521 CDS YP_002328980.1 215486549 7064228 1472557..1473099 1 NC_011601.1 hypothetical protein 1473099 7064228 E2348C_1441 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328980.1 1472557 D 574521 CDS YP_002328981.1 215486550 7064445 complement(1473581..1474903) 1 NC_011601.1 T3SS secreted effector NleA/EspI-like protein 1474903 7064445 E2348C_1442 Escherichia coli O127:H6 str. E2348/69 T3SS secreted effector NleA/EspI-like protein YP_002328981.1 1473581 R 574521 CDS YP_002328982.1 215486551 7064448 1476724..1477635 1 NC_011601.1 T3SS secreted effector NleH-like protein 1477635 7064448 E2348C_1444 Escherichia coli O127:H6 str. E2348/69 T3SS secreted effector NleH-like protein YP_002328982.1 1476724 D 574521 CDS YP_002328983.1 215486552 7064449 1477701..1478270 1 NC_011601.1 T3SS secreted effector NleF-like protein 1478270 7064449 E2348C_1445 Escherichia coli O127:H6 str. E2348/69 T3SS secreted effector NleF-like protein YP_002328983.1 1477701 D 574521 CDS YP_002328984.1 215486553 7064990 complement(1480807..1481265) 1 NC_011601.1 transposase of IS200C 1481265 7064990 E2348C_1448 Escherichia coli O127:H6 str. E2348/69 transposase of IS200C YP_002328984.1 1480807 R 574521 CDS YP_002328985.1 215486554 7064991 1481557..1482930 1 NC_011601.1 transposase of ISEc13 1482930 7064991 E2348C_1449 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002328985.1 1481557 D 574521 CDS YP_002328986.1 215486555 7064451 complement(1483006..1483812) 1 NC_011601.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1483812 trpA 7064451 trpA Escherichia coli O127:H6 str. E2348/69 tryptophan synthase subunit alpha YP_002328986.1 1483006 R 574521 CDS YP_002328987.1 215486556 7062253 complement(1483812..1485005) 1 NC_011601.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1485005 trpB 7062253 trpB Escherichia coli O127:H6 str. E2348/69 tryptophan synthase subunit beta YP_002328987.1 1483812 R 574521 CDS YP_002328988.1 215486557 7062254 complement(1485017..1486375) 1 NC_011601.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1486375 trpC 7062254 trpC Escherichia coli O127:H6 str. E2348/69 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_002328988.1 1485017 R 574521 CDS YP_002328989.1 215486558 7062255 complement(1486379..1487974) 1 NC_011601.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 1487974 trpD 7062255 trpD Escherichia coli O127:H6 str. E2348/69 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase YP_002328989.1 1486379 R 574521 CDS YP_002328990.1 215486559 7062256 complement(1487974..1489530) 1 NC_011601.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1489530 trpE 7062256 trpE Escherichia coli O127:H6 str. E2348/69 anthranilate synthase component I YP_002328990.1 1487974 R 574521 CDS YP_002328992.1 215486561 7062259 1489804..1490685 1 NC_011601.1 hypothetical protein 1490685 trpH 7062259 trpH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328992.1 1489804 D 574521 CDS YP_002328993.1 215486562 7062258 1490682..1491302 1 NC_011601.1 hypothetical protein 1491302 yciO 7062258 yciO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328993.1 1490682 D 574521 CDS YP_002328994.1 215486563 7061495 1491330..1493219 1 NC_011601.1 hypothetical protein 1493219 yciQ 7061495 yciQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328994.1 1491330 D 574521 CDS YP_002328995.1 215486564 7061496 1493432..1494307 1 NC_011601.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1494307 rluB 7061496 rluB Escherichia coli O127:H6 str. E2348/69 23S rRNA pseudouridylate synthase B YP_002328995.1 1493432 D 574521 CDS YP_002328996.1 215486565 7060839 complement(1494347..1494937) 1 NC_011601.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 1494937 btuR 7060839 btuR Escherichia coli O127:H6 str. E2348/69 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_002328996.1 1494347 R 574521 CDS YP_002328997.1 215486566 7064312 complement(1494934..1495692) 1 NC_011601.1 short chain dehydrogenase 1495692 yciK 7064312 yciK Escherichia coli O127:H6 str. E2348/69 short chain dehydrogenase YP_002328997.1 1494934 R 574521 CDS YP_002328998.1 215486567 7061492 1495912..1496961 1 NC_011601.1 SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 1496961 sohB 7061492 sohB Escherichia coli O127:H6 str. E2348/69 periplasmic protease YP_002328998.1 1495912 D 574521 CDS YP_002328999.1 215486568 7062735 complement(1496997..1497248) 1 NC_011601.1 hypothetical protein 1497248 yciN 7062735 yciN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002328999.1 1496997 R 574521 CDS YP_002329000.1 215486569 7061494 1497628..1500225 1 NC_011601.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1500225 topA 7061494 topA Escherichia coli O127:H6 str. E2348/69 DNA topoisomerase I YP_002329000.1 1497628 D 574521 CDS YP_002329001.1 215486570 7061818 1500435..1501409 1 NC_011601.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1501409 cysB 7061818 cysB Escherichia coli O127:H6 str. E2348/69 transcriptional regulator CysB YP_002329001.1 1500435 D 574521 CDS YP_002329002.1 215486571 7065194 1501740..1501868 1 NC_011601.1 hypothetical protein 1501868 ymiA 7065194 ymiA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329002.1 1501740 D 574521 CDS YP_002329003.1 215486572 7062036 1501871..1502038 1 NC_011601.1 hypothetical protein 1502038 yciX 7062036 yciX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329003.1 1501871 D 574521 CDS YP_002329004.1 215486573 7062949 1502410..1505085 1 NC_011601.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1505085 acnA 7062949 acnA Escherichia coli O127:H6 str. E2348/69 aconitate hydratase YP_002329004.1 1502410 D 574521 CDS YP_002329005.1 215486574 7062390 complement(1505149..1505739) 1 NC_011601.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1505739 ribA 7062390 ribA Escherichia coli O127:H6 str. E2348/69 GTP cyclohydrolase II YP_002329005.1 1505149 R 574521 CDS YP_002329006.1 215486575 7060818 1505909..1506673 1 NC_011601.1 phosphatidylglycerophosphatase B 1506673 pgpB 7060818 pgpB Escherichia coli O127:H6 str. E2348/69 phosphatidylglycerophosphatase B YP_002329006.1 1505909 D 574521 CDS YP_002329007.1 215486576 7060718 1506822..1507130 1 NC_011601.1 hypothetical protein 1507130 yciS 7060718 yciS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329007.1 1506822 D 574521 CDS YP_002329008.1 215486577 7061497 1507137..1508306 1 NC_011601.1 tetratricopeptide repeat protein 1508306 yciM 7061497 yciM Escherichia coli O127:H6 str. E2348/69 tetratricopeptide repeat protein YP_002329008.1 1507137 D 574521 CDS YP_002329009.1 215486578 7061493 1508498..1509235 1 NC_011601.1 orotidine-5'-phosphate decarboxylase 1509235 pyrF 7061493 pyrF Escherichia coli O127:H6 str. E2348/69 orotidine-5'-phosphate decarboxylase YP_002329009.1 1508498 D 574521 CDS YP_002329010.1 215486579 7063933 1509235..1509561 1 NC_011601.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 1509561 yciH 7063933 yciH Escherichia coli O127:H6 str. E2348/69 translation initiation factor Sui1 YP_002329010.1 1509235 D 574521 CDS YP_002329011.1 215486580 7061490 complement(1509687..1509905) 1 NC_011601.1 lipoprotein 1509905 osmB 7061490 osmB Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002329011.1 1509687 R 574521 CDS YP_002329012.1 215486581 7062889 complement(1510174..1510923) 1 NC_011601.1 DNA-binding transcriptional regulator 1510923 yciT 7062889 yciT Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329012.1 1510174 R 574521 CDS YP_002329013.1 215486582 7061498 complement(1511013..1511186) 1 NC_011601.1 hypothetical protein 1511186 yciZ 7061498 yciZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329013.1 1511013 R 574521 CDS YP_002329014.1 215486583 7062951 complement(1511334..1513292) 1 NC_011601.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator 1513292 gmr 7062951 gmr Escherichia coli O127:H6 str. E2348/69 RNase II stability modulator YP_002329014.1 1511334 R 574521 CDS YP_002329015.1 215486584 7064992 complement(1513622..1514080) 1 NC_011601.1 transposase of IS200C 1514080 7064992 E2348C_1479 Escherichia coli O127:H6 str. E2348/69 transposase of IS200C YP_002329015.1 1513622 R 574521 CDS YP_002329016.1 215486585 7064452 complement(1514265..1516199) 1 NC_011601.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1516199 rnb 7064452 rnb Escherichia coli O127:H6 str. E2348/69 exoribonuclease II YP_002329016.1 1514265 R 574521 CDS YP_002329017.1 215486586 7060847 complement(1516239..1517393) 1 NC_011601.1 oxidoreductase 1517393 yciW 7060847 yciW Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002329017.1 1516239 R 574521 CDS YP_002329018.1 215486587 7062948 complement(1517538..1518326) 1 NC_011601.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 1518326 fabI 7062948 fabI Escherichia coli O127:H6 str. E2348/69 enoyl-ACP reductase YP_002329018.1 1517538 R 574521 CDS YP_002329019.1 215486588 7062068 1518804..1519370 1 NC_011601.1 transcription regulatory protein 1519370 7062068 E2348C_1483 Escherichia coli O127:H6 str. E2348/69 transcription regulatory protein YP_002329019.1 1518804 D 574521 CDS YP_002329020.1 215486589 7064453 1519519..1520640 1 NC_011601.1 multidrug-efflux transport protein 1520640 7064453 E2348C_1484 Escherichia coli O127:H6 str. E2348/69 multidrug-efflux transport protein YP_002329020.1 1519519 D 574521 CDS YP_002329021.1 215486590 7064454 1520640..1523747 1 NC_011601.1 multidrug-efflux transport protein 1523747 7064454 E2348C_1485 Escherichia coli O127:H6 str. E2348/69 multidrug-efflux transport protein YP_002329021.1 1520640 D 574521 CDS YP_002329022.1 215486591 7064455 1523751..1525124 1 NC_011601.1 outer membrane channel protein 1525124 7064455 E2348C_1486 Escherichia coli O127:H6 str. E2348/69 outer membrane channel protein YP_002329022.1 1523751 D 574521 CDS YP_002329023.1 215486592 7064456 1525133..1526296 1 NC_011601.1 membrane transport protein 1526296 7064456 E2348C_1487 Escherichia coli O127:H6 str. E2348/69 membrane transport protein YP_002329023.1 1525133 D 574521 CDS YP_002329024.1 215486593 7064993 complement(1526326..1527699) 1 NC_011601.1 transposase of ISEc13 1527699 7064993 E2348C_1488 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002329024.1 1526326 R 574521 CDS YP_002329025.1 215486594 7064457 complement(1527902..1528708) 1 NC_011601.1 ATP-binding protein SapF of peptide transport system 1528708 sapF 7064457 sapF Escherichia coli O127:H6 str. E2348/69 ATP-binding protein SapF of peptide transport system YP_002329025.1 1527902 R 574521 CDS YP_002329026.1 215486595 7065331 complement(1528710..1529702) 1 NC_011601.1 ATP-binding protein SapD of peptide transport system 1529702 sapD 7065331 sapD Escherichia coli O127:H6 str. E2348/69 ATP-binding protein SapD of peptide transport system YP_002329026.1 1528710 R 574521 CDS YP_002329027.1 215486596 7065330 complement(1529702..1530592) 1 NC_011601.1 peptide transport permease SapC; membrane component of ABC superfamily 1530592 sapC 7065330 sapC Escherichia coli O127:H6 str. E2348/69 peptide transport permease SapC; membrane component of ABC superfamily YP_002329027.1 1529702 R 574521 CDS YP_002329028.1 215486597 7065329 complement(1530579..1531544) 1 NC_011601.1 peptide transport permease SapB; membrane component of ABC superfamily 1531544 sapB 7065329 sapB Escherichia coli O127:H6 str. E2348/69 peptide transport permease SapB; membrane component of ABC superfamily YP_002329028.1 1530579 R 574521 CDS YP_002329029.1 215486598 7065328 complement(1531541..1533184) 1 NC_011601.1 peptide transport periplasmic protein SapA; periplasmic-binding component of ABC superfamily 1533184 sapA 7065328 sapA Escherichia coli O127:H6 str. E2348/69 peptide transport periplasmic protein SapA; periplasmic-binding component of ABC superfamily YP_002329029.1 1531541 R 574521 CDS YP_002329030.1 215486599 7065327 complement(1533497..1533742) 1 NC_011601.1 hypothetical protein 1533742 ymjA 7065327 ymjA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329030.1 1533497 R 574521 CDS YP_002329031.1 215486600 7062037 complement(1534167..1535144) 1 NC_011601.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 1535144 pspF 7062037 pspF Escherichia coli O127:H6 str. E2348/69 phage shock protein operon transcriptional activator YP_002329031.1 1534167 R 574521 CDS YP_002329032.1 215486601 7061323 1535311..1535979 1 NC_011601.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1535979 pspA 7061323 pspA Escherichia coli O127:H6 str. E2348/69 phage shock protein PspA YP_002329032.1 1535311 D 574521 CDS YP_002329033.1 215486602 7061318 1536033..1536257 1 NC_011601.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1536257 pspB 7061318 pspB Escherichia coli O127:H6 str. E2348/69 phage shock protein B YP_002329033.1 1536033 D 574521 CDS YP_002329034.1 215486603 7061319 1536257..1536616 1 NC_011601.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1536616 pspC 7061319 pspC Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator PspC YP_002329034.1 1536257 D 574521 CDS YP_002329035.1 215486604 7061320 1536625..1536846 1 NC_011601.1 peripheral inner membrane phage-shock protein 1536846 pspD 7061320 pspD Escherichia coli O127:H6 str. E2348/69 peripheral inner membrane phage-shock protein YP_002329035.1 1536625 D 574521 CDS YP_002329036.1 215486605 7061321 1536921..1537235 1 NC_011601.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1537235 pspE 7061321 pspE Escherichia coli O127:H6 str. E2348/69 thiosulfate:cyanide sulfurtransferase YP_002329036.1 1536921 D 574521 CDS YP_002329037.1 215486606 7061322 1537449..1539128 1 NC_011601.1 glucosyltransferase 1539128 ycjM 7061322 ycjM Escherichia coli O127:H6 str. E2348/69 glucosyltransferase YP_002329037.1 1537449 D 574521 CDS YP_002329038.1 215486607 7062954 1539142..1540434 1 NC_011601.1 sugar transporter subunit: periplasmic-binding component of ABC superfamily 1540434 ycjN 7062954 ycjN Escherichia coli O127:H6 str. E2348/69 sugar transporter subunit: periplasmic-binding component of ABC superfamily YP_002329038.1 1539142 D 574521 CDS YP_002329039.1 215486608 7062955 1540455..1541336 1 NC_011601.1 sugar transporter subunit: membrane component of ABC superfamily 1541336 ycjO 7062955 ycjO Escherichia coli O127:H6 str. E2348/69 sugar transporter subunit: membrane component of ABC superfamily YP_002329039.1 1540455 D 574521 CDS YP_002329040.1 215486609 7062956 1541323..1542165 1 NC_011601.1 sugar transporter subunit: membrane component of ABC superfamily 1542165 ycjP 7062956 ycjP Escherichia coli O127:H6 str. E2348/69 sugar transporter subunit: membrane component of ABC superfamily YP_002329040.1 1541323 D 574521 CDS YP_002329041.1 215486610 7062957 1542196..1543248 1 NC_011601.1 oxidoreductase, Zn-dependent and NAD(P)-binding 1543248 ycjQ 7062957 ycjQ Escherichia coli O127:H6 str. E2348/69 oxidoreductase, Zn-dependent and NAD(P)-binding YP_002329041.1 1542196 D 574521 CDS YP_002329042.1 215486611 7062958 1543267..1544055 1 NC_011601.1 hypothetical protein 1544055 ycjR 7062958 ycjR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329042.1 1543267 D 574521 CDS YP_002329043.1 215486612 7062959 1544065..1545120 1 NC_011601.1 oxidoreductase, NADH-binding 1545120 ycjS 7062959 ycjS Escherichia coli O127:H6 str. E2348/69 oxidoreductase, NADH-binding YP_002329043.1 1544065 D 574521 CDS YP_002329044.1 215486613 7064994 1547370..1548743 1 NC_011601.1 transposase of ISEc13 1548743 7064994 E2348C_1509 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002329044.1 1547370 D 574521 CDS YP_002329045.1 215486614 7064458 1548940..1549599 1 NC_011601.1 beta-phosphoglucomutase 1549599 ycjU 7064458 ycjU Escherichia coli O127:H6 str. E2348/69 beta-phosphoglucomutase YP_002329045.1 1548940 D 574521 CDS YP_002329046.1 215486615 7062961 1549613..1550695 1 NC_011601.1 sugar transporter subunit: ATP-binding component of ABC superfamily 1550695 ycjV 7062961 ycjV Escherichia coli O127:H6 str. E2348/69 sugar transporter subunit: ATP-binding component of ABC superfamily YP_002329046.1 1549613 D 574521 CDS YP_002329047.1 215486616 7062962 1550740..1551645 1 NC_011601.1 outer membrane porin OmpG 1551645 ompG 7062962 ompG Escherichia coli O127:H6 str. E2348/69 outer membrane porin OmpG YP_002329047.1 1550740 D 574521 CDS YP_002329048.1 215486617 7062876 complement(1551696..1552694) 1 NC_011601.1 DNA-binding transcriptional regulator 1552694 ycjW 7062876 ycjW Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329048.1 1551696 R 574521 CDS YP_002329049.1 215486618 7062963 1552851..1554248 1 NC_011601.1 hypothetical protein 1554248 ycjX 7062963 ycjX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329049.1 1552851 D 574521 CDS YP_002329050.1 215486619 7062964 1554245..1555306 1 NC_011601.1 hypothetical protein 1555306 ycjF 7062964 ycjF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329050.1 1554245 D 574521 CDS YP_002329051.1 215486620 7062952 1555454..1556995 1 NC_011601.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1556995 tyrR 7062952 tyrR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator TyrR YP_002329051.1 1555454 D 574521 CDS YP_002329052.1 215486621 7062286 complement(1557039..1557545) 1 NC_011601.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1557545 tpx 7062286 tpx Escherichia coli O127:H6 str. E2348/69 thiol peroxidase YP_002329052.1 1557039 R 574521 CDS YP_002329053.1 215486622 7062231 1557664..1558629 1 NC_011601.1 L-Ala-D/L-Glu epimerase 1558629 ycjG 7062231 ycjG Escherichia coli O127:H6 str. E2348/69 L-Ala-D/L-Glu epimerase YP_002329053.1 1557664 D 574521 CDS YP_002329054.1 215486623 7062953 complement(1558604..1559332) 1 NC_011601.1 murein peptide amidase A 1559332 mpaA 7062953 mpaA Escherichia coli O127:H6 str. E2348/69 murein peptide amidase A YP_002329054.1 1558604 R 574521 CDS YP_002329055.1 215486624 7063823 complement(1559623..1560261) 1 NC_011601.1 NAD-dependent epimerase/dehydratase 1560261 ymjC 7063823 ymjC Escherichia coli O127:H6 str. E2348/69 NAD-dependent epimerase/dehydratase YP_002329055.1 1559623 R 574521 CDS YP_002329056.1 215486625 7062038 complement(1560332..1561249) 1 NC_011601.1 hydrolase 1561249 ycjY 7062038 ycjY Escherichia coli O127:H6 str. E2348/69 hydrolase YP_002329056.1 1560332 R 574521 CDS YP_002329057.1 215486626 7062965 1561390..1562289 1 NC_011601.1 DNA-binding transcriptional regulator 1562289 ycjZ 7062965 ycjZ Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329057.1 1561390 D 574521 CDS YP_002329058.1 215486627 7062966 1562626..1564239 1 NC_011601.1 murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit 1564239 mppA 7062966 mppA Escherichia coli O127:H6 str. E2348/69 murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit YP_002329058.1 1562626 D 574521 CDS YP_002329059.1 215486628 7063826 complement(1564290..1565321) 1 NC_011601.1 hypothetical protein 1565321 ynaI 7063826 ynaI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329059.1 1564290 R 574521 CDS YP_002329060.1 215486629 7062039 1565565..1565822 1 NC_011601.1 hypothetical protein 1565822 ynaJ 7062039 ynaJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329060.1 1565565 D 574521 CDS YP_002329061.1 215486630 7062040 complement(1565872..1566822) 1 NC_011601.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1566822 uspE 7062040 uspE Escherichia coli O127:H6 str. E2348/69 universal stress protein UspE YP_002329061.1 1565872 R 574521 CDS YP_002329062.1 215486631 7062336 complement(1566974..1567726) 1 NC_011601.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1567726 fnr 7062336 fnr Escherichia coli O127:H6 str. E2348/69 fumarate/nitrate reduction transcriptional regulator YP_002329062.1 1566974 R 574521 CDS YP_002329063.1 215486632 7061936 complement(1567921..1568436) 1 NC_011601.1 O-6-alkylguanine-DNA:cysteine-protein methyltransferase 1568436 ogt 7061936 ogt Escherichia coli O127:H6 str. E2348/69 O-6-alkylguanine-DNA:cysteine-protein methyltransferase YP_002329063.1 1567921 R 574521 CDS YP_002329064.1 215486633 7063559 complement(1568968..1569783) 1 NC_011601.1 hypothetical protein 1569783 7063559 E2348C_1529 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329064.1 1568968 R 574521 CDS YP_002329065.1 215486634 7064459 1569877..1570908 1 NC_011601.1 multidrug resistance efflux pump, HlyD family 1570908 7064459 E2348C_1530 Escherichia coli O127:H6 str. E2348/69 multidrug resistance efflux pump, HlyD family YP_002329065.1 1569877 D 574521 CDS YP_002329066.1 215486635 7064461 1572613..1573176 1 NC_011601.1 hypothetical protein 1573176 ydaL 7064461 ydaL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329066.1 1572613 D 574521 CDS YP_002329067.1 215486636 7062968 1574596..1575579 1 NC_011601.1 zinc transporter 1575579 zntB 7062968 zntB Escherichia coli O127:H6 str. E2348/69 zinc transporter YP_002329067.1 1574596 D 574521 CDS YP_002329068.1 215486637 7061145 1576057..1577430 1 NC_011601.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1577430 dbpA 7061145 dbpA Escherichia coli O127:H6 str. E2348/69 ATP-dependent RNA helicase DbpA YP_002329068.1 1576057 D 574521 CDS YP_002329069.1 215486638 7065225 complement(1577559..1578494) 1 NC_011601.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1578494 ttcA 7065225 ttcA Escherichia coli O127:H6 str. E2348/69 C32 tRNA thiolase YP_002329069.1 1577559 R 574521 CDS YP_002329070.1 215486639 7061142 complement(1580818..1581252) 1 NC_011601.1 stress-induced protein, ATP-binding protein 1581252 uspF 7061142 uspF Escherichia coli O127:H6 str. E2348/69 stress-induced protein, ATP-binding protein YP_002329070.1 1580818 R 574521 CDS YP_002329071.1 215486640 7062337 complement(1581393..1582526) 1 NC_011601.1 outer membrane pore protein N, non-specific 1582526 ompN 7062337 ompN Escherichia coli O127:H6 str. E2348/69 outer membrane pore protein N, non-specific YP_002329071.1 1581393 R 574521 CDS YP_002329072.1 215486641 7063786 complement(1582891..1586415) 1 NC_011601.1 fused pyruvate-flavodoxin oxidoreductase: conserved protein/conserved protein/FeS binding protein 1586415 ydbK 7063786 ydbK Escherichia coli O127:H6 str. E2348/69 fused pyruvate-flavodoxin oxidoreductase: conserved protein/conserved protein/FeS binding protein YP_002329072.1 1582891 R 574521 CDS YP_002329073.1 215486642 7062972 1586689..1586955 1 NC_011601.1 hypothetical protein 1586955 ydbJ 7062972 ydbJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329073.1 1586689 D 574521 CDS YP_002329074.1 215486643 7062971 complement(1586952..1587374) 1 NC_011601.1 heat-inducible protein 1587374 hslJ 7062971 hslJ Escherichia coli O127:H6 str. E2348/69 heat-inducible protein YP_002329074.1 1586952 R 574521 CDS YP_002329075.1 215486644 7062182 complement(1587485..1588474) 1 NC_011601.1 fermentative D-lactate dehydrogenase, NAD-dependent 1588474 ldhA 7062182 ldhA Escherichia coli O127:H6 str. E2348/69 fermentative D-lactate dehydrogenase, NAD-dependent YP_002329075.1 1587485 R 574521 CDS YP_002329076.1 215486645 7061514 1588682..1591321 1 NC_011601.1 hypothetical protein 1591321 ydbH 7061514 ydbH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329076.1 1588682 D 574521 CDS YP_002329077.1 215486646 7062970 1591318..1591503 1 NC_011601.1 lipoprotein 1591503 ynbE 7062970 ynbE Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002329077.1 1591318 D 574521 CDS YP_002329078.1 215486647 7062041 1591511..1591837 1 NC_011601.1 hypothetical protein 1591837 ydbL 7062041 ydbL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329078.1 1591511 D 574521 CDS YP_002329079.1 215486648 7062899 1593171..1594037 1 NC_011601.1 oxidoreductase 1594037 ydbC 7062899 ydbC Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002329079.1 1593171 D 574521 CDS YP_002329080.1 215486649 7064995 complement(1594073..1595446) 1 NC_011601.1 transposase of ISEc13 1595446 7064995 E2348C_1549 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002329080.1 1594073 R 574521 CDS YP_002329081.1 215486650 7064462 complement(1595638..1596243) 1 NC_011601.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1596243 azoR 7064462 azoR Escherichia coli O127:H6 str. E2348/69 azoreductase YP_002329081.1 1595638 R 574521 CDS YP_002329082.1 215486651 7062489 1596501..1600346 1 NC_011601.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1600346 hrpA 7062489 hrpA Escherichia coli O127:H6 str. E2348/69 ATP-dependent RNA helicase HrpA YP_002329082.1 1596501 D 574521 CDS YP_002329083.1 215486652 7062178 1600620..1601420 1 NC_011601.1 hypothetical protein 1601420 ydcF 7062178 ydcF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329083.1 1600620 D 574521 CDS YP_002329084.1 215486653 7062974 1601617..1603056 1 NC_011601.1 NAD-linked; aldehyde dehydrogenase 1603056 aldA 7062974 aldA Escherichia coli O127:H6 str. E2348/69 aldehyde dehydrogenase YP_002329084.1 1601617 D 574521 CDS YP_002329085.1 215486654 7062435 complement(1603098..1604099) 1 NC_011601.1 glyceraldehyde-3-phosphate dehydrogenase 1604099 gapC 7062435 gapC Escherichia coli O127:H6 str. E2348/69 glyceraldehyde-3-phosphate dehydrogenase YP_002329085.1 1603098 R 574521 CDS YP_002329086.1 215486655 7061626 1604288..1604818 1 NC_011601.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1604818 cybB 7061626 cybB Escherichia coli O127:H6 str. E2348/69 cytochrome b561 YP_002329086.1 1604288 D 574521 CDS YP_002329087.1 215486656 7064594 1605063..1605236 1 NC_011601.1 hypothetical protein 1605236 ydcA 7064594 ydcA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329087.1 1605063 D 574521 CDS YP_002329088.1 215486657 7064997 complement(1605864..1606940) 1 NC_011601.1 transposase of ISEc21 1606940 7064997 E2348C_1558 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc21 YP_002329088.1 1605864 R 574521 CDS YP_002329089.1 215486658 7064463 complement(1607778..1608080) 1 NC_011601.1 transposase Orf1 of IS911 1608080 7064463 E2348C_1560 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS911 YP_002329089.1 1607778 R 574521 CDS YP_002329090.1 215486659 7065000 complement(1608734..1610107) 1 NC_011601.1 transposase of ISEc13 1610107 7065000 E2348C_1562 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002329090.1 1608734 R 574521 CDS YP_002329091.1 215486660 7064464 complement(1610574..1611095) 1 NC_011601.1 transposase Orf1 of IS150 1611095 7064464 E2348C_1564 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS150 YP_002329091.1 1610574 R 574521 CDS YP_002329092.1 215486661 7062238 complement(1611816..1612739) 1 NC_011601.1 DNA-binding transcriptional regulator 1612739 ydcI 7062238 ydcI Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329092.1 1611816 R 574521 CDS YP_002329093.1 215486662 7062976 1612956..1614299 1 NC_011601.1 hypothetical protein 1614299 ydcJ 7062976 ydcJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329093.1 1612956 D 574521 CDS YP_002329094.1 215486663 7062977 1614524..1616179 1 NC_011601.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1616179 mdoD 7062977 mdoD Escherichia coli O127:H6 str. E2348/69 glucan biosynthesis protein D YP_002329094.1 1614524 D 574521 CDS YP_002329095.1 215486664 7065303 1616319..1616543 1 NC_011601.1 hypothetical protein 1616543 ydcH 7065303 ydcH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329095.1 1616319 D 574521 CDS YP_002329096.1 215486665 7062975 1616606..1617145 1 NC_011601.1 ribosomal-protein-L7/L12-serine acetyltransferase 1617145 rimL 7062975 rimL Escherichia coli O127:H6 str. E2348/69 ribosomal-protein-L7/L12-serine acetyltransferase YP_002329096.1 1616606 D 574521 CDS YP_002329097.1 215486666 7060830 complement(1617137..1618117) 1 NC_011601.1 hypothetical protein 1618117 ydcK 7060830 ydcK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329097.1 1617137 R 574521 CDS YP_002329098.1 215486667 7062978 1618241..1619233 1 NC_011601.1 potassium-tellurite ethidium and proflavin transporter 1619233 tehA 7062978 tehA Escherichia coli O127:H6 str. E2348/69 potassium-tellurite ethidium and proflavin transporter YP_002329098.1 1618241 D 574521 CDS YP_002329099.1 215486668 7061774 1619230..1619823 1 NC_011601.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1619823 tehB 7061774 tehB Escherichia coli O127:H6 str. E2348/69 tellurite resistance protein TehB YP_002329099.1 1619230 D 574521 CDS YP_002329100.1 215486669 7061775 1620126..1620794 1 NC_011601.1 lipoprotein 1620794 ydcL 7061775 ydcL Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002329100.1 1620126 D 574521 CDS YP_002329101.1 215486670 7062979 complement(1620829..1622001) 1 NC_011601.1 benzoate transporter 1622001 ydcO 7062979 ydcO Escherichia coli O127:H6 str. E2348/69 benzoate transporter YP_002329101.1 1620829 R 574521 CDS YP_002329102.1 215486671 7062981 1622093..1622629 1 NC_011601.1 DNA-binding transcriptional regulator 1622629 ydcN 7062981 ydcN Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329102.1 1622093 D 574521 CDS YP_002329103.1 215486672 7062980 1622702..1624663 1 NC_011601.1 peptidase 1624663 ydcP 7062980 ydcP Escherichia coli O127:H6 str. E2348/69 peptidase YP_002329103.1 1622702 D 574521 CDS YP_002329104.1 215486673 7062982 complement(1624755..1624985) 1 NC_011601.1 hypothetical protein 1624985 yncJ 7062982 yncJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329104.1 1624755 R 574521 CDS YP_002329105.1 215486674 7062045 1625335..1626741 1 NC_011601.1 fused DNA-binding transcriptional regulator/ amino transferase 1626741 ydcR 7062045 ydcR Escherichia coli O127:H6 str. E2348/69 fused DNA-binding transcriptional regulator/ amino transferase YP_002329105.1 1625335 D 574521 CDS YP_002329106.1 215486675 7062983 1626986..1628131 1 NC_011601.1 spermidine/putrescine transporter subunit 1628131 ydcS 7062983 ydcS Escherichia coli O127:H6 str. E2348/69 spermidine/putrescine transporter subunit YP_002329106.1 1626986 D 574521 CDS YP_002329107.1 215486676 7062984 1628149..1629162 1 NC_011601.1 spermidine/putrescine transporter subunit, membrane component of ABC superfamily 1629162 ydcT 7062984 ydcT Escherichia coli O127:H6 str. E2348/69 spermidine/putrescine transporter subunit, membrane component of ABC superfamily YP_002329107.1 1628149 D 574521 CDS YP_002329108.1 215486677 7062985 1629163..1630104 1 NC_011601.1 spermidine/putrescine transporter subunit 1630104 ydcU 7062985 ydcU Escherichia coli O127:H6 str. E2348/69 spermidine/putrescine transporter subunit YP_002329108.1 1629163 D 574521 CDS YP_002329109.1 215486678 7062986 1630094..1630888 1 NC_011601.1 spermidine/putrescine transporter subunit, membrane component of ABC superfamily 1630888 ydcV 7062986 ydcV Escherichia coli O127:H6 str. E2348/69 spermidine/putrescine transporter subunit, membrane component of ABC superfamily YP_002329109.1 1630094 D 574521 CDS YP_002329110.1 215486679 7062987 1630910..1632334 1 NC_011601.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1632334 ydcW 7062987 ydcW Escherichia coli O127:H6 str. E2348/69 gamma-aminobutyraldehyde dehydrogenase YP_002329110.1 1630910 D 574521 CDS YP_002329111.1 215486680 7062988 complement(1632431..1632526) 1 NC_011601.1 hypothetical protein 1632526 yncL 7062988 yncL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329111.1 1632431 R 574521 CDS YP_002329112.1 215486681 7062046 1632721..1632894 1 NC_011601.1 hypothetical protein 1632894 ydcX 7062046 ydcX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329112.1 1632721 D 574521 CDS YP_002329113.1 215486682 7062989 1632980..1633213 1 NC_011601.1 hypothetical protein 1633213 ydcY 7062989 ydcY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329113.1 1632980 D 574521 CDS YP_002329114.1 215486683 7062990 complement(1633214..1633663) 1 NC_011601.1 hypothetical protein 1633663 ydcZ 7062990 ydcZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329114.1 1633214 R 574521 CDS YP_002329115.1 215486684 7062991 complement(1633660..1634178) 1 NC_011601.1 acyltransferase 1634178 yncA 7062991 yncA Escherichia coli O127:H6 str. E2348/69 acyltransferase YP_002329115.1 1633660 R 574521 CDS YP_002329116.1 215486685 7064466 complement(1634659..1636761) 1 NC_011601.1 iron outer membrane transporter 1636761 yncD 7064466 yncD Escherichia coli O127:H6 str. E2348/69 iron outer membrane transporter YP_002329116.1 1634659 R 574521 CDS YP_002329117.1 215486686 7062043 1637003..1638064 1 NC_011601.1 hypothetical protein 1638064 yncE 7062043 yncE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329117.1 1637003 D 574521 CDS YP_002329118.1 215486687 7062044 complement(1638177..1639676) 1 NC_011601.1 L-asparagine transporter 1639676 ansP 7062044 ansP Escherichia coli O127:H6 str. E2348/69 L-asparagine transporter YP_002329118.1 1638177 R 574521 CDS YP_002329119.1 215486688 7061346 1640463..1640993 1 NC_011601.1 hypothetical protein 1640993 7061346 E2348C_1594 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329119.1 1640463 D 574521 CDS YP_002329120.1 215486689 7064467 1641007..1641345 1 NC_011601.1 hypothetical protein 1641345 7064467 E2348C_1595 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329120.1 1641007 D 574521 CDS YP_002329121.1 215486690 7064470 1644960..1645187 1 NC_011601.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 1645187 pptA 7064470 pptA Escherichia coli O127:H6 str. E2348/69 4-oxalocrotonate tautomerase YP_002329121.1 1644960 D 574521 CDS YP_002329122.1 215486691 7061277 complement(1645193..1645762) 1 NC_011601.1 hypothetical protein 1645762 yddH 7061277 yddH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329122.1 1645193 R 574521 CDS YP_002329123.1 215486692 7062996 1645937..1646782 1 NC_011601.1 N-hydroxyarylamine O-acetyltransferase 1646782 nhoA 7062996 nhoA Escherichia coli O127:H6 str. E2348/69 N-hydroxyarylamine O-acetyltransferase YP_002329123.1 1645937 D 574521 CDS YP_002329124.1 215486693 7065390 complement(1646878..1647771) 1 NC_011601.1 hypothetical protein 1647771 yddE 7065390 yddE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329124.1 1646878 R 574521 CDS YP_002329125.1 215486694 7062994 complement(1647851..1648531) 1 NC_011601.1 nitrate reductase 2 (NRZ), gamma subunit 1648531 narV 7062994 narV Escherichia coli O127:H6 str. E2348/69 nitrate reductase 2 (NRZ), gamma subunit YP_002329125.1 1647851 R 574521 CDS YP_002329126.1 215486695 7065371 complement(1648528..1649223) 1 NC_011601.1 nitrate reductase 2 (NRZ), delta subunit (assembly subunit) 1649223 narW 7065371 narW Escherichia coli O127:H6 str. E2348/69 nitrate reductase 2 (NRZ), delta subunit (assembly subunit) YP_002329126.1 1648528 R 574521 CDS YP_002329127.1 215486696 7065372 complement(1649223..1650767) 1 NC_011601.1 nitrate reductase 2 (NRZ), beta subunit 1650767 narY 7065372 narY Escherichia coli O127:H6 str. E2348/69 nitrate reductase 2 (NRZ), beta subunit YP_002329127.1 1649223 R 574521 CDS YP_002329128.1 215486697 7065374 complement(1650764..1654504) 1 NC_011601.1 nitrate reductase 2 (NRZ), alpha subunit 1654504 narZ 7065374 narZ Escherichia coli O127:H6 str. E2348/69 nitrate reductase 2 (NRZ), alpha subunit YP_002329128.1 1650764 R 574521 CDS YP_002329129.1 215486698 7065375 complement(1654599..1655987) 1 NC_011601.1 nitrate/nitrite transporter 1655987 narU 7065375 narU Escherichia coli O127:H6 str. E2348/69 nitrate/nitrite transporter YP_002329129.1 1654599 R 574521 CDS YP_002329130.1 215486699 7060939 complement(1656266..1657090) 1 NC_011601.1 hypothetical protein 1657090 yddG 7060939 yddG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329130.1 1656266 R 574521 CDS YP_002329131.1 215486700 7062995 1657379..1660426 1 NC_011601.1 selenocysteine (Sec=>U); formate dehydrogenase-N alpha subunit 1660426 fdnG 7062995 fdnG Escherichia coli O127:H6 str. E2348/69 formate dehydrogenase-N alpha subunit YP_002329131.1 1657379 D 574521 CDS YP_002329132.1 215486701 7062088 1660439..1661323 1 NC_011601.1 formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible 1661323 fdnH 7062088 fdnH Escherichia coli O127:H6 str. E2348/69 formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible YP_002329132.1 1660439 D 574521 CDS YP_002329133.1 215486702 7062089 1661316..1661969 1 NC_011601.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1661969 fdnI 7062089 fdnI Escherichia coli O127:H6 str. E2348/69 formate dehydrogenase-N subunit gamma YP_002329133.1 1661316 D 574521 CDS YP_002329134.1 215486703 7062090 complement(1662020..1662304) 1 NC_011601.1 DNA-binding transcriptional regulator 1662304 yddM 7062090 yddM Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329134.1 1662020 R 574521 CDS YP_002329135.1 215486704 7062997 complement(1662768..1663778) 1 NC_011601.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 1663778 adhP 7062997 adhP Escherichia coli O127:H6 str. E2348/69 alcohol dehydrogenase YP_002329135.1 1662768 R 574521 CDS YP_002329136.1 215486705 7062407 complement(1663912..1665609) 1 NC_011601.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1665609 maeA 7062407 maeA Escherichia coli O127:H6 str. E2348/69 malate dehydrogenase YP_002329136.1 1663912 R 574521 CDS YP_002329137.1 215486706 7065267 complement(1665765..1665902) 1 NC_011601.1 protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase; 30S ribosomal subunit S22 1665902 rpsV 7065267 rpsV Escherichia coli O127:H6 str. E2348/69 30S ribosomal subunit S22 YP_002329137.1 1665765 R 574521 CDS YP_002329138.1 215486707 7062753 complement(1666004..1666219) 1 NC_011601.1 biofilm-dependent modulation protein 1666219 bdm 7062753 bdm Escherichia coli O127:H6 str. E2348/69 biofilm-dependent modulation protein YP_002329138.1 1666004 R 574521 CDS YP_002329139.1 215486708 7062505 1666564..1666995 1 NC_011601.1 osmotically inducible, stress-inducible membrane protein 1666995 osmC 7062505 osmC Escherichia coli O127:H6 str. E2348/69 osmotically inducible, stress-inducible membrane protein YP_002329139.1 1666564 D 574521 CDS YP_002329140.1 215486709 7062890 complement(1667184..1669583) 1 NC_011601.1 heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase 1669583 dos 7062890 dos Escherichia coli O127:H6 str. E2348/69 cAMP phosphodiesterase YP_002329140.1 1667184 R 574521 CDS YP_002329141.1 215486710 7065055 complement(1670150..1671469) 1 NC_011601.1 liprotein 1671469 yddW 7065055 yddW Escherichia coli O127:H6 str. E2348/69 liprotein YP_002329141.1 1670150 R 574521 CDS YP_002329142.1 215486711 7062998 complement(1671600..1673135) 1 NC_011601.1 glutamate: gamma-aminobutyric acid antiporter 1673135 gadC 7062998 gadC Escherichia coli O127:H6 str. E2348/69 glutamate: gamma-aminobutyric acid antiporter YP_002329142.1 1671600 R 574521 CDS YP_002329143.1 215486712 7061611 complement(1673291..1674691) 1 NC_011601.1 glutamate decarboxylase 1674691 gadB 7061611 gadB Escherichia coli O127:H6 str. E2348/69 glutamate decarboxylase YP_002329143.1 1673291 R 574521 CDS YP_002329144.1 215486713 7061610 complement(1675053..1677836) 1 NC_011601.1 peptidase 1677836 pqqL 7061610 pqqL Escherichia coli O127:H6 str. E2348/69 peptidase YP_002329144.1 1675053 R 574521 CDS YP_002329145.1 215486714 7061282 complement(1677893..1680265) 1 NC_011601.1 porin 1680265 yddB 7061282 yddB Escherichia coli O127:H6 str. E2348/69 porin YP_002329145.1 1677893 R 574521 CDS YP_002329146.1 215486715 7062993 complement(1680303..1681988) 1 NC_011601.1 fused multidrug transporter subunits of ABC superfamily: membrane component/ATP-binding component 1681988 yddA 7062993 yddA Escherichia coli O127:H6 str. E2348/69 fused multidrug transporter subunits of ABC superfamily: membrane component/ATP-binding component YP_002329146.1 1680303 R 574521 CDS YP_002329147.1 215486716 7062992 complement(1682279..1683436) 1 NC_011601.1 hypothetical protein 1683436 ydeM 7062992 ydeM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329147.1 1682279 R 574521 CDS YP_002329148.1 215486717 7063003 complement(1683488..1685170) 1 NC_011601.1 hypothetical protein 1685170 ydeN 7063003 ydeN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329148.1 1683488 R 574521 CDS YP_002329149.1 215486718 7063004 complement(1685572..1686333) 1 NC_011601.1 regulates the cellular response to acid resistance; transcriptional regulator YdeO 1686333 ydeO 7063004 ydeO Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YdeO YP_002329149.1 1685572 R 574521 CDS YP_002329150.1 215486719 7063005 complement(1686408..1686605) 1 NC_011601.1 hypothetical protein 1686605 7063005 E2348C_1627 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329150.1 1686408 R 574521 CDS YP_002329151.1 215486720 7064471 complement(1686853..1689132) 1 NC_011601.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase; oxidoreductase 1689132 ydeP 7064471 ydeP Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002329151.1 1686853 R 574521 CDS YP_002329152.1 215486721 7063006 complement(1689471..1690385) 1 NC_011601.1 fimbrial protein-like protein 1690385 ydeQ 7063006 ydeQ Escherichia coli O127:H6 str. E2348/69 fimbrial protein-like protein YP_002329152.1 1689471 R 574521 CDS YP_002329153.1 215486722 7063007 complement(1690444..1690947) 1 NC_011601.1 fimbrial protein-like protein 1690947 ydeR 7063007 ydeR Escherichia coli O127:H6 str. E2348/69 fimbrial protein-like protein YP_002329153.1 1690444 R 574521 CDS YP_002329154.1 215486723 7063008 complement(1690960..1691490) 1 NC_011601.1 fimbrial protein-like protein 1691490 ydeS 7063008 ydeS Escherichia coli O127:H6 str. E2348/69 fimbrial protein-like protein YP_002329154.1 1690960 R 574521 CDS YP_002329155.1 215486724 7063009 complement(1691504..1694155) 1 NC_011601.1 outer membrane usher protein 1694155 7063009 E2348C_1632 Escherichia coli O127:H6 str. E2348/69 outer membrane usher protein YP_002329155.1 1691504 R 574521 CDS YP_002329156.1 215486725 7064472 complement(1694197..1694907) 1 NC_011601.1 fimbrial chaperone protein 1694907 7064472 E2348C_1633 Escherichia coli O127:H6 str. E2348/69 fimbrial chaperone protein YP_002329156.1 1694197 R 574521 CDS YP_002329157.1 215486726 7064473 complement(1695269..1695832) 1 NC_011601.1 type 1 fimbrial protein 1695832 7064473 E2348C_1634 Escherichia coli O127:H6 str. E2348/69 type 1 fimbrial protein YP_002329157.1 1695269 R 574521 CDS YP_002329158.1 215486727 7064474 1697259..1698359 1 NC_011601.1 hypothetical protein 1698359 7064474 E2348C_1635 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329158.1 1697259 D 574521 CDS YP_002329159.1 215486728 7064475 1698837..1700663 1 NC_011601.1 hypothetical protein 1700663 7064475 E2348C_1636 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329159.1 1698837 D 574521 CDS YP_002329160.1 215486729 7061146 1701660..1702061 1 NC_011601.1 reverse transcriptase 1702061 7061146 E2348C_1637 Escherichia coli O127:H6 str. E2348/69 reverse transcriptase YP_002329160.1 1701660 D 574521 CDS YP_002329161.1 215486730 7064477 complement(1702682..1704004) 1 NC_011601.1 regulator with hipB 1704004 hipA 7064477 hipA Escherichia coli O127:H6 str. E2348/69 regulator with hipB YP_002329161.1 1702682 R 574521 CDS YP_002329162.1 215486731 7062141 complement(1704004..1704270) 1 NC_011601.1 DNA-binding transcriptional regulator HipB 1704270 hipB 7062141 hipB Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator HipB YP_002329162.1 1704004 R 574521 CDS YP_002329163.1 215486732 7062142 1704577..1705335 1 NC_011601.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1705335 tam 7062142 tam Escherichia coli O127:H6 str. E2348/69 trans-aconitate 2-methyltransferase YP_002329163.1 1704577 D 574521 CDS YP_002329164.1 215486733 7061751 complement(1705339..1706253) 1 NC_011601.1 hypothetical protein 1706253 yneE 7061751 yneE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329164.1 1705339 R 574521 CDS YP_002329165.1 215486734 7062047 complement(1706450..1707901) 1 NC_011601.1 catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1707901 uxaB 7062047 uxaB Escherichia coli O127:H6 str. E2348/69 altronate oxidoreductase YP_002329165.1 1706450 R 574521 CDS YP_002329166.1 215486735 7062346 complement(1708128..1709546) 1 NC_011601.1 diguanylate cyclase 1709546 yneF 7062346 yneF Escherichia coli O127:H6 str. E2348/69 diguanylate cyclase YP_002329166.1 1708128 R 574521 CDS YP_002329167.1 215486736 7062048 complement(1709685..1710044) 1 NC_011601.1 hypothetical protein 1710044 yneG 7062048 yneG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329167.1 1709685 R 574521 CDS YP_002329168.1 215486737 7062049 complement(1710044..1710970) 1 NC_011601.1 catalyzes the formation of glutamate from glutamine; glutaminase 1710970 yneH 7062049 yneH Escherichia coli O127:H6 str. E2348/69 glutaminase YP_002329168.1 1710044 R 574521 CDS YP_002329169.1 215486738 7062050 complement(1711034..1712422) 1 NC_011601.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; succinate semialdehyde dehydrogenase 1712422 yneI 7062050 yneI Escherichia coli O127:H6 str. E2348/69 succinate semialdehyde dehydrogenase YP_002329169.1 1711034 R 574521 CDS YP_002329170.1 215486739 7062051 1712523..1713404 1 NC_011601.1 DNA-binding transcriptional regulator 1713404 yneJ 7062051 yneJ Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329170.1 1712523 D 574521 CDS YP_002329171.1 215486740 7062052 1713743..1714933 1 NC_011601.1 sugar efflux transporter 1714933 ydeA 7062052 ydeA Escherichia coli O127:H6 str. E2348/69 sugar efflux transporter YP_002329171.1 1713743 D 574521 CDS YP_002329172.1 215486741 7062999 complement(1714958..1715623) 1 NC_011601.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1715623 marC 7062999 marC Escherichia coli O127:H6 str. E2348/69 multiple drug resistance protein MarC YP_002329172.1 1714958 R 574521 CDS YP_002329173.1 215486742 7065293 1715835..1716269 1 NC_011601.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1716269 marR 7065293 marR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor MarR YP_002329173.1 1715835 D 574521 CDS YP_002329174.1 215486743 7065294 1716290..1716673 1 NC_011601.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1716673 marA 7065294 marA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator MarA YP_002329174.1 1716290 D 574521 CDS YP_002329175.1 215486744 7065291 1716705..1716923 1 NC_011601.1 hypothetical protein 1716923 marB 7065291 marB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329175.1 1716705 D 574521 CDS YP_002329176.1 215486745 7065292 complement(1716954..1717853) 1 NC_011601.1 O-acetylserine/cysteine export protein 1717853 eamA 7065292 eamA Escherichia coli O127:H6 str. E2348/69 O-acetylserine/cysteine export protein YP_002329176.1 1716954 R 574521 CDS YP_002329177.1 215486746 7065078 1718048..1719235 1 NC_011601.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; MFS-type transporter YdeE 1719235 ydeE 7065078 ydeE Escherichia coli O127:H6 str. E2348/69 MFS-type transporter YdeE YP_002329177.1 1718048 D 574521 CDS YP_002329178.1 215486747 7063000 1719362..1719457 1 NC_011601.1 hypothetical protein 1719457 yneM 7063000 yneM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329178.1 1719362 D 574521 CDS YP_002329179.1 215486748 7062053 complement(1719676..1720566) 1 NC_011601.1 hypothetical protein 1720566 ydeH 7062053 ydeH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329179.1 1719676 R 574521 CDS YP_002329180.1 215486749 7063002 complement(1721073..1723118) 1 NC_011601.1 dipeptidyl carboxypeptidase II 1723118 dcp 7063002 dcp Escherichia coli O127:H6 str. E2348/69 dipeptidyl carboxypeptidase II YP_002329180.1 1721073 R 574521 CDS YP_002329181.1 215486750 7065228 1723255..1724001 1 NC_011601.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1724001 ydfG 7065228 ydfG Escherichia coli O127:H6 str. E2348/69 3-hydroxy acid dehydrogenase YP_002329181.1 1723255 D 574521 CDS YP_002329182.1 215486751 7063010 1724090..1724776 1 NC_011601.1 DNA-binding transcriptional regulator 1724776 ydfH 7063010 ydfH Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329182.1 1724090 D 574521 CDS YP_002329183.1 215486752 7063011 1724953..1725156 1 NC_011601.1 hypothetical protein 1725156 ydfZ 7063011 ydfZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329183.1 1724953 D 574521 CDS YP_002329184.1 215486753 7063014 complement(1725192..1726652) 1 NC_011601.1 mannonate dehydrogenase 1726652 ydfI 7063014 ydfI Escherichia coli O127:H6 str. E2348/69 mannonate dehydrogenase YP_002329184.1 1725192 R 574521 CDS YP_002329185.1 215486754 7063012 complement(1726741..1728108) 1 NC_011601.1 transporter 1728108 ydfJ 7063012 ydfJ Escherichia coli O127:H6 str. E2348/69 transporter YP_002329185.1 1726741 R 574521 CDS YP_002329186.1 215486755 7063013 complement(1728166..1729185) 1 NC_011601.1 dehydrogenase 1729185 rspB 7063013 rspB Escherichia coli O127:H6 str. E2348/69 dehydrogenase YP_002329186.1 1728166 R 574521 CDS YP_002329187.1 215486756 7064561 complement(1729197..1730411) 1 NC_011601.1 dehydratase 1730411 rspA 7064561 rspA Escherichia coli O127:H6 str. E2348/69 dehydratase YP_002329187.1 1729197 R 574521 CDS YP_002329188.1 215486757 7064560 complement(1730617..1730943) 1 NC_011601.1 hypothetical protein 1730943 ynfA 7064560 ynfA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329188.1 1730617 R 574521 CDS YP_002329189.1 215486758 7062054 1731078..1731419 1 NC_011601.1 hypothetical protein 1731419 ynfB 7062054 ynfB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329189.1 1731078 D 574521 CDS YP_002329190.1 215486759 7061180 1731454..1732014 1 NC_011601.1 spermidine N1-acetyltransferase 1732014 speG 7061180 speG Escherichia coli O127:H6 str. E2348/69 spermidine N1-acetyltransferase YP_002329190.1 1731454 D 574521 CDS YP_002329191.1 215486760 7062746 complement(1732017..1732727) 1 NC_011601.1 hypothetical protein 1732727 ynfC 7062746 ynfC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329191.1 1732017 R 574521 CDS YP_002329192.1 215486761 7061181 1732835..1733140 1 NC_011601.1 hypothetical protein 1733140 ynfD 7061181 ynfD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329192.1 1732835 D 574521 CDS YP_002329193.1 215486762 7061182 1733339..1735765 1 NC_011601.1 oxidoreductase subunit 1735765 ynfE 7061182 ynfE Escherichia coli O127:H6 str. E2348/69 oxidoreductase subunit YP_002329193.1 1733339 D 574521 CDS YP_002329194.1 215486763 7061183 1735853..1738249 1 NC_011601.1 oxidoreductase subunit 1738249 ynfF 7061183 ynfF Escherichia coli O127:H6 str. E2348/69 oxidoreductase subunit YP_002329194.1 1735853 D 574521 CDS YP_002329195.1 215486764 7061184 1738260..1738877 1 NC_011601.1 oxidoreductase, Fe-S subunit 1738877 ynfG 7061184 ynfG Escherichia coli O127:H6 str. E2348/69 oxidoreductase, Fe-S subunit YP_002329195.1 1738260 D 574521 CDS YP_002329196.1 215486765 7061185 1738879..1739733 1 NC_011601.1 oxidoreductase, membrane subunit 1739733 ynfH 7061185 ynfH Escherichia coli O127:H6 str. E2348/69 oxidoreductase, membrane subunit YP_002329196.1 1738879 D 574521 CDS YP_002329197.1 215486766 7061186 1739776..1740390 1 NC_011601.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1740390 dmsD 7061186 dmsD Escherichia coli O127:H6 str. E2348/69 twin-argninine leader-binding protein DmsD YP_002329197.1 1739776 D 574521 CDS YP_002329198.1 215486767 7065043 1740586..1741842 1 NC_011601.1 voltage-gated ClC-type chloride channel ClcB 1741842 clcB 7065043 clcB Escherichia coli O127:H6 str. E2348/69 voltage-gated ClC-type chloride channel ClcB YP_002329198.1 1740586 D 574521 CDS YP_002329199.1 215486768 7062807 complement(1741839..1742492) 1 NC_011601.1 dethiobiotin synthetase, with altered C-ter by frameshift mutation 1742492 ynfK 7062807 ynfK Escherichia coli O127:H6 str. E2348/69 dethiobiotin synthetase, with altered C-ter by frameshift mutation YP_002329199.1 1741839 R 574521 CDS YP_002329200.1 215486769 7061187 complement(1742617..1743837) 1 NC_011601.1 DNA-binding transcriptional repressor 1743837 dgsA 7061187 dgsA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor YP_002329200.1 1742617 R 574521 CDS YP_002329201.1 215486770 7065019 complement(1743972..1744865) 1 NC_011601.1 DNA-binding transcriptional regulator 1744865 ynfL 7065019 ynfL Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329201.1 1743972 R 574521 CDS YP_002329202.1 215486771 7061188 1744972..1746225 1 NC_011601.1 transporter 1746225 ynfM 7061188 ynfM Escherichia coli O127:H6 str. E2348/69 transporter YP_002329202.1 1744972 D 574521 CDS YP_002329203.1 215486772 7061189 1746650..1746958 1 NC_011601.1 required for growth and survival under moderately acid conditions; acid shock protein 1746958 asr 7061189 asr Escherichia coli O127:H6 str. E2348/69 acid shock protein YP_002329203.1 1746650 D 574521 CDS YP_002329204.1 215486773 7062464 1747051..1747134 1 NC_011601.1 membrane protein 1747134 ydgU 7062464 ydgU Escherichia coli O127:H6 str. E2348/69 membrane protein YP_002329204.1 1747051 D 574521 CDS YP_002329205.1 215486774 7063022 1747234..1748055 1 NC_011601.1 peptidase 1748055 ydgD 7063022 ydgD Escherichia coli O127:H6 str. E2348/69 peptidase YP_002329205.1 1747234 D 574521 CDS YP_002329206.1 215486775 7063017 complement(1748094..1748423) 1 NC_011601.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 1748423 mdtI 7063017 mdtI Escherichia coli O127:H6 str. E2348/69 multidrug efflux system protein MdtI YP_002329206.1 1748094 R 574521 CDS YP_002329207.1 215486776 7065314 complement(1748410..1748775) 1 NC_011601.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 1748775 mdtJ 7065314 mdtJ Escherichia coli O127:H6 str. E2348/69 multidrug efflux system protein MdtJ YP_002329207.1 1748410 R 574521 CDS YP_002329208.1 215486777 7065315 1749187..1750221 1 NC_011601.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transporter 1750221 tqsA 7065315 tqsA Escherichia coli O127:H6 str. E2348/69 transporter YP_002329208.1 1749187 D 574521 CDS YP_002329209.1 215486778 7062232 complement(1750246..1751634) 1 NC_011601.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1751634 pntB 7062232 pntB Escherichia coli O127:H6 str. E2348/69 pyridine nucleotide transhydrogenase YP_002329209.1 1750246 R 574521 CDS YP_002329210.1 215486779 7060765 complement(1751645..1753177) 1 NC_011601.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1753177 pntA 7060765 pntA Escherichia coli O127:H6 str. E2348/69 NAD(P) transhydrogenase subunit alpha YP_002329210.1 1751645 R 574521 CDS YP_002329211.1 215486780 7060764 1753701..1754645 1 NC_011601.1 hypothetical protein 1754645 ydgH 7060764 ydgH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329211.1 1753701 D 574521 CDS YP_002329212.1 215486781 7063018 1754831..1756213 1 NC_011601.1 arginine/ornithine antiporter 1756213 ydgI 7063018 ydgI Escherichia coli O127:H6 str. E2348/69 arginine/ornithine antiporter YP_002329212.1 1754831 D 574521 CDS YP_002329213.1 215486782 7063019 1756250..1756972 1 NC_011601.1 short chain dehydrogenase 1756972 folM 7063019 folM Escherichia coli O127:H6 str. E2348/69 short chain dehydrogenase YP_002329213.1 1756250 D 574521 CDS YP_002329214.1 215486783 7061944 complement(1756969..1757304) 1 NC_011601.1 hypothetical protein 1757304 ydgC 7061944 ydgC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329214.1 1756969 R 574521 CDS YP_002329215.1 215486784 7063016 1757433..1758152 1 NC_011601.1 response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1758152 rstA 7063016 rstA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator RstA YP_002329215.1 1757433 D 574521 CDS YP_002329216.1 215486785 7064564 1758156..1759457 1 NC_011601.1 sensor protein RstB 1759457 rstB 7064564 rstB Escherichia coli O127:H6 str. E2348/69 sensor protein RstB YP_002329216.1 1758156 D 574521 CDS YP_002329217.1 215486786 7064565 1759533..1760462 1 NC_011601.1 binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1760462 tus 7064565 tus Escherichia coli O127:H6 str. E2348/69 DNA replication terminus site-binding protein YP_002329217.1 1759533 D 574521 CDS YP_002329218.1 215486787 7062281 complement(1760459..1761862) 1 NC_011601.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1761862 fumC 7062281 fumC Escherichia coli O127:H6 str. E2348/69 fumarate hydratase YP_002329218.1 1760459 R 574521 CDS YP_002329219.1 215486788 7061602 complement(1762005..1763651) 1 NC_011601.1 fumarate hydratase (fumarase A), aerobic ClassI 1763651 fumA 7061602 fumA Escherichia coli O127:H6 str. E2348/69 fumarate hydratase (fumarase A), aerobic ClassI YP_002329219.1 1762005 R 574521 CDS YP_002329220.1 215486789 7061600 1763850..1765025 1 NC_011601.1 mannose-6-phosphate isomerase 1765025 manA 7061600 manA Escherichia coli O127:H6 str. E2348/69 mannose-6-phosphate isomerase YP_002329220.1 1763850 D 574521 CDS YP_002329221.1 215486790 7065283 1765126..1766634 1 NC_011601.1 hypothetical protein 1766634 ydgA 7065283 ydgA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329221.1 1765126 D 574521 CDS YP_002329222.1 215486791 7062314 complement(1767983..1769356) 1 NC_011601.1 glucuronide transporter 1769356 uidB 7062314 uidB Escherichia coli O127:H6 str. E2348/69 glucuronide transporter YP_002329222.1 1767983 R 574521 CDS YP_002329223.1 215486792 7062313 complement(1769353..1771164) 1 NC_011601.1 beta-D-glucuronidase 1771164 uidA 7062313 uidA Escherichia coli O127:H6 str. E2348/69 beta-D-glucuronidase YP_002329223.1 1769353 R 574521 CDS YP_002329224.1 215486793 7062312 complement(1771554..1772144) 1 NC_011601.1 DNA-binding transcriptional repressor 1772144 uidR 7062312 uidR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor YP_002329224.1 1771554 R 574521 CDS YP_002329225.1 215486794 7062315 complement(1772373..1773140) 1 NC_011601.1 Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 1773140 hdhA 7062315 hdhA Escherichia coli O127:H6 str. E2348/69 7-alpha-hydroxysteroid dehydrogenase YP_002329225.1 1772373 R 574521 CDS YP_002329226.1 215486795 7064289 complement(1773252..1774280) 1 NC_011601.1 regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 1774280 malI 7064289 malI Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor MalI YP_002329226.1 1773252 R 574521 CDS YP_002329227.1 215486796 7065273 1774455..1776047 1 NC_011601.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 1776047 malX 7065273 malX Escherichia coli O127:H6 str. E2348/69 bifunctional PTS system maltose and glucose-specific transporter subunits IICB YP_002329227.1 1774455 D 574521 CDS YP_002329228.1 215486797 7065280 1776057..1777229 1 NC_011601.1 bifunctional beta-cystathionase, PLP-dependent/regulator of maltose regulon 1777229 malY 7065280 malY Escherichia coli O127:H6 str. E2348/69 bifunctional beta-cystathionase, PLP-dependent/regulator of maltose regulon YP_002329228.1 1776057 D 574521 CDS YP_002329229.1 215486798 7065281 1777333..1778334 1 NC_011601.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 1778334 add 7065281 add Escherichia coli O127:H6 str. E2348/69 adenosine deaminase YP_002329229.1 1777333 D 574521 CDS YP_002329230.1 215486799 7065002 complement(1778446..1778904) 1 NC_011601.1 transposase of IS200C 1778904 7065002 E2348C_1709 Escherichia coli O127:H6 str. E2348/69 transposase of IS200C YP_002329230.1 1778446 R 574521 CDS YP_002329231.1 215486800 7064478 complement(1779082..1780122) 1 NC_011601.1 oxidoreductase 1780122 ydgJ 7064478 ydgJ Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002329231.1 1779082 R 574521 CDS YP_002329232.1 215486801 7063020 1780365..1780490 1 NC_011601.1 beta-lactam resistance membrane protein Blr 1780490 blr 7063020 blr Escherichia coli O127:H6 str. E2348/69 beta-lactam resistance membrane protein Blr YP_002329232.1 1780365 D 574521 CDS YP_002329233.1 215486802 7062529 1780763..1780978 1 NC_011601.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1780978 cnu 7062529 cnu Escherichia coli O127:H6 str. E2348/69 oriC-binding nucleoid-associated protein YP_002329233.1 1780763 D 574521 CDS YP_002329234.1 215486803 7062820 1781064..1781504 1 NC_011601.1 hypothetical protein 1781504 ydgK 7062820 ydgK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329234.1 1781064 D 574521 CDS YP_002329235.1 215486804 7063021 1781581..1782162 1 NC_011601.1 Na(+)-translocating NADH-quinone reductase subunit E 1782162 rsxA 7063021 rsxA Escherichia coli O127:H6 str. E2348/69 Na(+)-translocating NADH-quinone reductase subunit E YP_002329235.1 1781581 D 574521 CDS YP_002329236.1 215486805 7064567 1782162..1782740 1 NC_011601.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1782740 rsxB 7064567 rsxB Escherichia coli O127:H6 str. E2348/69 electron transport complex protein RnfB YP_002329236.1 1782162 D 574521 CDS YP_002329237.1 215486806 7064568 1782733..1784958 1 NC_011601.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1784958 rsxC 7064568 rsxC Escherichia coli O127:H6 str. E2348/69 electron transport complex protein RnfC YP_002329237.1 1782733 D 574521 CDS YP_002329238.1 215486807 7064569 1784959..1786017 1 NC_011601.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1786017 rnfD 7064569 rnfD Escherichia coli O127:H6 str. E2348/69 electron transport complex protein RnfD YP_002329238.1 1784959 D 574521 CDS YP_002329239.1 215486808 7064570 1786021..1786641 1 NC_011601.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1786641 rsxG 7064570 rsxG Escherichia coli O127:H6 str. E2348/69 electron transport complex protein RnfG YP_002329239.1 1786021 D 574521 CDS YP_002329240.1 215486809 7064572 1786645..1787340 1 NC_011601.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex protein RsxE 1787340 rsxE 7064572 rsxE Escherichia coli O127:H6 str. E2348/69 electron transport complex protein RsxE YP_002329240.1 1786645 D 574521 CDS YP_002329241.1 215486810 7064571 1787340..1787975 1 NC_011601.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1787975 nth 7064571 nth Escherichia coli O127:H6 str. E2348/69 endonuclease III YP_002329241.1 1787340 D 574521 CDS YP_002329242.1 215486811 7065426 1788586..1790088 1 NC_011601.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 1790088 tppB 7065426 tppB Escherichia coli O127:H6 str. E2348/69 tripeptide transporter permease YP_002329242.1 1788586 D 574521 CDS YP_002329243.1 215486812 7062230 1790194..1790799 1 NC_011601.1 glutathionine S-transferase 1790799 gst 7062230 gst Escherichia coli O127:H6 str. E2348/69 glutathionine S-transferase YP_002329243.1 1790194 D 574521 CDS YP_002329244.1 215486813 7064269 complement(1790843..1791703) 1 NC_011601.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1791703 pdxY 7064269 pdxY Escherichia coli O127:H6 str. E2348/69 pyridoxamine kinase YP_002329244.1 1790843 R 574521 CDS YP_002329245.1 215486814 7062944 complement(1791765..1793039) 1 NC_011601.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1793039 tyrS 7062944 tyrS Escherichia coli O127:H6 str. E2348/69 tyrosyl-tRNA synthetase YP_002329245.1 1791765 R 574521 CDS YP_002329246.1 215486815 7062287 complement(1793168..1793824) 1 NC_011601.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1793824 pdxH 7062287 pdxH Escherichia coli O127:H6 str. E2348/69 pyridoxamine 5'-phosphate oxidase YP_002329246.1 1793168 R 574521 CDS YP_002329247.1 215486816 7062941 complement(1793883..1794206) 1 NC_011601.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor 1794206 ydhA 7062941 ydhA Escherichia coli O127:H6 str. E2348/69 lysozyme inhibitor YP_002329247.1 1793883 R 574521 CDS YP_002329248.1 215486817 7063023 complement(1794310..1795419) 1 NC_011601.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1795419 anmK 7063023 anmK Escherichia coli O127:H6 str. E2348/69 anhydro-N-acetylmuramic acid kinase YP_002329248.1 1794310 R 574521 CDS YP_002329249.1 215486818 7061343 1795693..1796160 1 NC_011601.1 outer membrane lipoprotein 1796160 slyB 7061343 slyB Escherichia coli O127:H6 str. E2348/69 outer membrane lipoprotein YP_002329249.1 1795693 D 574521 CDS YP_002329250.1 215486819 7062724 complement(1796207..1796641) 1 NC_011601.1 Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 1796641 slyA 7062724 slyA Escherichia coli O127:H6 str. E2348/69 transcriptional regulator SlyA YP_002329250.1 1796207 R 574521 CDS YP_002329251.1 215486820 7062723 1796842..1797078 1 NC_011601.1 hypothetical protein 1797078 ydhI 7062723 ydhI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329251.1 1796842 D 574521 CDS YP_002329252.1 215486821 7063988 1797081..1797938 1 NC_011601.1 undecaprenyl pyrophosphate phosphatase 1797938 ydhJ 7063988 ydhJ Escherichia coli O127:H6 str. E2348/69 undecaprenyl pyrophosphate phosphatase YP_002329252.1 1797081 D 574521 CDS YP_002329253.1 215486822 7063989 1797938..1799950 1 NC_011601.1 hypothetical protein 1799950 ydhK 7063989 ydhK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329253.1 1797938 D 574521 CDS YP_002329254.1 215486823 7063990 complement(1799951..1800472) 1 NC_011601.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 1800472 sodC 7063990 sodC Escherichia coli O127:H6 str. E2348/69 superoxide dismutase YP_002329254.1 1799951 R 574521 CDS YP_002329255.1 215486824 7062734 complement(1800553..1801449) 1 NC_011601.1 oxidoreductase 1801449 ydhF 7062734 ydhF Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002329255.1 1800553 R 574521 CDS YP_002329256.1 215486825 7063026 complement(1801498..1801737) 1 NC_011601.1 hypothetical protein 1801737 ydhL 7063026 ydhL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329256.1 1801498 R 574521 CDS YP_002329257.1 215486826 7063991 1801840..1802439 1 NC_011601.1 DNA-binding transcriptional regulator 1802439 ydhM 7063991 ydhM Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329257.1 1801840 D 574521 CDS YP_002329258.1 215486827 7063992 1802476..1803573 1 NC_011601.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1803573 nemA 7063992 nemA Escherichia coli O127:H6 str. E2348/69 N-ethylmaleimide reductase YP_002329258.1 1802476 D 574521 CDS YP_002329259.1 215486828 7065379 1803654..1804061 1 NC_011601.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1804061 gloA 7065379 gloA Escherichia coli O127:H6 str. E2348/69 glyoxalase I YP_002329259.1 1803654 D 574521 CDS YP_002329260.1 215486829 7061690 1804164..1804811 1 NC_011601.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1804811 rnt 7061690 rnt Escherichia coli O127:H6 str. E2348/69 ribonuclease T YP_002329260.1 1804164 D 574521 CDS YP_002329261.1 215486830 7061821 complement(1805183..1805530) 1 NC_011601.1 hypothetical protein 1805530 grxD 7061821 grxD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329261.1 1805183 R 574521 CDS YP_002329262.1 215486831 7064249 1805865..1806692 1 NC_011601.1 lipoprotein 1806692 ydhO 7064249 ydhO Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002329262.1 1805865 D 574521 CDS YP_002329263.1 215486832 7063993 1806820..1807401 1 NC_011601.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1807401 sodB 7063993 sodB Escherichia coli O127:H6 str. E2348/69 superoxide dismutase YP_002329263.1 1806820 D 574521 CDS YP_002329264.1 215486833 7062733 complement(1807547..1808716) 1 NC_011601.1 transporter 1808716 ydhP 7062733 ydhP Escherichia coli O127:H6 str. E2348/69 transporter YP_002329264.1 1807547 R 574521 CDS YP_002329265.1 215486834 7063994 complement(1808882..1808971) 1 NC_011601.1 membrane protein 1808971 ynhF 7063994 ynhF Escherichia coli O127:H6 str. E2348/69 membrane protein YP_002329265.1 1808882 R 574521 CDS YP_002329266.1 215486835 7061190 1809270..1810295 1 NC_011601.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1810295 purR 7061190 purR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor PurR YP_002329266.1 1809270 D 574521 CDS YP_002329267.1 215486836 7063922 complement(1810292..1811224) 1 NC_011601.1 DNA-binding transcriptional regulator 1811224 ydhB 7063922 ydhB Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329267.1 1810292 R 574521 CDS YP_002329268.1 215486837 7063024 1811337..1812548 1 NC_011601.1 uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1812548 ydhC 7063024 ydhC Escherichia coli O127:H6 str. E2348/69 inner membrane transport protein YdhC YP_002329268.1 1811337 D 574521 CDS YP_002329269.1 215486838 7063025 1812833..1813981 1 NC_011601.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane-fatty-acyl-phospholipid synthase 1813981 cfa 7063025 cfa Escherichia coli O127:H6 str. E2348/69 cyclopropane-fatty-acyl-phospholipid synthase YP_002329269.1 1812833 D 574521 CDS YP_002329270.1 215486839 7064349 complement(1814021..1814662) 1 NC_011601.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1814662 ribC 7064349 ribC Escherichia coli O127:H6 str. E2348/69 riboflavin synthase subunit alpha YP_002329270.1 1814021 R 574521 CDS YP_002329271.1 215486840 7060820 1814877..1816250 1 NC_011601.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1816250 mdtK 7060820 mdtK Escherichia coli O127:H6 str. E2348/69 multidrug efflux protein YP_002329271.1 1814877 D 574521 CDS YP_002329272.1 215486841 7065316 complement(1816291..1817547) 1 NC_011601.1 hypothetical protein 1817547 ydhQ 7065316 ydhQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329272.1 1816291 R 574521 CDS YP_002329273.1 215486842 7062356 1818124..1818429 1 NC_011601.1 hypothetical protein 1818429 ydhR 7062356 ydhR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329273.1 1818124 D 574521 CDS YP_002329274.1 215486843 7063996 1818555..1820159 1 NC_011601.1 hypothetical protein 1820159 ydhS 7063996 ydhS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329274.1 1818555 D 574521 CDS YP_002329275.1 215486844 7063997 complement(1820171..1820935) 1 NC_011601.1 hypothetical protein 1820935 ydhT 7063997 ydhT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329275.1 1820171 R 574521 CDS YP_002329276.1 215486845 7063998 complement(1820987..1821772) 1 NC_011601.1 cytochrome 1821772 ydhU 7063998 ydhU Escherichia coli O127:H6 str. E2348/69 cytochrome YP_002329276.1 1820987 R 574521 CDS YP_002329277.1 215486846 7063999 complement(1821769..1822488) 1 NC_011601.1 4Fe-4S ferredoxin 1822488 ydhX 7063999 ydhX Escherichia coli O127:H6 str. E2348/69 4Fe-4S ferredoxin YP_002329277.1 1821769 R 574521 CDS YP_002329278.1 215486847 7064002 complement(1822501..1823139) 1 NC_011601.1 hypothetical protein 1823139 ydhW 7064002 ydhW Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329278.1 1822501 R 574521 CDS YP_002329279.1 215486848 7064001 complement(1823152..1825254) 1 NC_011601.1 oxidoreductase 1825254 ydhV 7064001 ydhV Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002329279.1 1823152 R 574521 CDS YP_002329280.1 215486849 7064000 complement(1825275..1825901) 1 NC_011601.1 hypothetical protein 1825901 ydhY 7064000 ydhY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329280.1 1825275 R 574521 CDS YP_002329281.1 215486850 7064003 complement(1826357..1826566) 1 NC_011601.1 hypothetical protein 1826566 ydhZ 7064003 ydhZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329281.1 1826357 R 574521 CDS YP_002329282.1 215486851 7064004 1827123..1828535 1 NC_011601.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1828535 pykF 7064004 pykF Escherichia coli O127:H6 str. E2348/69 pyruvate kinase YP_002329282.1 1827123 D 574521 CDS YP_002329283.1 215486852 7063928 1828846..1829082 1 NC_011601.1 murein lipoprotein 1829082 lpp 7063928 lpp Escherichia coli O127:H6 str. E2348/69 murein lipoprotein YP_002329283.1 1828846 D 574521 CDS YP_002329284.1 215486853 7061569 complement(1829145..1830149) 1 NC_011601.1 hypothetical protein 1830149 ynhG 7061569 ynhG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329284.1 1829145 R 574521 CDS YP_002329285.1 215486854 7061191 complement(1830298..1830714) 1 NC_011601.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 1830714 sufE 7061191 sufE Escherichia coli O127:H6 str. E2348/69 cysteine desufuration protein SufE YP_002329285.1 1830298 R 574521 CDS YP_002329286.1 215486855 7062785 complement(1830727..1831947) 1 NC_011601.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 1831947 sufS 7062785 sufS Escherichia coli O127:H6 str. E2348/69 bifunctional cysteine desulfurase/selenocysteine lyase YP_002329286.1 1830727 R 574521 CDS YP_002329287.1 215486856 7061740 complement(1831944..1833215) 1 NC_011601.1 with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD 1833215 sufD 7061740 sufD Escherichia coli O127:H6 str. E2348/69 cysteine desulfurase activator complex subunit SufD YP_002329287.1 1831944 R 574521 CDS YP_002329288.1 215486857 7062784 complement(1833190..1833936) 1 NC_011601.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase 1833936 sufC 7062784 sufC Escherichia coli O127:H6 str. E2348/69 cysteine desulfurase YP_002329288.1 1833190 R 574521 CDS YP_002329289.1 215486858 7062783 complement(1833946..1835433) 1 NC_011601.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1835433 sufB 7062783 sufB Escherichia coli O127:H6 str. E2348/69 cysteine desulfurase activator complex subunit SufB YP_002329289.1 1833946 R 574521 CDS YP_002329290.1 215486859 7062782 complement(1835442..1835810) 1 NC_011601.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 1835810 sufA 7062782 sufA Escherichia coli O127:H6 str. E2348/69 iron-sulfur cluster assembly scaffold protein YP_002329290.1 1835442 R 574521 CDS YP_002329291.1 215486860 7064593 complement(1836359..1836547) 1 NC_011601.1 hypothetical protein 1836547 ydiH 7064593 ydiH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329291.1 1836359 R 574521 CDS YP_002329292.1 215486861 7064009 complement(1836647..1837057) 1 NC_011601.1 hypothetical protein 1837057 ydiI 7064009 ydiI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329292.1 1836647 R 574521 CDS YP_002329293.1 215486862 7064010 complement(1837054..1840110) 1 NC_011601.1 FAD-linked oxidoreductase 1840110 ydiJ 7064010 ydiJ Escherichia coli O127:H6 str. E2348/69 FAD-linked oxidoreductase YP_002329293.1 1837054 R 574521 CDS YP_002329294.1 215486863 7064011 1840499..1841611 1 NC_011601.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; hypothetical protein 1841611 ydiK 7064011 ydiK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329294.1 1840499 D 574521 CDS YP_002329295.1 215486864 7061872 1842040..1842396 1 NC_011601.1 hypothetical protein 1842396 ydiL 7061872 ydiL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329295.1 1842040 D 574521 CDS YP_002329296.1 215486865 7064013 1842496..1843710 1 NC_011601.1 transporter 1843710 ydiM 7064013 ydiM Escherichia coli O127:H6 str. E2348/69 transporter YP_002329296.1 1842496 D 574521 CDS YP_002329297.1 215486866 7064014 1843937..1845202 1 NC_011601.1 transporter 1845202 ydiN 7064014 ydiN Escherichia coli O127:H6 str. E2348/69 transporter YP_002329297.1 1843937 D 574521 CDS YP_002329298.1 215486867 7064015 1845214..1846080 1 NC_011601.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1846080 ydiB 7064015 ydiB Escherichia coli O127:H6 str. E2348/69 quinate/shikimate dehydrogenase YP_002329298.1 1845214 D 574521 CDS YP_002329299.1 215486868 7064006 1846111..1846869 1 NC_011601.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1846869 aroD 7064006 aroD Escherichia coli O127:H6 str. E2348/69 3-dehydroquinate dehydratase YP_002329299.1 1846111 D 574521 CDS YP_002329300.1 215486869 7061392 1847014..1848609 1 NC_011601.1 fused acetyl-CoA: acetoacetyl-CoA transferase: alpha subunit/beta subunit 1848609 ydiF 7061392 ydiF Escherichia coli O127:H6 str. E2348/69 fused acetyl-CoA: acetoacetyl-CoA transferase: alpha subunit/beta subunit YP_002329300.1 1847014 D 574521 CDS YP_002329301.1 215486870 7064008 1848623..1849774 1 NC_011601.1 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; acyl-CoA dehydrogenase 1849774 ydiO 7064008 ydiO Escherichia coli O127:H6 str. E2348/69 acyl-CoA dehydrogenase YP_002329301.1 1848623 D 574521 CDS YP_002329302.1 215486871 7064016 complement(1849817..1850728) 1 NC_011601.1 DNA-binding transcriptional regulator 1850728 ydiP 7064016 ydiP Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329302.1 1849817 R 574521 CDS YP_002329303.1 215486872 7064017 1851044..1851808 1 NC_011601.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; electron transfer flavoprotein YdiQ 1851808 ydiQ 7064017 ydiQ Escherichia coli O127:H6 str. E2348/69 electron transfer flavoprotein YdiQ YP_002329303.1 1851044 D 574521 CDS YP_002329304.1 215486873 7064018 1851828..1852766 1 NC_011601.1 May play a role in a redox process; electron transfer flavoprotein subunit YdiR 1852766 ydiR 7064018 ydiR Escherichia coli O127:H6 str. E2348/69 electron transfer flavoprotein subunit YdiR YP_002329304.1 1851828 D 574521 CDS YP_002329305.1 215486874 7064019 1852821..1854110 1 NC_011601.1 hypothetical protein 1854110 ydiS 7064019 ydiS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329305.1 1852821 D 574521 CDS YP_002329306.1 215486875 7064020 1854107..1854400 1 NC_011601.1 4Fe-4S ferredoxin 1854400 ydiT 7064020 ydiT Escherichia coli O127:H6 str. E2348/69 4Fe-4S ferredoxin YP_002329306.1 1854107 D 574521 CDS YP_002329307.1 215486876 7064021 1854457..1856103 1 NC_011601.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 1856103 fadK 7064021 fadK Escherichia coli O127:H6 str. E2348/69 short chain acyl-CoA synthetase YP_002329307.1 1854457 D 574521 CDS YP_002329308.1 215486877 7062078 complement(1856160..1858538) 1 NC_011601.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1858538 pps 7062078 pps Escherichia coli O127:H6 str. E2348/69 phosphoenolpyruvate synthase YP_002329308.1 1856160 R 574521 CDS YP_002329309.1 215486878 7061276 1858871..1859704 1 NC_011601.1 hypothetical protein 1859704 ydiA 7061276 ydiA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329309.1 1858871 D 574521 CDS YP_002329310.1 215486879 7064005 1859861..1860907 1 NC_011601.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1860907 aroH 7064005 aroH Escherichia coli O127:H6 str. E2348/69 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002329310.1 1859861 D 574521 CDS YP_002329311.1 215486880 7061396 1861039..1861230 1 NC_011601.1 hypothetical protein 1861230 ydiE 7061396 ydiE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329311.1 1861039 D 574521 CDS YP_002329312.1 215486881 7064007 complement(1861234..1862670) 1 NC_011601.1 hypothetical protein 1862670 ydiU 7064007 ydiU Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329312.1 1861234 R 574521 CDS YP_002329313.1 215486882 7064022 complement(1862733..1863446) 1 NC_011601.1 hypothetical protein 1863446 ydiV 7064022 ydiV Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329313.1 1862733 R 574521 CDS YP_002329314.1 215486883 7064023 complement(1863693..1864157) 1 NC_011601.1 lipoprotein 1864157 nlpC 7064023 nlpC Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002329314.1 1863693 R 574521 CDS YP_002329315.1 215486884 7065402 complement(1864235..1864984) 1 NC_011601.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1864984 btuD 7065402 btuD Escherichia coli O127:H6 str. E2348/69 vitamin B12-transporter ATPase YP_002329315.1 1864235 R 574521 CDS YP_002329316.1 215486885 7062536 complement(1864984..1865535) 1 NC_011601.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase 1865535 btuE 7062536 btuE Escherichia coli O127:H6 str. E2348/69 glutathione peroxidase YP_002329316.1 1864984 R 574521 CDS YP_002329317.1 215486886 7062537 complement(1865597..1866577) 1 NC_011601.1 with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1866577 btuC 7062537 btuC Escherichia coli O127:H6 str. E2348/69 vtamin B12-transporter permease YP_002329317.1 1865597 R 574521 CDS YP_002329318.1 215486887 7061171 complement(1867173..1868147) 1 NC_011601.1 integrase 1868147 7061171 E2348C_1797 Escherichia coli O127:H6 str. E2348/69 integrase YP_002329318.1 1867173 R 574521 CDS YP_002329319.1 215486888 7064479 complement(1868197..1868505) 1 NC_011601.1 repressor protein 1868505 7064479 E2348C_1798 Escherichia coli O127:H6 str. E2348/69 repressor protein YP_002329319.1 1868197 R 574521 CDS YP_002329320.1 215486889 7064480 1868602..1868880 1 NC_011601.1 hypothetical protein 1868880 7064480 E2348C_1799 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329320.1 1868602 D 574521 CDS YP_002329321.1 215486890 7064481 1868895..1869233 1 NC_011601.1 hypothetical protein 1869233 7064481 E2348C_1800 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329321.1 1868895 D 574521 CDS YP_002329322.1 215486891 7064482 1869244..1869531 1 NC_011601.1 hypothetical protein 1869531 7064482 E2348C_1801 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329322.1 1869244 D 574521 CDS YP_002329323.1 215486892 7064483 1869543..1869785 1 NC_011601.1 hypothetical protein 1869785 7064483 E2348C_1802 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329323.1 1869543 D 574521 CDS YP_002329324.1 215486893 7064484 1869982..1870185 1 NC_011601.1 hypothetical protein 1870185 7064484 E2348C_1803 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329324.1 1869982 D 574521 CDS YP_002329325.1 215486894 7064485 1870182..1870427 1 NC_011601.1 hypothetical protein 1870427 7064485 E2348C_1804 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329325.1 1870182 D 574521 CDS YP_002329326.1 215486895 7064486 1870569..1870934 1 NC_011601.1 hypothetical protein 1870934 7064486 E2348C_1805 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329326.1 1870569 D 574521 CDS YP_002329327.1 215486896 7064487 1871079..1873763 1 NC_011601.1 replication protein 1873763 7064487 E2348C_1806 Escherichia coli O127:H6 str. E2348/69 replication protein YP_002329327.1 1871079 D 574521 CDS YP_002329328.1 215486897 7064488 1873840..1874799 1 NC_011601.1 plasmid partition protein 1874799 7064488 E2348C_1807 Escherichia coli O127:H6 str. E2348/69 plasmid partition protein YP_002329328.1 1873840 D 574521 CDS YP_002329329.1 215486898 7064489 1874804..1875115 1 NC_011601.1 plasmid partition protein 1875115 7064489 E2348C_1808 Escherichia coli O127:H6 str. E2348/69 plasmid partition protein YP_002329329.1 1874804 D 574521 CDS YP_002329330.1 215486899 7064490 1875494..1876576 1 NC_011601.1 ATPase, AAA-superfamily 1876576 7064490 E2348C_1809 Escherichia coli O127:H6 str. E2348/69 ATPase, AAA-superfamily YP_002329330.1 1875494 D 574521 CDS YP_002329331.1 215486900 7064491 1876573..1878777 1 NC_011601.1 proteases 1878777 7064491 E2348C_1810 Escherichia coli O127:H6 str. E2348/69 proteases YP_002329331.1 1876573 D 574521 CDS YP_002329332.1 215486901 7064492 complement(1879282..1880328) 1 NC_011601.1 capsid portal protein 1880328 7064492 E2348C_1811 Escherichia coli O127:H6 str. E2348/69 capsid portal protein YP_002329332.1 1879282 R 574521 CDS YP_002329333.1 215486902 7064493 complement(1880328..1882079) 1 NC_011601.1 terminase, ATPase subunit 1882079 7064493 E2348C_1812 Escherichia coli O127:H6 str. E2348/69 terminase, ATPase subunit YP_002329333.1 1880328 R 574521 CDS YP_002329334.1 215486903 7064494 1882234..1883070 1 NC_011601.1 capsid scaffolding protein 1883070 7064494 E2348C_1813 Escherichia coli O127:H6 str. E2348/69 capsid scaffolding protein YP_002329334.1 1882234 D 574521 CDS YP_002329335.1 215486904 7064495 1883094..1884146 1 NC_011601.1 major capsid protein 1884146 7064495 E2348C_1814 Escherichia coli O127:H6 str. E2348/69 major capsid protein YP_002329335.1 1883094 D 574521 CDS YP_002329336.1 215486905 7064496 1884192..1884992 1 NC_011601.1 terminase, endonuclease subunit 1884992 7064496 E2348C_1815 Escherichia coli O127:H6 str. E2348/69 terminase, endonuclease subunit YP_002329336.1 1884192 D 574521 CDS YP_002329337.1 215486906 7064497 1885094..1885588 1 NC_011601.1 capsid completion protein 1885588 7064497 E2348C_1816 Escherichia coli O127:H6 str. E2348/69 capsid completion protein YP_002329337.1 1885094 D 574521 CDS YP_002329338.1 215486907 7064498 1885588..1885788 1 NC_011601.1 tail protein 1885788 7064498 E2348C_1817 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002329338.1 1885588 D 574521 CDS YP_002329339.1 215486908 7064499 1885791..1886114 1 NC_011601.1 holin protein 1886114 7064499 E2348C_1818 Escherichia coli O127:H6 str. E2348/69 holin protein YP_002329339.1 1885791 D 574521 CDS YP_002329340.1 215486909 7064500 1886111..1886503 1 NC_011601.1 endolysin 1886503 7064500 E2348C_1819 Escherichia coli O127:H6 str. E2348/69 endolysin YP_002329340.1 1886111 D 574521 CDS YP_002329341.1 215486910 7064501 1886500..1886907 1 NC_011601.1 hypothetical protein 1886907 7064501 E2348C_1820 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329341.1 1886500 D 574521 CDS YP_002329342.1 215486911 7064502 1887045..1887512 1 NC_011601.1 tail protein 1887512 7064502 E2348C_1821 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002329342.1 1887045 D 574521 CDS YP_002329343.1 215486912 7064503 1887496..1888140 1 NC_011601.1 tail protein 1888140 7064503 E2348C_1822 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002329343.1 1887496 D 574521 CDS YP_002329344.1 215486913 7064504 1888152..1888718 1 NC_011601.1 baseplate assembly protein 1888718 7064504 E2348C_1823 Escherichia coli O127:H6 str. E2348/69 baseplate assembly protein YP_002329344.1 1888152 D 574521 CDS YP_002329345.1 215486914 7064505 1888715..1889065 1 NC_011601.1 baseplate assembly protein 1889065 7064505 E2348C_1824 Escherichia coli O127:H6 str. E2348/69 baseplate assembly protein YP_002329345.1 1888715 D 574521 CDS YP_002329346.1 215486915 7064506 1889069..1889965 1 NC_011601.1 baseplate assembly protein 1889965 7064506 E2348C_1825 Escherichia coli O127:H6 str. E2348/69 baseplate assembly protein YP_002329346.1 1889069 D 574521 CDS YP_002329347.1 215486916 7064507 1889958..1890566 1 NC_011601.1 tail protein 1890566 7064507 E2348C_1826 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002329347.1 1889958 D 574521 CDS YP_002329348.1 215486917 7064508 1890563..1892128 1 NC_011601.1 tail fiber protein 1892128 7064508 E2348C_1827 Escherichia coli O127:H6 str. E2348/69 tail fiber protein YP_002329348.1 1890563 D 574521 CDS YP_002329349.1 215486918 7064509 1892139..1892615 1 NC_011601.1 alternative C-terminus of phage tail fiber protein, fused to tail fiber protein by inversion 1892615 7064509 E2348C_1828 Escherichia coli O127:H6 str. E2348/69 alternative C-terminus of phage tail fiber protein, fused to tail fiber protein by inversion YP_002329349.1 1892139 D 574521 CDS YP_002329350.1 215486919 7064510 complement(1892622..1893233) 1 NC_011601.1 tail fibre assembly protein 1893233 7064510 E2348C_1829 Escherichia coli O127:H6 str. E2348/69 tail fibre assembly protein YP_002329350.1 1892622 R 574521 CDS YP_002329351.1 215486920 7064511 complement(1893233..1893691) 1 NC_011601.1 alternative C-terminus of phage tail fiber protein, fused to tail fiber protein by inversion 1893691 7064511 E2348C_1830 Escherichia coli O127:H6 str. E2348/69 alternative C-terminus of phage tail fiber protein, fused to tail fiber protein by inversion YP_002329351.1 1893233 R 574521 CDS YP_002329352.1 215486921 7064512 1893763..1894362 1 NC_011601.1 DNA invertase 1894362 7064512 E2348C_1831 Escherichia coli O127:H6 str. E2348/69 DNA invertase YP_002329352.1 1893763 D 574521 CDS YP_002329353.1 215486922 7064513 complement(1894389..1894877) 1 NC_011601.1 tail assembly protein 1894877 7064513 E2348C_1832 Escherichia coli O127:H6 str. E2348/69 tail assembly protein YP_002329353.1 1894389 R 574521 CDS YP_002329354.1 215486923 7064514 complement(1894890..1897697) 1 NC_011601.1 phage tail tape measure protein 1897697 7064514 E2348C_1833 Escherichia coli O127:H6 str. E2348/69 phage tail tape measure protein YP_002329354.1 1894890 R 574521 CDS YP_002329355.1 215486924 7064515 complement(1897684..1897920) 1 NC_011601.1 tail protein 1897920 7064515 E2348C_1834 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002329355.1 1897684 R 574521 CDS YP_002329356.1 215486925 7064516 complement(1897848..1898222) 1 NC_011601.1 tail protein 1898222 7064516 E2348C_1835 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002329356.1 1897848 R 574521 CDS YP_002329357.1 215486926 7064517 complement(1898278..1898790) 1 NC_011601.1 tail tube protein 1898790 7064517 E2348C_1836 Escherichia coli O127:H6 str. E2348/69 tail tube protein YP_002329357.1 1898278 R 574521 CDS YP_002329358.1 215486927 7064518 complement(1898790..1899974) 1 NC_011601.1 tail sheath protein 1899974 7064518 E2348C_1837 Escherichia coli O127:H6 str. E2348/69 tail sheath protein YP_002329358.1 1898790 R 574521 CDS YP_002329359.1 215486928 7064519 1900132..1901232 1 NC_011601.1 late gene regulator 1901232 7064519 E2348C_1838 Escherichia coli O127:H6 str. E2348/69 late gene regulator YP_002329359.1 1900132 D 574521 CDS YP_002329360.1 215486929 7064520 1901427..1902092 1 NC_011601.1 hypothetical protein 1902092 7064520 E2348C_1839 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329360.1 1901427 D 574521 CDS YP_002329361.1 215486930 7064521 1902242..1902502 1 NC_011601.1 regulatory protein 1902502 7064521 E2348C_1840 Escherichia coli O127:H6 str. E2348/69 regulatory protein YP_002329361.1 1902242 D 574521 CDS YP_002329362.1 215486931 7064522 complement(1903137..1903436) 1 NC_011601.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1903436 ihfA 7064522 ihfA Escherichia coli O127:H6 str. E2348/69 integration host factor subunit alpha YP_002329362.1 1903137 R 574521 CDS YP_002329363.1 215486932 7063520 complement(1903441..1905828) 1 NC_011601.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1905828 pheT 7063520 pheT Escherichia coli O127:H6 str. E2348/69 phenylalanyl-tRNA synthetase subunit beta YP_002329363.1 1903441 R 574521 CDS YP_002329364.1 215486933 7060725 complement(1905843..1906826) 1 NC_011601.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1906826 pheS 7060725 pheS Escherichia coli O127:H6 str. E2348/69 phenylalanyl-tRNA synthetase subunit alpha YP_002329364.1 1905843 R 574521 CDS YP_002329366.1 215486935 7060722 complement(1907277..1907633) 1 NC_011601.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1907633 rplT 7060722 rplT Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L20 YP_002329366.1 1907277 R 574521 CDS YP_002329367.1 215486936 7061847 complement(1907686..1907883) 1 NC_011601.1 50S ribosomal protein L35 1907883 rpmI 7061847 rpmI Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L35 YP_002329367.1 1907686 R 574521 CDS YP_002329368.1 215486937 7061861 complement(1907980..1908522) 1 NC_011601.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1908522 infC 7061861 infC Escherichia coli O127:H6 str. E2348/69 translation initiation factor IF-3 YP_002329368.1 1907980 R 574521 CDS YP_002329369.1 215486938 7063544 complement(1908526..1910454) 1 NC_011601.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1910454 thrS 7063544 thrS Escherichia coli O127:H6 str. E2348/69 threonyl-tRNA synthetase YP_002329369.1 1908526 R 574521 CDS YP_002329370.1 215486939 7064523 1912165..1912272 1 NC_011601.1 hypothetical protein 1912272 yniD 7064523 yniD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329370.1 1912165 D 574521 CDS YP_002329371.1 215486940 7061195 complement(1912325..1913083) 1 NC_011601.1 hypothetical protein 1913083 ydiY 7061195 ydiY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329371.1 1912325 R 574521 CDS YP_002329372.1 215486941 7064024 1913370..1914299 1 NC_011601.1 6-phosphofructokinase 1914299 pfkB 7064024 pfkB Escherichia coli O127:H6 str. E2348/69 6-phosphofructokinase YP_002329372.1 1913370 D 574521 CDS YP_002329373.1 215486942 7060707 1914400..1914690 1 NC_011601.1 hypothetical protein 1914690 ydiZ 7060707 ydiZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329373.1 1914400 D 574521 CDS YP_002329374.1 215486943 7064025 1914796..1915656 1 NC_011601.1 phosphotransferase/kinase 1915656 yniA 7064025 yniA Escherichia coli O127:H6 str. E2348/69 phosphotransferase/kinase YP_002329374.1 1914796 D 574521 CDS YP_002329375.1 215486944 7061192 complement(1915697..1916233) 1 NC_011601.1 hypothetical protein 1916233 yniB 7061192 yniB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329375.1 1915697 R 574521 CDS YP_002329376.1 215486945 7061193 1916380..1917048 1 NC_011601.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1917048 yniC 7061193 yniC Escherichia coli O127:H6 str. E2348/69 2-deoxyglucose-6-phosphatase YP_002329376.1 1916380 D 574521 CDS YP_002329377.1 215486946 7061194 1917211..1917801 1 NC_011601.1 hypothetical protein 1917801 ydjM 7061194 ydjM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329377.1 1917211 D 574521 CDS YP_002329378.1 215486947 7064035 1917934..1919325 1 NC_011601.1 transporter 1919325 ydjN 7064035 ydjN Escherichia coli O127:H6 str. E2348/69 transporter YP_002329378.1 1917934 D 574521 CDS YP_002329379.1 215486948 7064036 complement(1919372..1919635) 1 NC_011601.1 cell division modulator 1919635 cedA 7064036 cedA Escherichia coli O127:H6 str. E2348/69 cell division modulator YP_002329379.1 1919372 R 574521 CDS YP_002329380.1 215486949 7064344 1919818..1922079 1 NC_011601.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1922079 katE 7064344 katE Escherichia coli O127:H6 str. E2348/69 hydroperoxidase II YP_002329380.1 1919818 D 574521 CDS YP_002329381.1 215486950 7063563 complement(1922125..1922883) 1 NC_011601.1 hypothetical protein 1922883 chbG 7063563 chbG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329381.1 1922125 R 574521 CDS YP_002329382.1 215486951 7064357 complement(1922896..1924248) 1 NC_011601.1 cryptic phospho-beta-glucosidase, NAD(P)-binding 1924248 chbF 7064357 chbF Escherichia coli O127:H6 str. E2348/69 cryptic phospho-beta-glucosidase, NAD(P)-binding YP_002329382.1 1922896 R 574521 CDS YP_002329383.1 215486952 7064356 complement(1924352..1925194) 1 NC_011601.1 represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR 1925194 chbR 7064356 chbR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator ChbR YP_002329383.1 1924352 R 574521 CDS YP_002329384.1 215486953 7064358 complement(1925202..1925552) 1 NC_011601.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 1925552 chbA 7064358 chbA Escherichia coli O127:H6 str. E2348/69 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA YP_002329384.1 1925202 R 574521 CDS YP_002329385.1 215486954 7064353 complement(1925603..1926961) 1 NC_011601.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 1926961 chbC 7064353 chbC Escherichia coli O127:H6 str. E2348/69 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC YP_002329385.1 1925603 R 574521 CDS YP_002329386.1 215486955 7064355 complement(1927046..1927366) 1 NC_011601.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 1927366 chbB 7064355 chbB Escherichia coli O127:H6 str. E2348/69 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB YP_002329386.1 1927046 R 574521 CDS YP_002329387.1 215486956 7064354 complement(1927666..1928004) 1 NC_011601.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1928004 osmE 7064354 osmE Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator OsmE YP_002329387.1 1927666 R 574521 CDS YP_002329388.1 215486957 7062891 1928206..1929033 1 NC_011601.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1929033 nadE 7062891 nadE Escherichia coli O127:H6 str. E2348/69 NAD synthetase YP_002329388.1 1928206 D 574521 CDS YP_002329389.1 215486958 7060908 1929263..1930150 1 NC_011601.1 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1930150 cho 7060908 cho Escherichia coli O127:H6 str. E2348/69 nucleotide excision repair endonuclease YP_002329389.1 1929263 D 574521 CDS YP_002329390.1 215486959 7064365 complement(1930110..1930685) 1 NC_011601.1 hypothetical protein 1930685 vse 7064365 vse Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329390.1 1930110 R 574521 CDS YP_002329391.1 215486960 7062362 complement(1930888..1931373) 1 NC_011601.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; hypothetical protein 1931373 spy 7062362 spy Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329391.1 1930888 R 574521 CDS YP_002329392.1 215486961 7062752 complement(1931703..1932671) 1 NC_011601.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 1932671 astE 7062752 astE Escherichia coli O127:H6 str. E2348/69 succinylglutamate desuccinylase YP_002329392.1 1931703 R 574521 CDS YP_002329393.1 215486962 7062469 complement(1932664..1934007) 1 NC_011601.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase 1934007 astB 7062469 astB Escherichia coli O127:H6 str. E2348/69 succinylarginine dihydrolase YP_002329393.1 1932664 R 574521 CDS YP_002329394.1 215486963 7062466 complement(1934004..1935482) 1 NC_011601.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 1935482 astD 7062466 astD Escherichia coli O127:H6 str. E2348/69 succinylglutamic semialdehyde dehydrogenase YP_002329394.1 1934004 R 574521 CDS YP_002329395.1 215486964 7062468 complement(1935479..1936513) 1 NC_011601.1 arginine succinyltransferase 1936513 astA 7062468 astA Escherichia coli O127:H6 str. E2348/69 arginine succinyltransferase YP_002329395.1 1935479 R 574521 CDS YP_002329396.1 215486965 7062465 complement(1936510..1937730) 1 NC_011601.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase 1937730 astC 7062465 astC Escherichia coli O127:H6 str. E2348/69 bifunctional succinylornithine transaminase/acetylornithine transaminase YP_002329396.1 1936510 R 574521 CDS YP_002329397.1 215486966 7062467 1938176..1938982 1 NC_011601.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1938982 xthA 7062467 xthA Escherichia coli O127:H6 str. E2348/69 exonuclease III YP_002329397.1 1938176 D 574521 CDS YP_002329398.1 215486967 7064868 1939149..1939859 1 NC_011601.1 hypothetical protein 1939859 ydjX 7064868 ydjX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329398.1 1939149 D 574521 CDS YP_002329399.1 215486968 7064037 1939864..1940541 1 NC_011601.1 hypothetical protein 1940541 ydjY 7064037 ydjY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329399.1 1939864 D 574521 CDS YP_002329400.1 215486969 7064038 1940558..1941262 1 NC_011601.1 hypothetical protein 1941262 ydjZ 7064038 ydjZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329400.1 1940558 D 574521 CDS YP_002329401.1 215486970 7064039 1941262..1941810 1 NC_011601.1 hypothetical protein 1941810 ynjA 7064039 ynjA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329401.1 1941262 D 574521 CDS YP_002329402.1 215486971 7061196 1941820..1942986 1 NC_011601.1 ABC transporter substrate-binding protein 1942986 ynjB 7061196 ynjB Escherichia coli O127:H6 str. E2348/69 ABC transporter substrate-binding protein YP_002329402.1 1941820 D 574521 CDS YP_002329403.1 215486972 7061197 1942959..1944494 1 NC_011601.1 fused transporter subunits of ABC superfamily: membrane components 1944494 ynjC 7061197 ynjC Escherichia coli O127:H6 str. E2348/69 fused transporter subunits of ABC superfamily: membrane components YP_002329403.1 1942959 D 574521 CDS YP_002329404.1 215486973 7061198 1944494..1945147 1 NC_011601.1 transporter subunit: ATP-binding component of ABC superfamily 1945147 ynjD 7061198 ynjD Escherichia coli O127:H6 str. E2348/69 transporter subunit: ATP-binding component of ABC superfamily YP_002329404.1 1944494 D 574521 CDS YP_002329405.1 215486974 7061199 1945214..1946521 1 NC_011601.1 thiosulfate sulfur transferase 1946521 ynjE 7061199 ynjE Escherichia coli O127:H6 str. E2348/69 thiosulfate sulfur transferase YP_002329405.1 1945214 D 574521 CDS YP_002329406.1 215486975 7061200 complement(1946530..1947150) 1 NC_011601.1 phosphatidyl transferase, inner membrane protein 1947150 ynjF 7061200 ynjF Escherichia coli O127:H6 str. E2348/69 phosphatidyl transferase, inner membrane protein YP_002329406.1 1946530 R 574521 CDS YP_002329407.1 215486976 7061201 1947237..1947644 1 NC_011601.1 pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1947644 nudG 7061201 nudG Escherichia coli O127:H6 str. E2348/69 pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase YP_002329407.1 1947237 D 574521 CDS YP_002329408.1 215486977 7065431 complement(1947610..1947882) 1 NC_011601.1 hypothetical protein 1947882 ynjH 7065431 ynjH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329408.1 1947610 R 574521 CDS YP_002329409.1 215486978 7061202 1948118..1949461 1 NC_011601.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1949461 gdhA 7061202 gdhA Escherichia coli O127:H6 str. E2348/69 glutamate dehydrogenase YP_002329409.1 1948118 D 574521 CDS YP_002329410.1 215486979 7061647 complement(1949538..1951493) 1 NC_011601.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 1951493 topB 7061647 topB Escherichia coli O127:H6 str. E2348/69 DNA topoisomerase III YP_002329410.1 1949538 R 574521 CDS YP_002329411.1 215486980 7062219 complement(1951498..1952541) 1 NC_011601.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1952541 selD 7062219 selD Escherichia coli O127:H6 str. E2348/69 selenophosphate synthetase YP_002329411.1 1951498 R 574521 CDS YP_002329412.1 215486981 7065362 complement(1952658..1953209) 1 NC_011601.1 hypothetical protein 1953209 ydjA 7065362 ydjA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329412.1 1952658 R 574521 CDS YP_002329413.1 215486982 7064026 1953370..1955226 1 NC_011601.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1955226 sppA 7064026 sppA Escherichia coli O127:H6 str. E2348/69 protease 4 YP_002329413.1 1953370 D 574521 CDS YP_002329414.1 215486983 7062750 1955391..1956407 1 NC_011601.1 converts asparagine to aspartate and ammonia; asparaginase 1956407 ansA 7062750 ansA Escherichia coli O127:H6 str. E2348/69 asparaginase YP_002329414.1 1955391 D 574521 CDS YP_002329415.1 215486984 7061344 1956418..1957059 1 NC_011601.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 1957059 pncA 7061344 pncA Escherichia coli O127:H6 str. E2348/69 nicotinamidase/pyrazinamidase YP_002329415.1 1956418 D 574521 CDS YP_002329416.1 215486985 7060761 complement(1957152..1958510) 1 NC_011601.1 transporter 1958510 ydjE 7060761 ydjE Escherichia coli O127:H6 str. E2348/69 transporter YP_002329416.1 1957152 R 574521 CDS YP_002329417.1 215486986 7064027 complement(1958628..1959386) 1 NC_011601.1 DNA-binding transcriptional regulator 1959386 ydjF 7064027 ydjF Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329417.1 1958628 R 574521 CDS YP_002329418.1 215486987 7064028 complement(1959523..1960503) 1 NC_011601.1 oxidoreductase 1960503 ydjG 7064028 ydjG Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002329418.1 1959523 R 574521 CDS YP_002329419.1 215486988 7064029 complement(1960513..1961460) 1 NC_011601.1 kinase 1961460 ydjH 7064029 ydjH Escherichia coli O127:H6 str. E2348/69 kinase YP_002329419.1 1960513 R 574521 CDS YP_002329420.1 215486989 7064030 complement(1961465..1962301) 1 NC_011601.1 aldolase 1962301 ydjI 7064030 ydjI Escherichia coli O127:H6 str. E2348/69 aldolase YP_002329420.1 1961465 R 574521 CDS YP_002329421.1 215486990 7064031 complement(1962322..1963365) 1 NC_011601.1 oxidoreductase, Zn-dependent and NAD(P)-binding 1963365 ydjJ 7064031 ydjJ Escherichia coli O127:H6 str. E2348/69 oxidoreductase, Zn-dependent and NAD(P)-binding YP_002329421.1 1962322 R 574521 CDS YP_002329422.1 215486991 7064032 complement(1963382..1964761) 1 NC_011601.1 transporter 1964761 ydjK 7064032 ydjK Escherichia coli O127:H6 str. E2348/69 transporter YP_002329422.1 1963382 R 574521 CDS YP_002329423.1 215486992 7064033 complement(1964788..1965864) 1 NC_011601.1 oxidoreductase, Zn-dependent and NAD(P)-binding 1965864 ydjL 7064033 ydjL Escherichia coli O127:H6 str. E2348/69 oxidoreductase, Zn-dependent and NAD(P)-binding YP_002329423.1 1964788 R 574521 CDS YP_002329424.1 215486993 7064034 complement(1966234..1966506) 1 NC_011601.1 hypothetical protein 1966506 yeaC 7064034 yeaC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329424.1 1966234 R 574521 CDS YP_002329425.1 215486994 7064040 complement(1966548..1966961) 1 NC_011601.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1966961 msrB 7064040 msrB Escherichia coli O127:H6 str. E2348/69 methionine sulfoxide reductase B YP_002329425.1 1966548 R 574521 CDS YP_002329426.1 215486995 7060875 1967303..1968298 1 NC_011601.1 glyceraldehyde-3-phosphate dehydrogenase 1968298 gapA 7060875 gapA Escherichia coli O127:H6 str. E2348/69 glyceraldehyde-3-phosphate dehydrogenase YP_002329426.1 1967303 D 574521 CDS YP_002329427.1 215486996 7061625 1968382..1969266 1 NC_011601.1 hypothetical protein 1969266 yeaD 7061625 yeaD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329427.1 1968382 D 574521 CDS YP_002329428.1 215486997 7064041 complement(1969317..1970171) 1 NC_011601.1 oxidoreductase 1970171 yeaE 7064041 yeaE Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002329428.1 1969317 R 574521 CDS YP_002329429.1 215486998 7064042 complement(1970261..1971007) 1 NC_011601.1 scaffolding protein for murein synthesizing machinery 1971007 mipA 7064042 mipA Escherichia coli O127:H6 str. E2348/69 scaffolding protein for murein synthesizing machinery YP_002329429.1 1970261 R 574521 CDS YP_002329430.1 215486999 7063792 1971443..1973377 1 NC_011601.1 hypothetical protein 1973377 yeaG 7063792 yeaG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329430.1 1971443 D 574521 CDS YP_002329431.1 215487000 7064043 1973490..1974773 1 NC_011601.1 hypothetical protein 1974773 yeaH 7064043 yeaH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329431.1 1973490 D 574521 CDS YP_002329432.1 215487001 7064044 1975052..1976395 1 NC_011601.1 diguanylate cyclase 1976395 yeaI 7064044 yeaI Escherichia coli O127:H6 str. E2348/69 diguanylate cyclase YP_002329432.1 1975052 D 574521 CDS YP_002329433.1 215487002 7064045 1976576..1978066 1 NC_011601.1 diguanylate cyclase 1978066 yeaJ 7064045 yeaJ Escherichia coli O127:H6 str. E2348/69 diguanylate cyclase YP_002329433.1 1976576 D 574521 CDS YP_002329434.1 215487003 7064046 1978109..1978612 1 NC_011601.1 hypothetical protein 1978612 yeaK 7064046 yeaK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329434.1 1978109 D 574521 CDS YP_002329435.1 215487004 7064047 complement(1978613..1978717) 1 NC_011601.1 hypothetical protein 1978717 yoaI 7064047 yoaI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329435.1 1978613 R 574521 CDS YP_002329436.1 215487005 7061211 1978887..1979333 1 NC_011601.1 hypothetical protein 1979333 yeaL 7061211 yeaL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329436.1 1978887 D 574521 CDS YP_002329437.1 215487006 7064048 complement(1979290..1980111) 1 NC_011601.1 DNA-binding transcriptional regulator, ARAC-type 1980111 yeaM 7064048 yeaM Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator, ARAC-type YP_002329437.1 1979290 R 574521 CDS YP_002329438.1 215487007 7064049 1980208..1981389 1 NC_011601.1 transporter 1981389 yeaN 7064049 yeaN Escherichia coli O127:H6 str. E2348/69 transporter YP_002329438.1 1980208 D 574521 CDS YP_002329439.1 215487008 7064050 1981444..1981791 1 NC_011601.1 hypothetical protein 1981791 yeaO 7064050 yeaO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329439.1 1981444 D 574521 CDS YP_002329440.1 215487009 7064051 complement(1981813..1982067) 1 NC_011601.1 hypothetical protein 1982067 yoaF 7064051 yoaF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329440.1 1981813 R 574521 CDS YP_002329441.1 215487010 7061208 1982250..1983275 1 NC_011601.1 diguanylate cyclase 1983275 yeaP 7061208 yeaP Escherichia coli O127:H6 str. E2348/69 diguanylate cyclase YP_002329441.1 1982250 D 574521 CDS YP_002329442.1 215487011 7064052 complement(1983543..1983791) 1 NC_011601.1 hypothetical protein 1983791 yeaQ 7064052 yeaQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329442.1 1983543 R 574521 CDS YP_002329443.1 215487012 7064053 complement(1983939..1984121) 1 NC_011601.1 hypothetical protein 1984121 yoaG 7064053 yoaG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329443.1 1983939 R 574521 CDS YP_002329444.1 215487013 7061209 complement(1984125..1984484) 1 NC_011601.1 hypothetical protein 1984484 yeaR 7061209 yeaR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329444.1 1984125 R 574521 CDS YP_002329445.1 215487014 7064054 complement(1984656..1985294) 1 NC_011601.1 leucine export protein LeuE 1985294 leuE 7064054 leuE Escherichia coli O127:H6 str. E2348/69 leucine export protein LeuE YP_002329445.1 1984656 R 574521 CDS YP_002329446.1 215487015 7064055 complement(1985837..1986964) 1 NC_011601.1 ribonuclease D 1986964 rnd 7064055 rnd Escherichia coli O127:H6 str. E2348/69 ribonuclease D YP_002329446.1 1985837 R 574521 CDS YP_002329447.1 215487016 7062757 complement(1987034..1988719) 1 NC_011601.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1988719 fadD 7062757 fadD Escherichia coli O127:H6 str. E2348/69 long-chain-fatty-acid--CoA ligase YP_002329447.1 1987034 R 574521 CDS YP_002329448.1 215487017 7062073 complement(1988924..1989505) 1 NC_011601.1 lipoprotein 1989505 yeaY 7062073 yeaY Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002329448.1 1988924 R 574521 CDS YP_002329449.1 215487018 7064056 complement(1989545..1990240) 1 NC_011601.1 peptidase 1990240 yeaZ 7064056 yeaZ Escherichia coli O127:H6 str. E2348/69 peptidase YP_002329449.1 1989545 R 574521 CDS YP_002329450.1 215487019 7064057 complement(1990298..1992208) 1 NC_011601.1 hypothetical protein 1992208 yoaA 7064057 yoaA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329450.1 1990298 R 574521 CDS YP_002329451.1 215487020 7061203 1992337..1992684 1 NC_011601.1 hypothetical protein 1992684 yoaB 7061203 yoaB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329451.1 1992337 D 574521 CDS YP_002329452.1 215487021 7061204 1993106..1993405 1 NC_011601.1 hypothetical protein 1993405 yoaC 7061204 yoaC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329452.1 1993106 D 574521 CDS YP_002329453.1 215487022 7061205 complement(1993525..1993704) 1 NC_011601.1 hypothetical protein 1993704 yoaH 7061205 yoaH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329453.1 1993525 R 574521 CDS YP_002329454.1 215487023 7061210 1993778..1995139 1 NC_011601.1 aminodeoxychorismate synthase subunit I 1995139 pabB 7061210 pabB Escherichia coli O127:H6 str. E2348/69 aminodeoxychorismate synthase subunit I YP_002329454.1 1993778 D 574521 CDS YP_002329455.1 215487024 7062901 1995143..1995721 1 NC_011601.1 hypothetical protein 1995721 nudL 7062901 nudL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329455.1 1995143 D 574521 CDS YP_002329456.1 215487025 7065436 1995905..1997269 1 NC_011601.1 L-serine deaminase I 1997269 sdaA 7065436 sdaA Escherichia coli O127:H6 str. E2348/69 L-serine deaminase I YP_002329456.1 1995905 D 574521 CDS YP_002329457.1 215487026 7065344 1997400..1998998 1 NC_011601.1 phosphodiesterase 1998998 yoaD 7065344 yoaD Escherichia coli O127:H6 str. E2348/69 phosphodiesterase YP_002329457.1 1997400 D 574521 CDS YP_002329458.1 215487027 7061206 complement(1999002..2000558) 1 NC_011601.1 fused membrane protein/conserved protein 2000558 yoaE 7061206 yoaE Escherichia coli O127:H6 str. E2348/69 fused membrane protein/conserved protein YP_002329458.1 1999002 R 574521 CDS YP_002329459.1 215487028 7061207 complement(2000546..2000755) 1 NC_011601.1 hypothetical protein 2000755 7061207 E2348C_1940 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329459.1 2000546 R 574521 CDS YP_002329460.1 215487029 7064524 2001021..2001992 1 NC_011601.1 fused mannose-specific PTS enzymes: IIA and IIB component 2001992 manX 7064524 manX Escherichia coli O127:H6 str. E2348/69 fused mannose-specific PTS enzymes: IIA and IIB component YP_002329460.1 2001021 D 574521 CDS YP_002329461.1 215487030 7065286 2002055..2002855 1 NC_011601.1 mannose-specific enzyme IIC component of PTS 2002855 manY 7065286 manY Escherichia coli O127:H6 str. E2348/69 mannose-specific enzyme IIC component of PTS YP_002329461.1 2002055 D 574521 CDS YP_002329462.1 215487031 7065287 2002859..2003719 1 NC_011601.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 2003719 manZ 7065287 manZ Escherichia coli O127:H6 str. E2348/69 PTS system mannose-specific transporter subunit IID YP_002329462.1 2002859 D 574521 CDS YP_002329463.1 215487032 7065288 2003774..2004232 1 NC_011601.1 hypothetical protein 2004232 yobD 7065288 yobD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329463.1 2003774 D 574521 CDS YP_002329464.1 215487033 7061147 2004661..2005227 1 NC_011601.1 membrane protein YebN; hypothetical protein 2005227 yebN 7061147 yebN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329464.1 2004661 D 574521 CDS YP_002329465.1 215487034 7064065 complement(2005224..2006033) 1 NC_011601.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase 2006033 rrmA 7064065 rrmA Escherichia coli O127:H6 str. E2348/69 23S rRNA methyltransferase YP_002329465.1 2005224 R 574521 CDS YP_002329466.1 215487035 7064540 complement(2006199..2006408) 1 NC_011601.1 cold shock-like protein CspC 2006408 cspC 7064540 cspC Escherichia coli O127:H6 str. E2348/69 cold shock-like protein CspC YP_002329466.1 2006199 R 574521 CDS YP_002329467.1 215487036 7062861 complement(2006421..2006564) 1 NC_011601.1 hypothetical protein 2006564 yobF 7062861 yobF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329467.1 2006421 R 574521 CDS YP_002329468.1 215487037 7061215 complement(2007235..2007522) 1 NC_011601.1 hypothetical protein 2007522 yebO 7061215 yebO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329468.1 2007235 R 574521 CDS YP_002329469.1 215487038 7064066 complement(2007597..2007740) 1 NC_011601.1 hypothetical protein 2007740 mgrB 7064066 mgrB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329469.1 2007597 R 574521 CDS YP_002329470.1 215487039 7063780 2007899..2008138 1 NC_011601.1 hypothetical protein 2008138 yobH 7063780 yobH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329470.1 2007899 D 574521 CDS YP_002329471.1 215487040 7061216 complement(2008282..2009073) 1 NC_011601.1 DNA-binding transcriptional regulator 2009073 kdgR 7061216 kdgR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329471.1 2008282 R 574521 CDS YP_002329472.1 215487041 7063570 2009250..2010623 1 NC_011601.1 transporter 2010623 yebQ 7063570 yebQ Escherichia coli O127:H6 str. E2348/69 transporter YP_002329472.1 2009250 D 574521 CDS YP_002329473.1 215487042 7064067 complement(2010669..2011550) 1 NC_011601.1 metalloprotease; heat shock protein HtpX 2011550 htpX 7064067 htpX Escherichia coli O127:H6 str. E2348/69 heat shock protein HtpX YP_002329473.1 2010669 R 574521 CDS YP_002329474.1 215487043 7062190 complement(2011742..2013790) 1 NC_011601.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 2013790 prc 7062190 prc Escherichia coli O127:H6 str. E2348/69 carboxy-terminal protease YP_002329474.1 2011742 R 574521 CDS YP_002329475.1 215487044 7061283 complement(2013810..2014508) 1 NC_011601.1 affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector 2014508 proQ 7061283 proQ Escherichia coli O127:H6 str. E2348/69 solute/DNA competence effector YP_002329475.1 2013810 R 574521 CDS YP_002329476.1 215487045 7061303 complement(2014605..2015156) 1 NC_011601.1 hypothetical protein 2015156 yebR 7061303 yebR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329476.1 2014605 R 574521 CDS YP_002329477.1 215487046 7062947 2015232..2016515 1 NC_011601.1 hypothetical protein 2016515 yebS 7062947 yebS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329477.1 2015232 D 574521 CDS YP_002329478.1 215487047 7063027 2016484..2019117 1 NC_011601.1 hypothetical protein 2019117 yebT 7063027 yebT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329478.1 2016484 D 574521 CDS YP_002329479.1 215487048 7063028 2019197..2020636 1 NC_011601.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 2020636 yebU 7063028 yebU Escherichia coli O127:H6 str. E2348/69 rRNA (cytosine-C(5)-)-methyltransferase RsmF YP_002329479.1 2019197 D 574521 CDS YP_002329480.1 215487049 7064559 2020754..2020990 1 NC_011601.1 hypothetical protein 2020990 yebV 7064559 yebV Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329480.1 2020754 D 574521 CDS YP_002329481.1 215487050 7063029 2021011..2021286 1 NC_011601.1 hypothetical protein 2021286 yebW 7063029 yebW Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329481.1 2021011 D 574521 CDS YP_002329482.1 215487051 7063030 complement(2021287..2021943) 1 NC_011601.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 2021943 pphA 7063030 pphA Escherichia coli O127:H6 str. E2348/69 serine/threonine protein phosphatase 1 YP_002329482.1 2021287 R 574521 CDS YP_002329483.1 215487052 7064596 complement(2022338..2022679) 1 NC_011601.1 hypothetical protein 2022679 yebY 7064596 yebY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329483.1 2022338 R 574521 CDS YP_002329484.1 215487053 7063031 complement(2022692..2023564) 1 NC_011601.1 hypothetical protein 2023564 yebZ 7063031 yebZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329484.1 2022692 R 574521 CDS YP_002329485.1 215487054 7063032 complement(2023568..2023942) 1 NC_011601.1 hypothetical protein 2023942 yobA 7063032 yobA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329485.1 2023568 R 574521 CDS YP_002329486.1 215487055 7061212 2024081..2024311 1 NC_011601.1 DNA polymerase III subunit theta 2024311 holE 7061212 holE Escherichia coli O127:H6 str. E2348/69 DNA polymerase III subunit theta YP_002329486.1 2024081 D 574521 CDS YP_002329487.1 215487056 7062175 2024413..2025069 1 NC_011601.1 hypothetical protein 2025069 yobB 7062175 yobB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329487.1 2024413 D 574521 CDS YP_002329488.1 215487057 7061213 2025093..2025755 1 NC_011601.1 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 2025755 exoX 7061213 exoX Escherichia coli O127:H6 str. E2348/69 exodeoxyribonuclease X YP_002329488.1 2025093 D 574521 CDS YP_002329489.1 215487058 7063907 complement(2025752..2027812) 1 NC_011601.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 2027812 ptrB 7063907 ptrB Escherichia coli O127:H6 str. E2348/69 protease 2 YP_002329489.1 2025752 R 574521 CDS YP_002329490.1 215487059 7061336 complement(2028019..2028678) 1 NC_011601.1 hypothetical protein 2028678 yebE 7061336 yebE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329490.1 2028019 R 574521 CDS YP_002329491.1 215487060 7064061 complement(2029005..2029361) 1 NC_011601.1 secreted protein; unknown function; hypothetical protein 2029361 yebF 7064061 yebF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329491.1 2029005 R 574521 CDS YP_002329492.1 215487061 7064062 complement(2029428..2029718) 1 NC_011601.1 DNA damage-inducible protein YebG 2029718 yebG 7064062 yebG Escherichia coli O127:H6 str. E2348/69 DNA damage-inducible protein YebG YP_002329492.1 2029428 R 574521 CDS YP_002329493.1 215487062 7064063 2029852..2031030 1 NC_011601.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 2031030 purT 7064063 purT Escherichia coli O127:H6 str. E2348/69 phosphoribosylglycinamide formyltransferase 2 YP_002329493.1 2029852 D 574521 CDS YP_002329494.1 215487063 7063923 complement(2031086..2031727) 1 NC_011601.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 2031727 eda 7063923 eda Escherichia coli O127:H6 str. E2348/69 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_002329494.1 2031086 R 574521 CDS YP_002329495.1 215487064 7063837 complement(2031764..2033575) 1 NC_011601.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 2033575 edd 7063837 edd Escherichia coli O127:H6 str. E2348/69 phosphogluconate dehydratase YP_002329495.1 2031764 R 574521 CDS YP_002329496.1 215487065 7063838 complement(2033810..2035285) 1 NC_011601.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 2035285 zwf 7063838 zwf Escherichia coli O127:H6 str. E2348/69 glucose-6-phosphate 1-dehydrogenase YP_002329496.1 2033810 R 574521 CDS YP_002329497.1 215487066 7062543 2035623..2036492 1 NC_011601.1 Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 2036492 yebK 7062543 yebK Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator HexR YP_002329497.1 2035623 D 574521 CDS YP_002329498.1 215487067 7064064 2036620..2038062 1 NC_011601.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2038062 pykA 7064064 pykA Escherichia coli O127:H6 str. E2348/69 pyruvate kinase YP_002329498.1 2036620 D 574521 CDS YP_002329499.1 215487068 7063927 complement(2038194..2039165) 1 NC_011601.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 2039165 lpxM 7063927 lpxM Escherichia coli O127:H6 str. E2348/69 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_002329499.1 2038194 R 574521 CDS YP_002329500.1 215487069 7061579 complement(2039284..2040606) 1 NC_011601.1 hypothetical protein 2040606 yebA 7061579 yebA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329500.1 2039284 R 574521 CDS YP_002329501.1 215487070 7064058 complement(2040622..2041554) 1 NC_011601.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic protein 2041554 znuA 7064058 znuA Escherichia coli O127:H6 str. E2348/69 high-affinity zinc transporter periplasmic protein YP_002329501.1 2040622 R 574521 CDS YP_002329502.1 215487071 7063262 2041633..2042388 1 NC_011601.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 2042388 znuC 7063262 znuC Escherichia coli O127:H6 str. E2348/69 high-affinity zinc transporter ATPase YP_002329502.1 2041633 D 574521 CDS YP_002329503.1 215487072 7061098 2042385..2043170 1 NC_011601.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane protein 2043170 znuB 7061098 znuB Escherichia coli O127:H6 str. E2348/69 high-affinity zinc transporter membrane protein YP_002329503.1 2042385 D 574521 CDS YP_002329504.1 215487073 7063263 complement(2043317..2044327) 1 NC_011601.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 2044327 ruvB 7063263 ruvB Escherichia coli O127:H6 str. E2348/69 Holliday junction DNA helicase RuvB YP_002329504.1 2043317 R 574521 CDS YP_002329505.1 215487074 7064589 complement(2044336..2044947) 1 NC_011601.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 2044947 ruvA 7064589 ruvA Escherichia coli O127:H6 str. E2348/69 Holliday junction DNA helicase RuvA YP_002329505.1 2044336 R 574521 CDS YP_002329506.1 215487075 7064588 2045223..2045825 1 NC_011601.1 hypothetical protein 2045825 yebB 7064588 yebB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329506.1 2045223 D 574521 CDS YP_002329507.1 215487076 7064059 complement(2045827..2046348) 1 NC_011601.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 2046348 ruvC 7064059 ruvC Escherichia coli O127:H6 str. E2348/69 Holliday junction resolvase YP_002329507.1 2045827 R 574521 CDS YP_002329508.1 215487077 7064590 complement(2046383..2047123) 1 NC_011601.1 hypothetical protein 2047123 yebC 7064590 yebC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329508.1 2046383 R 574521 CDS YP_002329509.1 215487078 7064060 complement(2047152..2047595) 1 NC_011601.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 2047595 ntpA 7064060 ntpA Escherichia coli O127:H6 str. E2348/69 dATP pyrophosphohydrolase YP_002329509.1 2047152 R 574521 CDS YP_002329510.1 215487079 7065427 complement(2047597..2049369) 1 NC_011601.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2049369 aspS 7065427 aspS Escherichia coli O127:H6 str. E2348/69 aspartyl-tRNA synthetase YP_002329510.1 2047597 R 574521 CDS YP_002329511.1 215487080 7062460 2049679..2050245 1 NC_011601.1 hypothetical protein 2050245 yecD 7062460 yecD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329511.1 2049679 D 574521 CDS YP_002329512.1 215487081 7063035 2050242..2051060 1 NC_011601.1 hypothetical protein 2051060 yecE 7063035 yecE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329512.1 2050242 D 574521 CDS YP_002329513.1 215487082 7063036 2051113..2051508 1 NC_011601.1 hypothetical protein 2051508 yecN 7063036 yecN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329513.1 2051113 D 574521 CDS YP_002329514.1 215487083 7063041 2051549..2052292 1 NC_011601.1 methyltransferase 2052292 cmoA 7063041 cmoA Escherichia coli O127:H6 str. E2348/69 methyltransferase YP_002329514.1 2051549 D 574521 CDS YP_002329515.1 215487084 7062815 2052289..2053260 1 NC_011601.1 S-adenosyl-L-methionine-dependent methyltransferase 2053260 cmoB 7062815 cmoB Escherichia coli O127:H6 str. E2348/69 S-adenosyl-L-methionine-dependent methyltransferase YP_002329515.1 2052289 D 574521 CDS YP_002329516.1 215487085 7062816 complement(2053425..2055854) 1 NC_011601.1 trimethylamine N-oxide reductase system III, catalytic subunit 2055854 torZ 7062816 torZ Escherichia coli O127:H6 str. E2348/69 trimethylamine N-oxide reductase system III, catalytic subunit YP_002329516.1 2053425 R 574521 CDS YP_002329517.1 215487086 7062228 complement(2055879..2056979) 1 NC_011601.1 TMAO reductase III (TorYZ), cytochrome c-type subunit 2056979 torY 7062228 torY Escherichia coli O127:H6 str. E2348/69 TMAO reductase III (TorYZ), cytochrome c-type subunit YP_002329517.1 2055879 R 574521 CDS YP_002329518.1 215487087 7062227 complement(2057367..2058113) 1 NC_011601.1 copper homeostasis protein CutC 2058113 cutC 7062227 cutC Escherichia coli O127:H6 str. E2348/69 copper homeostasis protein CutC YP_002329518.1 2057367 R 574521 CDS YP_002329519.1 215487088 7065176 complement(2058127..2058693) 1 NC_011601.1 hypothetical protein 2058693 yecM 7065176 yecM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329519.1 2058127 R 574521 CDS YP_002329520.1 215487089 7063040 2058909..2060642 1 NC_011601.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2060642 argS 7063040 argS Escherichia coli O127:H6 str. E2348/69 arginyl-tRNA synthetase YP_002329520.1 2058909 D 574521 CDS YP_002329521.1 215487090 7061377 complement(2060695..2061087) 1 NC_011601.1 hypothetical protein 2061087 flhE 7061377 flhE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329521.1 2060695 R 574521 CDS YP_002329522.1 215487091 7061912 complement(2061087..2063165) 1 NC_011601.1 membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 2063165 flhA 7061912 flhA Escherichia coli O127:H6 str. E2348/69 flagellar biosynthesis protein FlhA YP_002329522.1 2061087 R 574521 CDS YP_002329523.1 215487092 7061908 complement(2063158..2064306) 1 NC_011601.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 2064306 flhB 7061908 flhB Escherichia coli O127:H6 str. E2348/69 flagellar biosynthesis protein FlhB YP_002329523.1 2063158 R 574521 CDS YP_002329524.1 215487093 7061909 complement(2064495..2065139) 1 NC_011601.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ 2065139 cheZ 7061909 cheZ Escherichia coli O127:H6 str. E2348/69 chemotaxis regulator CheZ YP_002329524.1 2064495 R 574521 CDS YP_002329525.1 215487094 7064364 complement(2065150..2065539) 1 NC_011601.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 2065539 cheY 7064364 cheY Escherichia coli O127:H6 str. E2348/69 chemotaxis regulatory protein CheY YP_002329525.1 2065150 R 574521 CDS YP_002329526.1 215487095 7064363 complement(2065554..2066603) 1 NC_011601.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 2066603 cheB 7064363 cheB Escherichia coli O127:H6 str. E2348/69 chemotaxis-specific methylesterase YP_002329526.1 2065554 R 574521 CDS YP_002329527.1 215487096 7064360 complement(2066606..2067466) 1 NC_011601.1 methylates the MCP; chemotaxis methyltransferase CheR 2067466 cheR 7064360 cheR Escherichia coli O127:H6 str. E2348/69 chemotaxis methyltransferase CheR YP_002329527.1 2066606 R 574521 CDS YP_002329528.1 215487097 7064361 complement(2067757..2069418) 1 NC_011601.1 methyl-accepting chemotaxis protein II 2069418 tar 7064361 tar Escherichia coli O127:H6 str. E2348/69 methyl-accepting chemotaxis protein II YP_002329528.1 2067757 R 574521 CDS YP_002329529.1 215487098 7061148 complement(2069563..2070066) 1 NC_011601.1 purine-binding chemotaxis protein 2070066 cheW 7061148 cheW Escherichia coli O127:H6 str. E2348/69 purine-binding chemotaxis protein YP_002329529.1 2069563 R 574521 CDS YP_002329530.1 215487099 7064362 complement(2070087..2072051) 1 NC_011601.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 2072051 cheA 7064362 cheA Escherichia coli O127:H6 str. E2348/69 chemotaxis protein CheA YP_002329530.1 2070087 R 574521 CDS YP_002329531.1 215487100 7064359 complement(2072056..2072982) 1 NC_011601.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 2072982 motB 7064359 motB Escherichia coli O127:H6 str. E2348/69 flagellar motor protein MotB YP_002329531.1 2072056 R 574521 CDS YP_002329532.1 215487101 7063822 complement(2072979..2073866) 1 NC_011601.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 2073866 motA 7063822 motA Escherichia coli O127:H6 str. E2348/69 flagellar motor protein MotA YP_002329532.1 2072979 R 574521 CDS YP_002329533.1 215487102 7063821 complement(2073993..2074571) 1 NC_011601.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC 2074571 flhC 7063821 flhC Escherichia coli O127:H6 str. E2348/69 transcriptional activator FlhC YP_002329533.1 2073993 R 574521 CDS YP_002329534.1 215487103 7061910 complement(2074574..2074924) 1 NC_011601.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD 2074924 flhD 7061910 flhD Escherichia coli O127:H6 str. E2348/69 transcriptional activator FlhD YP_002329534.1 2074574 R 574521 CDS YP_002329535.1 215487104 7061911 2075704..2076132 1 NC_011601.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 2076132 uspC 7061911 uspC Escherichia coli O127:H6 str. E2348/69 universal stress protein UspC YP_002329535.1 2075704 D 574521 CDS YP_002329536.1 215487105 7062334 complement(2076139..2077563) 1 NC_011601.1 trehalose-6-phosphate synthase 2077563 otsA 7062334 otsA Escherichia coli O127:H6 str. E2348/69 trehalose-6-phosphate synthase YP_002329536.1 2076139 R 574521 CDS YP_002329537.1 215487106 7062894 complement(2077538..2078338) 1 NC_011601.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 2078338 otsB 7062894 otsB Escherichia coli O127:H6 str. E2348/69 trehalose-6-phosphate phosphatase YP_002329537.1 2077538 R 574521 CDS YP_002329538.1 215487107 7064229 complement(2078901..2080274) 1 NC_011601.1 transposase of ISEc13 2080274 7064229 E2348C_2020 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002329538.1 2078901 R 574521 CDS YP_002329539.1 215487108 7064525 complement(2081065..2082579) 1 NC_011601.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein 2082579 araG 7064525 araG Escherichia coli O127:H6 str. E2348/69 L-arabinose transporter ATP-binding protein YP_002329539.1 2081065 R 574521 CDS YP_002329540.1 215487109 7061361 complement(2082649..2083638) 1 NC_011601.1 L-arabinose transporter subunit 2083638 araF 7061361 araF Escherichia coli O127:H6 str. E2348/69 L-arabinose transporter subunit YP_002329540.1 2082649 R 574521 CDS YP_002329541.1 215487110 7061360 2084435..2084938 1 NC_011601.1 ferritin 2084938 ftnB 7061360 ftnB Escherichia coli O127:H6 str. E2348/69 ferritin YP_002329541.1 2084435 D 574521 CDS YP_002329542.1 215487111 7061580 complement(2085017..2085268) 1 NC_011601.1 hypothetical protein 2085268 yecJ 7061580 yecJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329542.1 2085017 R 574521 CDS YP_002329543.1 215487112 7063560 2085732..2086055 1 NC_011601.1 hypothetical protein 2086055 yecR 7063560 yecR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329543.1 2085732 D 574521 CDS YP_002329544.1 215487113 7063042 2086227..2086724 1 NC_011601.1 cytoplasmic iron storage protein; ferritin 2086724 ftnA 7063042 ftnA Escherichia coli O127:H6 str. E2348/69 ferritin YP_002329544.1 2086227 D 574521 CDS YP_002329545.1 215487114 7062058 complement(2086762..2087001) 1 NC_011601.1 hypothetical protein 2087001 yecH 7062058 yecH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329545.1 2086762 R 574521 CDS YP_002329546.1 215487115 7063038 2087192..2088403 1 NC_011601.1 tyrosine transporter 2088403 tyrP 7063038 tyrP Escherichia coli O127:H6 str. E2348/69 tyrosine transporter YP_002329546.1 2087192 D 574521 CDS YP_002329547.1 215487116 7062285 complement(2088465..2089130) 1 NC_011601.1 hypothetical protein 2089130 yecA 7062285 yecA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329547.1 2088465 R 574521 CDS YP_002329548.1 215487117 7061726 complement(2089779..2090327) 1 NC_011601.1 phosphatidylglycerophosphate synthetase 2090327 pgsA 7061726 pgsA Escherichia coli O127:H6 str. E2348/69 phosphatidylglycerophosphate synthetase YP_002329548.1 2089779 R 574521 CDS YP_002329549.1 215487118 7060719 complement(2090384..2092216) 1 NC_011601.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 2092216 uvrC 7060719 uvrC Escherichia coli O127:H6 str. E2348/69 excinuclease ABC subunit C YP_002329549.1 2090384 R 574521 CDS YP_002329550.1 215487119 7062342 complement(2092213..2092869) 1 NC_011601.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 2092869 uvrY 7062342 uvrY Escherichia coli O127:H6 str. E2348/69 response regulator YP_002329550.1 2092213 R 574521 CDS YP_002329551.1 215487120 7062344 2093328..2093552 1 NC_011601.1 hypothetical protein 2093552 yecF 7062344 yecF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329551.1 2093328 D 574521 CDS YP_002329552.1 215487121 7063037 complement(2093620..2094342) 1 NC_011601.1 regulates genes involved in cell division; DNA-binding transcriptional activator SdiA 2094342 sdiA 7063037 sdiA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator SdiA YP_002329552.1 2093620 R 574521 CDS YP_002329553.1 215487122 7065351 complement(2094572..2095324) 1 NC_011601.1 amino-acid ABC transporter ATP-binding protein YecC 2095324 yecC 7065351 yecC Escherichia coli O127:H6 str. E2348/69 amino-acid ABC transporter ATP-binding protein YecC YP_002329553.1 2094572 R 574521 CDS YP_002329554.1 215487123 7063034 complement(2095321..2095989) 1 NC_011601.1 transporter subunit: membrane component of ABC superfamily 2095989 yecS 7063034 yecS Escherichia coli O127:H6 str. E2348/69 transporter subunit: membrane component of ABC superfamily YP_002329554.1 2095321 R 574521 CDS YP_002329555.1 215487124 7063043 complement(2096004..2096990) 1 NC_011601.1 catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 2096990 dcyD 7063043 dcyD Escherichia coli O127:H6 str. E2348/69 D-cysteine desulfhydrase YP_002329555.1 2096004 R 574521 CDS YP_002329556.1 215487125 7065236 complement(2097095..2097895) 1 NC_011601.1 cystine transporter subunit 2097895 fliY 7065236 fliY Escherichia coli O127:H6 str. E2348/69 cystine transporter subunit YP_002329556.1 2097095 R 574521 CDS YP_002329557.1 215487126 7061932 complement(2097983..2098534) 1 NC_011601.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ 2098534 fliZ 7061932 fliZ Escherichia coli O127:H6 str. E2348/69 flagella biosynthesis protein FliZ YP_002329557.1 2097983 R 574521 CDS YP_002329558.1 215487127 7061933 complement(2098580..2099299) 1 NC_011601.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 2099299 fliA 7061933 fliA Escherichia coli O127:H6 str. E2348/69 flagellar biosynthesis sigma factor YP_002329558.1 2098580 R 574521 CDS YP_002329559.1 215487128 7061913 complement(2099620..2101266) 1 NC_011601.1 structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin 2101266 fliC 7061913 fliC Escherichia coli O127:H6 str. E2348/69 flagellin YP_002329559.1 2099620 R 574521 CDS YP_002329560.1 215487129 7061914 2101532..2102938 1 NC_011601.1 involved in flagellin assembly; flagellar capping protein 2102938 fliD 7061914 fliD Escherichia coli O127:H6 str. E2348/69 flagellar capping protein YP_002329560.1 2101532 D 574521 CDS YP_002329561.1 215487130 7061915 2102963..2103373 1 NC_011601.1 flagellin specific chaperone; flagellar protein FliS 2103373 fliS 7061915 fliS Escherichia coli O127:H6 str. E2348/69 flagellar protein FliS YP_002329561.1 2102963 D 574521 CDS YP_002329562.1 215487131 7061930 2103373..2103738 1 NC_011601.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2103738 fliT 7061930 fliT Escherichia coli O127:H6 str. E2348/69 flagellar biosynthesis protein FliT YP_002329562.1 2103373 D 574521 CDS YP_002329563.1 215487132 7061931 2103816..2105303 1 NC_011601.1 converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 2105303 amyA 7061931 amyA Escherichia coli O127:H6 str. E2348/69 alpha-amylase YP_002329563.1 2103816 D 574521 CDS YP_002329564.1 215487133 7063045 2105936..2107141 1 NC_011601.1 hypothetical protein 2107141 yedE 7063045 yedE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329564.1 2105936 D 574521 CDS YP_002329565.1 215487134 7063046 2107138..2107371 1 NC_011601.1 hypothetical protein 2107371 yedF 7063046 yedF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329565.1 2107138 D 574521 CDS YP_002329566.1 215487135 7063047 2107480..2108148 1 NC_011601.1 hypothetical protein 2108148 yedK 7063047 yedK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329566.1 2107480 D 574521 CDS YP_002329567.1 215487136 7063050 2108259..2108738 1 NC_011601.1 acyltransferase 2108738 yedL 7063050 yedL Escherichia coli O127:H6 str. E2348/69 acyltransferase YP_002329567.1 2108259 D 574521 CDS YP_002329568.1 215487137 7063051 complement(2109143..2109457) 1 NC_011601.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 2109457 fliE 7063051 fliE Escherichia coli O127:H6 str. E2348/69 flagellar hook-basal body protein FliE YP_002329568.1 2109143 R 574521 CDS YP_002329569.1 215487138 7061916 2109672..2111330 1 NC_011601.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 2111330 fliF 7061916 fliF Escherichia coli O127:H6 str. E2348/69 flagellar MS-ring protein YP_002329569.1 2109672 D 574521 CDS YP_002329570.1 215487139 7061917 2111323..2112318 1 NC_011601.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2112318 fliG 7061917 fliG Escherichia coli O127:H6 str. E2348/69 flagellar motor switch protein G YP_002329570.1 2111323 D 574521 CDS YP_002329571.1 215487140 7061918 2112311..2112997 1 NC_011601.1 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2112997 fliH 7061918 fliH Escherichia coli O127:H6 str. E2348/69 flagellar assembly protein H YP_002329571.1 2112311 D 574521 CDS YP_002329572.1 215487141 7061919 2112997..2114370 1 NC_011601.1 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2114370 fliI 7061919 fliI Escherichia coli O127:H6 str. E2348/69 flagellum-specific ATP synthase YP_002329572.1 2112997 D 574521 CDS YP_002329573.1 215487142 7061920 2114389..2114832 1 NC_011601.1 rod/hook and filament chaperone; flagellar biosynthesis chaperone 2114832 fliJ 7061920 fliJ Escherichia coli O127:H6 str. E2348/69 flagellar biosynthesis chaperone YP_002329573.1 2114389 D 574521 CDS YP_002329574.1 215487143 7061921 2114829..2115956 1 NC_011601.1 flagellar hook-length control protein 2115956 fliK 7061921 fliK Escherichia coli O127:H6 str. E2348/69 flagellar hook-length control protein YP_002329574.1 2114829 D 574521 CDS YP_002329575.1 215487144 7061922 2116061..2116525 1 NC_011601.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body protein FliL 2116525 fliL 7061922 fliL Escherichia coli O127:H6 str. E2348/69 flagellar basal body protein FliL YP_002329575.1 2116061 D 574521 CDS YP_002329576.1 215487145 7061923 2116530..2117534 1 NC_011601.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2117534 fliM 7061923 fliM Escherichia coli O127:H6 str. E2348/69 flagellar motor switch protein FliM YP_002329576.1 2116530 D 574521 CDS YP_002329577.1 215487146 7061924 2117531..2117944 1 NC_011601.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2117944 fliN 7061924 fliN Escherichia coli O127:H6 str. E2348/69 flagellar motor switch protein FliN YP_002329577.1 2117531 D 574521 CDS YP_002329578.1 215487147 7061925 2117947..2118312 1 NC_011601.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2118312 fliO 7061925 fliO Escherichia coli O127:H6 str. E2348/69 flagellar biosynthesis protein FliO YP_002329578.1 2117947 D 574521 CDS YP_002329579.1 215487148 7061926 2118312..2119049 1 NC_011601.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2119049 fliP 7061926 fliP Escherichia coli O127:H6 str. E2348/69 flagellar biosynthesis protein FliP YP_002329579.1 2118312 D 574521 CDS YP_002329580.1 215487149 7061927 2119059..2119328 1 NC_011601.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2119328 fliQ 7061927 fliQ Escherichia coli O127:H6 str. E2348/69 flagellar biosynthesis protein FliQ YP_002329580.1 2119059 D 574521 CDS YP_002329581.1 215487150 7061928 2119337..2120122 1 NC_011601.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2120122 fliR 7061928 fliR Escherichia coli O127:H6 str. E2348/69 flagellar biosynthesis protein FliR YP_002329581.1 2119337 D 574521 CDS YP_002329582.1 215487151 7061929 2120412..2121035 1 NC_011601.1 DNA-binding transcriptional activator, co-regulator with RcsB 2121035 rcsA 7061929 rcsA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator, co-regulator with RcsB YP_002329582.1 2120412 D 574521 CDS YP_002329583.1 215487152 7063963 complement(2121079..2121267) 1 NC_011601.1 hypothetical protein 2121267 dsrB 7063963 dsrB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329583.1 2121079 R 574521 CDS YP_002329584.1 215487153 7065069 2121430..2121657 1 NC_011601.1 hypothetical protein 2121657 yodD 7065069 yodD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329584.1 2121430 D 574521 CDS YP_002329585.1 215487154 7065068 2121955..2122770 1 NC_011601.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 2122770 yedP 7065068 yedP Escherichia coli O127:H6 str. E2348/69 mannosyl-3-phosphoglycerate phosphatase YP_002329585.1 2121955 D 574521 CDS YP_002329586.1 215487155 7063053 complement(2124631..2124813) 1 NC_011601.1 hypothetical protein 2124813 yodC 7063053 yodC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329586.1 2124631 R 574521 CDS YP_002329587.1 215487156 7061218 complement(2124892..2125809) 1 NC_011601.1 hypothetical protein 2125809 yedI 7061218 yedI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329587.1 2124892 R 574521 CDS YP_002329588.1 215487157 7063048 2125982..2126902 1 NC_011601.1 hypothetical protein 2126902 yedA 7063048 yedA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329588.1 2125982 D 574521 CDS YP_002329589.1 215487158 7063044 complement(2126891..2127361) 1 NC_011601.1 DNA mismatch endonuclease Vsr of very short patch repair 2127361 vsr 7063044 vsr Escherichia coli O127:H6 str. E2348/69 DNA mismatch endonuclease Vsr of very short patch repair YP_002329589.1 2126891 R 574521 CDS YP_002329590.1 215487159 7062363 complement(2127342..2128760) 1 NC_011601.1 DNA cytosine methylase 2128760 dcm 7062363 dcm Escherichia coli O127:H6 str. E2348/69 DNA cytosine methylase YP_002329590.1 2127342 R 574521 CDS YP_002329591.1 215487160 7065227 complement(2128827..2129522) 1 NC_011601.1 hypothetical protein 2129522 yedJ 7065227 yedJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329591.1 2128827 R 574521 CDS YP_002329592.1 215487161 7063049 complement(2129562..2129927) 1 NC_011601.1 hypothetical protein 2129927 yedR 7063049 yedR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329592.1 2129562 R 574521 CDS YP_002329593.1 215487162 7064553 2130493..2131551 1 NC_011601.1 hypothetical protein 2131551 ysdS 7064553 ysdS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329593.1 2130493 D 574521 CDS YP_002329594.1 215487163 7063237 2132145..2132996 1 NC_011601.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2132996 hchA 7063237 hchA Escherichia coli O127:H6 str. E2348/69 chaperone protein HchA YP_002329594.1 2132145 D 574521 CDS YP_002329595.1 215487164 7064281 complement(2133104..2134462) 1 NC_011601.1 sensory kinase in two-component regulatory system with YedW 2134462 yedV 7064281 yedV Escherichia coli O127:H6 str. E2348/69 sensory kinase in two-component regulatory system with YedW YP_002329595.1 2133104 R 574521 CDS YP_002329596.1 215487165 7063055 complement(2134462..2135133) 1 NC_011601.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 2135133 yedW 7063055 yedW Escherichia coli O127:H6 str. E2348/69 transcriptional regulatory protein YedW YP_002329596.1 2134462 R 574521 CDS YP_002329597.1 215487166 7063056 2135266..2135679 1 NC_011601.1 hypothetical protein 2135679 yedX 7063056 yedX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329597.1 2135266 D 574521 CDS YP_002329598.1 215487167 7063057 2135788..2136792 1 NC_011601.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 2136792 yedY 7063057 yedY Escherichia coli O127:H6 str. E2348/69 sulfite oxidase subunit YedY YP_002329598.1 2135788 D 574521 CDS YP_002329599.1 215487168 7063058 2136793..2137428 1 NC_011601.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2137428 yedZ 7063058 yedZ Escherichia coli O127:H6 str. E2348/69 sulfite oxidase subunit YedZ YP_002329599.1 2136793 D 574521 CDS YP_002329600.1 215487169 7063059 2137685..2138335 1 NC_011601.1 hypothetical protein 2138335 yodA 7063059 yodA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329600.1 2137685 D 574521 CDS YP_002329601.1 215487170 7065243 2139188..2139985 1 NC_011601.1 hypothetical protein 2139985 mtfA 7065243 mtfA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329601.1 2139188 D 574521 CDS YP_002329602.1 215487171 7063062 complement(2141521..2142573) 1 NC_011601.1 ADP-heptose: LPS heptosyltransferase 2142573 yeeL 7063062 yeeL Escherichia coli O127:H6 str. E2348/69 ADP-heptose: LPS heptosyltransferase YP_002329602.1 2141521 R 574521 CDS YP_002329603.1 215487172 7063063 2142888..2144204 1 NC_011601.1 shikimate transporter 2144204 shiA 7063063 shiA Escherichia coli O127:H6 str. E2348/69 shikimate transporter YP_002329603.1 2142888 D 574521 CDS YP_002329604.1 215487173 7062716 2144306..2145760 1 NC_011601.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2145760 amn 7062716 amn Escherichia coli O127:H6 str. E2348/69 AMP nucleosidase YP_002329604.1 2144306 D 574521 CDS YP_002329605.1 215487174 7062455 2146103..2146819 1 NC_011601.1 hypothetical protein 2146819 yeeN 7062455 yeeN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329605.1 2146103 D 574521 CDS YP_002329606.1 215487175 7064957 2147650..2148525 1 NC_011601.1 hypothetical protein 2148525 7064957 E2348C_2091 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329606.1 2147650 D 574521 CDS YP_002329607.1 215487176 7060940 2148976..2149266 1 NC_011601.1 hypothetical protein 2149266 7060940 E2348C_2093 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329607.1 2148976 D 574521 CDS YP_002329608.1 215487177 7060941 2149311..2149607 1 NC_011601.1 hypothetical protein 2149607 7060941 E2348C_2094 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329608.1 2149311 D 574521 CDS YP_002329609.1 215487178 7060942 2149681..2149923 1 NC_011601.1 H-NS-like DNA-binding protein 2149923 7060942 E2348C_2095 Escherichia coli O127:H6 str. E2348/69 H-NS-like DNA-binding protein YP_002329609.1 2149681 D 574521 CDS YP_002329610.1 215487179 7060943 2149973..2150215 1 NC_011601.1 hypothetical protein 2150215 7060943 E2348C_2096 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329610.1 2149973 D 574521 CDS YP_002329611.1 215487180 7060944 complement(2150446..2151123) 1 NC_011601.1 hypothetical protein 2151123 7060944 E2348C_2097 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329611.1 2150446 R 574521 CDS YP_002329612.1 215487181 7060945 complement(2151131..2151427) 1 NC_011601.1 hypothetical protein 2151427 7060945 E2348C_2098 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329612.1 2151131 R 574521 CDS YP_002329613.1 215487182 7060946 complement(2151455..2152189) 1 NC_011601.1 DNA-binding protein 2152189 7060946 E2348C_2099 Escherichia coli O127:H6 str. E2348/69 DNA-binding protein YP_002329613.1 2151455 R 574521 CDS YP_002329614.1 215487183 7060947 2153875..2154261 1 NC_011601.1 hypothetical protein 2154261 7060947 E2348C_2100 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329614.1 2153875 D 574521 CDS YP_002329615.1 215487184 7060948 2154506..2155528 1 NC_011601.1 hypothetical protein 2155528 7060948 E2348C_2101 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329615.1 2154506 D 574521 CDS YP_002329616.1 215487185 7060949 complement(2155613..2155990) 1 NC_011601.1 hypothetical protein 2155990 7060949 E2348C_2102 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329616.1 2155613 R 574521 CDS YP_002329617.1 215487186 7060950 complement(2156022..2156495) 1 NC_011601.1 hypothetical protein 2156495 7060950 E2348C_2103 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329617.1 2156022 R 574521 CDS YP_002329618.1 215487187 7060951 2156904..2157458 1 NC_011601.1 lipoprotein 2157458 7060951 E2348C_2104 Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002329618.1 2156904 D 574521 CDS YP_002329619.1 215487188 7060952 complement(2157558..2158490) 1 NC_011601.1 hypothetical protein 2158490 7060952 E2348C_2105 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329619.1 2157558 R 574521 CDS YP_002329620.1 215487189 7060953 complement(2158503..2160023) 1 NC_011601.1 hypothetical protein 2160023 7060953 E2348C_2106 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329620.1 2158503 R 574521 CDS YP_002329621.1 215487190 7060955 2162248..2162553 1 NC_011601.1 hypothetical protein 2162553 7060955 E2348C_2108 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329621.1 2162248 D 574521 CDS YP_002329622.1 215487191 7060956 2162951..2163508 1 NC_011601.1 type IV pilin-like protein 2163508 7060956 E2348C_2109 Escherichia coli O127:H6 str. E2348/69 type IV pilin-like protein YP_002329622.1 2162951 D 574521 CDS YP_002329623.1 215487192 7060957 2163561..2165024 1 NC_011601.1 hypothetical protein 2165024 7060957 E2348C_2110 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329623.1 2163561 D 574521 CDS YP_002329624.1 215487193 7060958 complement(2165139..2165483) 1 NC_011601.1 hypothetical protein 2165483 7060958 E2348C_2111 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329624.1 2165139 R 574521 CDS YP_002329625.1 215487194 7060959 complement(2165495..2166349) 1 NC_011601.1 hypothetical protein 2166349 7060959 E2348C_2112 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329625.1 2165495 R 574521 CDS YP_002329626.1 215487195 7060960 complement(2166339..2167244) 1 NC_011601.1 hypothetical protein 2167244 7060960 E2348C_2113 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329626.1 2166339 R 574521 CDS YP_002329627.1 215487196 7060961 2167611..2167862 1 NC_011601.1 hypothetical protein 2167862 7060961 E2348C_2114 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329627.1 2167611 D 574521 CDS YP_002329628.1 215487197 7060963 complement(2168237..2169472) 1 NC_011601.1 P4-family integrase 2169472 7060963 E2348C_2116 Escherichia coli O127:H6 str. E2348/69 P4-family integrase YP_002329628.1 2168237 R 574521 CDS YP_002329629.1 215487198 7060964 2169716..2170831 1 NC_011601.1 hypothetical protein 2170831 7060964 E2348C_2117 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329629.1 2169716 D 574521 CDS YP_002329630.1 215487199 7060965 2170831..2171547 1 NC_011601.1 hypothetical protein 2171547 7060965 E2348C_2118 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329630.1 2170831 D 574521 CDS YP_002329631.1 215487200 7060966 complement(2171614..2172882) 1 NC_011601.1 integrase 2172882 7060966 E2348C_2119 Escherichia coli O127:H6 str. E2348/69 integrase YP_002329631.1 2171614 R 574521 CDS YP_002329632.1 215487201 7061418 complement(2173238..2174878) 1 NC_011601.1 hypothetical protein 2174878 yeeO 7061418 yeeO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329632.1 2173238 R 574521 CDS YP_002329633.1 215487202 7061416 complement(2174999..2175949) 1 NC_011601.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 2175949 cbl 7061416 cbl Escherichia coli O127:H6 str. E2348/69 transcriptional regulator Cbl YP_002329633.1 2174999 R 574521 CDS YP_002329634.1 215487203 7064326 complement(2176051..2176968) 1 NC_011601.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 2176968 nac 7064326 nac Escherichia coli O127:H6 str. E2348/69 nitrogen assimilation transcriptional regulator YP_002329634.1 2176051 R 574521 CDS YP_002329635.1 215487204 7061417 complement(2177426..2178358) 1 NC_011601.1 hypothetical protein 2178358 erfK 7061417 erfK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329635.1 2177426 R 574521 CDS YP_002329636.1 215487205 7063866 complement(2178423..2179502) 1 NC_011601.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2179502 cobT 7063866 cobT Escherichia coli O127:H6 str. E2348/69 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_002329636.1 2178423 R 574521 CDS YP_002329637.1 215487206 7062827 complement(2179514..2180257) 1 NC_011601.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2180257 cobS 7062827 cobS Escherichia coli O127:H6 str. E2348/69 cobalamin synthase YP_002329637.1 2179514 R 574521 CDS YP_002329638.1 215487207 7062826 complement(2180254..2180799) 1 NC_011601.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase 2180799 cobU 7062826 cobU Escherichia coli O127:H6 str. E2348/69 adenosylcobinamide kinase YP_002329638.1 2180254 R 574521 CDS YP_002329639.1 215487208 7062828 complement(2180933..2181430) 1 NC_011601.1 hypothetical protein 2181430 7062828 E2348C_2127 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329639.1 2180933 R 574521 CDS YP_002329640.1 215487209 7061149 complement(2181855..2182772) 1 NC_011601.1 pdu/cob regulatory protein 2182772 pocR 7061149 pocR Escherichia coli O127:H6 str. E2348/69 pdu/cob regulatory protein YP_002329640.1 2181855 R 574521 CDS YP_002329641.1 215487210 7060767 complement(2182975..2183784) 1 NC_011601.1 propanediol diffusion facilitator 2183784 pduF 7060767 pduF Escherichia coli O127:H6 str. E2348/69 propanediol diffusion facilitator YP_002329641.1 2182975 R 574521 CDS YP_002329642.1 215487211 7062924 2184296..2184580 1 NC_011601.1 propanediol utilization protein PduA 2184580 pduA 7062924 pduA Escherichia coli O127:H6 str. E2348/69 propanediol utilization protein PduA YP_002329642.1 2184296 D 574521 CDS YP_002329643.1 215487212 7062919 2184577..2185389 1 NC_011601.1 propanediol utilization protein PduB 2185389 pduB 7062919 pduB Escherichia coli O127:H6 str. E2348/69 propanediol utilization protein PduB YP_002329643.1 2184577 D 574521 CDS YP_002329644.1 215487213 7062920 2185408..2187009 1 NC_011601.1 propanediol dehydratase, large subunit, AdoCbl-dependent 2187009 pduC 7062920 pduC Escherichia coli O127:H6 str. E2348/69 propanediol dehydratase, large subunit, AdoCbl-dependent YP_002329644.1 2185408 D 574521 CDS YP_002329645.1 215487214 7062921 2187082..2187750 1 NC_011601.1 propanediol dehydratase, medium subunit, AdoCbl-dependent 2187750 pduD 7062921 pduD Escherichia coli O127:H6 str. E2348/69 propanediol dehydratase, medium subunit, AdoCbl-dependent YP_002329645.1 2187082 D 574521 CDS YP_002329646.1 215487215 7062922 2187765..2188283 1 NC_011601.1 propanediol dehydratase, small subunit, AdoCbl-dependent 2188283 pduE 7062922 pduE Escherichia coli O127:H6 str. E2348/69 propanediol dehydratase, small subunit, AdoCbl-dependent YP_002329646.1 2187765 D 574521 CDS YP_002329647.1 215487216 7062923 2188293..2190125 1 NC_011601.1 propanediol dehydratase reactivation protein PduG 2190125 pduG 7062923 pduG Escherichia coli O127:H6 str. E2348/69 propanediol dehydratase reactivation protein PduG YP_002329647.1 2188293 D 574521 CDS YP_002329648.1 215487217 7062925 2190115..2190465 1 NC_011601.1 propanediol dehydratase reactivation protein PduH 2190465 pduH 7062925 pduH Escherichia coli O127:H6 str. E2348/69 propanediol dehydratase reactivation protein PduH YP_002329648.1 2190115 D 574521 CDS YP_002329649.1 215487218 7062926 2190485..2190760 1 NC_011601.1 propanediol utilization protein PduJ 2190760 pduJ 7062926 pduJ Escherichia coli O127:H6 str. E2348/69 propanediol utilization protein PduJ YP_002329649.1 2190485 D 574521 CDS YP_002329650.1 215487219 7062927 2190784..2191206 1 NC_011601.1 propanediol utilization protein PduK 2191206 pduK 7062927 pduK Escherichia coli O127:H6 str. E2348/69 propanediol utilization protein PduK YP_002329650.1 2190784 D 574521 CDS YP_002329651.1 215487220 7062928 2191209..2191841 1 NC_011601.1 propanediol utilization protein 2191841 pduL 7062928 pduL Escherichia coli O127:H6 str. E2348/69 propanediol utilization protein YP_002329651.1 2191209 D 574521 CDS YP_002329652.1 215487221 7062929 2191838..2192329 1 NC_011601.1 propanediol utilization protein 2192329 pduM 7062929 pduM Escherichia coli O127:H6 str. E2348/69 propanediol utilization protein YP_002329652.1 2191838 D 574521 CDS YP_002329653.1 215487222 7062930 2192333..2192608 1 NC_011601.1 propanediol utilization protein PduN 2192608 pduN 7062930 pduN Escherichia coli O127:H6 str. E2348/69 propanediol utilization protein PduN YP_002329653.1 2192333 D 574521 CDS YP_002329654.1 215487223 7062931 2192620..2193627 1 NC_011601.1 propanediol utilization protein PduO, AdoCbl-dependent 2193627 pduO 7062931 pduO Escherichia coli O127:H6 str. E2348/69 propanediol utilization protein PduO, AdoCbl-dependent YP_002329654.1 2192620 D 574521 CDS YP_002329655.1 215487224 7062932 2193624..2195009 1 NC_011601.1 CoA-dependent proprionaldehyde dehydrogenase 2195009 pduP 7062932 pduP Escherichia coli O127:H6 str. E2348/69 CoA-dependent proprionaldehyde dehydrogenase YP_002329655.1 2193624 D 574521 CDS YP_002329656.1 215487225 7062933 2195020..2196132 1 NC_011601.1 propanol dehydrogenase 2196132 pduQ 7062933 pduQ Escherichia coli O127:H6 str. E2348/69 propanol dehydrogenase YP_002329656.1 2195020 D 574521 CDS YP_002329657.1 215487226 7062934 2196129..2197472 1 NC_011601.1 propanediol utilization protein 2197472 pduS 7062934 pduS Escherichia coli O127:H6 str. E2348/69 propanediol utilization protein YP_002329657.1 2196129 D 574521 CDS YP_002329658.1 215487227 7062935 2197475..2198029 1 NC_011601.1 propanediol utilization protein PduT 2198029 pduT 7062935 pduT Escherichia coli O127:H6 str. E2348/69 propanediol utilization protein PduT YP_002329658.1 2197475 D 574521 CDS YP_002329659.1 215487228 7062936 2198029..2198379 1 NC_011601.1 propanediol utilization protein PduU 2198379 pduU 7062936 pduU Escherichia coli O127:H6 str. E2348/69 propanediol utilization protein PduU YP_002329659.1 2198029 D 574521 CDS YP_002329660.1 215487229 7062937 2198384..2198827 1 NC_011601.1 propanediol utilization protein 2198827 pduV 7062937 pduV Escherichia coli O127:H6 str. E2348/69 propanediol utilization protein YP_002329660.1 2198384 D 574521 CDS YP_002329661.1 215487230 7062938 complement(2198928..2199257) 1 NC_011601.1 hypothetical protein 2199257 yeeX 7062938 yeeX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329661.1 2198928 R 574521 CDS YP_002329662.1 215487231 7063066 complement(2199429..2200487) 1 NC_011601.1 hypothetical protein 2200487 yeeA 7063066 yeeA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329662.1 2199429 R 574521 CDS YP_002329663.1 215487232 7063060 complement(2200727..2201158) 1 NC_011601.1 DNA gyrase inhibitor 2201158 sbmC 7063060 sbmC Escherichia coli O127:H6 str. E2348/69 DNA gyrase inhibitor YP_002329663.1 2200727 R 574521 CDS YP_002329664.1 215487233 7065336 complement(2201277..2202443) 1 NC_011601.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 2202443 dacD 7065336 dacD Escherichia coli O127:H6 str. E2348/69 D-alanyl-D-alanine carboxypeptidase YP_002329664.1 2201277 R 574521 CDS YP_002329665.1 215487234 7065215 2202652..2204079 1 NC_011601.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2204079 sbcB 7065215 sbcB Escherichia coli O127:H6 str. E2348/69 exonuclease I YP_002329665.1 2202652 D 574521 CDS YP_002329666.1 215487235 7065332 complement(2204153..2205511) 1 NC_011601.1 amino-acid transporter 2205511 yeeF 7065332 yeeF Escherichia coli O127:H6 str. E2348/69 amino-acid transporter YP_002329666.1 2204153 R 574521 CDS YP_002329667.1 215487236 7063061 complement(2205778..2206707) 1 NC_011601.1 DNA-binding transcriptional regulator 2206707 yeeY 7063061 yeeY Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329667.1 2205778 R 574521 CDS YP_002329668.1 215487237 7063067 complement(2206753..2207577) 1 NC_011601.1 epimerase 2207577 yeeZ 7063067 yeeZ Escherichia coli O127:H6 str. E2348/69 epimerase YP_002329668.1 2206753 R 574521 CDS YP_002329669.1 215487238 7063068 complement(2207660..2207914) 1 NC_011601.1 toxin of the YoeB-YefM toxin-antitoxin system 2207914 yoeB 7063068 yoeB Escherichia coli O127:H6 str. E2348/69 toxin of the YoeB-YefM toxin-antitoxin system YP_002329669.1 2207660 R 574521 CDS YP_002329670.1 215487239 7061220 complement(2207911..2208162) 1 NC_011601.1 Antitoxin that counteracts the effect of the YoeB toxin; antitoxin YefM 2208162 yefM 7061220 yefM Escherichia coli O127:H6 str. E2348/69 antitoxin YefM YP_002329670.1 2207911 R 574521 CDS YP_002329672.1 215487241 7062152 2208641..2209540 1 NC_011601.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2209540 hisG 7062152 hisG Escherichia coli O127:H6 str. E2348/69 ATP phosphoribosyltransferase YP_002329672.1 2208641 D 574521 CDS YP_002329673.1 215487242 7062148 2209546..2210850 1 NC_011601.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2210850 hisD 7062148 hisD Escherichia coli O127:H6 str. E2348/69 histidinol dehydrogenase YP_002329673.1 2209546 D 574521 CDS YP_002329674.1 215487243 7062146 2210847..2211917 1 NC_011601.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2211917 hisC 7062146 hisC Escherichia coli O127:H6 str. E2348/69 histidinol-phosphate aminotransferase YP_002329674.1 2210847 D 574521 CDS YP_002329675.1 215487244 7062145 2211917..2212984 1 NC_011601.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2212984 hisB 7062145 hisB Escherichia coli O127:H6 str. E2348/69 imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_002329675.1 2211917 D 574521 CDS YP_002329676.1 215487245 7062144 2212984..2213574 1 NC_011601.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2213574 hisH 7062144 hisH Escherichia coli O127:H6 str. E2348/69 imidazole glycerol phosphate synthase subunit HisH YP_002329676.1 2212984 D 574521 CDS YP_002329677.1 215487246 7062149 2213574..2214311 1 NC_011601.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2214311 hisA 7062149 hisA Escherichia coli O127:H6 str. E2348/69 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_002329677.1 2213574 D 574521 CDS YP_002329678.1 215487247 7062143 2214293..2215069 1 NC_011601.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2215069 hisF 7062143 hisF Escherichia coli O127:H6 str. E2348/69 imidazole glycerol phosphate synthase subunit HisF YP_002329678.1 2214293 D 574521 CDS YP_002329679.1 215487248 7062147 2215063..2215674 1 NC_011601.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 2215674 hisI 7062147 hisI Escherichia coli O127:H6 str. E2348/69 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase YP_002329679.1 2215063 D 574521 CDS YP_002329680.1 215487249 7062150 complement(2215860..2216837) 1 NC_011601.1 regulator of length of O-antigen component of lipopolysaccharide chains 2216837 wzz 7062150 wzz Escherichia coli O127:H6 str. E2348/69 regulator of length of O-antigen component of lipopolysaccharide chains YP_002329680.1 2215860 R 574521 CDS YP_002329681.1 215487250 7064854 complement(2216984..2218150) 1 NC_011601.1 UDP-glucose 6-dehydrogenase 2218150 ugd 7064854 ugd Escherichia coli O127:H6 str. E2348/69 UDP-glucose 6-dehydrogenase YP_002329681.1 2216984 R 574521 CDS YP_002329682.1 215487251 7062302 complement(2218399..2219805) 1 NC_011601.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2219805 gnd 7062302 gnd Escherichia coli O127:H6 str. E2348/69 6-phosphogluconate dehydrogenase YP_002329682.1 2218399 R 574521 CDS YP_002329683.1 215487252 7061733 complement(2219926..2220825) 1 NC_011601.1 fucosyltransferase 2220825 wbiQ 7061733 wbiQ Escherichia coli O127:H6 str. E2348/69 fucosyltransferase YP_002329683.1 2219926 R 574521 CDS YP_002329684.1 215487253 7062368 complement(2220833..2221570) 1 NC_011601.1 glycosyl transferase family protein 2221570 wbiP 7062368 wbiP Escherichia coli O127:H6 str. E2348/69 glycosyl transferase family protein YP_002329684.1 2220833 R 574521 CDS YP_002329685.1 215487254 7062367 complement(2221571..2222737) 1 NC_011601.1 O-antigen polymerase 2222737 wzy 7062367 wzy Escherichia coli O127:H6 str. E2348/69 O-antigen polymerase YP_002329685.1 2221571 R 574521 CDS YP_002329686.1 215487255 7064852 complement(2222745..2223398) 1 NC_011601.1 O-acetyltransferase 2223398 wbiO 7064852 wbiO Escherichia coli O127:H6 str. E2348/69 O-acetyltransferase YP_002329686.1 2222745 R 574521 CDS YP_002329687.1 215487256 7062366 complement(2223395..2224666) 1 NC_011601.1 O-antigen flippase 2224666 wzx 7062366 wzx Escherichia coli O127:H6 str. E2348/69 O-antigen flippase YP_002329687.1 2223395 R 574521 CDS YP_002329688.1 215487257 7064849 complement(2224679..2226052) 1 NC_011601.1 phosphomannomutase 2226052 manB 7064849 manB Escherichia coli O127:H6 str. E2348/69 phosphomannomutase YP_002329688.1 2224679 R 574521 CDS YP_002329689.1 215487258 7065284 complement(2226056..2227504) 1 NC_011601.1 GDP-mannose pyrophosphorylase 2227504 manC 7065284 manC Escherichia coli O127:H6 str. E2348/69 GDP-mannose pyrophosphorylase YP_002329689.1 2226056 R 574521 CDS YP_002329690.1 215487259 7065285 complement(2227497..2227997) 1 NC_011601.1 GDP-mannose mannosyl hydrolase 2227997 7065285 E2348C_2178 Escherichia coli O127:H6 str. E2348/69 GDP-mannose mannosyl hydrolase YP_002329690.1 2227497 R 574521 CDS YP_002329691.1 215487260 7060969 complement(2228000..2228965) 1 NC_011601.1 bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase/GDP-4-dehydro-6-L-deoxygalactose reductase 2228965 7060969 E2348C_2179 Escherichia coli O127:H6 str. E2348/69 bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase/GDP-4-dehydro-6-L-deoxygalactose reductase YP_002329691.1 2228000 R 574521 CDS YP_002329692.1 215487261 7060970 complement(2228968..2230089) 1 NC_011601.1 GDP-D-mannose dehydratase 2230089 7060970 E2348C_2180 Escherichia coli O127:H6 str. E2348/69 GDP-D-mannose dehydratase YP_002329692.1 2228968 R 574521 CDS YP_002329693.1 215487262 7060971 complement(2230116..2231132) 1 NC_011601.1 glycosyl transferase family protein 2231132 wbiN 7060971 wbiN Escherichia coli O127:H6 str. E2348/69 glycosyl transferase family protein YP_002329693.1 2230116 R 574521 CDS YP_002329694.1 215487263 7062365 complement(2231151..2232170) 1 NC_011601.1 UDP-galactose-4-epimerase 2232170 galE 7062365 galE Escherichia coli O127:H6 str. E2348/69 UDP-galactose-4-epimerase YP_002329694.1 2231151 R 574521 CDS YP_002329695.1 215487264 7061616 complement(2232480..2233373) 1 NC_011601.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 2233373 galF 7061616 galF Escherichia coli O127:H6 str. E2348/69 UTP-glucose-1-phosphate uridylyltransferase YP_002329695.1 2232480 R 574521 CDS YP_002329696.1 215487265 7061617 complement(2233616..2234611) 1 NC_011601.1 UDP-galactose 4-epimerase 2234611 gne 7061617 gne Escherichia coli O127:H6 str. E2348/69 UDP-galactose 4-epimerase YP_002329696.1 2233616 R 574521 CDS YP_002329697.1 215487266 7061734 complement(2234769..2236163) 1 NC_011601.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; colanic acid biosynthesis protein 2236163 wcaM 7061734 wcaM Escherichia coli O127:H6 str. E2348/69 colanic acid biosynthesis protein YP_002329697.1 2234769 R 574521 CDS YP_002329698.1 215487267 7064843 complement(2236174..2237394) 1 NC_011601.1 glycosyl transferase family protein 2237394 wcaL 7064843 wcaL Escherichia coli O127:H6 str. E2348/69 glycosyl transferase family protein YP_002329698.1 2236174 R 574521 CDS YP_002329699.1 215487268 7062378 complement(2237391..2238671) 1 NC_011601.1 pyruvyl transferase 2238671 wcaK 7062378 wcaK Escherichia coli O127:H6 str. E2348/69 pyruvyl transferase YP_002329699.1 2237391 R 574521 CDS YP_002329700.1 215487269 7062377 complement(2238743..2240221) 1 NC_011601.1 colanic acid exporter 2240221 wzxC 7062377 wzxC Escherichia coli O127:H6 str. E2348/69 colanic acid exporter YP_002329700.1 2238743 R 574521 CDS YP_002329701.1 215487270 7064850 complement(2240223..2241617) 1 NC_011601.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; UDP-glucose lipid carrier transferase 2241617 wcaJ 7064850 wcaJ Escherichia coli O127:H6 str. E2348/69 UDP-glucose lipid carrier transferase YP_002329701.1 2240223 R 574521 CDS YP_002329702.1 215487271 7062376 complement(2241672..2243042) 1 NC_011601.1 phosphomannomutase 2243042 cpsG 7062376 cpsG Escherichia coli O127:H6 str. E2348/69 phosphomannomutase YP_002329702.1 2241672 R 574521 CDS YP_002329703.1 215487272 7062837 complement(2243235..2244671) 1 NC_011601.1 mannose-1-phosphate guanylyltransferase 2244671 cpsB 7062837 cpsB Escherichia coli O127:H6 str. E2348/69 mannose-1-phosphate guanylyltransferase YP_002329703.1 2243235 R 574521 CDS YP_002329704.1 215487273 7062836 complement(2244674..2245897) 1 NC_011601.1 glycosyl transferase family protein 2245897 wcaI 7062836 wcaI Escherichia coli O127:H6 str. E2348/69 glycosyl transferase family protein YP_002329704.1 2244674 R 574521 CDS YP_002329705.1 215487274 7062375 complement(2245894..2246373) 1 NC_011601.1 GDP-mannose mannosyl hydrolase 2246373 gmm 7062375 gmm Escherichia coli O127:H6 str. E2348/69 GDP-mannose mannosyl hydrolase YP_002329705.1 2245894 R 574521 CDS YP_002329706.1 215487275 7061732 complement(2246376..2247341) 1 NC_011601.1 bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase/GDP-4-dehydro-6-L-deoxygalactose reductase 2247341 fcl 7061732 fcl Escherichia coli O127:H6 str. E2348/69 bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase/GDP-4-dehydro-6-L-deoxygalactose reductase YP_002329706.1 2246376 R 574521 CDS YP_002329707.1 215487276 7062084 complement(2247344..2248465) 1 NC_011601.1 GDP-D-mannose dehydratase 2248465 gmd 7062084 gmd Escherichia coli O127:H6 str. E2348/69 GDP-D-mannose dehydratase YP_002329707.1 2247344 R 574521 CDS YP_002329708.1 215487277 7061729 complement(2248492..2249040) 1 NC_011601.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); colanic acid biosynthesis acetyltransferase WcaF 2249040 wcaF 7061729 wcaF Escherichia coli O127:H6 str. E2348/69 colanic acid biosynthesis acetyltransferase WcaF YP_002329708.1 2248492 R 574521 CDS YP_002329709.1 215487278 7062374 complement(2249056..2249802) 1 NC_011601.1 glycosyl transferase family protein 2249802 wcaE 7062374 wcaE Escherichia coli O127:H6 str. E2348/69 glycosyl transferase family protein YP_002329709.1 2249056 R 574521 CDS YP_002329710.1 215487279 7062373 complement(2249813..2251030) 1 NC_011601.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; colanic acid biosynthesis protein 2251030 wcaD 7062373 wcaD Escherichia coli O127:H6 str. E2348/69 colanic acid biosynthesis protein YP_002329710.1 2249813 R 574521 CDS YP_002329711.1 215487280 7062372 complement(2251005..2252222) 1 NC_011601.1 glycosyl transferase family protein 2252222 wcaC 7062372 wcaC Escherichia coli O127:H6 str. E2348/69 glycosyl transferase family protein YP_002329711.1 2251005 R 574521 CDS YP_002329712.1 215487281 7062371 complement(2252219..2252707) 1 NC_011601.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; colanic acid biosynthesis acetyltransferase WcaB 2252707 wcaB 7062371 wcaB Escherichia coli O127:H6 str. E2348/69 colanic acid biosynthesis acetyltransferase WcaB YP_002329712.1 2252219 R 574521 CDS YP_002329713.1 215487282 7062370 complement(2252710..2253549) 1 NC_011601.1 glycosyl transferase family protein 2253549 wcaA 7062370 wcaA Escherichia coli O127:H6 str. E2348/69 glycosyl transferase family protein YP_002329713.1 2252710 R 574521 CDS YP_002329714.1 215487283 7062369 complement(2253727..2255889) 1 NC_011601.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 2255889 wzc 7062369 wzc Escherichia coli O127:H6 str. E2348/69 tyrosine kinase YP_002329714.1 2253727 R 574521 CDS YP_002329715.1 215487284 7064848 complement(2255892..2256335) 1 NC_011601.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 2256335 wzb 7064848 wzb Escherichia coli O127:H6 str. E2348/69 tyrosine phosphatase YP_002329715.1 2255892 R 574521 CDS YP_002329716.1 215487285 7064847 complement(2256341..2257480) 1 NC_011601.1 lipoprotein required for capsular polysaccharide translocation through the outer membrane 2257480 wza 7064847 wza Escherichia coli O127:H6 str. E2348/69 lipoprotein required for capsular polysaccharide translocation through the outer membrane YP_002329716.1 2256341 R 574521 CDS YP_002329717.1 215487286 7064846 2258139..2259722 1 NC_011601.1 fused membrane protein/ membrane protein 2259722 yegH 7064846 yegH Escherichia coli O127:H6 str. E2348/69 fused membrane protein/ membrane protein YP_002329717.1 2258139 D 574521 CDS YP_002329718.1 215487287 7063071 complement(2260171..2262024) 1 NC_011601.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; assembly protein 2262024 asmA 7063071 asmA Escherichia coli O127:H6 str. E2348/69 assembly protein YP_002329718.1 2260171 R 574521 CDS YP_002329719.1 215487288 7061410 complement(2262046..2262627) 1 NC_011601.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 2262627 dcd 7061410 dcd Escherichia coli O127:H6 str. E2348/69 deoxycytidine triphosphate deaminase YP_002329719.1 2262046 R 574521 CDS YP_002329720.1 215487289 7065226 complement(2262719..2263360) 1 NC_011601.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 2263360 udk 7065226 udk Escherichia coli O127:H6 str. E2348/69 uridine kinase YP_002329720.1 2262719 R 574521 CDS YP_002329721.1 215487290 7061100 2264261..2265634 1 NC_011601.1 transposase of ISEc13 2265634 7061100 E2348C_2210 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002329721.1 2264261 D 574521 CDS YP_002329722.1 215487291 7060972 complement(2268663..2269511) 1 NC_011601.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyladenine DNA glycosylase 2269511 alkA 7060972 alkA Escherichia coli O127:H6 str. E2348/69 3-methyladenine DNA glycosylase YP_002329722.1 2268663 R 574521 CDS YP_002329723.1 215487292 7062437 2269645..2270997 1 NC_011601.1 chaperone 2270997 yegD 7062437 yegD Escherichia coli O127:H6 str. E2348/69 chaperone YP_002329723.1 2269645 D 574521 CDS YP_002329724.1 215487293 7063070 complement(2271010..2272950) 1 NC_011601.1 hypothetical protein 2272950 yegI 7063070 yegI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329724.1 2271010 R 574521 CDS YP_002329725.1 215487294 7063072 complement(2272947..2273708) 1 NC_011601.1 hypothetical protein 2273708 yegK 7063072 yegK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329725.1 2272947 R 574521 CDS YP_002329726.1 215487295 7063073 complement(2273705..2274364) 1 NC_011601.1 hypothetical protein 2274364 yegL 7063073 yegL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329726.1 2273705 R 574521 CDS YP_002329727.1 215487296 7061101 2274837..2276210 1 NC_011601.1 transposase of ISEc13 2276210 7061101 E2348C_2216 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002329727.1 2274837 D 574521 CDS YP_002329728.1 215487297 7060973 2276475..2277722 1 NC_011601.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2277722 mdtA 7060973 mdtA Escherichia coli O127:H6 str. E2348/69 multidrug efflux system subunit MdtA YP_002329728.1 2276475 D 574521 CDS YP_002329729.1 215487298 7065306 2277722..2280844 1 NC_011601.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2280844 mdtB 7065306 mdtB Escherichia coli O127:H6 str. E2348/69 multidrug efflux system subunit MdtB YP_002329729.1 2277722 D 574521 CDS YP_002329730.1 215487299 7065307 2280845..2283922 1 NC_011601.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2283922 mdtC 7065307 mdtC Escherichia coli O127:H6 str. E2348/69 multidrug efflux system subunit MdtC YP_002329730.1 2280845 D 574521 CDS YP_002329731.1 215487300 7065308 2283923..2285338 1 NC_011601.1 multidrug efflux system protein MdtE 2285338 mdtD 7065308 mdtD Escherichia coli O127:H6 str. E2348/69 multidrug efflux system protein MdtE YP_002329731.1 2283923 D 574521 CDS YP_002329732.1 215487301 7065309 2285335..2286738 1 NC_011601.1 signal transduction histidine-protein kinase BaeS 2286738 baeS 7065309 baeS Escherichia coli O127:H6 str. E2348/69 signal transduction histidine-protein kinase BaeS YP_002329732.1 2285335 D 574521 CDS YP_002329733.1 215487302 7062492 2286735..2287457 1 NC_011601.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2287457 baeR 7062492 baeR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator BaeR YP_002329733.1 2286735 D 574521 CDS YP_002329734.1 215487303 7062491 2287637..2287969 1 NC_011601.1 hypothetical protein 2287969 yegP 7062491 yegP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329734.1 2287637 D 574521 CDS YP_002329735.1 215487304 7063075 2288116..2289477 1 NC_011601.1 peptidase 2289477 yegQ 7063075 yegQ Escherichia coli O127:H6 str. E2348/69 peptidase YP_002329735.1 2288116 D 574521 CDS YP_002329736.1 215487305 7064597 complement(2289807..2290124) 1 NC_011601.1 hypothetical protein 2290124 yegR 7064597 yegR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329736.1 2289807 R 574521 CDS YP_002329737.1 215487306 7063077 2290539..2291438 1 NC_011601.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2291438 yegS 7063077 yegS Escherichia coli O127:H6 str. E2348/69 lipid kinase YP_002329737.1 2290539 D 574521 CDS YP_002329738.1 215487307 7063078 complement(2291519..2292160) 1 NC_011601.1 phosphatase 2292160 7063078 E2348C_2227 Escherichia coli O127:H6 str. E2348/69 phosphatase YP_002329738.1 2291519 R 574521 CDS YP_002329739.1 215487308 7060974 complement(2292205..2293482) 1 NC_011601.1 D-arabitol membrane transporter 2293482 atlT 7060974 atlT Escherichia coli O127:H6 str. E2348/69 D-arabitol membrane transporter YP_002329739.1 2292205 R 574521 CDS YP_002329740.1 215487309 7062472 complement(2293551..2295014) 1 NC_011601.1 D-xylulose kinase 2295014 atlK 7062472 atlK Escherichia coli O127:H6 str. E2348/69 D-xylulose kinase YP_002329740.1 2293551 R 574521 CDS YP_002329741.1 215487310 7062471 complement(2295028..2296395) 1 NC_011601.1 D-arabitol dehydrogenase 2296395 atlD 7062471 atlD Escherichia coli O127:H6 str. E2348/69 D-arabitol dehydrogenase YP_002329741.1 2295028 R 574521 CDS YP_002329742.1 215487311 7062470 2296603..2297544 1 NC_011601.1 D-arabitol repressor 2297544 altR 7062470 altR Escherichia coli O127:H6 str. E2348/69 D-arabitol repressor YP_002329742.1 2296603 D 574521 CDS YP_002329743.1 215487312 7064576 complement(2299901..2300680) 1 NC_011601.1 DNA-binding transcriptional repressor GatR 2300680 gatR 7064576 gatR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor GatR YP_002329743.1 2299901 R 574521 CDS YP_002329744.1 215487313 7061636 complement(2300780..2301820) 1 NC_011601.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase 2301820 gatD 7061636 gatD Escherichia coli O127:H6 str. E2348/69 galactitol-1-phosphate dehydrogenase YP_002329744.1 2300780 R 574521 CDS YP_002329745.1 215487314 7061635 complement(2301868..2303223) 1 NC_011601.1 PTS system galactitol-specific transporter subunit IIC 2303223 gatC 7061635 gatC Escherichia coli O127:H6 str. E2348/69 PTS system galactitol-specific transporter subunit IIC YP_002329745.1 2301868 R 574521 CDS YP_002329746.1 215487315 7061634 complement(2303227..2303511) 1 NC_011601.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB 2303511 gatB 7061634 gatB Escherichia coli O127:H6 str. E2348/69 PTS system galactitol-specific transporter subunit IIB YP_002329746.1 2303227 R 574521 CDS YP_002329747.1 215487316 7061633 complement(2303542..2303994) 1 NC_011601.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA 2303994 gatA 7061633 gatA Escherichia coli O127:H6 str. E2348/69 PTS system galactitol-specific transporter subunit IIA YP_002329747.1 2303542 R 574521 CDS YP_002329748.1 215487317 7061632 complement(2304004..2305266) 1 NC_011601.1 D-tagatose 1,6-bisphosphate aldolase 2, subunit 2305266 gatZ 7061632 gatZ Escherichia coli O127:H6 str. E2348/69 D-tagatose 1,6-bisphosphate aldolase 2, subunit YP_002329748.1 2304004 R 574521 CDS YP_002329749.1 215487318 7061638 complement(2305295..2306149) 1 NC_011601.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 2306149 gatY 7061638 gatY Escherichia coli O127:H6 str. E2348/69 tagatose-bisphosphate aldolase YP_002329749.1 2305295 R 574521 CDS YP_002329750.1 215487319 7061637 complement(2306376..2307428) 1 NC_011601.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 2307428 fbaB 7061637 fbaB Escherichia coli O127:H6 str. E2348/69 fructose-bisphosphate aldolase YP_002329750.1 2306376 R 574521 CDS YP_002329751.1 215487320 7062082 2307686..2308963 1 NC_011601.1 nucleoside transporter 2308963 yegT 7062082 yegT Escherichia coli O127:H6 str. E2348/69 nucleoside transporter YP_002329751.1 2307686 D 574521 CDS YP_002329752.1 215487321 7063079 2308960..2309964 1 NC_011601.1 hydrolase 2309964 yegU 7063079 yegU Escherichia coli O127:H6 str. E2348/69 hydrolase YP_002329752.1 2308960 D 574521 CDS YP_002329753.1 215487322 7063080 2309961..2310926 1 NC_011601.1 kinase 2310926 yegV 7063080 yegV Escherichia coli O127:H6 str. E2348/69 kinase YP_002329753.1 2309961 D 574521 CDS YP_002329754.1 215487323 7063081 complement(2310900..2311646) 1 NC_011601.1 DNA-binding transcriptional regulator 2311646 yegW 7063081 yegW Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329754.1 2310900 R 574521 CDS YP_002329755.1 215487324 7063082 complement(2311698..2312516) 1 NC_011601.1 hydrolase 2312516 yegX 7063082 yegX Escherichia coli O127:H6 str. E2348/69 hydrolase YP_002329755.1 2311698 R 574521 CDS YP_002329756.1 215487325 7063083 complement(2312581..2313381) 1 NC_011601.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 2313381 thiD 7063083 thiD Escherichia coli O127:H6 str. E2348/69 phosphomethylpyrimidine kinase YP_002329756.1 2312581 R 574521 CDS YP_002329757.1 215487326 7061781 complement(2313378..2314157) 1 NC_011601.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 2314157 thiM 7061781 thiM Escherichia coli O127:H6 str. E2348/69 hydroxyethylthiazole kinase YP_002329757.1 2313378 R 574521 CDS YP_002329758.1 215487327 7061150 complement(2314380..2314652) 1 NC_011601.1 hypothetical protein 2314652 rcnR 7061150 rcnR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329758.1 2314380 R 574521 CDS YP_002329759.1 215487328 7063962 2314773..2315603 1 NC_011601.1 membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2315603 rcnA 7063962 rcnA Escherichia coli O127:H6 str. E2348/69 nickel/cobalt efflux protein RcnA YP_002329759.1 2314773 D 574521 CDS YP_002329760.1 215487329 7063961 2315822..2316160 1 NC_011601.1 hypothetical protein 2316160 yohN 7063961 yohN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329760.1 2315822 D 574521 CDS YP_002329761.1 215487330 7061102 complement(2316194..2317567) 1 NC_011601.1 transposase of ISEc13 2317567 7061102 E2348C_2253 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002329761.1 2316194 R 574521 CDS YP_002329762.1 215487331 7060976 complement(2317801..2318835) 1 NC_011601.1 fimbrial protein-like protein 2318835 yehA 7060976 yehA Escherichia coli O127:H6 str. E2348/69 fimbrial protein-like protein YP_002329762.1 2317801 R 574521 CDS YP_002329763.1 215487332 7063084 complement(2318851..2321331) 1 NC_011601.1 outer membrane protein 2321331 yehB 7063084 yehB Escherichia coli O127:H6 str. E2348/69 outer membrane protein YP_002329763.1 2318851 R 574521 CDS YP_002329764.1 215487333 7063086 complement(2322103..2322645) 1 NC_011601.1 fimbrial protein-like protein 2322645 yehD 7063086 yehD Escherichia coli O127:H6 str. E2348/69 fimbrial protein-like protein YP_002329764.1 2322103 R 574521 CDS YP_002329765.1 215487334 7063087 complement(2322939..2323220) 1 NC_011601.1 hypothetical protein 2323220 yehE 7063087 yehE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329765.1 2322939 R 574521 CDS YP_002329766.1 215487335 7063088 complement(2323483..2324592) 1 NC_011601.1 ATPase 2324592 mrp 7063088 mrp Escherichia coli O127:H6 str. E2348/69 ATPase YP_002329766.1 2323483 R 574521 CDS YP_002329767.1 215487336 7060870 2324724..2326757 1 NC_011601.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2326757 metG 7060870 metG Escherichia coli O127:H6 str. E2348/69 methionyl-tRNA synthetase YP_002329767.1 2324724 D 574521 CDS YP_002329768.1 215487337 7063761 2326898..2330665 1 NC_011601.1 regulator 2330665 yehH 7063761 yehH Escherichia coli O127:H6 str. E2348/69 regulator YP_002329768.1 2326898 D 574521 CDS YP_002329769.1 215487338 7063089 2330704..2334330 1 NC_011601.1 hypothetical protein 2334330 yehI 7063089 yehI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329769.1 2330704 D 574521 CDS YP_002329771.1 215487340 7060977 2335409..2336497 1 NC_011601.1 transporter subunit: ATP-binding component of ABC superfamily 2336497 yehL 7060977 yehL Escherichia coli O127:H6 str. E2348/69 transporter subunit: ATP-binding component of ABC superfamily YP_002329771.1 2335409 D 574521 CDS YP_002329772.1 215487341 7063092 2336508..2338787 1 NC_011601.1 hypothetical protein 2338787 yehM 7063092 yehM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329772.1 2336508 D 574521 CDS YP_002329773.1 215487342 7063093 2338780..2339916 1 NC_011601.1 hypothetical protein 2339916 yehP 7063093 yehP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329773.1 2338780 D 574521 CDS YP_002329774.1 215487343 7063094 2339913..2341916 1 NC_011601.1 hypothetical protein 2341916 yehQ 7063094 yehQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329774.1 2339913 D 574521 CDS YP_002329775.1 215487344 7063095 2342041..2342502 1 NC_011601.1 hypothetical protein 2342502 yehR 7063095 yehR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329775.1 2342041 D 574521 CDS YP_002329776.1 215487345 7063096 complement(2342543..2343013) 1 NC_011601.1 hypothetical protein 2343013 yehS 7063096 yehS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329776.1 2342543 R 574521 CDS YP_002329777.1 215487346 7063097 complement(2343060..2343779) 1 NC_011601.1 unknown function; when overproduced it confers drug-resistance; two-component response-regulatory protein YehT 2343779 yehT 7063097 yehT Escherichia coli O127:H6 str. E2348/69 two-component response-regulatory protein YehT YP_002329777.1 2343060 R 574521 CDS YP_002329778.1 215487347 7063098 complement(2343776..2345461) 1 NC_011601.1 sensory kinase in two-component system with YehT 2345461 yehU 7063098 yehU Escherichia coli O127:H6 str. E2348/69 sensory kinase in two-component system with YehT YP_002329778.1 2343776 R 574521 CDS YP_002329779.1 215487348 7063099 2345683..2346414 1 NC_011601.1 DNA-binding transcriptional regulator 2346414 mlrA 7063099 mlrA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329779.1 2345683 D 574521 CDS YP_002329780.1 215487349 7063793 2346474..2346581 1 NC_011601.1 hypothetical protein 2346581 yohO 7063793 yohO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329780.1 2346474 D 574521 CDS YP_002329781.1 215487350 7061226 complement(2346562..2347293) 1 NC_011601.1 transporter subunit: membrane component of ABC superfamily 2347293 yehW 7061226 yehW Escherichia coli O127:H6 str. E2348/69 transporter subunit: membrane component of ABC superfamily YP_002329781.1 2346562 R 574521 CDS YP_002329782.1 215487351 7063100 complement(2347298..2348224) 1 NC_011601.1 transporter subunit: ATP-binding component of ABC superfamily 2348224 yehX 7063100 yehX Escherichia coli O127:H6 str. E2348/69 transporter subunit: ATP-binding component of ABC superfamily YP_002329782.1 2347298 R 574521 CDS YP_002329783.1 215487352 7063101 complement(2348217..2349374) 1 NC_011601.1 transporter subunit: membrane component of ABC superfamily 2349374 yehY 7063101 yehY Escherichia coli O127:H6 str. E2348/69 transporter subunit: membrane component of ABC superfamily YP_002329783.1 2348217 R 574521 CDS YP_002329784.1 215487353 7063102 complement(2349381..2350298) 1 NC_011601.1 transporter subunit: periplasmic-binding component of ABC superfamily 2350298 osmF 7063102 osmF Escherichia coli O127:H6 str. E2348/69 transporter subunit: periplasmic-binding component of ABC superfamily YP_002329784.1 2349381 R 574521 CDS YP_002329785.1 215487354 7062892 complement(2350488..2352785) 1 NC_011601.1 beta-D-glucoside glucohydrolase, periplasmic 2352785 bglX 7062892 bglX Escherichia coli O127:H6 str. E2348/69 beta-D-glucoside glucohydrolase, periplasmic YP_002329785.1 2350488 R 574521 CDS YP_002329786.1 215487355 7062518 2352981..2354696 1 NC_011601.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2354696 dld 7062518 dld Escherichia coli O127:H6 str. E2348/69 D-lactate dehydrogenase YP_002329786.1 2352981 D 574521 CDS YP_002329787.1 215487356 7065039 complement(2354735..2355667) 1 NC_011601.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 2355667 pbpG 7065039 pbpG Escherichia coli O127:H6 str. E2348/69 D-alanyl-D-alanine endopeptidase YP_002329787.1 2354735 R 574521 CDS YP_002329788.1 215487357 7062914 complement(2355841..2356428) 1 NC_011601.1 hypothetical protein 2356428 yohC 7062914 yohC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329788.1 2355841 R 574521 CDS YP_002329789.1 215487358 7061221 2356598..2357176 1 NC_011601.1 hypothetical protein 2357176 yohD 7061221 yohD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329789.1 2356598 D 574521 CDS YP_002329790.1 215487359 7061222 complement(2357296..2358057) 1 NC_011601.1 acetoin dehydrogenase 2358057 yohF 7061222 yohF Escherichia coli O127:H6 str. E2348/69 acetoin dehydrogenase YP_002329790.1 2357296 R 574521 CDS YP_002329791.1 215487360 7061223 complement(2358110..2359546) 1 NC_011601.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ 2359546 mdtQ 7061223 mdtQ Escherichia coli O127:H6 str. E2348/69 multidrug resistance outer membrane protein MdtQ YP_002329791.1 2358110 R 574521 CDS YP_002329792.1 215487361 7065321 complement(2360241..2361191) 1 NC_011601.1 tRNA-dihydrouridine synthase C 2361191 dusC 7065321 dusC Escherichia coli O127:H6 str. E2348/69 tRNA-dihydrouridine synthase C YP_002329792.1 2360241 R 574521 CDS YP_002329793.1 215487362 7065073 2361430..2361828 1 NC_011601.1 hypothetical protein 2361828 yohJ 7065073 yohJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329793.1 2361430 D 574521 CDS YP_002329794.1 215487363 7061224 2361825..2362520 1 NC_011601.1 hypothetical protein 2362520 yohK 7061224 yohK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329794.1 2361825 D 574521 CDS YP_002329795.1 215487364 7061225 2362650..2363534 1 NC_011601.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2363534 cdd 7061225 cdd Escherichia coli O127:H6 str. E2348/69 cytidine deaminase YP_002329795.1 2362650 D 574521 CDS YP_002329796.1 215487365 7064341 2363684..2364403 1 NC_011601.1 hypothetical protein 2364403 sanA 7064341 sanA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329796.1 2363684 D 574521 CDS YP_002329797.1 215487366 7065326 2364406..2364645 1 NC_011601.1 hypothetical protein 2364645 yeiS 7065326 yeiS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329797.1 2364406 D 574521 CDS YP_002329798.1 215487367 7063116 2364839..2366077 1 NC_011601.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; oxidoreductase 2366077 yeiT 7063116 yeiT Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002329798.1 2364839 D 574521 CDS YP_002329799.1 215487368 7063117 2366071..2367306 1 NC_011601.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2367306 yeiA 7063117 yeiA Escherichia coli O127:H6 str. E2348/69 dihydropyrimidine dehydrogenase YP_002329799.1 2366071 D 574521 CDS YP_002329800.1 215487369 7063103 complement(2367549..2368559) 1 NC_011601.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane protein 2368559 mglC 7063103 mglC Escherichia coli O127:H6 str. E2348/69 beta-methylgalactoside transporter inner membrane protein YP_002329800.1 2367549 R 574521 CDS YP_002329801.1 215487370 7063779 complement(2368575..2370095) 1 NC_011601.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 2370095 mglA 7063779 mglA Escherichia coli O127:H6 str. E2348/69 galactose/methyl galaxtoside transporter ATP-binding protein YP_002329801.1 2368575 R 574521 CDS YP_002329802.1 215487371 7063777 complement(2370156..2371154) 1 NC_011601.1 methyl-galactoside transporter subunit 2371154 mglB 7063777 mglB Escherichia coli O127:H6 str. E2348/69 methyl-galactoside transporter subunit YP_002329802.1 2370156 R 574521 CDS YP_002329803.1 215487372 7063778 complement(2371434..2372474) 1 NC_011601.1 negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 2372474 galS 7063778 galS Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator GalS YP_002329803.1 2371434 R 574521 CDS YP_002329804.1 215487373 7061622 complement(2372616..2373773) 1 NC_011601.1 hypothetical protein 2373773 yeiB 7061622 yeiB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329804.1 2372616 R 574521 CDS YP_002329805.1 215487374 7063104 complement(2373790..2374458) 1 NC_011601.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 2374458 folE 7063104 folE Escherichia coli O127:H6 str. E2348/69 GTP cyclohydrolase I YP_002329805.1 2373790 R 574521 CDS YP_002329806.1 215487375 7061942 2374716..2375552 1 NC_011601.1 esterase 2375552 yeiG 7061942 yeiG Escherichia coli O127:H6 str. E2348/69 esterase YP_002329806.1 2374716 D 574521 CDS YP_002329807.1 215487376 7063107 complement(2375584..2377575) 1 NC_011601.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor 2377575 cirA 7063107 cirA Escherichia coli O127:H6 str. E2348/69 colicin I receptor YP_002329807.1 2375584 R 574521 CDS YP_002329808.1 215487377 7062796 complement(2377867..2379336) 1 NC_011601.1 lysine transporter 2379336 lysP 7062796 lysP Escherichia coli O127:H6 str. E2348/69 lysine transporter YP_002329808.1 2377867 R 574521 CDS YP_002329809.1 215487378 7065252 complement(2379541..2380422) 1 NC_011601.1 DNA-binding transcriptional regulator 2380422 yeiE 7065252 yeiE Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329809.1 2379541 R 574521 CDS YP_002329810.1 215487379 7063106 2380521..2381570 1 NC_011601.1 hypothetical protein 2381570 yeiH 7063106 yeiH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329810.1 2380521 D 574521 CDS YP_002329811.1 215487380 7063108 2381644..2382501 1 NC_011601.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2382501 nfo 7063108 nfo Escherichia coli O127:H6 str. E2348/69 endonuclease IV YP_002329811.1 2381644 D 574521 CDS YP_002329812.1 215487381 7065382 2382505..2383593 1 NC_011601.1 hypothetical protein 2383593 yeiI 7065382 yeiI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329812.1 2382505 D 574521 CDS YP_002329813.1 215487382 7063109 complement(2383649..2384899) 1 NC_011601.1 nucleoside transporter 2384899 nupX 7063109 nupX Escherichia coli O127:H6 str. E2348/69 nucleoside transporter YP_002329813.1 2383649 R 574521 CDS YP_002329814.1 215487383 7062867 complement(2384999..2385940) 1 NC_011601.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 2385940 rihB 7062867 rihB Escherichia coli O127:H6 str. E2348/69 ribonucleoside hydrolase 2 YP_002329814.1 2384999 R 574521 CDS YP_002329815.1 215487384 7060825 2386109..2386768 1 NC_011601.1 activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2386768 yeiL 7060825 yeiL Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator YeiL YP_002329815.1 2386109 D 574521 CDS YP_002329816.1 215487385 7063110 complement(2386835..2388085) 1 NC_011601.1 nucleoside transporter 2388085 yeiM 7063110 yeiM Escherichia coli O127:H6 str. E2348/69 nucleoside transporter YP_002329816.1 2386835 R 574521 CDS YP_002329817.1 215487386 7063111 complement(2388179..2389117) 1 NC_011601.1 hypothetical protein 2389117 yeiN 7063111 yeiN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329817.1 2388179 R 574521 CDS YP_002329818.1 215487387 7063112 complement(2389105..2390046) 1 NC_011601.1 hypothetical protein 2390046 yeiC 7063112 yeiC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329818.1 2389105 R 574521 CDS YP_002329819.1 215487388 7063105 complement(2390502..2392193) 1 NC_011601.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunit IIBC 2392193 fruA 7063105 fruA Escherichia coli O127:H6 str. E2348/69 PTS system fructose-specific transporter subunit IIBC YP_002329819.1 2390502 R 574521 CDS YP_002329820.1 215487389 7061959 complement(2392210..2393148) 1 NC_011601.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 2393148 fruK 7061959 fruK Escherichia coli O127:H6 str. E2348/69 1-phosphofructokinase YP_002329820.1 2392210 R 574521 CDS YP_002329821.1 215487390 7061961 complement(2393148..2394278) 1 NC_011601.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein 2394278 fruB 7061961 fruB Escherichia coli O127:H6 str. E2348/69 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein YP_002329821.1 2393148 R 574521 CDS YP_002329822.1 215487391 7061960 2394645..2395826 1 NC_011601.1 lactose/glucose efflux system 2395826 setB 7061960 setB Escherichia coli O127:H6 str. E2348/69 lactose/glucose efflux system YP_002329822.1 2394645 D 574521 CDS YP_002329823.1 215487392 7062708 complement(2395823..2396077) 1 NC_011601.1 hypothetical protein 2396077 yeiW 7062708 yeiW Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329823.1 2395823 R 574521 CDS YP_002329824.1 215487393 7063119 2396232..2396804 1 NC_011601.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2396804 yeiP 7063119 yeiP Escherichia coli O127:H6 str. E2348/69 elongation factor P YP_002329824.1 2396232 D 574521 CDS YP_002329825.1 215487394 7063113 2397027..2398493 1 NC_011601.1 dehydrogenase, NAD-dependent 2398493 yeiQ 7063113 yeiQ Escherichia coli O127:H6 str. E2348/69 dehydrogenase, NAD-dependent YP_002329825.1 2397027 D 574521 CDS YP_002329826.1 215487395 7063114 2398611..2399597 1 NC_011601.1 hypothetical protein 2399597 yeiR 7063114 yeiR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329826.1 2398611 D 574521 CDS YP_002329827.1 215487396 7063115 2399636..2400349 1 NC_011601.1 undecaprenyl pyrophosphate phosphatase 2400349 yeiU 7063115 yeiU Escherichia coli O127:H6 str. E2348/69 undecaprenyl pyrophosphate phosphatase YP_002329827.1 2399636 D 574521 CDS YP_002329828.1 215487397 7063118 2400761..2401327 1 NC_011601.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance; outer membrane lipoprotein 2401327 spr 7063118 spr Escherichia coli O127:H6 str. E2348/69 outer membrane lipoprotein YP_002329828.1 2400761 D 574521 CDS YP_002329829.1 215487398 7062751 2401508..2403064 1 NC_011601.1 hypothetical protein 2403064 rtn 7062751 rtn Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329829.1 2401508 D 574521 CDS YP_002329830.1 215487399 7064577 2403146..2404960 1 NC_011601.1 oligopeptide transporter subunit 2404960 yejA 7064577 yejA Escherichia coli O127:H6 str. E2348/69 oligopeptide transporter subunit YP_002329830.1 2403146 D 574521 CDS YP_002329831.1 215487400 7063120 2404961..2406055 1 NC_011601.1 oligopeptide transporter subunit 2406055 yejB 7063120 yejB Escherichia coli O127:H6 str. E2348/69 oligopeptide transporter subunit YP_002329831.1 2404961 D 574521 CDS YP_002329832.1 215487401 7063121 2406055..2407080 1 NC_011601.1 oligopeptide transporter subunit 2407080 yejE 7063121 yejE Escherichia coli O127:H6 str. E2348/69 oligopeptide transporter subunit YP_002329832.1 2406055 D 574521 CDS YP_002329833.1 215487402 7063122 2407082..2408671 1 NC_011601.1 fused oligopeptide transporter subunits of ABC superfamilly: ATP-binding components 2408671 yejF 7063122 yejF Escherichia coli O127:H6 str. E2348/69 fused oligopeptide transporter subunits of ABC superfamilly: ATP-binding components YP_002329833.1 2407082 D 574521 CDS YP_002329834.1 215487403 7063123 complement(2408675..2409019) 1 NC_011601.1 hypothetical protein 2409019 yejG 7063123 yejG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329834.1 2408675 R 574521 CDS YP_002329835.1 215487404 7063124 complement(2409353..2410543) 1 NC_011601.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system protein 2410543 bcr 7063124 bcr Escherichia coli O127:H6 str. E2348/69 bicyclomycin/multidrug efflux system protein YP_002329835.1 2409353 R 574521 CDS YP_002329836.1 215487405 7062498 complement(2410571..2411266) 1 NC_011601.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 2411266 rsuA 7062498 rsuA Escherichia coli O127:H6 str. E2348/69 16S rRNA pseudouridylate synthase A YP_002329836.1 2410571 R 574521 CDS YP_002329837.1 215487406 7064566 2411416..2413176 1 NC_011601.1 ATP-dependet helicase 2413176 yejH 7064566 yejH Escherichia coli O127:H6 str. E2348/69 ATP-dependet helicase YP_002329837.1 2411416 D 574521 CDS YP_002329838.1 215487407 7063125 2413301..2413585 1 NC_011601.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2413585 rplY 7063125 rplY Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L25 YP_002329838.1 2413301 D 574521 CDS YP_002329839.1 215487408 7061852 complement(2413724..2414731) 1 NC_011601.1 nucleoid-associated protein NdpA 2414731 yejK 7061852 yejK Escherichia coli O127:H6 str. E2348/69 nucleoid-associated protein NdpA YP_002329839.1 2413724 R 574521 CDS YP_002329840.1 215487409 7063126 2414913..2415140 1 NC_011601.1 hypothetical protein 2415140 yejL 7063126 yejL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329840.1 2414913 D 574521 CDS YP_002329841.1 215487410 7063127 2415160..2416920 1 NC_011601.1 hydrolase, inner membrane 2416920 yejM 7063127 yejM Escherichia coli O127:H6 str. E2348/69 hydrolase, inner membrane YP_002329841.1 2415160 D 574521 CDS YP_002329842.1 215487411 7063129 2418446..2419093 1 NC_011601.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2419093 narP 7063129 narP Escherichia coli O127:H6 str. E2348/69 transcriptional regulator NarP YP_002329842.1 2418446 D 574521 CDS YP_002329843.1 215487412 7060937 complement(2419128..2420180) 1 NC_011601.1 heme lyase, CcmH subunit 2420180 ccmH 7060937 ccmH Escherichia coli O127:H6 str. E2348/69 heme lyase, CcmH subunit YP_002329843.1 2419128 R 574521 CDS YP_002329844.1 215487413 7064339 complement(2420177..2420734) 1 NC_011601.1 periplasmic thioredoxin CcmG of cytochrome c-type biogenesis 2420734 ccmG 7064339 ccmG Escherichia coli O127:H6 str. E2348/69 periplasmic thioredoxin CcmG of cytochrome c-type biogenesis YP_002329844.1 2420177 R 574521 CDS YP_002329845.1 215487414 7064338 complement(2420731..2422674) 1 NC_011601.1 heme lyase, CcmF subunit 2422674 ccmF 7064338 ccmF Escherichia coli O127:H6 str. E2348/69 heme lyase, CcmF subunit YP_002329845.1 2420731 R 574521 CDS YP_002329846.1 215487415 7064337 complement(2422671..2423150) 1 NC_011601.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 2423150 ccmE 7064337 ccmE Escherichia coli O127:H6 str. E2348/69 cytochrome c-type biogenesis protein CcmE YP_002329846.1 2422671 R 574521 CDS YP_002329847.1 215487416 7064336 complement(2423147..2423356) 1 NC_011601.1 cytochrome c biogenesis protein CcmD 2423356 ccmD 7064336 ccmD Escherichia coli O127:H6 str. E2348/69 cytochrome c biogenesis protein CcmD YP_002329847.1 2423147 R 574521 CDS YP_002329848.1 215487417 7064335 complement(2423353..2424090) 1 NC_011601.1 heme exporter protein C; membrane component of ABC superfamily 2424090 ccmC 7064335 ccmC Escherichia coli O127:H6 str. E2348/69 heme exporter protein C; membrane component of ABC superfamily YP_002329848.1 2423353 R 574521 CDS YP_002329849.1 215487418 7064334 complement(2424132..2424794) 1 NC_011601.1 heme exporter subunit 2424794 ccmB 7064334 ccmB Escherichia coli O127:H6 str. E2348/69 heme exporter subunit YP_002329849.1 2424132 R 574521 CDS YP_002329850.1 215487419 7064333 complement(2424791..2425408) 1 NC_011601.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 2425408 ccmA 7064333 ccmA Escherichia coli O127:H6 str. E2348/69 cytochrome c biogenesis protein CcmA YP_002329850.1 2424791 R 574521 CDS YP_002329851.1 215487420 7064332 complement(2425427..2426029) 1 NC_011601.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC 2426029 napC 7064332 napC Escherichia coli O127:H6 str. E2348/69 cytochrome c-type protein NapC YP_002329851.1 2425427 R 574521 CDS YP_002329852.1 215487421 7060926 complement(2426039..2426488) 1 NC_011601.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit 2426488 napB 7060926 napB Escherichia coli O127:H6 str. E2348/69 citrate reductase cytochrome c-type subunit YP_002329852.1 2426039 R 574521 CDS YP_002329853.1 215487422 7060925 complement(2426485..2427348) 1 NC_011601.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 2427348 napH 7060925 napH Escherichia coli O127:H6 str. E2348/69 quinol dehydrogenase membrane component YP_002329853.1 2426485 R 574521 CDS YP_002329854.1 215487423 7060930 complement(2427335..2428030) 1 NC_011601.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 2428030 napG 7060930 napG Escherichia coli O127:H6 str. E2348/69 quinol dehydrogenase periplasmic component YP_002329854.1 2427335 R 574521 CDS YP_002329855.1 215487424 7060929 complement(2428037..2430523) 1 NC_011601.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 2430523 napA 7060929 napA Escherichia coli O127:H6 str. E2348/69 nitrate reductase catalytic subunit YP_002329855.1 2428037 R 574521 CDS YP_002329856.1 215487425 7060924 complement(2430520..2430783) 1 NC_011601.1 assembly protein for periplasmic nitrate reductase 2430783 napD 7060924 napD Escherichia coli O127:H6 str. E2348/69 assembly protein for periplasmic nitrate reductase YP_002329856.1 2430520 R 574521 CDS YP_002329857.1 215487426 7060927 complement(2430773..2431267) 1 NC_011601.1 role in electron transfer to the periplasmic nitrate reductase NapA.; ferredoxin-type protein 2431267 napF 7060927 napF Escherichia coli O127:H6 str. E2348/69 ferredoxin-type protein YP_002329857.1 2430773 R 574521 CDS YP_002329858.1 215487427 7060928 2431376..2431540 1 NC_011601.1 hypothetical protein 2431540 yojO 7060928 yojO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329858.1 2431376 D 574521 CDS YP_002329859.1 215487428 7061228 2431675..2432163 1 NC_011601.1 serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2432163 eco 7061228 eco Escherichia coli O127:H6 str. E2348/69 ecotin YP_002329859.1 2431675 D 574521 CDS YP_002329860.1 215487429 7063829 complement(2432313..2433959) 1 NC_011601.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2433959 mqo 7063829 mqo Escherichia coli O127:H6 str. E2348/69 malate:quinone oxidoreductase YP_002329860.1 2432313 R 574521 CDS YP_002329861.1 215487430 7063828 complement(2434177..2435820) 1 NC_011601.1 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane protein/ATP-binding component 2435820 yojI 7063828 yojI Escherichia coli O127:H6 str. E2348/69 multidrug transporter membrane protein/ATP-binding component YP_002329861.1 2434177 R 574521 CDS YP_002329862.1 215487431 7061227 complement(2435896..2436546) 1 NC_011601.1 oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions 2436546 alkB 7061227 alkB Escherichia coli O127:H6 str. E2348/69 oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions YP_002329862.1 2435896 R 574521 CDS YP_002329863.1 215487432 7062438 complement(2436546..2437610) 1 NC_011601.1 fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase 2437610 ada 7062438 ada Escherichia coli O127:H6 str. E2348/69 fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase YP_002329863.1 2436546 R 574521 CDS YP_002329864.1 215487433 7062404 complement(2437684..2438739) 1 NC_011601.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 2438739 apbE 7062404 apbE Escherichia coli O127:H6 str. E2348/69 thiamine biosynthesis lipoprotein ApbE YP_002329864.1 2437684 R 574521 CDS YP_002329865.1 215487434 7061349 complement(2438851..2439966) 1 NC_011601.1 allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C 2439966 ompC 7061349 ompC Escherichia coli O127:H6 str. E2348/69 outer membrane porin protein C YP_002329865.1 2438851 R 574521 CDS YP_002329866.1 215487435 7063787 2440705..2443377 1 NC_011601.1 phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2443377 rcsD 7063787 rcsD Escherichia coli O127:H6 str. E2348/69 phosphotransfer intermediate protein in two-component regulatory system with RcsBC YP_002329866.1 2440705 D 574521 CDS YP_002329867.1 215487436 7063966 2443394..2444044 1 NC_011601.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2444044 rcsB 7063966 rcsB Escherichia coli O127:H6 str. E2348/69 transcriptional regulator RcsB YP_002329867.1 2443394 D 574521 CDS YP_002329868.1 215487437 7063964 complement(2444244..2447045) 1 NC_011601.1 hybrid sensory kinase in two-component regulatory system with RcsB and YojN 2447045 rcsC 7063964 rcsC Escherichia coli O127:H6 str. E2348/69 hybrid sensory kinase in two-component regulatory system with RcsB and YojN YP_002329868.1 2444244 R 574521 CDS YP_002329869.1 215487438 7063965 2447260..2449086 1 NC_011601.1 with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; sensory histidine kinase AtoS 2449086 atoS 7063965 atoS Escherichia coli O127:H6 str. E2348/69 sensory histidine kinase AtoS YP_002329869.1 2447260 D 574521 CDS YP_002329870.1 215487439 7062478 2449083..2450468 1 NC_011601.1 with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; acetoacetate metabolism regulatory protein AtoC 2450468 atoC 7062478 atoC Escherichia coli O127:H6 str. E2348/69 acetoacetate metabolism regulatory protein AtoC YP_002329870.1 2449083 D 574521 CDS YP_002329871.1 215487440 7062475 2450664..2451326 1 NC_011601.1 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 2451326 atoD 7062475 atoD Escherichia coli O127:H6 str. E2348/69 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha YP_002329871.1 2450664 D 574521 CDS YP_002329872.1 215487441 7062476 2451326..2451976 1 NC_011601.1 acetyl-CoA: acetoacetyl-CoA transferase, beta subunit 2451976 atoA 7062476 atoA Escherichia coli O127:H6 str. E2348/69 acetyl-CoA: acetoacetyl-CoA transferase, beta subunit YP_002329872.1 2451326 D 574521 CDS YP_002329873.1 215487442 7062473 2451973..2453295 1 NC_011601.1 short chain fatty acid transporter 2453295 atoE 7062473 atoE Escherichia coli O127:H6 str. E2348/69 short chain fatty acid transporter YP_002329873.1 2451973 D 574521 CDS YP_002329874.1 215487443 7062477 2453326..2454510 1 NC_011601.1 acetyl-CoA acetyltransferase 2454510 atoB 7062477 atoB Escherichia coli O127:H6 str. E2348/69 acetyl-CoA acetyltransferase YP_002329874.1 2453326 D 574521 CDS YP_002329875.1 215487444 7062474 complement(2454584..2455360) 1 NC_011601.1 hypothetical protein 2455360 yfaP 7062474 yfaP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329875.1 2454584 R 574521 CDS YP_002329876.1 215487445 7063134 complement(2455365..2457014) 1 NC_011601.1 hypothetical protein 2457014 yfaQ 7063134 yfaQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329876.1 2455365 R 574521 CDS YP_002329877.1 215487446 7063135 complement(2457015..2461622) 1 NC_011601.1 hypothetical protein 2461622 yfaS 7063135 yfaS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329877.1 2457015 R 574521 CDS YP_002329878.1 215487447 7063136 complement(2461556..2462179) 1 NC_011601.1 hypothetical protein 2462179 yfaT 7063136 yfaT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329878.1 2461556 R 574521 CDS YP_002329879.1 215487448 7063130 complement(2464012..2466639) 1 NC_011601.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 2466639 gyrA 7063130 gyrA Escherichia coli O127:H6 str. E2348/69 DNA gyrase subunit A YP_002329879.1 2464012 R 574521 CDS YP_002329880.1 215487449 7064278 2466786..2467508 1 NC_011601.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2467508 ubiG 7064278 ubiG Escherichia coli O127:H6 str. E2348/69 3-demethylubiquinone-9 3-methyltransferase YP_002329880.1 2466786 D 574521 CDS YP_002329881.1 215487450 7062296 complement(2467648..2471406) 1 NC_011601.1 adhesin 2471406 yfaL 7062296 yfaL Escherichia coli O127:H6 str. E2348/69 adhesin YP_002329881.1 2467648 R 574521 CDS YP_002329882.1 215487451 7063133 2472088..2474373 1 NC_011601.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2474373 nrdA 7063133 nrdA Escherichia coli O127:H6 str. E2348/69 ribonucleotide-diphosphate reductase subunit alpha YP_002329882.1 2472088 D 574521 CDS YP_002329883.1 215487452 7065409 2474563..2475693 1 NC_011601.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2475693 nrdB 7065409 nrdB Escherichia coli O127:H6 str. E2348/69 ribonucleotide-diphosphate reductase subunit beta YP_002329883.1 2474563 D 574521 CDS YP_002329884.1 215487453 7065410 2475693..2475947 1 NC_011601.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin 2475947 yfaE 7065410 yfaE Escherichia coli O127:H6 str. E2348/69 2Fe-2S ferredoxin YP_002329884.1 2475693 D 574521 CDS YP_002329885.1 215487454 7063132 complement(2476001..2476651) 1 NC_011601.1 hypothetical protein 2476651 inaA 7063132 inaA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329885.1 2476001 R 574521 CDS YP_002329886.1 215487455 7063541 complement(2476854..2477930) 1 NC_011601.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 2477930 glpQ 7063541 glpQ Escherichia coli O127:H6 str. E2348/69 glycerophosphodiester phosphodiesterase YP_002329886.1 2476854 R 574521 CDS YP_002329887.1 215487456 7061700 complement(2477935..2479293) 1 NC_011601.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter 2479293 glpT 7061700 glpT Escherichia coli O127:H6 str. E2348/69 sn-glycerol-3-phosphate transporter YP_002329887.1 2477935 R 574521 CDS YP_002329888.1 215487457 7061702 2479568..2481196 1 NC_011601.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2481196 glpA 7061702 glpA Escherichia coli O127:H6 str. E2348/69 sn-glycerol-3-phosphate dehydrogenase subunit A YP_002329888.1 2479568 D 574521 CDS YP_002329889.1 215487458 7061692 2481186..2482445 1 NC_011601.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2482445 glpB 7061692 glpB Escherichia coli O127:H6 str. E2348/69 anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_002329889.1 2481186 D 574521 CDS YP_002329890.1 215487459 7061693 2482442..2483632 1 NC_011601.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2483632 glpC 7061693 glpC Escherichia coli O127:H6 str. E2348/69 sn-glycerol-3-phosphate dehydrogenase subunit C YP_002329890.1 2482442 D 574521 CDS YP_002329891.1 215487460 7061694 2483825..2484772 1 NC_011601.1 hypothetical protein 2484772 yfaD 7061694 yfaD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329891.1 2483825 D 574521 CDS YP_002329892.1 215487461 7063131 2484785..2485006 1 NC_011601.1 hypothetical protein 2485006 ypaA 7063131 ypaA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329892.1 2484785 D 574521 CDS YP_002329893.1 215487462 7061229 complement(2485047..2485799) 1 NC_011601.1 aldolase 2485799 yfaU 7061229 yfaU Escherichia coli O127:H6 str. E2348/69 aldolase YP_002329893.1 2485047 R 574521 CDS YP_002329894.1 215487463 7063138 complement(2485868..2487157) 1 NC_011601.1 transporter 2487157 yfaV 7063138 yfaV Escherichia coli O127:H6 str. E2348/69 transporter YP_002329894.1 2485868 R 574521 CDS YP_002329895.1 215487464 7063139 complement(2487214..2488431) 1 NC_011601.1 enolase 2488431 yfaW 7063139 yfaW Escherichia coli O127:H6 str. E2348/69 enolase YP_002329895.1 2487214 R 574521 CDS YP_002329896.1 215487465 7063140 complement(2488434..2489216) 1 NC_011601.1 DNA-binding transcriptional regulator 2489216 yfaX 7063140 yfaX Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002329896.1 2488434 R 574521 CDS YP_002329897.1 215487466 7063141 complement(2489436..2490638) 1 NC_011601.1 competence damage-inducible protein A 2490638 yfaY 7063141 yfaY Escherichia coli O127:H6 str. E2348/69 competence damage-inducible protein A YP_002329897.1 2489436 R 574521 CDS YP_002329898.1 215487467 7063142 complement(2490738..2491280) 1 NC_011601.1 outer membrane porin protein 2491280 yfaZ 7063142 yfaZ Escherichia coli O127:H6 str. E2348/69 outer membrane porin protein YP_002329898.1 2490738 R 574521 CDS YP_002329899.1 215487468 7063143 2491559..2491984 1 NC_011601.1 NUDIX hydrolase 2491984 nudI 7063143 nudI Escherichia coli O127:H6 str. E2348/69 NUDIX hydrolase YP_002329899.1 2491559 D 574521 CDS YP_002329900.1 215487469 7065433 complement(2492023..2492625) 1 NC_011601.1 hypothetical protein 2492625 ais 7065433 ais Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329900.1 2492023 R 574521 CDS YP_002329901.1 215487470 7062428 2492915..2494072 1 NC_011601.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2494072 arnB 7062428 arnB Escherichia coli O127:H6 str. E2348/69 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase YP_002329901.1 2492915 D 574521 CDS YP_002329902.1 215487471 7061386 2494076..2495044 1 NC_011601.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2495044 arnC 7061386 arnC Escherichia coli O127:H6 str. E2348/69 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase YP_002329902.1 2494076 D 574521 CDS YP_002329903.1 215487472 7061387 2495044..2497026 1 NC_011601.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2497026 arnA 7061387 arnA Escherichia coli O127:H6 str. E2348/69 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase YP_002329903.1 2495044 D 574521 CDS YP_002329904.1 215487473 7061385 2497023..2497913 1 NC_011601.1 hypothetical protein 2497913 yfbH 7061385 yfbH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329904.1 2497023 D 574521 CDS YP_002329905.1 215487474 7063145 2497913..2499565 1 NC_011601.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2499565 arnT 7063145 arnT Escherichia coli O127:H6 str. E2348/69 4-amino-4-deoxy-L-arabinose transferase YP_002329905.1 2497913 D 574521 CDS YP_002329906.1 215487475 7061388 2499562..2499897 1 NC_011601.1 hypothetical protein 2499897 yfbW 7061388 yfbW Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329906.1 2499562 D 574521 CDS YP_002329907.1 215487476 7063155 2499897..2500283 1 NC_011601.1 hypothetical protein 2500283 yfbJ 7063155 yfbJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329907.1 2499897 D 574521 CDS YP_002329908.1 215487477 7063146 complement(2500277..2500549) 1 NC_011601.1 polymyxin resistance protein B 2500549 pmrD 7063146 pmrD Escherichia coli O127:H6 str. E2348/69 polymyxin resistance protein B YP_002329908.1 2500277 R 574521 CDS YP_002329909.1 215487478 7060760 complement(2500654..2502009) 1 NC_011601.1 O-succinylbenzoic acid--CoA ligase 2502009 menE 7060760 menE Escherichia coli O127:H6 str. E2348/69 O-succinylbenzoic acid--CoA ligase YP_002329909.1 2500654 R 574521 CDS YP_002329910.1 215487479 7063753 complement(2502006..2502968) 1 NC_011601.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2502968 menC 7063753 menC Escherichia coli O127:H6 str. E2348/69 O-succinylbenzoate synthase YP_002329910.1 2502006 R 574521 CDS YP_002329911.1 215487480 7063751 complement(2502968..2503825) 1 NC_011601.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 2503825 menB 7063751 menB Escherichia coli O127:H6 str. E2348/69 naphthoate synthase YP_002329911.1 2502968 R 574521 CDS YP_002329912.1 215487481 7063750 complement(2503840..2504598) 1 NC_011601.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase 2504598 yfbB 7063750 yfbB Escherichia coli O127:H6 str. E2348/69 acyl-CoA thioester hydrolase YP_002329912.1 2503840 R 574521 CDS YP_002329913.1 215487482 7063144 complement(2504595..2506265) 1 NC_011601.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2506265 menD 7063144 menD Escherichia coli O127:H6 str. E2348/69 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_002329913.1 2504595 R 574521 CDS YP_002329914.1 215487483 7063752 complement(2506354..2507649) 1 NC_011601.1 isochorismate synthase 2 2507649 menF 7063752 menF Escherichia coli O127:H6 str. E2348/69 isochorismate synthase 2 YP_002329914.1 2506354 R 574521 CDS YP_002329915.1 215487484 7063754 complement(2507728..2508033) 1 NC_011601.1 hypothetical protein 2508033 elaB 7063754 elaB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329915.1 2507728 R 574521 CDS YP_002329916.1 215487485 7063842 complement(2508088..2508549) 1 NC_011601.1 hypothetical protein 2508549 elaA 7063842 elaA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329916.1 2508088 R 574521 CDS YP_002329917.1 215487486 7063841 2508614..2509531 1 NC_011601.1 member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2509531 rbn 7063841 rbn Escherichia coli O127:H6 str. E2348/69 ribonuclease Z YP_002329917.1 2508614 D 574521 CDS YP_002329918.1 215487487 7063953 2509887..2510858 1 NC_011601.1 peptidase 2510858 yfbL 7063953 yfbL Escherichia coli O127:H6 str. E2348/69 peptidase YP_002329918.1 2509887 D 574521 CDS YP_002329919.1 215487488 7063147 2510961..2511464 1 NC_011601.1 hypothetical protein 2511464 yfbM 7063147 yfbM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329919.1 2510961 D 574521 CDS YP_002329920.1 215487489 7063148 complement(2511531..2512988) 1 NC_011601.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 2512988 nuoN 7063148 nuoN Escherichia coli O127:H6 str. E2348/69 NADH dehydrogenase subunit N YP_002329920.1 2511531 R 574521 CDS YP_002329921.1 215487490 7065449 complement(2512995..2514524) 1 NC_011601.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 2514524 nuoM 7065449 nuoM Escherichia coli O127:H6 str. E2348/69 NADH dehydrogenase subunit M YP_002329921.1 2512995 R 574521 CDS YP_002329922.1 215487491 7065448 complement(2514755..2516596) 1 NC_011601.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 2516596 nuoL 7065448 nuoL Escherichia coli O127:H6 str. E2348/69 NADH dehydrogenase subunit L YP_002329922.1 2514755 R 574521 CDS YP_002329923.1 215487492 7065447 complement(2516593..2516895) 1 NC_011601.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 2516895 nuoK 7065447 nuoK Escherichia coli O127:H6 str. E2348/69 NADH dehydrogenase subunit K YP_002329923.1 2516593 R 574521 CDS YP_002329924.1 215487493 7065446 complement(2516892..2517446) 1 NC_011601.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 2517446 nuoJ 7065446 nuoJ Escherichia coli O127:H6 str. E2348/69 NADH dehydrogenase subunit J YP_002329924.1 2516892 R 574521 CDS YP_002329925.1 215487494 7065445 complement(2517458..2518000) 1 NC_011601.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 2518000 nuoI 7065445 nuoI Escherichia coli O127:H6 str. E2348/69 NADH dehydrogenase subunit I YP_002329925.1 2517458 R 574521 CDS YP_002329926.1 215487495 7065444 complement(2518015..2518992) 1 NC_011601.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 2518992 nuoH 7065444 nuoH Escherichia coli O127:H6 str. E2348/69 NADH dehydrogenase subunit H YP_002329926.1 2518015 R 574521 CDS YP_002329927.1 215487496 7065443 complement(2518989..2521715) 1 NC_011601.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 2521715 nuoG 7065443 nuoG Escherichia coli O127:H6 str. E2348/69 NADH dehydrogenase subunit G YP_002329927.1 2518989 R 574521 CDS YP_002329928.1 215487497 7065442 complement(2521768..2523105) 1 NC_011601.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 2523105 nuoF 7065442 nuoF Escherichia coli O127:H6 str. E2348/69 NADH dehydrogenase I subunit F YP_002329928.1 2521768 R 574521 CDS YP_002329929.1 215487498 7065441 complement(2523102..2523602) 1 NC_011601.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 2523602 nuoE 7065441 nuoE Escherichia coli O127:H6 str. E2348/69 NADH dehydrogenase subunit E YP_002329929.1 2523102 R 574521 CDS YP_002329930.1 215487499 7065440 complement(2523605..2525407) 1 NC_011601.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D 2525407 nuoC 7065440 nuoC Escherichia coli O127:H6 str. E2348/69 bifunctional NADH:ubiquinone oxidoreductase subunit C/D YP_002329930.1 2523605 R 574521 CDS YP_002329931.1 215487500 7065439 complement(2525501..2526163) 1 NC_011601.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 2526163 nuoB 7065439 nuoB Escherichia coli O127:H6 str. E2348/69 NADH dehydrogenase subunit B YP_002329931.1 2525501 R 574521 CDS YP_002329932.1 215487501 7065438 complement(2526179..2526622) 1 NC_011601.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 2526622 nuoA 7065438 nuoA Escherichia coli O127:H6 str. E2348/69 NADH dehydrogenase subunit A YP_002329932.1 2526179 R 574521 CDS YP_002329933.1 215487502 7065437 complement(2527251..2528180) 1 NC_011601.1 DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes 2528180 lrhA 7065437 lrhA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes YP_002329933.1 2527251 R 574521 CDS YP_002329934.1 215487503 7065245 2529100..2530317 1 NC_011601.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 2530317 yfbQ 7065245 yfbQ Escherichia coli O127:H6 str. E2348/69 aminotransferase YP_002329934.1 2529100 D 574521 CDS YP_002329935.1 215487504 7063149 2530401..2531000 1 NC_011601.1 hypothetical protein 2531000 yfbR 7063149 yfbR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329935.1 2530401 D 574521 CDS YP_002329936.1 215487505 7063150 complement(2531059..2532891) 1 NC_011601.1 transporter 2532891 yfbS 7063150 yfbS Escherichia coli O127:H6 str. E2348/69 transporter YP_002329936.1 2531059 R 574521 CDS YP_002329937.1 215487506 7063151 complement(2532978..2533628) 1 NC_011601.1 phosphatase 2533628 yfbT 7063151 yfbT Escherichia coli O127:H6 str. E2348/69 phosphatase YP_002329937.1 2532978 R 574521 CDS YP_002329938.1 215487507 7063152 complement(2533639..2534133) 1 NC_011601.1 hypothetical protein 2534133 yfbU 7063152 yfbU Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329938.1 2533639 R 574521 CDS YP_002329939.1 215487508 7063153 complement(2534216..2534671) 1 NC_011601.1 hypothetical protein 2534671 yfbV 7063153 yfbV Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329939.1 2534216 R 574521 CDS YP_002329940.1 215487509 7063154 2535009..2536211 1 NC_011601.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2536211 ackA 7063154 ackA Escherichia coli O127:H6 str. E2348/69 acetate kinase YP_002329940.1 2535009 D 574521 CDS YP_002329941.1 215487510 7062389 2536286..2538430 1 NC_011601.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2538430 pta 7062389 pta Escherichia coli O127:H6 str. E2348/69 phosphate acetyltransferase YP_002329941.1 2536286 D 574521 CDS YP_002329942.1 215487511 7061333 2538620..2540140 1 NC_011601.1 hypothetical protein 2540140 yfcC 7061333 yfcC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329942.1 2538620 D 574521 CDS YP_002329943.1 215487512 7063157 complement(2540173..2540715) 1 NC_011601.1 NUDIX hydrolase 2540715 yfcD 7063157 yfcD Escherichia coli O127:H6 str. E2348/69 NUDIX hydrolase YP_002329943.1 2540173 R 574521 CDS YP_002329944.1 215487513 7063158 complement(2540773..2541324) 1 NC_011601.1 phosphodiesterase 2541324 yfcE 7063158 yfcE Escherichia coli O127:H6 str. E2348/69 phosphodiesterase YP_002329944.1 2540773 R 574521 CDS YP_002329945.1 215487514 7063159 complement(2541380..2542024) 1 NC_011601.1 hypothetical protein 2542024 yfcF 7063159 yfcF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329945.1 2541380 R 574521 CDS YP_002329946.1 215487515 7063160 2542160..2542807 1 NC_011601.1 glutathione S-transferase 2542807 yfcG 7063160 yfcG Escherichia coli O127:H6 str. E2348/69 glutathione S-transferase YP_002329946.1 2542160 D 574521 CDS YP_002329947.1 215487516 7063161 2542864..2543226 1 NC_011601.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2543226 folX 7063161 folX Escherichia coli O127:H6 str. E2348/69 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase YP_002329947.1 2542864 D 574521 CDS YP_002329948.1 215487517 7061946 2543247..2544140 1 NC_011601.1 hypothetical protein 2544140 yfcH 7061946 yfcH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329948.1 2543247 D 574521 CDS YP_002329949.1 215487518 7063162 complement(2544188..2545090) 1 NC_011601.1 hypothetical protein 2545090 yfcI 7063162 yfcI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329949.1 2544188 R 574521 CDS YP_002329950.1 215487519 7063163 complement(2545286..2546059) 1 NC_011601.1 histidine/lysine/arginine/ornithine transporter subunit 2546059 hisP 7063163 hisP Escherichia coli O127:H6 str. E2348/69 histidine/lysine/arginine/ornithine transporter subunit YP_002329950.1 2545286 R 574521 CDS YP_002329951.1 215487520 7062154 complement(2546067..2546783) 1 NC_011601.1 histidine/lysine/arginine/ornithine transporter subunit 2546783 hisM 7062154 hisM Escherichia coli O127:H6 str. E2348/69 histidine/lysine/arginine/ornithine transporter subunit YP_002329951.1 2546067 R 574521 CDS YP_002329952.1 215487521 7062153 complement(2546780..2547466) 1 NC_011601.1 histidine/lysine/arginine/ornithine transporter subunit HisQ, membrane component of ABC superfamily 2547466 hisQ 7062153 hisQ Escherichia coli O127:H6 str. E2348/69 histidine/lysine/arginine/ornithine transporter subunit HisQ, membrane component of ABC superfamily YP_002329952.1 2546780 R 574521 CDS YP_002329953.1 215487522 7062155 complement(2547556..2548338) 1 NC_011601.1 histidine/lysine/arginine/ornithine transporter subunit 2548338 hisJ 7062155 hisJ Escherichia coli O127:H6 str. E2348/69 histidine/lysine/arginine/ornithine transporter subunit YP_002329953.1 2547556 R 574521 CDS YP_002329954.1 215487523 7062151 complement(2548559..2549341) 1 NC_011601.1 lysine/arginine/ornithine transporter subunit 2549341 argT 7062151 argT Escherichia coli O127:H6 str. E2348/69 lysine/arginine/ornithine transporter subunit YP_002329954.1 2548559 R 574521 CDS YP_002329955.1 215487524 7061378 complement(2549607..2550176) 1 NC_011601.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2550176 ubiX 7061378 ubiX Escherichia coli O127:H6 str. E2348/69 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_002329955.1 2549607 R 574521 CDS YP_002329956.1 215487525 7062298 complement(2550271..2551788) 1 NC_011601.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 2551788 purF 7062298 purF Escherichia coli O127:H6 str. E2348/69 amidophosphoribosyltransferase YP_002329956.1 2550271 R 574521 CDS YP_002329957.1 215487526 7063916 complement(2551825..2552313) 1 NC_011601.1 membrane protein required for colicin V production; colicin V production protein 2552313 cvpA 7063916 cvpA Escherichia coli O127:H6 str. E2348/69 colicin V production protein YP_002329957.1 2551825 R 574521 CDS YP_002329958.1 215487527 7065177 complement(2552643..2553305) 1 NC_011601.1 hypothetical protein 2553305 dedD 7065177 dedD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329958.1 2552643 R 574521 CDS YP_002329959.1 215487528 7065241 complement(2553295..2554563) 1 NC_011601.1 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 2554563 folC 7065241 folC Escherichia coli O127:H6 str. E2348/69 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase YP_002329959.1 2553295 R 574521 CDS YP_002329960.1 215487529 7061940 complement(2554633..2555547) 1 NC_011601.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 2555547 accD 7061940 accD Escherichia coli O127:H6 str. E2348/69 acetyl-CoA carboxylase subunit beta YP_002329960.1 2554633 R 574521 CDS YP_002329961.1 215487530 7062383 complement(2555703..2556362) 1 NC_011601.1 hypothetical protein 2556362 dedA 7062383 dedA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329961.1 2555703 R 574521 CDS YP_002329962.1 215487531 7065240 complement(2556445..2557257) 1 NC_011601.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2557257 truA 7065240 truA Escherichia coli O127:H6 str. E2348/69 tRNA pseudouridine synthase A YP_002329962.1 2556445 R 574521 CDS YP_002329963.1 215487532 7062263 complement(2557257..2558270) 1 NC_011601.1 semialdehyde dehydrogenase 2558270 usg 7062263 usg Escherichia coli O127:H6 str. E2348/69 semialdehyde dehydrogenase YP_002329963.1 2557257 R 574521 CDS YP_002329964.1 215487533 7062330 complement(2558336..2559472) 1 NC_011601.1 erythronate-4-phosphate dehydrogenase 2559472 pdxB 7062330 pdxB Escherichia coli O127:H6 str. E2348/69 erythronate-4-phosphate dehydrogenase YP_002329964.1 2558336 R 574521 CDS YP_002329965.1 215487534 7062940 2559571..2560566 1 NC_011601.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2560566 flk 7062940 flk Escherichia coli O127:H6 str. E2348/69 flagella biosynthesis regulator YP_002329965.1 2559571 D 574521 CDS YP_002329966.1 215487535 7061934 complement(2560563..2561741) 1 NC_011601.1 hypothetical protein 2561741 yfcJ 7061934 yfcJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329966.1 2560563 R 574521 CDS YP_002329967.1 215487536 7063164 complement(2562006..2563226) 1 NC_011601.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 2563226 fabB 7063164 fabB Escherichia coli O127:H6 str. E2348/69 3-oxoacyl-ACP synthase YP_002329967.1 2562006 R 574521 CDS YP_002329968.1 215487537 7062063 2563385..2565391 1 NC_011601.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2565391 mnmC 7062063 mnmC Escherichia coli O127:H6 str. E2348/69 5-methylaminomethyl-2-thiouridine methyltransferase YP_002329968.1 2563385 D 574521 CDS YP_002329969.1 215487538 7063800 complement(2565512..2565790) 1 NC_011601.1 hypothetical protein 2565790 yfcL 7063800 yfcL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329969.1 2565512 R 574521 CDS YP_002329970.1 215487539 7063165 complement(2565824..2566372) 1 NC_011601.1 hypothetical protein 2566372 yfcM 7063165 yfcM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329970.1 2565824 R 574521 CDS YP_002329971.1 215487540 7063166 complement(2566372..2567181) 1 NC_011601.1 hypothetical protein 2567181 yfcA 7063166 yfcA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329971.1 2566372 R 574521 CDS YP_002329972.1 215487541 7063156 complement(2567181..2568005) 1 NC_011601.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 2568005 mepA 7063156 mepA Escherichia coli O127:H6 str. E2348/69 penicillin-insensitive murein endopeptidase YP_002329972.1 2567181 R 574521 CDS YP_002329973.1 215487542 7063755 complement(2568009..2569094) 1 NC_011601.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2569094 aroC 7063755 aroC Escherichia coli O127:H6 str. E2348/69 chorismate synthase YP_002329973.1 2568009 R 574521 CDS YP_002329974.1 215487543 7061391 complement(2569129..2570061) 1 NC_011601.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 2570061 prmB 7061391 prmB Escherichia coli O127:H6 str. E2348/69 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_002329974.1 2569129 R 574521 CDS YP_002329975.1 215487544 7061294 2570227..2570778 1 NC_011601.1 hypothetical protein 2570778 yfcN 7061294 yfcN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329975.1 2570227 D 574521 CDS YP_002329976.1 215487545 7063167 complement(2570848..2571711) 1 NC_011601.1 hypothetical protein 2571711 yfcO 7063167 yfcO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329976.1 2570848 R 574521 CDS YP_002329977.1 215487546 7063168 complement(2571713..2572258) 1 NC_011601.1 fimbrial subunit protein 2572258 yfcP 7063168 yfcP Escherichia coli O127:H6 str. E2348/69 fimbrial subunit protein YP_002329977.1 2571713 R 574521 CDS YP_002329978.1 215487547 7063169 complement(2572255..2572734) 1 NC_011601.1 fimbrial subunit protein 2572734 yfcQ 7063169 yfcQ Escherichia coli O127:H6 str. E2348/69 fimbrial subunit protein YP_002329978.1 2572255 R 574521 CDS YP_002329979.1 215487548 7063170 complement(2572731..2573222) 1 NC_011601.1 fimbrial protein 2573222 yfcR 7063170 yfcR Escherichia coli O127:H6 str. E2348/69 fimbrial protein YP_002329979.1 2572731 R 574521 CDS YP_002329980.1 215487549 7063171 complement(2573238..2573987) 1 NC_011601.1 chaperone 2573987 yfcS 7063171 yfcS Escherichia coli O127:H6 str. E2348/69 chaperone YP_002329980.1 2573238 R 574521 CDS YP_002329981.1 215487550 7063172 complement(2574007..2576646) 1 NC_011601.1 outer membrane usher protein 2576646 yfcU 7063172 yfcU Escherichia coli O127:H6 str. E2348/69 outer membrane usher protein YP_002329981.1 2574007 R 574521 CDS YP_002329982.1 215487551 7063173 complement(2576730..2577296) 1 NC_011601.1 fimbrial-protein like protein 2577296 yfcV 7063173 yfcV Escherichia coli O127:H6 str. E2348/69 fimbrial-protein like protein YP_002329982.1 2576730 R 574521 CDS YP_002329983.1 215487552 7063174 complement(2577959..2578444) 1 NC_011601.1 phosphohistidine phosphatase 2578444 sixA 7063174 sixA Escherichia coli O127:H6 str. E2348/69 phosphohistidine phosphatase YP_002329983.1 2577959 R 574521 CDS YP_002329984.1 215487553 7062718 complement(2578647..2580791) 1 NC_011601.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha 2580791 fadJ 7062718 fadJ Escherichia coli O127:H6 str. E2348/69 multifunctional fatty acid oxidation complex subunit alpha YP_002329984.1 2578647 R 574521 CDS YP_002329985.1 215487554 7062077 complement(2580791..2582101) 1 NC_011601.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase 2582101 fadI 7062077 fadI Escherichia coli O127:H6 str. E2348/69 3-ketoacyl-CoA thiolase YP_002329985.1 2580791 R 574521 CDS YP_002329986.1 215487555 7062076 complement(2582327..2582611) 1 NC_011601.1 hypothetical protein 2582611 yfcZ 7062076 yfcZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329986.1 2582327 R 574521 CDS YP_002329987.1 215487556 7063175 2582983..2584323 1 NC_011601.1 long-chain fatty acid outer membrane transporter 2584323 fadL 7063175 fadL Escherichia coli O127:H6 str. E2348/69 long-chain fatty acid outer membrane transporter YP_002329987.1 2582983 D 574521 CDS YP_002329988.1 215487557 7062079 complement(2584385..2585140) 1 NC_011601.1 lipoprotein 2585140 vacJ 7062079 vacJ Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002329988.1 2584385 R 574521 CDS YP_002329989.1 215487558 7062351 2585434..2586366 1 NC_011601.1 hypothetical protein 2586366 yfdC 7062351 yfdC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329989.1 2585434 D 574521 CDS YP_002329990.1 215487559 7061172 2586642..2587835 1 NC_011601.1 integrase 2587835 7061172 E2348C_2486 Escherichia coli O127:H6 str. E2348/69 integrase YP_002329990.1 2586642 D 574521 CDS YP_002329991.1 215487560 7060978 complement(2588257..2588625) 1 NC_011601.1 tail fiber assembly protein 2588625 7060978 E2348C_2487 Escherichia coli O127:H6 str. E2348/69 tail fiber assembly protein YP_002329991.1 2588257 R 574521 CDS YP_002329992.1 215487561 7060979 complement(2588622..2589650) 1 NC_011601.1 tail fiber protein 2589650 7060979 E2348C_2488 Escherichia coli O127:H6 str. E2348/69 tail fiber protein YP_002329992.1 2588622 R 574521 CDS YP_002329993.1 215487562 7060980 complement(2589650..2590330) 1 NC_011601.1 hypothetical protein 2590330 7060980 E2348C_2489 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329993.1 2589650 R 574521 CDS YP_002329994.1 215487563 7060981 complement(2590327..2591526) 1 NC_011601.1 hypothetical protein 2591526 7060981 E2348C_2490 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329994.1 2590327 R 574521 CDS YP_002329995.1 215487564 7060982 complement(2591526..2591879) 1 NC_011601.1 hypothetical protein 2591879 7060982 E2348C_2491 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329995.1 2591526 R 574521 CDS YP_002329996.1 215487565 7060983 complement(2591879..2592631) 1 NC_011601.1 baseplate assembly protein 2592631 7060983 E2348C_2492 Escherichia coli O127:H6 str. E2348/69 baseplate assembly protein YP_002329996.1 2591879 R 574521 CDS YP_002329997.1 215487566 7060984 complement(2592696..2593091) 1 NC_011601.1 hypothetical protein 2593091 7060984 E2348C_2493 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329997.1 2592696 R 574521 CDS YP_002329998.1 215487567 7060985 complement(2593078..2593848) 1 NC_011601.1 hypothetical protein 2593848 7060985 E2348C_2494 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329998.1 2593078 R 574521 CDS YP_002329999.1 215487568 7060986 complement(2593969..2594310) 1 NC_011601.1 hypothetical protein 2594310 7060986 E2348C_2495 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002329999.1 2593969 R 574521 CDS YP_002330000.1 215487569 7060987 complement(2594313..2595374) 1 NC_011601.1 hypothetical protein 2595374 7060987 E2348C_2496 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330000.1 2594313 R 574521 CDS YP_002330001.1 215487570 7060988 complement(2595377..2595679) 1 NC_011601.1 hypothetical protein 2595679 7060988 E2348C_2497 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330001.1 2595377 R 574521 CDS YP_002330002.1 215487571 7060989 complement(2595679..2596266) 1 NC_011601.1 hypothetical protein 2596266 7060989 E2348C_2498 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330002.1 2595679 R 574521 CDS YP_002330003.1 215487572 7060990 complement(2596266..2598254) 1 NC_011601.1 hypothetical protein 2598254 7060990 E2348C_2499 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330003.1 2596266 R 574521 CDS YP_002330004.1 215487573 7060991 complement(2598432..2598884) 1 NC_011601.1 hypothetical protein 2598884 7060991 E2348C_2500 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330004.1 2598432 R 574521 CDS YP_002330005.1 215487574 7060992 complement(2598888..2599328) 1 NC_011601.1 hypothetical protein 2599328 7060992 E2348C_2501 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330005.1 2598888 R 574521 CDS YP_002330006.1 215487575 7060993 complement(2599340..2600485) 1 NC_011601.1 hypothetical protein 2600485 7060993 E2348C_2502 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330006.1 2599340 R 574521 CDS YP_002330007.1 215487576 7060994 complement(2600489..2601037) 1 NC_011601.1 hypothetical protein 2601037 7060994 E2348C_2503 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330007.1 2600489 R 574521 CDS YP_002330008.1 215487577 7060995 complement(2601027..2601416) 1 NC_011601.1 hypothetical protein 2601416 7060995 E2348C_2504 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330008.1 2601027 R 574521 CDS YP_002330009.1 215487578 7060996 complement(2601403..2601957) 1 NC_011601.1 hypothetical protein 2601957 7060996 E2348C_2505 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330009.1 2601403 R 574521 CDS YP_002330010.1 215487579 7060997 complement(2601954..2602361) 1 NC_011601.1 hypothetical protein 2602361 7060997 E2348C_2506 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330010.1 2601954 R 574521 CDS YP_002330011.1 215487580 7060998 complement(2602327..2602548) 1 NC_011601.1 hypothetical protein 2602548 7060998 E2348C_2507 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330011.1 2602327 R 574521 CDS YP_002330012.1 215487581 7060999 complement(2602590..2603531) 1 NC_011601.1 hypothetical protein 2603531 7060999 E2348C_2508 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330012.1 2602590 R 574521 CDS YP_002330013.1 215487582 7061000 complement(2603543..2604049) 1 NC_011601.1 hypothetical protein 2604049 7061000 E2348C_2509 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330013.1 2603543 R 574521 CDS YP_002330014.1 215487583 7061001 complement(2604053..2605273) 1 NC_011601.1 hypothetical protein 2605273 7061001 E2348C_2510 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330014.1 2604053 R 574521 CDS YP_002330015.1 215487584 7061002 complement(2605288..2605896) 1 NC_011601.1 head morphogenesis protein 2605896 7061002 E2348C_2511 Escherichia coli O127:H6 str. E2348/69 head morphogenesis protein YP_002330015.1 2605288 R 574521 CDS YP_002330016.1 215487585 7061003 complement(2605934..2607379) 1 NC_011601.1 portal protein 2607379 7061003 E2348C_2512 Escherichia coli O127:H6 str. E2348/69 portal protein YP_002330016.1 2605934 R 574521 CDS YP_002330017.1 215487586 7061004 complement(2607379..2609001) 1 NC_011601.1 terminase large subunit 2609001 7061004 E2348C_2513 Escherichia coli O127:H6 str. E2348/69 terminase large subunit YP_002330017.1 2607379 R 574521 CDS YP_002330018.1 215487587 7061005 complement(2609004..2609555) 1 NC_011601.1 terminase, small subunit 2609555 7061005 E2348C_2514 Escherichia coli O127:H6 str. E2348/69 terminase, small subunit YP_002330018.1 2609004 R 574521 CDS YP_002330019.1 215487588 7061006 complement(2610256..2610468) 1 NC_011601.1 hypothetical protein 2610468 7061006 E2348C_2515 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330019.1 2610256 R 574521 CDS YP_002330020.1 215487589 7061007 complement(2610585..2610977) 1 NC_011601.1 hypothetical protein 2610977 7061007 E2348C_2516 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330020.1 2610585 R 574521 CDS YP_002330021.1 215487590 7061008 complement(2610961..2611437) 1 NC_011601.1 endolysin 2611437 7061008 E2348C_2517 Escherichia coli O127:H6 str. E2348/69 endolysin YP_002330021.1 2610961 R 574521 CDS YP_002330022.1 215487591 7061009 complement(2611421..2611744) 1 NC_011601.1 holin protein 2611744 7061009 E2348C_2518 Escherichia coli O127:H6 str. E2348/69 holin protein YP_002330022.1 2611421 R 574521 CDS YP_002330023.1 215487592 7062252 complement(2612197..2612709) 1 NC_011601.1 HNH endonuclease 2612709 7062252 E2348C_2519 Escherichia coli O127:H6 str. E2348/69 HNH endonuclease YP_002330023.1 2612197 R 574521 CDS YP_002330024.1 215487593 7061011 complement(2612904..2613422) 1 NC_011601.1 late gene regulator 2613422 7061011 E2348C_2520 Escherichia coli O127:H6 str. E2348/69 late gene regulator YP_002330024.1 2612904 R 574521 CDS YP_002330025.1 215487594 7061012 complement(2613604..2613966) 1 NC_011601.1 crossover junction endodeoxyribonuclease 2613966 7061012 E2348C_2521 Escherichia coli O127:H6 str. E2348/69 crossover junction endodeoxyribonuclease YP_002330025.1 2613604 R 574521 CDS YP_002330026.1 215487595 7061013 complement(2613963..2614253) 1 NC_011601.1 hypothetical protein 2614253 7061013 E2348C_2522 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330026.1 2613963 R 574521 CDS YP_002330027.1 215487596 7061014 complement(2614253..2614522) 1 NC_011601.1 hypothetical protein 2614522 7061014 E2348C_2523 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330027.1 2614253 R 574521 CDS YP_002330028.1 215487597 7061015 complement(2614515..2614691) 1 NC_011601.1 protein NinF 2614691 7061015 E2348C_2524 Escherichia coli O127:H6 str. E2348/69 protein NinF YP_002330028.1 2614515 R 574521 CDS YP_002330029.1 215487598 7061016 complement(2614691..2615050) 1 NC_011601.1 NinX 2615050 7061016 E2348C_2525 Escherichia coli O127:H6 str. E2348/69 NinX YP_002330029.1 2614691 R 574521 CDS YP_002330030.1 215487599 7061017 complement(2615053..2615229) 1 NC_011601.1 protein NinE 2615229 7061017 E2348C_2526 Escherichia coli O127:H6 str. E2348/69 protein NinE YP_002330030.1 2615053 R 574521 CDS YP_002330031.1 215487600 7061018 complement(2615226..2615753) 1 NC_011601.1 DNA methylase 2615753 7061018 E2348C_2527 Escherichia coli O127:H6 str. E2348/69 DNA methylase YP_002330031.1 2615226 R 574521 CDS YP_002330032.1 215487601 7065452 complement(2615750..2616190) 1 NC_011601.1 protein NinB 2616190 7065452 E2348C_2528 Escherichia coli O127:H6 str. E2348/69 protein NinB YP_002330032.1 2615750 R 574521 CDS YP_002330033.1 215487602 7065532 complement(2616264..2617640) 1 NC_011601.1 replicative DNA helicase 2617640 7065532 E2348C_2529 Escherichia coli O127:H6 str. E2348/69 replicative DNA helicase YP_002330033.1 2616264 R 574521 CDS YP_002330034.1 215487603 7065533 complement(2617637..2618584) 1 NC_011601.1 replication protein 2618584 7065533 E2348C_2530 Escherichia coli O127:H6 str. E2348/69 replication protein YP_002330034.1 2617637 R 574521 CDS YP_002330035.1 215487604 7065534 complement(2618587..2618859) 1 NC_011601.1 hypothetical protein 2618859 7065534 E2348C_2531 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330035.1 2618587 R 574521 CDS YP_002330036.1 215487605 7065535 complement(2618882..2619178) 1 NC_011601.1 regulatory protein 2619178 7065535 E2348C_2532 Escherichia coli O127:H6 str. E2348/69 regulatory protein YP_002330036.1 2618882 R 574521 CDS YP_002330037.1 215487606 7065536 complement(2619317..2619517) 1 NC_011601.1 antirepressor protein 2619517 7065536 E2348C_2533 Escherichia coli O127:H6 str. E2348/69 antirepressor protein YP_002330037.1 2619317 R 574521 CDS YP_002330038.1 215487607 7065537 2619618..2620331 1 NC_011601.1 repressor protein 2620331 7065537 E2348C_2534 Escherichia coli O127:H6 str. E2348/69 repressor protein YP_002330038.1 2619618 D 574521 CDS YP_002330039.1 215487608 7065538 2620339..2620776 1 NC_011601.1 hypothetical protein 2620776 7065538 E2348C_2535 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330039.1 2620339 D 574521 CDS YP_002330040.1 215487609 7065539 2620763..2621134 1 NC_011601.1 hypothetical protein 2621134 7065539 E2348C_2536 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330040.1 2620763 D 574521 CDS YP_002330041.1 215487610 7065540 2621636..2622019 1 NC_011601.1 early gene regulator 2622019 7065540 E2348C_2537 Escherichia coli O127:H6 str. E2348/69 early gene regulator YP_002330041.1 2621636 D 574521 CDS YP_002330042.1 215487611 7065541 2622078..2622548 1 NC_011601.1 hypothetical protein 2622548 7065541 E2348C_2538 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330042.1 2622078 D 574521 CDS YP_002330043.1 215487612 7065542 2622595..2622891 1 NC_011601.1 hypothetical protein 2622891 7065542 E2348C_2539 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330043.1 2622595 D 574521 CDS YP_002330044.1 215487613 7065543 2622891..2623079 1 NC_011601.1 hypothetical protein 2623079 7065543 E2348C_2540 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330044.1 2622891 D 574521 CDS YP_002330045.1 215487614 7065544 2623214..2624182 1 NC_011601.1 hypothetical protein 2624182 7065544 E2348C_2541 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330045.1 2623214 D 574521 CDS YP_002330046.1 215487615 7065545 2624206..2624337 1 NC_011601.1 regulatory protein 2624337 7065545 E2348C_2542 Escherichia coli O127:H6 str. E2348/69 regulatory protein YP_002330046.1 2624206 D 574521 CDS YP_002330047.1 215487616 7065546 2624322..2624474 1 NC_011601.1 host-killing protein 2624474 7065546 E2348C_2543 Escherichia coli O127:H6 str. E2348/69 host-killing protein YP_002330047.1 2624322 D 574521 CDS YP_002330048.1 215487617 7065547 2624471..2624629 1 NC_011601.1 hypothetical protein 2624629 7065547 E2348C_2544 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330048.1 2624471 D 574521 CDS YP_002330049.1 215487618 7065548 2624729..2625436 1 NC_011601.1 hypothetical protein 2625436 7065548 E2348C_2545 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330049.1 2624729 D 574521 CDS YP_002330050.1 215487619 7065549 2625437..2625904 1 NC_011601.1 hypothetical protein 2625904 7065549 E2348C_2546 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330050.1 2625437 D 574521 CDS YP_002330051.1 215487620 7065550 2625901..2626407 1 NC_011601.1 single stranded DNA-binding protein 2626407 7065550 E2348C_2547 Escherichia coli O127:H6 str. E2348/69 single stranded DNA-binding protein YP_002330051.1 2625901 D 574521 CDS YP_002330052.1 215487621 7065551 2626421..2626714 1 NC_011601.1 anti-RecBCD protein 2626714 7065551 E2348C_2548 Escherichia coli O127:H6 str. E2348/69 anti-RecBCD protein YP_002330052.1 2626421 D 574521 CDS YP_002330053.1 215487622 7065552 2626889..2627158 1 NC_011601.1 hypothetical protein 2627158 7065552 E2348C_2549 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330053.1 2626889 D 574521 CDS YP_002330054.1 215487623 7065553 2627145..2627783 1 NC_011601.1 hypothetical protein 2627783 7065553 E2348C_2550 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330054.1 2627145 D 574521 CDS YP_002330055.1 215487624 7065554 2627979..2628374 1 NC_011601.1 hypothetical protein 2628374 7065554 E2348C_2551 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330055.1 2627979 D 574521 CDS YP_002330056.1 215487625 7065555 2628584..2629216 1 NC_011601.1 hypothetical protein 2629216 7065555 E2348C_2552 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330056.1 2628584 D 574521 CDS YP_002330057.1 215487626 7065556 2629542..2629742 1 NC_011601.1 response regulator inhibitor for tor operon 2629742 torI 7065556 torI Escherichia coli O127:H6 str. E2348/69 response regulator inhibitor for tor operon YP_002330057.1 2629542 D 574521 CDS YP_002330058.1 215487627 7062223 complement(2630270..2631517) 1 NC_011601.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 2631517 lacY 7062223 lacY Escherichia coli O127:H6 str. E2348/69 galactoside permease YP_002330058.1 2630270 R 574521 CDS YP_002330059.1 215487628 7065557 complement(2631579..2632502) 1 NC_011601.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase 2632502 7065557 E2348C_2555 Escherichia coli O127:H6 str. E2348/69 aminoimidazole riboside kinase YP_002330059.1 2631579 R 574521 CDS YP_002330060.1 215487629 7065558 2632718..2634151 1 NC_011601.1 sucrose-6 phosphate hydrolase 2634151 7065558 E2348C_2556 Escherichia coli O127:H6 str. E2348/69 sucrose-6 phosphate hydrolase YP_002330060.1 2632718 D 574521 CDS YP_002330061.1 215487630 7065559 complement(2634159..2635154) 1 NC_011601.1 sucrose operon repressor 2635154 7065559 E2348C_2557 Escherichia coli O127:H6 str. E2348/69 sucrose operon repressor YP_002330061.1 2634159 R 574521 CDS YP_002330062.1 215487631 7065066 complement(2637052..2638590) 1 NC_011601.1 multidrug efflux system 2638590 emrY 7065066 emrY Escherichia coli O127:H6 str. E2348/69 multidrug efflux system YP_002330062.1 2637052 R 574521 CDS YP_002330063.1 215487632 7063848 complement(2638590..2639753) 1 NC_011601.1 EmrKY-TolC multidrug resistance efflux pump protein K, membrane fusion protein component 2639753 emrK 7063848 emrK Escherichia coli O127:H6 str. E2348/69 EmrKY-TolC multidrug resistance efflux pump protein K, membrane fusion protein component YP_002330063.1 2638590 R 574521 CDS YP_002330064.1 215487633 7063847 2640168..2640782 1 NC_011601.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2640782 evgA 7063847 evgA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator EvgA YP_002330064.1 2640168 D 574521 CDS YP_002330065.1 215487634 7063903 2640787..2644380 1 NC_011601.1 hybrid sensory histidine kinase in two-component regulatory system with EvgA 2644380 evgS 7063903 evgS Escherichia coli O127:H6 str. E2348/69 hybrid sensory histidine kinase in two-component regulatory system with EvgA YP_002330065.1 2640787 D 574521 CDS YP_002330066.1 215487635 7063904 complement(2644436..2645581) 1 NC_011601.1 hypothetical protein 2645581 yfdE 7063904 yfdE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330066.1 2644436 R 574521 CDS YP_002330067.1 215487636 7063177 complement(2645655..2646599) 1 NC_011601.1 member of the AEC family of auxin efflux transporters; unknown function; transporter YfdV 2646599 yfdV 7063177 yfdV Escherichia coli O127:H6 str. E2348/69 transporter YfdV YP_002330067.1 2645655 R 574521 CDS YP_002330068.1 215487637 7063178 complement(2646669..2648363) 1 NC_011601.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase 2648363 oxc 7063178 oxc Escherichia coli O127:H6 str. E2348/69 oxalyl-CoA decarboxylase YP_002330068.1 2646669 R 574521 CDS YP_002330069.1 215487638 7062896 complement(2648417..2649667) 1 NC_011601.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 2649667 frc 7062896 frc Escherichia coli O127:H6 str. E2348/69 formyl-coenzyme A transferase YP_002330069.1 2648417 R 574521 CDS YP_002330070.1 215487639 7061948 complement(2650179..2650811) 1 NC_011601.1 hypothetical protein 2650811 yfdX 7061948 yfdX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330070.1 2650179 R 574521 CDS YP_002330071.1 215487640 7063179 2651106..2651381 1 NC_011601.1 lipoprotein involved in colanic acid biosynthesis 2651381 ypdI 7063179 ypdI Escherichia coli O127:H6 str. E2348/69 lipoprotein involved in colanic acid biosynthesis YP_002330071.1 2651106 D 574521 CDS YP_002330072.1 215487641 7061235 complement(2651458..2651700) 1 NC_011601.1 hypothetical protein 2651700 yfdY 7061235 yfdY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330072.1 2651458 R 574521 CDS YP_002330073.1 215487642 7063180 2652053..2652973 1 NC_011601.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2652973 lpxP 7063180 lpxP Escherichia coli O127:H6 str. E2348/69 lipid A biosynthesis palmitoleoyl acyltransferase YP_002330073.1 2652053 D 574521 CDS YP_002330074.1 215487643 7061099 complement(2653465..2654703) 1 NC_011601.1 aminotransferase 2654703 yfdZ 7061099 yfdZ Escherichia coli O127:H6 str. E2348/69 aminotransferase YP_002330074.1 2653465 R 574521 CDS YP_002330075.1 215487644 7063181 2655080..2656777 1 NC_011601.1 sensory kinase in two-component system with YpdB 2656777 ypdA 7063181 ypdA Escherichia coli O127:H6 str. E2348/69 sensory kinase in two-component system with YpdB YP_002330075.1 2655080 D 574521 CDS YP_002330076.1 215487645 7061230 2656792..2657526 1 NC_011601.1 response regulator in two-component system with YpdA 2657526 ypdB 7061230 ypdB Escherichia coli O127:H6 str. E2348/69 response regulator in two-component system with YpdA YP_002330076.1 2656792 D 574521 CDS YP_002330077.1 215487646 7061231 2657539..2658396 1 NC_011601.1 DNA-binding protein 2658396 ypdC 7061231 ypdC Escherichia coli O127:H6 str. E2348/69 DNA-binding protein YP_002330077.1 2657539 D 574521 CDS YP_002330078.1 215487647 7061232 complement(2658399..2660894) 1 NC_011601.1 fused PTS enzymes: Hpr component/enzyme I component/enzyme IIA component 2660894 fryA 7061232 fryA Escherichia coli O127:H6 str. E2348/69 fused PTS enzymes: Hpr component/enzyme I component/enzyme IIA component YP_002330078.1 2658399 R 574521 CDS YP_002330079.1 215487648 7061970 complement(2660919..2661956) 1 NC_011601.1 metalloprotein; exoaminopeptidase 2661956 ypdE 7061970 ypdE Escherichia coli O127:H6 str. E2348/69 exoaminopeptidase YP_002330079.1 2660919 R 574521 CDS YP_002330080.1 215487649 7061233 complement(2661956..2663041) 1 NC_011601.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase 2663041 ypdF 7061233 ypdF Escherichia coli O127:H6 str. E2348/69 aminopeptidase YP_002330080.1 2661956 R 574521 CDS YP_002330081.1 215487650 7061234 complement(2663056..2664303) 1 NC_011601.1 enzyme IIC component of PTS 2664303 fryC 7061234 fryC Escherichia coli O127:H6 str. E2348/69 enzyme IIC component of PTS YP_002330081.1 2663056 R 574521 CDS YP_002330082.1 215487651 7061971 complement(2664870..2665835) 1 NC_011601.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 2665835 glk 7061971 glk Escherichia coli O127:H6 str. E2348/69 glucokinase YP_002330082.1 2664870 R 574521 CDS YP_002330083.1 215487652 7061672 2666039..2667295 1 NC_011601.1 hypothetical protein 2667295 yfeO 7061672 yfeO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330083.1 2666039 D 574521 CDS YP_002330084.1 215487653 7064370 2667410..2667736 1 NC_011601.1 hypothetical protein 2667736 ypeC 7064370 ypeC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330084.1 2667410 D 574521 CDS YP_002330085.1 215487654 7061238 complement(2667877..2669115) 1 NC_011601.1 manganese transport protein MntH 2669115 mntH 7061238 mntH Escherichia coli O127:H6 str. E2348/69 manganese transport protein MntH YP_002330085.1 2667877 R 574521 CDS YP_002330086.1 215487655 7063803 2669451..2670653 1 NC_011601.1 nucleoside (except guanosine) transporter 2670653 nupC 7063803 nupC Escherichia coli O127:H6 str. E2348/69 nucleoside (except guanosine) transporter YP_002330086.1 2669451 D 574521 CDS YP_002330087.1 215487656 7065450 complement(2670703..2672892) 1 NC_011601.1 diguanylate cyclase 2672892 yfeA 7065450 yfeA Escherichia coli O127:H6 str. E2348/69 diguanylate cyclase YP_002330087.1 2670703 R 574521 CDS YP_002330088.1 215487657 7062433 2673510..2673869 1 NC_011601.1 DNA-binding transcriptional regulator 2673869 yfeC 7062433 yfeC Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330088.1 2673510 D 574521 CDS YP_002330089.1 215487658 7064310 2673871..2674263 1 NC_011601.1 DNA-binding transcriptional regulator 2674263 yfeD 7064310 yfeD Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330089.1 2673871 D 574521 CDS YP_002330090.1 215487659 7064366 complement(2674314..2675729) 1 NC_011601.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2675729 gltX 7064366 gltX Escherichia coli O127:H6 str. E2348/69 glutamyl-tRNA synthetase YP_002330090.1 2674314 R 574521 CDS YP_002330091.1 215487660 7064858 complement(2677646..2678902) 1 NC_011601.1 xanthosine transporter 2678902 xapB 7064858 xapB Escherichia coli O127:H6 str. E2348/69 xanthosine transporter YP_002330091.1 2677646 R 574521 CDS YP_002330092.1 215487661 7064857 complement(2678963..2679796) 1 NC_011601.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 2679796 xapA 7064857 xapA Escherichia coli O127:H6 str. E2348/69 purine nucleoside phosphorylase YP_002330092.1 2678963 R 574521 CDS YP_002330093.1 215487662 7064856 2680044..2680808 1 NC_011601.1 hypothetical protein 2680808 yfeN 7064856 yfeN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330093.1 2680044 D 574521 CDS YP_002330094.1 215487663 7064369 complement(2680847..2681773) 1 NC_011601.1 DNA-binding transcriptional regulator 2681773 yfeR 7064369 yfeR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330094.1 2680847 R 574521 CDS YP_002330095.1 215487664 7064371 2681863..2682861 1 NC_011601.1 hypothetical protein 2682861 yfeH 7064371 yfeH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330095.1 2681863 D 574521 CDS YP_002330096.1 215487665 7064367 complement(2682858..2683076) 1 NC_011601.1 hypothetical protein 2683076 ypeB 7064367 ypeB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330096.1 2682858 R 574521 CDS YP_002330097.1 215487666 7061237 complement(2683078..2685093) 1 NC_011601.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2685093 ligA 7061237 ligA Escherichia coli O127:H6 str. E2348/69 NAD-dependent DNA ligase LigA YP_002330097.1 2683078 R 574521 CDS YP_002330098.1 215487667 7061539 complement(2685164..2686162) 1 NC_011601.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 2686162 zipA 7061539 zipA Escherichia coli O127:H6 str. E2348/69 cell division protein ZipA YP_002330098.1 2685164 R 574521 CDS YP_002330099.1 215487668 7063259 2686392..2687153 1 NC_011601.1 role in sulfur assimilation; sulfate transport protein CysZ 2687153 cysZ 7063259 cysZ Escherichia coli O127:H6 str. E2348/69 sulfate transport protein CysZ YP_002330099.1 2686392 D 574521 CDS YP_002330100.1 215487669 7065210 2687338..2688309 1 NC_011601.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2688309 cysK 7065210 cysK Escherichia coli O127:H6 str. E2348/69 cysteine synthase A YP_002330100.1 2687338 D 574521 CDS YP_002330101.1 215487670 7065202 2688693..2688950 1 NC_011601.1 PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr 2688950 ptsH 7065202 ptsH Escherichia coli O127:H6 str. E2348/69 PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr YP_002330101.1 2688693 D 574521 CDS YP_002330102.1 215487671 7061339 2688995..2690722 1 NC_011601.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2690722 ptsI 7061339 ptsI Escherichia coli O127:H6 str. E2348/69 phosphoenolpyruvate-protein phosphotransferase YP_002330102.1 2688995 D 574521 CDS YP_002330103.1 215487672 7063908 2690763..2691272 1 NC_011601.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter 2691272 crr 7063908 crr Escherichia coli O127:H6 str. E2348/69 PTS system glucose-specific transporter YP_002330103.1 2690763 D 574521 CDS YP_002330104.1 215487673 7062848 complement(2691314..2692165) 1 NC_011601.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase 2692165 pdxK 7062848 pdxK Escherichia coli O127:H6 str. E2348/69 pyridoxal kinase YP_002330104.1 2691314 R 574521 CDS YP_002330105.1 215487674 7062943 2692270..2692638 1 NC_011601.1 hypothetical protein 2692638 yfeK 7062943 yfeK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330105.1 2692270 D 574521 CDS YP_002330106.1 215487675 7064368 complement(2692641..2693552) 1 NC_011601.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B 2693552 cysM 7064368 cysM Escherichia coli O127:H6 str. E2348/69 cysteine synthase B YP_002330106.1 2692641 R 574521 CDS YP_002330107.1 215487676 7065203 complement(2693686..2694783) 1 NC_011601.1 sulfate/thiosulfate transporter subunit 2694783 cysA 7065203 cysA Escherichia coli O127:H6 str. E2348/69 sulfate/thiosulfate transporter subunit YP_002330107.1 2693686 R 574521 CDS YP_002330108.1 215487677 7065193 complement(2694773..2695648) 1 NC_011601.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit 2695648 cysW 7065193 cysW Escherichia coli O127:H6 str. E2348/69 sulfate/thiosulfate transporter permease subunit YP_002330108.1 2694773 R 574521 CDS YP_002330109.1 215487678 7065209 complement(2695648..2696481) 1 NC_011601.1 sulfate/thiosulfate transporter subunit 2696481 cysU 7065209 cysU Escherichia coli O127:H6 str. E2348/69 sulfate/thiosulfate transporter subunit YP_002330109.1 2695648 R 574521 CDS YP_002330110.1 215487679 7065208 complement(2696481..2697497) 1 NC_011601.1 thiosulfate transporter subunit 2697497 cysP 7065208 cysP Escherichia coli O127:H6 str. E2348/69 thiosulfate transporter subunit YP_002330110.1 2696481 R 574521 CDS YP_002330111.1 215487680 7061103 2697802..2699175 1 NC_011601.1 transposase of ISEc13 2699175 7061103 E2348C_2611 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002330111.1 2697802 D 574521 CDS YP_002330112.1 215487681 7065561 complement(2699215..2700006) 1 NC_011601.1 short chain dehydrogenase 2700006 ucpA 7065561 ucpA Escherichia coli O127:H6 str. E2348/69 short chain dehydrogenase YP_002330112.1 2699215 R 574521 CDS YP_002330113.1 215487682 7062299 2700286..2701182 1 NC_011601.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 2701182 murQ 7062299 murQ Escherichia coli O127:H6 str. E2348/69 N-acetylmuramic acid 6-phosphate etherase YP_002330113.1 2700286 D 574521 CDS YP_002330114.1 215487683 7060896 2701186..2702610 1 NC_011601.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunit IIBC 2702610 murP 7060896 murP Escherichia coli O127:H6 str. E2348/69 PTS system N-acetylmuramic acid transporter subunit IIBC YP_002330114.1 2701186 D 574521 CDS YP_002330115.1 215487684 7060895 complement(2702790..2703689) 1 NC_011601.1 hypothetical protein 2703689 yfeX 7060895 yfeX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330115.1 2702790 R 574521 CDS YP_002330116.1 215487685 7064372 complement(2703785..2704360) 1 NC_011601.1 hypothetical protein 2704360 yfeY 7064372 yfeY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330116.1 2703785 R 574521 CDS YP_002330117.1 215487686 7064373 complement(2704421..2704870) 1 NC_011601.1 hypothetical protein 2704870 yfeZ 7064373 yfeZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330117.1 2704421 R 574521 CDS YP_002330118.1 215487687 7064374 complement(2704857..2705282) 1 NC_011601.1 acetyltransferase 2705282 ypeA 7064374 ypeA Escherichia coli O127:H6 str. E2348/69 acetyltransferase YP_002330118.1 2704857 R 574521 CDS YP_002330119.1 215487688 7061236 2705496..2706365 1 NC_011601.1 N-acetylmuramoyl-L-alanine amidase 2706365 amiA 7061236 amiA Escherichia coli O127:H6 str. E2348/69 N-acetylmuramoyl-L-alanine amidase YP_002330119.1 2705496 D 574521 CDS YP_002330120.1 215487689 7062452 2706369..2707268 1 NC_011601.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2707268 hemF 7062452 hemF Escherichia coli O127:H6 str. E2348/69 coproporphyrinogen III oxidase YP_002330120.1 2706369 D 574521 CDS YP_002330121.1 215487690 7064296 2707312..2707983 1 NC_011601.1 hypothetical protein 2707983 7064296 E2348C_2621 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330121.1 2707312 D 574521 CDS YP_002330122.1 215487691 7065562 complement(2707980..2711429) 1 NC_011601.1 helicase 2711429 7065562 E2348C_2622 Escherichia coli O127:H6 str. E2348/69 helicase YP_002330122.1 2707980 R 574521 CDS YP_002330123.1 215487692 7065563 2711528..2712790 1 NC_011601.1 hypothetical protein 2712790 7065563 E2348C_2623 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330123.1 2711528 D 574521 CDS YP_002330124.1 215487693 7065564 2712831..2713148 1 NC_011601.1 hypothetical protein 2713148 7065564 E2348C_2624 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330124.1 2712831 D 574521 CDS YP_002330125.1 215487694 7065565 complement(2713227..2714279) 1 NC_011601.1 activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR 2714279 eutR 7065565 eutR Escherichia coli O127:H6 str. E2348/69 transcriptional regulator EutR YP_002330125.1 2713227 R 574521 CDS YP_002330126.1 215487695 7063900 complement(2714325..2714825) 1 NC_011601.1 carboxysome structural protein with role in ethanolamine utilization 2714825 eutK 7063900 eutK Escherichia coli O127:H6 str. E2348/69 carboxysome structural protein with role in ethanolamine utilization YP_002330126.1 2714325 R 574521 CDS YP_002330127.1 215487696 7063894 complement(2714838..2715497) 1 NC_011601.1 carboxysome structural protein with role in ethanolamine utilization 2715497 eutL 7063894 eutL Escherichia coli O127:H6 str. E2348/69 carboxysome structural protein with role in ethanolamine utilization YP_002330127.1 2714838 R 574521 CDS YP_002330128.1 215487697 7061173 complement(2716247..2716894) 1 NC_011601.1 repressor protein 2716894 7061173 E2348C_2629 Escherichia coli O127:H6 str. E2348/69 repressor protein YP_002330128.1 2716247 R 574521 CDS YP_002330129.1 215487698 7065566 2717077..2717313 1 NC_011601.1 DNA-binding protein 2717313 7065566 E2348C_2630 Escherichia coli O127:H6 str. E2348/69 DNA-binding protein YP_002330129.1 2717077 D 574521 CDS YP_002330130.1 215487699 7065567 2717313..2719355 1 NC_011601.1 DNA transposition protein 2719355 7065567 E2348C_2631 Escherichia coli O127:H6 str. E2348/69 DNA transposition protein YP_002330130.1 2717313 D 574521 CDS YP_002330131.1 215487700 7065568 2719374..2720267 1 NC_011601.1 DNA transposition protein 2720267 7065568 E2348C_2632 Escherichia coli O127:H6 str. E2348/69 DNA transposition protein YP_002330131.1 2719374 D 574521 CDS YP_002330132.1 215487701 7065569 2720282..2720506 1 NC_011601.1 hypothetical protein 2720506 7065569 E2348C_2633 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330132.1 2720282 D 574521 CDS YP_002330133.1 215487702 7065570 2720763..2721407 1 NC_011601.1 hypothetical protein 2721407 7065570 E2348C_2634 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330133.1 2720763 D 574521 CDS YP_002330134.1 215487703 7065571 2721409..2721642 1 NC_011601.1 hypothetical protein 2721642 7065571 E2348C_2635 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330134.1 2721409 D 574521 CDS YP_002330135.1 215487704 7065572 2721623..2721814 1 NC_011601.1 hypothetical protein 2721814 7065572 E2348C_2636 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330135.1 2721623 D 574521 CDS YP_002330136.1 215487705 7065573 complement(2721955..2722173) 1 NC_011601.1 hypothetical protein 2722173 7065573 E2348C_2637 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330136.1 2721955 R 574521 CDS YP_002330137.1 215487706 7065574 2722262..2722972 1 NC_011601.1 hypothetical protein 2722972 7065574 E2348C_2638 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330137.1 2722262 D 574521 CDS YP_002330138.1 215487707 7065575 2722975..2723202 1 NC_011601.1 hypothetical protein 2723202 7065575 E2348C_2639 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330138.1 2722975 D 574521 CDS YP_002330139.1 215487708 7065576 2723199..2723429 1 NC_011601.1 hypothetical protein 2723429 7065576 E2348C_2640 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330139.1 2723199 D 574521 CDS YP_002330140.1 215487709 7065577 2723419..2723733 1 NC_011601.1 hypothetical protein 2723733 7065577 E2348C_2641 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330140.1 2723419 D 574521 CDS YP_002330141.1 215487710 7065578 2723705..2723869 1 NC_011601.1 hypothetical protein 2723869 7065578 E2348C_2642 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330141.1 2723705 D 574521 CDS YP_002330142.1 215487711 7065579 2723866..2724135 1 NC_011601.1 hypothetical protein 2724135 7065579 E2348C_2643 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330142.1 2723866 D 574521 CDS YP_002330143.1 215487712 7065580 2724122..2724619 1 NC_011601.1 hypothetical protein 2724619 7065580 E2348C_2644 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330143.1 2724122 D 574521 CDS YP_002330144.1 215487713 7065581 2724619..2724789 1 NC_011601.1 hypothetical protein 2724789 7065581 E2348C_2645 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330144.1 2724619 D 574521 CDS YP_002330145.1 215487714 7065582 2724786..2724974 1 NC_011601.1 hypothetical protein 2724974 7065582 E2348C_2646 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330145.1 2724786 D 574521 CDS YP_002330146.1 215487715 7065583 2725099..2725320 1 NC_011601.1 hypothetical protein 2725320 7065583 E2348C_2647 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330146.1 2725099 D 574521 CDS YP_002330147.1 215487716 7065584 2725292..2725690 1 NC_011601.1 hypothetical protein 2725690 7065584 E2348C_2648 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330147.1 2725292 D 574521 CDS YP_002330148.1 215487717 7065585 2725690..2726163 1 NC_011601.1 hypothetical protein 2726163 7065585 E2348C_2649 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330148.1 2725690 D 574521 CDS YP_002330149.1 215487718 7065586 2726264..2726731 1 NC_011601.1 hypothetical protein 2726731 7065586 E2348C_2650 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330149.1 2726264 D 574521 CDS YP_002330150.1 215487719 7065587 2726758..2727036 1 NC_011601.1 hypothetical protein 2727036 7065587 E2348C_2651 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330150.1 2726758 D 574521 CDS YP_002330151.1 215487720 7065588 2727219..2727611 1 NC_011601.1 membrane protein 2727611 7065588 E2348C_2652 Escherichia coli O127:H6 str. E2348/69 membrane protein YP_002330151.1 2727219 D 574521 CDS YP_002330152.1 215487721 7065589 2727601..2727897 1 NC_011601.1 holin protein 2727897 7065589 E2348C_2653 Escherichia coli O127:H6 str. E2348/69 holin protein YP_002330152.1 2727601 D 574521 CDS YP_002330153.1 215487722 7065590 2727881..2728426 1 NC_011601.1 hypothetical protein 2728426 7065590 E2348C_2654 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330153.1 2727881 D 574521 CDS YP_002330154.1 215487723 7065591 2728423..2728605 1 NC_011601.1 hypothetical protein 2728605 7065591 E2348C_2655 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330154.1 2728423 D 574521 CDS YP_002330155.1 215487724 7065592 2728832..2729332 1 NC_011601.1 DNA-binding protein 2729332 7065592 E2348C_2656 Escherichia coli O127:H6 str. E2348/69 DNA-binding protein YP_002330155.1 2728832 D 574521 CDS YP_002330156.1 215487725 7065593 2729379..2730119 1 NC_011601.1 methyltransferase 2730119 7065593 E2348C_2657 Escherichia coli O127:H6 str. E2348/69 methyltransferase YP_002330156.1 2729379 D 574521 CDS YP_002330157.1 215487726 7065594 2730121..2731761 1 NC_011601.1 hypothetical protein 2731761 7065594 E2348C_2658 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330157.1 2730121 D 574521 CDS YP_002330158.1 215487727 7065595 2731765..2733360 1 NC_011601.1 hypothetical protein 2733360 7065595 E2348C_2659 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330158.1 2731765 D 574521 CDS YP_002330159.1 215487728 7065596 2733347..2734513 1 NC_011601.1 head morphogenesis protein 2734513 7065596 E2348C_2660 Escherichia coli O127:H6 str. E2348/69 head morphogenesis protein YP_002330159.1 2733347 D 574521 CDS YP_002330160.1 215487729 7065597 2734510..2735061 1 NC_011601.1 virion morphogenesis protein 2735061 7065597 E2348C_2661 Escherichia coli O127:H6 str. E2348/69 virion morphogenesis protein YP_002330160.1 2734510 D 574521 CDS YP_002330161.1 215487730 7065598 2735271..2736386 1 NC_011601.1 hypothetical protein 2736386 7065598 E2348C_2662 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330161.1 2735271 D 574521 CDS YP_002330162.1 215487731 7065599 2736387..2736782 1 NC_011601.1 hypothetical protein 2736782 7065599 E2348C_2663 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330162.1 2736387 D 574521 CDS YP_002330163.1 215487732 7065600 2736793..2737701 1 NC_011601.1 major head subunit protein 2737701 7065600 E2348C_2664 Escherichia coli O127:H6 str. E2348/69 major head subunit protein YP_002330163.1 2736793 D 574521 CDS YP_002330164.1 215487733 7065601 2737705..2738037 1 NC_011601.1 hypothetical protein 2738037 7065601 E2348C_2665 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330164.1 2737705 D 574521 CDS YP_002330165.1 215487734 7065602 2738041..2738472 1 NC_011601.1 hypothetical protein 2738472 7065602 E2348C_2666 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330165.1 2738041 D 574521 CDS YP_002330166.1 215487735 7065603 2738529..2739107 1 NC_011601.1 hypothetical protein 2739107 7065603 E2348C_2667 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330166.1 2738529 D 574521 CDS YP_002330167.1 215487736 7065604 2739088..2739321 1 NC_011601.1 hypothetical protein 2739321 7065604 E2348C_2668 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330167.1 2739088 D 574521 CDS YP_002330168.1 215487737 7065605 2739314..2740735 1 NC_011601.1 tail sheath protein 2740735 7065605 E2348C_2669 Escherichia coli O127:H6 str. E2348/69 tail sheath protein YP_002330168.1 2739314 D 574521 CDS YP_002330169.1 215487738 7065606 2740748..2741122 1 NC_011601.1 hypothetical protein 2741122 7065606 E2348C_2670 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330169.1 2740748 D 574521 CDS YP_002330170.1 215487739 7065607 2741119..2741502 1 NC_011601.1 hypothetical protein 2741502 7065607 E2348C_2671 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330170.1 2741119 D 574521 CDS YP_002330171.1 215487740 7065608 2741665..2743938 1 NC_011601.1 tail length tape measure protein 2743938 7065608 E2348C_2672 Escherichia coli O127:H6 str. E2348/69 tail length tape measure protein YP_002330171.1 2741665 D 574521 CDS YP_002330172.1 215487741 7065609 2743938..2745287 1 NC_011601.1 DNA circulation protein 2745287 7065609 E2348C_2673 Escherichia coli O127:H6 str. E2348/69 DNA circulation protein YP_002330172.1 2743938 D 574521 CDS YP_002330173.1 215487742 7065610 2745271..2746482 1 NC_011601.1 tail protein 2746482 7065610 E2348C_2674 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002330173.1 2745271 D 574521 CDS YP_002330174.1 215487743 7065451 2746479..2747132 1 NC_011601.1 baseplate assembly protein 2747132 7065451 E2348C_2675 Escherichia coli O127:H6 str. E2348/69 baseplate assembly protein YP_002330174.1 2746479 D 574521 CDS YP_002330175.1 215487744 7065453 2747186..2747536 1 NC_011601.1 hypothetical protein 2747536 7065453 E2348C_2676 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330175.1 2747186 D 574521 CDS YP_002330176.1 215487745 7065454 2747536..2748615 1 NC_011601.1 tail protein 2748615 7065454 E2348C_2677 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002330176.1 2747536 D 574521 CDS YP_002330177.1 215487746 7065455 2748619..2749191 1 NC_011601.1 tail protein 2749191 7065455 E2348C_2678 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002330177.1 2748619 D 574521 CDS YP_002330178.1 215487747 7065456 2749275..2749940 1 NC_011601.1 tai fiber protein 2749940 7065456 E2348C_2679 Escherichia coli O127:H6 str. E2348/69 tai fiber protein YP_002330178.1 2749275 D 574521 CDS YP_002330179.1 215487748 7065457 2749940..2750533 1 NC_011601.1 tail fiber assembly protein 2750533 7065457 E2348C_2680 Escherichia coli O127:H6 str. E2348/69 tail fiber assembly protein YP_002330179.1 2749940 D 574521 CDS YP_002330180.1 215487749 7065458 complement(2750505..2750921) 1 NC_011601.1 tail fiber assembly protein 2750921 7065458 E2348C_2681 Escherichia coli O127:H6 str. E2348/69 tail fiber assembly protein YP_002330180.1 2750505 R 574521 CDS YP_002330181.1 215487750 7065459 complement(2750924..2751430) 1 NC_011601.1 hypothetical protein 2751430 7065459 E2348C_2682 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330181.1 2750924 R 574521 CDS YP_002330182.1 215487751 7065460 complement(2752155..2753516) 1 NC_011601.1 ethanolamine ammonia-lyase, large subunit, heavychain 2753516 eutB 7065460 eutB Escherichia coli O127:H6 str. E2348/69 ethanolamine ammonia-lyase, large subunit, heavychain YP_002330182.1 2752155 R 574521 CDS YP_002330183.1 215487752 7061104 complement(2754775..2756148) 1 NC_011601.1 transposase of ISEc13 2756148 7061104 E2348C_2685 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002330183.1 2754775 R 574521 CDS YP_002330184.1 215487753 7065461 complement(2756488..2757714) 1 NC_011601.1 predicter inner membrane protein 2757714 eutH 7065461 eutH Escherichia coli O127:H6 str. E2348/69 predicter inner membrane protein YP_002330184.1 2756488 R 574521 CDS YP_002330185.1 215487754 7063892 complement(2757931..2759118) 1 NC_011601.1 alcohol dehydrogenase in ethanolamineutilization 2759118 eutG 7063892 eutG Escherichia coli O127:H6 str. E2348/69 alcohol dehydrogenase in ethanolamineutilization YP_002330185.1 2757931 R 574521 CDS YP_002330186.1 215487755 7063891 complement(2759108..2759944) 1 NC_011601.1 chaperonin, ethanolamine utilization protein EutJ 2759944 eutJ 7063891 eutJ Escherichia coli O127:H6 str. E2348/69 chaperonin, ethanolamine utilization protein EutJ YP_002330186.1 2759108 R 574521 CDS YP_002330187.1 215487756 7063893 complement(2759955..2761358) 1 NC_011601.1 aldehyde dehydrogenase 2761358 eutE 7063893 eutE Escherichia coli O127:H6 str. E2348/69 aldehyde dehydrogenase YP_002330187.1 2759955 R 574521 CDS YP_002330188.1 215487757 7063890 complement(2761370..2761657) 1 NC_011601.1 carboxysome structural protein, ethanolamine utilization protein 2761657 eutN 7063890 eutN Escherichia coli O127:H6 str. E2348/69 carboxysome structural protein, ethanolamine utilization protein YP_002330188.1 2761370 R 574521 CDS YP_002330189.1 215487758 7063897 complement(2761764..2762057) 1 NC_011601.1 carboxysome structural protein, ethanolamine utilization protein 2762057 eutM 7063897 eutM Escherichia coli O127:H6 str. E2348/69 carboxysome structural protein, ethanolamine utilization protein YP_002330189.1 2761764 R 574521 CDS YP_002330190.1 215487759 7063896 complement(2762096..2763112) 1 NC_011601.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 2763112 eutD 7063896 eutD Escherichia coli O127:H6 str. E2348/69 phosphotransacetylase YP_002330190.1 2762096 R 574521 CDS YP_002330191.1 215487760 7063889 complement(2763109..2763912) 1 NC_011601.1 cobalamin adenosyltransferase in ethanolamine utilization 2763912 eutT 7063889 eutT Escherichia coli O127:H6 str. E2348/69 cobalamin adenosyltransferase in ethanolamine utilization YP_002330191.1 2763109 R 574521 CDS YP_002330192.1 215487761 7063902 complement(2763909..2764610) 1 NC_011601.1 hypothetical protein 2764610 eutQ 7063902 eutQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330192.1 2763909 R 574521 CDS YP_002330193.1 215487762 7063899 complement(2764585..2765064) 1 NC_011601.1 hypothetical protein 2765064 eutP 7063899 eutP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330193.1 2764585 R 574521 CDS YP_002330194.1 215487763 7063898 complement(2765077..2765412) 1 NC_011601.1 carboxysome structural protein with role in ethanol utilization 2765412 eutS 7063898 eutS Escherichia coli O127:H6 str. E2348/69 carboxysome structural protein with role in ethanol utilization YP_002330194.1 2765077 R 574521 CDS YP_002330195.1 215487764 7063901 complement(2765704..2767983) 1 NC_011601.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 2767983 maeB 7063901 maeB Escherichia coli O127:H6 str. E2348/69 malic enzyme YP_002330195.1 2765704 R 574521 CDS YP_002330196.1 215487765 7065268 2768272..2769222 1 NC_011601.1 transaldolase A 2769222 talA 7065268 talA Escherichia coli O127:H6 str. E2348/69 transaldolase A YP_002330196.1 2768272 D 574521 CDS YP_002330197.1 215487766 7061749 2769242..2771245 1 NC_011601.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2771245 tktB 7061749 tktB Escherichia coli O127:H6 str. E2348/69 transketolase YP_002330197.1 2769242 D 574521 CDS YP_002330198.1 215487767 7061807 complement(2771322..2772365) 1 NC_011601.1 hypothetical protein 2772365 ypfG 7061807 ypfG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330198.1 2771322 R 574521 CDS YP_002330199.1 215487768 7061239 complement(2772491..2773066) 1 NC_011601.1 NUDIX hydrolase 2773066 nudK 7061239 nudK Escherichia coli O127:H6 str. E2348/69 NUDIX hydrolase YP_002330199.1 2772491 R 574521 CDS YP_002330200.1 215487769 7065435 complement(2773134..2775113) 1 NC_011601.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit 2775113 aegA 7065435 aegA Escherichia coli O127:H6 str. E2348/69 oxidoreductase Fe-S binding subunit YP_002330200.1 2773134 R 574521 CDS YP_002330201.1 215487770 7062413 2775319..2777037 1 NC_011601.1 nitrate/nitrite sensor protein NarQ 2777037 narQ 7062413 narQ Escherichia coli O127:H6 str. E2348/69 nitrate/nitrite sensor protein NarQ YP_002330201.1 2775319 D 574521 CDS YP_002330202.1 215487771 7060938 complement(2777124..2780297) 1 NC_011601.1 AidA autotransporter-like protein 2780297 7060938 E2348C_2704 Escherichia coli O127:H6 str. E2348/69 AidA autotransporter-like protein YP_002330202.1 2777124 R 574521 CDS YP_002330203.1 215487772 7065462 complement(2780301..2781536) 1 NC_011601.1 glycosyl transferase family protein 2781536 7065462 E2348C_2705 Escherichia coli O127:H6 str. E2348/69 glycosyl transferase family protein YP_002330203.1 2780301 R 574521 CDS YP_002330204.1 215487773 7065463 2782674..2785787 1 NC_011601.1 aminoglycoside/multidrug efflux system 2785787 acrD 7065463 acrD Escherichia coli O127:H6 str. E2348/69 aminoglycoside/multidrug efflux system YP_002330204.1 2782674 D 574521 CDS YP_002330205.1 215487774 7062398 2786326..2786682 1 NC_011601.1 hypothetical protein 2786682 yffB 7062398 yffB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330205.1 2786326 D 574521 CDS YP_002330206.1 215487775 7064375 2786686..2787813 1 NC_011601.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2787813 dapE 7064375 dapE Escherichia coli O127:H6 str. E2348/69 succinyl-diaminopimelate desuccinylase YP_002330206.1 2786686 D 574521 CDS YP_002330207.1 215487776 7065223 2787841..2788041 1 NC_011601.1 hypothetical protein 2788041 ypfN 7065223 ypfN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330207.1 2787841 D 574521 CDS YP_002330208.1 215487777 7061243 complement(2788122..2788820) 1 NC_011601.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase 2788820 ypfH 7061243 ypfH Escherichia coli O127:H6 str. E2348/69 esterase YP_002330208.1 2788122 R 574521 CDS YP_002330209.1 215487778 7061240 complement(2788894..2790909) 1 NC_011601.1 hydrolase 2790909 ypfI 7061240 ypfI Escherichia coli O127:H6 str. E2348/69 hydrolase YP_002330209.1 2788894 R 574521 CDS YP_002330210.1 215487779 7061241 complement(2790924..2791787) 1 NC_011601.1 hypothetical protein 2791787 ypfJ 7061241 ypfJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330210.1 2790924 R 574521 CDS YP_002330211.1 215487780 7061242 complement(2791955..2792668) 1 NC_011601.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 2792668 purC 7061242 purC Escherichia coli O127:H6 str. E2348/69 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_002330211.1 2791955 R 574521 CDS YP_002330212.1 215487781 7063913 complement(2792881..2793915) 1 NC_011601.1 lipoprotein 2793915 nlpB 7063913 nlpB Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002330212.1 2792881 R 574521 CDS YP_002330213.1 215487782 7065401 complement(2793932..2794810) 1 NC_011601.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2794810 dapA 7065401 dapA Escherichia coli O127:H6 str. E2348/69 dihydrodipicolinate synthase YP_002330213.1 2793932 R 574521 CDS YP_002330214.1 215487783 7065220 2794956..2795528 1 NC_011601.1 negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2795528 gcvR 7065220 gcvR Escherichia coli O127:H6 str. E2348/69 glycine cleavage system transcriptional repressor YP_002330214.1 2794956 D 574521 CDS YP_002330215.1 215487784 7061645 2795528..2795998 1 NC_011601.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2795998 bcp 7061645 bcp Escherichia coli O127:H6 str. E2348/69 thioredoxin-dependent thiol peroxidase YP_002330215.1 2795528 D 574521 CDS YP_002330216.1 215487785 7062497 complement(2796097..2797158) 1 NC_011601.1 hypothetical protein 2797158 yfgO 7062497 yfgO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330216.1 2796097 R 574521 CDS YP_002330217.1 215487786 7064386 2797371..2798834 1 NC_011601.1 peptidase 2798834 yfgC 7064386 yfgC Escherichia coli O127:H6 str. E2348/69 peptidase YP_002330217.1 2797371 D 574521 CDS YP_002330218.1 215487787 7064378 2798855..2799214 1 NC_011601.1 oxidoreductase 2799214 yfgD 7064378 yfgD Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002330218.1 2798855 D 574521 CDS YP_002330219.1 215487788 7064379 complement(2799352..2800098) 1 NC_011601.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 2800098 hda 7064379 hda Escherichia coli O127:H6 str. E2348/69 DNA replication initiation factor YP_002330219.1 2799352 R 574521 CDS YP_002330220.1 215487789 7064284 complement(2800148..2801437) 1 NC_011601.1 uracil transporter 2801437 uraA 7064284 uraA Escherichia coli O127:H6 str. E2348/69 uracil transporter YP_002330220.1 2800148 R 574521 CDS YP_002330221.1 215487790 7062329 complement(2801523..2802149) 1 NC_011601.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 2802149 upp 7062329 upp Escherichia coli O127:H6 str. E2348/69 uracil phosphoribosyltransferase YP_002330221.1 2801523 R 574521 CDS YP_002330222.1 215487791 7062328 2802474..2803511 1 NC_011601.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2803511 purM 7062328 purM Escherichia coli O127:H6 str. E2348/69 phosphoribosylaminoimidazole synthetase YP_002330222.1 2802474 D 574521 CDS YP_002330223.1 215487792 7063920 2803511..2804149 1 NC_011601.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2804149 purN 7063920 purN Escherichia coli O127:H6 str. E2348/69 phosphoribosylglycinamide formyltransferase YP_002330223.1 2803511 D 574521 CDS YP_002330224.1 215487793 7063921 2804321..2806387 1 NC_011601.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2806387 ppk 7063921 ppk Escherichia coli O127:H6 str. E2348/69 polyphosphate kinase YP_002330224.1 2804321 D 574521 CDS YP_002330225.1 215487794 7061274 2806392..2807933 1 NC_011601.1 exopolyphosphatase 2807933 ppx 7061274 ppx Escherichia coli O127:H6 str. E2348/69 exopolyphosphatase YP_002330225.1 2806392 D 574521 CDS YP_002330226.1 215487795 7061279 complement(2807972..2810215) 1 NC_011601.1 hypothetical protein 2810215 yfgF 7061279 yfgF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330226.1 2807972 R 574521 CDS YP_002330227.1 215487796 7064380 2810567..2810758 1 NC_011601.1 hypothetical protein 2810758 yfgG 7064380 yfgG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330227.1 2810567 D 574521 CDS YP_002330228.1 215487797 7064381 2811072..2811587 1 NC_011601.1 outer membrane lipoprotein 2811587 yfgH 7064381 yfgH Escherichia coli O127:H6 str. E2348/69 outer membrane lipoprotein YP_002330228.1 2811072 D 574521 CDS YP_002330229.1 215487798 7064382 2811603..2812142 1 NC_011601.1 hypothetical protein 2812142 yfgI 7064382 yfgI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330229.1 2811603 D 574521 CDS YP_002330230.1 215487799 7061162 complement(2812360..2812842) 1 NC_011601.1 endopeptidase 2812842 7061162 E2348C_2732 Escherichia coli O127:H6 str. E2348/69 endopeptidase YP_002330230.1 2812360 R 574521 CDS YP_002330231.1 215487800 7065464 complement(2812368..2812643) 1 NC_011601.1 lipoprotein precursor 2812643 7065464 E2348C_2733 Escherichia coli O127:H6 str. E2348/69 lipoprotein precursor YP_002330231.1 2812368 R 574521 CDS YP_002330232.1 215487801 7065465 complement(2812839..2813465) 1 NC_011601.1 endolysin 2813465 7065465 E2348C_2734 Escherichia coli O127:H6 str. E2348/69 endolysin YP_002330232.1 2812839 R 574521 CDS YP_002330233.1 215487802 7065466 complement(2813455..2813763) 1 NC_011601.1 holin protein 2813763 7065466 E2348C_2735 Escherichia coli O127:H6 str. E2348/69 holin protein YP_002330233.1 2813455 R 574521 CDS YP_002330234.1 215487803 7065467 complement(2813750..2814154) 1 NC_011601.1 membrane protein 2814154 7065467 E2348C_2736 Escherichia coli O127:H6 str. E2348/69 membrane protein YP_002330234.1 2813750 R 574521 CDS YP_002330235.1 215487804 7065468 2814351..2815358 1 NC_011601.1 hypothetical protein 2815358 7065468 E2348C_2737 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330235.1 2814351 D 574521 CDS YP_002330236.1 215487805 7065469 2815452..2816525 1 NC_011601.1 acyltransferase 2816525 7065469 E2348C_2738 Escherichia coli O127:H6 str. E2348/69 acyltransferase YP_002330236.1 2815452 D 574521 CDS YP_002330237.1 215487806 7065470 complement(2816555..2819242) 1 NC_011601.1 tail fiber protein 2819242 7065470 E2348C_2739 Escherichia coli O127:H6 str. E2348/69 tail fiber protein YP_002330237.1 2816555 R 574521 CDS YP_002330238.1 215487807 7065471 2819441..2819701 1 NC_011601.1 hypothetical protein 2819701 7065471 E2348C_2740 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330238.1 2819441 D 574521 CDS YP_002330239.1 215487808 7065472 complement(2819902..2822376) 1 NC_011601.1 hypothetical protein 2822376 7065472 E2348C_2741 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330239.1 2819902 R 574521 CDS YP_002330240.1 215487809 7065473 complement(2822381..2824183) 1 NC_011601.1 hypothetical protein 2824183 7065473 E2348C_2742 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330240.1 2822381 R 574521 CDS YP_002330241.1 215487810 7065474 complement(2824180..2826690) 1 NC_011601.1 hypothetical protein 2826690 7065474 E2348C_2743 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330241.1 2824180 R 574521 CDS YP_002330242.1 215487811 7065475 complement(2826703..2827245) 1 NC_011601.1 hypothetical protein 2827245 7065475 E2348C_2744 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330242.1 2826703 R 574521 CDS YP_002330243.1 215487812 7065476 complement(2827245..2827709) 1 NC_011601.1 hypothetical protein 2827709 7065476 E2348C_2745 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330243.1 2827245 R 574521 CDS YP_002330244.1 215487813 7065477 complement(2827709..2830186) 1 NC_011601.1 hypothetical protein 2830186 7065477 E2348C_2746 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330244.1 2827709 R 574521 CDS YP_002330245.1 215487814 7065478 complement(2830186..2830791) 1 NC_011601.1 hypothetical protein 2830791 7065478 E2348C_2747 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330245.1 2830186 R 574521 CDS YP_002330246.1 215487815 7065479 complement(2830791..2831114) 1 NC_011601.1 hypothetical protein 2831114 7065479 E2348C_2748 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330246.1 2830791 R 574521 CDS YP_002330247.1 215487816 7065480 complement(2831166..2831546) 1 NC_011601.1 hypothetical protein 2831546 7065480 E2348C_2749 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330247.1 2831166 R 574521 CDS YP_002330248.1 215487817 7065481 complement(2831557..2831997) 1 NC_011601.1 hypothetical protein 2831997 7065481 E2348C_2750 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330248.1 2831557 R 574521 CDS YP_002330249.1 215487818 7065482 complement(2832049..2833035) 1 NC_011601.1 hypothetical protein 2833035 7065482 E2348C_2751 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330249.1 2832049 R 574521 CDS YP_002330250.1 215487819 7065483 complement(2833050..2833760) 1 NC_011601.1 endoprotease 2833760 7065483 E2348C_2752 Escherichia coli O127:H6 str. E2348/69 endoprotease YP_002330250.1 2833050 R 574521 CDS YP_002330251.1 215487820 7065484 complement(2833775..2834320) 1 NC_011601.1 protease 2834320 7065484 E2348C_2753 Escherichia coli O127:H6 str. E2348/69 protease YP_002330251.1 2833775 R 574521 CDS YP_002330252.1 215487821 7065485 complement(2834317..2834616) 1 NC_011601.1 hypothetical protein 2834616 7065485 E2348C_2754 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330252.1 2834317 R 574521 CDS YP_002330253.1 215487822 7065486 complement(2834613..2836283) 1 NC_011601.1 phage head-tail connector protein 2836283 7065486 E2348C_2755 Escherichia coli O127:H6 str. E2348/69 phage head-tail connector protein YP_002330253.1 2834613 R 574521 CDS YP_002330254.1 215487823 7065487 complement(2836298..2836504) 1 NC_011601.1 hypothetical protein 2836504 7065487 E2348C_2756 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330254.1 2836298 R 574521 CDS YP_002330255.1 215487824 7061151 2837376..2837807 1 NC_011601.1 hypothetical protein 2837807 7061151 E2348C_2757 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330255.1 2837376 D 574521 CDS YP_002330256.1 215487825 7065489 complement(2837851..2839332) 1 NC_011601.1 terminase large subunit 2839332 7065489 E2348C_2758 Escherichia coli O127:H6 str. E2348/69 terminase large subunit YP_002330256.1 2837851 R 574521 CDS YP_002330257.1 215487826 7065490 complement(2839329..2839922) 1 NC_011601.1 terminase, small subunit 2839922 7065490 E2348C_2759 Escherichia coli O127:H6 str. E2348/69 terminase, small subunit YP_002330257.1 2839329 R 574521 CDS YP_002330258.1 215487827 7065491 complement(2840026..2840364) 1 NC_011601.1 hypothetical protein 2840364 7065491 E2348C_2760 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330258.1 2840026 R 574521 CDS YP_002330259.1 215487828 7065492 complement(2840479..2840901) 1 NC_011601.1 hypothetical protein 2840901 7065492 E2348C_2761 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330259.1 2840479 R 574521 CDS YP_002330260.1 215487829 7065493 complement(2840898..2841194) 1 NC_011601.1 hypothetical protein 2841194 7065493 E2348C_2762 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330260.1 2840898 R 574521 CDS YP_002330261.1 215487830 7065494 complement(2841205..2841411) 1 NC_011601.1 hypothetical protein 2841411 7065494 E2348C_2763 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330261.1 2841205 R 574521 CDS YP_002330262.1 215487831 7065495 complement(2841377..2841643) 1 NC_011601.1 hypothetical protein 2841643 7065495 E2348C_2764 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330262.1 2841377 R 574521 CDS YP_002330263.1 215487832 7065496 complement(2841662..2841964) 1 NC_011601.1 hypothetical protein 2841964 7065496 E2348C_2765 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330263.1 2841662 R 574521 CDS YP_002330264.1 215487833 7065497 complement(2842026..2842367) 1 NC_011601.1 hypothetical protein 2842367 7065497 E2348C_2766 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330264.1 2842026 R 574521 CDS YP_002330265.1 215487834 7065498 complement(2842485..2843225) 1 NC_011601.1 replication protein 2843225 7065498 E2348C_2767 Escherichia coli O127:H6 str. E2348/69 replication protein YP_002330265.1 2842485 R 574521 CDS YP_002330266.1 215487835 7065499 complement(2843267..2844073) 1 NC_011601.1 primosomal protein 2844073 7065499 E2348C_2768 Escherichia coli O127:H6 str. E2348/69 primosomal protein YP_002330266.1 2843267 R 574521 CDS YP_002330267.1 215487836 7065500 complement(2844089..2844289) 1 NC_011601.1 hypothetical protein 2844289 7065500 E2348C_2769 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330267.1 2844089 R 574521 CDS YP_002330268.1 215487837 7065501 complement(2844437..2844670) 1 NC_011601.1 hypothetical protein 2844670 7065501 E2348C_2770 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330268.1 2844437 R 574521 CDS YP_002330269.1 215487838 7065502 2844826..2845422 1 NC_011601.1 repressor protein 2845422 7065502 E2348C_2771 Escherichia coli O127:H6 str. E2348/69 repressor protein YP_002330269.1 2844826 D 574521 CDS YP_002330270.1 215487839 7065503 2845647..2845796 1 NC_011601.1 hypothetical protein 2845796 7065503 E2348C_2772 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330270.1 2845647 D 574521 CDS YP_002330271.1 215487840 7065504 2845793..2846752 1 NC_011601.1 hypothetical protein 2846752 7065504 E2348C_2773 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330271.1 2845793 D 574521 CDS YP_002330272.1 215487841 7065505 2846760..2847062 1 NC_011601.1 hypothetical protein 2847062 7065505 E2348C_2774 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330272.1 2846760 D 574521 CDS YP_002330273.1 215487842 7065506 2847059..2847880 1 NC_011601.1 exonuclease VIII/RecE-like protein 2847880 7065506 E2348C_2775 Escherichia coli O127:H6 str. E2348/69 exonuclease VIII/RecE-like protein YP_002330273.1 2847059 D 574521 CDS YP_002330274.1 215487843 7065507 2847877..2848758 1 NC_011601.1 RecT family protein 2848758 7065507 E2348C_2776 Escherichia coli O127:H6 str. E2348/69 RecT family protein YP_002330274.1 2847877 D 574521 CDS YP_002330275.1 215487844 7065508 2848805..2849053 1 NC_011601.1 transcriptional regulator, AlpA family 2849053 7065508 E2348C_2777 Escherichia coli O127:H6 str. E2348/69 transcriptional regulator, AlpA family YP_002330275.1 2848805 D 574521 CDS YP_002330276.1 215487845 7065509 2849163..2849462 1 NC_011601.1 hypothetical protein 2849462 7065509 E2348C_2778 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330276.1 2849163 D 574521 CDS YP_002330277.1 215487846 7065510 2849610..2850323 1 NC_011601.1 hypothetical protein 2850323 7065510 E2348C_2779 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330277.1 2849610 D 574521 CDS YP_002330278.1 215487847 7065511 2850320..2850913 1 NC_011601.1 adenine methylase 2850913 7065511 E2348C_2780 Escherichia coli O127:H6 str. E2348/69 adenine methylase YP_002330278.1 2850320 D 574521 CDS YP_002330279.1 215487848 7065512 complement(2851086..2852339) 1 NC_011601.1 integrase 2852339 7065512 E2348C_2781 Escherichia coli O127:H6 str. E2348/69 integrase YP_002330279.1 2851086 R 574521 CDS YP_002330280.1 215487849 7065513 complement(2852532..2854109) 1 NC_011601.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 2854109 guaA 7065513 guaA Escherichia coli O127:H6 str. E2348/69 GMP synthase YP_002330280.1 2852532 R 574521 CDS YP_002330281.1 215487850 7064270 complement(2854178..2855644) 1 NC_011601.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2855644 guaB 7064270 guaB Escherichia coli O127:H6 str. E2348/69 inosine 5'-monophosphate dehydrogenase YP_002330281.1 2854178 R 574521 CDS YP_002330282.1 215487851 7064271 2855806..2857179 1 NC_011601.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2857179 xseA 7064271 xseA Escherichia coli O127:H6 str. E2348/69 exodeoxyribonuclease VII large subunit YP_002330282.1 2855806 D 574521 CDS YP_002330283.1 215487852 7064958 complement(2857508..2859790) 1 NC_011601.1 RatA-like protein 2859790 7064958 E2348C_2785 Escherichia coli O127:H6 str. E2348/69 RatA-like protein YP_002330283.1 2857508 R 574521 CDS YP_002330284.1 215487853 7065514 complement(2859900..2860856) 1 NC_011601.1 outer membrane protein 2860856 7065514 E2348C_2786 Escherichia coli O127:H6 str. E2348/69 outer membrane protein YP_002330284.1 2859900 R 574521 CDS YP_002330285.1 215487854 7065515 complement(2860904..2863039) 1 NC_011601.1 intimin-like protein 2863039 7065515 E2348C_2787 Escherichia coli O127:H6 str. E2348/69 intimin-like protein YP_002330285.1 2860904 R 574521 CDS YP_002330286.1 215487855 7065516 complement(2863959..2864558) 1 NC_011601.1 hypothetical protein 2864558 7065516 E2348C_2788 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330286.1 2863959 R 574521 CDS YP_002330287.1 215487856 7065517 complement(2865065..2865724) 1 NC_011601.1 hypothetical protein 2865724 7065517 E2348C_2789 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330287.1 2865065 R 574521 CDS YP_002330288.1 215487857 7065518 complement(2865726..2866646) 1 NC_011601.1 hypothetical protein 2866646 7065518 E2348C_2790 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330288.1 2865726 R 574521 CDS YP_002330289.1 215487858 7065519 complement(2867992..2868990) 1 NC_011601.1 hypothetical protein 2868990 7065519 E2348C_2791 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330289.1 2867992 R 574521 CDS YP_002330290.1 215487859 7065520 complement(2869043..2869738) 1 NC_011601.1 hypothetical protein 2869738 7065520 E2348C_2792 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330290.1 2869043 R 574521 CDS YP_002330291.1 215487860 7065521 complement(2869825..2871087) 1 NC_011601.1 integrase 2871087 7065521 E2348C_2793 Escherichia coli O127:H6 str. E2348/69 integrase YP_002330291.1 2869825 R 574521 CDS YP_002330292.1 215487861 7065522 complement(2871313..2872785) 1 NC_011601.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 2872785 engA 7065522 engA Escherichia coli O127:H6 str. E2348/69 GTP-binding protein EngA YP_002330292.1 2871313 R 574521 CDS YP_002330293.1 215487862 7065012 complement(2872903..2874081) 1 NC_011601.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL 2874081 yfgL 7065012 yfgL Escherichia coli O127:H6 str. E2348/69 outer membrane protein assembly complex subunit YfgL YP_002330293.1 2872903 R 574521 CDS YP_002330294.1 215487863 7064384 complement(2874092..2874712) 1 NC_011601.1 hypothetical protein 2874712 yfgM 7064384 yfgM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330294.1 2874092 R 574521 CDS YP_002330295.1 215487864 7064385 complement(2874730..2876004) 1 NC_011601.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2876004 hisS 7064385 hisS Escherichia coli O127:H6 str. E2348/69 histidyl-tRNA synthetase YP_002330295.1 2874730 R 574521 CDS YP_002330296.1 215487865 7062758 complement(2876115..2877233) 1 NC_011601.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2877233 ispG 7062758 ispG Escherichia coli O127:H6 str. E2348/69 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_002330296.1 2876115 R 574521 CDS YP_002330297.1 215487866 7063556 complement(2877260..2878267) 1 NC_011601.1 cytoskeletal protein RodZ 2878267 yfgA 7063556 yfgA Escherichia coli O127:H6 str. E2348/69 cytoskeletal protein RodZ YP_002330297.1 2877260 R 574521 CDS YP_002330298.1 215487867 7064376 complement(2878552..2879706) 1 NC_011601.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 2879706 yfgB 7064376 yfgB Escherichia coli O127:H6 str. E2348/69 ribosomal RNA large subunit methyltransferase N YP_002330298.1 2878552 R 574521 CDS YP_002330299.1 215487868 7064377 complement(2879856..2880287) 1 NC_011601.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2880287 ndk 7064377 ndk Escherichia coli O127:H6 str. E2348/69 nucleoside diphosphate kinase YP_002330299.1 2879856 R 574521 CDS YP_002330300.1 215487869 7065377 complement(2880436..2882748) 1 NC_011601.1 penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C 2882748 pbpC 7065377 pbpC Escherichia coli O127:H6 str. E2348/69 penicillin-binding protein 1C YP_002330300.1 2880436 R 574521 CDS YP_002330301.1 215487870 7062913 complement(2882749..2887710) 1 NC_011601.1 hypothetical protein 2887710 yfhM 7062913 yfhM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330301.1 2882749 R 574521 CDS YP_002330302.1 215487871 7064392 2887917..2888762 1 NC_011601.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2888762 sseA 7064392 sseA Escherichia coli O127:H6 str. E2348/69 3-mercaptopyruvate sulfurtransferase YP_002330302.1 2887917 D 574521 CDS YP_002330303.1 215487872 7064598 complement(2889255..2890031) 1 NC_011601.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB 2890031 sseB 7064598 sseB Escherichia coli O127:H6 str. E2348/69 enhanced serine sensitivity protein SseB YP_002330303.1 2889255 R 574521 CDS YP_002330304.1 215487873 7062763 complement(2890174..2891457) 1 NC_011601.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase 2891457 pepB 7062763 pepB Escherichia coli O127:H6 str. E2348/69 aminopeptidase YP_002330304.1 2890174 R 574521 CDS YP_002330305.1 215487874 7061179 complement(2891516..2891716) 1 NC_011601.1 hypothetical protein 2891716 iscX 7061179 iscX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330305.1 2891516 R 574521 CDS YP_002330306.1 215487875 7063550 complement(2891728..2892063) 1 NC_011601.1 [2Fe-2S] ferredoxin 2892063 fdx 7063550 fdx Escherichia coli O127:H6 str. E2348/69 [2Fe-2S] ferredoxin YP_002330306.1 2891728 R 574521 CDS YP_002330307.1 215487876 7062095 complement(2892065..2893915) 1 NC_011601.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 2893915 hscA 7062095 hscA Escherichia coli O127:H6 str. E2348/69 chaperone protein HscA YP_002330307.1 2892065 R 574521 CDS YP_002330308.1 215487877 7062180 complement(2893932..2894447) 1 NC_011601.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 2894447 hscB 7062180 hscB Escherichia coli O127:H6 str. E2348/69 co-chaperone HscB YP_002330308.1 2893932 R 574521 CDS YP_002330309.1 215487878 7062181 complement(2894543..2894866) 1 NC_011601.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein 2894866 iscA 7062181 iscA Escherichia coli O127:H6 str. E2348/69 iron-sulfur cluster assembly protein YP_002330309.1 2894543 R 574521 CDS YP_002330310.1 215487879 7063546 complement(2894883..2895269) 1 NC_011601.1 scaffold protein 2895269 iscU 7063546 iscU Escherichia coli O127:H6 str. E2348/69 scaffold protein YP_002330310.1 2894883 R 574521 CDS YP_002330311.1 215487880 7063549 complement(2895297..2896511) 1 NC_011601.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 2896511 iscS 7063549 iscS Escherichia coli O127:H6 str. E2348/69 cysteine desulfurase YP_002330311.1 2895297 R 574521 CDS YP_002330312.1 215487881 7063548 complement(2896623..2897111) 1 NC_011601.1 regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR 2897111 iscR 7063548 iscR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator IscR YP_002330312.1 2896623 R 574521 CDS YP_002330313.1 215487882 7063547 complement(2897381..2898121) 1 NC_011601.1 methyltransferase 2898121 trmJ 7063547 trmJ Escherichia coli O127:H6 str. E2348/69 methyltransferase YP_002330313.1 2897381 R 574521 CDS YP_002330314.1 215487883 7062245 2898240..2899043 1 NC_011601.1 inositol monophosphatase 2899043 suhB 7062245 suhB Escherichia coli O127:H6 str. E2348/69 inositol monophosphatase YP_002330314.1 2898240 D 574521 CDS YP_002330315.1 215487884 7061742 2899188..2900042 1 NC_011601.1 peptidase 2900042 yfhR 7061742 yfhR Escherichia coli O127:H6 str. E2348/69 peptidase YP_002330315.1 2899188 D 574521 CDS YP_002330316.1 215487885 7064393 2900233..2901513 1 NC_011601.1 stationary phase inducible protein CsiE 2901513 csiE 7064393 csiE Escherichia coli O127:H6 str. E2348/69 stationary phase inducible protein CsiE YP_002330316.1 2900233 D 574521 CDS YP_002330317.1 215487886 7062858 complement(2901505..2902644) 1 NC_011601.1 transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter 2902644 hcaT 7062858 hcaT Escherichia coli O127:H6 str. E2348/69 3-phenylpropionic acid transporter YP_002330317.1 2901505 R 574521 CDS YP_002330318.1 215487887 7064280 2902968..2903435 1 NC_011601.1 hypothetical protein 2903435 yphA 7064280 yphA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330318.1 2902968 D 574521 CDS YP_002330319.1 215487888 7061244 complement(2903595..2904467) 1 NC_011601.1 hypothetical protein 2904467 yphB 7061244 yphB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330319.1 2903595 R 574521 CDS YP_002330320.1 215487889 7061245 complement(2904479..2905540) 1 NC_011601.1 oxidoreductase, Zn-dependent and NAD(P)-binding 2905540 yphC 7061245 yphC Escherichia coli O127:H6 str. E2348/69 oxidoreductase, Zn-dependent and NAD(P)-binding YP_002330320.1 2904479 R 574521 CDS YP_002330321.1 215487890 7061246 complement(2905606..2906604) 1 NC_011601.1 sugar transporter subunit: membrane component of ABC superfamily 2906604 yphD 7061246 yphD Escherichia coli O127:H6 str. E2348/69 sugar transporter subunit: membrane component of ABC superfamily YP_002330321.1 2905606 R 574521 CDS YP_002330322.1 215487891 7061247 complement(2906629..2908140) 1 NC_011601.1 fused sugar transporter subunits of ABC superfamily: ATP-binding components 2908140 yphE 7061247 yphE Escherichia coli O127:H6 str. E2348/69 fused sugar transporter subunits of ABC superfamily: ATP-binding components YP_002330322.1 2906629 R 574521 CDS YP_002330323.1 215487892 7061248 complement(2908163..2909146) 1 NC_011601.1 sugar transporter subunit: periplasmic-binding component of ABC superfamily 2909146 yphF 7061248 yphF Escherichia coli O127:H6 str. E2348/69 sugar transporter subunit: periplasmic-binding component of ABC superfamily YP_002330323.1 2908163 R 574521 CDS YP_002330324.1 215487893 7061249 complement(2909243..2912524) 1 NC_011601.1 hypothetical protein 2912524 yphG 7061249 yphG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330324.1 2909243 R 574521 CDS YP_002330325.1 215487894 7061250 2912642..2913835 1 NC_011601.1 DNA-binding transcriptional regulator 2913835 yphH 7061250 yphH Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330325.1 2912642 D 574521 CDS YP_002330326.1 215487895 7061251 complement(2913899..2915152) 1 NC_011601.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 2915152 glyA 7061251 glyA Escherichia coli O127:H6 str. E2348/69 serine hydroxymethyltransferase YP_002330326.1 2913899 R 574521 CDS YP_002330327.1 215487896 7061720 2915480..2916670 1 NC_011601.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2916670 hmp 7061720 hmp Escherichia coli O127:H6 str. E2348/69 nitric oxide dioxygenase YP_002330327.1 2915480 D 574521 CDS YP_002330328.1 215487897 7062159 complement(2916715..2917053) 1 NC_011601.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 2917053 glnB 7062159 glnB Escherichia coli O127:H6 str. E2348/69 nitrogen regulatory protein P-II 1 YP_002330328.1 2916715 R 574521 CDS YP_002330329.1 215487898 7061677 complement(2917114..2918448) 1 NC_011601.1 DNA-binding response regulator in two-component system with QseE 2918448 qseF 7061677 qseF Escherichia coli O127:H6 str. E2348/69 DNA-binding response regulator in two-component system with QseE YP_002330329.1 2917114 R 574521 CDS YP_002330330.1 215487899 7063942 complement(2918438..2919151) 1 NC_011601.1 hypothetical protein 2919151 yfhG 7063942 yfhG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330330.1 2918438 R 574521 CDS YP_002330331.1 215487900 7064389 complement(2919316..2920743) 1 NC_011601.1 sensory kinase in two-component system with QseF 2920743 qseE 7064389 qseE Escherichia coli O127:H6 str. E2348/69 sensory kinase in two-component system with QseF YP_002330331.1 2919316 R 574521 CDS YP_002330332.1 215487901 7062759 complement(2921319..2925206) 1 NC_011601.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 2925206 purL 7062759 purL Escherichia coli O127:H6 str. E2348/69 phosphoribosylformylglycinamidine synthase YP_002330332.1 2921319 R 574521 CDS YP_002330333.1 215487902 7063919 2925603..2927021 1 NC_011601.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 2927021 yfhD 7063919 yfhD Escherichia coli O127:H6 str. E2348/69 transglycosylase YP_002330333.1 2925603 D 574521 CDS YP_002330334.1 215487903 7064388 complement(2927018..2927521) 1 NC_011601.1 tRNA-specific adenosine deaminase 2927521 tadA 7064388 tadA Escherichia coli O127:H6 str. E2348/69 tRNA-specific adenosine deaminase YP_002330334.1 2927018 R 574521 CDS YP_002330335.1 215487904 7061747 complement(2927579..2928214) 1 NC_011601.1 hypothetical protein 2928214 yfhB 7061747 yfhB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330335.1 2927579 R 574521 CDS YP_002330336.1 215487905 7064387 2928423..2929271 1 NC_011601.1 DNA-binding transcriptional regulator 2929271 yfhH 7064387 yfhH Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330336.1 2928423 D 574521 CDS YP_002330337.1 215487906 7064390 2929327..2929587 1 NC_011601.1 (4Fe-4S)-binding protein 2929587 yfhL 7064390 yfhL Escherichia coli O127:H6 str. E2348/69 (4Fe-4S)-binding protein YP_002330337.1 2929327 D 574521 CDS YP_002330338.1 215487907 7064600 complement(2930282..2930662) 1 NC_011601.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2930662 acpS 7064600 acpS Escherichia coli O127:H6 str. E2348/69 4'-phosphopantetheinyl transferase YP_002330338.1 2930282 R 574521 CDS YP_002330339.1 215487908 7062394 complement(2930662..2931393) 1 NC_011601.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 2931393 pdxJ 7062394 pdxJ Escherichia coli O127:H6 str. E2348/69 pyridoxine 5'-phosphate synthase YP_002330339.1 2930662 R 574521 CDS YP_002330340.1 215487909 7062942 complement(2931405..2932133) 1 NC_011601.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 2932133 recO 7062942 recO Escherichia coli O127:H6 str. E2348/69 DNA repair protein RecO YP_002330340.1 2931405 R 574521 CDS YP_002330341.1 215487910 7063983 complement(2932145..2933050) 1 NC_011601.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 2933050 era 7063983 era Escherichia coli O127:H6 str. E2348/69 GTP-binding protein Era YP_002330341.1 2932145 R 574521 CDS YP_002330342.1 215487911 7063865 complement(2933047..2933727) 1 NC_011601.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2933727 rnc 7063865 rnc Escherichia coli O127:H6 str. E2348/69 ribonuclease III YP_002330342.1 2933047 R 574521 CDS YP_002330343.1 215487912 7060848 complement(2933998..2934972) 1 NC_011601.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I 2934972 lepB 7060848 lepB Escherichia coli O127:H6 str. E2348/69 signal peptidase I YP_002330343.1 2933998 R 574521 CDS YP_002330344.1 215487913 7061519 complement(2934988..2936787) 1 NC_011601.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 2936787 lepA 7061519 lepA Escherichia coli O127:H6 str. E2348/69 GTP-binding protein LepA YP_002330344.1 2934988 R 574521 CDS YP_002330345.1 215487914 7061518 complement(2936985..2937464) 1 NC_011601.1 involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC 2937464 rseC 7061518 rseC Escherichia coli O127:H6 str. E2348/69 SoxR reducing system protein RseC YP_002330345.1 2936985 R 574521 CDS YP_002330346.1 215487915 7064552 complement(2937461..2938417) 1 NC_011601.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 2938417 rseB 7064552 rseB Escherichia coli O127:H6 str. E2348/69 periplasmic negative regulator of sigmaE YP_002330346.1 2937461 R 574521 CDS YP_002330347.1 215487916 7064551 complement(2938417..2939067) 1 NC_011601.1 anti-RNA polymerase sigma factor SigE 2939067 rseA 7064551 rseA Escherichia coli O127:H6 str. E2348/69 anti-RNA polymerase sigma factor SigE YP_002330347.1 2938417 R 574521 CDS YP_002330348.1 215487917 7064550 complement(2939100..2939675) 1 NC_011601.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 2939675 rpoE 7064550 rpoE Escherichia coli O127:H6 str. E2348/69 RNA polymerase sigma factor RpoE YP_002330348.1 2939100 R 574521 CDS YP_002330349.1 215487918 7061867 2940083..2941705 1 NC_011601.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2941705 nadB 7061867 nadB Escherichia coli O127:H6 str. E2348/69 L-aspartate oxidase YP_002330349.1 2940083 D 574521 CDS YP_002330350.1 215487919 7060905 complement(2941690..2942427) 1 NC_011601.1 S-adenosyl-L-methionine-dependent methyltransferase 2942427 yfiC 7060905 yfiC Escherichia coli O127:H6 str. E2348/69 S-adenosyl-L-methionine-dependent methyltransferase YP_002330350.1 2941690 R 574521 CDS YP_002330351.1 215487920 7064395 2942559..2943893 1 NC_011601.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2943893 srmB 7064395 srmB Escherichia coli O127:H6 str. E2348/69 ATP-dependent RNA helicase SrmB YP_002330351.1 2942559 D 574521 CDS YP_002330352.1 215487921 7062754 complement(2943926..2944807) 1 NC_011601.1 DNA-binding transcriptional regulator 2944807 yfiE 7062754 yfiE Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330352.1 2943926 R 574521 CDS YP_002330353.1 215487922 7065079 complement(2945552..2945935) 1 NC_011601.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 2945935 yfiD 7065079 yfiD Escherichia coli O127:H6 str. E2348/69 autonomous glycyl radical cofactor GrcA YP_002330353.1 2945552 R 574521 CDS YP_002330354.1 215487923 7064396 2946240..2946929 1 NC_011601.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2946929 ung 7064396 ung Escherichia coli O127:H6 str. E2348/69 uracil-DNA glycosylase YP_002330354.1 2946240 D 574521 CDS YP_002330355.1 215487924 7062326 complement(2946977..2948014) 1 NC_011601.1 methyltransferase 2948014 yfiF 7062326 yfiF Escherichia coli O127:H6 str. E2348/69 methyltransferase YP_002330355.1 2946977 R 574521 CDS YP_002330356.1 215487925 7064398 2948221..2948640 1 NC_011601.1 thioredoxin 2 2948640 trxC 7064398 trxC Escherichia coli O127:H6 str. E2348/69 thioredoxin 2 YP_002330356.1 2948221 D 574521 CDS YP_002330357.1 215487926 7062269 2948709..2949407 1 NC_011601.1 hypothetical protein 2949407 yfiP 7062269 yfiP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330357.1 2948709 D 574521 CDS YP_002330358.1 215487927 7064403 2949439..2952099 1 NC_011601.1 fused acyl-CoA synthetase: NAD(P)-binding subunit/ATP-binding subunit 2952099 yfiQ 7064403 yfiQ Escherichia coli O127:H6 str. E2348/69 fused acyl-CoA synthetase: NAD(P)-binding subunit/ATP-binding subunit YP_002330358.1 2949439 D 574521 CDS YP_002330359.1 215487928 7064404 2952213..2953568 1 NC_011601.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2953568 pssA 7064404 pssA Escherichia coli O127:H6 str. E2348/69 phosphatidylserine synthase YP_002330359.1 2952213 D 574521 CDS YP_002330360.1 215487929 7061328 2953665..2953937 1 NC_011601.1 hypothetical protein 2953937 yfiM 7061328 yfiM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330360.1 2953665 D 574521 CDS YP_002330361.1 215487930 7064401 complement(2953934..2955232) 1 NC_011601.1 alpha-ketoglutarate transporter 2955232 kgtP 7064401 kgtP Escherichia coli O127:H6 str. E2348/69 alpha-ketoglutarate transporter YP_002330361.1 2953934 R 574521 CDS YP_002330362.1 215487931 7064547 complement(2962514..2965087) 1 NC_011601.1 protein disaggregation chaperone 2965087 clpB 7064547 clpB Escherichia coli O127:H6 str. E2348/69 protein disaggregation chaperone YP_002330362.1 2962514 R 574521 CDS YP_002330363.1 215487932 7064601 complement(2965217..2965948) 1 NC_011601.1 hypothetical protein 2965948 yfiH 7064601 yfiH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330363.1 2965217 R 574521 CDS YP_002330364.1 215487933 7064399 complement(2965945..2966925) 1 NC_011601.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 2966925 rluD 7064399 rluD Escherichia coli O127:H6 str. E2348/69 23S rRNA pseudouridine synthase D YP_002330364.1 2965945 R 574521 CDS YP_002330365.1 215487934 7060841 2967060..2967797 1 NC_011601.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2967797 yfiO 7060841 yfiO Escherichia coli O127:H6 str. E2348/69 outer membrane protein assembly complex subunit YfiO YP_002330365.1 2967060 D 574521 CDS YP_002330366.1 215487935 7065524 2969168..2969509 1 NC_011601.1 associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2969509 raiA 7065524 raiA Escherichia coli O127:H6 str. E2348/69 translation inhibitor protein RaiA YP_002330366.1 2969168 D 574521 CDS YP_002330368.1 215487937 7060721 2969759..2970919 1 NC_011601.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2970919 pheA 7060721 pheA Escherichia coli O127:H6 str. E2348/69 bifunctional chorismate mutase/prephenate dehydratase YP_002330368.1 2969759 D 574521 CDS YP_002330369.1 215487938 7060720 complement(2970962..2972083) 1 NC_011601.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 2972083 tyrA 7060720 tyrA Escherichia coli O127:H6 str. E2348/69 bifunctional chorismate mutase/prephenate dehydrogenase YP_002330369.1 2970962 R 574521 CDS YP_002330370.1 215487939 7062283 complement(2972094..2973164) 1 NC_011601.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 2973164 aroF 7062283 aroF Escherichia coli O127:H6 str. E2348/69 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002330370.1 2972094 R 574521 CDS YP_002330371.1 215487940 7061394 2973378..2973740 1 NC_011601.1 hypothetical protein 2973740 yfiL 7061394 yfiL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330371.1 2973378 D 574521 CDS YP_002330372.1 215487941 7064400 2973888..2974406 1 NC_011601.1 hypothetical protein 2974406 yfiR 7064400 yfiR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330372.1 2973888 D 574521 CDS YP_002330373.1 215487942 7064405 2974396..2975622 1 NC_011601.1 hypothetical protein 2975622 yfiN 7064405 yfiN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330373.1 2974396 D 574521 CDS YP_002330374.1 215487943 7064402 2975638..2976120 1 NC_011601.1 outer membrane lipoprotein 2976120 yfiB 7064402 yfiB Escherichia coli O127:H6 str. E2348/69 outer membrane lipoprotein YP_002330374.1 2975638 D 574521 CDS YP_002330375.1 215487944 7061163 complement(2976324..2977253) 1 NC_011601.1 hypothetical protein 2977253 7061163 E2348C_2880 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330375.1 2976324 R 574521 CDS YP_002330376.1 215487945 7065527 2978079..2978681 1 NC_011601.1 tail fibre assembly protein 2978681 7065527 E2348C_2883 Escherichia coli O127:H6 str. E2348/69 tail fibre assembly protein YP_002330376.1 2978079 D 574521 CDS YP_002330377.1 215487946 7065528 complement(2978653..2979093) 1 NC_011601.1 hypothetical protein 2979093 7065528 E2348C_2884 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330377.1 2978653 R 574521 CDS YP_002330378.1 215487947 7065530 2979534..2980112 1 NC_011601.1 DNA-invertase 2980112 7065530 E2348C_2886 Escherichia coli O127:H6 str. E2348/69 DNA-invertase YP_002330378.1 2979534 D 574521 CDS YP_002330379.1 215487948 7065531 2980177..2981364 1 NC_011601.1 tail sheath protein 2981364 7065531 E2348C_2887 Escherichia coli O127:H6 str. E2348/69 tail sheath protein YP_002330379.1 2980177 D 574521 CDS YP_002330380.1 215487949 7062544 2981377..2981895 1 NC_011601.1 tail tube protein 2981895 7062544 E2348C_2888 Escherichia coli O127:H6 str. E2348/69 tail tube protein YP_002330380.1 2981377 D 574521 CDS YP_002330381.1 215487950 7062545 2981958..2982230 1 NC_011601.1 tail protein 2982230 7062545 E2348C_2889 Escherichia coli O127:H6 str. E2348/69 tail protein YP_002330381.1 2981958 D 574521 CDS YP_002330382.1 215487951 7062546 2982384..2984813 1 NC_011601.1 tail length tape measure protein 2984813 7062546 E2348C_2890 Escherichia coli O127:H6 str. E2348/69 tail length tape measure protein YP_002330382.1 2982384 D 574521 CDS YP_002330383.1 215487952 7062547 2984825..2985289 1 NC_011601.1 tail fiber protein 2985289 7062547 E2348C_2891 Escherichia coli O127:H6 str. E2348/69 tail fiber protein YP_002330383.1 2984825 D 574521 CDS YP_002330384.1 215487953 7062548 2985292..2986464 1 NC_011601.1 late gene regulator 2986464 7062548 E2348C_2892 Escherichia coli O127:H6 str. E2348/69 late gene regulator YP_002330384.1 2985292 D 574521 CDS YP_002330385.1 215487954 7062549 2986541..2986759 1 NC_011601.1 DNA-binding transcriptional regulator 2986759 7062549 E2348C_2893 Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330385.1 2986541 D 574521 CDS YP_002330386.1 215487955 7062550 complement(2986797..2987519) 1 NC_011601.1 hypothetical protein 2987519 7062550 E2348C_2894 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330386.1 2986797 R 574521 CDS YP_002330387.1 215487956 7062551 complement(2987725..2988072) 1 NC_011601.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2988072 rplS 7062551 rplS Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L19 YP_002330387.1 2987725 R 574521 CDS YP_002330388.1 215487957 7061846 complement(2988114..2988881) 1 NC_011601.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2988881 trmD 7061846 trmD Escherichia coli O127:H6 str. E2348/69 tRNA (guanine-N(1)-)-methyltransferase YP_002330388.1 2988114 R 574521 CDS YP_002330389.1 215487958 7062242 complement(2988912..2989460) 1 NC_011601.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2989460 rimM 7062242 rimM Escherichia coli O127:H6 str. E2348/69 16S rRNA-processing protein RimM YP_002330389.1 2988912 R 574521 CDS YP_002330390.1 215487959 7060831 complement(2989479..2989727) 1 NC_011601.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2989727 rpsP 7060831 rpsP Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S16 YP_002330390.1 2989479 R 574521 CDS YP_002330391.1 215487960 7061888 complement(2989864..2991225) 1 NC_011601.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein 2991225 ffh 7061888 ffh Escherichia coli O127:H6 str. E2348/69 signal recognition particle protein YP_002330391.1 2989864 R 574521 CDS YP_002330392.1 215487961 7062107 2991317..2992183 1 NC_011601.1 hypothetical protein 2992183 ypjD 7062107 ypjD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330392.1 2991317 D 574521 CDS YP_002330393.1 215487962 7061252 2992228..2993490 1 NC_011601.1 hypothetical protein 2993490 yfjD 7061252 yfjD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330393.1 2992228 D 574521 CDS YP_002330394.1 215487963 7064406 complement(2993545..2994138) 1 NC_011601.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 2994138 grpE 7064406 grpE Escherichia coli O127:H6 str. E2348/69 heat shock protein GrpE YP_002330394.1 2993545 R 574521 CDS YP_002330395.1 215487964 7064245 2994261..2995139 1 NC_011601.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2995139 ppnK 7064245 ppnK Escherichia coli O127:H6 str. E2348/69 inorganic polyphosphate/ATP-NAD kinase YP_002330395.1 2994261 D 574521 CDS YP_002330396.1 215487965 7060909 2995225..2996886 1 NC_011601.1 recombination and repair protein 2996886 recN 7060909 recN Escherichia coli O127:H6 str. E2348/69 recombination and repair protein YP_002330396.1 2995225 D 574521 CDS YP_002330397.1 215487966 7063982 2997035..2997376 1 NC_011601.1 hypothetical protein 2997376 smpA 7063982 smpA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330397.1 2997035 D 574521 CDS YP_002330398.1 215487967 7062729 complement(2997438..2997728) 1 NC_011601.1 hypothetical protein 2997728 yfjF 7062729 yfjF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330398.1 2997438 R 574521 CDS YP_002330399.1 215487968 7064407 complement(2997718..2998194) 1 NC_011601.1 hypothetical protein 2998194 yfjG 7064407 yfjG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330399.1 2997718 R 574521 CDS YP_002330400.1 215487969 7064408 2998326..2998808 1 NC_011601.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2998808 smpB 7064408 smpB Escherichia coli O127:H6 str. E2348/69 SsrA-binding protein YP_002330400.1 2998326 D 574521 CDS YP_002330401.1 215487970 7062555 3003890..3004108 1 NC_011601.1 hypothetical protein 3004108 7062555 E2348C_2913 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330401.1 3003890 D 574521 CDS YP_002330402.1 215487971 7062556 3004369..3004740 1 NC_011601.1 hypothetical protein 3004740 7062556 E2348C_2914 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330402.1 3004369 D 574521 CDS YP_002330403.1 215487972 7062557 complement(3005494..3009411) 1 NC_011601.1 serine protease 3009411 espC 7062557 espC Escherichia coli O127:H6 str. E2348/69 serine protease YP_002330403.1 3005494 R 574521 CDS YP_002330404.1 215487973 7063879 complement(3009981..3011153) 1 NC_011601.1 T3SS secreted effector EspG-like protein 3011153 7063879 E2348C_2916 Escherichia coli O127:H6 str. E2348/69 T3SS secreted effector EspG-like protein YP_002330404.1 3009981 R 574521 CDS YP_002330405.1 215487974 7062558 complement(3011232..3011396) 1 NC_011601.1 hypothetical protein 3011396 7062558 E2348C_2917 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330405.1 3011232 R 574521 CDS YP_002330406.1 215487975 7062559 3011977..3012462 1 NC_011601.1 hypothetical protein 3012462 7062559 E2348C_2918 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330406.1 3011977 D 574521 CDS YP_002330407.1 215487976 7062560 3013615..3013785 1 NC_011601.1 hypothetical protein 3013785 7062560 E2348C_2919 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330407.1 3013615 D 574521 CDS YP_002330408.1 215487977 7062561 complement(3013792..3013992) 1 NC_011601.1 hypothetical protein 3013992 7062561 E2348C_2920 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330408.1 3013792 R 574521 CDS YP_002330409.1 215487978 7062562 3014161..3014541 1 NC_011601.1 hypothetical protein 3014541 7062562 E2348C_2921 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330409.1 3014161 D 574521 CDS YP_002330410.1 215487979 7062563 3014849..3015826 1 NC_011601.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 3015826 csiD 7062563 csiD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330410.1 3014849 D 574521 CDS YP_002330411.1 215487980 7062857 3015846..3017114 1 NC_011601.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 3017114 ihgO 7062857 ihgO Escherichia coli O127:H6 str. E2348/69 hydroxyglutarate oxidase YP_002330411.1 3015846 D 574521 CDS YP_002330412.1 215487981 7063522 3017137..3018585 1 NC_011601.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 3018585 gabD 7063522 gabD Escherichia coli O127:H6 str. E2348/69 succinate-semialdehyde dehydrogenase I YP_002330412.1 3017137 D 574521 CDS YP_002330413.1 215487982 7061606 3018599..3019879 1 NC_011601.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 3019879 gabT 7061606 gabT Escherichia coli O127:H6 str. E2348/69 4-aminobutyrate aminotransferase YP_002330413.1 3018599 D 574521 CDS YP_002330414.1 215487983 7061608 3020116..3021516 1 NC_011601.1 gamma-aminobutyrate transporter 3021516 gabP 7061608 gabP Escherichia coli O127:H6 str. E2348/69 gamma-aminobutyrate transporter YP_002330414.1 3020116 D 574521 CDS YP_002330415.1 215487984 7061607 3021537..3022199 1 NC_011601.1 regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 3022199 csiR 7061607 csiR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator CsiR YP_002330415.1 3021537 D 574521 CDS YP_002330416.1 215487985 7062859 complement(3022200..3022649) 1 NC_011601.1 LysM domain/BON superfamily protein 3022649 ygaU 7062859 ygaU Escherichia coli O127:H6 str. E2348/69 LysM domain/BON superfamily protein YP_002330416.1 3022200 R 574521 CDS YP_002330417.1 215487986 7064414 complement(3022733..3022891) 1 NC_011601.1 membrane protein 3022891 yqaE 7064414 yqaE Escherichia coli O127:H6 str. E2348/69 membrane protein YP_002330417.1 3022733 R 574521 CDS YP_002330418.1 215487987 7061255 3023074..3023373 1 NC_011601.1 DNA-binding transcriptional regulator 3023373 ygaV 7061255 ygaV Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330418.1 3023074 D 574521 CDS YP_002330419.1 215487988 7064415 3023383..3023907 1 NC_011601.1 inner membrane protein with hydrolase activity 3023907 ygaP 7064415 ygaP Escherichia coli O127:H6 str. E2348/69 inner membrane protein with hydrolase activity YP_002330419.1 3023383 D 574521 CDS YP_002330420.1 215487989 7064413 complement(3023954..3024358) 1 NC_011601.1 DNA binding protein 3024358 stpA 7064413 stpA Escherichia coli O127:H6 str. E2348/69 DNA binding protein YP_002330420.1 3023954 R 574521 CDS YP_002330421.1 215487990 7062776 3025025..3025474 1 NC_011601.1 hypothetical protein 3025474 ygaW 7062776 ygaW Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330421.1 3025025 D 574521 CDS YP_002330422.1 215487991 7064416 complement(3025511..3025855) 1 NC_011601.1 hypothetical protein 3025855 ygaC 7064416 ygaC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330422.1 3025511 R 574521 CDS YP_002330423.1 215487992 7064409 3026007..3026336 1 NC_011601.1 hypothetical protein 3026336 ygaM 7064409 ygaM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330423.1 3026007 D 574521 CDS YP_002330424.1 215487993 7062564 3027813..3028244 1 NC_011601.1 hypothetical protein 3028244 7062564 E2348C_2937 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330424.1 3027813 D 574521 CDS YP_002330425.1 215487994 7062565 3028453..3028698 1 NC_011601.1 glutaredoxin-like protein 3028698 nrdH 7062565 nrdH Escherichia coli O127:H6 str. E2348/69 glutaredoxin-like protein YP_002330425.1 3028453 D 574521 CDS YP_002330426.1 215487995 7065415 3028695..3029105 1 NC_011601.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 3029105 nrdI 7065415 nrdI Escherichia coli O127:H6 str. E2348/69 ribonucleotide reductase stimulatory protein YP_002330426.1 3028695 D 574521 CDS YP_002330427.1 215487996 7065416 3029078..3031222 1 NC_011601.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3031222 nrdE 7065416 nrdE Escherichia coli O127:H6 str. E2348/69 ribonucleotide-diphosphate reductase subunit alpha YP_002330427.1 3029078 D 574521 CDS YP_002330428.1 215487997 7065412 3031232..3032191 1 NC_011601.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 3032191 nrdF 7065412 nrdF Escherichia coli O127:H6 str. E2348/69 ribonucleotide-diphosphate reductase subunit beta YP_002330428.1 3031232 D 574521 CDS YP_002330429.1 215487998 7065413 3032548..3033750 1 NC_011601.1 with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 3033750 proV 7065413 proV Escherichia coli O127:H6 str. E2348/69 glycine betaine transporter ATP-binding subunit YP_002330429.1 3032548 D 574521 CDS YP_002330430.1 215487999 7061305 3033743..3034807 1 NC_011601.1 with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 3034807 proW 7061305 proW Escherichia coli O127:H6 str. E2348/69 glycine betaine transporter membrane protein YP_002330430.1 3033743 D 574521 CDS YP_002330431.1 215488000 7061306 3034865..3035857 1 NC_011601.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 3035857 proX 7061306 proX Escherichia coli O127:H6 str. E2348/69 glycine betaine transporter periplasmic subunit YP_002330431.1 3034865 D 574521 CDS YP_002330432.1 215488001 7061307 3036306..3037490 1 NC_011601.1 transporter 3037490 ygaY 7061307 ygaY Escherichia coli O127:H6 str. E2348/69 transporter YP_002330432.1 3036306 D 574521 CDS YP_002330433.1 215488002 7064417 3037614..3038351 1 NC_011601.1 transporter 3038351 ygaZ 7064417 ygaZ Escherichia coli O127:H6 str. E2348/69 transporter YP_002330433.1 3037614 D 574521 CDS YP_002330434.1 215488003 7064418 3038341..3038676 1 NC_011601.1 hypothetical protein 3038676 ygaH 7064418 ygaH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330434.1 3038341 D 574521 CDS YP_002330435.1 215488004 7064411 3038767..3039297 1 NC_011601.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 3039297 mprA 7064411 mprA Escherichia coli O127:H6 str. E2348/69 transcriptional repressor MprA YP_002330435.1 3038767 D 574521 CDS YP_002330436.1 215488005 7063827 3039424..3040596 1 NC_011601.1 multidrug efflux system 3040596 emrA 7063827 emrA Escherichia coli O127:H6 str. E2348/69 multidrug efflux system YP_002330436.1 3039424 D 574521 CDS YP_002330437.1 215488006 7063844 3040613..3042151 1 NC_011601.1 multidrug efflux system protein 3042151 emrB 7063844 emrB Escherichia coli O127:H6 str. E2348/69 multidrug efflux system protein YP_002330437.1 3040613 D 574521 CDS YP_002330438.1 215488007 7063845 3042409..3043116 1 NC_011601.1 hypothetical protein 3043116 7063845 E2348C_2951 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330438.1 3042409 D 574521 CDS YP_002330439.1 215488008 7062566 3043113..3044225 1 NC_011601.1 hypothetical protein 3044225 7062566 E2348C_2952 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330439.1 3043113 D 574521 CDS YP_002330440.1 215488009 7061107 3044413..3045786 1 NC_011601.1 transposase of ISEc13 3045786 7061107 E2348C_2953 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002330440.1 3044413 D 574521 CDS YP_002330441.1 215488010 7061108 complement(3045894..3046352) 1 NC_011601.1 transposase of IS200C 3046352 7061108 E2348C_2954 Escherichia coli O127:H6 str. E2348/69 transposase of IS200C YP_002330441.1 3045894 R 574521 CDS YP_002330442.1 215488011 7062567 complement(3046545..3047060) 1 NC_011601.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 3047060 luxS 7062567 luxS Escherichia coli O127:H6 str. E2348/69 S-ribosylhomocysteinase YP_002330442.1 3046545 R 574521 CDS YP_002330443.1 215488012 7063785 complement(3047210..3048766) 1 NC_011601.1 involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase 3048766 gshA 7063785 gshA Escherichia coli O127:H6 str. E2348/69 glutamate--cysteine ligase YP_002330443.1 3047210 R 574521 CDS YP_002330444.1 215488013 7064250 complement(3048839..3049267) 1 NC_011601.1 hypothetical protein 3049267 yqaA 7064250 yqaA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330444.1 3048839 R 574521 CDS YP_002330445.1 215488014 7061253 complement(3049264..3049830) 1 NC_011601.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase 3049830 yqaB 7061253 yqaB Escherichia coli O127:H6 str. E2348/69 fructose-1-phosphatase YP_002330445.1 3049264 R 574521 CDS YP_002330446.1 215488015 7065244 complement(3050886..3051071) 1 NC_011601.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 3051071 csrA 7065244 csrA Escherichia coli O127:H6 str. E2348/69 carbon storage regulator YP_002330446.1 3050886 R 574521 CDS YP_002330447.1 215488016 7062866 complement(3051306..3053936) 1 NC_011601.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 3053936 alaS 7062866 alaS Escherichia coli O127:H6 str. E2348/69 alanyl-tRNA synthetase YP_002330447.1 3051306 R 574521 CDS YP_002330448.1 215488017 7062429 complement(3054065..3054565) 1 NC_011601.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 3054565 recX 7062429 recX Escherichia coli O127:H6 str. E2348/69 recombination regulator RecX YP_002330448.1 3054065 R 574521 CDS YP_002330449.1 215488018 7063986 complement(3054634..3055695) 1 NC_011601.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 3055695 recA 7063986 recA Escherichia coli O127:H6 str. E2348/69 recombinase A YP_002330449.1 3054634 R 574521 CDS YP_002330450.1 215488019 7063975 complement(3055775..3056272) 1 NC_011601.1 competence damage-inducible protein A 3056272 ygaD 7063975 ygaD Escherichia coli O127:H6 str. E2348/69 competence damage-inducible protein A YP_002330450.1 3055775 R 574521 CDS YP_002330451.1 215488020 7064410 complement(3056417..3057502) 1 NC_011601.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B 3057502 mltB 7064410 mltB Escherichia coli O127:H6 str. E2348/69 murein hydrolase B YP_002330451.1 3056417 R 574521 CDS YP_002330452.1 215488021 7063795 3057756..3058721 1 NC_011601.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 3058721 gutQ 7063795 gutQ Escherichia coli O127:H6 str. E2348/69 D-arabinose 5-phosphate isomerase YP_002330452.1 3057756 D 574521 CDS YP_002330453.1 215488022 7064277 complement(3058718..3060232) 1 NC_011601.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcriptional regulator 3060232 norR 7064277 norR Escherichia coli O127:H6 str. E2348/69 anaerobic nitric oxide reductase transcriptional regulator YP_002330453.1 3058718 R 574521 CDS YP_002330454.1 215488023 7065406 3060419..3061858 1 NC_011601.1 detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 3061858 norV 7065406 norV Escherichia coli O127:H6 str. E2348/69 anaerobic nitric oxide reductase flavorubredoxin YP_002330454.1 3060419 D 574521 CDS YP_002330455.1 215488024 7065407 3061855..3062988 1 NC_011601.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 3062988 norW 7065407 norW Escherichia coli O127:H6 str. E2348/69 nitric oxide reductase YP_002330455.1 3061855 D 574521 CDS YP_002330456.1 215488025 7061109 3063173..3063694 1 NC_011601.1 transposase Orf1 of IS1397 3063694 7061109 E2348C_2969 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS1397 YP_002330456.1 3063173 D 574521 CDS YP_002330457.1 215488026 7061111 complement(3064460..3065536) 1 NC_011601.1 transposase of ISEc21 3065536 7061111 E2348C_2972 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc21 YP_002330457.1 3064460 R 574521 CDS YP_002330458.1 215488027 7062569 complement(3066375..3066686) 1 NC_011601.1 transposase Orf1 of IS3 family IS element 3066686 7062569 E2348C_2974 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS3 family IS element YP_002330458.1 3066375 R 574521 CDS YP_002330459.1 215488028 7063510 complement(3069541..3070068) 1 NC_011601.1 involved in electron transport from formate to hydrogen; electron transport protein HydN 3070068 hydN 7063510 hydN Escherichia coli O127:H6 str. E2348/69 electron transport protein HydN YP_002330459.1 3069541 R 574521 CDS YP_002330460.1 215488029 7061114 3070602..3071975 1 NC_011601.1 transposase of ISEc13 3071975 7061114 E2348C_2978 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002330460.1 3070602 D 574521 CDS YP_002330461.1 215488030 7061115 3072113..3072571 1 NC_011601.1 transposase of IS200C 3072571 7061115 E2348C_2979 Escherichia coli O127:H6 str. E2348/69 transposase of IS200C YP_002330461.1 3072113 D 574521 CDS YP_002330462.1 215488031 7062571 3072723..3073151 1 NC_011601.1 hypothetical protein 3073151 7062571 E2348C_2980 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330462.1 3072723 D 574521 CDS YP_002330463.1 215488032 7062572 complement(3073243..3073662) 1 NC_011601.1 hypothetical protein 3073662 7062572 E2348C_2981 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330463.1 3073243 R 574521 CDS YP_002330464.1 215488033 7062573 complement(3074137..3074607) 1 NC_011601.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease 3074607 hycI 7062573 hycI Escherichia coli O127:H6 str. E2348/69 hydrogenase 3 maturation protease YP_002330464.1 3074137 R 574521 CDS YP_002330465.1 215488034 7062217 complement(3074600..3075010) 1 NC_011601.1 HycH protein required for maturation of hydrogenase 3 3075010 hycH 7062217 hycH Escherichia coli O127:H6 str. E2348/69 HycH protein required for maturation of hydrogenase 3 YP_002330465.1 3074600 R 574521 CDS YP_002330466.1 215488035 7062216 complement(3075007..3075774) 1 NC_011601.1 hydrogenase 3 and formate hydrogenase complex, HycG subunit 3075774 hycG 7062216 hycG Escherichia coli O127:H6 str. E2348/69 hydrogenase 3 and formate hydrogenase complex, HycG subunit YP_002330466.1 3075007 R 574521 CDS YP_002330467.1 215488036 7062215 complement(3075774..3076316) 1 NC_011601.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit 3076316 hycF 7062215 hycF Escherichia coli O127:H6 str. E2348/69 formate hydrogenlyase complex iron-sulfur subunit YP_002330467.1 3075774 R 574521 CDS YP_002330468.1 215488037 7062214 complement(3076326..3078035) 1 NC_011601.1 hydrogenase 3, large subunit 3078035 hycE 7062214 hycE Escherichia coli O127:H6 str. E2348/69 hydrogenase 3, large subunit YP_002330468.1 3076326 R 574521 CDS YP_002330469.1 215488038 7062213 complement(3078053..3078976) 1 NC_011601.1 hydrogenase 3, membrane subunit 3078976 hycD 7062213 hycD Escherichia coli O127:H6 str. E2348/69 hydrogenase 3, membrane subunit YP_002330469.1 3078053 R 574521 CDS YP_002330470.1 215488039 7062212 complement(3078979..3080805) 1 NC_011601.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 3080805 hycC 7062212 hycC Escherichia coli O127:H6 str. E2348/69 formate hydrogenlyase subunit 3 YP_002330470.1 3078979 R 574521 CDS YP_002330471.1 215488040 7062211 complement(3080802..3081413) 1 NC_011601.1 hydrogenase 3, Fe-S subunit 3081413 hycB 7062211 hycB Escherichia coli O127:H6 str. E2348/69 hydrogenase 3, Fe-S subunit YP_002330471.1 3080802 R 574521 CDS YP_002330472.1 215488041 7062210 complement(3081538..3081999) 1 NC_011601.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA 3081999 hycA 7062210 hycA Escherichia coli O127:H6 str. E2348/69 formate hydrogenlyase regulatory protein HycA YP_002330472.1 3081538 R 574521 CDS YP_002330473.1 215488042 7062209 3082211..3082561 1 NC_011601.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 3082561 hypA 7062209 hypA Escherichia coli O127:H6 str. E2348/69 hydrogenase nickel incorporation protein YP_002330473.1 3082211 D 574521 CDS YP_002330474.1 215488043 7063504 3082565..3083437 1 NC_011601.1 GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 3083437 hypB 7063504 hypB Escherichia coli O127:H6 str. E2348/69 hydrogenase nickel incorporation protein HypB YP_002330474.1 3082565 D 574521 CDS YP_002330475.1 215488044 7063506 3083428..3083700 1 NC_011601.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 3083700 hypC 7063506 hypC Escherichia coli O127:H6 str. E2348/69 hydrogenase assembly chaperone YP_002330475.1 3083428 D 574521 CDS YP_002330476.1 215488045 7063507 3083700..3084821 1 NC_011601.1 HypD protein required for maturation of hydrogenases 3084821 hypD 7063507 hypD Escherichia coli O127:H6 str. E2348/69 HypD protein required for maturation of hydrogenases YP_002330476.1 3083700 D 574521 CDS YP_002330477.1 215488046 7063508 3084860..3085828 1 NC_011601.1 carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein HypE 3085828 hypE 7063508 hypE Escherichia coli O127:H6 str. E2348/69 carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein HypE YP_002330477.1 3084860 D 574521 CDS YP_002330478.1 215488047 7063509 3085902..3087980 1 NC_011601.1 DNA-binding transcriptional activator 3087980 fhlA 7063509 fhlA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator YP_002330478.1 3085902 D 574521 CDS YP_002330479.1 215488048 7062110 3087986..3088453 1 NC_011601.1 molybdenum-pterin-binding protein 3088453 7062110 E2348C_2997 Escherichia coli O127:H6 str. E2348/69 molybdenum-pterin-binding protein YP_002330479.1 3087986 D 574521 CDS YP_002330480.1 215488049 7062574 complement(3088492..3088836) 1 NC_011601.1 hypothetical protein 3088836 ygbA 7062574 ygbA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330480.1 3088492 R 574521 CDS YP_002330481.1 215488050 7064419 3089121..3091682 1 NC_011601.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 3091682 mutS 7064419 mutS Escherichia coli O127:H6 str. E2348/69 DNA mismatch repair protein MutS YP_002330481.1 3089121 D 574521 CDS YP_002330482.1 215488051 7060900 3091788..3092444 1 NC_011601.1 serine/threonine-specific protein phosphatase 2 3092444 pphB 7060900 pphB Escherichia coli O127:H6 str. E2348/69 serine/threonine-specific protein phosphatase 2 YP_002330482.1 3091788 D 574521 CDS YP_002330483.1 215488052 7061269 complement(3092495..3093292) 1 NC_011601.1 DNA-binding transcriptional regulator 3093292 ygbI 7061269 ygbI Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330483.1 3092495 R 574521 CDS YP_002330484.1 215488053 7064421 3093458..3094366 1 NC_011601.1 dehydrogenase, with NAD(P)-binding Rossmann-fold domain 3094366 ygbJ 7064421 ygbJ Escherichia coli O127:H6 str. E2348/69 dehydrogenase, with NAD(P)-binding Rossmann-fold domain YP_002330484.1 3093458 D 574521 CDS YP_002330485.1 215488054 7064422 3094363..3095625 1 NC_011601.1 hypothetical protein 3095625 ygbK 7064422 ygbK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330485.1 3094363 D 574521 CDS YP_002330486.1 215488055 7064423 3095622..3096260 1 NC_011601.1 aldolase 3096260 ygbL 7064423 ygbL Escherichia coli O127:H6 str. E2348/69 aldolase YP_002330486.1 3095622 D 574521 CDS YP_002330487.1 215488056 7064424 3096265..3097041 1 NC_011601.1 hypothetical protein 3097041 ygbM 7064424 ygbM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330487.1 3096265 D 574521 CDS YP_002330488.1 215488057 7064425 3097130..3098494 1 NC_011601.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; inner membrane permease YgbN 3098494 ygbN 7064425 ygbN Escherichia coli O127:H6 str. E2348/69 inner membrane permease YgbN YP_002330488.1 3097130 D 574521 CDS YP_002330489.1 215488058 7064426 complement(3098533..3098769) 1 NC_011601.1 hypothetical protein 3098769 7064426 E2348C_3007 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330489.1 3098533 R 574521 CDS YP_002330490.1 215488059 7062575 complement(3098780..3100207) 1 NC_011601.1 4-hydroxybenzoate decarboxylase 3100207 7062575 E2348C_3008 Escherichia coli O127:H6 str. E2348/69 4-hydroxybenzoate decarboxylase YP_002330490.1 3098780 R 574521 CDS YP_002330491.1 215488060 7062576 complement(3100207..3100800) 1 NC_011601.1 phenylacrylic acid decarboxylase 3100800 7062576 E2348C_3009 Escherichia coli O127:H6 str. E2348/69 phenylacrylic acid decarboxylase YP_002330491.1 3100207 R 574521 CDS YP_002330492.1 215488061 7062577 3100947..3101354 1 NC_011601.1 transcriptional regulator (MarR-family) 3101354 7062577 E2348C_3010 Escherichia coli O127:H6 str. E2348/69 transcriptional regulator (MarR-family) YP_002330492.1 3100947 D 574521 CDS YP_002330493.1 215488062 7061870 complement(3102530..3103669) 1 NC_011601.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD 3103669 nlpD 7061870 nlpD Escherichia coli O127:H6 str. E2348/69 lipoprotein NlpD YP_002330493.1 3102530 R 574521 CDS YP_002330494.1 215488063 7065403 complement(3103809..3104435) 1 NC_011601.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 3104435 pcm 7065403 pcm Escherichia coli O127:H6 str. E2348/69 protein-L-isoaspartate O-methyltransferase YP_002330494.1 3103809 R 574521 CDS YP_002330495.1 215488064 7062916 complement(3104429..3105190) 1 NC_011601.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 3105190 surE 7062916 surE Escherichia coli O127:H6 str. E2348/69 stationary phase survival protein SurE YP_002330495.1 3104429 R 574521 CDS YP_002330496.1 215488065 7061745 complement(3105171..3106220) 1 NC_011601.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 3106220 truD 7061745 truD Escherichia coli O127:H6 str. E2348/69 tRNA pseudouridine synthase D YP_002330496.1 3105171 R 574521 CDS YP_002330497.1 215488066 7062266 complement(3106217..3106696) 1 NC_011601.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 3106696 ispF 7062266 ispF Escherichia coli O127:H6 str. E2348/69 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_002330497.1 3106217 R 574521 CDS YP_002330498.1 215488067 7063555 complement(3106696..3107406) 1 NC_011601.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 3107406 ispD 7063555 ispD Escherichia coli O127:H6 str. E2348/69 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_002330498.1 3106696 R 574521 CDS YP_002330499.1 215488068 7063553 complement(3107425..3107736) 1 NC_011601.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 3107736 ftsB 7063553 ftsB Escherichia coli O127:H6 str. E2348/69 cell division protein FtsB YP_002330499.1 3107425 R 574521 CDS YP_002330500.1 215488069 7061582 complement(3107929..3108252) 1 NC_011601.1 hypothetical protein 3108252 ygbE 7061582 ygbE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330500.1 3107929 R 574521 CDS YP_002330501.1 215488070 7064420 complement(3108302..3108907) 1 NC_011601.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 3108907 cysC 7064420 cysC Escherichia coli O127:H6 str. E2348/69 adenylylsulfate kinase YP_002330501.1 3108302 R 574521 CDS YP_002330502.1 215488071 7065195 complement(3108907..3110334) 1 NC_011601.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 3110334 cysN 7065195 cysN Escherichia coli O127:H6 str. E2348/69 sulfate adenylyltransferase subunit 1 YP_002330502.1 3108907 R 574521 CDS YP_002330503.1 215488072 7065204 complement(3110336..3111244) 1 NC_011601.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 3111244 cysD 7065204 cysD Escherichia coli O127:H6 str. E2348/69 sulfate adenylyltransferase subunit 2 YP_002330503.1 3110336 R 574521 CDS YP_002330504.1 215488073 7065196 3111496..3112533 1 NC_011601.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase 3112533 iap 7065196 iap Escherichia coli O127:H6 str. E2348/69 alkaline phosphatase YP_002330504.1 3111496 D 574521 CDS YP_002330505.1 215488074 7063514 3112872..3114146 1 NC_011601.1 transposase 3114146 7063514 E2348C_3024 Escherichia coli O127:H6 str. E2348/69 transposase YP_002330505.1 3112872 D 574521 CDS YP_002330506.1 215488075 7062579 complement(3114175..3114909) 1 NC_011601.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 3114909 cysH 7062579 cysH Escherichia coli O127:H6 str. E2348/69 phosphoadenosine phosphosulfate reductase YP_002330506.1 3114175 R 574521 CDS YP_002330507.1 215488076 7065199 complement(3114983..3116695) 1 NC_011601.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 3116695 cysI 7065199 cysI Escherichia coli O127:H6 str. E2348/69 sulfite reductase subunit beta YP_002330507.1 3114983 R 574521 CDS YP_002330508.1 215488077 7065200 complement(3116695..3118494) 1 NC_011601.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha 3118494 cysJ 7065200 cysJ Escherichia coli O127:H6 str. E2348/69 sulfite reductase subunit alpha YP_002330508.1 3116695 R 574521 CDS YP_002330509.1 215488078 7065201 3118810..3119175 1 NC_011601.1 6-pyruvoyl tetrahydrobiopterin synthase 3119175 sscR 7065201 sscR Escherichia coli O127:H6 str. E2348/69 6-pyruvoyl tetrahydrobiopterin synthase YP_002330509.1 3118810 D 574521 CDS YP_002330510.1 215488079 7062761 3119253..3120524 1 NC_011601.1 oxidoreductase with FAD/NAD(P)-binding domain 3120524 ygcN 7062761 ygcN Escherichia coli O127:H6 str. E2348/69 oxidoreductase with FAD/NAD(P)-binding domain YP_002330510.1 3119253 D 574521 CDS YP_002330511.1 215488080 7064431 3120515..3120775 1 NC_011601.1 (4Fe-4S)-binding protein 3120775 ygcO 7064431 ygcO Escherichia coli O127:H6 str. E2348/69 (4Fe-4S)-binding protein YP_002330511.1 3120515 D 574521 CDS YP_002330512.1 215488081 7064432 3120792..3121367 1 NC_011601.1 anti-terminator regulatory protein 3121367 ygcP 7064432 ygcP Escherichia coli O127:H6 str. E2348/69 anti-terminator regulatory protein YP_002330512.1 3120792 D 574521 CDS YP_002330513.1 215488082 7064433 complement(3121515..3122375) 1 NC_011601.1 flavoprotein 3122375 ygcQ 7064433 ygcQ Escherichia coli O127:H6 str. E2348/69 flavoprotein YP_002330513.1 3121515 R 574521 CDS YP_002330514.1 215488083 7064434 complement(3122372..3123151) 1 NC_011601.1 flavoprotein 3123151 ygcR 7064434 ygcR Escherichia coli O127:H6 str. E2348/69 flavoprotein YP_002330514.1 3122372 R 574521 CDS YP_002330515.1 215488084 7064435 complement(3123129..3124466) 1 NC_011601.1 transporter 3124466 ygcS 7064435 ygcS Escherichia coli O127:H6 str. E2348/69 transporter YP_002330515.1 3123129 R 574521 CDS YP_002330516.1 215488085 7064436 complement(3124560..3126014) 1 NC_011601.1 FAD containing dehydrogenase 3126014 ygcU 7064436 ygcU Escherichia coli O127:H6 str. E2348/69 FAD containing dehydrogenase YP_002330516.1 3124560 R 574521 CDS YP_002330517.1 215488086 7064437 complement(3126084..3126869) 1 NC_011601.1 deoxygluconate dehydrogenase 3126869 ygcW 7064437 ygcW Escherichia coli O127:H6 str. E2348/69 deoxygluconate dehydrogenase YP_002330517.1 3126084 R 574521 CDS YP_002330518.1 215488087 7064438 3127187..3128464 1 NC_011601.1 transporter 3128464 yqcE 7064438 yqcE Escherichia coli O127:H6 str. E2348/69 transporter YP_002330518.1 3127187 D 574521 CDS YP_002330519.1 215488088 7061257 3128491..3129969 1 NC_011601.1 kinase 3129969 ygcE 7061257 ygcE Escherichia coli O127:H6 str. E2348/69 kinase YP_002330519.1 3128491 D 574521 CDS YP_002330520.1 215488089 7064428 3130134..3131054 1 NC_011601.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase 3131054 scrK 7064428 scrK Escherichia coli O127:H6 str. E2348/69 aminoimidazole riboside kinase YP_002330520.1 3130134 D 574521 CDS YP_002330521.1 215488090 7065341 3131222..3132739 1 NC_011601.1 sucrose porin 3132739 scrY 7065341 scrY Escherichia coli O127:H6 str. E2348/69 sucrose porin YP_002330521.1 3131222 D 574521 CDS YP_002330522.1 215488091 7065343 3132800..3134170 1 NC_011601.1 PTS system, sucrose-specific IIBC component 3134170 scrA 7065343 scrA Escherichia coli O127:H6 str. E2348/69 PTS system, sucrose-specific IIBC component YP_002330522.1 3132800 D 574521 CDS YP_002330523.1 215488092 7065339 3134170..3135579 1 NC_011601.1 sucrose-6-phosphate hydrolase 3135579 scrB 7065339 scrB Escherichia coli O127:H6 str. E2348/69 sucrose-6-phosphate hydrolase YP_002330523.1 3134170 D 574521 CDS YP_002330524.1 215488093 7065340 3135605..3136612 1 NC_011601.1 sucrose operon repressor 3136612 scrR 7065340 scrR Escherichia coli O127:H6 str. E2348/69 sucrose operon repressor YP_002330524.1 3135605 D 574521 CDS YP_002330525.1 215488094 7065342 complement(3136697..3137368) 1 NC_011601.1 hypothetical protein 3137368 ygcF 7065342 ygcF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330525.1 3136697 R 574521 CDS YP_002330526.1 215488095 7064429 3137662..3138534 1 NC_011601.1 hypothetical protein 3138534 ygcG 7064429 ygcG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330526.1 3137662 D 574521 CDS YP_002330527.1 215488096 7064430 complement(3138594..3139892) 1 NC_011601.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 3139892 eno 7064430 eno Escherichia coli O127:H6 str. E2348/69 phosphopyruvate hydratase YP_002330527.1 3138594 R 574521 CDS YP_002330528.1 215488097 7063851 complement(3139980..3141617) 1 NC_011601.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 3141617 pyrG 7063851 pyrG Escherichia coli O127:H6 str. E2348/69 CTP synthetase YP_002330528.1 3139980 R 574521 CDS YP_002330529.1 215488098 7063934 complement(3141845..3142636) 1 NC_011601.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era; nucleoside triphosphate pyrophosphohydrolase 3142636 mazG 7063934 mazG Escherichia coli O127:H6 str. E2348/69 nucleoside triphosphate pyrophosphohydrolase YP_002330529.1 3141845 R 574521 CDS YP_002330530.1 215488099 7065295 complement(3142708..3143043) 1 NC_011601.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA 3143043 chpA 7065295 chpA Escherichia coli O127:H6 str. E2348/69 toxin ChpA YP_002330530.1 3142708 R 574521 CDS YP_002330531.1 215488100 7062786 complement(3143043..3143291) 1 NC_011601.1 part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE 3143291 chpR 7062786 chpR Escherichia coli O127:H6 str. E2348/69 antitoxin MazE YP_002330531.1 3143043 R 574521 CDS YP_002330532.1 215488101 7062788 complement(3143369..3145603) 1 NC_011601.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase 3145603 relA 7062788 relA Escherichia coli O127:H6 str. E2348/69 GDP/GTP pyrophosphokinase YP_002330532.1 3143369 R 574521 CDS YP_002330533.1 215488102 7063987 complement(3145651..3146952) 1 NC_011601.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 3146952 rumA 7063987 rumA Escherichia coli O127:H6 str. E2348/69 23S rRNA 5-methyluridine methyltransferase YP_002330533.1 3145651 R 574521 CDS YP_002330534.1 215488103 7064578 3147009..3149765 1 NC_011601.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 3149765 barA 7064578 barA Escherichia coli O127:H6 str. E2348/69 hybrid sensory histidine kinase BarA YP_002330534.1 3147009 D 574521 CDS YP_002330535.1 215488104 7062493 complement(3149996..3151336) 1 NC_011601.1 (D)-glucarate dehydratase 1 3151336 gudD 7062493 gudD Escherichia coli O127:H6 str. E2348/69 (D)-glucarate dehydratase 1 YP_002330535.1 3149996 R 574521 CDS YP_002330536.1 215488105 7064274 complement(3151357..3152697) 1 NC_011601.1 glucarate dehydratase 3152697 gudX 7064274 gudX Escherichia coli O127:H6 str. E2348/69 glucarate dehydratase YP_002330536.1 3151357 R 574521 CDS YP_002330537.1 215488106 7064276 complement(3152699..3154051) 1 NC_011601.1 D-glucarate transporter 3154051 gudP 7064276 gudP Escherichia coli O127:H6 str. E2348/69 D-glucarate transporter YP_002330537.1 3152699 R 574521 CDS YP_002330538.1 215488107 7064275 complement(3154485..3154934) 1 NC_011601.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 3154934 yqcA 7064275 yqcA Escherichia coli O127:H6 str. E2348/69 flavodoxin YP_002330538.1 3154485 R 574521 CDS YP_002330539.1 215488108 7061256 complement(3154952..3155734) 1 NC_011601.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 3155734 truC 7061256 truC Escherichia coli O127:H6 str. E2348/69 tRNA pseudouridine synthase C YP_002330539.1 3154952 R 574521 CDS YP_002330540.1 215488109 7062265 complement(3155734..3156063) 1 NC_011601.1 hypothetical protein 3156063 ygcC 7062265 ygcC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330540.1 3155734 R 574521 CDS YP_002330541.1 215488110 7065163 complement(3156685..3157230) 1 NC_011601.1 SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd 3157230 syd 7065163 syd Escherichia coli O127:H6 str. E2348/69 SecY interacting protein Syd YP_002330541.1 3156685 R 574521 CDS YP_002330542.1 215488111 7061746 3157298..3158146 1 NC_011601.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3158146 queF 7061746 queF Escherichia coli O127:H6 str. E2348/69 7-cyano-7-deazaguanine reductase YP_002330542.1 3157298 D 574521 CDS YP_002330543.1 215488112 7063945 3158258..3159622 1 NC_011601.1 hypothetical protein 3159622 ygdH 7063945 ygdH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330543.1 3158258 D 574521 CDS YP_002330544.1 215488113 7064442 3160179..3161468 1 NC_011601.1 serine transporter 3161468 sdaC 7064442 sdaC Escherichia coli O127:H6 str. E2348/69 serine transporter YP_002330544.1 3160179 D 574521 CDS YP_002330545.1 215488114 7065346 3161526..3162893 1 NC_011601.1 L-serine deaminase II 3162893 sdaB 7065346 sdaB Escherichia coli O127:H6 str. E2348/69 L-serine deaminase II YP_002330545.1 3161526 D 574521 CDS YP_002330546.1 215488115 7065345 3162914..3163759 1 NC_011601.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3163759 xni 7065345 xni Escherichia coli O127:H6 str. E2348/69 exonuclease IX YP_002330546.1 3162914 D 574521 CDS YP_002330547.1 215488116 7064865 complement(3163814..3164965) 1 NC_011601.1 L-1,2-propanediol oxidoreductase 3164965 fucO 7064865 fucO Escherichia coli O127:H6 str. E2348/69 L-1,2-propanediol oxidoreductase YP_002330547.1 3163814 R 574521 CDS YP_002330548.1 215488117 7061596 complement(3164990..3165637) 1 NC_011601.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 3165637 fucA 7061596 fucA Escherichia coli O127:H6 str. E2348/69 L-fuculose phosphate aldolase YP_002330548.1 3164990 R 574521 CDS YP_002330549.1 215488118 7061593 3166184..3167500 1 NC_011601.1 L-fucose transporter 3167500 fucP 7061593 fucP Escherichia coli O127:H6 str. E2348/69 L-fucose transporter YP_002330549.1 3166184 D 574521 CDS YP_002330550.1 215488119 7061597 3167533..3169308 1 NC_011601.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 3169308 fucI 7061597 fucI Escherichia coli O127:H6 str. E2348/69 L-fucose isomerase YP_002330550.1 3167533 D 574521 CDS YP_002330551.1 215488120 7061594 3169387..3170835 1 NC_011601.1 L-fuculokinase 3170835 fucK 7061594 fucK Escherichia coli O127:H6 str. E2348/69 L-fuculokinase YP_002330551.1 3169387 D 574521 CDS YP_002330552.1 215488121 7061595 3170837..3171259 1 NC_011601.1 L-fucose mutarotase 3171259 fucU 7061595 fucU Escherichia coli O127:H6 str. E2348/69 L-fucose mutarotase YP_002330552.1 3170837 D 574521 CDS YP_002330553.1 215488122 7061599 3171317..3172048 1 NC_011601.1 regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 3172048 fucR 7061599 fucR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator FucR YP_002330553.1 3171317 D 574521 CDS YP_002330554.1 215488123 7061598 complement(3172092..3173192) 1 NC_011601.1 RNA 2'-O-ribose methyltransferase 3173192 ygdE 7061598 ygdE Escherichia coli O127:H6 str. E2348/69 RNA 2'-O-ribose methyltransferase YP_002330554.1 3172092 R 574521 CDS YP_002330555.1 215488124 7064441 complement(3173185..3173580) 1 NC_011601.1 hypothetical protein 3173580 ygdD 7064441 ygdD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330555.1 3173185 R 574521 CDS YP_002330556.1 215488125 7064440 complement(3173599..3174516) 1 NC_011601.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 3174516 gcvA 7064440 gcvA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator GcvA YP_002330556.1 3173599 R 574521 CDS YP_002330557.1 215488126 7061642 complement(3174867..3175094) 1 NC_011601.1 hypothetical protein 3175094 ygdI 7061642 ygdI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330557.1 3174867 R 574521 CDS YP_002330558.1 215488127 7064443 3175286..3176491 1 NC_011601.1 cysteine sulfinate desulfinase 3176491 csdA 7064443 csdA Escherichia coli O127:H6 str. E2348/69 cysteine sulfinate desulfinase YP_002330558.1 3175286 D 574521 CDS YP_002330559.1 215488128 7062849 3176491..3176934 1 NC_011601.1 Fe-S metabolism protein 3176934 ygdK 7062849 ygdK Escherichia coli O127:H6 str. E2348/69 Fe-S metabolism protein YP_002330559.1 3176491 D 574521 CDS YP_002330560.1 215488129 7064444 complement(3176985..3177791) 1 NC_011601.1 hypothetical protein 3177791 ygdL 7064444 ygdL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330560.1 3176985 R 574521 CDS YP_002330561.1 215488130 7063665 complement(3177868..3178965) 1 NC_011601.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 3178965 mltA 7063665 mltA Escherichia coli O127:H6 str. E2348/69 murein transglycosylase A YP_002330561.1 3177868 R 574521 CDS YP_002330562.1 215488131 7063772 complement(3179550..3180497) 1 NC_011601.1 dehydrogenase 3180497 7063772 E2348C_3081 Escherichia coli O127:H6 str. E2348/69 dehydrogenase YP_002330562.1 3179550 R 574521 CDS YP_002330563.1 215488132 7062580 complement(3180569..3181165) 1 NC_011601.1 phosphosugar isomerase 3181165 7062580 E2348C_3082 Escherichia coli O127:H6 str. E2348/69 phosphosugar isomerase YP_002330563.1 3180569 R 574521 CDS YP_002330564.1 215488133 7062581 complement(3181168..3182343) 1 NC_011601.1 aminotransferase 3182343 7062581 E2348C_3083 Escherichia coli O127:H6 str. E2348/69 aminotransferase YP_002330564.1 3181168 R 574521 CDS YP_002330565.1 215488134 7062583 complement(3183955..3184836) 1 NC_011601.1 antiterminator 3184836 7062583 E2348C_3085 Escherichia coli O127:H6 str. E2348/69 antiterminator YP_002330565.1 3183955 R 574521 CDS YP_002330566.1 215488135 7062584 complement(3185037..3186290) 1 NC_011601.1 N-acetylmuramoyl-L-alanine amidase 3186290 amiC 7062584 amiC Escherichia coli O127:H6 str. E2348/69 N-acetylmuramoyl-L-alanine amidase YP_002330566.1 3185037 R 574521 CDS YP_002330567.1 215488136 7062454 3186522..3187853 1 NC_011601.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3187853 argA 7062454 argA Escherichia coli O127:H6 str. E2348/69 N-acetylglutamate synthase YP_002330567.1 3186522 D 574521 CDS YP_002330568.1 215488137 7061365 complement(3187935..3189761) 1 NC_011601.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha 3189761 recD 7061365 recD Escherichia coli O127:H6 str. E2348/69 exonuclease V subunit alpha YP_002330568.1 3187935 R 574521 CDS YP_002330569.1 215488138 7063978 complement(3189761..3193303) 1 NC_011601.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta 3193303 recB 7063978 recB Escherichia coli O127:H6 str. E2348/69 exonuclease V subunit beta YP_002330569.1 3189761 R 574521 CDS YP_002330570.1 215488139 7063976 complement(3193296..3196184) 1 NC_011601.1 protease III 3196184 ptr 7063976 ptr Escherichia coli O127:H6 str. E2348/69 protease III YP_002330570.1 3193296 R 574521 CDS YP_002330571.1 215488140 7061335 complement(3196360..3199728) 1 NC_011601.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma 3199728 recC 7061335 recC Escherichia coli O127:H6 str. E2348/69 exonuclease V subunit gamma YP_002330571.1 3196360 R 574521 CDS YP_002330572.1 215488141 7063977 complement(3199741..3200064) 1 NC_011601.1 hypothetical protein 3200064 ppdC 7063977 ppdC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330572.1 3199741 R 574521 CDS YP_002330573.1 215488142 7061266 complement(3200049..3200456) 1 NC_011601.1 hypothetical protein 3200456 ygdB 7061266 ygdB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330573.1 3200049 R 574521 CDS YP_002330574.1 215488143 7064439 complement(3200453..3201016) 1 NC_011601.1 hypothetical protein 3201016 ppdB 7064439 ppdB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330574.1 3200453 R 574521 CDS YP_002330575.1 215488144 7061265 complement(3201007..3201477) 1 NC_011601.1 hypothetical protein 3201477 ppdA 7061265 ppdA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330575.1 3201007 R 574521 CDS YP_002330576.1 215488145 7061264 complement(3201662..3202456) 1 NC_011601.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 3202456 thyA 7061264 thyA Escherichia coli O127:H6 str. E2348/69 thymidylate synthase YP_002330576.1 3201662 R 574521 CDS YP_002330577.1 215488146 7061802 complement(3202463..3203338) 1 NC_011601.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 3203338 lgt 7061802 lgt Escherichia coli O127:H6 str. E2348/69 prolipoprotein diacylglyceryl transferase YP_002330577.1 3202463 R 574521 CDS YP_002330578.1 215488147 7061538 complement(3203489..3205735) 1 NC_011601.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain 3205735 ptsP 7061538 ptsP Escherichia coli O127:H6 str. E2348/69 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain YP_002330578.1 3203489 R 574521 CDS YP_002330579.1 215488148 7063910 complement(3205748..3206278) 1 NC_011601.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 3206278 nudH 7063910 nudH Escherichia coli O127:H6 str. E2348/69 dinucleoside polyphosphate hydrolase YP_002330579.1 3205748 R 574521 CDS YP_002330580.1 215488149 7065432 complement(3206631..3206777) 1 NC_011601.1 hypothetical protein 3206777 ygdT 7065432 ygdT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330580.1 3206631 R 574521 CDS YP_002330581.1 215488150 7063668 3206963..3207652 1 NC_011601.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3207652 mutH 7063668 mutH Escherichia coli O127:H6 str. E2348/69 DNA mismatch repair protein YP_002330581.1 3206963 D 574521 CDS YP_002330582.1 215488151 7060897 3207721..3208434 1 NC_011601.1 hypothetical protein 3208434 ygdQ 7060897 ygdQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330582.1 3207721 D 574521 CDS YP_002330583.1 215488152 7063666 3208572..3208790 1 NC_011601.1 hypothetical protein 3208790 ygdR 7063666 ygdR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330583.1 3208572 D 574521 CDS YP_002330584.1 215488153 7063667 3208898..3209938 1 NC_011601.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo/keto reductase 3209938 tas 7063667 tas Escherichia coli O127:H6 str. E2348/69 aldo/keto reductase YP_002330584.1 3208898 D 574521 CDS YP_002330585.1 215488154 7061754 complement(3209970..3211163) 1 NC_011601.1 lysophospholipid transporter LplT 3211163 lplT 7061754 lplT Escherichia coli O127:H6 str. E2348/69 lysophospholipid transporter LplT YP_002330585.1 3209970 R 574521 CDS YP_002330586.1 215488155 7061568 complement(3211156..3213315) 1 NC_011601.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase 3213315 aas 7061568 aas Escherichia coli O127:H6 str. E2348/69 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase YP_002330586.1 3211156 R 574521 CDS YP_002330587.1 215488156 7062882 3213901..3214932 1 NC_011601.1 controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3214932 galR 7062882 galR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator GalR YP_002330587.1 3213901 D 574521 CDS YP_002330588.1 215488157 7061621 complement(3214939..3216201) 1 NC_011601.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 3216201 lysA 7061621 lysA Escherichia coli O127:H6 str. E2348/69 diaminopimelate decarboxylase YP_002330588.1 3214939 R 574521 CDS YP_002330589.1 215488158 7065250 3216323..3217258 1 NC_011601.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; LysR family transcriptional regulator 3217258 lysR 7065250 lysR Escherichia coli O127:H6 str. E2348/69 LysR family transcriptional regulator YP_002330589.1 3216323 D 574521 CDS YP_002330590.1 215488159 7065255 complement(3217245..3217937) 1 NC_011601.1 racemase 3217937 ygeA 7065255 ygeA Escherichia coli O127:H6 str. E2348/69 racemase YP_002330590.1 3217245 R 574521 CDS YP_002330591.1 215488160 7063344 complement(3218066..3219484) 1 NC_011601.1 arabinose transporter 3219484 araE 7063344 araE Escherichia coli O127:H6 str. E2348/69 arabinose transporter YP_002330591.1 3218066 R 574521 CDS YP_002330592.1 215488161 7061116 complement(3219784..3221157) 1 NC_011601.1 transposase of ISEc13 3221157 7061116 E2348C_3112 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002330592.1 3219784 R 574521 CDS YP_002330593.1 215488162 7062585 complement(3221359..3222120) 1 NC_011601.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase 3222120 kduD 7062585 kduD Escherichia coli O127:H6 str. E2348/69 2-deoxy-D-gluconate 3-dehydrogenase YP_002330593.1 3221359 R 574521 CDS YP_002330594.1 215488163 7063582 complement(3222150..3222986) 1 NC_011601.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase 3222986 kduI 7063582 kduI Escherichia coli O127:H6 str. E2348/69 5-keto-4-deoxyuronate isomerase YP_002330594.1 3222150 R 574521 CDS YP_002330595.1 215488164 7063583 complement(3223273..3224454) 1 NC_011601.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 3224454 yqeF 7063583 yqeF Escherichia coli O127:H6 str. E2348/69 acetyl-CoA acetyltransferase YP_002330595.1 3223273 R 574521 CDS YP_002330596.1 215488165 7063185 3224709..3225938 1 NC_011601.1 transporter 3225938 yqeG 7063185 yqeG Escherichia coli O127:H6 str. E2348/69 transporter YP_002330596.1 3224709 D 574521 CDS YP_002330597.1 215488166 7061724 complement(3226406..3227161) 1 NC_011601.1 tetratricopeptide repeat transcriptional regulator 3227161 ygeR 7061724 ygeR Escherichia coli O127:H6 str. E2348/69 tetratricopeptide repeat transcriptional regulator YP_002330597.1 3226406 R 574521 CDS YP_002330598.1 215488167 7063345 3227575..3229872 1 NC_011601.1 molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3229872 xdhA 7063345 xdhA Escherichia coli O127:H6 str. E2348/69 xanthine dehydrogenase subunit XdhA YP_002330598.1 3227575 D 574521 CDS YP_002330599.1 215488168 7064859 3229883..3230761 1 NC_011601.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3230761 xdhB 7064859 xdhB Escherichia coli O127:H6 str. E2348/69 xanthine dehydrogenase subunit XdhB YP_002330599.1 3229883 D 574521 CDS YP_002330600.1 215488169 7064860 3230758..3231237 1 NC_011601.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3231237 xdhC 7064860 xdhC Escherichia coli O127:H6 str. E2348/69 xanthine dehydrogenase subunit XdhC YP_002330600.1 3230758 D 574521 CDS YP_002330601.1 215488170 7064861 complement(3231277..3233055) 1 NC_011601.1 DNA-binding transcriptional regulator 3233055 ygeV 7064861 ygeV Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330601.1 3231277 R 574521 CDS YP_002330602.1 215488171 7063346 3233534..3234721 1 NC_011601.1 aspartate/ornithine carbamoyltransferase 3234721 ygeW 7063346 ygeW Escherichia coli O127:H6 str. E2348/69 aspartate/ornithine carbamoyltransferase YP_002330602.1 3233534 D 574521 CDS YP_002330603.1 215488172 7063347 3234779..3235975 1 NC_011601.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3235975 ygeX 7063347 ygeX Escherichia coli O127:H6 str. E2348/69 diaminopropionate ammonia-lyase YP_002330603.1 3234779 D 574521 CDS YP_002330604.1 215488173 7063348 3236033..3237244 1 NC_011601.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3237244 ygeY 7063348 ygeY Escherichia coli O127:H6 str. E2348/69 peptidase YP_002330604.1 3236033 D 574521 CDS YP_002330605.1 215488174 7063349 3237297..3238682 1 NC_011601.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3238682 hyuA 7063349 hyuA Escherichia coli O127:H6 str. E2348/69 phenylhydantoinase YP_002330605.1 3237297 D 574521 CDS YP_002330606.1 215488175 7063511 3238730..3239662 1 NC_011601.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3239662 yqeA 7063511 yqeA Escherichia coli O127:H6 str. E2348/69 carbamate kinase YP_002330606.1 3238730 D 574521 CDS YP_002330607.1 215488176 7061258 complement(3239703..3241328) 1 NC_011601.1 hypothetical protein 3241328 yqeB 7061258 yqeB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330607.1 3239703 R 574521 CDS YP_002330608.1 215488177 7061259 complement(3241376..3242146) 1 NC_011601.1 hypothetical protein 3242146 yqeC 7061259 yqeC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330608.1 3241376 R 574521 CDS YP_002330609.1 215488178 7063184 3242250..3242828 1 NC_011601.1 hypothetical protein 3242828 ygfJ 7063184 ygfJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330609.1 3242250 D 574521 CDS YP_002330610.1 215488179 7061117 complement(3243846..3245219) 1 NC_011601.1 transposase of ISEc13 3245219 7061117 E2348C_3131 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002330610.1 3243846 R 574521 CDS YP_002330611.1 215488180 7062586 3247810..3249138 1 NC_011601.1 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; chlorohydrolase/aminohydrolase 3249138 ssnA 7062586 ssnA Escherichia coli O127:H6 str. E2348/69 chlorohydrolase/aminohydrolase YP_002330611.1 3247810 D 574521 CDS YP_002330612.1 215488181 7062764 3249189..3249968 1 NC_011601.1 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; selenate reductase subunit YgfM 3249968 ygfM 7062764 ygfM Escherichia coli O127:H6 str. E2348/69 selenate reductase subunit YgfM YP_002330612.1 3249189 D 574521 CDS YP_002330613.1 215488182 7064862 3253000..3254400 1 NC_011601.1 transporter 3254400 ygfO 7064862 ygfO Escherichia coli O127:H6 str. E2348/69 transporter YP_002330613.1 3253000 D 574521 CDS YP_002330614.1 215488183 7063355 3254418..3255734 1 NC_011601.1 Catalyzes the deamination of guanine; guanine deaminase 3255734 guaD 7063355 guaD Escherichia coli O127:H6 str. E2348/69 guanine deaminase YP_002330614.1 3254418 D 574521 CDS YP_002330615.1 215488184 7064273 3255770..3257137 1 NC_011601.1 transporter 3257137 ygfQ 7064273 ygfQ Escherichia coli O127:H6 str. E2348/69 transporter YP_002330615.1 3255770 D 574521 CDS YP_002330616.1 215488185 7063356 complement(3257173..3257661) 1 NC_011601.1 oxidoreductase, 4Fe-4S ferredoxin-type subunit 3257661 ygfS 7063356 ygfS Escherichia coli O127:H6 str. E2348/69 oxidoreductase, 4Fe-4S ferredoxin-type subunit YP_002330616.1 3257173 R 574521 CDS YP_002330617.1 215488186 7063357 complement(3257661..3259580) 1 NC_011601.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit 3259580 ygfT 7063357 ygfT Escherichia coli O127:H6 str. E2348/69 oxidoreductase Fe-S binding subunit YP_002330617.1 3257661 R 574521 CDS YP_002330618.1 215488187 7063358 3260016..3261464 1 NC_011601.1 transporter 3261464 ygfU 7063358 ygfU Escherichia coli O127:H6 str. E2348/69 transporter YP_002330618.1 3260016 D 574521 CDS YP_002330619.1 215488188 7063359 3261466..3261591 1 NC_011601.1 hypothetical protein 3261591 7063359 E2348C_3141 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330619.1 3261466 D 574521 CDS YP_002330620.1 215488189 7062587 3261713..3262261 1 NC_011601.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3262261 idi 7062587 idi Escherichia coli O127:H6 str. E2348/69 isopentenyl-diphosphate delta-isomerase YP_002330620.1 3261713 D 574521 CDS YP_002330621.1 215488190 7063519 complement(3262304..3263821) 1 NC_011601.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 3263821 lysS 7063519 lysS Escherichia coli O127:H6 str. E2348/69 lysyl-tRNA synthetase YP_002330621.1 3262304 R 574521 CDS YP_002330622.1 215488191 7065256 complement(join(3263831..3264853,3264855..3264929)) 1 NC_011601.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 3264929 prfB 7065256 prfB Escherichia coli O127:H6 str. E2348/69 peptide chain release factor 2 YP_002330622.1 3263831 R 574521 CDS YP_002330623.1 215488192 7061285 complement(3265020..3266753) 1 NC_011601.1 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 3266753 recJ 7061285 recJ Escherichia coli O127:H6 str. E2348/69 ssDNA exonuclease RecJ YP_002330623.1 3265020 R 574521 CDS YP_002330624.1 215488193 7063981 complement(3266759..3267469) 1 NC_011601.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 3267469 dsbC 7063981 dsbC Escherichia coli O127:H6 str. E2348/69 thiol:disulfide interchange protein DsbC YP_002330624.1 3266759 R 574521 CDS YP_002330625.1 215488194 7065064 complement(3267494..3268390) 1 NC_011601.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 3268390 xerD 7065064 xerD Escherichia coli O127:H6 str. E2348/69 site-specific tyrosine recombinase XerD YP_002330625.1 3267494 R 574521 CDS YP_002330626.1 215488195 7064864 3268502..3269023 1 NC_011601.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3269023 fldB 7064864 fldB Escherichia coli O127:H6 str. E2348/69 flavodoxin FldB YP_002330626.1 3268502 D 574521 CDS YP_002330627.1 215488196 7062137 complement(3269063..3269470) 1 NC_011601.1 hypothetical protein 3269470 ygfX 7062137 ygfX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330627.1 3269063 R 574521 CDS YP_002330628.1 215488197 7063360 complement(3269451..3269717) 1 NC_011601.1 hypothetical protein 3269717 ygfY 7063360 ygfY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330628.1 3269451 R 574521 CDS YP_002330629.1 215488198 7063361 3269960..3270940 1 NC_011601.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator 3270940 ygfZ 7063361 ygfZ Escherichia coli O127:H6 str. E2348/69 global regulator YP_002330629.1 3269960 D 574521 CDS YP_002330630.1 215488199 7063362 complement(3271017..3271676) 1 NC_011601.1 oxidoreductase, inner membrane subunit 3271676 yqfA 7063362 yqfA Escherichia coli O127:H6 str. E2348/69 oxidoreductase, inner membrane subunit YP_002330630.1 3271017 R 574521 CDS YP_002330631.1 215488200 7063187 complement(3271840..3272151) 1 NC_011601.1 hypothetical protein 3272151 yqfB 7063187 yqfB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330631.1 3271840 R 574521 CDS YP_002330632.1 215488201 7063188 3272190..3273629 1 NC_011601.1 6-phospho-beta-glucosidase 3273629 bglA 7063188 bglA Escherichia coli O127:H6 str. E2348/69 6-phospho-beta-glucosidase YP_002330632.1 3272190 D 574521 CDS YP_002330633.1 215488202 7062512 complement(3273795..3276668) 1 NC_011601.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 3276668 gcvP 7062512 gcvP Escherichia coli O127:H6 str. E2348/69 glycine dehydrogenase YP_002330633.1 3273795 R 574521 CDS YP_002330634.1 215488203 7061644 complement(3276787..3277176) 1 NC_011601.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3277176 gcvH 7061644 gcvH Escherichia coli O127:H6 str. E2348/69 glycine cleavage system protein H YP_002330634.1 3276787 R 574521 CDS YP_002330635.1 215488204 7061643 complement(3277200..3278294) 1 NC_011601.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 3278294 gcvT 7061643 gcvT Escherichia coli O127:H6 str. E2348/69 glycine cleavage system aminomethyltransferase T YP_002330635.1 3277200 R 574521 CDS YP_002330636.1 215488205 7061646 complement(3278742..3279944) 1 NC_011601.1 hypothetical protein 3279944 visC 7061646 visC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330636.1 3278742 R 574521 CDS YP_002330637.1 215488206 7062361 complement(3279967..3281145) 1 NC_011601.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase 3281145 ubiH 7062361 ubiH Escherichia coli O127:H6 str. E2348/69 2-octaprenyl-6-methoxyphenyl hydroxylase YP_002330637.1 3279967 R 574521 CDS YP_002330638.1 215488207 7062297 complement(3281142..3282467) 1 NC_011601.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 3282467 pepP 7062297 pepP Escherichia coli O127:H6 str. E2348/69 proline aminopeptidase P II YP_002330638.1 3281142 R 574521 CDS YP_002330639.1 215488208 7060703 complement(3282493..3283071) 1 NC_011601.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 3283071 ygfB 7060703 ygfB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330639.1 3282493 R 574521 CDS YP_002330640.1 215488209 7063351 3283239..3283568 1 NC_011601.1 Z-ring-associated protein 3283568 zapA 7063351 zapA Escherichia coli O127:H6 str. E2348/69 Z-ring-associated protein YP_002330640.1 3283239 D 574521 CDS YP_002330641.1 215488210 7062768 3283814..3284416 1 NC_011601.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase 3284416 ygfA 7062768 ygfA Escherichia coli O127:H6 str. E2348/69 ligase YP_002330641.1 3283814 D 574521 CDS YP_002330642.1 215488211 7064602 complement(3284805..3286037) 1 NC_011601.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 3286037 serA 7064602 serA Escherichia coli O127:H6 str. E2348/69 D-3-phosphoglycerate dehydrogenase YP_002330642.1 3284805 R 574521 CDS YP_002330643.1 215488212 7065366 complement(3286293..3286952) 1 NC_011601.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 3286952 rpiA 7065366 rpiA Escherichia coli O127:H6 str. E2348/69 ribose-5-phosphate isomerase A YP_002330643.1 3286293 R 574521 CDS YP_002330644.1 215488213 7061827 3287651..3288544 1 NC_011601.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3288544 argP 7061827 argP Escherichia coli O127:H6 str. E2348/69 chromosome replication initiation inhibitor protein YP_002330644.1 3287651 D 574521 CDS YP_002330645.1 215488214 7065338 complement(3289685..3290656) 1 NC_011601.1 DNA-binding transcriptional regulator 3290656 ygfI 7065338 ygfI Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330645.1 3289685 R 574521 CDS YP_002330646.1 215488215 7063352 complement(3290814..3291554) 1 NC_011601.1 hypothetical protein 3291554 yggE 7063352 yggE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330646.1 3290814 R 574521 CDS YP_002330647.1 215488216 7063365 complement(3291647..3292282) 1 NC_011601.1 Involved in the export of arginine; arginine exporter protein 3292282 argO 7063365 argO Escherichia coli O127:H6 str. E2348/69 arginine exporter protein YP_002330647.1 3291647 R 574521 CDS YP_002330648.1 215488217 7061373 complement(3292421..3293281) 1 NC_011601.1 participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS 3293281 mscS 7061373 mscS Escherichia coli O127:H6 str. E2348/69 mechanosensitive channel MscS YP_002330648.1 3292421 R 574521 CDS YP_002330649.1 215488218 7060873 complement(3293472..3294551) 1 NC_011601.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 3294551 fbaA 7060873 fbaA Escherichia coli O127:H6 str. E2348/69 fructose-bisphosphate aldolase YP_002330649.1 3293472 R 574521 CDS YP_002330650.1 215488219 7062081 complement(3294765..3295928) 1 NC_011601.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 3295928 pgk 7062081 pgk Escherichia coli O127:H6 str. E2348/69 phosphoglycerate kinase YP_002330650.1 3294765 R 574521 CDS YP_002330651.1 215488220 7060714 complement(3295978..3296997) 1 NC_011601.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 3296997 epd 7060714 epd Escherichia coli O127:H6 str. E2348/69 erythrose 4-phosphate dehydrogenase YP_002330651.1 3295978 R 574521 CDS YP_002330652.1 215488221 7063862 3297369..3297800 1 NC_011601.1 DNA-binding protein 3297800 7063862 E2348C_3175 Escherichia coli O127:H6 str. E2348/69 DNA-binding protein YP_002330652.1 3297369 D 574521 CDS YP_002330653.1 215488222 7062588 3297823..3298401 1 NC_011601.1 transporter 3298401 7062588 E2348C_3176 Escherichia coli O127:H6 str. E2348/69 transporter YP_002330653.1 3297823 D 574521 CDS YP_002330654.1 215488223 7062589 3298402..3299109 1 NC_011601.1 lipoprotein 3299109 7062589 E2348C_3177 Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002330654.1 3298402 D 574521 CDS YP_002330655.1 215488224 7062590 3299097..3299774 1 NC_011601.1 ABC transporter ATP-binding protein 3299774 7062590 E2348C_3178 Escherichia coli O127:H6 str. E2348/69 ABC transporter ATP-binding protein YP_002330655.1 3299097 D 574521 CDS YP_002330656.1 215488225 7062592 complement(3300417..3301130) 1 NC_011601.1 fructose transport system kinase 3301130 frcK 7062592 frcK Escherichia coli O127:H6 str. E2348/69 fructose transport system kinase YP_002330656.1 3300417 R 574521 CDS YP_002330657.1 215488226 7063363 complement(3301127..3301636) 1 NC_011601.1 DNA-binding transcriptional regulator 3301636 yggD 7063363 yggD Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330657.1 3301127 R 574521 CDS YP_002330658.1 215488227 7063364 complement(3301658..3302623) 1 NC_011601.1 fructose-1,6-bisphosphatase II-like protein 3302623 yggF 7063364 yggF Escherichia coli O127:H6 str. E2348/69 fructose-1,6-bisphosphatase II-like protein YP_002330658.1 3301658 R 574521 CDS YP_002330659.1 215488228 7063366 complement(3302620..3303897) 1 NC_011601.1 dehydrogenase 3303897 yggP 7063366 yggP Escherichia coli O127:H6 str. E2348/69 dehydrogenase YP_002330659.1 3302620 R 574521 CDS YP_002330660.1 215488229 7063372 complement(3303912..3305300) 1 NC_011601.1 fused mannitol-specific PTS enzymes: IIB component/IIC component 3305300 cmtA 7063372 cmtA Escherichia coli O127:H6 str. E2348/69 fused mannitol-specific PTS enzymes: IIB component/IIC component YP_002330660.1 3303912 R 574521 CDS YP_002330661.1 215488230 7062818 complement(3305328..3305771) 1 NC_011601.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; mannitol phosphotransferase subunit EIIA 3305771 cmtB 7062818 cmtB Escherichia coli O127:H6 str. E2348/69 mannitol phosphotransferase subunit EIIA YP_002330661.1 3305328 R 574521 CDS YP_002330662.1 215488231 7062819 3306148..3307056 1 NC_011601.1 HflC-like, SPFC domain-containing protein 3307056 7062819 E2348C_3186 Escherichia coli O127:H6 str. E2348/69 HflC-like, SPFC domain-containing protein YP_002330662.1 3306148 D 574521 CDS YP_002330663.1 215488232 7062593 complement(3307276..3309267) 1 NC_011601.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3309267 tktA 7062593 tktA Escherichia coli O127:H6 str. E2348/69 transketolase YP_002330663.1 3307276 R 574521 CDS YP_002330664.1 215488233 7061806 3309545..3310303 1 NC_011601.1 peptidase 3310303 yggG 7061806 yggG Escherichia coli O127:H6 str. E2348/69 peptidase YP_002330664.1 3309545 D 574521 CDS YP_002330665.1 215488234 7063367 complement(3310507..3311427) 1 NC_011601.1 catalyzes the formation of putrescine from agmatine; agmatinase 3311427 speB 7063367 speB Escherichia coli O127:H6 str. E2348/69 agmatinase YP_002330665.1 3310507 R 574521 CDS YP_002330666.1 215488235 7062741 complement(3311563..3312294) 1 NC_011601.1 hypothetical protein 3312294 7062741 E2348C_3190 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330666.1 3311563 R 574521 CDS YP_002330667.1 215488236 7062594 complement(3312440..3314416) 1 NC_011601.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 3314416 speA 7062594 speA Escherichia coli O127:H6 str. E2348/69 arginine decarboxylase YP_002330667.1 3312440 R 574521 CDS YP_002330668.1 215488237 7062740 complement(3314425..3314556) 1 NC_011601.1 hypothetical protein 3314556 yqgB 7062740 yqgB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330668.1 3314425 R 574521 CDS YP_002330669.1 215488238 7063190 3314692..3314907 1 NC_011601.1 hypothetical protein 3314907 yqgC 7063190 yqgC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330669.1 3314692 D 574521 CDS YP_002330670.1 215488239 7063191 complement(3314904..3315155) 1 NC_011601.1 hypothetical protein 3315155 yqgD 7063191 yqgD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330670.1 3314904 R 574521 CDS YP_002330671.1 215488240 7063192 3315211..3316365 1 NC_011601.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3316365 metK 7063192 metK Escherichia coli O127:H6 str. E2348/69 S-adenosylmethionine synthetase YP_002330671.1 3315211 D 574521 CDS YP_002330672.1 215488241 7063765 3316801..3318195 1 NC_011601.1 D-galactose transporter 3318195 galP 7063765 galP Escherichia coli O127:H6 str. E2348/69 D-galactose transporter YP_002330672.1 3316801 D 574521 CDS YP_002330673.1 215488242 7061620 3318272..3318769 1 NC_011601.1 hypothetical protein 3318769 yggI 7061620 yggI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330673.1 3318272 D 574521 CDS YP_002330674.1 215488243 7063368 3318864..3319571 1 NC_011601.1 DNA-specific endonuclease I 3319571 endA 7063368 endA Escherichia coli O127:H6 str. E2348/69 DNA-specific endonuclease I YP_002330674.1 3318864 D 574521 CDS YP_002330675.1 215488244 7063850 3319650..3320381 1 NC_011601.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3320381 rsmE 7063850 rsmE Escherichia coli O127:H6 str. E2348/69 16S ribosomal RNA methyltransferase RsmE YP_002330675.1 3319650 D 574521 CDS YP_002330676.1 215488245 7064558 3320394..3321344 1 NC_011601.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3321344 gshB 7064558 gshB Escherichia coli O127:H6 str. E2348/69 glutathione synthetase YP_002330676.1 3320394 D 574521 CDS YP_002330677.1 215488246 7064251 3321453..3322016 1 NC_011601.1 hypothetical protein 3322016 yqgE 7064251 yqgE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330677.1 3321453 D 574521 CDS YP_002330678.1 215488247 7063193 3322016..3322432 1 NC_011601.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3322432 yqgF 7063193 yqgF Escherichia coli O127:H6 str. E2348/69 Holliday junction resolvase-like protein YP_002330678.1 3322016 D 574521 CDS YP_002330679.1 215488248 7063194 complement(3322439..3323419) 1 NC_011601.1 transporter 3323419 yggR 7063194 yggR Escherichia coli O127:H6 str. E2348/69 transporter YP_002330679.1 3322439 R 574521 CDS YP_002330680.1 215488249 7063373 3323437..3324141 1 NC_011601.1 hypothetical protein 3324141 yggS 7063373 yggS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330680.1 3323437 D 574521 CDS YP_002330681.1 215488250 7063374 3324159..3324725 1 NC_011601.1 hypothetical protein 3324725 yggT 7063374 yggT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330681.1 3324159 D 574521 CDS YP_002330682.1 215488251 7063375 3324722..3325012 1 NC_011601.1 hypothetical protein 3325012 yggU 7063375 yggU Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330682.1 3324722 D 574521 CDS YP_002330683.1 215488252 7063376 3325020..3325613 1 NC_011601.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 3325613 rdgB 7063376 rdgB Escherichia coli O127:H6 str. E2348/69 deoxyribonucleotide triphosphate pyrophosphatase YP_002330683.1 3325020 D 574521 CDS YP_002330684.1 215488253 7063968 3325606..3326742 1 NC_011601.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3326742 rdgW 7063968 rdgW Escherichia coli O127:H6 str. E2348/69 coproporphyrinogen III oxidase YP_002330684.1 3325606 D 574521 CDS YP_002330685.1 215488254 7063970 complement(3326807..3327814) 1 NC_011601.1 hypothetical protein 3327814 yggM 7063970 yggM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330685.1 3326807 R 574521 CDS YP_002330686.1 215488255 7063370 complement(3327931..3328977) 1 NC_011601.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 3328977 ansB 7063370 ansB Escherichia coli O127:H6 str. E2348/69 L-asparaginase II YP_002330686.1 3327931 R 574521 CDS YP_002330687.1 215488256 7061345 complement(3329153..3329872) 1 NC_011601.1 hypothetical protein 3329872 yggN 7061345 yggN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330687.1 3329153 R 574521 CDS YP_002330688.1 215488257 7063371 complement(3330056..3330382) 1 NC_011601.1 hypothetical protein 3330382 yggL 7063371 yggL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330688.1 3330056 R 574521 CDS YP_002330689.1 215488258 7063369 complement(3330382..3331101) 1 NC_011601.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 3331101 trmB 7063369 trmB Escherichia coli O127:H6 str. E2348/69 tRNA (guanine-N(7)-)-methyltransferase YP_002330689.1 3330382 R 574521 CDS YP_002330690.1 215488259 7062244 3331262..3332314 1 NC_011601.1 adenine DNA glycosylase 3332314 mutY 7062244 mutY Escherichia coli O127:H6 str. E2348/69 adenine DNA glycosylase YP_002330690.1 3331262 D 574521 CDS YP_002330691.1 215488260 7060902 3332342..3332617 1 NC_011601.1 hypothetical protein 3332617 yggX 7060902 yggX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330691.1 3332342 D 574521 CDS YP_002330692.1 215488261 7063377 3332682..3333761 1 NC_011601.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3333761 mltC 7063377 mltC Escherichia coli O127:H6 str. E2348/69 murein transglycosylase C YP_002330692.1 3332682 D 574521 CDS YP_002330693.1 215488262 7063796 3333963..3335219 1 NC_011601.1 nucleoside transporter 3335219 nupG 7063796 nupG Escherichia coli O127:H6 str. E2348/69 nucleoside transporter YP_002330693.1 3333963 D 574521 CDS YP_002330694.1 215488263 7062787 complement(3335268..3337403) 1 NC_011601.1 ornithine decarboxylase 3337403 speC 7062787 speC Escherichia coli O127:H6 str. E2348/69 ornithine decarboxylase YP_002330694.1 3335268 R 574521 CDS YP_002330695.1 215488264 7062742 3337802..3338509 1 NC_011601.1 hypothetical protein 3338509 yqgA 7062742 yqgA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330695.1 3337802 D 574521 CDS YP_002330696.1 215488265 7064959 3338888..3340153 1 NC_011601.1 integrase 3340153 7064959 E2348C_3220 Escherichia coli O127:H6 str. E2348/69 integrase YP_002330696.1 3338888 D 574521 CDS YP_002330697.1 215488266 7061119 3341144..3341818 1 NC_011601.1 transposase Orf1 of IS683 3341818 7061119 E2348C_3222 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS683 YP_002330697.1 3341144 D 574521 CDS YP_002330698.1 215488267 7062595 3341815..3342162 1 NC_011601.1 transposase Orf2 of IS683 3342162 7062595 E2348C_3223 Escherichia coli O127:H6 str. E2348/69 transposase Orf2 of IS683 YP_002330698.1 3341815 D 574521 CDS YP_002330699.1 215488268 7062598 complement(3344484..3345032) 1 NC_011601.1 PagC-like membrane protein 3345032 7062598 E2348C_3226 Escherichia coli O127:H6 str. E2348/69 PagC-like membrane protein YP_002330699.1 3344484 R 574521 CDS YP_002330700.1 215488269 7062599 complement(3345140..3345334) 1 NC_011601.1 hypothetical protein 3345334 7062599 E2348C_3227 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330700.1 3345140 R 574521 CDS YP_002330701.1 215488270 7062600 3347579..3347812 1 NC_011601.1 hypothetical protein 3347812 7062600 E2348C_3229 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330701.1 3347579 D 574521 CDS YP_002330702.1 215488271 7062601 3348020..3349669 1 NC_011601.1 T3SS secreted effector EspL-like protein 3349669 7062601 E2348C_3230 Escherichia coli O127:H6 str. E2348/69 T3SS secreted effector EspL-like protein YP_002330702.1 3348020 D 574521 CDS YP_002330703.1 215488272 7061121 3350278..3351267 1 NC_011601.1 T3SS secreted effector NleB-like protein 3351267 7061121 E2348C_3231 Escherichia coli O127:H6 str. E2348/69 T3SS secreted effector NleB-like protein YP_002330703.1 3350278 D 574521 CDS YP_002330704.1 215488273 7062602 3351316..3351990 1 NC_011601.1 T3SS secreted effector NleE-like protein 3351990 7062602 E2348C_3232 Escherichia coli O127:H6 str. E2348/69 T3SS secreted effector NleE-like protein YP_002330704.1 3351316 D 574521 CDS YP_002330705.1 215488274 7062603 3353864..3363535 1 NC_011601.1 Efa1/LifA protein 3363535 7062603 E2348C_3234 Escherichia coli O127:H6 str. E2348/69 Efa1/LifA protein YP_002330705.1 3353864 D 574521 CDS YP_002330706.1 215488275 7061124 3364189..3364614 1 NC_011601.1 transposase Orf1 of IS682 3364614 7061124 E2348C_3236 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS682 YP_002330706.1 3364189 D 574521 CDS YP_002330707.1 215488276 7062604 3364611..3364961 1 NC_011601.1 transposase Orf2 of IS682 3364961 7062604 E2348C_3237 Escherichia coli O127:H6 str. E2348/69 transposase Orf2 of IS682 YP_002330707.1 3364611 D 574521 CDS YP_002330708.1 215488277 7062605 3365174..3366577 1 NC_011601.1 transposase Orf3 of IS682 3366577 7062605 E2348C_3238 Escherichia coli O127:H6 str. E2348/69 transposase Orf3 of IS682 YP_002330708.1 3365174 D 574521 CDS YP_002330709.1 215488278 7062606 3366913..3367959 1 NC_011601.1 transposase 3367959 7062606 E2348C_3239 Escherichia coli O127:H6 str. E2348/69 transposase YP_002330709.1 3366913 D 574521 CDS YP_002330710.1 215488279 7062607 complement(3368164..3368715) 1 NC_011601.1 general secretion pathway protein YghD 3368715 gspM 7062607 gspM Escherichia coli O127:H6 str. E2348/69 general secretion pathway protein YghD YP_002330710.1 3368164 R 574521 CDS YP_002330711.1 215488280 7064268 complement(3368717..3369886) 1 NC_011601.1 similar to general secretory pathway protein L; GspL-like protein 3369886 gspL 7064268 gspL Escherichia coli O127:H6 str. E2348/69 GspL-like protein YP_002330711.1 3368717 R 574521 CDS YP_002330712.1 215488281 7064267 complement(3369892..3370869) 1 NC_011601.1 type II secretion protein 3370869 gspK 7064267 gspK Escherichia coli O127:H6 str. E2348/69 type II secretion protein YP_002330712.1 3369892 R 574521 CDS YP_002330713.1 215488282 7064266 complement(3370866..3371471) 1 NC_011601.1 type II secretion protein 3371471 gspJ 7064266 gspJ Escherichia coli O127:H6 str. E2348/69 type II secretion protein YP_002330713.1 3370866 R 574521 CDS YP_002330714.1 215488283 7064265 complement(3371468..3371839) 1 NC_011601.1 type II secretion protein 3371839 gspI 7064265 gspI Escherichia coli O127:H6 str. E2348/69 type II secretion protein YP_002330714.1 3371468 R 574521 CDS YP_002330715.1 215488284 7064264 complement(3371836..3372399) 1 NC_011601.1 type II secretion protein 3372399 gspH 7064264 gspH Escherichia coli O127:H6 str. E2348/69 type II secretion protein YP_002330715.1 3371836 R 574521 CDS YP_002330716.1 215488285 7064263 complement(3372403..3372858) 1 NC_011601.1 type II secretion protein 3372858 gspG 7064263 gspG Escherichia coli O127:H6 str. E2348/69 type II secretion protein YP_002330716.1 3372403 R 574521 CDS YP_002330717.1 215488286 7064262 complement(3372875..3374098) 1 NC_011601.1 type II secretion protein 3374098 gspF 7064262 gspF Escherichia coli O127:H6 str. E2348/69 type II secretion protein YP_002330717.1 3372875 R 574521 CDS YP_002330718.1 215488287 7064261 complement(3374098..3375591) 1 NC_011601.1 type II secretion protein 3375591 gspE 7064261 gspE Escherichia coli O127:H6 str. E2348/69 type II secretion protein YP_002330718.1 3374098 R 574521 CDS YP_002330719.1 215488288 7064260 complement(3375591..3377651) 1 NC_011601.1 type II secretion protein 3377651 gspD 7064260 gspD Escherichia coli O127:H6 str. E2348/69 type II secretion protein YP_002330719.1 3375591 R 574521 CDS YP_002330720.1 215488289 7064259 complement(3377681..3378640) 1 NC_011601.1 part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm; type II secretion protein GspC 3378640 gspC 7064259 gspC Escherichia coli O127:H6 str. E2348/69 type II secretion protein GspC YP_002330720.1 3377681 R 574521 CDS YP_002330721.1 215488290 7064258 complement(3378658..3379068) 1 NC_011601.1 hypothetical protein 3379068 yghG 7064258 yghG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330721.1 3378658 R 574521 CDS YP_002330722.1 215488291 7063380 complement(3379134..3379943) 1 NC_011601.1 bifunctional prepilin leader peptidase/methylase 3379943 pppA 7063380 pppA Escherichia coli O127:H6 str. E2348/69 bifunctional prepilin leader peptidase/methylase YP_002330722.1 3379134 R 574521 CDS YP_002330723.1 215488292 7061275 complement(3380138..3384712) 1 NC_011601.1 inner membrane lipoprotein 3384712 yghJ 7061275 yghJ Escherichia coli O127:H6 str. E2348/69 inner membrane lipoprotein YP_002330723.1 3380138 R 574521 CDS YP_002330724.1 215488293 7063381 complement(3385198..3386880) 1 NC_011601.1 glycolate transporter 3386880 glcA 7063381 glcA Escherichia coli O127:H6 str. E2348/69 glycolate transporter YP_002330724.1 3385198 R 574521 CDS YP_002330725.1 215488294 7061152 complement(3387235..3389406) 1 NC_011601.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 3389406 glcB 7061152 glcB Escherichia coli O127:H6 str. E2348/69 malate synthase G YP_002330725.1 3387235 R 574521 CDS YP_002330726.1 215488295 7061659 complement(3389428..3389832) 1 NC_011601.1 hypothetical protein 3389832 glcG 7061659 glcG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330726.1 3389428 R 574521 CDS YP_002330727.1 215488296 7061664 complement(3389837..3391060) 1 NC_011601.1 glycolate oxidase iron-sulfur subunit 3391060 glcF 7061664 glcF Escherichia coli O127:H6 str. E2348/69 glycolate oxidase iron-sulfur subunit YP_002330727.1 3389837 R 574521 CDS YP_002330728.1 215488297 7061663 complement(3391071..3392123) 1 NC_011601.1 glycolate oxidase FAD binding subunit 3392123 glcE 7061663 glcE Escherichia coli O127:H6 str. E2348/69 glycolate oxidase FAD binding subunit YP_002330728.1 3391071 R 574521 CDS YP_002330729.1 215488298 7061662 complement(3392123..3393622) 1 NC_011601.1 glycolate oxidase subunit GlcD 3393622 glcD 7061662 glcD Escherichia coli O127:H6 str. E2348/69 glycolate oxidase subunit GlcD YP_002330729.1 3392123 R 574521 CDS YP_002330730.1 215488299 7061661 3393873..3394637 1 NC_011601.1 DNA-binding transcriptional regulator GlcC 3394637 glcC 7061661 glcC Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator GlcC YP_002330730.1 3393873 D 574521 CDS YP_002330731.1 215488300 7061660 complement(3394644..3395786) 1 NC_011601.1 DNA-binding transcriptional regulator 3395786 yghO 7061660 yghO Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330731.1 3394644 R 574521 CDS YP_002330732.1 215488301 7063382 3396139..3397872 1 NC_011601.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3397872 7063382 E2348C_3262 Escherichia coli O127:H6 str. E2348/69 acyl-CoA synthetase YP_002330732.1 3396139 D 574521 CDS YP_002330733.1 215488302 7062608 3397869..3398783 1 NC_011601.1 hypothetical protein 3398783 7062608 E2348C_3263 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330733.1 3397869 D 574521 CDS YP_002330734.1 215488303 7062609 3398815..3399063 1 NC_011601.1 acyl carrier protein 3399063 7062609 E2348C_3264 Escherichia coli O127:H6 str. E2348/69 acyl carrier protein YP_002330734.1 3398815 D 574521 CDS YP_002330735.1 215488304 7062610 3399063..3400235 1 NC_011601.1 aminotransferase 3400235 7062610 E2348C_3265 Escherichia coli O127:H6 str. E2348/69 aminotransferase YP_002330735.1 3399063 D 574521 CDS YP_002330736.1 215488305 7062611 complement(3400270..3401349) 1 NC_011601.1 permease 3401349 7062611 E2348C_3266 Escherichia coli O127:H6 str. E2348/69 permease YP_002330736.1 3400270 R 574521 CDS YP_002330737.1 215488306 7062612 complement(3401346..3402416) 1 NC_011601.1 permease 3402416 7062612 E2348C_3267 Escherichia coli O127:H6 str. E2348/69 permease YP_002330737.1 3401346 R 574521 CDS YP_002330738.1 215488307 7062613 complement(3402446..3403006) 1 NC_011601.1 transcriptional regulator 3403006 7062613 E2348C_3268 Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002330738.1 3402446 R 574521 CDS YP_002330739.1 215488308 7062614 complement(3403018..3403842) 1 NC_011601.1 hypothetical protein 3403842 7062614 E2348C_3269 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330739.1 3403018 R 574521 CDS YP_002330740.1 215488309 7062615 complement(3403842..3405191) 1 NC_011601.1 hypothetical protein 3405191 yghQ 7062615 yghQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330740.1 3403842 R 574521 CDS YP_002330741.1 215488310 7063383 complement(3405237..3405995) 1 NC_011601.1 hypothetical protein 3405995 yghR 7063383 yghR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330741.1 3405237 R 574521 CDS YP_002330742.1 215488311 7063384 complement(3406027..3406740) 1 NC_011601.1 hypothetical protein 3406740 yghS 7063384 yghS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330742.1 3406027 R 574521 CDS YP_002330743.1 215488312 7063385 3406915..3407607 1 NC_011601.1 hypothetical protein 3407607 yghT 7063385 yghT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330743.1 3406915 D 574521 CDS YP_002330744.1 215488313 7063386 complement(3407656..3409155) 1 NC_011601.1 phosphate transporter 3409155 pitB 7063386 pitB Escherichia coli O127:H6 str. E2348/69 phosphate transporter YP_002330744.1 3407656 R 574521 CDS YP_002330745.1 215488314 7060753 complement(3409446..3411305) 1 NC_011601.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 3411305 gsp 7060753 gsp Escherichia coli O127:H6 str. E2348/69 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase YP_002330745.1 3409446 R 574521 CDS YP_002330746.1 215488315 7064257 3411510..3412376 1 NC_011601.1 YghU; B2989; one of eight glutathione transferases from E. coli; glutathione S-transferase 3412376 yghU 7064257 yghU Escherichia coli O127:H6 str. E2348/69 glutathione S-transferase YP_002330746.1 3411510 D 574521 CDS YP_002330747.1 215488316 7063387 complement(3412518..3412766) 1 NC_011601.1 hydrogenase 2 accessory protein HypG 3412766 hybG 7063387 hybG Escherichia coli O127:H6 str. E2348/69 hydrogenase 2 accessory protein HypG YP_002330747.1 3412518 R 574521 CDS YP_002330748.1 215488317 7062207 complement(3412779..3413120) 1 NC_011601.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 3413120 hybF 7062207 hybF Escherichia coli O127:H6 str. E2348/69 hydrogenase nickel incorporation protein HybF YP_002330748.1 3412779 R 574521 CDS YP_002330749.1 215488318 7062206 complement(3413113..3413601) 1 NC_011601.1 hydrogenase 2-specific chaperone 3413601 hybE 7062206 hybE Escherichia coli O127:H6 str. E2348/69 hydrogenase 2-specific chaperone YP_002330749.1 3413113 R 574521 CDS YP_002330750.1 215488319 7062205 complement(3413594..3414088) 1 NC_011601.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 3414088 hybD 7062205 hybD Escherichia coli O127:H6 str. E2348/69 hydrogenase 2 maturation endopeptidase YP_002330750.1 3413594 R 574521 CDS YP_002330751.1 215488320 7062204 complement(3414088..3415791) 1 NC_011601.1 involved in hydrogen uptake; hydrogenase 2 large subunit 3415791 hybC 7062204 hybC Escherichia coli O127:H6 str. E2348/69 hydrogenase 2 large subunit YP_002330751.1 3414088 R 574521 CDS YP_002330752.1 215488321 7062203 complement(3415788..3416966) 1 NC_011601.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit 3416966 hybB 7062203 hybB Escherichia coli O127:H6 str. E2348/69 hydrogenase 2 b cytochrome subunit YP_002330752.1 3415788 R 574521 CDS YP_002330753.1 215488322 7062202 complement(3416956..3417942) 1 NC_011601.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 3417942 hybA 7062202 hybA Escherichia coli O127:H6 str. E2348/69 hydrogenase 2 protein HybA YP_002330753.1 3416956 R 574521 CDS YP_002330754.1 215488323 7062201 complement(3417945..3419063) 1 NC_011601.1 involved in hydrogen uptake; hydrogenase 2 small subunit 3419063 hybO 7062201 hybO Escherichia coli O127:H6 str. E2348/69 hydrogenase 2 small subunit YP_002330754.1 3417945 R 574521 CDS YP_002330755.1 215488324 7062208 complement(3419252..3419539) 1 NC_011601.1 hypothetical protein 3419539 yghW 7062208 yghW Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330755.1 3419252 R 574521 CDS YP_002330756.1 215488325 7063388 complement(3419658..3420545) 1 NC_011601.1 hydrolase 3420545 yghX 7063388 yghX Escherichia coli O127:H6 str. E2348/69 hydrolase YP_002330756.1 3419658 R 574521 CDS YP_002330757.1 215488326 7061125 3421062..3421583 1 NC_011601.1 transposase Orf1 of IS1397 3421583 7061125 E2348C_3288 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS1397 YP_002330757.1 3421062 D 574521 CDS YP_002330758.1 215488327 7062616 3421685..3422407 1 NC_011601.1 transposase Orf2 of IS1397 3422407 7062616 E2348C_3289 Escherichia coli O127:H6 str. E2348/69 transposase Orf2 of IS1397 YP_002330758.1 3421685 D 574521 CDS YP_002330759.1 215488328 7062617 complement(3423214..3423708) 1 NC_011601.1 hypothetical protein 3423708 yqhA 7062617 yqhA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330759.1 3423214 R 574521 CDS YP_002330760.1 215488329 7063195 3423899..3424783 1 NC_011601.1 oxidoreductase 3424783 yghA 7063195 yghA Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002330760.1 3423899 D 574521 CDS YP_002330761.1 215488330 7063378 complement(3424822..3425247) 1 NC_011601.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 3425247 exbD 7063378 exbD Escherichia coli O127:H6 str. E2348/69 biopolymer transport protein ExbD YP_002330761.1 3424822 R 574521 CDS YP_002330762.1 215488331 7063906 complement(3425254..3425988) 1 NC_011601.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 3425988 exbB 7063906 exbB Escherichia coli O127:H6 str. E2348/69 biopolymer transport protein ExbB YP_002330762.1 3425254 R 574521 CDS YP_002330763.1 215488332 7063905 3426240..3427427 1 NC_011601.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3427427 metC 7063905 metC Escherichia coli O127:H6 str. E2348/69 cystathionine beta-lyase YP_002330763.1 3426240 D 574521 CDS YP_002330764.1 215488333 7063758 3427567..3428226 1 NC_011601.1 hypothetical protein 3428226 yghB 7063758 yghB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330764.1 3427567 D 574521 CDS YP_002330765.1 215488334 7063379 complement(3428266..3429222) 1 NC_011601.1 DNA-binding transcriptional regulator 3429222 yqhC 7063379 yqhC Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330765.1 3428266 R 574521 CDS YP_002330766.1 215488335 7063196 3429359..3430522 1 NC_011601.1 alcohol dehydrogenase 3430522 yqhD 7063196 yqhD Escherichia coli O127:H6 str. E2348/69 alcohol dehydrogenase YP_002330766.1 3429359 D 574521 CDS YP_002330767.1 215488336 7063197 3430627..3431454 1 NC_011601.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3431454 dkgA 7063197 dkgA Escherichia coli O127:H6 str. E2348/69 2,5-diketo-D-gluconate reductase A YP_002330767.1 3430627 D 574521 CDS YP_002330768.1 215488337 7065036 3431654..3432580 1 NC_011601.1 hypothetical protein 3432580 yqhG 7065036 yqhG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330768.1 3431654 D 574521 CDS YP_002330769.1 215488338 7063198 3432631..3432888 1 NC_011601.1 outer membrane lipoprotein 3432888 yqhH 7063198 yqhH Escherichia coli O127:H6 str. E2348/69 outer membrane lipoprotein YP_002330769.1 3432631 D 574521 CDS YP_002330770.1 215488339 7063199 complement(3432930..3435149) 1 NC_011601.1 hypothetical protein 3435149 ygiQ 7063199 ygiQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330770.1 3432930 R 574521 CDS YP_002330771.1 215488340 7063396 3435401..3436150 1 NC_011601.1 regulator 3436150 7063396 E2348C_3302 Escherichia coli O127:H6 str. E2348/69 regulator YP_002330771.1 3435401 D 574521 CDS YP_002330772.1 215488341 7062618 3436473..3437945 1 NC_011601.1 mannitol dehydrogenase-family protein 3437945 7062618 E2348C_3303 Escherichia coli O127:H6 str. E2348/69 mannitol dehydrogenase-family protein YP_002330772.1 3436473 D 574521 CDS YP_002330773.1 215488342 7062619 3437942..3438958 1 NC_011601.1 zinc-binding dehydrogenase 3438958 7062619 E2348C_3304 Escherichia coli O127:H6 str. E2348/69 zinc-binding dehydrogenase YP_002330773.1 3437942 D 574521 CDS YP_002330774.1 215488343 7062620 3438969..3439979 1 NC_011601.1 malate/L-lactate dehydrogenase-family protein 3439979 7062620 E2348C_3305 Escherichia coli O127:H6 str. E2348/69 malate/L-lactate dehydrogenase-family protein YP_002330774.1 3438969 D 574521 CDS YP_002330775.1 215488344 7062621 3440052..3441035 1 NC_011601.1 TRAP-type C4-dicarboxylate transport system, periplasmic component 3441035 7062621 E2348C_3306 Escherichia coli O127:H6 str. E2348/69 TRAP-type C4-dicarboxylate transport system, periplasmic component YP_002330775.1 3440052 D 574521 CDS YP_002330776.1 215488345 7062622 3441077..3441559 1 NC_011601.1 TRAP-type C4-dicarboxylate transport system, small permease component 3441559 7062622 E2348C_3307 Escherichia coli O127:H6 str. E2348/69 TRAP-type C4-dicarboxylate transport system, small permease component YP_002330776.1 3441077 D 574521 CDS YP_002330777.1 215488346 7062623 3441570..3442874 1 NC_011601.1 TRAP-type C4-dicarboxylate transport system, large permease component 3442874 7062623 E2348C_3308 Escherichia coli O127:H6 str. E2348/69 TRAP-type C4-dicarboxylate transport system, large permease component YP_002330777.1 3441570 D 574521 CDS YP_002330778.1 215488347 7062625 complement(3442945..3444357) 1 NC_011601.1 repressor protein for FtsI 3444357 sufI 7062625 sufI Escherichia coli O127:H6 str. E2348/69 repressor protein for FtsI YP_002330778.1 3442945 R 574521 CDS YP_002330779.1 215488348 7061739 complement(3444432..3445169) 1 NC_011601.1 1-acyl-sn-glycerol-3-phosphate acyltransferase 3445169 plsC 7061739 plsC Escherichia coli O127:H6 str. E2348/69 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_002330779.1 3444432 R 574521 CDS YP_002330780.1 215488349 7060757 complement(3445404..3447662) 1 NC_011601.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 3447662 parC 7060757 parC Escherichia coli O127:H6 str. E2348/69 DNA topoisomerase IV subunit A YP_002330780.1 3445404 R 574521 CDS YP_002330781.1 215488350 7062911 complement(3447800..3449407) 1 NC_011601.1 YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; hypothetical protein 3449407 ygiS 7062911 ygiS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330781.1 3447800 R 574521 CDS YP_002330782.1 215488351 7063397 complement(3449516..3449998) 1 NC_011601.1 transcriptional regulator 3449998 ygiV 7063397 ygiV Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002330782.1 3449516 R 574521 CDS YP_002330783.1 215488352 7063398 complement(3450051..3450443) 1 NC_011601.1 hypothetical protein 3450443 ygiW 7063398 ygiW Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330783.1 3450051 R 574521 CDS YP_002330784.1 215488353 7063399 3450595..3451254 1 NC_011601.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3451254 qseB 7063399 qseB Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator QseB YP_002330784.1 3450595 D 574521 CDS YP_002330785.1 215488354 7063939 3451251..3452600 1 NC_011601.1 sensor protein QseC 3452600 qseC 7063939 qseC Escherichia coli O127:H6 str. E2348/69 sensor protein QseC YP_002330785.1 3451251 D 574521 CDS YP_002330786.1 215488355 7063940 3452710..3453291 1 NC_011601.1 NADPH quinone reductase 3453291 mdaB 7063940 mdaB Escherichia coli O127:H6 str. E2348/69 NADPH quinone reductase YP_002330786.1 3452710 D 574521 CDS YP_002330787.1 215488356 7065297 3453322..3453636 1 NC_011601.1 quinol monooxygenase 3453636 ygiN 7065297 ygiN Escherichia coli O127:H6 str. E2348/69 quinol monooxygenase YP_002330787.1 3453322 D 574521 CDS YP_002330788.1 215488357 7063395 complement(3453681..3454568) 1 NC_011601.1 transcriptional regulator 3454568 7063395 E2348C_3319 Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002330788.1 3453681 R 574521 CDS YP_002330789.1 215488358 7062626 complement(3454565..3455512) 1 NC_011601.1 ferrichrome-binding protein 3455512 7062626 E2348C_3320 Escherichia coli O127:H6 str. E2348/69 ferrichrome-binding protein YP_002330789.1 3454565 R 574521 CDS YP_002330790.1 215488359 7062627 complement(3455523..3456572) 1 NC_011601.1 permease of ferrichrome ABC transporter 3456572 7062627 E2348C_3321 Escherichia coli O127:H6 str. E2348/69 permease of ferrichrome ABC transporter YP_002330790.1 3455523 R 574521 CDS YP_002330791.1 215488360 7062628 complement(3456569..3457552) 1 NC_011601.1 permease of ferrichrome ABC transporter 3457552 7062628 E2348C_3322 Escherichia coli O127:H6 str. E2348/69 permease of ferrichrome ABC transporter YP_002330791.1 3456569 R 574521 CDS YP_002330792.1 215488361 7062629 complement(3457549..3458358) 1 NC_011601.1 ABC-type iron-siderophore transport system ATP-binding protein 3458358 7062629 E2348C_3323 Escherichia coli O127:H6 str. E2348/69 ABC-type iron-siderophore transport system ATP-binding protein YP_002330792.1 3457549 R 574521 CDS YP_002330793.1 215488362 7062630 3458732..3460873 1 NC_011601.1 ferrichrome iron receptor 3460873 7062630 E2348C_3324 Escherichia coli O127:H6 str. E2348/69 ferrichrome iron receptor YP_002330793.1 3458732 D 574521 CDS YP_002330794.1 215488363 7062631 complement(3460938..3462830) 1 NC_011601.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 3462830 parE 7062631 parE Escherichia coli O127:H6 str. E2348/69 DNA topoisomerase IV subunit B YP_002330794.1 3460938 R 574521 CDS YP_002330795.1 215488364 7062912 complement(3462859..3463440) 1 NC_011601.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase 3463440 yqiA 7062912 yqiA Escherichia coli O127:H6 str. E2348/69 esterase YP_002330795.1 3462859 R 574521 CDS YP_002330796.1 215488365 7063200 complement(3463440..3464267) 1 NC_011601.1 cyclic 3',5'-adenosine monophosphate phosphodiesterase 3464267 cpdA 7063200 cpdA Escherichia coli O127:H6 str. E2348/69 cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_002330796.1 3463440 R 574521 CDS YP_002330797.1 215488366 7062834 complement(3464292..3464714) 1 NC_011601.1 hypothetical protein 3464714 yqiB 7062834 yqiB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330797.1 3464292 R 574521 CDS YP_002330798.1 215488367 7063201 complement(3464715..3465344) 1 NC_011601.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase 3465344 nudF 7063201 nudF Escherichia coli O127:H6 str. E2348/69 ADP-ribose pyrophosphatase YP_002330798.1 3464715 R 574521 CDS YP_002330799.1 215488368 7065430 3465549..3467030 1 NC_011601.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3467030 tolC 7065430 tolC Escherichia coli O127:H6 str. E2348/69 outer membrane channel protein YP_002330799.1 3465549 D 574521 CDS YP_002330800.1 215488369 7061814 3467030..3467290 1 NC_011601.1 hypothetical protein 3467290 7061814 E2348C_3331 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330800.1 3467030 D 574521 CDS YP_002330801.1 215488370 7062632 3467178..3467849 1 NC_011601.1 hypothetical protein 3467849 ygiB 7062632 ygiB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330801.1 3467178 D 574521 CDS YP_002330802.1 215488371 7063390 3467855..3469015 1 NC_011601.1 hypothetical protein 3469015 ygiC 7063390 ygiC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330802.1 3467855 D 574521 CDS YP_002330803.1 215488372 7063391 3469500..3471296 1 NC_011601.1 arylsulfate sulfotransferase 3471296 7063391 E2348C_3334 Escherichia coli O127:H6 str. E2348/69 arylsulfate sulfotransferase YP_002330803.1 3469500 D 574521 CDS YP_002330804.1 215488373 7062633 3471314..3471982 1 NC_011601.1 disulfide isomerase, DsbA family 3471982 7062633 E2348C_3335 Escherichia coli O127:H6 str. E2348/69 disulfide isomerase, DsbA family YP_002330804.1 3471314 D 574521 CDS YP_002330805.1 215488374 7062634 3471997..3472668 1 NC_011601.1 disulfide oxidoreductase 3472668 7062634 E2348C_3336 Escherichia coli O127:H6 str. E2348/69 disulfide oxidoreductase YP_002330805.1 3471997 D 574521 CDS YP_002330806.1 215488375 7062635 complement(3472714..3473529) 1 NC_011601.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein 3473529 ygiD 7062635 ygiD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330806.1 3472714 R 574521 CDS YP_002330807.1 215488376 7063392 3473645..3474418 1 NC_011601.1 zinc transporter ZupT 3474418 zupT 7063392 zupT Escherichia coli O127:H6 str. E2348/69 zinc transporter ZupT YP_002330807.1 3473645 D 574521 CDS YP_002330808.1 215488377 7062541 complement(3474476..3474646) 1 NC_011601.1 hypothetical protein 3474646 7062541 E2348C_3339 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330808.1 3474476 R 574521 CDS YP_002330809.1 215488378 7062636 complement(3474908..3475561) 1 NC_011601.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 3475561 ribB 7062636 ribB Escherichia coli O127:H6 str. E2348/69 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_002330809.1 3474908 R 574521 CDS YP_002330810.1 215488379 7061153 3475935..3476234 1 NC_011601.1 hypothetical protein 3476234 yqiC 7061153 yqiC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330810.1 3475935 D 574521 CDS YP_002330811.1 215488380 7063202 complement(3476269..3476469) 1 NC_011601.1 Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS 3476469 glgS 7063202 glgS Escherichia coli O127:H6 str. E2348/69 glycogen synthesis protein GlgS YP_002330811.1 3476269 R 574521 CDS YP_002330812.1 215488381 7061670 3476739..3477368 1 NC_011601.1 hypothetical protein 3477368 yqiJ 7061670 yqiJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330812.1 3476739 D 574521 CDS YP_002330813.1 215488382 7063203 3477395..3479056 1 NC_011601.1 hypothetical protein 3479056 yqiK 7063203 yqiK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330813.1 3477395 D 574521 CDS YP_002330814.1 215488383 7064603 complement(3479475..3480908) 1 NC_011601.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 3480908 rfaE 7064603 rfaE Escherichia coli O127:H6 str. E2348/69 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_002330814.1 3479475 R 574521 CDS YP_002330815.1 215488384 7060782 complement(3480956..3483796) 1 NC_011601.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 3483796 glnE 7060782 glnE Escherichia coli O127:H6 str. E2348/69 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_002330815.1 3480956 R 574521 CDS YP_002330816.1 215488385 7061679 complement(3483819..3485120) 1 NC_011601.1 adenylate cyclase 3485120 ygiF 7061679 ygiF Escherichia coli O127:H6 str. E2348/69 adenylate cyclase YP_002330816.1 3483819 R 574521 CDS YP_002330817.1 215488386 7063393 3485362..3485982 1 NC_011601.1 signal transduction protein 3485982 htrG 7063393 htrG Escherichia coli O127:H6 str. E2348/69 signal transduction protein YP_002330817.1 3485362 D 574521 CDS YP_002330818.1 215488387 7062192 3486046..3487284 1 NC_011601.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3487284 cca 7062192 cca Escherichia coli O127:H6 str. E2348/69 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_002330818.1 3486046 D 574521 CDS YP_002330819.1 215488388 7064331 complement(3487364..3488185) 1 NC_011601.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 3488185 bacA 7064331 bacA Escherichia coli O127:H6 str. E2348/69 undecaprenyl pyrophosphate phosphatase YP_002330819.1 3487364 R 574521 CDS YP_002330820.1 215488389 7062490 complement(3488276..3488644) 1 NC_011601.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 3488644 folB 7062490 folB Escherichia coli O127:H6 str. E2348/69 bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase YP_002330820.1 3488276 R 574521 CDS YP_002330821.1 215488390 7061939 3488749..3489366 1 NC_011601.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 3489366 ygiH 7061939 ygiH Escherichia coli O127:H6 str. E2348/69 glycerol-3-phosphate acyltransferase PlsY YP_002330821.1 3488749 D 574521 CDS YP_002330822.1 215488391 7063394 complement(3489379..3490311) 1 NC_011601.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR 3490311 ttdR 7063394 ttdR Escherichia coli O127:H6 str. E2348/69 transcriptional activator TtdR YP_002330822.1 3489379 R 574521 CDS YP_002330823.1 215488392 7062277 3490518..3491429 1 NC_011601.1 Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3491429 ttdA 7062277 ttdA Escherichia coli O127:H6 str. E2348/69 tartrate dehydratase subunit alpha YP_002330823.1 3490518 D 574521 CDS YP_002330824.1 215488393 7062275 3491426..3492031 1 NC_011601.1 Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3492031 ttdB 7062275 ttdB Escherichia coli O127:H6 str. E2348/69 L(+)-tartrate dehydratase subunit beta YP_002330824.1 3491426 D 574521 CDS YP_002330825.1 215488394 7062276 3492079..3493542 1 NC_011601.1 tartrate: succinate antiporter 3493542 ttdT 7062276 ttdT Escherichia coli O127:H6 str. E2348/69 tartrate: succinate antiporter YP_002330825.1 3492079 D 574521 CDS YP_002330826.1 215488395 7062278 complement(3493585..3494598) 1 NC_011601.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 3494598 ygjD 7062278 ygjD Escherichia coli O127:H6 str. E2348/69 DNA-binding/iron metalloprotein/AP endonuclease YP_002330826.1 3493585 R 574521 CDS YP_002330827.1 215488396 7063400 3494836..3495051 1 NC_011601.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3495051 rpsU 7063400 rpsU Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S21 YP_002330827.1 3494836 D 574521 CDS YP_002330828.1 215488397 7061893 3495162..3496907 1 NC_011601.1 synthesizes RNA primers at the replication forks; DNA primase 3496907 dnaG 7061893 dnaG Escherichia coli O127:H6 str. E2348/69 DNA primase YP_002330828.1 3495162 D 574521 CDS YP_002330829.1 215488398 7065048 3497102..3498943 1 NC_011601.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3498943 rpoD 7065048 rpoD Escherichia coli O127:H6 str. E2348/69 RNA polymerase sigma factor RpoD YP_002330829.1 3497102 D 574521 CDS YP_002330830.1 215488399 7061866 3499002..3499565 1 NC_011601.1 hypothetical protein 3499565 7061866 E2348C_3361 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330830.1 3499002 D 574521 CDS YP_002330831.1 215488400 7063527 complement(3500372..3501136) 1 NC_011601.1 siderophore interacting protein 3501136 yqjH 7063527 yqjH Escherichia coli O127:H6 str. E2348/69 siderophore interacting protein YP_002330831.1 3500372 R 574521 CDS YP_002330832.1 215488401 7063212 3501424..3502047 1 NC_011601.1 transcriptional regulator 3502047 yqjI 7063212 yqjI Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002330832.1 3501424 D 574521 CDS YP_002330833.1 215488402 7063213 complement(3502076..3503596) 1 NC_011601.1 fused signal transducer for aerotaxis sensory component/methyl accepting chemotaxis component 3503596 aer 7063213 aer Escherichia coli O127:H6 str. E2348/69 fused signal transducer for aerotaxis sensory component/methyl accepting chemotaxis component YP_002330833.1 3502076 R 574521 CDS YP_002330834.1 215488403 7062414 3504014..3505393 1 NC_011601.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3505393 ygjG 7062414 ygjG Escherichia coli O127:H6 str. E2348/69 putrescine--2-oxoglutarate aminotransferase YP_002330834.1 3504014 D 574521 CDS YP_002330835.1 215488404 7063401 complement(3505435..3505767) 1 NC_011601.1 hypothetical protein 3505767 ygjH 7063401 ygjH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330835.1 3505435 R 574521 CDS YP_002330836.1 215488405 7063402 3505986..3506969 1 NC_011601.1 DNA-binding transcriptional repressor EbgR 3506969 ebgR 7063402 ebgR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor EbgR YP_002330836.1 3505986 D 574521 CDS YP_002330837.1 215488406 7065082 3507153..3510245 1 NC_011601.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3510245 ebgA 7065082 ebgA Escherichia coli O127:H6 str. E2348/69 cryptic beta-D-galactosidase subunit alpha YP_002330837.1 3507153 D 574521 CDS YP_002330838.1 215488407 7065080 3510242..3510691 1 NC_011601.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3510691 ebgC 7065080 ebgC Escherichia coli O127:H6 str. E2348/69 cryptic beta-D-galactosidase subunit beta YP_002330838.1 3510242 D 574521 CDS YP_002330839.1 215488408 7065081 3510754..3512187 1 NC_011601.1 transporter 3512187 ygjI 7065081 ygjI Escherichia coli O127:H6 str. E2348/69 transporter YP_002330839.1 3510754 D 574521 CDS YP_002330840.1 215488409 7063403 3512321..3513391 1 NC_011601.1 hypothetical protein 3513391 ygjJ 7063403 ygjJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330840.1 3512321 D 574521 CDS YP_002330841.1 215488410 7063404 3513408..3515759 1 NC_011601.1 glycosyl hydrolase 3515759 ygjK 7063404 ygjK Escherichia coli O127:H6 str. E2348/69 glycosyl hydrolase YP_002330841.1 3513408 D 574521 CDS YP_002330842.1 215488411 7063405 3516083..3518101 1 NC_011601.1 2,4-dienoyl-CoA reductase 3518101 fadH 7063405 fadH Escherichia coli O127:H6 str. E2348/69 2,4-dienoyl-CoA reductase YP_002330842.1 3516083 D 574521 CDS YP_002330843.1 215488412 7062075 complement(3518146..3518562) 1 NC_011601.1 DNA-binding transcriptional regulator 3518562 ygjM 7062075 ygjM Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330843.1 3518146 R 574521 CDS YP_002330844.1 215488413 7063406 complement(3518833..3519969) 1 NC_011601.1 methyltransferase small domain 3519969 rlmG 7063406 rlmG Escherichia coli O127:H6 str. E2348/69 methyltransferase small domain YP_002330844.1 3518833 R 574521 CDS YP_002330845.1 215488414 7060834 3520054..3520557 1 NC_011601.1 metal dependent hydrolase 3520557 ygjP 7060834 ygjP Escherichia coli O127:H6 str. E2348/69 metal dependent hydrolase YP_002330845.1 3520054 D 574521 CDS YP_002330846.1 215488415 7063407 3520634..3521326 1 NC_011601.1 thioredoxin-like protein 3521326 ygjQ 7063407 ygjQ Escherichia coli O127:H6 str. E2348/69 thioredoxin-like protein YP_002330846.1 3520634 D 574521 CDS YP_002330847.1 215488416 7063408 3521405..3522391 1 NC_011601.1 NAD(P)-binding dehydrogenase 3522391 ygjR 7063408 ygjR Escherichia coli O127:H6 str. E2348/69 NAD(P)-binding dehydrogenase YP_002330847.1 3521405 D 574521 CDS YP_002330848.1 215488417 7061326 3522674..3523639 1 NC_011601.1 hypothetical protein 3523639 alx 7061326 alx Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330848.1 3522674 D 574521 CDS YP_002330849.1 215488418 7061126 3523876..3525249 1 NC_011601.1 transposase of ISEc13 3525249 7061126 E2348C_3381 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002330849.1 3523876 D 574521 CDS YP_002330850.1 215488419 7062638 3525523..3526767 1 NC_011601.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3526767 sstT 7062638 sstT Escherichia coli O127:H6 str. E2348/69 serine/threonine transporter SstT YP_002330850.1 3525523 D 574521 CDS YP_002330851.1 215488420 7062769 complement(3526771..3527322) 1 NC_011601.1 hypothetical protein 3527322 ygjV 7062769 ygjV Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330851.1 3526771 R 574521 CDS YP_002330852.1 215488421 7063410 complement(3527405..3528892) 1 NC_011601.1 altronate hydrolase 3528892 uxaA 7063410 uxaA Escherichia coli O127:H6 str. E2348/69 altronate hydrolase YP_002330852.1 3527405 R 574521 CDS YP_002330853.1 215488422 7062345 complement(3528907..3530319) 1 NC_011601.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 3530319 uxaC 7062345 uxaC Escherichia coli O127:H6 str. E2348/69 glucuronate isomerase YP_002330853.1 3528907 R 574521 CDS YP_002330854.1 215488423 7062347 3530678..3532096 1 NC_011601.1 hexuronate transporter 3532096 exuT 7062347 exuT Escherichia coli O127:H6 str. E2348/69 hexuronate transporter YP_002330854.1 3530678 D 574521 CDS YP_002330855.1 215488424 7062061 3532226..3533002 1 NC_011601.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3533002 exuR 7062061 exuR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor ExuR YP_002330855.1 3532226 D 574521 CDS YP_002330856.1 215488425 7062059 3533347..3534009 1 NC_011601.1 hypothetical protein 3534009 yqjA 7062059 yqjA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330856.1 3533347 D 574521 CDS YP_002330857.1 215488426 7063205 3534013..3534396 1 NC_011601.1 hypothetical protein 3534396 yqjB 7063205 yqjB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330857.1 3534013 D 574521 CDS YP_002330858.1 215488427 7063206 3534543..3534911 1 NC_011601.1 hypothetical protein 3534911 yqjC 7063206 yqjC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330858.1 3534543 D 574521 CDS YP_002330859.1 215488428 7063207 3534949..3535254 1 NC_011601.1 hypothetical protein 3535254 yqjD 7063207 yqjD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330859.1 3534949 D 574521 CDS YP_002330860.1 215488429 7063208 3535257..3535661 1 NC_011601.1 hypothetical protein 3535661 yqjE 7063208 yqjE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330860.1 3535257 D 574521 CDS YP_002330861.1 215488430 7063209 3535651..3535950 1 NC_011601.1 hypothetical protein 3535950 yqjK 7063209 yqjK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330861.1 3535651 D 574521 CDS YP_002330862.1 215488431 7063214 3536137..3536529 1 NC_011601.1 quinol oxidase subunit 3536529 yqjF 7063214 yqjF Escherichia coli O127:H6 str. E2348/69 quinol oxidase subunit YP_002330862.1 3536137 D 574521 CDS YP_002330863.1 215488432 7063210 3536599..3537585 1 NC_011601.1 S-transferase 3537585 yqjG 7063210 yqjG Escherichia coli O127:H6 str. E2348/69 S-transferase YP_002330863.1 3536599 D 574521 CDS YP_002330864.1 215488433 7063211 3537868..3538236 1 NC_011601.1 hypothetical protein 3538236 yhaH 7063211 yhaH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330864.1 3537868 D 574521 CDS YP_002330865.1 215488434 7063411 complement(3538270..3539166) 1 NC_011601.1 DNA-binding transcriptional regulator 3539166 yhaJ 7063411 yhaJ Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330865.1 3538270 R 574521 CDS YP_002330866.1 215488435 7063412 3539271..3539972 1 NC_011601.1 pirin 3539972 yhaK 7063412 yhaK Escherichia coli O127:H6 str. E2348/69 pirin YP_002330866.1 3539271 D 574521 CDS YP_002330867.1 215488436 7063413 3539995..3540159 1 NC_011601.1 hypothetical protein 3540159 yhaL 7063413 yhaL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330867.1 3539995 D 574521 CDS YP_002330868.1 215488437 7063414 complement(3540291..3541601) 1 NC_011601.1 hypothetical protein 3541601 yhaM 7063414 yhaM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330868.1 3540291 R 574521 CDS YP_002330869.1 215488438 7063415 complement(3541629..3542960) 1 NC_011601.1 transporter 3542960 yhaO 7063415 yhaO Escherichia coli O127:H6 str. E2348/69 transporter YP_002330869.1 3541629 R 574521 CDS YP_002330870.1 215488439 7063416 complement(3543238..3544602) 1 NC_011601.1 L-serine dehydratase 3 3544602 tdcG 7063416 tdcG Escherichia coli O127:H6 str. E2348/69 L-serine dehydratase 3 YP_002330870.1 3543238 R 574521 CDS YP_002330871.1 215488440 7061771 complement(3544674..3545063) 1 NC_011601.1 hypothetical protein 3545063 tdcF 7061771 tdcF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330871.1 3544674 R 574521 CDS YP_002330872.1 215488441 7061770 complement(3545077..3547371) 1 NC_011601.1 pyruvate formate-lyase 4/2-ketobutyrate formate-lyase 3547371 tdcE 7061770 tdcE Escherichia coli O127:H6 str. E2348/69 pyruvate formate-lyase 4/2-ketobutyrate formate-lyase YP_002330872.1 3545077 R 574521 CDS YP_002330873.1 215488442 7061769 complement(3547405..3548613) 1 NC_011601.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 3548613 tdcD 7061769 tdcD Escherichia coli O127:H6 str. E2348/69 propionate/acetate kinase YP_002330873.1 3547405 R 574521 CDS YP_002330874.1 215488443 7061768 complement(3548639..3549970) 1 NC_011601.1 involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC 3549970 tdcC 7061768 tdcC Escherichia coli O127:H6 str. E2348/69 threonine/serine transporter TdcC YP_002330874.1 3548639 R 574521 CDS YP_002330875.1 215488444 7061767 complement(3549992..3550981) 1 NC_011601.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 3550981 tdcB 7061767 tdcB Escherichia coli O127:H6 str. E2348/69 threonine dehydratase YP_002330875.1 3549992 R 574521 CDS YP_002330876.1 215488445 7061766 complement(3551080..3552018) 1 NC_011601.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA 3552018 tdcA 7061766 tdcA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator TdcA YP_002330876.1 3551080 R 574521 CDS YP_002330877.1 215488446 7061765 3552333..3552551 1 NC_011601.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3552551 tdcR 7061765 tdcR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator TdcR YP_002330877.1 3552333 D 574521 CDS YP_002330878.1 215488447 7060857 complement(3553517..3554662) 1 NC_011601.1 glycerate kinase 3554662 garK 7060857 garK Escherichia coli O127:H6 str. E2348/69 glycerate kinase YP_002330878.1 3553517 R 574521 CDS YP_002330879.1 215488448 7061628 complement(3554759..3555649) 1 NC_011601.1 catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase 3555649 garR 7061628 garR Escherichia coli O127:H6 str. E2348/69 tartronate semialdehyde reductase YP_002330879.1 3554759 R 574521 CDS YP_002330880.1 215488449 7061631 complement(3555679..3556449) 1 NC_011601.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase 3556449 garL 7061631 garL Escherichia coli O127:H6 str. E2348/69 alpha-dehydro-beta-deoxy-D-glucarate aldolase YP_002330880.1 3555679 R 574521 CDS YP_002330881.1 215488450 7061629 complement(3556465..3557799) 1 NC_011601.1 (D)-galactarate transporter 3557799 garP 7061629 garP Escherichia coli O127:H6 str. E2348/69 (D)-galactarate transporter YP_002330881.1 3556465 R 574521 CDS YP_002330882.1 215488451 7061630 3558174..3559745 1 NC_011601.1 (D)-galactarate dehydrogenase 3559745 garD 7061630 garD Escherichia coli O127:H6 str. E2348/69 (D)-galactarate dehydrogenase YP_002330882.1 3558174 D 574521 CDS YP_002330883.1 215488452 7061627 complement(3559797..3560621) 1 NC_011601.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR 3560621 agaR 7061627 agaR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator AgaR YP_002330883.1 3559797 R 574521 CDS YP_002330884.1 215488453 7062421 3560870..3562150 1 NC_011601.1 tagatose 6-phosphate aldolase 1, kbaZ subunit 3562150 kbaZ 7062421 kbaZ Escherichia coli O127:H6 str. E2348/69 tagatose 6-phosphate aldolase 1, kbaZ subunit YP_002330884.1 3560870 D 574521 CDS YP_002330885.1 215488454 7063566 3562173..3562646 1 NC_011601.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3562646 agaV 7063566 agaV Escherichia coli O127:H6 str. E2348/69 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_002330885.1 3562173 D 574521 CDS YP_002330886.1 215488455 7062423 3562657..3563442 1 NC_011601.1 N-acetylgalactosamine-specific enzyme IIC component of PTS 3563442 agaW 7062423 agaW Escherichia coli O127:H6 str. E2348/69 N-acetylgalactosamine-specific enzyme IIC component of PTS YP_002330886.1 3562657 D 574521 CDS YP_002330887.1 215488456 7062424 3563432..3564310 1 NC_011601.1 N-acetylgalactosamine-specific PTS system enzyme IID component 3564310 7062424 E2348C_3419 Escherichia coli O127:H6 str. E2348/69 N-acetylgalactosamine-specific PTS system enzyme IID component YP_002330887.1 3563432 D 574521 CDS YP_002330888.1 215488457 7062639 3564328..3564762 1 NC_011601.1 N-acetyl-galactosamine/galactosamine PTS system enzyme IIA component 3564762 7062639 E2348C_3420 Escherichia coli O127:H6 str. E2348/69 N-acetyl-galactosamine/galactosamine PTS system enzyme IIA component YP_002330888.1 3564328 D 574521 CDS YP_002330889.1 215488458 7062640 3564759..3565892 1 NC_011601.1 N-acetylgalactosamine-6-sulfatase 3565892 agaA 7062640 agaA Escherichia coli O127:H6 str. E2348/69 N-acetylgalactosamine-6-sulfatase YP_002330889.1 3564759 D 574521 CDS YP_002330890.1 215488459 7062416 3566241..3567395 1 NC_011601.1 tagatose-6-phosphate ketose/aldose isomerase 3567395 agaS 7062416 agaS Escherichia coli O127:H6 str. E2348/69 tagatose-6-phosphate ketose/aldose isomerase YP_002330890.1 3566241 D 574521 CDS YP_002330891.1 215488460 7062422 3567408..3568268 1 NC_011601.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3568268 kbaY 7062422 kbaY Escherichia coli O127:H6 str. E2348/69 tagatose-bisphosphate aldolase YP_002330891.1 3567408 D 574521 CDS YP_002330892.1 215488461 7063565 3568435..3568911 1 NC_011601.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3568911 agaB 7063565 agaB Escherichia coli O127:H6 str. E2348/69 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_002330892.1 3568435 D 574521 CDS YP_002330893.1 215488462 7062417 3568950..3569753 1 NC_011601.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 3569753 agaC 7062417 agaC Escherichia coli O127:H6 str. E2348/69 PTS system N-acetylgalactosamine-specific transporter subunit IIC YP_002330893.1 3568950 D 574521 CDS YP_002330894.1 215488463 7062418 3569743..3570534 1 NC_011601.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 3570534 agaD 7062418 agaD Escherichia coli O127:H6 str. E2348/69 PTS system N-acetylgalactosamine-specific transporter subunit IID YP_002330894.1 3569743 D 574521 CDS YP_002330895.1 215488464 7062419 3570589..3571302 1 NC_011601.1 galactosamine-6-phosphate isomerase 3571302 agaI 7062419 agaI Escherichia coli O127:H6 str. E2348/69 galactosamine-6-phosphate isomerase YP_002330895.1 3570589 D 574521 CDS YP_002330896.1 215488465 7062420 complement(3571352..3572215) 1 NC_011601.1 methyltransferase 3572215 yraL 7062420 yraL Escherichia coli O127:H6 str. E2348/69 methyltransferase YP_002330896.1 3571352 R 574521 CDS YP_002330897.1 215488466 7063215 3572280..3574316 1 NC_011601.1 hypothetical protein 3574316 yraM 7063215 yraM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330897.1 3572280 D 574521 CDS YP_002330898.1 215488467 7063216 3574274..3574669 1 NC_011601.1 hypothetical protein 3574669 yraN 7063216 yraN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330898.1 3574274 D 574521 CDS YP_002330899.1 215488468 7063217 3574689..3575279 1 NC_011601.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3575279 diaA 7063217 diaA Escherichia coli O127:H6 str. E2348/69 DnaA initiator-associating protein DiaA YP_002330899.1 3574689 D 574521 CDS YP_002330900.1 215488469 7065025 3575289..3575864 1 NC_011601.1 hypothetical protein 3575864 yraP 7065025 yraP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330900.1 3575289 D 574521 CDS YP_002330901.1 215488470 7063218 complement(3575977..3577023) 1 NC_011601.1 permease 3577023 yraQ 7063218 yraQ Escherichia coli O127:H6 str. E2348/69 permease YP_002330901.1 3575977 R 574521 CDS YP_002330902.1 215488471 7063219 complement(3577096..3577731) 1 NC_011601.1 nucleoside-diphosphate-sugarepimerase 3577731 yraR 7063219 yraR Escherichia coli O127:H6 str. E2348/69 nucleoside-diphosphate-sugarepimerase YP_002330902.1 3577096 R 574521 CDS YP_002330903.1 215488472 7063220 complement(3577773..3578195) 1 NC_011601.1 hypothetical protein 3578195 yhbP 7063220 yhbP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330903.1 3577773 R 574521 CDS YP_002330904.1 215488473 7063420 3578246..3578548 1 NC_011601.1 GIY-YIG nuclease superfamily protein 3578548 yhbQ 7063420 yhbQ Escherichia coli O127:H6 str. E2348/69 GIY-YIG nuclease superfamily protein YP_002330904.1 3578246 D 574521 CDS YP_002330905.1 215488474 7063421 complement(3578535..3579038) 1 NC_011601.1 acyltransferase 3579038 yhbS 7063421 yhbS Escherichia coli O127:H6 str. E2348/69 acyltransferase YP_002330905.1 3578535 R 574521 CDS YP_002330906.1 215488475 7063422 complement(3579032..3579556) 1 NC_011601.1 lipid carrier protein 3579556 yhbT 7063422 yhbT Escherichia coli O127:H6 str. E2348/69 lipid carrier protein YP_002330906.1 3579032 R 574521 CDS YP_002330907.1 215488476 7063423 3579765..3580760 1 NC_011601.1 peptidase (collagenase-like) 3580760 yhbU 7063423 yhbU Escherichia coli O127:H6 str. E2348/69 peptidase (collagenase-like) YP_002330907.1 3579765 D 574521 CDS YP_002330908.1 215488477 7064446 3580769..3581647 1 NC_011601.1 protease 3581647 yhbV 7064446 yhbV Escherichia coli O127:H6 str. E2348/69 protease YP_002330908.1 3580769 D 574521 CDS YP_002330909.1 215488478 7064605 3581728..3582735 1 NC_011601.1 hypothetical protein 3582735 yhbW 7064605 yhbW Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330909.1 3581728 D 574521 CDS YP_002330910.1 215488479 7064606 complement(3582853..3584097) 1 NC_011601.1 tryptophan transporter of high affinity; tryptophan permease 3584097 mtr 7064606 mtr Escherichia coli O127:H6 str. E2348/69 tryptophan permease YP_002330910.1 3582853 R 574521 CDS YP_002330911.1 215488480 7060882 complement(3584251..3586140) 1 NC_011601.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD 3586140 deaD 7060882 deaD Escherichia coli O127:H6 str. E2348/69 ATP-dependent RNA helicase DeaD YP_002330911.1 3584251 R 574521 CDS YP_002330912.1 215488481 7065239 complement(3586320..3587204) 1 NC_011601.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 3587204 nlpI 7065239 nlpI Escherichia coli O127:H6 str. E2348/69 lipoprotein NlpI YP_002330912.1 3586320 R 574521 CDS YP_002330913.1 215488482 7065405 complement(3587313..3589448) 1 NC_011601.1 polynucleotide phosphorylase 3589448 pnp 7065405 pnp Escherichia coli O127:H6 str. E2348/69 polynucleotide phosphorylase YP_002330913.1 3587313 R 574521 CDS YP_002330914.1 215488483 7061327 complement(3589695..3589964) 1 NC_011601.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3589964 rpsO 7061327 rpsO Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S15 YP_002330914.1 3589695 R 574521 CDS YP_002330915.1 215488484 7061154 complement(3590113..3591057) 1 NC_011601.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3591057 truB 7061154 truB Escherichia coli O127:H6 str. E2348/69 tRNA pseudouridine synthase B YP_002330915.1 3590113 R 574521 CDS YP_002330916.1 215488485 7062264 complement(3591057..3591458) 1 NC_011601.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3591458 rbfA 7062264 rbfA Escherichia coli O127:H6 str. E2348/69 ribosome-binding factor A YP_002330916.1 3591057 R 574521 CDS YP_002330917.1 215488486 7063952 complement(3591622..3594294) 1 NC_011601.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3594294 infB 7063952 infB Escherichia coli O127:H6 str. E2348/69 translation initiation factor IF-2 YP_002330917.1 3591622 R 574521 CDS YP_002330918.1 215488487 7063543 complement(3594319..3595806) 1 NC_011601.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 3595806 nusA 7063543 nusA Escherichia coli O127:H6 str. E2348/69 transcription elongation factor NusA YP_002330918.1 3594319 R 574521 CDS YP_002330919.1 215488488 7062868 complement(3595834..3596256) 1 NC_011601.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3596256 yhbC 7062868 yhbC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330919.1 3595834 R 574521 CDS YP_002330920.1 215488489 7063774 3596917..3598260 1 NC_011601.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3598260 argG 7063774 argG Escherichia coli O127:H6 str. E2348/69 argininosuccinate synthase YP_002330920.1 3596917 D 574521 CDS YP_002330921.1 215488490 7061370 complement(3598268..3599893) 1 NC_011601.1 hydrolase, inner membrane 3599893 yhbX 7061370 yhbX Escherichia coli O127:H6 str. E2348/69 hydrolase, inner membrane YP_002330921.1 3598268 R 574521 CDS YP_002330922.1 215488491 7061532 complement(3600451..3600783) 1 NC_011601.1 preprotein translocase subunit SecG 3600783 secG 7061532 secG Escherichia coli O127:H6 str. E2348/69 preprotein translocase subunit SecG YP_002330922.1 3600451 R 574521 CDS YP_002330923.1 215488492 7065357 complement(3601011..3602348) 1 NC_011601.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 3602348 glmM 7065357 glmM Escherichia coli O127:H6 str. E2348/69 phosphoglucosamine mutase YP_002330923.1 3601011 R 574521 CDS YP_002330924.1 215488493 7061673 complement(3602341..3603189) 1 NC_011601.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase 3603189 folP 7061673 folP Escherichia coli O127:H6 str. E2348/69 dihydropteroate synthase YP_002330924.1 3602341 R 574521 CDS YP_002330925.1 215488494 7061945 complement(3603279..3605213) 1 NC_011601.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease 3605213 hflB 7061945 hflB Escherichia coli O127:H6 str. E2348/69 ATP-dependent metalloprotease YP_002330925.1 3603279 R 574521 CDS YP_002330926.1 215488495 7064304 complement(3605313..3605942) 1 NC_011601.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase 3605942 rrmJ 7064304 rrmJ Escherichia coli O127:H6 str. E2348/69 23S rRNA methyltransferase YP_002330926.1 3605313 R 574521 CDS YP_002330927.1 215488496 7064541 3606068..3606361 1 NC_011601.1 RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3606361 yhbY 7064541 yhbY Escherichia coli O127:H6 str. E2348/69 RNA-binding protein YhbY YP_002330927.1 3606068 D 574521 CDS YP_002330928.1 215488497 7064608 complement(3606517..3606993) 1 NC_011601.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 3606993 greA 7064608 greA Escherichia coli O127:H6 str. E2348/69 transcription elongation factor GreA YP_002330928.1 3606517 R 574521 CDS YP_002330929.1 215488498 7064239 3607241..3608674 1 NC_011601.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 3608674 dacB 7064239 dacB Escherichia coli O127:H6 str. E2348/69 D-alanyl-D-alanine carboxypeptidase YP_002330929.1 3607241 D 574521 CDS YP_002330930.1 215488499 7065213 complement(3608715..3609887) 1 NC_011601.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 3609887 obgE 7065213 obgE Escherichia coli O127:H6 str. E2348/69 GTPase ObgE YP_002330930.1 3608715 R 574521 CDS YP_002330931.1 215488500 7062871 complement(3609903..3610868) 1 NC_011601.1 hypothetical protein 3610868 yhbE 7062871 yhbE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330931.1 3609903 R 574521 CDS YP_002330932.1 215488501 7063418 complement(3610995..3611252) 1 NC_011601.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 3611252 rpmA 7063418 rpmA Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L27 YP_002330932.1 3610995 R 574521 CDS YP_002330933.1 215488502 7061853 complement(3611273..3611584) 1 NC_011601.1 50S ribosomal protein L21 3611584 rplU 7061853 rplU Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L21 YP_002330933.1 3611273 R 574521 CDS YP_002330934.1 215488503 7061848 3611843..3612814 1 NC_011601.1 octaprenyl diphosphate synthase 3612814 ispB 7061848 ispB Escherichia coli O127:H6 str. E2348/69 octaprenyl diphosphate synthase YP_002330934.1 3611843 D 574521 CDS YP_002330935.1 215488504 7063552 3613048..3613326 1 NC_011601.1 activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3613326 sfsB 7063552 sfsB Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator Nlp YP_002330935.1 3613048 D 574521 CDS YP_002330936.1 215488505 7062710 complement(3613374..3614633) 1 NC_011601.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 3614633 murA 7062710 murA Escherichia coli O127:H6 str. E2348/69 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002330936.1 3613374 R 574521 CDS YP_002330937.1 215488506 7060887 complement(3614688..3614942) 1 NC_011601.1 DNA-binding transcriptional regulator 3614942 yrbA 7060887 yrbA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330937.1 3614688 R 574521 CDS YP_002330938.1 215488507 7063221 complement(3615102..3615395) 1 NC_011601.1 hypothetical protein 3615395 yrbB 7063221 yrbB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330938.1 3615102 R 574521 CDS YP_002330939.1 215488508 7063222 complement(3615395..3616030) 1 NC_011601.1 ABC-type organic solvent transporter 3616030 yrbC 7063222 yrbC Escherichia coli O127:H6 str. E2348/69 ABC-type organic solvent transporter YP_002330939.1 3615395 R 574521 CDS YP_002330940.1 215488509 7063223 complement(3616049..3616600) 1 NC_011601.1 ABC-type organic solvent transporter 3616600 yrbD 7063223 yrbD Escherichia coli O127:H6 str. E2348/69 ABC-type organic solvent transporter YP_002330940.1 3616049 R 574521 CDS YP_002330941.1 215488510 7063224 complement(3616605..3617387) 1 NC_011601.1 toluene transporter subunit: membrane component of ABC superfamily 3617387 yrbE 7063224 yrbE Escherichia coli O127:H6 str. E2348/69 toluene transporter subunit: membrane component of ABC superfamily YP_002330941.1 3616605 R 574521 CDS YP_002330942.1 215488511 7063225 complement(3617395..3618204) 1 NC_011601.1 ATP-binding subunit of a ABC toluene efflux transporter; ABC transporter ATP-binding protein 3618204 yrbF 7063225 yrbF Escherichia coli O127:H6 str. E2348/69 ABC transporter ATP-binding protein YP_002330942.1 3617395 R 574521 CDS YP_002330943.1 215488512 7063226 3618414..3619391 1 NC_011601.1 YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 3619391 yrbG 7063226 yrbG Escherichia coli O127:H6 str. E2348/69 calcium/sodium:proton antiporter YP_002330943.1 3618414 D 574521 CDS YP_002330944.1 215488513 7063227 3619405..3620391 1 NC_011601.1 D-arabinose 5-phosphate isomerase 3620391 kdsD 7063227 kdsD Escherichia coli O127:H6 str. E2348/69 D-arabinose 5-phosphate isomerase YP_002330944.1 3619405 D 574521 CDS YP_002330945.1 215488514 7063581 3620412..3620978 1 NC_011601.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3620978 kdsC 7063581 kdsC Escherichia coli O127:H6 str. E2348/69 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_002330945.1 3620412 D 574521 CDS YP_002330946.1 215488515 7063580 3620975..3621550 1 NC_011601.1 hypothetical protein 3621550 yrbK 7063580 yrbK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330946.1 3620975 D 574521 CDS YP_002330947.1 215488516 7063228 3621519..3622076 1 NC_011601.1 LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3622076 lptA 7063228 lptA Escherichia coli O127:H6 str. E2348/69 lipopolysaccharide transport periplasmic protein LptA YP_002330947.1 3621519 D 574521 CDS YP_002330948.1 215488517 7061570 3622083..3622808 1 NC_011601.1 ABC transporter ATP-binding protein 3622808 lptB 7061570 lptB Escherichia coli O127:H6 str. E2348/69 ABC transporter ATP-binding protein YP_002330948.1 3622083 D 574521 CDS YP_002330949.1 215488518 7061571 3622856..3624289 1 NC_011601.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3624289 rpoN 7061571 rpoN Escherichia coli O127:H6 str. E2348/69 RNA polymerase factor sigma-54 YP_002330949.1 3622856 D 574521 CDS YP_002330950.1 215488519 7061869 3624312..3624599 1 NC_011601.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 3624599 hpf 7061869 hpf Escherichia coli O127:H6 str. E2348/69 sigma(54) modulation protein YP_002330950.1 3624312 D 574521 CDS YP_002330951.1 215488520 7062176 3624717..3625208 1 NC_011601.1 PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3625208 ptsN 7062176 ptsN Escherichia coli O127:H6 str. E2348/69 PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN YP_002330951.1 3624717 D 574521 CDS YP_002330952.1 215488521 7063909 3625254..3626108 1 NC_011601.1 hypothetical protein 3626108 yhbJ 7063909 yhbJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330952.1 3625254 D 574521 CDS YP_002330953.1 215488522 7063419 3626105..3626377 1 NC_011601.1 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3626377 npr 7063419 npr Escherichia coli O127:H6 str. E2348/69 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) YP_002330953.1 3626105 D 574521 CDS YP_002330954.1 215488523 7065408 3626590..3627222 1 NC_011601.1 hypothetical protein 3627222 yrbL 7065408 yrbL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330954.1 3626590 D 574521 CDS YP_002330955.1 215488524 7063229 complement(3627219..3627947) 1 NC_011601.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 3627947 mtgA 7063229 mtgA Escherichia coli O127:H6 str. E2348/69 monofunctional biosynthetic peptidoglycan transglycosylase YP_002330955.1 3627219 R 574521 CDS YP_002330956.1 215488525 7060878 complement(3627944..3628597) 1 NC_011601.1 isoprenoid biosynthesis protein with amidotransferase-like domain 3628597 elbB 7060878 elbB Escherichia coli O127:H6 str. E2348/69 isoprenoid biosynthesis protein with amidotransferase-like domain YP_002330956.1 3627944 R 574521 CDS YP_002330957.1 215488526 7064604 complement(3628827..3631163) 1 NC_011601.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB 3631163 arcB 7064604 arcB Escherichia coli O127:H6 str. E2348/69 aerobic respiration control sensor protein ArcB YP_002330957.1 3628827 R 574521 CDS YP_002330958.1 215488527 7061364 complement(3631259..3632188) 1 NC_011601.1 Fe-S oxidoreductase 3632188 yhcC 7061364 yhcC Escherichia coli O127:H6 str. E2348/69 Fe-S oxidoreductase YP_002330958.1 3631259 R 574521 CDS YP_002330959.1 215488528 7064610 3632770..3637323 1 NC_011601.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3637323 gltB 7064610 gltB Escherichia coli O127:H6 str. E2348/69 glutamate synthase subunit alpha YP_002330959.1 3632770 D 574521 CDS YP_002330960.1 215488529 7061705 3637336..3638754 1 NC_011601.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3638754 gltD 7061705 gltD Escherichia coli O127:H6 str. E2348/69 glutamate synthase subunit beta YP_002330960.1 3637336 D 574521 CDS YP_002330961.1 215488530 7061706 complement(3638822..3639286) 1 NC_011601.1 hypothetical protein 3639286 yhcH 7061706 yhcH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330961.1 3638822 R 574521 CDS YP_002330962.1 215488531 7064611 complement(3639283..3640158) 1 NC_011601.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 3640158 nanK 7064611 nanK Escherichia coli O127:H6 str. E2348/69 N-acetylmannosamine kinase YP_002330962.1 3639283 R 574521 CDS YP_002330963.1 215488532 7060921 complement(3640155..3640844) 1 NC_011601.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 3640844 nanE 7060921 nanE Escherichia coli O127:H6 str. E2348/69 N-acetylmannosamine-6-phosphate 2-epimerase YP_002330963.1 3640155 R 574521 CDS YP_002330964.1 215488533 7060920 complement(3640892..3642382) 1 NC_011601.1 sialic acid transporter 3642382 nanT 7060920 nanT Escherichia coli O127:H6 str. E2348/69 sialic acid transporter YP_002330964.1 3640892 R 574521 CDS YP_002330965.1 215488534 7060923 complement(3642491..3643384) 1 NC_011601.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 3643384 nanA 7060923 nanA Escherichia coli O127:H6 str. E2348/69 N-acetylneuraminate lyase YP_002330965.1 3642491 R 574521 CDS YP_002330966.1 215488535 7060918 complement(3643506..3644297) 1 NC_011601.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR 3644297 nanR 7060918 nanR Escherichia coli O127:H6 str. E2348/69 transcriptional regulator NanR YP_002330966.1 3643506 R 574521 CDS YP_002330967.1 215488536 7060922 complement(3644405..3644902) 1 NC_011601.1 ClpXP protease specificity-enhancing factor 3644902 sspB 7060922 sspB Escherichia coli O127:H6 str. E2348/69 ClpXP protease specificity-enhancing factor YP_002330967.1 3644405 R 574521 CDS YP_002330968.1 215488537 7062766 complement(3644908..3645546) 1 NC_011601.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A 3645546 sspA 7062766 sspA Escherichia coli O127:H6 str. E2348/69 stringent starvation protein A YP_002330968.1 3644908 R 574521 CDS YP_002330969.1 215488538 7062765 complement(3645941..3646333) 1 NC_011601.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3646333 rpsI 7062765 rpsI Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S9 YP_002330969.1 3645941 R 574521 CDS YP_002330970.1 215488539 7061881 complement(3646349..3646777) 1 NC_011601.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3646777 rplM 7061881 rplM Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L13 YP_002330970.1 3646349 R 574521 CDS YP_002330971.1 215488540 7061840 complement(3646997..3648124) 1 NC_011601.1 hypothetical protein 3648124 yhcM 7061840 yhcM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330971.1 3646997 R 574521 CDS YP_002330972.1 215488541 7064612 3648318..3648716 1 NC_011601.1 cytochrome d ubiquinol oxidase subunit III 3648716 yhcB 7064612 yhcB Escherichia coli O127:H6 str. E2348/69 cytochrome d ubiquinol oxidase subunit III YP_002330972.1 3648318 D 574521 CDS YP_002330973.1 215488542 7064609 3648870..3650237 1 NC_011601.1 serine endoprotease 3650237 degQ 7064609 degQ Escherichia coli O127:H6 str. E2348/69 serine endoprotease YP_002330973.1 3648870 D 574521 CDS YP_002330974.1 215488543 7065005 3650327..3651394 1 NC_011601.1 serine endoprotease 3651394 degS 7065005 degS Escherichia coli O127:H6 str. E2348/69 serine endoprotease YP_002330974.1 3650327 D 574521 CDS YP_002330975.1 215488544 7065006 complement(3651457..3652395) 1 NC_011601.1 oxidizes malate to oxaloacetate; malate dehydrogenase 3652395 mdh 7065006 mdh Escherichia coli O127:H6 str. E2348/69 malate dehydrogenase YP_002330975.1 3651457 R 574521 CDS YP_002330976.1 215488545 7065298 3652830..3653300 1 NC_011601.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 3653300 argR 7065298 argR Escherichia coli O127:H6 str. E2348/69 arginine repressor ArgR YP_002330976.1 3652830 D 574521 CDS YP_002330977.1 215488546 7061376 3653664..3653927 1 NC_011601.1 hypothetical protein 3653927 yhcN 7061376 yhcN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330977.1 3653664 D 574521 CDS YP_002330978.1 215488547 7064613 complement(3653982..3654254) 1 NC_011601.1 barnase inhibitor 3654254 yhcO 7064613 yhcO Escherichia coli O127:H6 str. E2348/69 barnase inhibitor YP_002330978.1 3653982 R 574521 CDS YP_002330979.1 215488548 7064614 complement(3654346..3656313) 1 NC_011601.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB 3656313 aaeB 7064614 aaeB Escherichia coli O127:H6 str. E2348/69 p-hydroxybenzoic acid efflux subunit AaeB YP_002330979.1 3654346 R 574521 CDS YP_002330980.1 215488549 7061175 complement(3656319..3657251) 1 NC_011601.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA 3657251 aaeA 7061175 aaeA Escherichia coli O127:H6 str. E2348/69 p-hydroxybenzoic acid efflux subunit AaeA YP_002330980.1 3656319 R 574521 CDS YP_002330981.1 215488550 7061174 complement(3657259..3657462) 1 NC_011601.1 membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein 3657462 aaeX 7061174 aaeX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330981.1 3657259 R 574521 CDS YP_002330982.1 215488551 7061176 3657645..3658574 1 NC_011601.1 DNA-binding transcriptional regulator 3658574 aaeR 7061176 aaeR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002330982.1 3657645 D 574521 CDS YP_002330983.1 215488552 7061127 3658803..3660176 1 NC_011601.1 transposase of ISEc13 3660176 7061127 E2348C_3515 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002330983.1 3658803 D 574521 CDS YP_002330984.1 215488553 7062641 complement(3660260..3661705) 1 NC_011601.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD 3661705 tldD 7062641 tldD Escherichia coli O127:H6 str. E2348/69 protease TldD YP_002330984.1 3660260 R 574521 CDS YP_002330985.1 215488554 7061808 complement(3661861..3665661) 1 NC_011601.1 hypothetical protein 3665661 yhdP 7061808 yhdP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330985.1 3661861 R 574521 CDS YP_002330986.1 215488555 7064620 complement(3665729..3667198) 1 NC_011601.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 3667198 rng 7064620 rng Escherichia coli O127:H6 str. E2348/69 ribonuclease G YP_002330986.1 3665729 R 574521 CDS YP_002330987.1 215488556 7060852 complement(3667188..3667781) 1 NC_011601.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3667781 yhdE 7060852 yhdE Escherichia coli O127:H6 str. E2348/69 Maf-like protein YP_002330987.1 3667188 R 574521 CDS YP_002330988.1 215488557 7064615 complement(3667790..3668278) 1 NC_011601.1 part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD 3668278 mreD 7064615 mreD Escherichia coli O127:H6 str. E2348/69 rod shape-determining protein MreD YP_002330988.1 3667790 R 574521 CDS YP_002330989.1 215488558 7060869 complement(3668278..3669381) 1 NC_011601.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 3669381 mreC 7060869 mreC Escherichia coli O127:H6 str. E2348/69 rod shape-determining protein MreC YP_002330989.1 3668278 R 574521 CDS YP_002330990.1 215488559 7060868 complement(3669447..3670490) 1 NC_011601.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 3670490 mreB 7060868 mreB Escherichia coli O127:H6 str. E2348/69 rod shape-determining protein MreB YP_002330990.1 3669447 R 574521 CDS YP_002330991.1 215488560 7060867 complement(3670795..3672735) 1 NC_011601.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD 3672735 csrD 7060867 csrD Escherichia coli O127:H6 str. E2348/69 regulatory protein CsrD YP_002330991.1 3670795 R 574521 CDS YP_002330992.1 215488561 7065165 3672887..3673861 1 NC_011601.1 oxidoreductase, Zn-dependent and NAD(P)-binding 3673861 yhdH 7065165 yhdH Escherichia coli O127:H6 str. E2348/69 oxidoreductase, Zn-dependent and NAD(P)-binding YP_002330992.1 3672887 D 574521 CDS YP_002330993.1 215488562 7064616 3674839..3675309 1 NC_011601.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3675309 accB 7064616 accB Escherichia coli O127:H6 str. E2348/69 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_002330993.1 3674839 D 574521 CDS YP_002330994.1 215488563 7062381 3675320..3676669 1 NC_011601.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3676669 accC 7062381 accC Escherichia coli O127:H6 str. E2348/69 acetyl-CoA carboxylase biotin carboxylase subunit YP_002330994.1 3675320 D 574521 CDS YP_002330995.1 215488564 7062382 3676778..3677020 1 NC_011601.1 hypothetical protein 3677020 yhdT 7062382 yhdT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002330995.1 3676778 D 574521 CDS YP_002330996.1 215488565 7064621 3677010..3678461 1 NC_011601.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3678461 panF 7064621 panF Escherichia coli O127:H6 str. E2348/69 sodium/panthothenate symporter YP_002330996.1 3677010 D 574521 CDS YP_002330997.1 215488566 7062910 3678473..3679354 1 NC_011601.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 3679354 prmA 7062910 prmA Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L11 methyltransferase YP_002330997.1 3678473 D 574521 CDS YP_002330998.1 215488567 7061293 3679683..3680648 1 NC_011601.1 tRNA-dihydrouridine synthase B 3680648 dusB 7061293 dusB Escherichia coli O127:H6 str. E2348/69 tRNA-dihydrouridine synthase B YP_002330998.1 3679683 D 574521 CDS YP_002330999.1 215488568 7065072 3680674..3680970 1 NC_011601.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3680970 fis 7065072 fis Escherichia coli O127:H6 str. E2348/69 DNA-binding protein Fis YP_002330999.1 3680674 D 574521 CDS YP_002331000.1 215488569 7062128 3681056..3681940 1 NC_011601.1 methyltransferase 3681940 yhdJ 7062128 yhdJ Escherichia coli O127:H6 str. E2348/69 methyltransferase YP_002331000.1 3681056 D 574521 CDS YP_002331001.1 215488570 7064617 3682024..3682203 1 NC_011601.1 membrane protein 3682203 yhdU 7064617 yhdU Escherichia coli O127:H6 str. E2348/69 membrane protein YP_002331001.1 3682024 D 574521 CDS YP_002331002.1 215488571 7064622 complement(3682206..3682868) 1 NC_011601.1 DNA-binding transcriptional regulator EnvR 3682868 envR 7064622 envR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator EnvR YP_002331002.1 3682206 R 574521 CDS YP_002331003.1 215488572 7063860 3683267..3684424 1 NC_011601.1 hypothetical protein 3684424 acrE 7063860 acrE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331003.1 3683267 D 574521 CDS YP_002331004.1 215488573 7062399 3684436..3687540 1 NC_011601.1 multidrug efflux system protein 3687540 acrF 7062399 acrF Escherichia coli O127:H6 str. E2348/69 multidrug efflux system protein YP_002331004.1 3684436 D 574521 CDS YP_002331005.1 215488574 7062400 3687793..3688014 1 NC_011601.1 outer membrane protein 3688014 yhdV 7062400 yhdV Escherichia coli O127:H6 str. E2348/69 outer membrane protein YP_002331005.1 3687793 D 574521 CDS YP_002331006.1 215488575 7064623 3688445..3689470 1 NC_011601.1 periplasmic binding transport protein; periplasmic-binding component of ABC superfamily 3689470 yhdW 7064623 yhdW Escherichia coli O127:H6 str. E2348/69 periplasmic binding transport protein; periplasmic-binding component of ABC superfamily YP_002331006.1 3688445 D 574521 CDS YP_002331007.1 215488576 7064624 3689538..3690719 1 NC_011601.1 amino-acid transporter subunit 3690719 yhdX 7064624 yhdX Escherichia coli O127:H6 str. E2348/69 amino-acid transporter subunit YP_002331007.1 3689538 D 574521 CDS YP_002331008.1 215488577 7064625 3690729..3691832 1 NC_011601.1 amino-acid transporter subunit 3691832 yhdY 7064625 yhdY Escherichia coli O127:H6 str. E2348/69 amino-acid transporter subunit YP_002331008.1 3690729 D 574521 CDS YP_002331009.1 215488578 7064626 3691840..3692598 1 NC_011601.1 amino-acid transporter subunit 3692598 yhdZ 7064626 yhdZ Escherichia coli O127:H6 str. E2348/69 amino-acid transporter subunit YP_002331009.1 3691840 D 574521 CDS YP_002331010.1 215488579 7064545 3698389..3698943 1 NC_011601.1 hypothetical protein 3698943 yrdA 7064545 yrdA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331010.1 3698389 D 574521 CDS YP_002331011.1 215488580 7063230 complement(3698919..3699176) 1 NC_011601.1 hypothetical protein 3699176 yrdB 7063230 yrdB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331011.1 3698919 R 574521 CDS YP_002331012.1 215488581 7063231 complement(3699173..3699991) 1 NC_011601.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 3699991 aroE 7063231 aroE Escherichia coli O127:H6 str. E2348/69 shikimate 5-dehydrogenase YP_002331012.1 3699173 R 574521 CDS YP_002331013.1 215488582 7061393 complement(3699996..3700568) 1 NC_011601.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor 3700568 rimN 7061393 rimN Escherichia coli O127:H6 str. E2348/69 ribosome maturation factor YP_002331013.1 3699996 R 574521 CDS YP_002331014.1 215488583 7060832 complement(3700573..3701115) 1 NC_011601.1 DNA topoisomerase 3701115 yrdD 7060832 yrdD Escherichia coli O127:H6 str. E2348/69 DNA topoisomerase YP_002331014.1 3700573 R 574521 CDS YP_002331015.1 215488584 7063232 complement(3701144..3701617) 1 NC_011601.1 hypothetical protein 3701617 smg 7063232 smg Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331015.1 3701144 R 574521 CDS YP_002331016.1 215488585 7062728 complement(3701589..3702713) 1 NC_011601.1 DNA protecting protein DprA 3702713 smf 7062728 smf Escherichia coli O127:H6 str. E2348/69 DNA protecting protein DprA YP_002331016.1 3701589 R 574521 CDS YP_002331017.1 215488586 7062727 3702843..3703352 1 NC_011601.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3703352 def 7062727 def Escherichia coli O127:H6 str. E2348/69 peptide deformylase YP_002331017.1 3702843 D 574521 CDS YP_002331018.1 215488587 7065242 3703367..3704314 1 NC_011601.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3704314 fmt 7065242 fmt Escherichia coli O127:H6 str. E2348/69 methionyl-tRNA formyltransferase YP_002331018.1 3703367 D 574521 CDS YP_002331019.1 215488588 7061935 3704360..3705649 1 NC_011601.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase GidB 3705649 rsmB 7061935 rsmB Escherichia coli O127:H6 str. E2348/69 16S rRNA methyltransferase GidB YP_002331019.1 3704360 D 574521 CDS YP_002331020.1 215488589 7064555 3705671..3707047 1 NC_011601.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 3707047 trkA 7064555 trkA Escherichia coli O127:H6 str. E2348/69 potassium transporter peripheral membrane protein YP_002331020.1 3705671 D 574521 CDS YP_002331021.1 215488590 7062239 3707177..3707587 1 NC_011601.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3707587 mscL 7062239 mscL Escherichia coli O127:H6 str. E2348/69 large-conductance mechanosensitive channel YP_002331021.1 3707177 D 574521 CDS YP_002331022.1 215488591 7060872 complement(3707584..3707802) 1 NC_011601.1 hypothetical protein 3707802 yhdL 7060872 yhdL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331022.1 3707584 R 574521 CDS YP_002331023.1 215488592 7064618 complement(3707858..3708283) 1 NC_011601.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator 3708283 zntR 7064618 zntR Escherichia coli O127:H6 str. E2348/69 zinc-responsive transcriptional regulator YP_002331023.1 3707858 R 574521 CDS YP_002331024.1 215488593 7063261 complement(3708294..3708662) 1 NC_011601.1 hypothetical protein 3708662 yhdN 7063261 yhdN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331024.1 3708294 R 574521 CDS YP_002331025.1 215488594 7064619 complement(3708769..3709152) 1 NC_011601.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 3709152 rplQ 7064619 rplQ Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L17 YP_002331025.1 3708769 R 574521 CDS YP_002331026.1 215488595 7061844 complement(3709193..3710182) 1 NC_011601.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 3710182 rpoA 7061844 rpoA Escherichia coli O127:H6 str. E2348/69 DNA-directed RNA polymerase subunit alpha YP_002331026.1 3709193 R 574521 CDS YP_002331027.1 215488596 7061863 complement(3710208..3710828) 1 NC_011601.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 3710828 rpsD 7061863 rpsD Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S4 YP_002331027.1 3710208 R 574521 CDS YP_002331028.1 215488597 7061876 complement(3710862..3711251) 1 NC_011601.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 3711251 rpsK 7061876 rpsK Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S11 YP_002331028.1 3710862 R 574521 CDS YP_002331029.1 215488598 7061883 complement(3711268..3711624) 1 NC_011601.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 3711624 rpsM 7061883 rpsM Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S13 YP_002331029.1 3711268 R 574521 CDS YP_002331030.1 215488599 7061155 complement(3711771..3711887) 1 NC_011601.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 3711887 rpmJ 7061155 rpmJ Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L36 YP_002331030.1 3711771 R 574521 CDS YP_002331031.1 215488600 7061862 complement(3711919..3713250) 1 NC_011601.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 3713250 secY 7061862 secY Escherichia coli O127:H6 str. E2348/69 preprotein translocase subunit SecY YP_002331031.1 3711919 R 574521 CDS YP_002331032.1 215488601 7065359 complement(3713258..3713692) 1 NC_011601.1 late assembly protein; 50S ribosomal protein L15 3713692 rplO 7065359 rplO Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L15 YP_002331032.1 3713258 R 574521 CDS YP_002331033.1 215488602 7061842 complement(3713696..3713875) 1 NC_011601.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 3713875 rpmD 7061842 rpmD Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L30 YP_002331033.1 3713696 R 574521 CDS YP_002331034.1 215488603 7061856 complement(3713879..3714382) 1 NC_011601.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 3714382 rpsE 7061856 rpsE Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S5 YP_002331034.1 3713879 R 574521 CDS YP_002331035.1 215488604 7061877 complement(3714397..3714750) 1 NC_011601.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 3714750 rplR 7061877 rplR Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L18 YP_002331035.1 3714397 R 574521 CDS YP_002331036.1 215488605 7061845 complement(3714760..3715293) 1 NC_011601.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 3715293 rplF 7061845 rplF Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L6 YP_002331036.1 3714760 R 574521 CDS YP_002331037.1 215488606 7061835 complement(3715306..3715698) 1 NC_011601.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 3715698 rpsH 7061835 rpsH Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S8 YP_002331037.1 3715306 R 574521 CDS YP_002331038.1 215488607 7061880 complement(3715732..3716037) 1 NC_011601.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 3716037 rpsN 7061880 rpsN Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S14 YP_002331038.1 3715732 R 574521 CDS YP_002331039.1 215488608 7061886 complement(3716052..3716591) 1 NC_011601.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 3716591 rplE 7061886 rplE Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L5 YP_002331039.1 3716052 R 574521 CDS YP_002331040.1 215488609 7061834 complement(3716606..3716920) 1 NC_011601.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 3716920 rplX 7061834 rplX Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L24 YP_002331040.1 3716606 R 574521 CDS YP_002331041.1 215488610 7061851 complement(3716931..3717302) 1 NC_011601.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 3717302 rplN 7061851 rplN Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L14 YP_002331041.1 3716931 R 574521 CDS YP_002331042.1 215488611 7061841 complement(3717467..3717721) 1 NC_011601.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 3717721 rpsQ 7061841 rpsQ Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S17 YP_002331042.1 3717467 R 574521 CDS YP_002331043.1 215488612 7061889 complement(3717721..3717912) 1 NC_011601.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 3717912 rpmC 7061889 rpmC Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L29 YP_002331043.1 3717721 R 574521 CDS YP_002331044.1 215488613 7061855 complement(3717912..3718322) 1 NC_011601.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 3718322 rplP 7061855 rplP Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L16 YP_002331044.1 3717912 R 574521 CDS YP_002331045.1 215488614 7061843 complement(3718335..3719036) 1 NC_011601.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 3719036 rpsC 7061843 rpsC Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S3 YP_002331045.1 3718335 R 574521 CDS YP_002331046.1 215488615 7061875 complement(3719054..3719386) 1 NC_011601.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 3719386 rplV 7061875 rplV Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L22 YP_002331046.1 3719054 R 574521 CDS YP_002331047.1 215488616 7061849 complement(3719401..3719679) 1 NC_011601.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 3719679 rpsS 7061849 rpsS Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S19 YP_002331047.1 3719401 R 574521 CDS YP_002331048.1 215488617 7061891 complement(3719696..3720517) 1 NC_011601.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 3720517 rplB 7061891 rplB Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L2 YP_002331048.1 3719696 R 574521 CDS YP_002331049.1 215488618 7061831 complement(3720535..3720837) 1 NC_011601.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 3720837 rplW 7061831 rplW Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L23 YP_002331049.1 3720535 R 574521 CDS YP_002331050.1 215488619 7061850 complement(3720834..3721439) 1 NC_011601.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 3721439 rplD 7061850 rplD Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L4 YP_002331050.1 3720834 R 574521 CDS YP_002331051.1 215488620 7061833 complement(3721450..3722079) 1 NC_011601.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 3722079 rplC 7061833 rplC Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L3 YP_002331051.1 3721450 R 574521 CDS YP_002331052.1 215488621 7061832 complement(3722112..3722423) 1 NC_011601.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 3722423 rpsJ 7061832 rpsJ Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S10 YP_002331052.1 3722112 R 574521 CDS YP_002331053.1 215488622 7061882 3722802..3723269 1 NC_011601.1 leader peptidase HopD 3723269 7061882 E2348C_3585 Escherichia coli O127:H6 str. E2348/69 leader peptidase HopD YP_002331053.1 3722802 D 574521 CDS YP_002331054.1 215488623 7062642 complement(3723266..3723742) 1 NC_011601.1 iron storage protein; bacterioferritin 3723742 bfr 7062642 bfr Escherichia coli O127:H6 str. E2348/69 bacterioferritin YP_002331054.1 3723266 R 574521 CDS YP_002331055.1 215488624 7062511 complement(3723815..3724009) 1 NC_011601.1 bacterioferritin-associated ferredoxin 3724009 bfd 7062511 bfd Escherichia coli O127:H6 str. E2348/69 bacterioferritin-associated ferredoxin YP_002331055.1 3723815 R 574521 CDS YP_002331056.1 215488625 7062510 complement(3724192..3725376) 1 NC_011601.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 3725376 tufA 7062510 tufA Escherichia coli O127:H6 str. E2348/69 elongation factor Tu YP_002331056.1 3724192 R 574521 CDS YP_002331057.1 215488626 7062279 complement(3725447..3727561) 1 NC_011601.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 3727561 fusA 7062279 fusA Escherichia coli O127:H6 str. E2348/69 elongation factor G YP_002331057.1 3725447 R 574521 CDS YP_002331058.1 215488627 7061604 complement(3727658..3728128) 1 NC_011601.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 3728128 rpsG 7061604 rpsG Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S7 YP_002331058.1 3727658 R 574521 CDS YP_002331059.1 215488628 7061879 complement(3728225..3728599) 1 NC_011601.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 3728599 rpsL 7061879 rpsL Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S12 YP_002331059.1 3728225 R 574521 CDS YP_002331060.1 215488629 7061884 complement(3728725..3729012) 1 NC_011601.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 3729012 yheL 7061884 yheL Escherichia coli O127:H6 str. E2348/69 sulfur transfer complex subunit TusB YP_002331060.1 3728725 R 574521 CDS YP_002331061.1 215488630 7064628 complement(3729020..3729379) 1 NC_011601.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 3729379 yheM 7064628 yheM Escherichia coli O127:H6 str. E2348/69 sulfur relay protein TusC YP_002331061.1 3729020 R 574521 CDS YP_002331062.1 215488631 7064629 complement(3729379..3729765) 1 NC_011601.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 3729765 yheN 7064629 yheN Escherichia coli O127:H6 str. E2348/69 sulfur transfer complex subunit TusD YP_002331062.1 3729379 R 574521 CDS YP_002331063.1 215488632 7064630 complement(3729765..3730487) 1 NC_011601.1 DNA-binding transcriptional regulator 3730487 yheO 7064630 yheO Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002331063.1 3729765 R 574521 CDS YP_002331064.1 215488633 7064631 complement(3730654..3731466) 1 NC_011601.1 rotamase; FKBP-type peptidylprolyl isomerase 3731466 fkpA 7064631 fkpA Escherichia coli O127:H6 str. E2348/69 FKBP-type peptidylprolyl isomerase YP_002331064.1 3730654 R 574521 CDS YP_002331065.1 215488634 7062134 3731687..3731905 1 NC_011601.1 hypothetical protein 3731905 slyX 7062134 slyX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331065.1 3731687 D 574521 CDS YP_002331066.1 215488635 7062726 complement(3731954..3732538) 1 NC_011601.1 rotamase; FKBP-type peptidylprolyl isomerase 3732538 slyD 7062726 slyD Escherichia coli O127:H6 str. E2348/69 FKBP-type peptidylprolyl isomerase YP_002331066.1 3731954 R 574521 CDS YP_002331067.1 215488636 7062725 complement(3732633..3732833) 1 NC_011601.1 hypothetical protein 3732833 yheV 7062725 yheV Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331067.1 3732633 R 574521 CDS YP_002331068.1 215488637 7064635 complement(3732843..3734648) 1 NC_011601.1 involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB 3734648 kefB 7064635 kefB Escherichia coli O127:H6 str. E2348/69 glutathione-regulated potassium-efflux system protein KefB YP_002331068.1 3732843 R 574521 CDS YP_002331069.1 215488638 7061500 complement(3734648..3735202) 1 NC_011601.1 required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 3735202 kefG 7061500 kefG Escherichia coli O127:H6 str. E2348/69 glutathione-regulated potassium-efflux system ancillary protein KefG YP_002331069.1 3734648 R 574521 CDS YP_002331070.1 215488639 7061503 3735330..3737243 1 NC_011601.1 ABC transporter ATP-binding protein 3737243 yheS 7061503 yheS Escherichia coli O127:H6 str. E2348/69 ABC transporter ATP-binding protein YP_002331070.1 3735330 D 574521 CDS YP_002331071.1 215488640 7064632 3737243..3738265 1 NC_011601.1 hydrolase 3738265 yheT 7064632 yheT Escherichia coli O127:H6 str. E2348/69 hydrolase YP_002331071.1 3737243 D 574521 CDS YP_002331072.1 215488641 7064633 3738259..3738477 1 NC_011601.1 hypothetical protein 3738477 yheU 7064633 yheU Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331072.1 3738259 D 574521 CDS YP_002331073.1 215488642 7064634 3738531..3739400 1 NC_011601.1 phosphoribulokinase 3739400 prkB 7064634 prkB Escherichia coli O127:H6 str. E2348/69 phosphoribulokinase YP_002331073.1 3738531 D 574521 CDS YP_002331074.1 215488643 7061291 complement(3739455..3739859) 1 NC_011601.1 hypothetical protein 3739859 yhfA 7061291 yhfA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331074.1 3739455 R 574521 CDS YP_002331075.1 215488644 7064636 3740161..3740793 1 NC_011601.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3740793 crp 7064636 crp Escherichia coli O127:H6 str. E2348/69 cAMP-regulatory protein YP_002331075.1 3740161 D 574521 CDS YP_002331076.1 215488645 7062847 3740844..3742934 1 NC_011601.1 hypothetical protein 3742934 yhfK 7062847 yhfK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331076.1 3740844 D 574521 CDS YP_002331077.1 215488646 7064638 complement(3743001..3744221) 1 NC_011601.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase 3744221 argD 7064638 argD Escherichia coli O127:H6 str. E2348/69 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase YP_002331077.1 3743001 R 574521 CDS YP_002331078.1 215488647 7061368 complement(3744307..3744870) 1 NC_011601.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 3744870 pabA 7061368 pabA Escherichia coli O127:H6 str. E2348/69 para-aminobenzoate synthase component II YP_002331078.1 3744307 R 574521 CDS YP_002331079.1 215488648 7062900 complement(3744902..3745504) 1 NC_011601.1 cell filamentation protein Fic 3745504 fic 7062900 fic Escherichia coli O127:H6 str. E2348/69 cell filamentation protein Fic YP_002331079.1 3744902 R 574521 CDS YP_002331080.1 215488649 7062117 complement(3745494..3745661) 1 NC_011601.1 hypothetical protein 3745661 yhfG 7062117 yhfG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331080.1 3745494 R 574521 CDS YP_002331081.1 215488650 7064637 complement(3745766..3746338) 1 NC_011601.1 peptidyl-prolyl cis-trans isomerase A 3746338 ppiA 7064637 ppiA Escherichia coli O127:H6 str. E2348/69 peptidyl-prolyl cis-trans isomerase A YP_002331081.1 3745766 R 574521 CDS YP_002331082.1 215488651 7061270 3746609..3747790 1 NC_011601.1 hypothetical protein 3747790 tsgA 7061270 tsgA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331082.1 3746609 D 574521 CDS YP_002331083.1 215488652 7062271 3748052..3750595 1 NC_011601.1 nitrite reductase, large subunit, NAD(P)H-binding 3750595 nirB 7062271 nirB Escherichia coli O127:H6 str. E2348/69 nitrite reductase, large subunit, NAD(P)H-binding YP_002331083.1 3748052 D 574521 CDS YP_002331084.1 215488653 7065397 3750592..3750918 1 NC_011601.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3750918 nirD 7065397 nirD Escherichia coli O127:H6 str. E2348/69 nitrite reductase small subunit YP_002331084.1 3750592 D 574521 CDS YP_002331085.1 215488654 7065399 3751044..3751850 1 NC_011601.1 member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3751850 nirC 7065399 nirC Escherichia coli O127:H6 str. E2348/69 nitrite transporter NirC YP_002331085.1 3751044 D 574521 CDS YP_002331086.1 215488655 7065398 3751869..3753242 1 NC_011601.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3753242 cysG 7065398 cysG Escherichia coli O127:H6 str. E2348/69 siroheme synthase YP_002331086.1 3751869 D 574521 CDS YP_002331087.1 215488656 7065198 3753494..3753661 1 NC_011601.1 hypothetical protein 3753661 yhfL 7065198 yhfL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331087.1 3753494 D 574521 CDS YP_002331088.1 215488657 7064639 complement(3753768..3754853) 1 NC_011601.1 hypothetical protein 3754853 yhfS 7064639 yhfS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331088.1 3753768 R 574521 CDS YP_002331089.1 215488658 7064640 complement(3754865..3756169) 1 NC_011601.1 hypothetical protein 3756169 yhfT 7064640 yhfT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331089.1 3754865 R 574521 CDS YP_002331090.1 215488659 7064641 complement(3756181..3756534) 1 NC_011601.1 hypothetical protein 3756534 yhfU 7064641 yhfU Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331090.1 3756181 R 574521 CDS YP_002331091.1 215488660 7064642 complement(3756545..3757423) 1 NC_011601.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); hydrolase 3757423 php 7064642 php Escherichia coli O127:H6 str. E2348/69 hydrolase YP_002331091.1 3756545 R 574521 CDS YP_002331092.1 215488661 7060750 complement(3757420..3758646) 1 NC_011601.1 mutase 3758646 yhfW 7060750 yhfW Escherichia coli O127:H6 str. E2348/69 mutase YP_002331092.1 3757420 R 574521 CDS YP_002331093.1 215488662 7064643 complement(3758647..3759810) 1 NC_011601.1 amino acid racemase 3759810 yhfX 7064643 yhfX Escherichia coli O127:H6 str. E2348/69 amino acid racemase YP_002331093.1 3758647 R 574521 CDS YP_002331094.1 215488663 7064644 complement(3759894..3760256) 1 NC_011601.1 hypothetical protein 3760256 yhfY 7064644 yhfY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331094.1 3759894 R 574521 CDS YP_002331095.1 215488664 7064645 complement(3760273..3761178) 1 NC_011601.1 hypothetical protein 3761178 yhfZ 7064645 yhfZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331095.1 3760273 R 574521 CDS YP_002331096.1 215488665 7064646 complement(3761338..3762342) 1 NC_011601.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 3762342 trpS 7064646 trpS Escherichia coli O127:H6 str. E2348/69 tryptophanyl-tRNA synthetase YP_002331096.1 3761338 R 574521 CDS YP_002331097.1 215488666 7062261 complement(3762335..3763093) 1 NC_011601.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 3763093 gph 7062261 gph Escherichia coli O127:H6 str. E2348/69 phosphoglycolate phosphatase YP_002331097.1 3762335 R 574521 CDS YP_002331098.1 215488667 7064233 complement(3763086..3763763) 1 NC_011601.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 3763763 rpe 7064233 rpe Escherichia coli O127:H6 str. E2348/69 ribulose-phosphate 3-epimerase YP_002331098.1 3763086 R 574521 CDS YP_002331099.1 215488668 7061825 complement(3763781..3764617) 1 NC_011601.1 DNA adenine methylase 3764617 dam 7061825 dam Escherichia coli O127:H6 str. E2348/69 DNA adenine methylase YP_002331099.1 3763781 R 574521 CDS YP_002331100.1 215488669 7065218 complement(3764724..3766010) 1 NC_011601.1 hypothetical protein 3766010 damX 7065218 damX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331100.1 3764724 R 574521 CDS YP_002331101.1 215488670 7065219 complement(3766102..3767190) 1 NC_011601.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 3767190 aroB 7065219 aroB Escherichia coli O127:H6 str. E2348/69 3-dehydroquinate synthase YP_002331101.1 3766102 R 574521 CDS YP_002331102.1 215488671 7061390 complement(3767247..3767768) 1 NC_011601.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 3767768 aroK 7061390 aroK Escherichia coli O127:H6 str. E2348/69 shikimate kinase I YP_002331102.1 3767247 R 574521 CDS YP_002331103.1 215488672 7061397 complement(3768169..3769407) 1 NC_011601.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ 3769407 hofQ 7061397 hofQ Escherichia coli O127:H6 str. E2348/69 outer membrane porin HofQ YP_002331103.1 3768169 R 574521 CDS YP_002331104.1 215488673 7062166 complement(3769712..3770152) 1 NC_011601.1 membrane protein 3770152 hofO 7062166 hofO Escherichia coli O127:H6 str. E2348/69 membrane protein YP_002331104.1 3769712 R 574521 CDS YP_002331105.1 215488674 7062165 complement(3770136..3770675) 1 NC_011601.1 fimbrial assembly protein 3770675 hofN 7062165 hofN Escherichia coli O127:H6 str. E2348/69 fimbrial assembly protein YP_002331105.1 3770136 R 574521 CDS YP_002331106.1 215488675 7062164 complement(3770675..3771454) 1 NC_011601.1 pilus assembly protein 3771454 hofM 7062164 hofM Escherichia coli O127:H6 str. E2348/69 pilus assembly protein YP_002331106.1 3770675 R 574521 CDS YP_002331107.1 215488676 7062163 3771574..3774126 1 NC_011601.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3774126 mrcA 7062163 mrcA Escherichia coli O127:H6 str. E2348/69 peptidoglycan synthetase YP_002331107.1 3771574 D 574521 CDS YP_002331108.1 215488677 7060863 complement(3774292..3774852) 1 NC_011601.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 3774852 nudE 7060863 nudE Escherichia coli O127:H6 str. E2348/69 ADP-ribose diphosphatase NudE YP_002331108.1 3774292 R 574521 CDS YP_002331109.1 215488678 7065429 3775172..3777307 1 NC_011601.1 hypothetical protein 3777307 yrfF 7065429 yrfF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331109.1 3775172 D 574521 CDS YP_002331110.1 215488679 7063233 3777372..3778040 1 NC_011601.1 hydrolase 3778040 yrfG 7063233 yrfG Escherichia coli O127:H6 str. E2348/69 hydrolase YP_002331110.1 3777372 D 574521 CDS YP_002331111.1 215488680 7063234 3778051..3778452 1 NC_011601.1 ribosome-associated heat shock protein Hsp15 3778452 hslR 7063234 hslR Escherichia coli O127:H6 str. E2348/69 ribosome-associated heat shock protein Hsp15 YP_002331111.1 3778051 D 574521 CDS YP_002331112.1 215488681 7062184 3778477..3779355 1 NC_011601.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 3779355 hslO 7062184 hslO Escherichia coli O127:H6 str. E2348/69 Hsp33-like chaperonin YP_002331112.1 3778477 D 574521 CDS YP_002331113.1 215488682 7062183 complement(3779418..3781142) 1 NC_011601.1 hypothetical protein 3781142 yhgE 7062183 yhgE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331113.1 3779418 R 574521 CDS YP_002331114.1 215488683 7064648 3781521..3783143 1 NC_011601.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3783143 pck 7064648 pck Escherichia coli O127:H6 str. E2348/69 phosphoenolpyruvate carboxykinase YP_002331114.1 3781521 D 574521 CDS YP_002331115.1 215488684 7062915 3783628..3783924 1 NC_011601.1 hypothetical protein 3783924 7062915 E2348C_3648 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331115.1 3783628 D 574521 CDS YP_002331116.1 215488685 7062643 complement(3783956..3785308) 1 NC_011601.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 3785308 envZ 7062643 envZ Escherichia coli O127:H6 str. E2348/69 osmolarity sensor protein YP_002331116.1 3783956 R 574521 CDS YP_002331117.1 215488686 7063861 complement(3785305..3786024) 1 NC_011601.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 3786024 ompR 7063861 ompR Escherichia coli O127:H6 str. E2348/69 osmolarity response regulator YP_002331117.1 3785305 R 574521 CDS YP_002331118.1 215488687 7062878 3786252..3786728 1 NC_011601.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 3786728 greB 7062878 greB Escherichia coli O127:H6 str. E2348/69 transcription elongation factor GreB YP_002331118.1 3786252 D 574521 CDS YP_002331119.1 215488688 7064240 3786825..3789146 1 NC_011601.1 transcriptional accessory protein 3789146 yhgF 7064240 yhgF Escherichia coli O127:H6 str. E2348/69 transcriptional accessory protein YP_002331119.1 3786825 D 574521 CDS YP_002331120.1 215488689 7064649 3789584..3789811 1 NC_011601.1 ferrous iron transport protein A 3789811 feoA 7064649 feoA Escherichia coli O127:H6 str. E2348/69 ferrous iron transport protein A YP_002331120.1 3789584 D 574521 CDS YP_002331121.1 215488690 7062097 3789828..3792149 1 NC_011601.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3792149 feoB 7062097 feoB Escherichia coli O127:H6 str. E2348/69 ferrous iron transport protein B YP_002331121.1 3789828 D 574521 CDS YP_002331122.1 215488691 7062098 3792149..3792385 1 NC_011601.1 DNA-binding transcriptional regulator 3792385 feoC 7062098 feoC Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002331122.1 3792149 D 574521 CDS YP_002331123.1 215488692 7062099 3792588..3793469 1 NC_011601.1 hypothetical protein 3793469 yhgA 7062099 yhgA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331123.1 3792588 D 574521 CDS YP_002331124.1 215488693 7064647 complement(3793689..3794459) 1 NC_011601.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 3794459 bioH 7064647 bioH Escherichia coli O127:H6 str. E2348/69 carboxylesterase BioH YP_002331124.1 3793689 R 574521 CDS YP_002331125.1 215488694 7062525 3794497..3795180 1 NC_011601.1 involved in high-affinity gluconate transport; gluconate periplasmic binding protein 3795180 gntX 7062525 gntX Escherichia coli O127:H6 str. E2348/69 gluconate periplasmic binding protein YP_002331125.1 3794497 D 574521 CDS YP_002331126.1 215488695 7064230 3795239..3795814 1 NC_011601.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 3795814 gntY 7064230 gntY Escherichia coli O127:H6 str. E2348/69 DNA uptake protein YP_002331126.1 3795239 D 574521 CDS YP_002331127.1 215488696 7064231 3796178..3797494 1 NC_011601.1 gluconate transporter, high-affinity GNT Isystem 3797494 gntT 7064231 gntT Escherichia coli O127:H6 str. E2348/69 gluconate transporter, high-affinity GNT Isystem YP_002331127.1 3796178 D 574521 CDS YP_002331128.1 215488697 7061738 complement(3797605..3799689) 1 NC_011601.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 3799689 malQ 7061738 malQ Escherichia coli O127:H6 str. E2348/69 4-alpha-glucanotransferase YP_002331128.1 3797605 R 574521 CDS YP_002331129.1 215488698 7065277 complement(3799699..3802092) 1 NC_011601.1 maltodextrin phosphorylase 3802092 malP 7065277 malP Escherichia coli O127:H6 str. E2348/69 maltodextrin phosphorylase YP_002331129.1 3799699 R 574521 CDS YP_002331130.1 215488699 7065276 3802714..3805419 1 NC_011601.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3805419 malT 7065276 malT Escherichia coli O127:H6 str. E2348/69 transcriptional regulator MalT YP_002331130.1 3802714 D 574521 CDS YP_002331131.1 215488700 7065279 complement(3805462..3806478) 1 NC_011601.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase 3806478 rtcA 7065279 rtcA Escherichia coli O127:H6 str. E2348/69 RNA 3'-terminal-phosphate cyclase YP_002331131.1 3805462 R 574521 CDS YP_002331132.1 215488701 7064573 complement(3806482..3807708) 1 NC_011601.1 hypothetical protein 3807708 rtcB 7064573 rtcB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331132.1 3806482 R 574521 CDS YP_002331133.1 215488702 7064574 3807897..3809495 1 NC_011601.1 sigma 54-dependent transcriptional regulator of rtcBA expression 3809495 rtcR 7064574 rtcR Escherichia coli O127:H6 str. E2348/69 sigma 54-dependent transcriptional regulator of rtcBA expression YP_002331133.1 3807897 D 574521 CDS YP_002331134.1 215488703 7064575 complement(3809477..3810235) 1 NC_011601.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR 3810235 glpR 7064575 glpR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor GlpR YP_002331134.1 3809477 R 574521 CDS YP_002331135.1 215488704 7061701 complement(3810252..3811082) 1 NC_011601.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 3811082 glpG 7061701 glpG Escherichia coli O127:H6 str. E2348/69 intramembrane serine protease GlpG YP_002331135.1 3810252 R 574521 CDS YP_002331136.1 215488705 7061698 complement(3811127..3811453) 1 NC_011601.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 3811453 glpE 7061698 glpE Escherichia coli O127:H6 str. E2348/69 thiosulfate sulfurtransferase YP_002331136.1 3811127 R 574521 CDS YP_002331137.1 215488706 7061696 3811643..3813148 1 NC_011601.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3813148 glpD 7061696 glpD Escherichia coli O127:H6 str. E2348/69 glycerol-3-phosphate dehydrogenase YP_002331137.1 3811643 D 574521 CDS YP_002331138.1 215488707 7061695 complement(3813202..3813807) 1 NC_011601.1 hypothetical protein 3813807 7061695 E2348C_3671 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331138.1 3813202 R 574521 CDS YP_002331139.1 215488708 7062644 complement(3813810..3814577) 1 NC_011601.1 hypothetical protein 3814577 7062644 E2348C_3672 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331139.1 3813810 R 574521 CDS YP_002331140.1 215488709 7062646 complement(3816314..3818761) 1 NC_011601.1 glycogen phosphorylase 3818761 glgP 7062646 glgP Escherichia coli O127:H6 str. E2348/69 glycogen phosphorylase YP_002331140.1 3816314 R 574521 CDS YP_002331141.1 215488710 7061669 complement(3818780..3820213) 1 NC_011601.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 3820213 glgA 7061669 glgA Escherichia coli O127:H6 str. E2348/69 glycogen synthase YP_002331141.1 3818780 R 574521 CDS YP_002331142.1 215488711 7061666 complement(3820213..3821508) 1 NC_011601.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 3821508 glgC 7061666 glgC Escherichia coli O127:H6 str. E2348/69 glucose-1-phosphate adenylyltransferase YP_002331142.1 3820213 R 574521 CDS YP_002331143.1 215488712 7061668 complement(3821526..3823499) 1 NC_011601.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching protein 3823499 glgX 7061668 glgX Escherichia coli O127:H6 str. E2348/69 glycogen debranching protein YP_002331143.1 3821526 R 574521 CDS YP_002331144.1 215488713 7061671 complement(3823496..3825682) 1 NC_011601.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 3825682 glgB 7061671 glgB Escherichia coli O127:H6 str. E2348/69 glycogen branching protein YP_002331144.1 3823496 R 574521 CDS YP_002331145.1 215488714 7061667 complement(3825955..3827058) 1 NC_011601.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 3827058 asd 7061667 asd Escherichia coli O127:H6 str. E2348/69 aspartate-semialdehyde dehydrogenase YP_002331145.1 3825955 R 574521 CDS YP_002331146.1 215488715 7061407 3827250..3827843 1 NC_011601.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); dITP- and XTP- hydrolase 3827843 yhgN 7061407 yhgN Escherichia coli O127:H6 str. E2348/69 dITP- and XTP- hydrolase YP_002331146.1 3827250 D 574521 CDS YP_002331147.1 215488716 7064650 complement(3827900..3829240) 1 NC_011601.1 low affinity gluconate transporter 3829240 gntU 7064650 gntU Escherichia coli O127:H6 str. E2348/69 low affinity gluconate transporter YP_002331147.1 3827900 R 574521 CDS YP_002331148.1 215488717 7062055 complement(3829244..3829771) 1 NC_011601.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 3829771 gntK 7062055 gntK Escherichia coli O127:H6 str. E2348/69 gluconate kinase YP_002331148.1 3829244 R 574521 CDS YP_002331149.1 215488718 7061736 complement(3829910..3830905) 1 NC_011601.1 DNA-binding transcriptional repressor 3830905 gntR 7061736 gntR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor YP_002331149.1 3829910 R 574521 CDS YP_002331150.1 215488719 7061737 complement(3830998..3831693) 1 NC_011601.1 hypothetical protein 3831693 yhhW 7061737 yhhW Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331150.1 3830998 R 574521 CDS YP_002331151.1 215488720 7064660 complement(3831816..3832853) 1 NC_011601.1 dehydrogenase 3832853 yhhX 7064660 yhhX Escherichia coli O127:H6 str. E2348/69 dehydrogenase YP_002331151.1 3831816 R 574521 CDS YP_002331152.1 215488721 7060817 3833187..3833675 1 NC_011601.1 YhhY; regulated by the fur regulator; unknown function; acetyltransferase YhhY 3833675 yhhY 7060817 yhhY Escherichia coli O127:H6 str. E2348/69 acetyltransferase YhhY YP_002331152.1 3833187 D 574521 CDS YP_002331153.1 215488722 7064662 complement(3833736..3835469) 1 NC_011601.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase 3835469 ggt 7064662 ggt Escherichia coli O127:H6 str. E2348/69 gamma-glutamyltranspeptidase YP_002331153.1 3833736 R 574521 CDS YP_002331154.1 215488723 7061653 3835589..3836029 1 NC_011601.1 hypothetical protein 3836029 yhhA 7061653 yhhA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331154.1 3835589 D 574521 CDS YP_002331155.1 215488724 7064651 complement(3836016..3836759) 1 NC_011601.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; glycerophosphodiester phosphodiesterase 3836759 ugpQ 7064651 ugpQ Escherichia coli O127:H6 str. E2348/69 glycerophosphodiester phosphodiesterase YP_002331155.1 3836016 R 574521 CDS YP_002331156.1 215488725 7062307 complement(3836756..3837826) 1 NC_011601.1 part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit 3837826 ugpC 7062307 ugpC Escherichia coli O127:H6 str. E2348/69 glycerol-3-phosphate transporter ATP-binding subunit YP_002331156.1 3836756 R 574521 CDS YP_002331157.1 215488726 7062305 complement(3837828..3838673) 1 NC_011601.1 with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein 3838673 ugpE 7062305 ugpE Escherichia coli O127:H6 str. E2348/69 glycerol-3-phosphate transporter membrane protein YP_002331157.1 3837828 R 574521 CDS YP_002331158.1 215488727 7062306 complement(3838670..3839557) 1 NC_011601.1 with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease 3839557 ugpA 7062306 ugpA Escherichia coli O127:H6 str. E2348/69 glycerol-3-phosphate transporter permease YP_002331158.1 3838670 R 574521 CDS YP_002331159.1 215488728 7062303 complement(3839655..3840971) 1 NC_011601.1 with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein 3840971 ugpB 7062303 ugpB Escherichia coli O127:H6 str. E2348/69 glycerol-3-phosphate transporter periplasmic binding protein YP_002331159.1 3839655 R 574521 CDS YP_002331160.1 215488729 7062304 complement(3841368..3842081) 1 NC_011601.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3842081 livF 7062304 livF Escherichia coli O127:H6 str. E2348/69 leucine/isoleucine/valine transporter ATP-binding subunit YP_002331160.1 3841368 R 574521 CDS YP_002331161.1 215488730 7061544 complement(3842083..3842850) 1 NC_011601.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3842850 livG 7061544 livG Escherichia coli O127:H6 str. E2348/69 leucine/isoleucine/valine transporter ATP-binding subunit YP_002331161.1 3842083 R 574521 CDS YP_002331162.1 215488731 7061545 complement(3842847..3844124) 1 NC_011601.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit 3844124 livM 7061545 livM Escherichia coli O127:H6 str. E2348/69 leucine/isoleucine/valine transporter permease subunit YP_002331162.1 3842847 R 574521 CDS YP_002331163.1 215488732 7061549 complement(3844121..3845047) 1 NC_011601.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH 3845047 livH 7061549 livH Escherichia coli O127:H6 str. E2348/69 branched-chain amino acid transporter permease subunit LivH YP_002331163.1 3844121 R 574521 CDS YP_002331164.1 215488733 7061546 complement(3845095..3846204) 1 NC_011601.1 leucine transporter subunit 3846204 livK 7061546 livK Escherichia coli O127:H6 str. E2348/69 leucine transporter subunit YP_002331164.1 3845095 R 574521 CDS YP_002331165.1 215488734 7061548 3846628..3847011 1 NC_011601.1 hypothetical protein 3847011 yhhK 7061548 yhhK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331165.1 3846628 D 574521 CDS YP_002331166.1 215488735 7064653 complement(3847199..3848302) 1 NC_011601.1 leucine/isoleucine/valine transporter subunit 3848302 livJ 7064653 livJ Escherichia coli O127:H6 str. E2348/69 leucine/isoleucine/valine transporter subunit YP_002331166.1 3847199 R 574521 CDS YP_002331167.1 215488736 7061547 complement(3848573..3849427) 1 NC_011601.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 3849427 rpoH 7061547 rpoH Escherichia coli O127:H6 str. E2348/69 RNA polymerase factor sigma-32 YP_002331167.1 3848573 R 574521 CDS YP_002331168.1 215488737 7061868 complement(3849672..3850730) 1 NC_011601.1 ABC transporter, membrane protein; cell division protein FtsX 3850730 ftsX 7061868 ftsX Escherichia coli O127:H6 str. E2348/69 cell division protein FtsX YP_002331168.1 3849672 R 574521 CDS YP_002331169.1 215488738 7061590 complement(3850723..3851391) 1 NC_011601.1 ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE 3851391 ftsE 7061590 ftsE Escherichia coli O127:H6 str. E2348/69 cell division protein FtsE YP_002331169.1 3850723 R 574521 CDS YP_002331170.1 215488739 7061583 complement(3851394..3852890) 1 NC_011601.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY 3852890 ftsY 7061583 ftsY Escherichia coli O127:H6 str. E2348/69 cell division protein FtsY YP_002331170.1 3851394 R 574521 CDS YP_002331171.1 215488740 7061591 3853040..3853636 1 NC_011601.1 catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 3853636 rsmD 7061591 rsmD Escherichia coli O127:H6 str. E2348/69 16S rRNA m(2)G966-methyltransferase YP_002331171.1 3853040 D 574521 CDS YP_002331172.1 215488741 7064557 3853626..3853895 1 NC_011601.1 hypothetical protein 3853895 yhhL 7064557 yhhL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331172.1 3853626 D 574521 CDS YP_002331173.1 215488742 7064654 complement(3853898..3854257) 1 NC_011601.1 hypothetical protein 3854257 yhhM 7064654 yhhM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331173.1 3853898 R 574521 CDS YP_002331174.1 215488743 7064655 3854398..3855024 1 NC_011601.1 hypothetical protein 3855024 yhhN 7064655 yhhN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331174.1 3854398 D 574521 CDS YP_002331175.1 215488744 7064656 3855098..3857296 1 NC_011601.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 3857296 zntA 7064656 zntA Escherichia coli O127:H6 str. E2348/69 zinc/cadmium/mercury/lead-transporting ATPase YP_002331175.1 3855098 D 574521 CDS YP_002331176.1 215488745 7061128 3857676..3859049 1 NC_011601.1 transposase of ISEc13 3859049 7061128 E2348C_3710 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002331176.1 3857676 D 574521 CDS YP_002331177.1 215488746 7062647 complement(3859124..3859369) 1 NC_011601.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 3859369 sirA 7062647 sirA Escherichia coli O127:H6 str. E2348/69 sulfur transfer protein SirA YP_002331177.1 3859124 R 574521 CDS YP_002331178.1 215488747 7062717 3859590..3860255 1 NC_011601.1 hypothetical protein 3860255 yhhQ 7062717 yhhQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331178.1 3859590 D 574521 CDS YP_002331179.1 215488748 7064657 3860286..3860885 1 NC_011601.1 hypothetical protein 3860885 dcrB 7064657 dcrB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331179.1 3860286 D 574521 CDS YP_002331180.1 215488749 7065229 complement(3860889..3862106) 1 NC_011601.1 major facilitator superfamily transporter 3862106 yhhS 7065229 yhhS Escherichia coli O127:H6 str. E2348/69 major facilitator superfamily transporter YP_002331180.1 3860889 R 574521 CDS YP_002331181.1 215488750 7064658 3862238..3863287 1 NC_011601.1 hypothetical protein 3863287 yhhT 7064658 yhhT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331181.1 3862238 D 574521 CDS YP_002331182.1 215488751 7064659 3863342..3863929 1 NC_011601.1 holo-(acyl carrier protein) synthase 2 3863929 acpT 7064659 acpT Escherichia coli O127:H6 str. E2348/69 holo-(acyl carrier protein) synthase 2 YP_002331182.1 3863342 D 574521 CDS YP_002331183.1 215488752 7062395 3864040..3865614 1 NC_011601.1 nickel transporter subunit 3865614 nikA 7062395 nikA Escherichia coli O127:H6 str. E2348/69 nickel transporter subunit YP_002331183.1 3864040 D 574521 CDS YP_002331184.1 215488753 7065391 3865614..3866558 1 NC_011601.1 with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 3866558 nikB 7065391 nikB Escherichia coli O127:H6 str. E2348/69 nickel transporter permease NikB YP_002331184.1 3865614 D 574521 CDS YP_002331185.1 215488754 7065392 3866555..3867388 1 NC_011601.1 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 3867388 nikC 7065392 nikC Escherichia coli O127:H6 str. E2348/69 nickel transporter permease NikC YP_002331185.1 3866555 D 574521 CDS YP_002331186.1 215488755 7065393 3867388..3868152 1 NC_011601.1 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 3868152 nikD 7065393 nikD Escherichia coli O127:H6 str. E2348/69 nickel transporter ATP-binding protein NikD YP_002331186.1 3867388 D 574521 CDS YP_002331187.1 215488756 7065394 3868149..3868955 1 NC_011601.1 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 3868955 nikE 7065394 nikE Escherichia coli O127:H6 str. E2348/69 nickel transporter ATP-binding protein NikE YP_002331187.1 3868149 D 574521 CDS YP_002331188.1 215488757 7065395 3868961..3869362 1 NC_011601.1 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 3869362 nikR 7065395 nikR Escherichia coli O127:H6 str. E2348/69 nickel responsive regulator YP_002331188.1 3868961 D 574521 CDS YP_002331189.1 215488758 7065396 complement(3869482..3869841) 1 NC_011601.1 HicB-like protein 3869841 7065396 E2348C_3723 Escherichia coli O127:H6 str. E2348/69 HicB-like protein YP_002331189.1 3869482 R 574521 CDS YP_002331190.1 215488759 7062648 complement(3869838..3870113) 1 NC_011601.1 HicA-like protein 3870113 7062648 E2348C_3724 Escherichia coli O127:H6 str. E2348/69 HicA-like protein YP_002331190.1 3869838 R 574521 CDS YP_002331191.1 215488760 7062649 complement(3870186..3871310) 1 NC_011601.1 transporter subunit: membrane component of ABC superfamily 3871310 yhhJ 7062649 yhhJ Escherichia coli O127:H6 str. E2348/69 transporter subunit: membrane component of ABC superfamily YP_002331191.1 3870186 R 574521 CDS YP_002331192.1 215488761 7064652 complement(3871310..3874045) 1 NC_011601.1 fused ribosome-associated ATPase RbbA: ATP-binding protein/ATP-binding protein/ membrane protein 3874045 rbbA 7064652 rbbA Escherichia coli O127:H6 str. E2348/69 fused ribosome-associated ATPase RbbA: ATP-binding protein/ATP-binding protein/ membrane protein YP_002331192.1 3871310 R 574521 CDS YP_002331193.1 215488762 7063951 complement(3874042..3875109) 1 NC_011601.1 HlyD family secretion protein 3875109 yhiI 7063951 yhiI Escherichia coli O127:H6 str. E2348/69 HlyD family secretion protein YP_002331193.1 3874042 R 574521 CDS YP_002331194.1 215488763 7064665 3875843..3876895 1 NC_011601.1 hypothetical protein 3876895 yhiM 7064665 yhiM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331194.1 3875843 D 574521 CDS YP_002331195.1 215488764 7064666 complement(3876982..3878175) 1 NC_011601.1 oxidoreductase with FAD/NAD(P)-binding domain 3878175 yhiN 7064666 yhiN Escherichia coli O127:H6 str. E2348/69 oxidoreductase with FAD/NAD(P)-binding domain YP_002331195.1 3876982 R 574521 CDS YP_002331196.1 215488765 7064667 3878407..3879906 1 NC_011601.1 phosphate transporter, low-affinity 3879906 pitA 7064667 pitA Escherichia coli O127:H6 str. E2348/69 phosphate transporter, low-affinity YP_002331196.1 3878407 D 574521 CDS YP_002331197.1 215488766 7060752 complement(3879977..3880312) 1 NC_011601.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB 3880312 uspB 7060752 uspB Escherichia coli O127:H6 str. E2348/69 universal stress protein UspB YP_002331197.1 3879977 R 574521 CDS YP_002331198.1 215488767 7062333 3880703..3881137 1 NC_011601.1 universal stress global response regulator 3881137 uspA 7062333 uspA Escherichia coli O127:H6 str. E2348/69 universal stress global response regulator YP_002331198.1 3880703 D 574521 CDS YP_002331199.1 215488768 7062332 3881454..3882923 1 NC_011601.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 3882923 yhiP 7062332 yhiP Escherichia coli O127:H6 str. E2348/69 inner membrane transporter YhiP YP_002331199.1 3881454 D 574521 CDS YP_002331200.1 215488769 7064668 complement(3882972..3883724) 1 NC_011601.1 SAM-dependent methyltransferase; methyltransferase 3883724 yhiQ 7064668 yhiQ Escherichia coli O127:H6 str. E2348/69 methyltransferase YP_002331200.1 3882972 R 574521 CDS YP_002331201.1 215488770 7064669 complement(3883732..3885774) 1 NC_011601.1 oligopeptidase A 3885774 prlC 7064669 prlC Escherichia coli O127:H6 str. E2348/69 oligopeptidase A YP_002331201.1 3883732 R 574521 CDS YP_002331202.1 215488771 7061292 3885977..3886819 1 NC_011601.1 DNA (exogenous) processing protein 3886819 yhiR 7061292 yhiR Escherichia coli O127:H6 str. E2348/69 DNA (exogenous) processing protein YP_002331202.1 3885977 D 574521 CDS YP_002331203.1 215488772 7064670 3886891..3888243 1 NC_011601.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 3888243 gor 7064670 gor Escherichia coli O127:H6 str. E2348/69 glutathione reductase YP_002331203.1 3886891 D 574521 CDS YP_002331204.1 215488773 7064232 complement(3888297..3888425) 1 NC_011601.1 damage inducible protein 3888425 dinQ 7064232 dinQ Escherichia coli O127:H6 str. E2348/69 damage inducible protein YP_002331204.1 3888297 R 574521 CDS YP_002331205.1 215488774 7065033 3888914..3889339 1 NC_011601.1 arsenate reductase 3889339 arsC 7065033 arsC Escherichia coli O127:H6 str. E2348/69 arsenate reductase YP_002331205.1 3888914 D 574521 CDS YP_002331206.1 215488775 7061401 3890523..3891089 1 NC_011601.1 outer membrane lipoprotein 3891089 slp 7061401 slp Escherichia coli O127:H6 str. E2348/69 outer membrane lipoprotein YP_002331206.1 3890523 D 574521 CDS YP_002331207.1 215488776 7062721 3891242..3891772 1 NC_011601.1 DNA-binding transcriptional regulator 3891772 yhiF 7062721 yhiF Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002331207.1 3891242 D 574521 CDS YP_002331208.1 215488777 7064664 complement(3891829..3892857) 1 NC_011601.1 heme/hemoglobin transport protein 3892857 chuS 7064664 chuS Escherichia coli O127:H6 str. E2348/69 heme/hemoglobin transport protein YP_002331208.1 3891829 R 574521 CDS YP_002331209.1 215488778 7062790 complement(3892906..3894888) 1 NC_011601.1 outer membrane heme/hemoglobin receptor 3894888 chuA 7062790 chuA Escherichia coli O127:H6 str. E2348/69 outer membrane heme/hemoglobin receptor YP_002331209.1 3892906 R 574521 CDS YP_002331210.1 215488779 7062789 3895572..3896486 1 NC_011601.1 hemin binding protein 3896486 chuT 7062789 chuT Escherichia coli O127:H6 str. E2348/69 hemin binding protein YP_002331210.1 3895572 D 574521 CDS YP_002331211.1 215488780 7062791 3896506..3897843 1 NC_011601.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3897843 chuW 7062791 chuW Escherichia coli O127:H6 str. E2348/69 coproporphyrinogen III oxidase YP_002331211.1 3896506 D 574521 CDS YP_002331212.1 215488781 7062793 3897856..3898350 1 NC_011601.1 ShuX-like protein 3898350 chuX 7062793 chuX Escherichia coli O127:H6 str. E2348/69 ShuX-like protein YP_002331212.1 3897856 D 574521 CDS YP_002331213.1 215488782 7062794 3898350..3898973 1 NC_011601.1 ShuY-like protein 3898973 chuY 7062794 chuY Escherichia coli O127:H6 str. E2348/69 ShuY-like protein YP_002331213.1 3898350 D 574521 CDS YP_002331214.1 215488783 7062795 3899058..3900014 1 NC_011601.1 hemin permease 3900014 chuU 7062795 chuU Escherichia coli O127:H6 str. E2348/69 hemin permease YP_002331214.1 3899058 D 574521 CDS YP_002331215.1 215488784 7062792 3900011..3900781 1 NC_011601.1 with HmuTU is involved in the transport of hemin; hemin importer ATP-binding subunit 3900781 hmuV 7062792 hmuV Escherichia coli O127:H6 str. E2348/69 hemin importer ATP-binding subunit YP_002331215.1 3900011 D 574521 CDS YP_002331216.1 215488785 7062650 complement(3900833..3901480) 1 NC_011601.1 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; Mg(2+) transport ATPase 3901480 yhiD 7062650 yhiD Escherichia coli O127:H6 str. E2348/69 Mg(2+) transport ATPase YP_002331216.1 3900833 R 574521 CDS YP_002331217.1 215488786 7064663 complement(3901544..3901882) 1 NC_011601.1 acid-resistance protein 3901882 hdeB 7064663 hdeB Escherichia coli O127:H6 str. E2348/69 acid-resistance protein YP_002331217.1 3901544 R 574521 CDS YP_002331218.1 215488787 7064286 complement(3901986..3902318) 1 NC_011601.1 inactive form; acid-resistance protein 3902318 hdeA 7064286 hdeA Escherichia coli O127:H6 str. E2348/69 acid-resistance protein YP_002331218.1 3901986 R 574521 CDS YP_002331219.1 215488788 7064285 3902573..3903145 1 NC_011601.1 acid-resistance membrane protein 3903145 hdeD 7064285 hdeD Escherichia coli O127:H6 str. E2348/69 acid-resistance membrane protein YP_002331219.1 3902573 D 574521 CDS YP_002331220.1 215488789 7064287 3903944..3904471 1 NC_011601.1 DNA-binding transcriptional activator 3904471 gadE 7064287 gadE Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator YP_002331220.1 3903944 D 574521 CDS YP_002331221.1 215488790 7061612 3904810..3905967 1 NC_011601.1 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 3905967 mdtE 7061612 mdtE Escherichia coli O127:H6 str. E2348/69 multidrug efflux system protein MdtE YP_002331221.1 3904810 D 574521 CDS YP_002331222.1 215488791 7065310 3905992..3909105 1 NC_011601.1 multidrug transporter, RpoS-dependent 3909105 mdtF 7065310 mdtF Escherichia coli O127:H6 str. E2348/69 multidrug transporter, RpoS-dependent YP_002331222.1 3905992 D 574521 CDS YP_002331223.1 215488792 7065311 complement(3909468..3910196) 1 NC_011601.1 DNA-binding transcriptional activator 3910196 gadW 7065311 gadW Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator YP_002331223.1 3909468 R 574521 CDS YP_002331224.1 215488793 7061615 complement(3910565..3911389) 1 NC_011601.1 regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 3911389 gadX 7061615 gadX Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator GadX YP_002331224.1 3910565 R 574521 CDS YP_002331225.1 215488794 7061614 complement(3911757..3913157) 1 NC_011601.1 glutamate decarboxylase 3913157 gadA 7061614 gadA Escherichia coli O127:H6 str. E2348/69 glutamate decarboxylase YP_002331225.1 3911757 R 574521 CDS YP_002331226.1 215488795 7061609 complement(3913368..3914765) 1 NC_011601.1 cytochrome C peroxidase 3914765 yhjA 7061609 yhjA Escherichia coli O127:H6 str. E2348/69 cytochrome C peroxidase YP_002331226.1 3913368 R 574521 CDS YP_002331227.1 215488796 7064671 3915170..3916819 1 NC_011601.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 3916819 treF 7064671 treF Escherichia coli O127:H6 str. E2348/69 trehalase YP_002331227.1 3915170 D 574521 CDS YP_002331228.1 215488797 7062236 complement(3916870..3917472) 1 NC_011601.1 DNA-binding response regulator in two-component regulatory system 3917472 yhjB 7062236 yhjB Escherichia coli O127:H6 str. E2348/69 DNA-binding response regulator in two-component regulatory system YP_002331228.1 3916870 R 574521 CDS YP_002331229.1 215488798 7064672 3917920..3918891 1 NC_011601.1 DNA-binding transcriptional regulator 3918891 yhjC 7064672 yhjC Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002331229.1 3917920 D 574521 CDS YP_002331230.1 215488799 7064673 3918940..3919953 1 NC_011601.1 hypothetical protein 3919953 yhjD 7064673 yhjD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331230.1 3918940 D 574521 CDS YP_002331231.1 215488800 7064674 3920346..3921668 1 NC_011601.1 transporter 3921668 yhjE 7064674 yhjE Escherichia coli O127:H6 str. E2348/69 transporter YP_002331231.1 3920346 D 574521 CDS YP_002331232.1 215488801 7064675 complement(3921709..3923784) 1 NC_011601.1 outer membrane biogenesis protein 3923784 yhjG 7064675 yhjG Escherichia coli O127:H6 str. E2348/69 outer membrane biogenesis protein YP_002331232.1 3921709 R 574521 CDS YP_002331233.1 215488802 7064676 complement(3923839..3924606) 1 NC_011601.1 in Escherichia coli this protein is involved in flagellar function; diguanylate phosphodiesterase 3924606 yhjH 7064676 yhjH Escherichia coli O127:H6 str. E2348/69 diguanylate phosphodiesterase YP_002331233.1 3923839 R 574521 CDS YP_002331234.1 215488803 7064677 3924838..3925767 1 NC_011601.1 ketodeoxygluconokinase 3925767 kdgK 7064677 kdgK Escherichia coli O127:H6 str. E2348/69 ketodeoxygluconokinase YP_002331234.1 3924838 D 574521 CDS YP_002331235.1 215488804 7063569 complement(3925863..3927359) 1 NC_011601.1 zinc-dependent peptidase 3927359 yhjJ 7063569 yhjJ Escherichia coli O127:H6 str. E2348/69 zinc-dependent peptidase YP_002331235.1 3925863 R 574521 CDS YP_002331236.1 215488805 7064678 complement(3927580..3928866) 1 NC_011601.1 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 3928866 dctA 7064678 dctA Escherichia coli O127:H6 str. E2348/69 C4-dicarboxylate transporter DctA YP_002331236.1 3927580 R 574521 CDS YP_002331237.1 215488806 7065230 complement(3929049..3931004) 1 NC_011601.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase from E. coli; phosphodiesterase 3931004 yhjK 7065230 yhjK Escherichia coli O127:H6 str. E2348/69 phosphodiesterase YP_002331237.1 3929049 R 574521 CDS YP_002331238.1 215488807 7064679 complement(3931119..3934592) 1 NC_011601.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC 3934592 bcsC 7064679 bcsC Escherichia coli O127:H6 str. E2348/69 cellulose synthase subunit BcsC YP_002331238.1 3931119 R 574521 CDS YP_002331239.1 215488808 7062501 complement(3934574..3935680) 1 NC_011601.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase 3935680 bcsZ 7062501 bcsZ Escherichia coli O127:H6 str. E2348/69 endo-1,4-D-glucanase YP_002331239.1 3934574 R 574521 CDS YP_002331240.1 215488809 7062504 complement(3935687..3938026) 1 NC_011601.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein 3938026 bcsB 7062504 bcsB Escherichia coli O127:H6 str. E2348/69 cellulose synthase regulator protein YP_002331240.1 3935687 R 574521 CDS YP_002331241.1 215488810 7062500 complement(3938037..3940655) 1 NC_011601.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit 3940655 bcsA 7062500 bcsA Escherichia coli O127:H6 str. E2348/69 cellulose synthase catalytic subunit YP_002331241.1 3938037 R 574521 CDS YP_002331242.1 215488811 7062499 complement(3940652..3941404) 1 NC_011601.1 cell division protein 3941404 yhjQ 7062499 yhjQ Escherichia coli O127:H6 str. E2348/69 cell division protein YP_002331242.1 3940652 R 574521 CDS YP_002331243.1 215488812 7064680 complement(3941416..3941604) 1 NC_011601.1 hypothetical protein 3941604 yhjR 7064680 yhjR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331243.1 3941416 R 574521 CDS YP_002331244.1 215488813 7064681 3941877..3943448 1 NC_011601.1 hypothetical protein 3943448 bcsE 7064681 bcsE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331244.1 3941877 D 574521 CDS YP_002331245.1 215488814 7062502 3943445..3943636 1 NC_011601.1 hypothetical protein 3943636 bcsF 7062502 bcsF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331245.1 3943445 D 574521 CDS YP_002331246.1 215488815 7062503 3943633..3945312 1 NC_011601.1 hypothetical protein 3945312 bcsG 7062503 bcsG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331246.1 3943633 D 574521 CDS YP_002331247.1 215488816 7061129 complement(3945427..3945885) 1 NC_011601.1 transposase of IS200C 3945885 7061129 E2348C_3781 Escherichia coli O127:H6 str. E2348/69 transposase of IS200C YP_002331247.1 3945427 R 574521 CDS YP_002331248.1 215488817 7062651 complement(3946109..3946216) 1 NC_011601.1 small toxic polypeptide ldrD 1 3946216 ldrD1 7062651 ldrD1 Escherichia coli O127:H6 str. E2348/69 small toxic polypeptide ldrD 1 YP_002331248.1 3946109 R 574521 CDS YP_002331249.1 215488818 7063972 complement(3946592..3946699) 1 NC_011601.1 small toxic polypeptide ldrD 2 3946699 ldrD2 7063972 ldrD2 Escherichia coli O127:H6 str. E2348/69 small toxic polypeptide ldrD 2 YP_002331249.1 3946592 R 574521 CDS YP_002331250.1 215488819 7063973 3947175..3948446 1 NC_011601.1 transporter 3948446 yhjV 7063973 yhjV Escherichia coli O127:H6 str. E2348/69 transporter YP_002331250.1 3947175 D 574521 CDS YP_002331251.1 215488820 7064682 complement(3948463..3949470) 1 NC_011601.1 hypothetical protein 3949470 7064682 E2348C_3785 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331251.1 3948463 R 574521 CDS YP_002331252.1 215488821 7062652 complement(3949470..3949781) 1 NC_011601.1 hypothetical protein 3949781 7062652 E2348C_3786 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331252.1 3949470 R 574521 CDS YP_002331253.1 215488822 7062653 complement(3949766..3950089) 1 NC_011601.1 transcriptional regulator, XRE family 3950089 7062653 E2348C_3787 Escherichia coli O127:H6 str. E2348/69 transcriptional regulator, XRE family YP_002331253.1 3949766 R 574521 CDS YP_002331254.1 215488823 7062654 complement(3950314..3951327) 1 NC_011601.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 3951327 dppF 7062654 dppF Escherichia coli O127:H6 str. E2348/69 dipeptide transporter ATP-binding subunit YP_002331254.1 3950314 R 574521 CDS YP_002331255.1 215488824 7065060 complement(3951324..3952307) 1 NC_011601.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 3952307 dppD 7065060 dppD Escherichia coli O127:H6 str. E2348/69 dipeptide transporter ATP-binding subunit YP_002331255.1 3951324 R 574521 CDS YP_002331256.1 215488825 7065059 complement(3952318..3953220) 1 NC_011601.1 dipeptide transporter 3953220 dppC 7065059 dppC Escherichia coli O127:H6 str. E2348/69 dipeptide transporter YP_002331256.1 3952318 R 574521 CDS YP_002331257.1 215488826 7065058 complement(3953230..3954249) 1 NC_011601.1 transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB 3954249 dppB 7065058 dppB Escherichia coli O127:H6 str. E2348/69 dipeptide transporter permease DppB YP_002331257.1 3953230 R 574521 CDS YP_002331258.1 215488827 7065057 complement(3954557..3956164) 1 NC_011601.1 dipeptide transporter 3956164 dppA 7065057 dppA Escherichia coli O127:H6 str. E2348/69 dipeptide transporter YP_002331258.1 3954557 R 574521 CDS YP_002331259.1 215488828 7061299 complement(3957076..3958767) 1 NC_011601.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase 3958767 eptB 7061299 eptB Escherichia coli O127:H6 str. E2348/69 phosphoethanolamine transferase YP_002331259.1 3957076 R 574521 CDS YP_002331260.1 215488829 7063864 complement(3959031..3959561) 1 NC_011601.1 fimbrial protein 3959561 lpfE 7063864 lpfE Escherichia coli O127:H6 str. E2348/69 fimbrial protein YP_002331260.1 3959031 R 574521 CDS YP_002331261.1 215488830 7061566 complement(3959567..3960622) 1 NC_011601.1 fimbrial protein 3960622 lpfD 7061566 lpfD Escherichia coli O127:H6 str. E2348/69 fimbrial protein YP_002331261.1 3959567 R 574521 CDS YP_002331262.1 215488831 7061565 complement(3960638..3963217) 1 NC_011601.1 fimbrial usher protein 3963217 lpfC 7061565 lpfC Escherichia coli O127:H6 str. E2348/69 fimbrial usher protein YP_002331262.1 3960638 R 574521 CDS YP_002331263.1 215488832 7061564 complement(3963241..3963894) 1 NC_011601.1 fimbrial chaperone 3963894 lpfB 7061564 lpfB Escherichia coli O127:H6 str. E2348/69 fimbrial chaperone YP_002331263.1 3963241 R 574521 CDS YP_002331264.1 215488833 7061563 complement(3963994..3964518) 1 NC_011601.1 fimbrial major protein 3964518 lpfA 7061563 lpfA Escherichia coli O127:H6 str. E2348/69 fimbrial major protein YP_002331264.1 3963994 R 574521 CDS YP_002331265.1 215488834 7061562 complement(3964865..3966067) 1 NC_011601.1 transporter 3966067 yhjX 7061562 yhjX Escherichia coli O127:H6 str. E2348/69 transporter YP_002331265.1 3964865 R 574521 CDS YP_002331266.1 215488835 7061499 3967156..3967719 1 NC_011601.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyladenine DNA glycosylase 3967719 tag 7061499 tag Escherichia coli O127:H6 str. E2348/69 3-methyladenine DNA glycosylase YP_002331266.1 3967156 D 574521 CDS YP_002331267.1 215488836 7061748 3967716..3968156 1 NC_011601.1 hypothetical protein 3968156 yiaC 7061748 yiaC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331267.1 3967716 D 574521 CDS YP_002331268.1 215488837 7062527 3970429..3971088 1 NC_011601.1 outer membrane lipoprotein 3971088 yiaD 7062527 yiaD Escherichia coli O127:H6 str. E2348/69 outer membrane lipoprotein YP_002331268.1 3970429 D 574521 CDS YP_002331269.1 215488838 7064767 3971192..3972166 1 NC_011601.1 2-keto-D-gluconate reductase (glyoxalatereductase) (2-ketoaldonate reductase) 3972166 ghrB 7064767 ghrB Escherichia coli O127:H6 str. E2348/69 2-keto-D-gluconate reductase (glyoxalatereductase) (2-ketoaldonate reductase) YP_002331269.1 3971192 D 574521 CDS YP_002331270.1 215488839 7061655 complement(3972216..3972926) 1 NC_011601.1 hypothetical protein 3972926 yiaF 7061655 yiaF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331270.1 3972216 R 574521 CDS YP_002331271.1 215488840 7064768 3973360..3973650 1 NC_011601.1 transcriptional regulator 3973650 yiaG 7064768 yiaG Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002331271.1 3973360 D 574521 CDS YP_002331272.1 215488841 7064769 3973931..3974143 1 NC_011601.1 major cold shock protein 3974143 cspA 7064769 cspA Escherichia coli O127:H6 str. E2348/69 major cold shock protein YP_002331272.1 3973931 D 574521 CDS YP_002331273.1 215488842 7062860 complement(3974331..3974483) 1 NC_011601.1 small toxic polypeptide 3974483 hokA 7062860 hokA Escherichia coli O127:H6 str. E2348/69 small toxic polypeptide YP_002331273.1 3974331 R 574521 CDS YP_002331274.1 215488843 7062168 complement(3974806..3976875) 1 NC_011601.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 3976875 glyS 7062168 glyS Escherichia coli O127:H6 str. E2348/69 glycyl-tRNA synthetase subunit beta YP_002331274.1 3974806 R 574521 CDS YP_002331275.1 215488844 7061722 complement(3976885..3977796) 1 NC_011601.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 3977796 glyQ 7061722 glyQ Escherichia coli O127:H6 str. E2348/69 glycyl-tRNA synthetase subunit alpha YP_002331275.1 3976885 R 574521 CDS YP_002331276.1 215488845 7061721 complement(3977891..3978190) 1 NC_011601.1 hypothetical protein 3978190 ysaB 7061721 ysaB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331276.1 3977891 R 574521 CDS YP_002331277.1 215488846 7063236 3978365..3979360 1 NC_011601.1 hypothetical protein 3979360 wecH 7063236 wecH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331277.1 3978365 D 574521 CDS YP_002331278.1 215488847 7064844 complement(3979401..3979838) 1 NC_011601.1 hypothetical protein 3979838 yiaA 7064844 yiaA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331278.1 3979401 R 574521 CDS YP_002331279.1 215488848 7064764 complement(3979884..3980225) 1 NC_011601.1 hypothetical protein 3980225 yiaB 7064764 yiaB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331279.1 3979884 R 574521 CDS YP_002331280.1 215488849 7064765 complement(3980394..3981848) 1 NC_011601.1 xylulokinase 3981848 xylB 7064765 xylB Escherichia coli O127:H6 str. E2348/69 xylulokinase YP_002331280.1 3980394 R 574521 CDS YP_002331281.1 215488850 7064870 complement(3981920..3983242) 1 NC_011601.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 3983242 xylA 7064870 xylA Escherichia coli O127:H6 str. E2348/69 xylose isomerase YP_002331281.1 3981920 R 574521 CDS YP_002331282.1 215488851 7064869 3983608..3984600 1 NC_011601.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 3984600 xylF 7064869 xylF Escherichia coli O127:H6 str. E2348/69 D-xylose transporter subunit XylF YP_002331282.1 3983608 D 574521 CDS YP_002331283.1 215488852 7064871 3984678..3986219 1 NC_011601.1 with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 3986219 xylG 7064871 xylG Escherichia coli O127:H6 str. E2348/69 xylose transporter ATP-binding subunit YP_002331283.1 3984678 D 574521 CDS YP_002331284.1 215488853 7064872 3986197..3987378 1 NC_011601.1 xylose transport, membrane component; membrane component of ABC superfamily XylH 3987378 xylH 7064872 xylH Escherichia coli O127:H6 str. E2348/69 xylose transport, membrane component; membrane component of ABC superfamily XylH YP_002331284.1 3986197 D 574521 CDS YP_002331285.1 215488854 7064873 3987456..3988634 1 NC_011601.1 DNA-binding transcriptional activator, xylose-binding 3988634 xylR 7064873 xylR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator, xylose-binding YP_002331285.1 3987456 D 574521 CDS YP_002331286.1 215488855 7064874 complement(3988742..3989566) 1 NC_011601.1 hypothetical protein 3989566 bax 7064874 bax Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331286.1 3988742 R 574521 CDS YP_002331287.1 215488856 7062496 3989886..3991916 1 NC_011601.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 3991916 malS 7062496 malS Escherichia coli O127:H6 str. E2348/69 periplasmic alpha-amylase YP_002331287.1 3989886 D 574521 CDS YP_002331288.1 215488857 7065278 3992094..3993347 1 NC_011601.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 3993347 avtA 7065278 avtA Escherichia coli O127:H6 str. E2348/69 valine--pyruvate transaminase YP_002331288.1 3992094 D 574521 CDS YP_002331289.1 215488858 7062488 complement(3993499..3993972) 1 NC_011601.1 hydrogenase, 4Fe-4S ferredoxin-type component 3993972 ysaA 7062488 ysaA Escherichia coli O127:H6 str. E2348/69 hydrogenase, 4Fe-4S ferredoxin-type component YP_002331289.1 3993499 R 574521 CDS YP_002331290.1 215488859 7063235 complement(3994074..3994922) 1 NC_011601.1 DNA-binding transcriptional repressor 3994922 yiaJ 7063235 yiaJ Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor YP_002331290.1 3994074 R 574521 CDS YP_002331291.1 215488860 7064770 3995123..3996121 1 NC_011601.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 3996121 yiaK 7064770 yiaK Escherichia coli O127:H6 str. E2348/69 2,3-diketo-L-gulonate reductase YP_002331291.1 3995123 D 574521 CDS YP_002331292.1 215488861 7064771 3996133..3996597 1 NC_011601.1 hypothetical protein 3996597 yiaL 7064771 yiaL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331292.1 3996133 D 574521 CDS YP_002331293.1 215488862 7064772 3996620..3997540 1 NC_011601.1 hypothetical protein 3997540 7064772 E2348C_3829 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331293.1 3996620 D 574521 CDS YP_002331294.1 215488863 7062655 3997654..3998121 1 NC_011601.1 membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO; 2,3-diketo-L-gulonate TRAP transporter small permease YiaM 3998121 yiaM 7062655 yiaM Escherichia coli O127:H6 str. E2348/69 2,3-diketo-L-gulonate TRAP transporter small permease YiaM YP_002331294.1 3997654 D 574521 CDS YP_002331295.1 215488864 7064773 3998124..3999401 1 NC_011601.1 transporter, large permease component 3999401 yiaN 7064773 yiaN Escherichia coli O127:H6 str. E2348/69 transporter, large permease component YP_002331295.1 3998124 D 574521 CDS YP_002331296.1 215488865 7064774 3999414..4000400 1 NC_011601.1 transporter, periplasmic protein 4000400 yiaO 7064774 yiaO Escherichia coli O127:H6 str. E2348/69 transporter, periplasmic protein YP_002331296.1 3999414 D 574521 CDS YP_002331297.1 215488866 7064775 4000404..4001900 1 NC_011601.1 L-xylulose kinase 4001900 lyx 7064775 lyx Escherichia coli O127:H6 str. E2348/69 L-xylulose kinase YP_002331297.1 4000404 D 574521 CDS YP_002331298.1 215488867 7065263 4001897..4002559 1 NC_011601.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 4002559 sgbH 7065263 sgbH Escherichia coli O127:H6 str. E2348/69 3-keto-L-gulonate-6-phosphate decarboxylase YP_002331298.1 4001897 D 574521 CDS YP_002331299.1 215488868 7062712 4002552..4003412 1 NC_011601.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase 4003412 sgbU 7062712 sgbU Escherichia coli O127:H6 str. E2348/69 L-xylulose 5-phosphate 3-epimerase YP_002331299.1 4002552 D 574521 CDS YP_002331300.1 215488869 7062713 4003406..4004101 1 NC_011601.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4004101 sgbE 7062713 sgbE Escherichia coli O127:H6 str. E2348/69 L-ribulose-5-phosphate 4-epimerase YP_002331300.1 4003406 D 574521 CDS YP_002331301.1 215488870 7062711 complement(4004148..4005686) 1 NC_011601.1 aldehyde dehydrogenase 4005686 aldB 7062711 aldB Escherichia coli O127:H6 str. E2348/69 aldehyde dehydrogenase YP_002331301.1 4004148 R 574521 CDS YP_002331302.1 215488871 7062436 complement(4005794..4007089) 1 NC_011601.1 hypothetical protein 4007089 7062436 E2348C_3838 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331302.1 4005794 R 574521 CDS YP_002331303.1 215488872 7062656 complement(4007219..4008370) 1 NC_011601.1 alcohol dehydrogenase 4008370 yiaY 7062656 yiaY Escherichia coli O127:H6 str. E2348/69 alcohol dehydrogenase YP_002331303.1 4007219 R 574521 CDS YP_002331304.1 215488873 7064776 complement(4008559..4010403) 1 NC_011601.1 selenocysteinyl-tRNA-specific translation factor 4010403 selB 7064776 selB Escherichia coli O127:H6 str. E2348/69 selenocysteinyl-tRNA-specific translation factor YP_002331304.1 4008559 R 574521 CDS YP_002331305.1 215488874 7065361 complement(4010400..4011791) 1 NC_011601.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 4011791 selA 7065361 selA Escherichia coli O127:H6 str. E2348/69 selenocysteine synthase YP_002331305.1 4010400 R 574521 CDS YP_002331306.1 215488875 7065360 complement(4011889..4012497) 1 NC_011601.1 glutathione S-transferase 4012497 yibF 7065360 yibF Escherichia coli O127:H6 str. E2348/69 glutathione S-transferase YP_002331306.1 4011889 R 574521 CDS YP_002331307.1 215488876 7064778 complement(4012568..4013704) 1 NC_011601.1 hypothetical protein 4013704 yibH 7064778 yibH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331307.1 4012568 R 574521 CDS YP_002331308.1 215488877 7064779 complement(4013707..4014069) 1 NC_011601.1 hypothetical protein 4014069 yibI 7064779 yibI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331308.1 4013707 R 574521 CDS YP_002331309.1 215488878 7064780 4014606..4016519 1 NC_011601.1 fused mannitol-specific PTS enzymes: IIA components /IIB components/IIC components 4016519 mtlA 7064780 mtlA Escherichia coli O127:H6 str. E2348/69 fused mannitol-specific PTS enzymes: IIA components /IIB components/IIC components YP_002331309.1 4014606 D 574521 CDS YP_002331310.1 215488879 7060879 4016737..4017885 1 NC_011601.1 mannitol-1-phosphate 5-dehydrogenase 4017885 mtlD 7060879 mtlD Escherichia coli O127:H6 str. E2348/69 mannitol-1-phosphate 5-dehydrogenase YP_002331310.1 4016737 D 574521 CDS YP_002331311.1 215488880 7060880 4017885..4018472 1 NC_011601.1 Acts as a repressor of the mtlAD operon; mannitol repressor protein 4018472 mtlR 7060880 mtlR Escherichia coli O127:H6 str. E2348/69 mannitol repressor protein YP_002331311.1 4017885 D 574521 CDS YP_002331312.1 215488881 7060881 complement(4018483..4018692) 1 NC_011601.1 hypothetical protein 4018692 yibT 7060881 yibT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331312.1 4018483 R 574521 CDS YP_002331313.1 215488882 7064785 4018976..4019338 1 NC_011601.1 hypothetical protein 4019338 yibL 7064785 yibL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331313.1 4018976 D 574521 CDS YP_002331314.1 215488883 7062658 4025092..4026747 1 NC_011601.1 L-lactate permease 4026747 lldP 7062658 lldP Escherichia coli O127:H6 str. E2348/69 L-lactate permease YP_002331314.1 4025092 D 574521 CDS YP_002331315.1 215488884 7061551 4026747..4027523 1 NC_011601.1 represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4027523 lldR 7061551 lldR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor LldR YP_002331315.1 4026747 D 574521 CDS YP_002331316.1 215488885 7061552 4027520..4028710 1 NC_011601.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4028710 lldD 7061552 lldD Escherichia coli O127:H6 str. E2348/69 L-lactate dehydrogenase YP_002331316.1 4027520 D 574521 CDS YP_002331317.1 215488886 7061550 4028758..4029231 1 NC_011601.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK 4029231 yibK 7061550 yibK Escherichia coli O127:H6 str. E2348/69 tRNA/rRNA methyltransferase YibK YP_002331317.1 4028758 D 574521 CDS YP_002331318.1 215488887 7064781 complement(4029284..4030105) 1 NC_011601.1 catalyzes the O-acetylation of serine; serine acetyltransferase 4030105 cysE 7064781 cysE Escherichia coli O127:H6 str. E2348/69 serine acetyltransferase YP_002331318.1 4029284 R 574521 CDS YP_002331319.1 215488888 7065197 complement(4030185..4031204) 1 NC_011601.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 4031204 gpsA 7065197 gpsA Escherichia coli O127:H6 str. E2348/69 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_002331319.1 4030185 R 574521 CDS YP_002331320.1 215488889 7064237 complement(4031204..4031671) 1 NC_011601.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 4031671 secB 7064237 secB Escherichia coli O127:H6 str. E2348/69 preprotein translocase subunit SecB YP_002331320.1 4031204 R 574521 CDS YP_002331321.1 215488890 7065353 complement(4031735..4031986) 1 NC_011601.1 glutaredoxin 3 4031986 grxC 7065353 grxC Escherichia coli O127:H6 str. E2348/69 glutaredoxin 3 YP_002331321.1 4031735 R 574521 CDS YP_002331322.1 215488891 7064248 complement(4032127..4032558) 1 NC_011601.1 rhodanese-related sulfurtransferase 4032558 yibN 7064248 yibN Escherichia coli O127:H6 str. E2348/69 rhodanese-related sulfurtransferase YP_002331322.1 4032127 R 574521 CDS YP_002331323.1 215488892 7064783 4032803..4034347 1 NC_011601.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4034347 gpmM 7064783 gpmM Escherichia coli O127:H6 str. E2348/69 phosphoglyceromutase YP_002331323.1 4032803 D 574521 CDS YP_002331324.1 215488893 7064235 4034381..4035640 1 NC_011601.1 hypothetical protein 4035640 envC 7064235 envC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331324.1 4034381 D 574521 CDS YP_002331325.1 215488894 7063859 4035644..4036603 1 NC_011601.1 polysaccharide deacetylase 4036603 yibQ 7063859 yibQ Escherichia coli O127:H6 str. E2348/69 polysaccharide deacetylase YP_002331325.1 4035644 D 574521 CDS YP_002331326.1 215488895 7064784 complement(4036590..4037624) 1 NC_011601.1 glycosyl transferase family protein 4037624 yibD 7064784 yibD Escherichia coli O127:H6 str. E2348/69 glycosyl transferase family protein YP_002331326.1 4036590 R 574521 CDS YP_002331327.1 215488896 7064777 complement(4037863..4038888) 1 NC_011601.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 4038888 tdh 7064777 tdh Escherichia coli O127:H6 str. E2348/69 L-threonine 3-dehydrogenase YP_002331327.1 4037863 R 574521 CDS YP_002331328.1 215488897 7061773 complement(4038898..4040094) 1 NC_011601.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate CoA ligase 4040094 kbl 7061773 kbl Escherichia coli O127:H6 str. E2348/69 2-amino-3-ketobutyrate CoA ligase YP_002331328.1 4038898 R 574521 CDS YP_002331329.1 215488898 7063567 4040308..4041240 1 NC_011601.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 4041240 rfaD 7063567 rfaD Escherichia coli O127:H6 str. E2348/69 ADP-L-glycero-D-manno-heptose-6-epimerase YP_002331329.1 4040308 D 574521 CDS YP_002331330.1 215488899 7060781 4041250..4042296 1 NC_011601.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose--LPS heptosyltransferase 4042296 rfaF 7060781 rfaF Escherichia coli O127:H6 str. E2348/69 ADP-heptose--LPS heptosyltransferase YP_002331330.1 4041250 D 574521 CDS YP_002331331.1 215488900 7060783 4042300..4043259 1 NC_011601.1 ADP-heptose--LPS heptosyltransferase 4043259 rfaC 7060783 rfaC Escherichia coli O127:H6 str. E2348/69 ADP-heptose--LPS heptosyltransferase YP_002331331.1 4042300 D 574521 CDS YP_002331332.1 215488901 7060780 4043293..4044510 1 NC_011601.1 lipid A-core: surface polymer ligase 4044510 rfaL 7060780 rfaL Escherichia coli O127:H6 str. E2348/69 lipid A-core: surface polymer ligase YP_002331332.1 4043293 D 574521 CDS YP_002331333.1 215488902 7060788 complement(4044564..4045706) 1 NC_011601.1 lipopolysaccharide 1,2-N-acetylglucosamine transferase 4045706 7060788 E2348C_3871 Escherichia coli O127:H6 str. E2348/69 lipopolysaccharide 1,2-N-acetylglucosamine transferase YP_002331333.1 4044564 R 574521 CDS YP_002331334.1 215488903 7062659 complement(4045794..4046567) 1 NC_011601.1 lipopolysaccharide core biosynthesis protein 4046567 rfaZ 7062659 rfaZ Escherichia coli O127:H6 str. E2348/69 lipopolysaccharide core biosynthesis protein YP_002331334.1 4045794 R 574521 CDS YP_002331335.1 215488904 7060793 complement(4046641..4047339) 1 NC_011601.1 lipopolysaccharide core biosynthesis protein 4047339 rfaY 7060793 rfaY Escherichia coli O127:H6 str. E2348/69 lipopolysaccharide core biosynthesis protein YP_002331335.1 4046641 R 574521 CDS YP_002331336.1 215488905 7060792 complement(4047357..4048373) 1 NC_011601.1 UDP-D-glucose: (galactosyl) lipopolysaccharide glucosyltransferase 4048373 rfaJ 7060792 rfaJ Escherichia coli O127:H6 str. E2348/69 UDP-D-glucose: (galactosyl) lipopolysaccharide glucosyltransferase YP_002331336.1 4047357 R 574521 CDS YP_002331337.1 215488906 7060787 complement(4048413..4049432) 1 NC_011601.1 UDP-D-galactose: (glucosyl) lipopolysaccharide-alpha-1,3-D-galactosyltransferase 4049432 rfaI 7060787 rfaI Escherichia coli O127:H6 str. E2348/69 UDP-D-galactose: (glucosyl) lipopolysaccharide-alpha-1,3-D-galactosyltransferase YP_002331337.1 4048413 R 574521 CDS YP_002331338.1 215488907 7060786 complement(4049432..4050541) 1 NC_011601.1 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase 4050541 rfaB 7060786 rfaB Escherichia coli O127:H6 str. E2348/69 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase YP_002331338.1 4049432 R 574521 CDS YP_002331339.1 215488908 7060779 complement(4050555..4051490) 1 NC_011601.1 lipopolysaccharide core biosynthesis protein 4051490 rfaS 7060779 rfaS Escherichia coli O127:H6 str. E2348/69 lipopolysaccharide core biosynthesis protein YP_002331339.1 4050555 R 574521 CDS YP_002331340.1 215488909 7060791 complement(4051527..4052324) 1 NC_011601.1 lipopolysaccharide core biosynthesis heptosyl-I-kinase 4052324 rfaP 7060791 rfaP Escherichia coli O127:H6 str. E2348/69 lipopolysaccharide core biosynthesis heptosyl-I-kinase YP_002331340.1 4051527 R 574521 CDS YP_002331341.1 215488910 7060789 complement(4052317..4053441) 1 NC_011601.1 lipopolysaccharide core biosynthesis glucosyl transferase I 4053441 rfaG 7060789 rfaG Escherichia coli O127:H6 str. E2348/69 lipopolysaccharide core biosynthesis glucosyl transferase I YP_002331341.1 4052317 R 574521 CDS YP_002331342.1 215488911 7060784 complement(4053438..4054460) 1 NC_011601.1 lipopolysaccharide core biosynthesis protein 4054460 rfaQ 7060784 rfaQ Escherichia coli O127:H6 str. E2348/69 lipopolysaccharide core biosynthesis protein YP_002331342.1 4053438 R 574521 CDS YP_002331343.1 215488912 7060790 4054910..4056187 1 NC_011601.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 4056187 waaA 7060790 waaA Escherichia coli O127:H6 str. E2348/69 3-deoxy-D-manno-octulosonic-acid transferase YP_002331343.1 4054910 D 574521 CDS YP_002331344.1 215488913 7062364 4056195..4056674 1 NC_011601.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 4056674 coaD 7062364 coaD Escherichia coli O127:H6 str. E2348/69 phosphopantetheine adenylyltransferase YP_002331344.1 4056195 D 574521 CDS YP_002331345.1 215488914 7062822 complement(4056713..4057522) 1 NC_011601.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 4057522 mutM 7062822 mutM Escherichia coli O127:H6 str. E2348/69 formamidopyrimidine-DNA glycosylase YP_002331345.1 4056713 R 574521 CDS YP_002331346.1 215488915 7060899 complement(4057620..4057787) 1 NC_011601.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 4057787 rpmG 7060899 rpmG Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L33 YP_002331346.1 4057620 R 574521 CDS YP_002331347.1 215488916 7061859 complement(4057808..4058044) 1 NC_011601.1 required for 70S ribosome assembly; 50S ribosomal protein L28 4058044 rpmB 7061859 rpmB Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L28 YP_002331347.1 4057808 R 574521 CDS YP_002331348.1 215488917 7061854 complement(4058261..4058929) 1 NC_011601.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 4058929 radC 7061854 radC Escherichia coli O127:H6 str. E2348/69 DNA repair protein RadC YP_002331348.1 4058261 R 574521 CDS YP_002331349.1 215488918 7064795 4059101..4060321 1 NC_011601.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 4060321 dfp 7064795 dfp Escherichia coli O127:H6 str. E2348/69 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_002331349.1 4059101 D 574521 CDS YP_002331350.1 215488919 7065013 4060302..4060757 1 NC_011601.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 4060757 dut 7065013 dut Escherichia coli O127:H6 str. E2348/69 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_002331350.1 4060302 D 574521 CDS YP_002331351.1 215488920 7065074 4060864..4061460 1 NC_011601.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 4061460 slmA 7065074 slmA Escherichia coli O127:H6 str. E2348/69 nucleoid occlusion protein YP_002331351.1 4060864 D 574521 CDS YP_002331352.1 215488921 7062720 complement(4061504..4062463) 1 NC_011601.1 RNA-directed DNA polymerase 4062463 7062720 E2348C_3890 Escherichia coli O127:H6 str. E2348/69 RNA-directed DNA polymerase YP_002331352.1 4061504 R 574521 CDS YP_002331353.1 215488922 7061156 complement(4062760..4063401) 1 NC_011601.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 4063401 pyrE 7061156 pyrE Escherichia coli O127:H6 str. E2348/69 orotate phosphoribosyltransferase YP_002331353.1 4062760 R 574521 CDS YP_002331354.1 215488923 7063932 complement(4063467..4064183) 1 NC_011601.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 4064183 rph 7063932 rph Escherichia coli O127:H6 str. E2348/69 ribonuclease PH YP_002331354.1 4063467 R 574521 CDS YP_002331355.1 215488924 7061826 4064310..4065173 1 NC_011601.1 hypothetical protein 4065173 yicC 7061826 yicC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331355.1 4064310 D 574521 CDS YP_002331356.1 215488925 7061164 4065361..4066620 1 NC_011601.1 integrase 4066620 7061164 E2348C_3894 Escherichia coli O127:H6 str. E2348/69 integrase YP_002331356.1 4065361 D 574521 CDS YP_002331357.1 215488926 7062661 4067124..4067675 1 NC_011601.1 hypothetical protein 4067675 7062661 E2348C_3895 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331357.1 4067124 D 574521 CDS YP_002331358.1 215488927 7062662 4067765..4068034 1 NC_011601.1 hypothetical protein 4068034 7062662 E2348C_3896 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331358.1 4067765 D 574521 CDS YP_002331359.1 215488928 7062663 4068034..4068765 1 NC_011601.1 hypothetical protein 4068765 7062663 E2348C_3897 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331359.1 4068034 D 574521 CDS YP_002331360.1 215488929 7062664 complement(4068813..4070036) 1 NC_011601.1 DNA-bining transcriptional regulator 4070036 7062664 E2348C_3898 Escherichia coli O127:H6 str. E2348/69 DNA-bining transcriptional regulator YP_002331360.1 4068813 R 574521 CDS YP_002331361.1 215488930 7062665 complement(4070033..4070674) 1 NC_011601.1 hypothetical protein 4070674 7062665 E2348C_3899 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331361.1 4070033 R 574521 CDS YP_002331362.1 215488931 7062666 4071210..4071890 1 NC_011601.1 hypothetical protein 4071890 7062666 E2348C_3900 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331362.1 4071210 D 574521 CDS YP_002331363.1 215488932 7062667 4071993..4072205 1 NC_011601.1 hypothetical protein 4072205 7062667 E2348C_3901 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331363.1 4071993 D 574521 CDS YP_002331364.1 215488933 7062668 4072213..4072584 1 NC_011601.1 hypothetical protein 4072584 7062668 E2348C_3902 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331364.1 4072213 D 574521 CDS YP_002331365.1 215488934 7062669 4072589..4072789 1 NC_011601.1 hypothetical protein 4072789 7062669 E2348C_3903 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331365.1 4072589 D 574521 CDS YP_002331366.1 215488935 7062670 4072782..4072976 1 NC_011601.1 hypothetical protein 4072976 7062670 E2348C_3904 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331366.1 4072782 D 574521 CDS YP_002331367.1 215488936 7062671 4072969..4073157 1 NC_011601.1 hypothetical protein 4073157 7062671 E2348C_3905 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331367.1 4072969 D 574521 CDS YP_002331368.1 215488937 7062672 4073150..4073458 1 NC_011601.1 hypothetical protein 4073458 7062672 E2348C_3906 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331368.1 4073150 D 574521 CDS YP_002331369.1 215488938 7062673 4073458..4073679 1 NC_011601.1 hypothetical protein 4073679 7062673 E2348C_3907 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331369.1 4073458 D 574521 CDS YP_002331370.1 215488939 7062674 4073676..4076090 1 NC_011601.1 DNA primase 4076090 7062674 E2348C_3908 Escherichia coli O127:H6 str. E2348/69 DNA primase YP_002331370.1 4073676 D 574521 CDS YP_002331371.1 215488940 7062675 4076717..4077541 1 NC_011601.1 DNA-damage-inducible protein D 4077541 dinD 7062675 dinD Escherichia coli O127:H6 str. E2348/69 DNA-damage-inducible protein D YP_002331371.1 4076717 D 574521 CDS YP_002331372.1 215488941 7065029 4077833..4078450 1 NC_011601.1 hypothetical protein 4078450 yicG 7065029 yicG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331372.1 4077833 D 574521 CDS YP_002331373.1 215488942 7064788 complement(4078447..4080132) 1 NC_011601.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB 4080132 ligB 7064788 ligB Escherichia coli O127:H6 str. E2348/69 NAD-dependent DNA ligase LigB YP_002331373.1 4078447 R 574521 CDS YP_002331374.1 215488943 7061540 4080390..4081013 1 NC_011601.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 4081013 gmk 7061540 gmk Escherichia coli O127:H6 str. E2348/69 guanylate kinase YP_002331374.1 4080390 D 574521 CDS YP_002331375.1 215488944 7061731 4081068..4081343 1 NC_011601.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 4081343 rpoZ 7061731 rpoZ Escherichia coli O127:H6 str. E2348/69 DNA-directed RNA polymerase subunit omega YP_002331375.1 4081068 D 574521 CDS YP_002331376.1 215488945 7061871 4081362..4083470 1 NC_011601.1 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 4083470 spoT 7061871 spoT Escherichia coli O127:H6 str. E2348/69 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase YP_002331376.1 4081362 D 574521 CDS YP_002331377.1 215488946 7062749 4083477..4084166 1 NC_011601.1 specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 4084166 trmH 7062749 trmH Escherichia coli O127:H6 str. E2348/69 tRNA guanosine-2'-O-methyltransferase YP_002331377.1 4083477 D 574521 CDS YP_002331378.1 215488947 7062243 4084172..4086253 1 NC_011601.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 4086253 recG 7062243 recG Escherichia coli O127:H6 str. E2348/69 ATP-dependent DNA helicase RecG YP_002331378.1 4084172 D 574521 CDS YP_002331379.1 215488948 7063980 complement(4086287..4087492) 1 NC_011601.1 glutamate transporter 4087492 gltS 7063980 gltS Escherichia coli O127:H6 str. E2348/69 glutamate transporter YP_002331379.1 4086287 R 574521 CDS YP_002331380.1 215488949 7061712 4087772..4089163 1 NC_011601.1 transporter 4089163 yicE 7061712 yicE Escherichia coli O127:H6 str. E2348/69 transporter YP_002331380.1 4087772 D 574521 CDS YP_002331381.1 215488950 7064787 4089284..4090993 1 NC_011601.1 hypothetical protein 4090993 yicH 7064787 yicH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331381.1 4089284 D 574521 CDS YP_002331382.1 215488951 7064789 complement(4091037..4091717) 1 NC_011601.1 hypothetical protein 4091717 7064789 E2348C_3920 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331382.1 4091037 R 574521 CDS YP_002331383.1 215488952 7062676 complement(4091698..4092663) 1 NC_011601.1 hypothetical protein 4092663 7062676 E2348C_3921 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331383.1 4091698 R 574521 CDS YP_002331384.1 215488953 7062677 complement(4092678..4093538) 1 NC_011601.1 hypothetical protein 4093538 7062677 E2348C_3922 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331384.1 4092678 R 574521 CDS YP_002331385.1 215488954 7062678 complement(4093619..4094470) 1 NC_011601.1 fructose-bisphosphate aldolase, class-II family 4094470 7062678 E2348C_3923 Escherichia coli O127:H6 str. E2348/69 fructose-bisphosphate aldolase, class-II family YP_002331385.1 4093619 R 574521 CDS YP_002331386.1 215488955 7062679 complement(4094482..4095573) 1 NC_011601.1 fructose-specific PTS enzymes, IIC component 4095573 7062679 E2348C_3924 Escherichia coli O127:H6 str. E2348/69 fructose-specific PTS enzymes, IIC component YP_002331386.1 4094482 R 574521 CDS YP_002331387.1 215488956 7062680 complement(4095598..4095912) 1 NC_011601.1 fructose-specific PTS enzymes, IIB component 4095912 7062680 E2348C_3925 Escherichia coli O127:H6 str. E2348/69 fructose-specific PTS enzymes, IIB component YP_002331387.1 4095598 R 574521 CDS YP_002331388.1 215488957 7062681 complement(4095930..4096400) 1 NC_011601.1 fructose-specific PTS enzymes, IIA component 4096400 7062681 E2348C_3926 Escherichia coli O127:H6 str. E2348/69 fructose-specific PTS enzymes, IIA component YP_002331388.1 4095930 R 574521 CDS YP_002331389.1 215488958 7062682 complement(4096427..4097980) 1 NC_011601.1 transcriptional antiterminator 4097980 7062682 E2348C_3927 Escherichia coli O127:H6 str. E2348/69 transcriptional antiterminator YP_002331389.1 4096427 R 574521 CDS YP_002331390.1 215488959 7062683 complement(4098275..4100593) 1 NC_011601.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase 4100593 yicI 7062683 yicI Escherichia coli O127:H6 str. E2348/69 alpha-xylosidase YP_002331390.1 4098275 R 574521 CDS YP_002331391.1 215488960 7064790 complement(4100603..4101985) 1 NC_011601.1 may be involved in the transport of galactosides-pentoses-hexuronides; transporter 4101985 yicJ 7064790 yicJ Escherichia coli O127:H6 str. E2348/69 transporter YP_002331391.1 4100603 R 574521 CDS YP_002331392.1 215488961 7061130 complement(4103271..4103891) 1 NC_011601.1 LEE-encoded effector EspF 4103891 espF 7061130 espF Escherichia coli O127:H6 str. E2348/69 LEE-encoded effector EspF YP_002331392.1 4103271 R 574521 CDS YP_002331393.1 215488962 7063881 complement(4103976..4104254) 1 NC_011601.1 component of T3SS 4104254 7063881 E2348C_3931 Escherichia coli O127:H6 str. E2348/69 component of T3SS YP_002331393.1 4103976 R 574521 CDS YP_002331394.1 215488963 7062684 complement(4104260..4104481) 1 NC_011601.1 T3SS structure protein EscF 4104481 escF 7062684 escF Escherichia coli O127:H6 str. E2348/69 T3SS structure protein EscF YP_002331394.1 4104260 R 574521 CDS YP_002331395.1 215488964 7063869 complement(4104518..4104925) 1 NC_011601.1 chaperone CesD2 4104925 cesD2 7063869 cesD2 Escherichia coli O127:H6 str. E2348/69 chaperone CesD2 YP_002331395.1 4104518 R 574521 CDS YP_002331396.1 215488965 7064346 complement(4104932..4105897) 1 NC_011601.1 translocon EspB 4105897 espB 7064346 espB Escherichia coli O127:H6 str. E2348/69 translocon EspB YP_002331396.1 4104932 R 574521 CDS YP_002331397.1 215488966 7063878 complement(4105918..4107060) 1 NC_011601.1 translocon EspD 4107060 espD 7063878 espD Escherichia coli O127:H6 str. E2348/69 translocon EspD YP_002331397.1 4105918 R 574521 CDS YP_002331398.1 215488967 7063880 complement(4107073..4107651) 1 NC_011601.1 translocon EspA 4107651 espA 7063880 espA Escherichia coli O127:H6 str. E2348/69 translocon EspA YP_002331398.1 4107073 R 574521 CDS YP_002331399.1 215488968 7063877 complement(4107708..4108763) 1 NC_011601.1 secretion switching protein SpeL 4108763 speL 7063877 speL Escherichia coli O127:H6 str. E2348/69 secretion switching protein SpeL YP_002331399.1 4107708 R 574521 CDS YP_002331400.1 215488969 7062747 4108906..4110126 1 NC_011601.1 T3SS structure protein EscD 4110126 escD 7062747 escD Escherichia coli O127:H6 str. E2348/69 T3SS structure protein EscD YP_002331400.1 4108906 D 574521 CDS YP_002331401.1 215488970 7063868 complement(4110343..4113162) 1 NC_011601.1 intimin EaeA 4113162 eaeA 7063868 eaeA Escherichia coli O127:H6 str. E2348/69 intimin EaeA YP_002331401.1 4110343 R 574521 CDS YP_002331402.1 215488971 7065077 complement(4113222..4113692) 1 NC_011601.1 chaperone CesT 4113692 cesT 7065077 cesT Escherichia coli O127:H6 str. E2348/69 chaperone CesT YP_002331402.1 4113222 R 574521 CDS YP_002331403.1 215488972 7064348 complement(4113830..4115482) 1 NC_011601.1 translocated intimin receptor Tir 4115482 tir 7064348 tir Escherichia coli O127:H6 str. E2348/69 translocated intimin receptor Tir YP_002331403.1 4113830 R 574521 CDS YP_002331404.1 215488973 7061805 complement(4115809..4116420) 1 NC_011601.1 LEE-encoded effector Map 4116420 map 7061805 map Escherichia coli O127:H6 str. E2348/69 LEE-encoded effector Map YP_002331404.1 4115809 R 574521 CDS YP_002331405.1 215488974 7065290 4116695..4117057 1 NC_011601.1 chaperone CesF 4117057 cesF 7065290 cesF Escherichia coli O127:H6 str. E2348/69 chaperone CesF YP_002331405.1 4116695 D 574521 CDS YP_002331406.1 215488975 7064347 complement(4117259..4117765) 1 NC_011601.1 LEE-encoded effector EspH 4117765 espH 7064347 espH Escherichia coli O127:H6 str. E2348/69 LEE-encoded effector EspH YP_002331406.1 4117259 R 574521 CDS YP_002331407.1 215488976 7063883 complement(4117796..4118713) 1 NC_011601.1 T3SS structure protein SepQ 4118713 sepQ 7063883 sepQ Escherichia coli O127:H6 str. E2348/69 T3SS structure protein SepQ YP_002331407.1 4117796 R 574521 CDS YP_002331408.1 215488977 7065364 complement(4118676..4119092) 1 NC_011601.1 hypothetical protein 4119092 7065364 E2348C_3946 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331408.1 4118676 R 574521 CDS YP_002331409.1 215488978 7062685 complement(4119085..4119462) 1 NC_011601.1 hypothetical protein 4119462 7062685 E2348C_3947 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331409.1 4119085 R 574521 CDS YP_002331410.1 215488979 7062686 complement(4119465..4120805) 1 NC_011601.1 translocator EscN 4120805 escN 7062686 escN Escherichia coli O127:H6 str. E2348/69 translocator EscN YP_002331410.1 4119465 R 574521 CDS YP_002331411.1 215488980 7063871 complement(4120789..4122816) 1 NC_011601.1 translocator EscV 4122816 escV 7063871 escV Escherichia coli O127:H6 str. E2348/69 translocator EscV YP_002331411.1 4120789 R 574521 CDS YP_002331412.1 215488981 7063876 complement(4122813..4123166) 1 NC_011601.1 regulator Mpc 4123166 mpc 7063876 mpc Escherichia coli O127:H6 str. E2348/69 regulator Mpc YP_002331412.1 4122813 R 574521 CDS YP_002331413.1 215488982 7063824 4123351..4123647 1 NC_011601.1 LEE-encoded effector EspZ 4123647 espZ 7063824 espZ Escherichia coli O127:H6 str. E2348/69 LEE-encoded effector EspZ YP_002331413.1 4123351 D 574521 CDS YP_002331414.1 215488983 7063884 4123677..4124105 1 NC_011601.1 chaperone of T3SS Rorf8 4124105 rorf8 7063884 rorf8 Escherichia coli O127:H6 str. E2348/69 chaperone of T3SS Rorf8 YP_002331414.1 4123677 D 574521 CDS YP_002331415.1 215488984 7061824 4124108..4124680 1 NC_011601.1 T3SS structure protein EscJ 4124680 escJ 7061824 escJ Escherichia coli O127:H6 str. E2348/69 T3SS structure protein EscJ YP_002331415.1 4124108 D 574521 CDS YP_002331416.1 215488985 7063870 4124686..4125141 1 NC_011601.1 secretion switching protein SepD 4125141 sepD 7063870 sepD Escherichia coli O127:H6 str. E2348/69 secretion switching protein SepD YP_002331416.1 4124686 D 574521 CDS YP_002331417.1 215488986 7065363 4125141..4126679 1 NC_011601.1 T3SS structure protein EscC 4126679 escC 7065363 escC Escherichia coli O127:H6 str. E2348/69 T3SS structure protein EscC YP_002331417.1 4125141 D 574521 CDS YP_002331418.1 215488987 7063867 4126693..4127148 1 NC_011601.1 chaperone CesD 4127148 cesD 7063867 cesD Escherichia coli O127:H6 str. E2348/69 chaperone CesD YP_002331418.1 4126693 D 574521 CDS YP_002331419.1 215488988 7064345 complement(4127532..4127945) 1 NC_011601.1 positive regulator GrlA 4127945 grlA 7064345 grlA Escherichia coli O127:H6 str. E2348/69 positive regulator GrlA YP_002331419.1 4127532 R 574521 CDS YP_002331420.1 215488989 7064241 complement(4128001..4128372) 1 NC_011601.1 negative regulator GrlR 4128372 grlR 7064241 grlR Escherichia coli O127:H6 str. E2348/69 negative regulator GrlR YP_002331420.1 4128001 R 574521 CDS YP_002331421.1 215488990 7064242 4128568..4129026 1 NC_011601.1 hypothetical protein 4129026 7064242 E2348C_3959 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331421.1 4128568 D 574521 CDS YP_002331422.1 215488991 7062687 complement(4129023..4130060) 1 NC_011601.1 member of a type III secretion system which is part of a pathogenicity island in Salmonella, Yersinia and pathogenic Escherichia coli; secretion system apparatus protein SsaU 4130060 escU 7062687 escU Escherichia coli O127:H6 str. E2348/69 secretion system apparatus protein SsaU YP_002331422.1 4129023 R 574521 CDS YP_002331423.1 215488992 7063875 complement(4130053..4130829) 1 NC_011601.1 T3SS structure protein EscT 4130829 escT 7063875 escT Escherichia coli O127:H6 str. E2348/69 T3SS structure protein EscT YP_002331423.1 4130053 R 574521 CDS YP_002331424.1 215488993 7063874 complement(4130829..4131098) 1 NC_011601.1 T3SS structure protein EscS 4131098 escS 7063874 escS Escherichia coli O127:H6 str. E2348/69 T3SS structure protein EscS YP_002331424.1 4130829 R 574521 CDS YP_002331425.1 215488994 7063873 complement(4131098..4131751) 1 NC_011601.1 part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response; type III secretion system protein 4131751 escR 7063873 escR Escherichia coli O127:H6 str. E2348/69 type III secretion system protein YP_002331425.1 4131098 R 574521 CDS YP_002331426.1 215488995 7063872 complement(4131756..4132451) 1 NC_011601.1 component of T3SS 4132451 7063872 E2348C_3964 Escherichia coli O127:H6 str. E2348/69 component of T3SS YP_002331426.1 4131756 R 574521 CDS YP_002331427.1 215488996 7062688 complement(4132396..4132995) 1 NC_011601.1 component of T3SS 4132995 7062688 E2348C_3965 Escherichia coli O127:H6 str. E2348/69 component of T3SS YP_002331427.1 4132396 R 574521 CDS YP_002331428.1 215488997 7062689 complement(4132992..4133315) 1 NC_011601.1 component of T3SS 4133315 7062689 E2348C_3966 Escherichia coli O127:H6 str. E2348/69 component of T3SS YP_002331428.1 4132992 R 574521 CDS YP_002331429.1 215488998 7062690 complement(4133319..4133537) 1 NC_011601.1 component of T3SS 4133537 7062690 E2348C_3967 Escherichia coli O127:H6 str. E2348/69 component of T3SS YP_002331429.1 4133319 R 574521 CDS YP_002331430.1 215488999 7062691 complement(4133552..4133941) 1 NC_011601.1 transcriptional regulator Ler 4133941 ler 7062691 ler Escherichia coli O127:H6 str. E2348/69 transcriptional regulator Ler YP_002331430.1 4133552 R 574521 CDS YP_002331431.1 215489000 7061520 complement(4134445..4134624) 1 NC_011601.1 hypothetical protein 4134624 7061520 E2348C_3969 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331431.1 4134445 R 574521 CDS YP_002331432.1 215489001 7062692 4135193..4136389 1 NC_011601.1 LEE-encoded effector EspG 4136389 espG 7062692 espG Escherichia coli O127:H6 str. E2348/69 LEE-encoded effector EspG YP_002331432.1 4135193 D 574521 CDS YP_002331433.1 215489002 7063882 4136517..4137335 1 NC_011601.1 hypothetical protein 4137335 7063882 E2348C_3971 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331433.1 4136517 D 574521 CDS YP_002331434.1 215489003 7062693 complement(4137729..4137890) 1 NC_011601.1 hypothetical protein 4137890 7062693 E2348C_3972 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331434.1 4137729 R 574521 CDS YP_002331435.1 215489004 7062694 complement(4138106..4138312) 1 NC_011601.1 hypothetical protein 4138312 7062694 E2348C_3973 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331435.1 4138106 R 574521 CDS YP_002331436.1 215489005 7062695 4138354..4139277 1 NC_011601.1 hypothetical protein 4139277 yicL 7062695 yicL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331436.1 4138354 D 574521 CDS YP_002331437.1 215489006 7064792 complement(4139281..4140099) 1 NC_011601.1 hypothetical protein 4140099 nlpA 7064792 nlpA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331437.1 4139281 R 574521 CDS YP_002331438.1 215489007 7065400 4140255..4140614 1 NC_011601.1 hypothetical protein 4140614 7065400 E2348C_3976 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331438.1 4140255 D 574521 CDS YP_002331439.1 215489008 7062696 complement(4140655..4141845) 1 NC_011601.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter 4141845 nepI 7062696 nepI Escherichia coli O127:H6 str. E2348/69 ribonucleoside transporter YP_002331439.1 4140655 R 574521 CDS YP_002331440.1 215489009 7065380 complement(4142056..4142508) 1 NC_011601.1 hypothetical protein 4142508 yicN 7065380 yicN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331440.1 4142056 R 574521 CDS YP_002331441.1 215489010 7064793 complement(4142561..4143895) 1 NC_011601.1 xanthine/uracil permase 4143895 yicO 7064793 yicO Escherichia coli O127:H6 str. E2348/69 xanthine/uracil permase YP_002331441.1 4142561 R 574521 CDS YP_002331442.1 215489011 7062405 complement(4145885..4147276) 1 NC_011601.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 4147276 uhpT 7062405 uhpT Escherichia coli O127:H6 str. E2348/69 sugar phosphate antiporter YP_002331442.1 4145885 R 574521 CDS YP_002331443.1 215489012 7062311 complement(4147532..4148851) 1 NC_011601.1 membrane protein regulates uhpT expression; regulatory protein UhpC 4148851 uhpC 7062311 uhpC Escherichia coli O127:H6 str. E2348/69 regulatory protein UhpC YP_002331443.1 4147532 R 574521 CDS YP_002331444.1 215489013 7062310 complement(4148861..4150363) 1 NC_011601.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB 4150363 uhpB 7062310 uhpB Escherichia coli O127:H6 str. E2348/69 sensory histidine kinase UhpB YP_002331444.1 4148861 R 574521 CDS YP_002331445.1 215489014 7062309 complement(4150363..4150953) 1 NC_011601.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA 4150953 uhpA 7062309 uhpA Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator UhpA YP_002331445.1 4150363 R 574521 CDS YP_002331446.1 215489015 7062308 complement(4151026..4151316) 1 NC_011601.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit 4151316 ilvN 7062308 ilvN Escherichia coli O127:H6 str. E2348/69 acetolactate synthase 1 regulatory subunit YP_002331446.1 4151026 R 574521 CDS YP_002331447.1 215489016 7063538 complement(4151320..4153008) 1 NC_011601.1 acetolactate synthase catalytic subunit 4153008 ilvB 7063538 ilvB Escherichia coli O127:H6 str. E2348/69 acetolactate synthase catalytic subunit YP_002331447.1 4151320 R 574521 CDS YP_002331448.1 215489017 7063529 complement(4153114..4153212) 1 NC_011601.1 ilvB operon leader peptide 4153212 ivbL 7063529 ivbL Escherichia coli O127:H6 str. E2348/69 ilvB operon leader peptide YP_002331448.1 4153114 R 574521 CDS YP_002331449.1 215489018 7063561 4153613..4154797 1 NC_011601.1 multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 4154797 emrD 7063561 emrD Escherichia coli O127:H6 str. E2348/69 multidrug resistance protein D YP_002331449.1 4153613 D 574521 CDS YP_002331450.1 215489019 7063846 complement(4154805..4155302) 1 NC_011601.1 DNA-binding transcriptional regulator 4155302 yidF 7063846 yidF Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002331450.1 4154805 R 574521 CDS YP_002331451.1 215489020 7064799 complement(4155299..4155661) 1 NC_011601.1 hypothetical protein 4155661 yidG 7064799 yidG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331451.1 4155299 R 574521 CDS YP_002331452.1 215489021 7064800 complement(4155651..4155998) 1 NC_011601.1 hypothetical protein 4155998 yidH 7064800 yidH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331452.1 4155651 R 574521 CDS YP_002331453.1 215489022 7064801 complement(4156058..4157551) 1 NC_011601.1 sulfatase/phosphatase 4157551 yidJ 7064801 yidJ Escherichia coli O127:H6 str. E2348/69 sulfatase/phosphatase YP_002331453.1 4156058 R 574521 CDS YP_002331454.1 215489023 7064802 complement(4157548..4159263) 1 NC_011601.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; symporter YidK 4159263 yidK 7064802 yidK Escherichia coli O127:H6 str. E2348/69 symporter YidK YP_002331454.1 4157548 R 574521 CDS YP_002331455.1 215489024 7064803 4159430..4160296 1 NC_011601.1 DNA-binding transcriptional regulator 4160296 yidL 7064803 yidL Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002331455.1 4159430 D 574521 CDS YP_002331456.1 215489025 7064804 complement(4160386..4162047) 1 NC_011601.1 hypothetical protein 4162047 yidP 7064804 yidP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331456.1 4160386 R 574521 CDS YP_002331457.1 215489026 7064805 complement(4162243..4162671) 1 NC_011601.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB 4162671 ibpB 7064805 ibpB Escherichia coli O127:H6 str. E2348/69 heat shock chaperone IbpB YP_002331457.1 4162243 R 574521 CDS YP_002331458.1 215489027 7063516 complement(4162783..4163196) 1 NC_011601.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA 4163196 ibpA 7063516 ibpA Escherichia coli O127:H6 str. E2348/69 heat shock protein IbpA YP_002331458.1 4162783 R 574521 CDS YP_002331459.1 215489028 7063515 4163501..4163833 1 NC_011601.1 hypothetical protein 4163833 yidQ 7063515 yidQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331459.1 4163501 D 574521 CDS YP_002331460.1 215489029 7064806 complement(4163835..4165049) 1 NC_011601.1 hypothetical protein 4165049 yidR 7064806 yidR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331460.1 4163835 R 574521 CDS YP_002331461.1 215489030 7064807 4165150..4166250 1 NC_011601.1 FAD/NAD(P)-binding domain; oxidoreductase 4166250 cbrA 7064807 cbrA Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002331461.1 4165150 D 574521 CDS YP_002331462.1 215489031 7064329 complement(4166211..4167503) 1 NC_011601.1 D-galactonate transporter 4167503 dgoT 7064329 dgoT Escherichia coli O127:H6 str. E2348/69 D-galactonate transporter YP_002331462.1 4166211 R 574521 CDS YP_002331463.1 215489032 7061131 complement(4168005..4169378) 1 NC_011601.1 transposase of ISEc13 4169378 7061131 E2348C_4003 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002331463.1 4168005 R 574521 CDS YP_002331464.1 215489033 7062697 complement(4170326..4170943) 1 NC_011601.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 4170943 dgoA 7062697 dgoA Escherichia coli O127:H6 str. E2348/69 2-dehydro-3-deoxy-6-phosphogalactonate aldolase YP_002331464.1 4170326 R 574521 CDS YP_002331465.1 215489034 7065015 complement(4170927..4171805) 1 NC_011601.1 2-oxo-3-deoxygalactonate kinase 4171805 dgoK 7065015 dgoK Escherichia coli O127:H6 str. E2348/69 2-oxo-3-deoxygalactonate kinase YP_002331465.1 4170927 R 574521 CDS YP_002331466.1 215489035 7065016 complement(4171802..4172491) 1 NC_011601.1 DNA-binding transcriptional regulator 4172491 dgoR 7065016 dgoR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002331466.1 4171802 R 574521 CDS YP_002331467.1 215489036 7065017 4172770..4173426 1 NC_011601.1 hypothetical protein 4173426 yidX 7065017 yidX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331467.1 4172770 D 574521 CDS YP_002331468.1 215489037 7064808 complement(4173470..4174282) 1 NC_011601.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase 4174282 yidA 7064808 yidA Escherichia coli O127:H6 str. E2348/69 sugar phosphatase YP_002331468.1 4173470 R 574521 CDS YP_002331469.1 215489038 7064796 complement(4174397..4174795) 1 NC_011601.1 hypothetical protein 4174795 yidB 7064796 yidB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331469.1 4174397 R 574521 CDS YP_002331470.1 215489039 7064797 complement(4175029..4177443) 1 NC_011601.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 4177443 gyrB 7064797 gyrB Escherichia coli O127:H6 str. E2348/69 DNA gyrase subunit B YP_002331470.1 4175029 R 574521 CDS YP_002331471.1 215489040 7064279 complement(4177472..4178545) 1 NC_011601.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4178545 recF 7064279 recF Escherichia coli O127:H6 str. E2348/69 recombination protein F YP_002331471.1 4177472 R 574521 CDS YP_002331472.1 215489041 7063979 complement(4178545..4179645) 1 NC_011601.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 4179645 dnaN 7063979 dnaN Escherichia coli O127:H6 str. E2348/69 DNA polymerase III subunit beta YP_002331472.1 4178545 R 574521 CDS YP_002331473.1 215489042 7065051 complement(4179650..4181053) 1 NC_011601.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 4181053 dnaA 7065051 dnaA Escherichia coli O127:H6 str. E2348/69 chromosomal replication initiation protein YP_002331473.1 4179650 R 574521 CDS YP_002331474.1 215489043 7065044 4181660..4181800 1 NC_011601.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4181800 rpmH 7065044 rpmH Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L34 YP_002331474.1 4181660 D 574521 CDS YP_002331475.1 215489044 7061860 4181817..4182176 1 NC_011601.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4182176 rnpA 7061860 rnpA Escherichia coli O127:H6 str. E2348/69 ribonuclease P YP_002331475.1 4181817 D 574521 CDS YP_002331476.1 215489045 7060856 4182400..4184046 1 NC_011601.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 4184046 yidC 7060856 yidC Escherichia coli O127:H6 str. E2348/69 inner membrane protein translocase component YidC YP_002331476.1 4182400 D 574521 CDS YP_002331477.1 215489046 7064798 4184152..4185516 1 NC_011601.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 4185516 trmE 7064798 trmE Escherichia coli O127:H6 str. E2348/69 tRNA modification GTPase TrmE YP_002331477.1 4184152 D 574521 CDS YP_002331478.1 215489047 7063801 4185758..4185832 1 NC_011601.1 tryptophanase leader peptide 4185832 tanC 7063801 tanC Escherichia coli O127:H6 str. E2348/69 tryptophanase leader peptide YP_002331478.1 4185758 D 574521 CDS YP_002331479.1 215489048 7061752 4186053..4187468 1 NC_011601.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 4187468 tnaA 7061752 tnaA Escherichia coli O127:H6 str. E2348/69 tryptophanase YP_002331479.1 4186053 D 574521 CDS YP_002331480.1 215489049 7061810 4187604..4188806 1 NC_011601.1 tryptophan transporter of low affinity; tryptophan permease TnaB 4188806 tnaB 7061810 tnaB Escherichia coli O127:H6 str. E2348/69 tryptophan permease TnaB YP_002331480.1 4187604 D 574521 CDS YP_002331481.1 215489050 7061811 4188938..4190113 1 NC_011601.1 Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 4190113 mdtL 7061811 mdtL Escherichia coli O127:H6 str. E2348/69 multidrug efflux system protein MdtL YP_002331481.1 4188938 D 574521 CDS YP_002331482.1 215489051 7065317 4190088..4191047 1 NC_011601.1 Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 4191047 yidZ 7065317 yidZ Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YidZ YP_002331482.1 4190088 D 574521 CDS YP_002331483.1 215489052 7064809 4191192..4191953 1 NC_011601.1 phosphopantetheinyl transferase 4191953 yieE 7064809 yieE Escherichia coli O127:H6 str. E2348/69 phosphopantetheinyl transferase YP_002331483.1 4191192 D 574521 CDS YP_002331484.1 215489053 7064810 4191975..4192541 1 NC_011601.1 chromate reductase, Class I, flavoprotein 4192541 yieF 7064810 yieF Escherichia coli O127:H6 str. E2348/69 chromate reductase, Class I, flavoprotein YP_002331484.1 4191975 D 574521 CDS YP_002331485.1 215489054 7064811 complement(4192595..4193932) 1 NC_011601.1 hypothetical protein 4193932 yieG 7064811 yieG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331485.1 4192595 R 574521 CDS YP_002331486.1 215489055 7064812 4194099..4194764 1 NC_011601.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 4194764 yieH 7064812 yieH Escherichia coli O127:H6 str. E2348/69 6-phosphogluconate phosphatase YP_002331486.1 4194099 D 574521 CDS YP_002331487.1 215489056 7064813 4194831..4195304 1 NC_011601.1 might be involved in hypersensitivity to nitrofurzone; hypothetical protein 4195304 cbrB 7064813 cbrB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331487.1 4194831 D 574521 CDS YP_002331488.1 215489057 7064814 complement(4196123..4197292) 1 NC_011601.1 xylanase 4197292 yieL 7064814 yieL Escherichia coli O127:H6 str. E2348/69 xylanase YP_002331488.1 4196123 R 574521 CDS YP_002331489.1 215489058 7064815 complement(4197319..4198935) 1 NC_011601.1 carbohydrate-specific outer membrane porin, cryptic 4198935 bglH 7064815 bglH Escherichia coli O127:H6 str. E2348/69 carbohydrate-specific outer membrane porin, cryptic YP_002331489.1 4197319 R 574521 CDS YP_002331490.1 215489059 7062516 complement(4199021..4200415) 1 NC_011601.1 cryptic phospho-beta-glucosidase B 4200415 bglB 7062516 bglB Escherichia coli O127:H6 str. E2348/69 cryptic phospho-beta-glucosidase B YP_002331490.1 4199021 R 574521 CDS YP_002331491.1 215489060 7062513 complement(4200434..4202308) 1 NC_011601.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system beta-glucoside-specific transporter subunit IIABC 4202308 bglF 7062513 bglF Escherichia coli O127:H6 str. E2348/69 PTS system beta-glucoside-specific transporter subunit IIABC YP_002331491.1 4200434 R 574521 CDS YP_002331492.1 215489061 7062514 complement(4202441..4203277) 1 NC_011601.1 positive regulator of the beta-glucoside operon; transcriptional antiterminator; transcriptional antiterminator BglG 4203277 bglG 7062514 bglG Escherichia coli O127:H6 str. E2348/69 transcriptional antiterminator BglG YP_002331492.1 4202441 R 574521 CDS YP_002331493.1 215489062 7062515 complement(4203563..4204288) 1 NC_011601.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 4204288 phoU 7062515 phoU Escherichia coli O127:H6 str. E2348/69 transcriptional regulator PhoU YP_002331493.1 4203563 R 574521 CDS YP_002331494.1 215489063 7060749 complement(4204303..4205076) 1 NC_011601.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 4205076 pstB 7060749 pstB Escherichia coli O127:H6 str. E2348/69 phosphate transporter ATP-binding protein YP_002331494.1 4204303 R 574521 CDS YP_002331495.1 215489064 7061330 complement(4205167..4206057) 1 NC_011601.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA 4206057 pstA 7061330 pstA Escherichia coli O127:H6 str. E2348/69 phosphate transporter permease subunit PtsA YP_002331495.1 4205167 R 574521 CDS YP_002331496.1 215489065 7061329 complement(4206057..4207016) 1 NC_011601.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC 4207016 pstC 7061329 pstC Escherichia coli O127:H6 str. E2348/69 phosphate transporter permease subunit PstC YP_002331496.1 4206057 R 574521 CDS YP_002331497.1 215489066 7061331 complement(4207103..4208143) 1 NC_011601.1 phosphate ABC transporter substrate-binding protein 4208143 pstS 7061331 pstS Escherichia coli O127:H6 str. E2348/69 phosphate ABC transporter substrate-binding protein YP_002331497.1 4207103 R 574521 CDS YP_002331498.1 215489067 7061332 complement(4208457..4210286) 1 NC_011601.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 4210286 glmS 7061332 glmS Escherichia coli O127:H6 str. E2348/69 glucosamine--fructose-6-phosphate aminotransferase YP_002331498.1 4208457 R 574521 CDS YP_002331499.1 215489068 7061674 complement(4210448..4211818) 1 NC_011601.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 4211818 glmU 7061674 glmU Escherichia coli O127:H6 str. E2348/69 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_002331499.1 4210448 R 574521 CDS YP_002331500.1 215489069 7061675 complement(4212172..4212591) 1 NC_011601.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 4212591 atpC 7061675 atpC Escherichia coli O127:H6 str. E2348/69 ATP synthase F0F1 subunit epsilon YP_002331500.1 4212172 R 574521 CDS YP_002331501.1 215489070 7062481 complement(4212612..4213994) 1 NC_011601.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 4213994 atpD 7062481 atpD Escherichia coli O127:H6 str. E2348/69 ATP synthase F0F1 subunit beta YP_002331501.1 4212612 R 574521 CDS YP_002331502.1 215489071 7062482 complement(4214021..4214884) 1 NC_011601.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 4214884 atpG 7062482 atpG Escherichia coli O127:H6 str. E2348/69 ATP synthase F0F1 subunit gamma YP_002331502.1 4214021 R 574521 CDS YP_002331503.1 215489072 7062485 complement(4214935..4216476) 1 NC_011601.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 4216476 atpA 7062485 atpA Escherichia coli O127:H6 str. E2348/69 ATP synthase F0F1 subunit alpha YP_002331503.1 4214935 R 574521 CDS YP_002331504.1 215489073 7062479 complement(4216489..4217022) 1 NC_011601.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 4217022 atpH 7062479 atpH Escherichia coli O127:H6 str. E2348/69 ATP synthase F0F1 subunit delta YP_002331504.1 4216489 R 574521 CDS YP_002331505.1 215489074 7062486 complement(4217037..4217507) 1 NC_011601.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 4217507 atpF 7062486 atpF Escherichia coli O127:H6 str. E2348/69 ATP synthase F0F1 subunit B YP_002331505.1 4217037 R 574521 CDS YP_002331506.1 215489075 7062484 complement(4217569..4217808) 1 NC_011601.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 4217808 atpE 7062484 atpE Escherichia coli O127:H6 str. E2348/69 ATP synthase F0F1 subunit C YP_002331506.1 4217569 R 574521 CDS YP_002331507.1 215489076 7062483 complement(4217855..4218670) 1 NC_011601.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 4218670 atpB 7062483 atpB Escherichia coli O127:H6 str. E2348/69 ATP synthase F0F1 subunit A YP_002331507.1 4217855 R 574521 CDS YP_002331508.1 215489077 7062480 complement(4218679..4219059) 1 NC_011601.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 4219059 atpI 7062480 atpI Escherichia coli O127:H6 str. E2348/69 F0F1 ATP synthase subunit I YP_002331508.1 4218679 R 574521 CDS YP_002331509.1 215489078 7062487 complement(4219676..4220299) 1 NC_011601.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 4220299 gidB 7062487 gidB Escherichia coli O127:H6 str. E2348/69 16S rRNA methyltransferase GidB YP_002331509.1 4219676 R 574521 CDS YP_002331510.1 215489079 7061656 complement(4220363..4222252) 1 NC_011601.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 4222252 mnmG 7061656 mnmG Escherichia coli O127:H6 str. E2348/69 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_002331510.1 4220363 R 574521 CDS YP_002331511.1 215489080 7063802 complement(4222631..4223074) 1 NC_011601.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 4223074 mioC 7063802 mioC Escherichia coli O127:H6 str. E2348/69 flavodoxin YP_002331511.1 4222631 R 574521 CDS YP_002331512.1 215489081 7063791 complement(4223164..4223622) 1 NC_011601.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 4223622 asnC 7063791 asnC Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator AsnC YP_002331512.1 4223164 R 574521 CDS YP_002331513.1 215489082 7061413 4223774..4224766 1 NC_011601.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4224766 asnA 7061413 asnA Escherichia coli O127:H6 str. E2348/69 asparagine synthetase AsnA YP_002331513.1 4223774 D 574521 CDS YP_002331514.1 215489083 7061411 complement(4224771..4226222) 1 NC_011601.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 4226222 yieM 7061411 yieM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331514.1 4224771 R 574521 CDS YP_002331515.1 215489084 7062360 complement(4226216..4227712) 1 NC_011601.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA 4227712 ravA 7062360 ravA Escherichia coli O127:H6 str. E2348/69 regulatory ATPase RavA YP_002331515.1 4226216 R 574521 CDS YP_002331516.1 215489085 7063950 4227935..4229803 1 NC_011601.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4229803 trkD 7063950 trkD Escherichia coli O127:H6 str. E2348/69 potassium transport protein Kup YP_002331516.1 4227935 D 574521 CDS YP_002331517.1 215489086 7061507 4229970..4230389 1 NC_011601.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4230389 rbsD 7061507 rbsD Escherichia coli O127:H6 str. E2348/69 D-ribose pyranase YP_002331517.1 4229970 D 574521 CDS YP_002331518.1 215489087 7063957 4230397..4231902 1 NC_011601.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP-binding protein 4231902 rbsA 7063957 rbsA Escherichia coli O127:H6 str. E2348/69 D-ribose transporter ATP-binding protein YP_002331518.1 4230397 D 574521 CDS YP_002331519.1 215489088 7063954 4231907..4232872 1 NC_011601.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4232872 rbsC 7063954 rbsC Escherichia coli O127:H6 str. E2348/69 ribose ABC transporter permease YP_002331519.1 4231907 D 574521 CDS YP_002331520.1 215489089 7063956 4232897..4233787 1 NC_011601.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4233787 rbsB 7063956 rbsB Escherichia coli O127:H6 str. E2348/69 D-ribose transporter subunit RbsB YP_002331520.1 4232897 D 574521 CDS YP_002331521.1 215489090 7063955 4233913..4234842 1 NC_011601.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4234842 rbsK 7063955 rbsK Escherichia coli O127:H6 str. E2348/69 ribokinase YP_002331521.1 4233913 D 574521 CDS YP_002331522.1 215489091 7063958 4234846..4235838 1 NC_011601.1 DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4235838 rbsR 7063958 rbsR Escherichia coli O127:H6 str. E2348/69 transcriptional repressor RbsR YP_002331522.1 4234846 D 574521 CDS YP_002331523.1 215489092 7063959 complement(4235804..4237231) 1 NC_011601.1 multidrug or homocysteine efflux system protein HsrA 4237231 hsrA 7063959 hsrA Escherichia coli O127:H6 str. E2348/69 multidrug or homocysteine efflux system protein HsrA YP_002331523.1 4235804 R 574521 CDS YP_002331524.1 215489093 7062188 complement(4237254..4237946) 1 NC_011601.1 transcriptional regulator 4237946 yieP 7062188 yieP Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002331524.1 4237254 R 574521 CDS YP_002331525.1 215489094 7062262 complement(4243750..4244589) 1 NC_011601.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 4244589 hdfR 7062262 hdfR Escherichia coli O127:H6 str. E2348/69 transcriptional regulator HdfR YP_002331525.1 4243750 R 574521 CDS YP_002331526.1 215489095 7064288 4244708..4245046 1 NC_011601.1 hypothetical protein 4245046 yifE 7064288 yifE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331526.1 4244708 D 574521 CDS YP_002331527.1 215489096 7064818 complement(4245071..4246591) 1 NC_011601.1 among the AAA+ ATPases, the YifB protease belongs to the Helix 2 insert clade; unknown function; ATP-dependent protease 4246591 yifB 7064818 yifB Escherichia coli O127:H6 str. E2348/69 ATP-dependent protease YP_002331527.1 4245071 R 574521 CDS YP_002331528.1 215489097 7064817 4246944..4247042 1 NC_011601.1 ilvG operon leader peptide 4247042 ilvL 7064817 ilvL Escherichia coli O127:H6 str. E2348/69 ilvG operon leader peptide YP_002331528.1 4246944 D 574521 CDS YP_002331529.1 215489098 7063536 4247182..4248828 1 NC_011601.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4248828 ilvG 7063536 ilvG Escherichia coli O127:H6 str. E2348/69 acetolactate synthase 2 catalytic subunit YP_002331529.1 4247182 D 574521 CDS YP_002331530.1 215489099 7063533 4248825..4249088 1 NC_011601.1 acetolactate synthase 2 regulatory subunit 4249088 ilvM 7063533 ilvM Escherichia coli O127:H6 str. E2348/69 acetolactate synthase 2 regulatory subunit YP_002331530.1 4248825 D 574521 CDS YP_002331531.1 215489100 7063537 4249108..4250037 1 NC_011601.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4250037 ilvE 7063537 ilvE Escherichia coli O127:H6 str. E2348/69 branched-chain amino acid aminotransferase YP_002331531.1 4249108 D 574521 CDS YP_002331532.1 215489101 7063532 4250102..4251952 1 NC_011601.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4251952 ilvD 7063532 ilvD Escherichia coli O127:H6 str. E2348/69 dihydroxy-acid dehydratase YP_002331532.1 4250102 D 574521 CDS YP_002331533.1 215489102 7063531 4251955..4253499 1 NC_011601.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4253499 ilvA 7063531 ilvA Escherichia coli O127:H6 str. E2348/69 threonine dehydratase YP_002331533.1 4251955 D 574521 CDS YP_002331534.1 215489103 7063528 complement(4253496..4254386) 1 NC_011601.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 4254386 ilvY 7063528 ilvY Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator IlvY YP_002331534.1 4253496 R 574521 CDS YP_002331535.1 215489104 7063539 4254536..4256011 1 NC_011601.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4256011 ilvC 7063539 ilvC Escherichia coli O127:H6 str. E2348/69 ketol-acid reductoisomerase YP_002331535.1 4254536 D 574521 CDS YP_002331536.1 215489105 7063530 complement(4256057..4256338) 1 NC_011601.1 peptidyl-prolyl cis-trans isomerase C 4256338 ppiC 7063530 ppiC Escherichia coli O127:H6 str. E2348/69 peptidyl-prolyl cis-trans isomerase C YP_002331536.1 4256057 R 574521 CDS YP_002331537.1 215489106 7061272 4256425..4258446 1 NC_011601.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4258446 rep 7061272 rep Escherichia coli O127:H6 str. E2348/69 ATP-dependent DNA helicase Rep YP_002331537.1 4256425 D 574521 CDS YP_002331538.1 215489107 7060699 complement(4258493..4259977) 1 NC_011601.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 4259977 gpp 7060699 gpp Escherichia coli O127:H6 str. E2348/69 guanosine pentaphosphate phosphohydrolase YP_002331538.1 4258493 R 574521 CDS YP_002331539.1 215489108 7064236 complement(4260113..4261378) 1 NC_011601.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 4261378 rhlB 7064236 rhlB Escherichia coli O127:H6 str. E2348/69 ATP-dependent RNA helicase RhlB YP_002331539.1 4260113 R 574521 CDS YP_002331540.1 215489109 7060810 4261509..4261838 1 NC_011601.1 thioredoxin 4261838 trxA 7060810 trxA Escherichia coli O127:H6 str. E2348/69 thioredoxin YP_002331540.1 4261509 D 574521 CDS YP_002331541.1 215489110 7062267 4261979..4262080 1 NC_011601.1 rho operon leader peptide 4262080 rhoL 7062267 rhoL Escherichia coli O127:H6 str. E2348/69 rho operon leader peptide YP_002331541.1 4261979 D 574521 CDS YP_002331542.1 215489111 7060813 4262165..4263424 1 NC_011601.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4263424 rho 7060813 rho Escherichia coli O127:H6 str. E2348/69 transcription termination factor Rho YP_002331542.1 4262165 D 574521 CDS YP_002331543.1 215489112 7060812 4263434..4263652 1 NC_011601.1 hypothetical protein 4263652 7060812 E2348C_4084 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331543.1 4263434 D 574521 CDS YP_002331544.1 215489113 7062698 4263664..4264767 1 NC_011601.1 UDP-GlcNAc: undecaprenylphosphate GlcNAc-1-phosphate transferase 4264767 rfe 7062698 rfe Escherichia coli O127:H6 str. E2348/69 UDP-GlcNAc: undecaprenylphosphate GlcNAc-1-phosphate transferase YP_002331544.1 4263664 D 574521 CDS YP_002331545.1 215489114 7060794 4264779..4265825 1 NC_011601.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4265825 wzzE 7060794 wzzE Escherichia coli O127:H6 str. E2348/69 lipopolysaccharide biosynthesis protein WzzE YP_002331545.1 4264779 D 574521 CDS YP_002331546.1 215489115 7064855 4265881..4267011 1 NC_011601.1 UDP-N-acetyl glucosamine-2-epimerase 4267011 rffE 7064855 rffE Escherichia coli O127:H6 str. E2348/69 UDP-N-acetyl glucosamine-2-epimerase YP_002331546.1 4265881 D 574521 CDS YP_002331547.1 215489116 7060798 4267008..4268270 1 NC_011601.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4268270 wecC 7060798 wecC Escherichia coli O127:H6 str. E2348/69 UDP-N-acetyl-D-mannosamine dehydrogenase YP_002331547.1 4267008 D 574521 CDS YP_002331548.1 215489117 7060797 4268270..4269337 1 NC_011601.1 dTDP-glucose 4,6-dehydratase 4269337 rffG 7060797 rffG Escherichia coli O127:H6 str. E2348/69 dTDP-glucose 4,6-dehydratase YP_002331548.1 4268270 D 574521 CDS YP_002331549.1 215489118 7060799 4269356..4270237 1 NC_011601.1 glucose-1-phosphate thymidylyltransferase 4270237 rffH 7060799 rffH Escherichia coli O127:H6 str. E2348/69 glucose-1-phosphate thymidylyltransferase YP_002331549.1 4269356 D 574521 CDS YP_002331550.1 215489119 7060800 4270215..4270889 1 NC_011601.1 TDP-fucosamine acetyltransferase 4270889 rffC 7060800 rffC Escherichia coli O127:H6 str. E2348/69 TDP-fucosamine acetyltransferase YP_002331550.1 4270215 D 574521 CDS YP_002331551.1 215489120 7060796 4270894..4272024 1 NC_011601.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4272024 rffA 7060796 rffA Escherichia coli O127:H6 str. E2348/69 TDP-4-oxo-6-deoxy-D-glucose transaminase YP_002331551.1 4270894 D 574521 CDS YP_002331552.1 215489121 7060795 4272026..4273276 1 NC_011601.1 O-antigen translocase 4273276 wzxE 7060795 wzxE Escherichia coli O127:H6 str. E2348/69 O-antigen translocase YP_002331552.1 4272026 D 574521 CDS YP_002331553.1 215489122 7064851 4273273..4274352 1 NC_011601.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4274352 rffT 7064851 rffT Escherichia coli O127:H6 str. E2348/69 4-alpha-L-fucosyltransferase YP_002331553.1 4273273 D 574521 CDS YP_002331554.1 215489123 7060802 4274349..4275701 1 NC_011601.1 enterobacterial common antigen polymerase; common antigen polymerase 4275701 wzyE 7060802 wzyE Escherichia coli O127:H6 str. E2348/69 common antigen polymerase YP_002331554.1 4274349 D 574521 CDS YP_002331555.1 215489124 7064853 4275704..4276444 1 NC_011601.1 UDP-N-acetyl-D-mannosaminuronic acid transferase 4276444 rffM 7064853 rffM Escherichia coli O127:H6 str. E2348/69 UDP-N-acetyl-D-mannosaminuronic acid transferase YP_002331555.1 4275704 D 574521 CDS YP_002331556.1 215489125 7060801 4276635..4278020 1 NC_011601.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transporter 4278020 yifK 7060801 yifK Escherichia coli O127:H6 str. E2348/69 transporter YP_002331556.1 4276635 D 574521 CDS YP_002331557.1 215489126 7061301 4278705..4279940 1 NC_011601.1 regulator of arylsulfatase activity 4279940 aslB 7061301 aslB Escherichia coli O127:H6 str. E2348/69 regulator of arylsulfatase activity YP_002331557.1 4278705 D 574521 CDS YP_002331558.1 215489127 7061409 complement(4280031..4281686) 1 NC_011601.1 acrylsulfatase-like protein 4281686 aslA 7061409 aslA Escherichia coli O127:H6 str. E2348/69 acrylsulfatase-like protein YP_002331558.1 4280031 R 574521 CDS YP_002331559.1 215489128 7065324 complement(4282365..4283561) 1 NC_011601.1 protoheme IX biogenesis protein 4283561 hemY 7065324 hemY Escherichia coli O127:H6 str. E2348/69 protoheme IX biogenesis protein YP_002331559.1 4282365 R 574521 CDS YP_002331560.1 215489129 7064302 complement(4283564..4284781) 1 NC_011601.1 uroporphyrinogen III C-methyltransferase 4284781 hemX 7064302 hemX Escherichia coli O127:H6 str. E2348/69 uroporphyrinogen III C-methyltransferase YP_002331560.1 4283564 R 574521 CDS YP_002331561.1 215489130 7064301 complement(4284803..4285543) 1 NC_011601.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 4285543 hemD 7064301 hemD Escherichia coli O127:H6 str. E2348/69 uroporphyrinogen-III synthase YP_002331561.1 4284803 R 574521 CDS YP_002331562.1 215489131 7064294 complement(4285540..4286502) 1 NC_011601.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 4286502 hemC 7064294 hemC Escherichia coli O127:H6 str. E2348/69 porphobilinogen deaminase YP_002331562.1 4285540 R 574521 CDS YP_002331563.1 215489132 7064293 4286868..4289414 1 NC_011601.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4289414 cyaA 7064293 cyaA Escherichia coli O127:H6 str. E2348/69 adenylate cyclase YP_002331563.1 4286868 D 574521 CDS YP_002331564.1 215489133 7065179 complement(4289454..4289774) 1 NC_011601.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 4289774 cyaY 7065179 cyaY Escherichia coli O127:H6 str. E2348/69 frataxin-like protein YP_002331564.1 4289454 R 574521 CDS YP_002331565.1 215489134 7065180 complement(4289822..4291150) 1 NC_011601.1 hypothetical protein 4291150 7065180 E2348C_4106 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331565.1 4289822 R 574521 CDS YP_002331566.1 215489135 7062699 complement(4291147..4292637) 1 NC_011601.1 lipoprotein 4292637 7062699 E2348C_4107 Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002331566.1 4291147 R 574521 CDS YP_002331567.1 215489136 7062700 4292826..4293029 1 NC_011601.1 lipoprotein 4293029 yifL 7062700 yifL Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002331567.1 4292826 D 574521 CDS YP_002331568.1 215489137 7064820 4293066..4293890 1 NC_011601.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4293890 dapF 7064820 dapF Escherichia coli O127:H6 str. E2348/69 diaminopimelate epimerase YP_002331568.1 4293066 D 574521 CDS YP_002331569.1 215489138 7065224 4293887..4294594 1 NC_011601.1 hypothetical protein 4294594 yigA 7065224 yigA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331569.1 4293887 D 574521 CDS YP_002331570.1 215489139 7064821 4294591..4295487 1 NC_011601.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4295487 xerC 7064821 xerC Escherichia coli O127:H6 str. E2348/69 site-specific tyrosine recombinase XerC YP_002331570.1 4294591 D 574521 CDS YP_002331571.1 215489140 7064863 4295487..4296203 1 NC_011601.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4296203 yigB 7064863 yigB Escherichia coli O127:H6 str. E2348/69 flavin mononucleotide phosphatase YP_002331571.1 4295487 D 574521 CDS YP_002331572.1 215489141 7064822 4296287..4298449 1 NC_011601.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4298449 uvrD 7064822 uvrD Escherichia coli O127:H6 str. E2348/69 DNA-dependent helicase II YP_002331572.1 4296287 D 574521 CDS YP_002331573.1 215489142 7062343 complement(4298504..4299406) 1 NC_011601.1 hypothetical protein 4299406 7062343 E2348C_4114 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331573.1 4298504 R 574521 CDS YP_002331574.1 215489143 7062701 complement(4299489..4300253) 1 NC_011601.1 hypothetical protein 4300253 yigE 7062701 yigE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331574.1 4299489 R 574521 CDS YP_002331575.1 215489144 7064823 4300623..4301573 1 NC_011601.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4301573 corA 7064823 corA Escherichia coli O127:H6 str. E2348/69 magnesium/nickel/cobalt transporter CorA YP_002331575.1 4300623 D 574521 CDS YP_002331576.1 215489145 7062833 complement(4301609..4302106) 1 NC_011601.1 hypothetical protein 4302106 7062833 E2348C_4117 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331576.1 4301609 R 574521 CDS YP_002331577.1 215489146 7062702 complement(4302103..4302951) 1 NC_011601.1 hypothetical protein 4302951 7062702 E2348C_4118 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331577.1 4302103 R 574521 CDS YP_002331578.1 215489147 7062703 complement(4303262..4304152) 1 NC_011601.1 chloramphenical resistance permease 4304152 rarD 7062703 rarD Escherichia coli O127:H6 str. E2348/69 chloramphenical resistance permease YP_002331578.1 4303262 R 574521 CDS YP_002331579.1 215489148 7063949 complement(4304204..4304671) 1 NC_011601.1 hypothetical protein 4304671 yigI 7063949 yigI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331579.1 4304204 R 574521 CDS YP_002331580.1 215489149 7064824 4304836..4305705 1 NC_011601.1 catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4305705 pldA 7064824 pldA Escherichia coli O127:H6 str. E2348/69 phospholipase A YP_002331580.1 4304836 D 574521 CDS YP_002331581.1 215489150 7060754 4305830..4307659 1 NC_011601.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4307659 recQ 7060754 recQ Escherichia coli O127:H6 str. E2348/69 ATP-dependent DNA helicase RecQ YP_002331581.1 4305830 D 574521 CDS YP_002331582.1 215489151 7063984 4307723..4308343 1 NC_011601.1 threonine efflux system 4308343 rhtC 7063984 rhtC Escherichia coli O127:H6 str. E2348/69 threonine efflux system YP_002331582.1 4307723 D 574521 CDS YP_002331583.1 215489152 7060816 complement(4308380..4309240) 1 NC_011601.1 transposase 4309240 7060816 E2348C_4124 Escherichia coli O127:H6 str. E2348/69 transposase YP_002331583.1 4308380 R 574521 CDS YP_002331584.1 215489153 7065004 complement(4309399..4310019) 1 NC_011601.1 homoserine/homoserine lactone efflux protein 4310019 rhtB 7065004 rhtB Escherichia coli O127:H6 str. E2348/69 homoserine/homoserine lactone efflux protein YP_002331584.1 4309399 R 574521 CDS YP_002331585.1 215489154 7060815 4310130..4311152 1 NC_011601.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4311152 pldB 7060815 pldB Escherichia coli O127:H6 str. E2348/69 lysophospholipase L2 YP_002331585.1 4310130 D 574521 CDS YP_002331586.1 215489155 7060755 4311160..4311960 1 NC_011601.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; sugar phosphatase 4311960 yigL 7060755 yigL Escherichia coli O127:H6 str. E2348/69 sugar phosphatase YP_002331586.1 4311160 D 574521 CDS YP_002331587.1 215489156 7064825 4312036..4312935 1 NC_011601.1 hypothetical protein 4312935 yigM 7064825 yigM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331587.1 4312036 D 574521 CDS YP_002331588.1 215489157 7064826 complement(4312823..4313776) 1 NC_011601.1 DNA-binding transcriptional activator MetR 4313776 metR 7064826 metR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator MetR YP_002331588.1 4312823 R 574521 CDS YP_002331589.1 215489158 7063769 4313894..4316155 1 NC_011601.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 4316155 metE 7063769 metE Escherichia coli O127:H6 str. E2348/69 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase YP_002331589.1 4313894 D 574521 CDS YP_002331590.1 215489159 7063759 4316482..4317051 1 NC_011601.1 phosphosugar isomerase 4317051 7063759 E2348C_4131 Escherichia coli O127:H6 str. E2348/69 phosphosugar isomerase YP_002331590.1 4316482 D 574521 CDS YP_002331591.1 215489160 7065084 4317093..4318601 1 NC_011601.1 PTS system, IIB component / IIC component 4318601 7065084 E2348C_4132 Escherichia coli O127:H6 str. E2348/69 PTS system, IIB component / IIC component YP_002331591.1 4317093 D 574521 CDS YP_002331592.1 215489161 7065085 4318652..4320649 1 NC_011601.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 4320649 7065085 E2348C_4133 Escherichia coli O127:H6 str. E2348/69 transketolase YP_002331592.1 4318652 D 574521 CDS YP_002331593.1 215489162 7065086 complement(4320679..4321524) 1 NC_011601.1 RpiR family transcriptional regulator 4321524 7065086 E2348C_4134 Escherichia coli O127:H6 str. E2348/69 RpiR family transcriptional regulator YP_002331593.1 4320679 R 574521 CDS YP_002331594.1 215489163 7065087 complement(4321724..4322629) 1 NC_011601.1 LysR family transcriptional regulator 4322629 7065087 E2348C_4135 Escherichia coli O127:H6 str. E2348/69 LysR family transcriptional regulator YP_002331594.1 4321724 R 574521 CDS YP_002331595.1 215489164 7065088 complement(4322707..4323930) 1 NC_011601.1 permease, cytosine/purine, uracil, thiamine, allantoin family 4323930 7065088 E2348C_4136 Escherichia coli O127:H6 str. E2348/69 permease, cytosine/purine, uracil, thiamine, allantoin family YP_002331595.1 4322707 R 574521 CDS YP_002331596.1 215489165 7065089 complement(4323956..4324345) 1 NC_011601.1 hypothetical protein 4324345 7065089 E2348C_4137 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331596.1 4323956 R 574521 CDS YP_002331597.1 215489166 7065090 complement(4324362..4325318) 1 NC_011601.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 4325318 7065090 E2348C_4138 Escherichia coli O127:H6 str. E2348/69 carbamate kinase YP_002331597.1 4324362 R 574521 CDS YP_002331598.1 215489167 7061132 4325668..4327041 1 NC_011601.1 transposase of ISEc13 4327041 7061132 E2348C_4140 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002331598.1 4325668 D 574521 CDS YP_002331599.1 215489168 7065092 complement(4328290..4329849) 1 NC_011601.1 FdrA-like protein 4329849 7065092 E2348C_4141 Escherichia coli O127:H6 str. E2348/69 FdrA-like protein YP_002331599.1 4328290 R 574521 CDS YP_002331600.1 215489169 7065093 complement(4329944..4330804) 1 NC_011601.1 hypothetical protein 4330804 7065093 E2348C_4142 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331600.1 4329944 R 574521 CDS YP_002331601.1 215489170 7065094 complement(4330810..4331478) 1 NC_011601.1 cysteine hydrolases superfamily protein 4331478 7065094 E2348C_4143 Escherichia coli O127:H6 str. E2348/69 cysteine hydrolases superfamily protein YP_002331601.1 4330810 R 574521 CDS YP_002331602.1 215489171 7065095 complement(4331735..4332544) 1 NC_011601.1 hydrolase 4332544 ysgA 7065095 ysgA Escherichia coli O127:H6 str. E2348/69 hydrolase YP_002331602.1 4331735 R 574521 CDS YP_002331603.1 215489172 7063238 4332806..4333567 1 NC_011601.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4333567 udp 7063238 udp Escherichia coli O127:H6 str. E2348/69 uridine phosphorylase YP_002331603.1 4332806 D 574521 CDS YP_002331604.1 215489173 7062301 4333708..4335135 1 NC_011601.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4335135 rmuC 7062301 rmuC Escherichia coli O127:H6 str. E2348/69 DNA recombination protein RmuC YP_002331604.1 4333708 D 574521 CDS YP_002331605.1 215489174 7060845 4335230..4335985 1 NC_011601.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4335985 ubiE 7060845 ubiE Escherichia coli O127:H6 str. E2348/69 ubiquinone/menaquinone biosynthesis methyltransferase YP_002331605.1 4335230 D 574521 CDS YP_002331606.1 215489175 7062294 4335999..4336604 1 NC_011601.1 hypothetical protein 4336604 yigP 7062294 yigP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331606.1 4335999 D 574521 CDS YP_002331607.1 215489176 7064827 4336601..4338241 1 NC_011601.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 4338241 ubiB 7064827 ubiB Escherichia coli O127:H6 str. E2348/69 ubiquinone biosynthesis protein UbiB YP_002331607.1 4336601 D 574521 CDS YP_002331608.1 215489177 7062291 4338320..4338589 1 NC_011601.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase A 4338589 tatA 7062291 tatA Escherichia coli O127:H6 str. E2348/69 twin arginine translocase A YP_002331608.1 4338320 D 574521 CDS YP_002331609.1 215489178 7061755 4338593..4339108 1 NC_011601.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4339108 tatB 7061755 tatB Escherichia coli O127:H6 str. E2348/69 sec-independent translocase YP_002331609.1 4338593 D 574521 CDS YP_002331610.1 215489179 7061756 4339111..4339887 1 NC_011601.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4339887 tatC 7061756 tatC Escherichia coli O127:H6 str. E2348/69 twin-arginine protein translocation system subunit TatC YP_002331610.1 4339111 D 574521 CDS YP_002331611.1 215489180 7061757 4339929..4340711 1 NC_011601.1 magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4340711 tatD 7061757 tatD Escherichia coli O127:H6 str. E2348/69 DNase TatD YP_002331611.1 4339929 D 574521 CDS YP_002331612.1 215489181 7061758 complement(4340708..4341196) 1 NC_011601.1 transcriptional activator RfaH 4341196 rfaH 7061758 rfaH Escherichia coli O127:H6 str. E2348/69 transcriptional activator RfaH YP_002331612.1 4340708 R 574521 CDS YP_002331613.1 215489182 7060785 4341363..4342856 1 NC_011601.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 4342856 ubiD 7060785 ubiD Escherichia coli O127:H6 str. E2348/69 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_002331613.1 4341363 D 574521 CDS YP_002331614.1 215489183 7062293 4342902..4343603 1 NC_011601.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4343603 fre 7062293 fre Escherichia coli O127:H6 str. E2348/69 FMN reductase YP_002331614.1 4342902 D 574521 CDS YP_002331615.1 215489184 7061953 complement(4343886..4345049) 1 NC_011601.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 4345049 fadA 7061953 fadA Escherichia coli O127:H6 str. E2348/69 3-ketoacyl-CoA thiolase YP_002331615.1 4343886 R 574521 CDS YP_002331616.1 215489185 7062071 complement(4345059..4347248) 1 NC_011601.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 4347248 fadB 7062071 fadB Escherichia coli O127:H6 str. E2348/69 multifunctional fatty acid oxidation complex subunit alpha YP_002331616.1 4345059 R 574521 CDS YP_002331617.1 215489186 7062072 4347438..4348769 1 NC_011601.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4348769 pepQ 7062072 pepQ Escherichia coli O127:H6 str. E2348/69 proline dipeptidase YP_002331617.1 4347438 D 574521 CDS YP_002331618.1 215489187 7060704 4348769..4349383 1 NC_011601.1 hypothetical protein 4349383 yigZ 7060704 yigZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331618.1 4348769 D 574521 CDS YP_002331619.1 215489188 7064828 4349422..4350873 1 NC_011601.1 potassium transporter 4350873 trkH 7064828 trkH Escherichia coli O127:H6 str. E2348/69 potassium transporter YP_002331619.1 4349422 D 574521 CDS YP_002331620.1 215489189 7062240 4350885..4351430 1 NC_011601.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4351430 hemG 7062240 hemG Escherichia coli O127:H6 str. E2348/69 protoporphyrinogen oxidase YP_002331620.1 4350885 D 574521 CDS YP_002331621.1 215489190 7061896 complement(4357019..4357546) 1 NC_011601.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B 4357546 mobB 7061896 mobB Escherichia coli O127:H6 str. E2348/69 molybdopterin-guanine dinucleotide biosynthesis protein B YP_002331621.1 4357019 R 574521 CDS YP_002331622.1 215489191 7063811 complement(4357528..4358112) 1 NC_011601.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 4358112 mobA 7063811 mobA Escherichia coli O127:H6 str. E2348/69 molybdopterin-guanine dinucleotide biosynthesis protein MobA YP_002331622.1 4357528 R 574521 CDS YP_002331623.1 215489192 7063810 4358182..4358451 1 NC_011601.1 hypothetical protein 4358451 yihD 7063810 yihD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331623.1 4358182 D 574521 CDS YP_002331624.1 215489193 7064830 4358528..4359514 1 NC_011601.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4359514 rdoA 7064830 rdoA Escherichia coli O127:H6 str. E2348/69 serine/threonine protein kinase YP_002331624.1 4358528 D 574521 CDS YP_002331625.1 215489194 7063974 4359531..4360157 1 NC_011601.1 protein disulfide isomerase I 4360157 dsbA 7063974 dsbA Escherichia coli O127:H6 str. E2348/69 protein disulfide isomerase I YP_002331625.1 4359531 D 574521 CDS YP_002331626.1 215489195 7065062 4360312..4361742 1 NC_011601.1 hypothetical protein 4361742 yihF 7065062 yihF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331626.1 4360312 D 574521 CDS YP_002331627.1 215489196 7064831 complement(4361783..4362715) 1 NC_011601.1 acyltransferase 4362715 yihG 7064831 yihG Escherichia coli O127:H6 str. E2348/69 acyltransferase YP_002331627.1 4361783 R 574521 CDS YP_002331628.1 215489197 7064832 4363079..4365865 1 NC_011601.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4365865 polA 7064832 polA Escherichia coli O127:H6 str. E2348/69 DNA polymerase I YP_002331628.1 4363079 D 574521 CDS YP_002331629.1 215489198 7062748 complement(4366247..4366879) 1 NC_011601.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 4366879 engB 7062748 engB Escherichia coli O127:H6 str. E2348/69 ribosome biogenesis GTP-binding protein YsxC YP_002331629.1 4366247 R 574521 CDS YP_002331630.1 215489199 7065164 4367461..4367970 1 NC_011601.1 hypothetical protein 4367970 yihI 7065164 yihI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331630.1 4367461 D 574521 CDS YP_002331631.1 215489200 7064833 4368159..4369532 1 NC_011601.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4369532 hemN 7064833 hemN Escherichia coli O127:H6 str. E2348/69 coproporphyrinogen III oxidase YP_002331631.1 4368159 D 574521 CDS YP_002331632.1 215489201 7064300 complement(4369987..4371396) 1 NC_011601.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 4371396 glnG 7064300 glnG Escherichia coli O127:H6 str. E2348/69 nitrogen regulation protein NR(I) YP_002331632.1 4369987 R 574521 CDS YP_002331633.1 215489202 7061680 complement(4371408..4372457) 1 NC_011601.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 4372457 glnL 7061680 glnL Escherichia coli O127:H6 str. E2348/69 nitrogen regulation protein NR(II) YP_002331633.1 4371408 R 574521 CDS YP_002331634.1 215489203 7061683 complement(4372631..4374040) 1 NC_011601.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 4374040 glnA 7061683 glnA Escherichia coli O127:H6 str. E2348/69 glutamine synthetase YP_002331634.1 4372631 R 574521 CDS YP_002331635.1 215489204 7061676 4374413..4376236 1 NC_011601.1 GTP-binding protein 4376236 typA 7061676 typA Escherichia coli O127:H6 str. E2348/69 GTP-binding protein YP_002331635.1 4374413 D 574521 CDS YP_002331636.1 215489205 7062282 complement(4376343..4377131) 1 NC_011601.1 DNA-binding transcriptional regulator 4377131 7062282 E2348C_4178 Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002331636.1 4376343 R 574521 CDS YP_002331637.1 215489206 7065096 complement(4377171..4378067) 1 NC_011601.1 sugar kinase 4378067 7065096 E2348C_4179 Escherichia coli O127:H6 str. E2348/69 sugar kinase YP_002331637.1 4377171 R 574521 CDS YP_002331638.1 215489207 7065097 4378240..4379118 1 NC_011601.1 oxidoreductase with NAD(P)-binding Rossmann-fold domain 4379118 7065097 E2348C_4180 Escherichia coli O127:H6 str. E2348/69 oxidoreductase with NAD(P)-binding Rossmann-fold domain YP_002331638.1 4378240 D 574521 CDS YP_002331639.1 215489208 7065098 4379143..4380030 1 NC_011601.1 aldolase 4380030 7065098 E2348C_4181 Escherichia coli O127:H6 str. E2348/69 aldolase YP_002331639.1 4379143 D 574521 CDS YP_002331640.1 215489209 7065099 4380063..4381073 1 NC_011601.1 dehydrogenase 4381073 7065099 E2348C_4182 Escherichia coli O127:H6 str. E2348/69 dehydrogenase YP_002331640.1 4380063 D 574521 CDS YP_002331641.1 215489210 7065100 4381143..4382576 1 NC_011601.1 transporter 4382576 7065100 E2348C_4183 Escherichia coli O127:H6 str. E2348/69 transporter YP_002331641.1 4381143 D 574521 CDS YP_002331642.1 215489211 7065101 4382675..4384024 1 NC_011601.1 shikimate transporter 4384024 7065101 E2348C_4184 Escherichia coli O127:H6 str. E2348/69 shikimate transporter YP_002331642.1 4382675 D 574521 CDS YP_002331643.1 215489212 7065102 4384014..4384901 1 NC_011601.1 aldose-1-epimerase 4384901 yihW 7065102 yihW Escherichia coli O127:H6 str. E2348/69 aldose-1-epimerase YP_002331643.1 4384014 D 574521 CDS YP_002331644.1 215489213 7064834 4385042..4385641 1 NC_011601.1 phosphatase 4385641 yihX 7064834 yihX Escherichia coli O127:H6 str. E2348/69 phosphatase YP_002331644.1 4385042 D 574521 CDS YP_002331645.1 215489214 7064835 4385635..4386507 1 NC_011601.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4386507 rbn 7064835 rbn Escherichia coli O127:H6 str. E2348/69 ribonuclease BN YP_002331645.1 4385635 D 574521 CDS YP_002331646.1 215489215 7064836 4386504..4386941 1 NC_011601.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4386941 dtd 7064836 dtd Escherichia coli O127:H6 str. E2348/69 D-tyrosyl-tRNA(Tyr) deacylase YP_002331646.1 4386504 D 574521 CDS YP_002331647.1 215489216 7065070 4386986..4387927 1 NC_011601.1 acetyltransferase 4387927 yiiD 7065070 yiiD Escherichia coli O127:H6 str. E2348/69 acetyltransferase YP_002331647.1 4386986 D 574521 CDS YP_002331648.1 215489217 7064837 complement(4387991..4388899) 1 NC_011601.1 lipase 4388899 7064837 E2348C_4190 Escherichia coli O127:H6 str. E2348/69 lipase YP_002331648.1 4387991 R 574521 CDS YP_002331649.1 215489218 7065103 4389128..4389439 1 NC_011601.1 hypothetical protein 4389439 7065103 E2348C_4191 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331649.1 4389128 D 574521 CDS YP_002331650.1 215489219 7065104 4389440..4389730 1 NC_011601.1 hypothetical protein 4389730 7065104 E2348C_4192 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331650.1 4389440 D 574521 CDS YP_002331651.1 215489220 7065105 4390335..4390553 1 NC_011601.1 transcriptional regulator 4390553 yiiE 7065105 yiiE Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002331651.1 4390335 D 574521 CDS YP_002331652.1 215489221 7064838 complement(4390777..4391706) 1 NC_011601.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 4391706 fdhE 7064838 fdhE Escherichia coli O127:H6 str. E2348/69 formate dehydrogenase accessory protein FdhE YP_002331652.1 4390777 R 574521 CDS YP_002331653.1 215489222 7062086 complement(4391703..4392338) 1 NC_011601.1 cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 4392338 fdoI 7062086 fdoI Escherichia coli O127:H6 str. E2348/69 formate dehydrogenase-O subunit gamma YP_002331653.1 4391703 R 574521 CDS YP_002331654.1 215489223 7062093 complement(4392335..4393237) 1 NC_011601.1 formate dehydrogenase-O, Fe-S subunit FdoH 4393237 fdoH 7062093 fdoH Escherichia coli O127:H6 str. E2348/69 formate dehydrogenase-O, Fe-S subunit FdoH YP_002331654.1 4392335 R 574521 CDS YP_002331655.1 215489224 7062092 complement(4393250..4396300) 1 NC_011601.1 selenocysteine (Sec=>U); formate dehydrogenase-O, large subunit 4396300 fdoG 7062092 fdoG Escherichia coli O127:H6 str. E2348/69 formate dehydrogenase-O, large subunit YP_002331655.1 4393250 R 574521 CDS YP_002331656.1 215489225 7062091 4396494..4397330 1 NC_011601.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4397330 fdhD 7062091 fdhD Escherichia coli O127:H6 str. E2348/69 formate dehydrogenase accessory protein YP_002331656.1 4396494 D 574521 CDS YP_002331657.1 215489226 7062085 4397641..4399476 1 NC_011601.1 heat shock protein (Hsp90-family) 4399476 7062085 E2348C_4199 Escherichia coli O127:H6 str. E2348/69 heat shock protein (Hsp90-family) YP_002331657.1 4397641 D 574521 CDS YP_002331658.1 215489227 7065106 4399478..4401784 1 NC_011601.1 hypothetical protein 4401784 7065106 E2348C_4200 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331658.1 4399478 D 574521 CDS YP_002331659.1 215489228 7065107 complement(4401882..4403630) 1 NC_011601.1 repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; frv operon regulatory protein 4403630 frvR 7065107 frvR Escherichia coli O127:H6 str. E2348/69 frv operon regulatory protein YP_002331659.1 4401882 R 574521 CDS YP_002331660.1 215489229 7061965 complement(4403630..4404700) 1 NC_011601.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; fructose-specific phosphotransferase system protein FrvX 4404700 frvX 7061965 frvX Escherichia coli O127:H6 str. E2348/69 fructose-specific phosphotransferase system protein FrvX YP_002331660.1 4403630 R 574521 CDS YP_002331661.1 215489230 7061966 complement(4404690..4406141) 1 NC_011601.1 PTS system transporter subunits IIBC 4406141 frvB 7061966 frvB Escherichia coli O127:H6 str. E2348/69 PTS system transporter subunits IIBC YP_002331661.1 4404690 R 574521 CDS YP_002331662.1 215489231 7061964 complement(4406152..4406598) 1 NC_011601.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; fructose-like phosphotransferase system subunit EIIA 4406598 frvA 7061964 frvA Escherichia coli O127:H6 str. E2348/69 fructose-like phosphotransferase system subunit EIIA YP_002331662.1 4406152 R 574521 CDS YP_002331663.1 215489232 7061963 4407074..4408468 1 NC_011601.1 glycoprotein 4408468 7061963 E2348C_4205 Escherichia coli O127:H6 str. E2348/69 glycoprotein YP_002331663.1 4407074 D 574521 CDS YP_002331664.1 215489233 7065108 complement(4408509..4408823) 1 NC_011601.1 L-rhamnose mutarotase 4408823 rhaM 7065108 rhaM Escherichia coli O127:H6 str. E2348/69 L-rhamnose mutarotase YP_002331664.1 4408509 R 574521 CDS YP_002331665.1 215489234 7060806 complement(4408833..4409657) 1 NC_011601.1 rhamnulose-1-phosphate aldolase 4409657 rhaD 7060806 rhaD Escherichia coli O127:H6 str. E2348/69 rhamnulose-1-phosphate aldolase YP_002331665.1 4408833 R 574521 CDS YP_002331666.1 215489235 7060805 complement(4409848..4411107) 1 NC_011601.1 catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 4411107 rhaA 7060805 rhaA Escherichia coli O127:H6 str. E2348/69 L-rhamnose isomerase YP_002331666.1 4409848 R 574521 CDS YP_002331667.1 215489236 7060803 complement(4411104..4412573) 1 NC_011601.1 catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 4412573 rhaB 7060803 rhaB Escherichia coli O127:H6 str. E2348/69 rhamnulokinase YP_002331667.1 4411104 R 574521 CDS YP_002331668.1 215489237 7060804 4412861..4413697 1 NC_011601.1 activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4413697 rhaS 7060804 rhaS Escherichia coli O127:H6 str. E2348/69 transcriptional activator RhaS YP_002331668.1 4412861 D 574521 CDS YP_002331669.1 215489238 7060808 4413681..4414619 1 NC_011601.1 activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4414619 rhaR 7060808 rhaR Escherichia coli O127:H6 str. E2348/69 transcriptional activator RhaR YP_002331669.1 4413681 D 574521 CDS YP_002331670.1 215489239 7060807 complement(4414616..4415650) 1 NC_011601.1 transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter 4415650 rhaT 7060807 rhaT Escherichia coli O127:H6 str. E2348/69 rhamnose-proton symporter YP_002331670.1 4414616 R 574521 CDS YP_002331671.1 215489240 7060809 4415936..4416556 1 NC_011601.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4416556 sodA 7060809 sodA Escherichia coli O127:H6 str. E2348/69 superoxide dismutase YP_002331671.1 4415936 D 574521 CDS YP_002331672.1 215489241 7062732 4416816..4417799 1 NC_011601.1 transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4417799 kdgT 7062732 kdgT Escherichia coli O127:H6 str. E2348/69 2-keto-3-deoxygluconate permease YP_002331672.1 4416816 D 574521 CDS YP_002331673.1 215489242 7063571 4417948..4418622 1 NC_011601.1 hypothetical protein 4418622 yiiM 7063571 yiiM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331673.1 4417948 D 574521 CDS YP_002331674.1 215489243 7064839 complement(4418728..4420101) 1 NC_011601.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 4420101 cpxA 7064839 cpxA Escherichia coli O127:H6 str. E2348/69 two-component sensor protein YP_002331674.1 4418728 R 574521 CDS YP_002331675.1 215489244 7062838 complement(4420098..4420796) 1 NC_011601.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 4420796 cpxR 7062838 cpxR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator CpxR YP_002331675.1 4420098 R 574521 CDS YP_002331676.1 215489245 7062840 4420946..4421446 1 NC_011601.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; repressor CpxP 4421446 cpxP 7062840 cpxP Escherichia coli O127:H6 str. E2348/69 repressor CpxP YP_002331676.1 4420946 D 574521 CDS YP_002331677.1 215489246 7062839 4421594..4422496 1 NC_011601.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4422496 fieF 7062839 fieF Escherichia coli O127:H6 str. E2348/69 ferrous iron efflux protein F YP_002331677.1 4421594 D 574521 CDS YP_002331678.1 215489247 7062118 4422677..4423639 1 NC_011601.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4423639 pfkA 7062118 pfkA Escherichia coli O127:H6 str. E2348/69 6-phosphofructokinase YP_002331678.1 4422677 D 574521 CDS YP_002331679.1 215489248 7060706 4423959..4424948 1 NC_011601.1 sulfate transporter subunit 4424948 sbp 7060706 sbp Escherichia coli O127:H6 str. E2348/69 sulfate transporter subunit YP_002331679.1 4423959 D 574521 CDS YP_002331680.1 215489249 7065337 4425055..4425810 1 NC_011601.1 CDP-diacylglycerol pyrophosphatase 4425810 cdh 7065337 cdh Escherichia coli O127:H6 str. E2348/69 CDP-diacylglycerol pyrophosphatase YP_002331680.1 4425055 D 574521 CDS YP_002331681.1 215489250 7064342 complement(4425865..4426632) 1 NC_011601.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 4426632 tpiA 7064342 tpiA Escherichia coli O127:H6 str. E2348/69 triosephosphate isomerase YP_002331681.1 4425865 R 574521 CDS YP_002331682.1 215489251 7062229 complement(4426740..4427339) 1 NC_011601.1 hypothetical protein 4427339 yiiQ 7062229 yiiQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331682.1 4426740 R 574521 CDS YP_002331683.1 215489252 7064840 4427440..4427880 1 NC_011601.1 hypothetical protein 4427880 yiiR 7064840 yiiR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331683.1 4427440 D 574521 CDS YP_002331684.1 215489253 7064841 4428092..4428391 1 NC_011601.1 hypothetical protein 4428391 yiiS 7064841 yiiS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331684.1 4428092 D 574521 CDS YP_002331685.1 215489254 7064842 4428418..4428846 1 NC_011601.1 with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4428846 uspD 7064842 uspD Escherichia coli O127:H6 str. E2348/69 universal stress protein UspD YP_002331685.1 4428418 D 574521 CDS YP_002331686.1 215489255 7062335 complement(4428851..4429597) 1 NC_011601.1 ferredoxin-NADP reductase 4429597 fpr 7062335 fpr Escherichia coli O127:H6 str. E2348/69 ferredoxin-NADP reductase YP_002331686.1 4428851 R 574521 CDS YP_002331687.1 215489256 7061947 complement(4429694..4430704) 1 NC_011601.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 4430704 glpX 7061947 glpX Escherichia coli O127:H6 str. E2348/69 fructose 1,6-bisphosphatase II YP_002331687.1 4429694 R 574521 CDS YP_002331688.1 215489257 7061703 complement(4430875..4432383) 1 NC_011601.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 4432383 glpK 7061703 glpK Escherichia coli O127:H6 str. E2348/69 glycerol kinase YP_002331688.1 4430875 R 574521 CDS YP_002331689.1 215489258 7061699 complement(4432406..4433251) 1 NC_011601.1 glycerol facilitator 4433251 glpF 7061699 glpF Escherichia coli O127:H6 str. E2348/69 glycerol facilitator YP_002331689.1 4432406 R 574521 CDS YP_002331690.1 215489259 7061697 4433676..4433921 1 NC_011601.1 hypothetical protein 4433921 yiiU 7061697 yiiU Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331690.1 4433676 D 574521 CDS YP_002331691.1 215489260 7064070 complement(4434006..4434491) 1 NC_011601.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4434491 rraA 7064070 rraA Escherichia coli O127:H6 str. E2348/69 ribonuclease activity regulator protein RraA YP_002331691.1 4434006 R 574521 CDS YP_002331692.1 215489261 7061894 complement(4434584..4435510) 1 NC_011601.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 4435510 menA 7061894 menA Escherichia coli O127:H6 str. E2348/69 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_002331692.1 4434584 R 574521 CDS YP_002331693.1 215489262 7063748 complement(4435577..4436908) 1 NC_011601.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 4436908 hslU 7063748 hslU Escherichia coli O127:H6 str. E2348/69 ATP-dependent protease ATP-binding subunit HslU YP_002331693.1 4435577 R 574521 CDS YP_002331694.1 215489263 7062185 complement(4436918..4437448) 1 NC_011601.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 4437448 hslV 7062185 hslV Escherichia coli O127:H6 str. E2348/69 ATP-dependent protease peptidase subunit YP_002331694.1 4436918 R 574521 CDS YP_002331695.1 215489264 7062186 complement(4437541..4438425) 1 NC_011601.1 25 aa deleted; cell division protein FtsN 4438425 ftsN 7062186 ftsN Escherichia coli O127:H6 str. E2348/69 cell division protein FtsN YP_002331695.1 4437541 R 574521 CDS YP_002331696.1 215489265 7061587 complement(4438517..4439542) 1 NC_011601.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 4439542 cytR 7061587 cytR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator CytR YP_002331696.1 4438517 R 574521 CDS YP_002331697.1 215489266 7065211 complement(4439698..4441896) 1 NC_011601.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 4441896 priA 7065211 priA Escherichia coli O127:H6 str. E2348/69 primosome assembly protein PriA YP_002331697.1 4439698 R 574521 CDS YP_002331698.1 215489267 7061288 4442099..4442311 1 NC_011601.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4442311 rpmE 7061288 rpmE Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L31 YP_002331698.1 4442099 D 574521 CDS YP_002331699.1 215489268 7061857 complement(4442372..4442980) 1 NC_011601.1 member of the NlpC/P60 superfamily of peptidases; peptidoglycan peptidase 4442980 yiiX 7061857 yiiX Escherichia coli O127:H6 str. E2348/69 peptidoglycan peptidase YP_002331699.1 4442372 R 574521 CDS YP_002331700.1 215489269 7064071 complement(4443040..4443357) 1 NC_011601.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 4443357 metJ 7064071 metJ Escherichia coli O127:H6 str. E2348/69 transcriptional repressor protein MetJ YP_002331700.1 4443040 R 574521 CDS YP_002331701.1 215489270 7063764 4443634..4444794 1 NC_011601.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4444794 metB 7063764 metB Escherichia coli O127:H6 str. E2348/69 cystathionine gamma-synthase YP_002331701.1 4443634 D 574521 CDS YP_002331702.1 215489271 7063757 4444797..4447229 1 NC_011601.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4447229 metL 7063757 metL Escherichia coli O127:H6 str. E2348/69 bifunctional aspartate kinase II/homoserine dehydrogenase II YP_002331702.1 4444797 D 574521 CDS YP_002331703.1 215489272 7063766 complement(4447447..4448307) 1 NC_011601.1 nucleoside-specific channel-forming protein Tsx 4448307 7063766 E2348C_4245 Escherichia coli O127:H6 str. E2348/69 nucleoside-specific channel-forming protein Tsx YP_002331703.1 4447447 R 574521 CDS YP_002331704.1 215489273 7065109 complement(4448384..4450003) 1 NC_011601.1 5'-nucleotidase/2', 3'-cyclic phosphodiesterase 4450003 7065109 E2348C_4246 Escherichia coli O127:H6 str. E2348/69 5'-nucleotidase/2', 3'-cyclic phosphodiesterase YP_002331704.1 4448384 R 574521 CDS YP_002331705.1 215489274 7065110 complement(4450044..4451597) 1 NC_011601.1 5'-nucleotidase 4451597 7065110 E2348C_4247 Escherichia coli O127:H6 str. E2348/69 5'-nucleotidase YP_002331705.1 4450044 R 574521 CDS YP_002331706.1 215489275 7065111 complement(4451827..4452951) 1 NC_011601.1 hypothetical protein 4452951 7065111 E2348C_4248 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331706.1 4451827 R 574521 CDS YP_002331707.1 215489276 7065112 4453084..4454637 1 NC_011601.1 5'-nucleotidase/2', 3'-cyclic phosphodiesterase 4454637 7065112 E2348C_4249 Escherichia coli O127:H6 str. E2348/69 5'-nucleotidase/2', 3'-cyclic phosphodiesterase YP_002331707.1 4453084 D 574521 CDS YP_002331708.1 215489277 7065113 4455019..4455909 1 NC_011601.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4455909 metF 7065113 metF Escherichia coli O127:H6 str. E2348/69 5,10-methylenetetrahydrofolate reductase YP_002331708.1 4455019 D 574521 CDS YP_002331709.1 215489278 7063760 4456238..4458418 1 NC_011601.1 catalase/hydroperoxidase HPI (I) 4458418 katG 7063760 katG Escherichia coli O127:H6 str. E2348/69 catalase/hydroperoxidase HPI (I) YP_002331709.1 4456238 D 574521 CDS YP_002331710.1 215489279 7063564 4458512..4459417 1 NC_011601.1 permease 4459417 yijE 7063564 yijE Escherichia coli O127:H6 str. E2348/69 permease YP_002331710.1 4458512 D 574521 CDS YP_002331711.1 215489280 7064073 complement(4459444..4460061) 1 NC_011601.1 hypothetical protein 4460061 yijF 7064073 yijF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331711.1 4459444 R 574521 CDS YP_002331712.1 215489281 7061133 4460258..4460779 1 NC_011601.1 transposase Orf1 of IS1397 4460779 7061133 E2348C_4254 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS1397 YP_002331712.1 4460258 D 574521 CDS YP_002331713.1 215489282 7061134 4461603..4462679 1 NC_011601.1 transposase of ISEc21 4462679 7061134 E2348C_4256 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc21 YP_002331713.1 4461603 D 574521 CDS YP_002331714.1 215489283 7065115 complement(4463144..4464247) 1 NC_011601.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 4464247 gldA 7065115 gldA Escherichia coli O127:H6 str. E2348/69 glycerol dehydrogenase YP_002331714.1 4463144 R 574521 CDS YP_002331715.1 215489284 7061665 complement(4464258..4464920) 1 NC_011601.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 4464920 fsaB 7061665 fsaB Escherichia coli O127:H6 str. E2348/69 fructose-6-phosphate aldolase YP_002331715.1 4464258 R 574521 CDS YP_002331716.1 215489285 7061974 complement(4464932..4467433) 1 NC_011601.1 fused PTS enzymes: Hpr component/enzyme I component/enzyme IIA component 4467433 ptsA 7061974 ptsA Escherichia coli O127:H6 str. E2348/69 fused PTS enzymes: Hpr component/enzyme I component/enzyme IIA component YP_002331716.1 4464932 R 574521 CDS YP_002331717.1 215489286 7061337 4467742..4468821 1 NC_011601.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; fructose-like permease EIIC subunit 2 4468821 frwC 7061337 frwC Escherichia coli O127:H6 str. E2348/69 fructose-like permease EIIC subunit 2 YP_002331717.1 4467742 D 574521 CDS YP_002331718.1 215489287 7061968 4468836..4469156 1 NC_011601.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; PTS system fructose-like transporter subunit EIIB 4469156 frwB 7061968 frwB Escherichia coli O127:H6 str. E2348/69 PTS system fructose-like transporter subunit EIIB YP_002331718.1 4468836 D 574521 CDS YP_002331719.1 215489288 7061967 4469207..4471504 1 NC_011601.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; formate acetyltransferase 2 4471504 pflD 7061967 pflD Escherichia coli O127:H6 str. E2348/69 formate acetyltransferase 2 YP_002331719.1 4469207 D 574521 CDS YP_002331720.1 215489289 7060711 4471470..4472348 1 NC_011601.1 pyruvate formate lyase II activase 4472348 pflC 7060711 pflC Escherichia coli O127:H6 str. E2348/69 pyruvate formate lyase II activase YP_002331720.1 4471470 D 574521 CDS YP_002331721.1 215489290 7060710 4472350..4472691 1 NC_011601.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; fructose-like phosphotransferase EIIB subunit 3 4472691 frwD 7060710 frwD Escherichia coli O127:H6 str. E2348/69 fructose-like phosphotransferase EIIB subunit 3 YP_002331721.1 4472350 D 574521 CDS YP_002331722.1 215489291 7061969 complement(4472678..4473529) 1 NC_011601.1 DNA-binding transcriptional regulator 4473529 yijO 7061969 yijO Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002331722.1 4472678 R 574521 CDS YP_002331723.1 215489292 7064074 complement(4473755..4475488) 1 NC_011601.1 hypothetical protein 4475488 yijP 7064074 yijP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331723.1 4473755 R 574521 CDS YP_002331724.1 215489293 7064075 complement(4475671..4478322) 1 NC_011601.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 4478322 ppc 7064075 ppc Escherichia coli O127:H6 str. E2348/69 phosphoenolpyruvate carboxylase YP_002331724.1 4475671 R 574521 CDS YP_002331725.1 215489294 7061263 complement(4478624..4479775) 1 NC_011601.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 4479775 argE 7061263 argE Escherichia coli O127:H6 str. E2348/69 acetylornithine deacetylase YP_002331725.1 4478624 R 574521 CDS YP_002331726.1 215489295 7061369 4479929..4480933 1 NC_011601.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4480933 argC 7061369 argC Escherichia coli O127:H6 str. E2348/69 N-acetyl-gamma-glutamyl-phosphate reductase YP_002331726.1 4479929 D 574521 CDS YP_002331727.1 215489296 7061367 4480944..4481717 1 NC_011601.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4481717 argB 7061367 argB Escherichia coli O127:H6 str. E2348/69 acetylglutamate kinase YP_002331727.1 4480944 D 574521 CDS YP_002331728.1 215489297 7061366 4481778..4483151 1 NC_011601.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4483151 argH 7061366 argH Escherichia coli O127:H6 str. E2348/69 argininosuccinate lyase YP_002331728.1 4481778 D 574521 CDS YP_002331729.1 215489298 7061371 4483649..4484863 1 NC_011601.1 dehydratase 4484863 7061371 E2348C_4273 Escherichia coli O127:H6 str. E2348/69 dehydratase YP_002331729.1 4483649 D 574521 CDS YP_002331730.1 215489299 7065116 4484930..4486213 1 NC_011601.1 transporter 4486213 7065116 E2348C_4274 Escherichia coli O127:H6 str. E2348/69 transporter YP_002331730.1 4484930 D 574521 CDS YP_002331731.1 215489300 7062898 4486465..4487382 1 NC_011601.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4487382 oxyR 7062898 oxyR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator OxyR YP_002331731.1 4486465 D 574521 CDS YP_002331732.1 215489301 7062897 complement(4487365..4488765) 1 NC_011601.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 4488765 sthA 7062897 sthA Escherichia coli O127:H6 str. E2348/69 soluble pyridine nucleotide transhydrogenase YP_002331732.1 4487365 R 574521 CDS YP_002331733.1 215489302 7062775 4489095..4490261 1 NC_011601.1 amino acid amidohydrolase 4490261 7062775 E2348C_4277 Escherichia coli O127:H6 str. E2348/69 amino acid amidohydrolase YP_002331733.1 4489095 D 574521 CDS YP_002331734.1 215489303 7065118 4490304..4491620 1 NC_011601.1 membrane transport/symporter protein 4491620 7065118 E2348C_4278 Escherichia coli O127:H6 str. E2348/69 membrane transport/symporter protein YP_002331734.1 4490304 D 574521 CDS YP_002331735.1 215489304 7065119 4491670..4492374 1 NC_011601.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4492374 fabR 7065119 fabR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor FabR YP_002331735.1 4491670 D 574521 CDS YP_002331736.1 215489305 7062069 4492374..4492733 1 NC_011601.1 hypothetical protein 4492733 yijD 7062069 yijD Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331736.1 4492374 D 574521 CDS YP_002331737.1 215489306 7064072 complement(4492773..4493873) 1 NC_011601.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 4493873 trmA 7064072 trmA Escherichia coli O127:H6 str. E2348/69 tRNA (uracil-5-)-methyltransferase YP_002331737.1 4492773 R 574521 CDS YP_002331738.1 215489307 7061157 4494242..4496125 1 NC_011601.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4496125 btuB 7061157 btuB Escherichia coli O127:H6 str. E2348/69 vitamin B12/cobalamin outer membrane transporter YP_002331738.1 4494242 D 574521 CDS YP_002331739.1 215489308 7062534 4496070..4496927 1 NC_011601.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4496927 murI 7062534 murI Escherichia coli O127:H6 str. E2348/69 glutamate racemase YP_002331739.1 4496070 D 574521 CDS YP_002331740.1 215489309 7064526 4502453..4503481 1 NC_011601.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4503481 murB 7064526 murB Escherichia coli O127:H6 str. E2348/69 UDP-N-acetylenolpyruvoylglucosamine reductase YP_002331740.1 4502453 D 574521 CDS YP_002331741.1 215489310 7060888 4503478..4504443 1 NC_011601.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4504443 birA 7060888 birA Escherichia coli O127:H6 str. E2348/69 biotin--protein ligase YP_002331741.1 4503478 D 574521 CDS YP_002331742.1 215489311 7062526 complement(4504472..4505422) 1 NC_011601.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 4505422 coaA 7062526 coaA Escherichia coli O127:H6 str. E2348/69 pantothenate kinase YP_002331742.1 4504472 R 574521 CDS YP_002331743.1 215489312 7061798 4506340..4507524 1 NC_011601.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4507524 tufB 7061798 tufB Escherichia coli O127:H6 str. E2348/69 elongation factor Tu YP_002331743.1 4506340 D 574521 CDS YP_002331744.1 215489313 7062280 4507754..4508137 1 NC_011601.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4508137 secE 7062280 secE Escherichia coli O127:H6 str. E2348/69 preprotein translocase subunit SecE YP_002331744.1 4507754 D 574521 CDS YP_002331745.1 215489314 7065355 4508139..4508684 1 NC_011601.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4508684 nusG 7065355 nusG Escherichia coli O127:H6 str. E2348/69 transcription antitermination protein NusG YP_002331745.1 4508139 D 574521 CDS YP_002331746.1 215489315 7062870 4508843..4509271 1 NC_011601.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4509271 rplK 7062870 rplK Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L11 YP_002331746.1 4508843 D 574521 CDS YP_002331747.1 215489316 7061838 4509275..4509979 1 NC_011601.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4509979 rplA 7061838 rplA Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L1 YP_002331747.1 4509275 D 574521 CDS YP_002331748.1 215489317 7061830 4510271..4510768 1 NC_011601.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4510768 rplJ 7061830 rplJ Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L10 YP_002331748.1 4510271 D 574521 CDS YP_002331749.1 215489318 7061837 4510835..4511200 1 NC_011601.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4511200 rplL 7061837 rplL Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L7/L12 YP_002331749.1 4510835 D 574521 CDS YP_002331750.1 215489319 7061158 4511520..4515548 1 NC_011601.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4515548 rpoB 7061158 rpoB Escherichia coli O127:H6 str. E2348/69 DNA-directed RNA polymerase subunit beta YP_002331750.1 4511520 D 574521 CDS YP_002331751.1 215489320 7061864 4515625..4519848 1 NC_011601.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4519848 rpoC 7061864 rpoC Escherichia coli O127:H6 str. E2348/69 DNA-directed RNA polymerase subunit beta' YP_002331751.1 4515625 D 574521 CDS YP_002331752.1 215489321 7061865 complement(4520090..4521223) 1 NC_011601.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 4521223 thiH 7061865 thiH Escherichia coli O127:H6 str. E2348/69 thiamine biosynthesis protein ThiH YP_002331752.1 4520090 R 574521 CDS YP_002331753.1 215489322 7061785 complement(4521220..4521990) 1 NC_011601.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 4521990 thiG 7061785 thiG Escherichia coli O127:H6 str. E2348/69 thiazole synthase YP_002331753.1 4521220 R 574521 CDS YP_002331754.1 215489323 7061784 complement(4521992..4522192) 1 NC_011601.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 4522192 thiS 7061784 thiS Escherichia coli O127:H6 str. E2348/69 sulfur carrier protein ThiS YP_002331754.1 4521992 R 574521 CDS YP_002331755.1 215489324 7061792 complement(4522176..4522931) 1 NC_011601.1 thiamin (thiazole moiety) biosynthesis protein ThiF 4522931 thiF 7061792 thiF Escherichia coli O127:H6 str. E2348/69 thiamin (thiazole moiety) biosynthesis protein ThiF YP_002331755.1 4522176 R 574521 CDS YP_002331756.1 215489325 7061783 complement(4522924..4523559) 1 NC_011601.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 4523559 thiE 7061783 thiE Escherichia coli O127:H6 str. E2348/69 thiamine-phosphate pyrophosphorylase YP_002331756.1 4522924 R 574521 CDS YP_002331757.1 215489326 7061782 complement(4523559..4525454) 1 NC_011601.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 4525454 thiC 7061782 thiC Escherichia coli O127:H6 str. E2348/69 thiamine biosynthesis protein ThiC YP_002331757.1 4523559 R 574521 CDS YP_002331758.1 215489327 7061159 complement(4525687..4526163) 1 NC_011601.1 binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 4526163 rsd 7061159 rsd Escherichia coli O127:H6 str. E2348/69 anti-RNA polymerase sigma 70 factor YP_002331758.1 4525687 R 574521 CDS YP_002331759.1 215489328 7064549 4526258..4527031 1 NC_011601.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4527031 nudC 7064549 nudC Escherichia coli O127:H6 str. E2348/69 NADH pyrophosphatase YP_002331759.1 4526258 D 574521 CDS YP_002331760.1 215489329 7065428 4527071..4528135 1 NC_011601.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4528135 hemE 7065428 hemE Escherichia coli O127:H6 str. E2348/69 uroporphyrinogen decarboxylase YP_002331760.1 4527071 D 574521 CDS YP_002331761.1 215489330 7064295 4528145..4528816 1 NC_011601.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4528816 nfi 7064295 nfi Escherichia coli O127:H6 str. E2348/69 endonuclease V YP_002331761.1 4528145 D 574521 CDS YP_002331762.1 215489331 7065381 4528859..4529449 1 NC_011601.1 hypothetical protein 4529449 yjaG 7065381 yjaG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331762.1 4528859 D 574521 CDS YP_002331763.1 215489332 7064078 4529636..4529908 1 NC_011601.1 histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4529908 hupA 7064078 hupA Escherichia coli O127:H6 str. E2348/69 transcriptional regulator HU subunit alpha YP_002331763.1 4529636 D 574521 CDS YP_002331764.1 215489333 7062193 4529921..4530616 1 NC_011601.1 hypothetical protein 4530616 yjaH 7062193 yjaH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331764.1 4529921 D 574521 CDS YP_002331765.1 215489334 7064079 complement(4530618..4531043) 1 NC_011601.1 zinc resistance protein 4531043 zraP 7064079 zraP Escherichia coli O127:H6 str. E2348/69 zinc resistance protein YP_002331765.1 4530618 R 574521 CDS YP_002331766.1 215489335 7062538 4531281..4532657 1 NC_011601.1 sensor protein ZraS 4532657 zraS 7062538 zraS Escherichia coli O127:H6 str. E2348/69 sensor protein ZraS YP_002331766.1 4531281 D 574521 CDS YP_002331767.1 215489336 7062540 4532654..4533979 1 NC_011601.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4533979 zraR 7062540 zraR Escherichia coli O127:H6 str. E2348/69 transcriptional regulatory protein ZraR YP_002331767.1 4532654 D 574521 CDS YP_002331768.1 215489337 7062539 complement(4533976..4535265) 1 NC_011601.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 4535265 purD 7062539 purD Escherichia coli O127:H6 str. E2348/69 phosphoribosylamine--glycine ligase YP_002331768.1 4533976 R 574521 CDS YP_002331769.1 215489338 7063914 complement(4535277..4536866) 1 NC_011601.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 4536866 purH 7063914 purH Escherichia coli O127:H6 str. E2348/69 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_002331769.1 4535277 R 574521 CDS YP_002331770.1 215489339 7064529 4542667..4543050 1 NC_011601.1 hypothetical protein 4543050 yjaA 7064529 yjaA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331770.1 4542667 D 574521 CDS YP_002331771.1 215489340 7064076 complement(4543114..4543557) 1 NC_011601.1 hypothetical protein 4543557 yjaB 7064076 yjaB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331771.1 4543114 R 574521 CDS YP_002331772.1 215489341 7064077 4543714..4544643 1 NC_011601.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4544643 metA 7064077 metA Escherichia coli O127:H6 str. E2348/69 homoserine O-succinyltransferase YP_002331772.1 4543714 D 574521 CDS YP_002331773.1 215489342 7063756 4544912..4546513 1 NC_011601.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4546513 aceB 7063756 aceB Escherichia coli O127:H6 str. E2348/69 malate synthase YP_002331773.1 4544912 D 574521 CDS YP_002331774.1 215489343 7062385 4546543..4547847 1 NC_011601.1 isocitrate lyase 4547847 aceA 7062385 aceA Escherichia coli O127:H6 str. E2348/69 isocitrate lyase YP_002331774.1 4546543 D 574521 CDS YP_002331775.1 215489344 7062384 4547972..4549696 1 NC_011601.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase 4549696 aceK 7062384 aceK Escherichia coli O127:H6 str. E2348/69 bifunctional isocitrate dehydrogenase kinase/phosphatase YP_002331775.1 4547972 D 574521 CDS YP_002331776.1 215489345 7062388 complement(4549713..4550537) 1 NC_011601.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; IclR family transcriptional regulator 4550537 iclR 7062388 iclR Escherichia coli O127:H6 str. E2348/69 IclR family transcriptional regulator YP_002331776.1 4549713 R 574521 CDS YP_002331777.1 215489346 7063518 4550737..4554420 1 NC_011601.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4554420 metH 7063518 metH Escherichia coli O127:H6 str. E2348/69 B12-dependent methionine synthase YP_002331777.1 4550737 D 574521 CDS YP_002331778.1 215489347 7063762 4554474..4554800 1 NC_011601.1 hypothetical protein 4554800 7063762 E2348C_4322 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331778.1 4554474 D 574521 CDS YP_002331779.1 215489348 7065120 4554843..4555292 1 NC_011601.1 hypothetical protein 4555292 7065120 E2348C_4323 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331779.1 4554843 D 574521 CDS YP_002331780.1 215489349 7065121 4555463..4557094 1 NC_011601.1 transporter 4557094 yjbB 7065121 yjbB Escherichia coli O127:H6 str. E2348/69 transporter YP_002331780.1 4555463 D 574521 CDS YP_002331781.1 215489350 7061136 4557180..4557701 1 NC_011601.1 transposase Orf1 of IS1397 4557701 7061136 E2348C_4325 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS1397 YP_002331781.1 4557180 D 574521 CDS YP_002331782.1 215489351 7061137 4558522..4559598 1 NC_011601.1 transposase of ISEc21 4559598 7061137 E2348C_4327 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc21 YP_002331782.1 4558522 D 574521 CDS YP_002331783.1 215489352 7065123 complement(4559990..4560679) 1 NC_011601.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 4560679 pepE 7065123 pepE Escherichia coli O127:H6 str. E2348/69 peptidase E YP_002331783.1 4559990 R 574521 CDS YP_002331784.1 215489353 7060701 complement(4561060..4562289) 1 NC_011601.1 L-sorbose 1-phosphate dehydrogenase 4562289 7060701 E2348C_4330 Escherichia coli O127:H6 str. E2348/69 L-sorbose 1-phosphate dehydrogenase YP_002331784.1 4561060 R 574521 CDS YP_002331785.1 215489354 7065124 complement(4562341..4563165) 1 NC_011601.1 sorbose-permease PTS system IID component 4563165 7065124 E2348C_4331 Escherichia coli O127:H6 str. E2348/69 sorbose-permease PTS system IID component YP_002331785.1 4562341 R 574521 CDS YP_002331786.1 215489355 7065125 complement(4563176..4563973) 1 NC_011601.1 sorbose-permease PTS system IIC component 4563973 7065125 E2348C_4332 Escherichia coli O127:H6 str. E2348/69 sorbose-permease PTS system IIC component YP_002331786.1 4563176 R 574521 CDS YP_002331787.1 215489356 7065126 complement(4564039..4564533) 1 NC_011601.1 sorbose-permease PTS system IIB component 4564533 7065126 E2348C_4333 Escherichia coli O127:H6 str. E2348/69 sorbose-permease PTS system IIB component YP_002331787.1 4564039 R 574521 CDS YP_002331788.1 215489357 7065127 complement(4564533..4564940) 1 NC_011601.1 sorbose-permease PTS system IIA component 4564940 7065127 E2348C_4334 Escherichia coli O127:H6 str. E2348/69 sorbose-permease PTS system IIA component YP_002331788.1 4564533 R 574521 CDS YP_002331789.1 215489358 7065128 complement(4564950..4565756) 1 NC_011601.1 Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase 4565756 7065128 E2348C_4335 Escherichia coli O127:H6 str. E2348/69 sorbitol-6-phosphate 2-dehydrogenase YP_002331789.1 4564950 R 574521 CDS YP_002331790.1 215489359 7065129 complement(4565826..4566773) 1 NC_011601.1 sor-operon regulator 4566773 7065129 E2348C_4336 Escherichia coli O127:H6 str. E2348/69 sor-operon regulator YP_002331790.1 4565826 R 574521 CDS YP_002331791.1 215489360 7065130 4567121..4567993 1 NC_011601.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4567993 rluF 7065130 rluF Escherichia coli O127:H6 str. E2348/69 23S rRNA pseudouridine synthase F YP_002331791.1 4567121 D 574521 CDS YP_002331792.1 215489361 7060843 complement(4567994..4568266) 1 NC_011601.1 hypothetical protein 4568266 pagB 7060843 pagB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331792.1 4567994 R 574521 CDS YP_002331793.1 215489362 7062903 complement(4568520..4569869) 1 NC_011601.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase 4569869 lysC 7062903 lysC Escherichia coli O127:H6 str. E2348/69 aspartate kinase YP_002331793.1 4568520 R 574521 CDS YP_002331794.1 215489363 7061160 4570394..4572043 1 NC_011601.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4572043 pgi 7061160 pgi Escherichia coli O127:H6 str. E2348/69 glucose-6-phosphate isomerase YP_002331794.1 4570394 D 574521 CDS YP_002331795.1 215489364 7060713 4572397..4572639 1 NC_011601.1 hypothetical protein 4572639 yjbE 7060713 yjbE Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331795.1 4572397 D 574521 CDS YP_002331796.1 215489365 7064080 4572753..4573391 1 NC_011601.1 lipoprotein 4573391 yjbF 7064080 yjbF Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002331796.1 4572753 D 574521 CDS YP_002331797.1 215489366 7064081 4573388..4574125 1 NC_011601.1 hypothetical protein 4574125 yjbG 7064081 yjbG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331797.1 4573388 D 574521 CDS YP_002331798.1 215489367 7064082 4574125..4576221 1 NC_011601.1 porin 4576221 yjbH 7064082 yjbH Escherichia coli O127:H6 str. E2348/69 porin YP_002331798.1 4574125 D 574521 CDS YP_002331799.1 215489368 7064083 complement(4576268..4576546) 1 NC_011601.1 hypothetical protein 4576546 yjbT 7064083 yjbT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331799.1 4576268 R 574521 CDS YP_002331800.1 215489369 7064087 4576761..4577171 1 NC_011601.1 phosphate-starvation-inducible protein PsiE 4577171 psiE 7064087 psiE Escherichia coli O127:H6 str. E2348/69 phosphate-starvation-inducible protein PsiE YP_002331800.1 4576761 D 574521 CDS YP_002331801.1 215489370 7061316 complement(4577265..4578155) 1 NC_011601.1 with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease 4578155 malG 7061316 malG Escherichia coli O127:H6 str. E2348/69 maltose transporter permease YP_002331801.1 4577265 R 574521 CDS YP_002331802.1 215489371 7065272 complement(4578170..4579714) 1 NC_011601.1 with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 4579714 malF 7065272 malF Escherichia coli O127:H6 str. E2348/69 maltose transporter membrane protein YP_002331802.1 4578170 R 574521 CDS YP_002331803.1 215489372 7065271 complement(4579868..4581058) 1 NC_011601.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein 4581058 malE 7065271 malE Escherichia coli O127:H6 str. E2348/69 maltose ABC transporter periplasmic protein YP_002331803.1 4579868 R 574521 CDS YP_002331804.1 215489373 7065270 4581423..4582538 1 NC_011601.1 with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 4582538 malK 7065270 malK Escherichia coli O127:H6 str. E2348/69 maltose/maltodextrin transporter ATP-binding protein YP_002331804.1 4581423 D 574521 CDS YP_002331805.1 215489374 7065274 4582610..4583950 1 NC_011601.1 porin involved in the transport of maltose and maltodextrins; maltoporin 4583950 lamB 7065274 lamB Escherichia coli O127:H6 str. E2348/69 maltoporin YP_002331805.1 4582610 D 574521 CDS YP_002331806.1 215489375 7061139 complement(4584135..4585508) 1 NC_011601.1 transposase of ISEc13 4585508 7061139 E2348C_4352 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002331806.1 4584135 R 574521 CDS YP_002331807.1 215489376 7065131 4585740..4586675 1 NC_011601.1 maltose regulon periplasmic protein 4586675 malM 7065131 malM Escherichia coli O127:H6 str. E2348/69 maltose regulon periplasmic protein YP_002331807.1 4585740 D 574521 CDS YP_002331808.1 215489377 7065275 4586854..4587351 1 NC_011601.1 catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4587351 ubiC 7065275 ubiC Escherichia coli O127:H6 str. E2348/69 chorismate pyruvate lyase YP_002331808.1 4586854 D 574521 CDS YP_002331809.1 215489378 7062292 4587364..4588236 1 NC_011601.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4588236 ubiA 7062292 ubiA Escherichia coli O127:H6 str. E2348/69 4-hydroxybenzoate octaprenyltransferase YP_002331809.1 4587364 D 574521 CDS YP_002331810.1 215489379 7062290 complement(4588391..4590814) 1 NC_011601.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 4590814 plsB 7062290 plsB Escherichia coli O127:H6 str. E2348/69 glycerol-3-phosphate acyltransferase YP_002331810.1 4588391 R 574521 CDS YP_002331811.1 215489380 7060756 4590985..4591353 1 NC_011601.1 diacylglycerol kinase 4591353 dgkA 7060756 dgkA Escherichia coli O127:H6 str. E2348/69 diacylglycerol kinase YP_002331811.1 4590985 D 574521 CDS YP_002331812.1 215489381 7065014 4591463..4592071 1 NC_011601.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 4592071 lexA 7065014 lexA Escherichia coli O127:H6 str. E2348/69 LexA repressor YP_002331812.1 4591463 D 574521 CDS YP_002331813.1 215489382 7061537 4592090..4593469 1 NC_011601.1 DNA-damage-inducible SOS response protein 4593469 dinF 7061537 dinF Escherichia coli O127:H6 str. E2348/69 DNA-damage-inducible SOS response protein YP_002331813.1 4592090 D 574521 CDS YP_002331814.1 215489383 7065030 4593585..4593794 1 NC_011601.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein 4593794 yjbJ 7065030 yjbJ Escherichia coli O127:H6 str. E2348/69 stress-response protein YP_002331814.1 4593585 D 574521 CDS YP_002331815.1 215489384 7064084 complement(4593836..4594351) 1 NC_011601.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor 4594351 zur 7064084 zur Escherichia coli O127:H6 str. E2348/69 zinc uptake transcriptional repressor YP_002331815.1 4593836 R 574521 CDS YP_002331816.1 215489385 7062542 4594507..4595502 1 NC_011601.1 tRNA-dihydrouridine synthase A 4595502 dusA 7062542 dusA Escherichia coli O127:H6 str. E2348/69 tRNA-dihydrouridine synthase A YP_002331816.1 4594507 D 574521 CDS YP_002331817.1 215489386 7065071 4595636..4595878 1 NC_011601.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4595878 pspG 7065071 pspG Escherichia coli O127:H6 str. E2348/69 phage shock protein G YP_002331817.1 4595636 D 574521 CDS YP_002331818.1 215489387 7063938 4597114..4598529 1 NC_011601.1 unwinds double stranded DNA; replicative DNA helicase 4598529 dnaB 7063938 dnaB Escherichia coli O127:H6 str. E2348/69 replicative DNA helicase YP_002331818.1 4597114 D 574521 CDS YP_002331819.1 215489388 7065045 4598582..4599661 1 NC_011601.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4599661 alr 7065045 alr Escherichia coli O127:H6 str. E2348/69 alanine racemase YP_002331819.1 4598582 D 574521 CDS YP_002331820.1 215489389 7062445 4599684..4600241 1 NC_011601.1 nicotinamide mononucleotide transporter 4600241 7062445 E2348C_4367 Escherichia coli O127:H6 str. E2348/69 nicotinamide mononucleotide transporter YP_002331820.1 4599684 D 574521 CDS YP_002331821.1 215489390 7065132 4600238..4601242 1 NC_011601.1 NadR-like protein 4601242 7065132 E2348C_4368 Escherichia coli O127:H6 str. E2348/69 NadR-like protein YP_002331821.1 4600238 D 574521 CDS YP_002331822.1 215489391 7065133 4601324..4602517 1 NC_011601.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4602517 tyrB 7065133 tyrB Escherichia coli O127:H6 str. E2348/69 aromatic amino acid aminotransferase YP_002331822.1 4601324 D 574521 CDS YP_002331823.1 215489392 7062284 4602699..4605443 1 NC_011601.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 4605443 sucA 7062284 sucA Escherichia coli O127:H6 str. E2348/69 2-oxoglutarate dehydrogenase E1 YP_002331823.1 4602699 D 574521 CDS YP_002331824.1 215489393 7065134 4605476..4606630 1 NC_011601.1 dihydrolipoyltranssuccinase 4606630 7065134 E2348C_4371 Escherichia coli O127:H6 str. E2348/69 dihydrolipoyltranssuccinase YP_002331824.1 4605476 D 574521 CDS YP_002331825.1 215489394 7065135 4606642..4608060 1 NC_011601.1 dihydrolipoamide dehydrogenase 4608060 7065135 E2348C_4372 Escherichia coli O127:H6 str. E2348/69 dihydrolipoamide dehydrogenase YP_002331825.1 4606642 D 574521 CDS YP_002331826.1 215489395 7065136 4608082..4609251 1 NC_011601.1 succinyl-CoA synthetase, beta subunit 4609251 7065136 E2348C_4373 Escherichia coli O127:H6 str. E2348/69 succinyl-CoA synthetase, beta subunit YP_002331826.1 4608082 D 574521 CDS YP_002331827.1 215489396 7065137 4609264..4610136 1 NC_011601.1 succinyl-CoA synthetase subunit alpha 4610136 7065137 E2348C_4374 Escherichia coli O127:H6 str. E2348/69 succinyl-CoA synthetase subunit alpha YP_002331827.1 4609264 D 574521 CDS YP_002331828.1 215489397 7065138 4610348..4611847 1 NC_011601.1 di-and tricarboxylate transporter 4611847 7065138 E2348C_4375 Escherichia coli O127:H6 str. E2348/69 di-and tricarboxylate transporter YP_002331828.1 4610348 D 574521 CDS YP_002331829.1 215489398 7065139 4611859..4612932 1 NC_011601.1 dehydrogenase 4612932 7065139 E2348C_4376 Escherichia coli O127:H6 str. E2348/69 dehydrogenase YP_002331829.1 4611859 D 574521 CDS YP_002331830.1 215489399 7065140 complement(4612921..4614279) 1 NC_011601.1 response regulator in two-component system 4614279 7065140 E2348C_4377 Escherichia coli O127:H6 str. E2348/69 response regulator in two-component system YP_002331830.1 4612921 R 574521 CDS YP_002331831.1 215489400 7065141 complement(4614272..4616092) 1 NC_011601.1 sensory histidine kinase in two-component system 4616092 7065141 E2348C_4378 Escherichia coli O127:H6 str. E2348/69 sensory histidine kinase in two-component system YP_002331831.1 4614272 R 574521 CDS YP_002331832.1 215489401 7065142 4616369..4617082 1 NC_011601.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4617082 aphA 7065142 aphA Escherichia coli O127:H6 str. E2348/69 acid phosphatase/phosphotransferase YP_002331832.1 4616369 D 574521 CDS YP_002331833.1 215489402 7061350 4617193..4617609 1 NC_011601.1 hypothetical protein 4617609 yjbQ 7061350 yjbQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331833.1 4617193 D 574521 CDS YP_002331834.1 215489403 7064085 4617613..4617969 1 NC_011601.1 hypothetical protein 4617969 yjbR 7064085 yjbR Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331834.1 4617613 D 574521 CDS YP_002331835.1 215489404 7064086 complement(4618004..4620826) 1 NC_011601.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 4620826 uvrA 7064086 uvrA Escherichia coli O127:H6 str. E2348/69 excinuclease ABC subunit A YP_002331835.1 4618004 R 574521 CDS YP_002331836.1 215489405 7062340 4621081..4621617 1 NC_011601.1 binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4621617 ssb 7062340 ssb Escherichia coli O127:H6 str. E2348/69 single-stranded DNA-binding protein YP_002331836.1 4621081 D 574521 CDS YP_002331837.1 215489406 7062760 complement(4621716..4621997) 1 NC_011601.1 hypothetical protein 4621997 yjcB 7062760 yjcB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331837.1 4621716 R 574521 CDS YP_002331838.1 215489407 7064088 4622426..4623979 1 NC_011601.1 signal transduction protein (EAL domain containing protein) 4623979 yjcC 7064088 yjcC Escherichia coli O127:H6 str. E2348/69 signal transduction protein (EAL domain containing protein) YP_002331838.1 4622426 D 574521 CDS YP_002331839.1 215489408 7064089 complement(4624015..4624338) 1 NC_011601.1 regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 4624338 soxS 7064089 soxS Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator SoxS YP_002331839.1 4624015 R 574521 CDS YP_002331840.1 215489409 7062739 4624424..4624888 1 NC_011601.1 DNA-binding transcriptional dual regulator, Fe-Scenter for redox-sensing 4624888 soxR 7062739 soxR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional dual regulator, Fe-Scenter for redox-sensing YP_002331840.1 4624424 D 574521 CDS YP_002331841.1 215489410 7065325 4625435..4626784 1 NC_011601.1 permease 4626784 yjcD 7065325 yjcD Escherichia coli O127:H6 str. E2348/69 permease YP_002331841.1 4625435 D 574521 CDS YP_002331842.1 215489411 7064090 4626935..4628584 1 NC_011601.1 cation/proton antiporter 4628584 yjcE 7064090 yjcE Escherichia coli O127:H6 str. E2348/69 cation/proton antiporter YP_002331842.1 4626935 D 574521 CDS YP_002331843.1 215489412 7064091 complement(4628667..4630316) 1 NC_011601.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease 4630316 actP 7064091 actP Escherichia coli O127:H6 str. E2348/69 acetate permease YP_002331843.1 4628667 R 574521 CDS YP_002331844.1 215489413 7062403 complement(4630313..4630627) 1 NC_011601.1 inner membrane protein involved in acetate transport 4630627 yjcH 7062403 yjcH Escherichia coli O127:H6 str. E2348/69 inner membrane protein involved in acetate transport YP_002331844.1 4630313 R 574521 CDS YP_002331845.1 215489414 7064092 complement(4630919..4632877) 1 NC_011601.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4632877 acs 7064092 acs Escherichia coli O127:H6 str. E2348/69 acetyl-CoA synthetase YP_002331845.1 4630919 R 574521 CDS YP_002331846.1 215489415 7062402 4633269..4634705 1 NC_011601.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4634705 nrfA 7062402 nrfA Escherichia coli O127:H6 str. E2348/69 cytochrome c552 YP_002331846.1 4633269 D 574521 CDS YP_002331847.1 215489416 7065418 4634750..4635316 1 NC_011601.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4635316 nrfB 7065418 nrfB Escherichia coli O127:H6 str. E2348/69 cytochrome c nitrite reductase pentaheme subunit YP_002331847.1 4634750 D 574521 CDS YP_002331848.1 215489417 7065419 4635313..4635984 1 NC_011601.1 formate-dependent nitrite reductase NrfC, 4Fe4S subunit 4635984 nrfC 7065419 nrfC Escherichia coli O127:H6 str. E2348/69 formate-dependent nitrite reductase NrfC, 4Fe4S subunit YP_002331848.1 4635313 D 574521 CDS YP_002331849.1 215489418 7065420 4635981..4636937 1 NC_011601.1 formate-dependent nitrite reductase complex subunit NrfD 4636937 nrfD 7065420 nrfD Escherichia coli O127:H6 str. E2348/69 formate-dependent nitrite reductase complex subunit NrfD YP_002331849.1 4635981 D 574521 CDS YP_002331850.1 215489419 7065421 4637017..4638675 1 NC_011601.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4638675 nrfE 7065421 nrfE Escherichia coli O127:H6 str. E2348/69 heme lyase subunit NrfE YP_002331850.1 4637017 D 574521 CDS YP_002331851.1 215489420 7065422 4638668..4639051 1 NC_011601.1 formate-dependent nitrite reductase complex subunit NrfF 4639051 nrfF 7065422 nrfF Escherichia coli O127:H6 str. E2348/69 formate-dependent nitrite reductase complex subunit NrfF YP_002331851.1 4638668 D 574521 CDS YP_002331852.1 215489421 7065423 4639048..4639644 1 NC_011601.1 formate-dependent nitrite reductase complex subunit NrfG 4639644 nrfG 7065423 nrfG Escherichia coli O127:H6 str. E2348/69 formate-dependent nitrite reductase complex subunit NrfG YP_002331852.1 4639048 D 574521 CDS YP_002331853.1 215489422 7065424 4639987..4641300 1 NC_011601.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4641300 gltP 7065424 gltP Escherichia coli O127:H6 str. E2348/69 glutamate/aspartate:proton symporter YP_002331853.1 4639987 D 574521 CDS YP_002331854.1 215489423 7061711 complement(4641378..4642067) 1 NC_011601.1 hypothetical protein 4642067 yjcO 7061711 yjcO Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331854.1 4641378 R 574521 CDS YP_002331855.1 215489424 7064093 complement(4642178..4642882) 1 NC_011601.1 ABC transporter ATP-binding protein 4642882 7064093 E2348C_4402 Escherichia coli O127:H6 str. E2348/69 ABC transporter ATP-binding protein YP_002331855.1 4642178 R 574521 CDS YP_002331856.1 215489425 7065143 complement(4642869..4643705) 1 NC_011601.1 ABC transporter ATP-binding protein 4643705 7065143 E2348C_4403 Escherichia coli O127:H6 str. E2348/69 ABC transporter ATP-binding protein YP_002331856.1 4642869 R 574521 CDS YP_002331857.1 215489426 7065144 complement(4643698..4644531) 1 NC_011601.1 ABC transporter permease 4644531 7065144 E2348C_4404 Escherichia coli O127:H6 str. E2348/69 ABC transporter permease YP_002331857.1 4643698 R 574521 CDS YP_002331858.1 215489427 7065145 complement(4644531..4645580) 1 NC_011601.1 ABC transporter permease 4645580 7065145 E2348C_4405 Escherichia coli O127:H6 str. E2348/69 ABC transporter permease YP_002331858.1 4644531 R 574521 CDS YP_002331859.1 215489428 7065146 complement(4645680..4647248) 1 NC_011601.1 dipeptide ABC transporter periplasmic protein 4647248 7065146 E2348C_4406 Escherichia coli O127:H6 str. E2348/69 dipeptide ABC transporter periplasmic protein YP_002331859.1 4645680 R 574521 CDS YP_002331860.1 215489429 7065147 complement(4647623..4649770) 1 NC_011601.1 selenocysteine (Sec=>U); formate dehydrogenase-H, selenopolypeptide subunit 4649770 fdhF 7065147 fdhF Escherichia coli O127:H6 str. E2348/69 formate dehydrogenase-H, selenopolypeptide subunit YP_002331860.1 4647623 R 574521 CDS YP_002331861.1 215489430 7062087 complement(4649968..4651434) 1 NC_011601.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; outer membrane efflux protein MdtP 4651434 mdtP 7062087 mdtP Escherichia coli O127:H6 str. E2348/69 outer membrane efflux protein MdtP YP_002331861.1 4649968 R 574521 CDS YP_002331862.1 215489431 7065320 complement(4651431..4653482) 1 NC_011601.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO 4653482 mdtO 7065320 mdtO Escherichia coli O127:H6 str. E2348/69 multidrug efflux system protein MdtO YP_002331862.1 4651431 R 574521 CDS YP_002331863.1 215489432 7065319 complement(4653482..4654513) 1 NC_011601.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN 4654513 mdtN 7065319 mdtN Escherichia coli O127:H6 str. E2348/69 multidrug resistance protein MdtN YP_002331863.1 4653482 R 574521 CDS YP_002331864.1 215489433 7065318 complement(4654532..4654807) 1 NC_011601.1 hypothetical protein 4654807 ytcA 7065318 ytcA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331864.1 4654532 R 574521 CDS YP_002331865.1 215489434 7063239 complement(4655016..4657001) 1 NC_011601.1 alkyl sulfatase 4657001 yjcS 7063239 yjcS Escherichia coli O127:H6 str. E2348/69 alkyl sulfatase YP_002331865.1 4655016 R 574521 CDS YP_002331866.1 215489435 7064094 complement(4657274..4658203) 1 NC_011601.1 D-allose kinase 4658203 alsK 7064094 alsK Escherichia coli O127:H6 str. E2348/69 D-allose kinase YP_002331866.1 4657274 R 574521 CDS YP_002331867.1 215489436 7062450 complement(4658187..4658882) 1 NC_011601.1 allulose-6-phosphate 3-epimerase 4658882 alsE 7062450 alsE Escherichia coli O127:H6 str. E2348/69 allulose-6-phosphate 3-epimerase YP_002331867.1 4658187 R 574521 CDS YP_002331868.1 215489437 7062449 complement(4658893..4659873) 1 NC_011601.1 D-allose transporter subunit 4659873 alsC 7062449 alsC Escherichia coli O127:H6 str. E2348/69 D-allose transporter subunit YP_002331868.1 4658893 R 574521 CDS YP_002331869.1 215489438 7062448 complement(4659852..4661384) 1 NC_011601.1 with AlsBC acts to import allose into the cell; AlsA contain 2 ATP-binding domains; D-allose transporter ATP-binding protein 4661384 alsA 7062448 alsA Escherichia coli O127:H6 str. E2348/69 D-allose transporter ATP-binding protein YP_002331869.1 4659852 R 574521 CDS YP_002331870.1 215489439 7062446 complement(4661512..4662447) 1 NC_011601.1 D-allose transporter subunit 4662447 alsB 7062446 alsB Escherichia coli O127:H6 str. E2348/69 D-allose transporter subunit YP_002331870.1 4661512 R 574521 CDS YP_002331871.1 215489440 7062447 complement(4662506..4663396) 1 NC_011601.1 involved in rpiB and als operon repression; DNA-binding transcriptional repressor RpiR 4663396 rpiR 7062447 rpiR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor RpiR YP_002331871.1 4662506 R 574521 CDS YP_002331872.1 215489441 7061829 4663750..4664199 1 NC_011601.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 4664199 rpiB 7061829 rpiB Escherichia coli O127:H6 str. E2348/69 ribose-5-phosphate isomerase B YP_002331872.1 4663750 D 574521 CDS YP_002331873.1 215489442 7061828 4664268..4664597 1 NC_011601.1 hypothetical protein 4664597 yjdP 7061828 yjdP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331873.1 4664268 D 574521 CDS YP_002331874.1 215489443 7064104 complement(4664632..4665390) 1 NC_011601.1 required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein 4665390 phnP 7064104 phnP Escherichia coli O127:H6 str. E2348/69 carbon-phosphorus lyase complex accessory protein YP_002331874.1 4664632 R 574521 CDS YP_002331875.1 215489444 7060741 complement(4665392..4665826) 1 NC_011601.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase 4665826 phnO 7060741 phnO Escherichia coli O127:H6 str. E2348/69 aminoalkylphosphonic acid N-acetyltransferase YP_002331875.1 4665392 R 574521 CDS YP_002331876.1 215489445 7060740 complement(4665813..4666370) 1 NC_011601.1 ribose 1,5-bisphosphokinase 4666370 phnN 7060740 phnN Escherichia coli O127:H6 str. E2348/69 ribose 1,5-bisphosphokinase YP_002331876.1 4665813 R 574521 CDS YP_002331877.1 215489446 7060739 complement(4666370..4667506) 1 NC_011601.1 carbon-phosphorus lyase complex subunit PhnM 4667506 phnM 7060739 phnM Escherichia coli O127:H6 str. E2348/69 carbon-phosphorus lyase complex subunit PhnM YP_002331877.1 4666370 R 574521 CDS YP_002331878.1 215489447 7060738 complement(4667503..4668183) 1 NC_011601.1 carbon-phosphorus lyase complex subunit PhnL 4668183 phnL 7060738 phnL Escherichia coli O127:H6 str. E2348/69 carbon-phosphorus lyase complex subunit PhnL YP_002331878.1 4667503 R 574521 CDS YP_002331879.1 215489448 7060737 complement(4668294..4669052) 1 NC_011601.1 phosphonate C-P lyase system protein PhnK 4669052 phnK 7060737 phnK Escherichia coli O127:H6 str. E2348/69 phosphonate C-P lyase system protein PhnK YP_002331879.1 4668294 R 574521 CDS YP_002331880.1 215489449 7060736 complement(4669049..4669894) 1 NC_011601.1 carbon-phosphorus lyase complex subunit PhnJ 4669894 phnJ 7060736 phnJ Escherichia coli O127:H6 str. E2348/69 carbon-phosphorus lyase complex subunit PhnJ YP_002331880.1 4669049 R 574521 CDS YP_002331881.1 215489450 7060735 complement(4669887..4670951) 1 NC_011601.1 carbon-phosphorus lyase complex subunit PhnI 4670951 phnI 7060735 phnI Escherichia coli O127:H6 str. E2348/69 carbon-phosphorus lyase complex subunit PhnI YP_002331881.1 4669887 R 574521 CDS YP_002331882.1 215489451 7060734 complement(4670951..4671535) 1 NC_011601.1 carbon-phosphorus lyase complex subunit 4671535 phnH 7060734 phnH Escherichia coli O127:H6 str. E2348/69 carbon-phosphorus lyase complex subunit YP_002331882.1 4670951 R 574521 CDS YP_002331883.1 215489452 7060733 complement(4671532..4671984) 1 NC_011601.1 carbon-phosphorus lyase complex subunit PhnG 4671984 phnG 7060733 phnG Escherichia coli O127:H6 str. E2348/69 carbon-phosphorus lyase complex subunit PhnG YP_002331883.1 4671532 R 574521 CDS YP_002331884.1 215489453 7060732 complement(4671985..4672710) 1 NC_011601.1 may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF 4672710 phnF 7060732 phnF Escherichia coli O127:H6 str. E2348/69 phosphonate metabolism transcriptional regulator PhnF YP_002331884.1 4671985 R 574521 CDS YP_002331885.1 215489454 7060731 complement(4672731..4673564) 1 NC_011601.1 phosphonate/organophosphate ester transporter subunit PhnE, membrane component of ABC superfamily 4673564 phnE 7060731 phnE Escherichia coli O127:H6 str. E2348/69 phosphonate/organophosphate ester transporter subunit PhnE, membrane component of ABC superfamily YP_002331885.1 4672731 R 574521 CDS YP_002331886.1 215489455 7060730 complement(4673616..4674632) 1 NC_011601.1 phosphonate/organophosphate ester transporter subunit 4674632 phnD 7060730 phnD Escherichia coli O127:H6 str. E2348/69 phosphonate/organophosphate ester transporter subunit YP_002331886.1 4673616 R 574521 CDS YP_002331887.1 215489456 7060729 complement(4674657..4675445) 1 NC_011601.1 phosphonate/organophosphate ester transporter subunit 4675445 phnC 7060729 phnC Escherichia coli O127:H6 str. E2348/69 phosphonate/organophosphate ester transporter subunit YP_002331887.1 4674657 R 574521 CDS YP_002331888.1 215489457 7060728 complement(4675578..4676021) 1 NC_011601.1 hypothetical protein 4676021 yjdN 7060728 yjdN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331888.1 4675578 R 574521 CDS YP_002331889.1 215489458 7064103 complement(4676181..4676516) 1 NC_011601.1 hypothetical protein 4676516 yjdM 7064103 yjdM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331889.1 4676181 R 574521 CDS YP_002331890.1 215489459 7064102 4676919..4679147 1 NC_011601.1 hypothetical protein 4679147 yjdA 7064102 yjdA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331890.1 4676919 D 574521 CDS YP_002331891.1 215489460 7064095 4679144..4680022 1 NC_011601.1 hypothetical protein 4680022 yjdZ 7064095 yjdZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331891.1 4679144 D 574521 CDS YP_002331892.1 215489461 7064105 4680286..4681788 1 NC_011601.1 proline/glycine betaine transporter 4681788 proP 7064105 proP Escherichia coli O127:H6 str. E2348/69 proline/glycine betaine transporter YP_002331892.1 4680286 D 574521 CDS YP_002331893.1 215489462 7061302 complement(4681965..4683056) 1 NC_011601.1 sensor protein BasS/PmrB 4683056 basS 7061302 basS Escherichia coli O127:H6 str. E2348/69 sensor protein BasS/PmrB YP_002331893.1 4681965 R 574521 CDS YP_002331894.1 215489463 7062495 complement(4683066..4683734) 1 NC_011601.1 response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR 4683734 basR 7062495 basR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator BasR YP_002331894.1 4683066 R 574521 CDS YP_002331895.1 215489464 7062494 complement(4683731..4685374) 1 NC_011601.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein 4685374 eptA 7062494 eptA Escherichia coli O127:H6 str. E2348/69 cell division protein YP_002331895.1 4683731 R 574521 CDS YP_002331896.1 215489465 7063863 complement(4685478..4686815) 1 NC_011601.1 arginine:agmatin antiporter 4686815 adiC 7063863 adiC Escherichia coli O127:H6 str. E2348/69 arginine:agmatin antiporter YP_002331896.1 4685478 R 574521 CDS YP_002331897.1 215489466 7062409 complement(4686952..4687713) 1 NC_011601.1 DNA-binding transcriptional activator 4687713 adiY 7062409 adiY Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator YP_002331897.1 4686952 R 574521 CDS YP_002331898.1 215489467 7062410 complement(4688037..4690307) 1 NC_011601.1 biodegradative arginine decarboxylase 4690307 adiA 7062410 adiA Escherichia coli O127:H6 str. E2348/69 biodegradative arginine decarboxylase YP_002331898.1 4688037 R 574521 CDS YP_002331899.1 215489468 7062408 complement(4690503..4691411) 1 NC_011601.1 DNA-binding transcriptional regulator MelR 4691411 melR 7062408 melR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator MelR YP_002331899.1 4690503 R 574521 CDS YP_002331900.1 215489469 7065323 4691694..4693049 1 NC_011601.1 alpha-galactosidase 4693049 melA 7065323 melA Escherichia coli O127:H6 str. E2348/69 alpha-galactosidase YP_002331900.1 4691694 D 574521 CDS YP_002331901.1 215489470 7065322 complement(4693046..4693696) 1 NC_011601.1 hypothetical protein 4693696 yjdF 7065322 yjdF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331901.1 4693046 R 574521 CDS YP_002331902.1 215489471 7064097 complement(4693819..4695465) 1 NC_011601.1 anaerobic class I fumarate hydratase (fumaraseB) 4695465 fumB 7064097 fumB Escherichia coli O127:H6 str. E2348/69 anaerobic class I fumarate hydratase (fumaraseB) YP_002331902.1 4693819 R 574521 CDS YP_002331903.1 215489472 7061601 complement(4695543..4696883) 1 NC_011601.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 4696883 dcuB 7061601 dcuB Escherichia coli O127:H6 str. E2348/69 anaerobic C4-dicarboxylate transporter YP_002331903.1 4695543 R 574521 CDS YP_002331904.1 215489473 7065232 complement(4697454..4698173) 1 NC_011601.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR 4698173 dcuR 7065232 dcuR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator DcuR YP_002331904.1 4697454 R 574521 CDS YP_002331905.1 215489474 7065234 complement(4698170..4699801) 1 NC_011601.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS 4699801 dcuS 7065234 dcuS Escherichia coli O127:H6 str. E2348/69 sensory histidine kinase DcuS YP_002331905.1 4698170 R 574521 CDS YP_002331906.1 215489475 7065235 4699982..4700212 1 NC_011601.1 hypothetical protein 4700212 yjdI 7065235 yjdI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331906.1 4699982 D 574521 CDS YP_002331907.1 215489476 7064098 4700224..4700496 1 NC_011601.1 acyltransferase with acyl-CoAN-acyltransferase domain 4700496 yjdJ 7064098 yjdJ Escherichia coli O127:H6 str. E2348/69 acyltransferase with acyl-CoAN-acyltransferase domain YP_002331907.1 4700224 D 574521 CDS YP_002331908.1 215489477 7064099 4700724..4701020 1 NC_011601.1 hypothetical protein 4701020 yjdK 7064099 yjdK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331908.1 4700724 D 574521 CDS YP_002331909.1 215489478 7064100 complement(4701340..4702857) 1 NC_011601.1 class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 4702857 lysU 7064100 lysU Escherichia coli O127:H6 str. E2348/69 lysyl-tRNA synthetase YP_002331909.1 4701340 R 574521 CDS YP_002331910.1 215489479 7065258 complement(4703094..4704551) 1 NC_011601.1 transporter 4704551 yjdL 7065258 yjdL Escherichia coli O127:H6 str. E2348/69 transporter YP_002331910.1 4703094 R 574521 CDS YP_002331911.1 215489480 7064101 complement(4704610..4706757) 1 NC_011601.1 lysine decarboxylase 1 4706757 cadA 7064101 cadA Escherichia coli O127:H6 str. E2348/69 lysine decarboxylase 1 YP_002331911.1 4704610 R 574521 CDS YP_002331912.1 215489481 7064313 complement(4706837..4708171) 1 NC_011601.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter 4708171 cadB 7064313 cadB Escherichia coli O127:H6 str. E2348/69 lysine/cadaverine antiporter YP_002331912.1 4706837 R 574521 CDS YP_002331913.1 215489482 7060726 complement(4710874..4711449) 1 NC_011601.1 transcriptional regulator 4711449 yjdC 7060726 yjdC Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002331913.1 4710874 R 574521 CDS YP_002331914.1 215489483 7064096 complement(4711486..4713183) 1 NC_011601.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 4713183 dipZ 7064096 dipZ Escherichia coli O127:H6 str. E2348/69 thiol:disulfide interchange protein YP_002331914.1 4711486 R 574521 CDS YP_002331915.1 215489484 7065034 complement(4713159..4713497) 1 NC_011601.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA 4713497 cutA 7065034 cutA Escherichia coli O127:H6 str. E2348/69 divalent-cation tolerance protein CutA YP_002331915.1 4713159 R 574521 CDS YP_002331916.1 215489485 7065175 complement(4713612..4714913) 1 NC_011601.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 4714913 dcuA 7065175 dcuA Escherichia coli O127:H6 str. E2348/69 anaerobic C4-dicarboxylate transporter YP_002331916.1 4713612 R 574521 CDS YP_002331917.1 215489486 7065231 complement(4715031..4716467) 1 NC_011601.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 4716467 aspA 7065231 aspA Escherichia coli O127:H6 str. E2348/69 aspartate ammonia-lyase YP_002331917.1 4715031 R 574521 CDS YP_002331918.1 215489487 7063343 4716804..4717280 1 NC_011601.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 4717280 fxsA 7063343 fxsA Escherichia coli O127:H6 str. E2348/69 FxsA protein YP_002331918.1 4716804 D 574521 CDS YP_002331919.1 215489488 7061605 complement(4717296..4718552) 1 NC_011601.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function; hypothetical protein 4718552 yjeH 7061605 yjeH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331919.1 4717296 R 574521 CDS YP_002331920.1 215489489 7064108 4718828..4719121 1 NC_011601.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4719121 groES 7064108 groES Escherichia coli O127:H6 str. E2348/69 co-chaperonin GroES YP_002331920.1 4718828 D 574521 CDS YP_002331921.1 215489490 7064244 4719165..4720811 1 NC_011601.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 4720811 groEL 7064244 groEL Escherichia coli O127:H6 str. E2348/69 molecular chaperone GroEL YP_002331921.1 4719165 D 574521 CDS YP_002331922.1 215489491 7064243 4720949..4721302 1 NC_011601.1 hypothetical protein 4721302 yjeI 7064243 yjeI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331922.1 4720949 D 574521 CDS YP_002331923.1 215489492 7064109 complement(4721352..4722221) 1 NC_011601.1 hypothetical protein 4722221 yjeJ 7064109 yjeJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331923.1 4721352 R 574521 CDS YP_002331924.1 215489493 7064110 complement(4722456..4723484) 1 NC_011601.1 lysine aminomutase 4723484 yjeK 7064110 yjeK Escherichia coli O127:H6 str. E2348/69 lysine aminomutase YP_002331924.1 4722456 R 574521 CDS YP_002331925.1 215489494 7064111 4723526..4724092 1 NC_011601.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4724092 efp 7064111 efp Escherichia coli O127:H6 str. E2348/69 elongation factor P YP_002331925.1 4723526 D 574521 CDS YP_002331926.1 215489495 7063840 4724144..4724269 1 NC_011601.1 acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 4724269 ecnA 7063840 ecnA Escherichia coli O127:H6 str. E2348/69 entericidin A YP_002331926.1 4724144 D 574521 CDS YP_002331927.1 215489496 7065083 4724380..4724526 1 NC_011601.1 entericidin B 4724526 ecnB 7065083 ecnB Escherichia coli O127:H6 str. E2348/69 entericidin B YP_002331927.1 4724380 D 574521 CDS YP_002331928.1 215489497 7063749 4724702..4725019 1 NC_011601.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 4725019 sugE 7063749 sugE Escherichia coli O127:H6 str. E2348/69 quaternary ammonium compound-resistance protein SugE YP_002331928.1 4724702 D 574521 CDS YP_002331929.1 215489498 7061741 complement(4725016..4725549) 1 NC_011601.1 lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 4725549 blc 7061741 blc Escherichia coli O127:H6 str. E2348/69 outer membrane lipoprotein Blc YP_002331929.1 4725016 R 574521 CDS YP_002331930.1 215489499 7062528 complement(4725638..4726771) 1 NC_011601.1 beta-lactamase 4726771 ampC 7062528 ampC Escherichia coli O127:H6 str. E2348/69 beta-lactamase YP_002331930.1 4725638 R 574521 CDS YP_002331931.1 215489500 7062456 complement(4726834..4727193) 1 NC_011601.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 4727193 frdD 7062456 frdD Escherichia coli O127:H6 str. E2348/69 fumarate reductase subunit D YP_002331931.1 4726834 R 574521 CDS YP_002331932.1 215489501 7061952 complement(4727204..4727599) 1 NC_011601.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 4727599 frdC 7061952 frdC Escherichia coli O127:H6 str. E2348/69 fumarate reductase subunit C YP_002331932.1 4727204 R 574521 CDS YP_002331933.1 215489502 7061951 complement(4727610..4728344) 1 NC_011601.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 4728344 frdB 7061951 frdB Escherichia coli O127:H6 str. E2348/69 fumarate reductase iron-sulfur subunit YP_002331933.1 4727610 R 574521 CDS YP_002331934.1 215489503 7061950 complement(4728337..4730145) 1 NC_011601.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 4730145 frdA 7061950 frdA Escherichia coli O127:H6 str. E2348/69 fumarate reductase flavoprotein subunit YP_002331934.1 4728337 R 574521 CDS YP_002331935.1 215489504 7061949 4730470..4731447 1 NC_011601.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4731447 poxA 7061949 poxA Escherichia coli O127:H6 str. E2348/69 lysyl-tRNA synthetase YP_002331935.1 4730470 D 574521 CDS YP_002331936.1 215489505 7061260 4731666..4733168 1 NC_011601.1 transporter 4733168 yjeM 7061260 yjeM Escherichia coli O127:H6 str. E2348/69 transporter YP_002331936.1 4731666 D 574521 CDS YP_002331937.1 215489506 7064112 complement(4733319..4736642) 1 NC_011601.1 hypothetical protein 4736642 yjeP 7064112 yjeP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331937.1 4733319 R 574521 CDS YP_002331938.1 215489507 7064113 complement(4736664..4737632) 1 NC_011601.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 4737632 psd 7064113 psd Escherichia coli O127:H6 str. E2348/69 phosphatidylserine decarboxylase YP_002331938.1 4736664 R 574521 CDS YP_002331939.1 215489508 7061315 complement(4737729..4738781) 1 NC_011601.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 4738781 rsgA 7061315 rsgA Escherichia coli O127:H6 str. E2348/69 ribosome-associated GTPase YP_002331939.1 4737729 R 574521 CDS YP_002331940.1 215489509 7064554 4738876..4739421 1 NC_011601.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4739421 orn 7064554 orn Escherichia coli O127:H6 str. E2348/69 oligoribonuclease YP_002331940.1 4738876 D 574521 CDS YP_002331941.1 215489510 7061728 complement(4740321..4741460) 1 NC_011601.1 Fe-S electron transport protein 4741460 yjeS 7061728 yjeS Escherichia coli O127:H6 str. E2348/69 Fe-S electron transport protein YP_002331941.1 4740321 R 574521 CDS YP_002331942.1 215489511 7064114 4741459..4743006 1 NC_011601.1 hypothetical protein 4743006 yjeF 7064114 yjeF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331942.1 4741459 D 574521 CDS YP_002331943.1 215489512 7064107 4742978..4743439 1 NC_011601.1 possibly involved in cell wall synthesis; ATPase 4743439 yjeE 7064107 yjeE Escherichia coli O127:H6 str. E2348/69 ATPase YP_002331943.1 4742978 D 574521 CDS YP_002331944.1 215489513 7064106 4743458..4744786 1 NC_011601.1 N-acetylmuramoyl-L-alanine amidase 4744786 amiB 7064106 amiB Escherichia coli O127:H6 str. E2348/69 N-acetylmuramoyl-L-alanine amidase YP_002331944.1 4743458 D 574521 CDS YP_002331945.1 215489514 7062453 4744796..4746643 1 NC_011601.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4746643 mutL 7062453 mutL Escherichia coli O127:H6 str. E2348/69 DNA mismatch repair protein YP_002331945.1 4744796 D 574521 CDS YP_002331946.1 215489515 7060898 4746636..4747586 1 NC_011601.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4747586 miaA 7060898 miaA Escherichia coli O127:H6 str. E2348/69 tRNA delta(2)-isopentenylpyrophosphate transferase YP_002331946.1 4746636 D 574521 CDS YP_002331947.1 215489516 7063783 4747672..4747980 1 NC_011601.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4747980 hfq 7063783 hfq Escherichia coli O127:H6 str. E2348/69 RNA-binding protein Hfq YP_002331947.1 4747672 D 574521 CDS YP_002331948.1 215489517 7064309 4748056..4749336 1 NC_011601.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX 4749336 hflX 7064309 hflX Escherichia coli O127:H6 str. E2348/69 GTPase HflX YP_002331948.1 4748056 D 574521 CDS YP_002331949.1 215489518 7064308 4749422..4750681 1 NC_011601.1 with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4750681 hflK 7064308 hflK Escherichia coli O127:H6 str. E2348/69 FtsH protease regulator HflK YP_002331949.1 4749422 D 574521 CDS YP_002331950.1 215489519 7064307 4750684..4751688 1 NC_011601.1 with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4751688 hflC 7064307 hflC Escherichia coli O127:H6 str. E2348/69 FtsH protease regulator HflC YP_002331950.1 4750684 D 574521 CDS YP_002331951.1 215489520 7064305 4751770..4751967 1 NC_011601.1 hypothetical protein 4751967 yjeT 7064305 yjeT Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331951.1 4751770 D 574521 CDS YP_002331952.1 215489521 7064115 4752071..4753369 1 NC_011601.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4753369 purA 7064115 purA Escherichia coli O127:H6 str. E2348/69 adenylosuccinate synthetase YP_002331952.1 4752071 D 574521 CDS YP_002331953.1 215489522 7063911 4753574..4753999 1 NC_011601.1 negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4753999 nsrR 7063911 nsrR Escherichia coli O127:H6 str. E2348/69 transcriptional repressor NsrR YP_002331953.1 4753574 D 574521 CDS YP_002331954.1 215489523 7065425 4754038..4756479 1 NC_011601.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4756479 rnr 7065425 rnr Escherichia coli O127:H6 str. E2348/69 exoribonuclease R YP_002331954.1 4754038 D 574521 CDS YP_002331955.1 215489524 7061820 4756571..4757302 1 NC_011601.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4757302 rlmB 7061820 rlmB Escherichia coli O127:H6 str. E2348/69 23S rRNA (guanosine-2'-O-)-methyltransferase YP_002331955.1 4756571 D 574521 CDS YP_002331956.1 215489525 7060833 4757429..4757830 1 NC_011601.1 hypothetical protein 4757830 yjfI 7060833 yjfI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331956.1 4757429 D 574521 CDS YP_002331957.1 215489526 7064118 4757849..4758547 1 NC_011601.1 transcriptional regulator effectorprotein 4758547 yjfJ 7064118 yjfJ Escherichia coli O127:H6 str. E2348/69 transcriptional regulator effectorprotein YP_002331957.1 4757849 D 574521 CDS YP_002331958.1 215489527 7064119 4758598..4759257 1 NC_011601.1 hypothetical protein 4759257 yjfK 7064119 yjfK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331958.1 4758598 D 574521 CDS YP_002331959.1 215489528 7064120 4759275..4759673 1 NC_011601.1 hypothetical protein 4759673 yjfL 7064120 yjfL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331959.1 4759275 D 574521 CDS YP_002331960.1 215489529 7064121 4759683..4760321 1 NC_011601.1 hypothetical protein 4760321 yjfM 7064121 yjfM Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331960.1 4759683 D 574521 CDS YP_002331961.1 215489530 7064122 4760324..4761487 1 NC_011601.1 synthetase/amidase 4761487 yjfC 7064122 yjfC Escherichia coli O127:H6 str. E2348/69 synthetase/amidase YP_002331961.1 4760324 D 574521 CDS YP_002331962.1 215489531 7064116 4761571..4763196 1 NC_011601.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4763196 aidB 7064116 aidB Escherichia coli O127:H6 str. E2348/69 isovaleryl CoA dehydrogenase YP_002331962.1 4761571 D 574521 CDS YP_002331963.1 215489532 7062427 complement(4763313..4763588) 1 NC_011601.1 hypothetical protein 4763588 yjfN 7062427 yjfN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331963.1 4763313 R 574521 CDS YP_002331964.1 215489533 7064123 complement(4763737..4764066) 1 NC_011601.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; biofilm stress and motility protein A 4764066 yjfO 7064123 yjfO Escherichia coli O127:H6 str. E2348/69 biofilm stress and motility protein A YP_002331964.1 4763737 R 574521 CDS YP_002331965.1 215489534 7064124 4764248..4764997 1 NC_011601.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4764997 yjfP 7064124 yjfP Escherichia coli O127:H6 str. E2348/69 esterase YP_002331965.1 4764248 D 574521 CDS YP_002331966.1 215489535 7064125 complement(4764994..4765749) 1 NC_011601.1 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 4765749 ulaR 7064125 ulaR Escherichia coli O127:H6 str. E2348/69 transcriptional repressor UlaR YP_002331966.1 4764994 R 574521 CDS YP_002331967.1 215489536 7062323 complement(4765857..4766921) 1 NC_011601.1 L-ascorbate 6-phosphate lactonase 4766921 ulaG 7062323 ulaG Escherichia coli O127:H6 str. E2348/69 L-ascorbate 6-phosphate lactonase YP_002331967.1 4765857 R 574521 CDS YP_002331968.1 215489537 7062322 4767276..4768673 1 NC_011601.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4768673 ulaA 7062322 ulaA Escherichia coli O127:H6 str. E2348/69 PTS system ascorbate-specific transporter subunit IIC YP_002331968.1 4767276 D 574521 CDS YP_002331969.1 215489538 7062316 4768689..4768994 1 NC_011601.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4768994 ulaB 7062316 ulaB Escherichia coli O127:H6 str. E2348/69 PTS system L-ascorbate-specific transporter subunit IIB YP_002331969.1 4768689 D 574521 CDS YP_002331970.1 215489539 7062317 4769004..4769468 1 NC_011601.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4769468 ulaC 7062317 ulaC Escherichia coli O127:H6 str. E2348/69 PTS system L-ascorbate-specific transporter subunit IIA YP_002331970.1 4769004 D 574521 CDS YP_002331971.1 215489540 7062318 4769482..4770132 1 NC_011601.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4770132 ulaD 7062318 ulaD Escherichia coli O127:H6 str. E2348/69 3-keto-L-gulonate-6-phosphate decarboxylase YP_002331971.1 4769482 D 574521 CDS YP_002331972.1 215489541 7062319 4770142..4770996 1 NC_011601.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4770996 ulaE 7062319 ulaE Escherichia coli O127:H6 str. E2348/69 L-xylulose 5-phosphate 3-epimerase YP_002331972.1 4770142 D 574521 CDS YP_002331973.1 215489542 7062320 4770996..4771676 1 NC_011601.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4771676 sgaE 7062320 sgaE Escherichia coli O127:H6 str. E2348/69 L-ribulose-5-phosphate 4-epimerase YP_002331973.1 4770996 D 574521 CDS YP_002331974.1 215489543 7062321 complement(4771805..4772080) 1 NC_011601.1 hypothetical protein 4772080 yjfY 7062321 yjfY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331974.1 4771805 R 574521 CDS YP_002331975.1 215489544 7064126 4772407..4772802 1 NC_011601.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4772802 rpsF 7064126 rpsF Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S6 YP_002331975.1 4772407 D 574521 CDS YP_002331976.1 215489545 7061878 4772809..4773123 1 NC_011601.1 binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4773123 priB 7061878 priB Escherichia coli O127:H6 str. E2348/69 primosomal replication protein N YP_002331976.1 4772809 D 574521 CDS YP_002331977.1 215489546 7061289 4773128..4773355 1 NC_011601.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4773355 rpsR 7061289 rpsR Escherichia coli O127:H6 str. E2348/69 30S ribosomal protein S18 YP_002331977.1 4773128 D 574521 CDS YP_002331978.1 215489547 7061890 4773397..4773846 1 NC_011601.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4773846 rplI 7061890 rplI Escherichia coli O127:H6 str. E2348/69 50S ribosomal protein L9 YP_002331978.1 4773397 D 574521 CDS YP_002331979.1 215489548 7061836 4774248..4774727 1 NC_011601.1 hypothetical protein 4774727 7061836 E2348C_4527 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331979.1 4774248 D 574521 CDS YP_002331980.1 215489549 7065149 complement(4776151..4777428) 1 NC_011601.1 hexuronate transporter 4777428 7065149 E2348C_4529 Escherichia coli O127:H6 str. E2348/69 hexuronate transporter YP_002331980.1 4776151 R 574521 CDS YP_002331981.1 215489550 7065150 complement(4777521..4779593) 1 NC_011601.1 oxidoreductase 4779593 7065150 E2348C_4530 Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002331981.1 4777521 R 574521 CDS YP_002331982.1 215489551 7065151 complement(4779590..4781131) 1 NC_011601.1 acetyl-CoA: acetoacetyl-CoA transferase 4781131 7065151 E2348C_4531 Escherichia coli O127:H6 str. E2348/69 acetyl-CoA: acetoacetyl-CoA transferase YP_002331982.1 4779590 R 574521 CDS YP_002331983.1 215489552 7065152 complement(4781141..4781917) 1 NC_011601.1 3-hydroxybutyryl-CoA dehydratase 4781917 7065152 E2348C_4532 Escherichia coli O127:H6 str. E2348/69 3-hydroxybutyryl-CoA dehydratase YP_002331983.1 4781141 R 574521 CDS YP_002331984.1 215489553 7065153 complement(4781927..4782769) 1 NC_011601.1 hypothetical protein 4782769 7065153 E2348C_4533 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331984.1 4781927 R 574521 CDS YP_002331985.1 215489554 7065154 complement(4782779..4783570) 1 NC_011601.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 4783570 7065154 E2348C_4534 Escherichia coli O127:H6 str. E2348/69 3-ketoacyl-ACP reductase YP_002331985.1 4782779 R 574521 CDS YP_002331986.1 215489555 7065155 4783784..4784431 1 NC_011601.1 transcriptional regulator 4784431 ytfA 7065155 ytfA Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002331986.1 4783784 D 574521 CDS YP_002331987.1 215489556 7063240 complement(4784415..4785053) 1 NC_011601.1 cell envelope opacity-associated protein 4785053 ytfB 7063240 ytfB Escherichia coli O127:H6 str. E2348/69 cell envelope opacity-associated protein YP_002331987.1 4784415 R 574521 CDS YP_002331988.1 215489557 7063241 4785271..4785891 1 NC_011601.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4785891 fklB 7063241 fklB Escherichia coli O127:H6 str. E2348/69 peptidyl-prolyl cis-trans isomerase YP_002331988.1 4785271 D 574521 CDS YP_002331989.1 215489558 7065156 4787758..4789170 1 NC_011601.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4789170 cycA 7065156 cycA Escherichia coli O127:H6 str. E2348/69 D-alanine/D-serine/glycine permease YP_002331989.1 4787758 D 574521 CDS YP_002331990.1 215489559 7065183 complement(4789215..4789877) 1 NC_011601.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 4789877 ytfE 7065183 ytfE Escherichia coli O127:H6 str. E2348/69 iron-sulfur cluster repair di-iron protein YP_002331990.1 4789215 R 574521 CDS YP_002331991.1 215489560 7063242 complement(4789985..4790959) 1 NC_011601.1 hypothetical protein 4790959 ytfF 7063242 ytfF Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331991.1 4789985 R 574521 CDS YP_002331992.1 215489561 7063243 complement(4791059..4791919) 1 NC_011601.1 NAD(P)H: quinone oxidoreductase 4791919 ytfG 7063243 ytfG Escherichia coli O127:H6 str. E2348/69 NAD(P)H: quinone oxidoreductase YP_002331992.1 4791059 R 574521 CDS YP_002331993.1 215489562 7063244 4792008..4792388 1 NC_011601.1 transcriptional regulator 4792388 ytfH 7063244 ytfH Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002331993.1 4792008 D 574521 CDS YP_002331994.1 215489563 7063245 complement(4792517..4794460) 1 NC_011601.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 4794460 cpdB 7063245 cpdB Escherichia coli O127:H6 str. E2348/69 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein YP_002331994.1 4792517 R 574521 CDS YP_002331995.1 215489564 7062835 4794650..4795390 1 NC_011601.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4795390 cysQ 7062835 cysQ Escherichia coli O127:H6 str. E2348/69 adenosine-3'(2'),5'-bisphosphate nucleotidase YP_002331995.1 4794650 D 574521 CDS YP_002331996.1 215489565 7065205 complement(4795380..4795937) 1 NC_011601.1 transcriptional regulator 4795937 ytfJ 7065205 ytfJ Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002331996.1 4795380 R 574521 CDS YP_002331997.1 215489566 7063246 4796262..4796468 1 NC_011601.1 hypothetical protein 4796468 ytfK 7063246 ytfK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331997.1 4796262 D 574521 CDS YP_002331998.1 215489567 7063247 complement(4796546..4797889) 1 NC_011601.1 hypothetical protein 4797889 ytfL 7063247 ytfL Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002331998.1 4796546 R 574521 CDS YP_002331999.1 215489568 7063248 complement(4798212..4798850) 1 NC_011601.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 4798850 msrA 7063248 msrA Escherichia coli O127:H6 str. E2348/69 methionine sulfoxide reductase A YP_002331999.1 4798212 R 574521 CDS YP_002332000.1 215489569 7060874 4799056..4800789 1 NC_011601.1 outer membrane protein 4800789 ytfM 7060874 ytfM Escherichia coli O127:H6 str. E2348/69 outer membrane protein YP_002332000.1 4799056 D 574521 CDS YP_002332001.1 215489570 7063249 4800786..4804565 1 NC_011601.1 hypothetical protein 4804565 ytfN 7063249 ytfN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332001.1 4800786 D 574521 CDS YP_002332002.1 215489571 7063250 4804568..4804909 1 NC_011601.1 hypothetical protein 4804909 ytfP 7063250 ytfP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332002.1 4804568 D 574521 CDS YP_002332003.1 215489572 7063251 complement(4805289..4805819) 1 NC_011601.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 4805819 ppa 7063251 ppa Escherichia coli O127:H6 str. E2348/69 inorganic pyrophosphatase YP_002332003.1 4805289 R 574521 CDS YP_002332004.1 215489573 7061262 4806129..4807085 1 NC_011601.1 sugar transporter subunit: periplasmic-binding component of ABC superfamily 4807085 ytfQ 7061262 ytfQ Escherichia coli O127:H6 str. E2348/69 sugar transporter subunit: periplasmic-binding component of ABC superfamily YP_002332004.1 4806129 D 574521 CDS YP_002332005.1 215489574 7063252 4807225..4808727 1 NC_011601.1 sugar transporter subunit: ATP-binding component of ABC superfamily 4808727 ytfR 7063252 ytfR Escherichia coli O127:H6 str. E2348/69 sugar transporter subunit: ATP-binding component of ABC superfamily YP_002332005.1 4807225 D 574521 CDS YP_002332006.1 215489575 7063253 4808741..4809763 1 NC_011601.1 sugar transporter subunit: membrane component of ABC superfamily 4809763 ytfT 7063253 ytfT Escherichia coli O127:H6 str. E2348/69 sugar transporter subunit: membrane component of ABC superfamily YP_002332006.1 4808741 D 574521 CDS YP_002332007.1 215489576 7063254 4809750..4810745 1 NC_011601.1 membrane component of a sugar ABC transporter system; ABC transporter permease 4810745 yjfF 7063254 yjfF Escherichia coli O127:H6 str. E2348/69 ABC transporter permease YP_002332007.1 4809750 D 574521 CDS YP_002332008.1 215489577 7064117 complement(4810778..4811776) 1 NC_011601.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 4811776 fbp 7064117 fbp Escherichia coli O127:H6 str. E2348/69 fructose-1,6-bisphosphatase YP_002332008.1 4810778 R 574521 CDS YP_002332009.1 215489578 7062083 4811952..4813325 1 NC_011601.1 UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase 4813325 mpl 7062083 mpl Escherichia coli O127:H6 str. E2348/69 UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase YP_002332009.1 4811952 D 574521 CDS YP_002332010.1 215489579 7063825 complement(4813477..4814028) 1 NC_011601.1 hypothetical protein 4814028 yjgA 7063825 yjgA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332010.1 4813477 R 574521 CDS YP_002332011.1 215489580 7064127 4814122..4815474 1 NC_011601.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4815474 pmbA 7064127 pmbA Escherichia coli O127:H6 str. E2348/69 peptidase PmbA YP_002332011.1 4814122 D 574521 CDS YP_002332012.1 215489581 7060759 4815657..4816043 1 NC_011601.1 cytochrome b562 4816043 cybC 7060759 cybC Escherichia coli O127:H6 str. E2348/69 cytochrome b562 YP_002332012.1 4815657 D 574521 CDS YP_002332013.1 215489582 7065182 complement(4816088..4816552) 1 NC_011601.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 4816552 nrdG 7065182 nrdG Escherichia coli O127:H6 str. E2348/69 anaerobic ribonucleotide reductase-activating protein YP_002332013.1 4816088 R 574521 CDS YP_002332014.1 215489583 7065414 complement(4816710..4818848) 1 NC_011601.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 4818848 nrdD 7065414 nrdD Escherichia coli O127:H6 str. E2348/69 anaerobic ribonucleoside triphosphate reductase YP_002332014.1 4816710 R 574521 CDS YP_002332015.1 215489584 7065411 complement(4819242..4820897) 1 NC_011601.1 trehalose-6-phosphate hydrolase 4820897 treC 7065411 treC Escherichia coli O127:H6 str. E2348/69 trehalose-6-phosphate hydrolase YP_002332015.1 4819242 R 574521 CDS YP_002332016.1 215489585 7062235 complement(4820947..4822368) 1 NC_011601.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunit IIBC 4822368 treB 7062235 treB Escherichia coli O127:H6 str. E2348/69 PTS system trehalose(maltose)-specific transporter subunit IIBC YP_002332016.1 4820947 R 574521 CDS YP_002332017.1 215489586 7062234 complement(4822487..4823434) 1 NC_011601.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 4823434 treR 7062234 treR Escherichia coli O127:H6 str. E2348/69 trehalose repressor YP_002332017.1 4822487 R 574521 CDS YP_002332018.1 215489587 7062237 4823813..4826509 1 NC_011601.1 P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4826509 mgtA 7062237 mgtA Escherichia coli O127:H6 str. E2348/69 magnesium-transporting ATPase MgtA YP_002332018.1 4823813 D 574521 CDS YP_002332019.1 215489588 7063782 complement(4826715..4827101) 1 NC_011601.1 ketoacid-binding protein 4827101 yjgF 7063782 yjgF Escherichia coli O127:H6 str. E2348/69 ketoacid-binding protein YP_002332019.1 4826715 R 574521 CDS YP_002332020.1 215489589 7064129 complement(4827174..4827635) 1 NC_011601.1 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase 4827635 pyrI 7064129 pyrI Escherichia coli O127:H6 str. E2348/69 aspartate carbamoyltransferase YP_002332020.1 4827174 R 574521 CDS YP_002332021.1 215489590 7063936 complement(4827648..4828583) 1 NC_011601.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 4828583 pyrB 7063936 pyrB Escherichia coli O127:H6 str. E2348/69 aspartate carbamoyltransferase YP_002332021.1 4827648 R 574521 CDS YP_002332022.1 215489591 7063929 complement(4828587..4828721) 1 NC_011601.1 pyrBI operon leader peptide 4828721 pyrL 7063929 pyrL Escherichia coli O127:H6 str. E2348/69 pyrBI operon leader peptide YP_002332022.1 4828587 R 574521 CDS YP_002332023.1 215489592 7063937 complement(4829002..4829397) 1 NC_011601.1 mRNA endoribonuclease 4829397 yjgH 7063937 yjgH Escherichia coli O127:H6 str. E2348/69 mRNA endoribonuclease YP_002332023.1 4829002 R 574521 CDS YP_002332024.1 215489593 7064130 complement(4829528..4830241) 1 NC_011601.1 oxidoreductase 4830241 yjgI 7064130 yjgI Escherichia coli O127:H6 str. E2348/69 oxidoreductase YP_002332024.1 4829528 R 574521 CDS YP_002332025.1 215489594 7064131 4830312..4830905 1 NC_011601.1 transcriptional regulator 4830905 yjgJ 7064131 yjgJ Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002332025.1 4830312 D 574521 CDS YP_002332026.1 215489595 7064132 4831050..4831502 1 NC_011601.1 hypothetical protein 4831502 yjgK 7064132 yjgK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332026.1 4831050 D 574521 CDS YP_002332027.1 215489596 7064134 complement(4833304..4834317) 1 NC_011601.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I 4834317 argI 7064134 argI Escherichia coli O127:H6 str. E2348/69 ornithine carbamoyltransferase subunit I YP_002332027.1 4833304 R 574521 CDS YP_002332028.1 215489597 7061372 4834479..4834895 1 NC_011601.1 hypothetical protein 4834895 rraB 7061372 rraB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332028.1 4834479 D 574521 CDS YP_002332029.1 215489598 7061895 complement(4834941..4835444) 1 NC_011601.1 acetyltransferase 4835444 yjgM 7061895 yjgM Escherichia coli O127:H6 str. E2348/69 acetyltransferase YP_002332029.1 4834941 R 574521 CDS YP_002332030.1 215489599 7064135 4835637..4836824 1 NC_011601.1 hypothetical protein 4836824 yjgN 7064135 yjgN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332030.1 4835637 D 574521 CDS YP_002332031.1 215489600 7064136 complement(4836871..4839726) 1 NC_011601.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 4839726 valS 7064136 valS Escherichia coli O127:H6 str. E2348/69 valyl-tRNA synthetase YP_002332031.1 4836871 R 574521 CDS YP_002332032.1 215489601 7062352 complement(4839726..4840169) 1 NC_011601.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 4840169 holC 7062352 holC Escherichia coli O127:H6 str. E2348/69 DNA polymerase III subunit chi YP_002332032.1 4839726 R 574521 CDS YP_002332033.1 215489602 7062173 complement(4840331..4841842) 1 NC_011601.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 4841842 pepA 7062173 pepA Escherichia coli O127:H6 str. E2348/69 leucyl aminopeptidase YP_002332033.1 4840331 R 574521 CDS YP_002332034.1 215489603 7062945 4842109..4843209 1 NC_011601.1 hypothetical protein 4843209 yjgP 7062945 yjgP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332034.1 4842109 D 574521 CDS YP_002332035.1 215489604 7064137 4843209..4844291 1 NC_011601.1 hypothetical protein 4844291 yjgQ 7064137 yjgQ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332035.1 4843209 D 574521 CDS YP_002332036.1 215489605 7064138 complement(4844399..4845913) 1 NC_011601.1 ATPase 4845913 yjgR 7064138 yjgR Escherichia coli O127:H6 str. E2348/69 ATPase YP_002332036.1 4844399 R 574521 CDS YP_002332037.1 215489606 7064139 complement(4846043..4847062) 1 NC_011601.1 alcohol dehydrogenase, Zn-dependentand NAD(P)-binding 4847062 yjgB 7064139 yjgB Escherichia coli O127:H6 str. E2348/69 alcohol dehydrogenase, Zn-dependentand NAD(P)-binding YP_002332037.1 4846043 R 574521 CDS YP_002332038.1 215489607 7061165 4847860..4848408 1 NC_011601.1 hypothetical protein 4848408 7061165 E2348C_4589 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332038.1 4847860 D 574521 CDS YP_002332039.1 215489608 7065157 complement(4849160..4849921) 1 NC_011601.1 hypothetical protein 4849921 7065157 E2348C_4590 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332039.1 4849160 R 574521 CDS YP_002332040.1 215489609 7065158 4850315..4850884 1 NC_011601.1 serine site-specific recombinase 4850884 7065158 E2348C_4591 Escherichia coli O127:H6 str. E2348/69 serine site-specific recombinase YP_002332040.1 4850315 D 574521 CDS YP_002332041.1 215489610 7065159 4850887..4851123 1 NC_011601.1 hypothetical protein 4851123 7065159 E2348C_4592 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332041.1 4850887 D 574521 CDS YP_002332042.1 215489611 7065160 4852747..4853994 1 NC_011601.1 ATP-dependent DNA helicase (N-terminus) 4853994 7065160 E2348C_4593 Escherichia coli O127:H6 str. E2348/69 ATP-dependent DNA helicase (N-terminus) YP_002332042.1 4852747 D 574521 CDS YP_002332043.1 215489612 7065161 4854032..4854469 1 NC_011601.1 hypothetical protein 4854469 7065161 E2348C_4594 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332043.1 4854032 D 574521 CDS YP_002332044.1 215489613 7065162 4854466..4854675 1 NC_011601.1 hypothetical protein 4854675 7065162 E2348C_4595 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332044.1 4854466 D 574521 CDS YP_002332045.1 215489614 7064923 4854845..4855408 1 NC_011601.1 hypothetical protein 4855408 7064923 E2348C_4596 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332045.1 4854845 D 574521 CDS YP_002332046.1 215489615 7064924 4855405..4855641 1 NC_011601.1 hypothetical protein 4855641 7064924 E2348C_4597 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332046.1 4855405 D 574521 CDS YP_002332047.1 215489616 7064925 4855654..4855893 1 NC_011601.1 hypothetical protein 4855893 7064925 E2348C_4598 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332047.1 4855654 D 574521 CDS YP_002332048.1 215489617 7064926 4855897..4856577 1 NC_011601.1 hypothetical protein 4856577 7064926 E2348C_4599 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332048.1 4855897 D 574521 CDS YP_002332049.1 215489618 7064927 4856717..4857130 1 NC_011601.1 hypothetical protein 4857130 7064927 E2348C_4600 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332049.1 4856717 D 574521 CDS YP_002332050.1 215489619 7064928 4857350..4858345 1 NC_011601.1 capsid protein 4858345 7064928 E2348C_4601 Escherichia coli O127:H6 str. E2348/69 capsid protein YP_002332050.1 4857350 D 574521 CDS YP_002332051.1 215489620 7064929 4858362..4858871 1 NC_011601.1 endonuclease, HNH family 4858871 7064929 E2348C_4602 Escherichia coli O127:H6 str. E2348/69 endonuclease, HNH family YP_002332051.1 4858362 D 574521 CDS YP_002332052.1 215489621 7064930 4858890..4859315 1 NC_011601.1 hypothetical protein 4859315 7064930 E2348C_4603 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332052.1 4858890 D 574521 CDS YP_002332053.1 215489622 7064931 4859347..4859598 1 NC_011601.1 hypothetical protein 4859598 7064931 E2348C_4604 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332053.1 4859347 D 574521 CDS YP_002332054.1 215489623 7064932 4859571..4859996 1 NC_011601.1 hypothetical protein 4859996 7064932 E2348C_4605 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332054.1 4859571 D 574521 CDS YP_002332055.1 215489624 7064933 complement(4860038..4860940) 1 NC_011601.1 hypothetical protein 4860940 7064933 E2348C_4606 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332055.1 4860038 R 574521 CDS YP_002332056.1 215489625 7064934 complement(4861028..4862239) 1 NC_011601.1 integrase 4862239 7064934 E2348C_4607 Escherichia coli O127:H6 str. E2348/69 integrase YP_002332056.1 4861028 R 574521 CDS YP_002332057.1 215489626 7064935 complement(4862628..4865744) 1 NC_011601.1 type I restriction-modification enzyme R subunit 4865744 7064935 E2348C_4608 Escherichia coli O127:H6 str. E2348/69 type I restriction-modification enzyme R subunit YP_002332057.1 4862628 R 574521 CDS YP_002332058.1 215489627 7064936 complement(4865866..4867092) 1 NC_011601.1 type I restriction-modification enzyme S subunit 4867092 7064936 E2348C_4609 Escherichia coli O127:H6 str. E2348/69 type I restriction-modification enzyme S subunit YP_002332058.1 4865866 R 574521 CDS YP_002332059.1 215489628 7064937 complement(4867089..4868645) 1 NC_011601.1 type I restriction-modification enzyme M subunit 4868645 7064937 E2348C_4610 Escherichia coli O127:H6 str. E2348/69 type I restriction-modification enzyme M subunit YP_002332059.1 4867089 R 574521 CDS YP_002332060.1 215489629 7064938 4868952..4869785 1 NC_011601.1 hypothetical protein 4869785 7064938 E2348C_4611 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332060.1 4868952 D 574521 CDS YP_002332061.1 215489630 7064939 4870147..4872201 1 NC_011601.1 McrB family protein, GTPase subunit of restriction endonuclease 4872201 7064939 E2348C_4612 Escherichia coli O127:H6 str. E2348/69 McrB family protein, GTPase subunit of restriction endonuclease YP_002332061.1 4870147 D 574521 CDS YP_002332062.1 215489631 7064940 4872198..4873508 1 NC_011601.1 McrC family protein, McrBC 5-methylcytosine restriction system component 4873508 7064940 E2348C_4613 Escherichia coli O127:H6 str. E2348/69 McrC family protein, McrBC 5-methylcytosine restriction system component YP_002332062.1 4872198 D 574521 CDS YP_002332063.1 215489632 7064941 complement(4873571..4874476) 1 NC_011601.1 restriction endonuclease 4874476 7064941 E2348C_4614 Escherichia coli O127:H6 str. E2348/69 restriction endonuclease YP_002332063.1 4873571 R 574521 CDS YP_002332064.1 215489633 7064943 complement(4875238..4876218) 1 NC_011601.1 hypothetical protein 4876218 yjhS 7064943 yjhS Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332064.1 4875238 R 574521 CDS YP_002332065.1 215489634 7064140 complement(4876283..4877389) 1 NC_011601.1 N-acetylneuraminic acid mutarotase 4877389 yjhT 7064140 yjhT Escherichia coli O127:H6 str. E2348/69 N-acetylneuraminic acid mutarotase YP_002332065.1 4876283 R 574521 CDS YP_002332066.1 215489635 7064141 complement(4877409..4878125) 1 NC_011601.1 N-acetylnuraminic acid outer membrane channel protein 4878125 nanC 7064141 nanC Escherichia coli O127:H6 str. E2348/69 N-acetylnuraminic acid outer membrane channel protein YP_002332066.1 4877409 R 574521 CDS YP_002332067.1 215489636 7060919 4879589..4880191 1 NC_011601.1 inversion of on/off regulator of fimA; tyrosine recombinase 4880191 fimB 7060919 fimB Escherichia coli O127:H6 str. E2348/69 tyrosine recombinase YP_002332067.1 4879589 D 574521 CDS YP_002332068.1 215489637 7062120 4880669..4881265 1 NC_011601.1 inversion of on/off regulator of fimA; tyrosine recombinase 4881265 fimE 7062120 fimE Escherichia coli O127:H6 str. E2348/69 tyrosine recombinase YP_002332068.1 4880669 D 574521 CDS YP_002332069.1 215489638 7062123 4881746..4882294 1 NC_011601.1 major type 1 subunit fimbrin (pilin) 4882294 fimA 7062123 fimA Escherichia coli O127:H6 str. E2348/69 major type 1 subunit fimbrin (pilin) YP_002332069.1 4881746 D 574521 CDS YP_002332070.1 215489639 7062119 4882359..4882898 1 NC_011601.1 type 1 pilus biosynthesis fimbrial protein 4882898 fimI 7062119 fimI Escherichia coli O127:H6 str. E2348/69 type 1 pilus biosynthesis fimbrial protein YP_002332070.1 4882359 D 574521 CDS YP_002332071.1 215489640 7062127 4882935..4883660 1 NC_011601.1 chaperone, periplasmic 4883660 fimC 7062127 fimC Escherichia coli O127:H6 str. E2348/69 chaperone, periplasmic YP_002332071.1 4882935 D 574521 CDS YP_002332072.1 215489641 7062121 4883726..4886362 1 NC_011601.1 outer membrane usher protein, type 1 fimbrial synthesis 4886362 fimD 7062121 fimD Escherichia coli O127:H6 str. E2348/69 outer membrane usher protein, type 1 fimbrial synthesis YP_002332072.1 4883726 D 574521 CDS YP_002332073.1 215489642 7062122 4886372..4886902 1 NC_011601.1 minor component of type 1 fimbriae 4886902 fimF 7062122 fimF Escherichia coli O127:H6 str. E2348/69 minor component of type 1 fimbriae YP_002332073.1 4886372 D 574521 CDS YP_002332074.1 215489643 7062124 4886915..4887418 1 NC_011601.1 minor component of type 1 fimbriae 4887418 fimG 7062124 fimG Escherichia coli O127:H6 str. E2348/69 minor component of type 1 fimbriae YP_002332074.1 4886915 D 574521 CDS YP_002332075.1 215489644 7062125 4887438..4888340 1 NC_011601.1 minor component of type 1 fimbriae 4888340 fimH 7062125 fimH Escherichia coli O127:H6 str. E2348/69 minor component of type 1 fimbriae YP_002332075.1 4887438 D 574521 CDS YP_002332076.1 215489645 7062126 4889072..4890256 1 NC_011601.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 4890256 uxuA 7062126 uxuA Escherichia coli O127:H6 str. E2348/69 mannonate dehydratase YP_002332076.1 4889072 D 574521 CDS YP_002332077.1 215489646 7062348 4890337..4891797 1 NC_011601.1 D-mannonate oxidoreductase, NAD-binding 4891797 uxuB 7062348 uxuB Escherichia coli O127:H6 str. E2348/69 D-mannonate oxidoreductase, NAD-binding YP_002332077.1 4890337 D 574521 CDS YP_002332078.1 215489647 7062349 4892012..4892785 1 NC_011601.1 regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 4892785 uxuR 7062349 uxuR Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional repressor UxuR YP_002332078.1 4892012 D 574521 CDS YP_002332079.1 215489648 7062350 4893199..4893582 1 NC_011601.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 4893582 iraD 7062350 iraD Escherichia coli O127:H6 str. E2348/69 DNA replication/recombination/repair protein YP_002332079.1 4893199 D 574521 CDS YP_002332080.1 215489649 7061278 complement(4894008..4894919) 1 NC_011601.1 DNA-binding transcriptional regulator 4894919 yjiE 7061278 yjiE Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002332080.1 4894008 R 574521 CDS YP_002332081.1 215489650 7064143 complement(4894984..4896156) 1 NC_011601.1 isoaspartyl dipeptidase 4896156 iadA 7064143 iadA Escherichia coli O127:H6 str. E2348/69 isoaspartyl dipeptidase YP_002332081.1 4894984 R 574521 CDS YP_002332082.1 215489651 7063513 complement(4896169..4896630) 1 NC_011601.1 hypothetical protein 4896630 yjiG 7063513 yjiG Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332082.1 4896169 R 574521 CDS YP_002332083.1 215489652 7064144 complement(4896627..4897310) 1 NC_011601.1 hypothetical protein 4897310 yjiH 7064144 yjiH Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332083.1 4896627 R 574521 CDS YP_002332084.1 215489653 7064145 4897458..4898114 1 NC_011601.1 in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown; RNA 2'-phosphotransferase-like protein 4898114 kptA 7064145 kptA Escherichia coli O127:H6 str. E2348/69 RNA 2'-phosphotransferase-like protein YP_002332084.1 4897458 D 574521 CDS YP_002332085.1 215489654 7061505 complement(4898127..4899305) 1 NC_011601.1 hypothetical protein 4899305 yjiJ 7061505 yjiJ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332085.1 4898127 R 574521 CDS YP_002332086.1 215489655 7064146 complement(4899373..4900233) 1 NC_011601.1 hypothetical protein 4900233 yjiK 7064146 yjiK Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332086.1 4899373 R 574521 CDS YP_002332087.1 215489656 7064147 complement(4900298..4900555) 1 NC_011601.1 hypothetical protein 4900555 7064147 E2348C_4640 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332087.1 4900298 R 574521 CDS YP_002332088.1 215489657 7064945 complement(4900552..4901319) 1 NC_011601.1 ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase 4901319 yjiL 7064945 yjiL Escherichia coli O127:H6 str. E2348/69 ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase YP_002332088.1 4900552 R 574521 CDS YP_002332089.1 215489658 7064148 complement(4901329..4902480) 1 NC_011601.1 2-hydroxyglutaryl-CoA dehydratase 4902480 yjiM 7064148 yjiM Escherichia coli O127:H6 str. E2348/69 2-hydroxyglutaryl-CoA dehydratase YP_002332089.1 4901329 R 574521 CDS YP_002332090.1 215489659 7064149 complement(4902596..4903876) 1 NC_011601.1 hypothetical protein 4903876 yjiN 7064149 yjiN Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332090.1 4902596 R 574521 CDS YP_002332091.1 215489660 7064068 4904061..4904981 1 NC_011601.1 hypothetical protein 4904981 yjiP 7064068 yjiP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332091.1 4904061 D 574521 CDS YP_002332092.1 215489661 7061977 complement(4905670..4906008) 1 NC_011601.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE 4906008 yjiW 7061977 yjiW Escherichia coli O127:H6 str. E2348/69 endoribonuclease SymE YP_002332092.1 4905670 R 574521 CDS YP_002332093.1 215489662 7061978 complement(4906661..4908511) 1 NC_011601.1 helicase 4908511 7061978 E2348C_4647 Escherichia coli O127:H6 str. E2348/69 helicase YP_002332093.1 4906661 R 574521 CDS YP_002332094.1 215489663 7064946 complement(4908842..4909798) 1 NC_011601.1 GTP-binding protein YjiA 4909798 yjiA 7064946 yjiA Escherichia coli O127:H6 str. E2348/69 GTP-binding protein YjiA YP_002332094.1 4908842 R 574521 CDS YP_002332095.1 215489664 7064142 complement(4909809..4910012) 1 NC_011601.1 hypothetical protein 4910012 yjiX 7064142 yjiX Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332095.1 4909809 R 574521 CDS YP_002332096.1 215489665 7061979 complement(4910062..4912212) 1 NC_011601.1 hypothetical protein 4912212 yjiY 7061979 yjiY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332096.1 4910062 R 574521 CDS YP_002332097.1 215489666 7061980 4912589..4914253 1 NC_011601.1 methyl-accepting chemotaxis protein I, serine sensor receptor 4914253 tsr 7061980 tsr Escherichia coli O127:H6 str. E2348/69 methyl-accepting chemotaxis protein I, serine sensor receptor YP_002332097.1 4912589 D 574521 CDS YP_002332098.1 215489667 7062272 complement(4914296..4915567) 1 NC_011601.1 TRAP-type C4-dicarboxylate transport system, large permease component 4915567 7062272 E2348C_4652 Escherichia coli O127:H6 str. E2348/69 TRAP-type C4-dicarboxylate transport system, large permease component YP_002332098.1 4914296 R 574521 CDS YP_002332099.1 215489668 7064947 complement(4915564..4916037) 1 NC_011601.1 TRAP-type C4-dicarboxylate transport system, small permease component 4916037 7064947 E2348C_4653 Escherichia coli O127:H6 str. E2348/69 TRAP-type C4-dicarboxylate transport system, small permease component YP_002332099.1 4915564 R 574521 CDS YP_002332100.1 215489669 7064949 4917762..4919414 1 NC_011601.1 Na+/H+ and K+/H+ transporter 4919414 7064949 E2348C_4655 Escherichia coli O127:H6 str. E2348/69 Na+/H+ and K+/H+ transporter YP_002332100.1 4917762 D 574521 CDS YP_002332101.1 215489670 7064950 complement(4919585..4920490) 1 NC_011601.1 DNA-binding transcriptional regulator 4920490 yjjM 7064950 yjjM Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002332101.1 4919585 R 574521 CDS YP_002332102.1 215489671 7061986 4920629..4921651 1 NC_011601.1 oxidoreductase, Zn-dependent and NAD (P)-binding 4921651 yjjN 7061986 yjjN Escherichia coli O127:H6 str. E2348/69 oxidoreductase, Zn-dependent and NAD (P)-binding YP_002332102.1 4920629 D 574521 CDS YP_002332103.1 215489672 7061987 complement(4921791..4924082) 1 NC_011601.1 catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I 4924082 mdoB 7061987 mdoB Escherichia coli O127:H6 str. E2348/69 phosphoglycerol transferase I YP_002332103.1 4921791 R 574521 CDS YP_002332104.1 215489673 7065301 complement(4924336..4924833) 1 NC_011601.1 hypothetical protein 4924833 yjjA 7065301 yjjA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332104.1 4924336 R 574521 CDS YP_002332105.1 215489674 7061981 complement(4924879..4925616) 1 NC_011601.1 acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC 4925616 dnaC 7061981 dnaC Escherichia coli O127:H6 str. E2348/69 DNA replication protein DnaC YP_002332105.1 4924879 R 574521 CDS YP_002332106.1 215489675 7065046 complement(4925619..4926158) 1 NC_011601.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI 4926158 dnaT 7065046 dnaT Escherichia coli O127:H6 str. E2348/69 primosomal protein DnaI YP_002332106.1 4925619 R 574521 CDS YP_002332107.1 215489676 7065053 complement(4926265..4926738) 1 NC_011601.1 hypothetical protein 4926738 yjjB 7065053 yjjB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332107.1 4926265 R 574521 CDS YP_002332108.1 215489677 7061982 complement(4926729..4927499) 1 NC_011601.1 hypothetical protein 4927499 yjjP 7061982 yjjP Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332108.1 4926729 R 574521 CDS YP_002332109.1 215489678 7061988 4928118..4928843 1 NC_011601.1 DNA-binding transcriptional regulator 4928843 yjjQ 7061988 yjjQ Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional regulator YP_002332109.1 4928118 D 574521 CDS YP_002332110.1 215489679 7061989 4928801..4929478 1 NC_011601.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 4929478 bglJ 7061989 bglJ Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator BglJ YP_002332110.1 4928801 D 574521 CDS YP_002332111.1 215489680 7062517 complement(4929516..4930304) 1 NC_011601.1 ferric hydroximate transport ferric iron reductase 4930304 fhuF 7062517 fhuF Escherichia coli O127:H6 str. E2348/69 ferric hydroximate transport ferric iron reductase YP_002332111.1 4929516 R 574521 CDS YP_002332112.1 215489681 7062116 4930445..4930681 1 NC_011601.1 hypothetical protein 4930681 yjjZ 7062116 yjjZ Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332112.1 4930445 D 574521 CDS YP_002332113.1 215489682 7061529 complement(4931343..4932374) 1 NC_011601.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 4932374 rsmC 7061529 rsmC Escherichia coli O127:H6 str. E2348/69 16S ribosomal RNA m2G1207 methyltransferase YP_002332113.1 4931343 R 574521 CDS YP_002332114.1 215489683 7064556 4932477..4932890 1 NC_011601.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 4932890 holD 7064556 holD Escherichia coli O127:H6 str. E2348/69 DNA polymerase III subunit psi YP_002332114.1 4932477 D 574521 CDS YP_002332115.1 215489684 7062174 4932859..4933305 1 NC_011601.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 4933305 rimI 7062174 rimI Escherichia coli O127:H6 str. E2348/69 ribosomal-protein-alanine N-acetyltransferase YP_002332115.1 4932859 D 574521 CDS YP_002332116.1 215489685 7060827 4933320..4933997 1 NC_011601.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 4933997 yjjG 7060827 yjjG Escherichia coli O127:H6 str. E2348/69 nucleotidase YP_002332116.1 4933320 D 574521 CDS YP_002332117.1 215489686 7061983 4934088..4935677 1 NC_011601.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 4935677 prfC 7061983 prfC Escherichia coli O127:H6 str. E2348/69 peptide chain release factor 3 YP_002332117.1 4934088 D 574521 CDS YP_002332118.1 215489687 7061286 4936070..4936675 1 NC_011601.1 hypothetical protein 4936675 osmY 7061286 osmY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332118.1 4936070 D 574521 CDS YP_002332119.1 215489688 7062893 4936802..4936963 1 NC_011601.1 hypothetical protein 4936963 ytjA 7062893 ytjA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332119.1 4936802 D 574521 CDS YP_002332120.1 215489689 7063255 4937085..4938158 1 NC_011601.1 esterase 4938158 yjjU 7063255 yjjU Escherichia coli O127:H6 str. E2348/69 esterase YP_002332120.1 4937085 D 574521 CDS YP_002332121.1 215489690 7061990 4938155..4938934 1 NC_011601.1 deoxyribonuclease YjjV 4938934 yjjV 7061990 yjjV Escherichia coli O127:H6 str. E2348/69 deoxyribonuclease YjjV YP_002332121.1 4938155 D 574521 CDS YP_002332122.1 215489691 7061991 complement(4939151..4940014) 1 NC_011601.1 pyruvate formate lyase activating enzyme 4940014 yjjW 7061991 yjjW Escherichia coli O127:H6 str. E2348/69 pyruvate formate lyase activating enzyme YP_002332122.1 4939151 R 574521 CDS YP_002332123.1 215489692 7061992 complement(4939986..4941536) 1 NC_011601.1 hypothetical protein 4941536 yjjI 7061992 yjjI Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332123.1 4939986 R 574521 CDS YP_002332124.1 215489693 7061984 4941794..4942573 1 NC_011601.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 4942573 deoC 7061984 deoC Escherichia coli O127:H6 str. E2348/69 deoxyribose-phosphate aldolase YP_002332124.1 4941794 D 574521 CDS YP_002332125.1 215489694 7065009 4942651..4943973 1 NC_011601.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 4943973 deoA 7065009 deoA Escherichia coli O127:H6 str. E2348/69 thymidine phosphorylase YP_002332125.1 4942651 D 574521 CDS YP_002332126.1 215489695 7065007 4944025..4945248 1 NC_011601.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 4945248 deoB 7065007 deoB Escherichia coli O127:H6 str. E2348/69 phosphopentomutase YP_002332126.1 4944025 D 574521 CDS YP_002332127.1 215489696 7065008 4945305..4946024 1 NC_011601.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 4946024 deoD 7065008 deoD Escherichia coli O127:H6 str. E2348/69 purine nucleoside phosphorylase YP_002332127.1 4945305 D 574521 CDS YP_002332128.1 215489697 7065010 complement(4946185..4946448) 1 NC_011601.1 hypothetical protein 4946448 7065010 E2348C_4683 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332128.1 4946185 R 574521 CDS YP_002332129.1 215489698 7064951 complement(4946480..4947496) 1 NC_011601.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A 4947496 lplA 7064951 lplA Escherichia coli O127:H6 str. E2348/69 lipoate-protein ligase A YP_002332129.1 4946480 R 574521 CDS YP_002332130.1 215489699 7061567 complement(4947524..4948168) 1 NC_011601.1 hypothetical protein 4948168 ytjB 7061567 ytjB Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332130.1 4947524 R 574521 CDS YP_002332131.1 215489700 7063256 4948274..4949242 1 NC_011601.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 4949242 serB 7063256 serB Escherichia coli O127:H6 str. E2348/69 phosphoserine phosphatase YP_002332131.1 4948274 D 574521 CDS YP_002332132.1 215489701 7065367 4949291..4950673 1 NC_011601.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4950673 radA 7065367 radA Escherichia coli O127:H6 str. E2348/69 DNA repair protein RadA YP_002332132.1 4949291 D 574521 CDS YP_002332133.1 215489702 7063946 4950694..4951926 1 NC_011601.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 4951926 nadR 7063946 nadR Escherichia coli O127:H6 str. E2348/69 nicotinamide-nucleotide adenylyltransferase YP_002332133.1 4950694 D 574521 CDS YP_002332134.1 215489703 7060910 4952018..4952350 1 NC_011601.1 hypothetical protein 4952350 7060910 E2348C_4689 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332134.1 4952018 D 574521 CDS YP_002332135.1 215489704 7064952 4952352..4952636 1 NC_011601.1 regulatory protein 4952636 7064952 E2348C_4690 Escherichia coli O127:H6 str. E2348/69 regulatory protein YP_002332135.1 4952352 D 574521 CDS YP_002332136.1 215489705 7064953 complement(4952692..4954359) 1 NC_011601.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 4954359 yjjK 7064953 yjjK Escherichia coli O127:H6 str. E2348/69 ABC transporter ATP-binding protein YP_002332136.1 4952692 R 574521 CDS YP_002332137.1 215489706 7061985 4954695..4956632 1 NC_011601.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 4956632 slt 7061985 slt Escherichia coli O127:H6 str. E2348/69 lytic murein transglycosylase YP_002332137.1 4954695 D 574521 CDS YP_002332138.1 215489707 7062722 4956722..4957048 1 NC_011601.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 4957048 trpR 7062722 trpR Escherichia coli O127:H6 str. E2348/69 Trp operon repressor YP_002332138.1 4956722 D 574521 CDS YP_002332139.1 215489708 7062260 complement(4957121..4957648) 1 NC_011601.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase 4957648 yjjX 7062260 yjjX Escherichia coli O127:H6 str. E2348/69 NTPase YP_002332139.1 4957121 R 574521 CDS YP_002332140.1 215489709 7063257 complement(4958344..4959213) 1 NC_011601.1 DNA-binding transcriptional activator Rob 4959213 rob 7063257 rob Escherichia coli O127:H6 str. E2348/69 DNA-binding transcriptional activator Rob YP_002332140.1 4958344 R 574521 CDS YP_002332141.1 215489710 7061822 4959424..4959897 1 NC_011601.1 hypothetical protein 4959897 creA 7061822 creA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332141.1 4959424 D 574521 CDS YP_002332142.1 215489711 7062842 4959910..4960599 1 NC_011601.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 4960599 creB 7062842 creB Escherichia coli O127:H6 str. E2348/69 DNA-binding response regulator CreB YP_002332142.1 4959910 D 574521 CDS YP_002332143.1 215489712 7062843 4960599..4962023 1 NC_011601.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 4962023 creC 7062843 creC Escherichia coli O127:H6 str. E2348/69 sensory histidine kinase CreC YP_002332143.1 4960599 D 574521 CDS YP_002332144.1 215489713 7062845 complement(4963491..4964207) 1 NC_011601.1 two-component response regulator 4964207 arcA 7062845 arcA Escherichia coli O127:H6 str. E2348/69 two-component response regulator YP_002332144.1 4963491 R 574521 CDS YP_002332145.1 215489714 7061363 4964303..4964443 1 NC_011601.1 hypothetical protein 4964443 yjjY 7061363 yjjY Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332145.1 4964303 D 574521 CDS YP_002332146.1 215489715 7061994 4964843..4965529 1 NC_011601.1 member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 4965529 yjtD 7061994 yjtD Escherichia coli O127:H6 str. E2348/69 RNA methyltransferase YP_002332146.1 4964843 D 574521 CDS YP_002332147.1 215274579 7056255 141..956 1 NC_011602.1 dihydropteroate synthase 956 sulII 7056255 sulII Escherichia coli O127:H6 str. E2348/69 dihydropteroate synthase YP_002332147.1 141 D 574521 CDS YP_002332148.1 215274580 7056264 1017..1820 1 NC_011602.1 streptomycin phosphotransferase StrA 1820 strA 7056264 strA Escherichia coli O127:H6 str. E2348/69 streptomycin phosphotransferase StrA YP_002332148.1 1017 D 574521 CDS YP_002332149.1 215274581 7056262 1820..2656 1 NC_011602.1 streptomycin phosphotransferase StrB 2656 strB 7056262 strB Escherichia coli O127:H6 str. E2348/69 streptomycin phosphotransferase StrB YP_002332149.1 1820 D 574521 CDS YP_002332150.1 215274582 7056263 complement(2628..3167) 1 NC_011602.1 pseudogene, N-ter part of putative transposase; hypothetical protein 3167 7056263 E2348_P2_04 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332150.1 2628 R 574521 CDS YP_002332151.1 215274583 7056256 complement(3211..3600) 1 NC_011602.1 hypothetical protein 3600 7056256 E2348_P2_05 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332151.1 3211 R 574521 CDS YP_002332152.1 215274584 7056257 3770..4258 1 NC_011602.1 entry exclusion protein 1 4258 7056257 E2348_P2_06 Escherichia coli O127:H6 str. E2348/69 entry exclusion protein 1 YP_002332152.1 3770 D 574521 CDS YP_002332153.1 215274585 7056258 complement(4317..4592) 1 NC_011602.1 hypothetical protein 4592 7056258 E2348_P2_07 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332153.1 4317 R 574521 CDS YP_002332154.1 215274586 7056259 complement(4950..5099) 1 NC_011602.1 hypothetical protein 5099 7056259 E2348_P2_08 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332154.1 4950 R 574521 CDS YP_002332155.1 215274587 7056260 5224..5628 1 NC_011602.1 probable plasmid replication initiation protein 5628 7056260 E2348_P2_09 Escherichia coli O127:H6 str. E2348/69 probable plasmid replication initiation protein YP_002332155.1 5224 D 574521 CDS YP_002332156.1 215276193 7056380 275..1252 1 NC_011603.1 bind to repeated iterons in RepFIB; replication initiation protein 1252 repI 7056380 repI Escherichia coli O127:H6 str. E2348/69 replication initiation protein YP_002332156.1 275 D 574521 CDS YP_002332157.1 215276194 7056343 2646..3227 1 NC_011603.1 major pilin structural unit bundlin 3227 bfpA 7056343 bfpA Escherichia coli O127:H6 str. E2348/69 major pilin structural unit bundlin YP_002332157.1 2646 D 574521 CDS YP_002332158.1 215276195 7056319 3274..3675 1 NC_011603.1 lipoprotein 3675 bfpG 7056319 bfpG Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002332158.1 3274 D 574521 CDS YP_002332159.1 215276196 7056325 3682..5340 1 NC_011603.1 lipoprotein 5340 bfpB 7056325 bfpB Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002332159.1 3682 D 574521 CDS YP_002332160.1 215276197 7056320 5337..6545 1 NC_011603.1 hypothetical protein 6545 bfpC 7056320 bfpC Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332160.1 5337 D 574521 CDS YP_002332161.1 215276198 7056321 6523..7017 1 NC_011603.1 periplasmic protein 7017 bfpU 7056321 bfpU Escherichia coli O127:H6 str. E2348/69 periplasmic protein YP_002332161.1 6523 D 574521 CDS YP_002332162.1 215276199 7056331 7024..8631 1 NC_011603.1 nucleotide binding protein 8631 bfpD 7056331 bfpD Escherichia coli O127:H6 str. E2348/69 nucleotide binding protein YP_002332162.1 7024 D 574521 CDS YP_002332163.1 215276200 7056322 8638..9696 1 NC_011603.1 transmembrane protein 9696 bfpE 7056322 bfpE Escherichia coli O127:H6 str. E2348/69 transmembrane protein YP_002332163.1 8638 D 574521 CDS YP_002332164.1 215276201 7056323 9680..10675 1 NC_011603.1 nucleotide binding protein 10675 bfpF 7056323 bfpF Escherichia coli O127:H6 str. E2348/69 nucleotide binding protein YP_002332164.1 9680 D 574521 CDS YP_002332165.1 215276202 7056324 10682..11431 1 NC_011603.1 prepilin peptidase 11431 bfpP 7056324 bfpP Escherichia coli O127:H6 str. E2348/69 prepilin peptidase YP_002332165.1 10682 D 574521 CDS YP_002332166.1 215276203 7056330 11413..11859 1 NC_011603.1 lipoprotein 11859 bfpH 7056330 bfpH Escherichia coli O127:H6 str. E2348/69 lipoprotein YP_002332166.1 11413 D 574521 CDS YP_002332167.1 215276204 7056326 11880..12425 1 NC_011603.1 prepilin 12425 bfpI 7056326 bfpI Escherichia coli O127:H6 str. E2348/69 prepilin YP_002332167.1 11880 D 574521 CDS YP_002332168.1 215276205 7056327 12422..12973 1 NC_011603.1 prepilin 12973 bfpJ 7056327 bfpJ Escherichia coli O127:H6 str. E2348/69 prepilin YP_002332168.1 12422 D 574521 CDS YP_002332169.1 215276206 7056328 12963..13451 1 NC_011603.1 prepilin 13451 bfpK 7056328 bfpK Escherichia coli O127:H6 str. E2348/69 prepilin YP_002332169.1 12963 D 574521 CDS YP_002332170.1 215276207 7056329 13454..13903 1 NC_011603.1 inner membrane protein 13903 bfpL 7056329 bfpL Escherichia coli O127:H6 str. E2348/69 inner membrane protein YP_002332170.1 13454 D 574521 CDS YP_002332171.1 215276208 7056300 complement(15490..16356) 1 NC_011603.1 transposase Orf2 of ISEc17 16356 7056300 E2348_P1_018 Escherichia coli O127:H6 str. E2348/69 transposase Orf2 of ISEc17 YP_002332171.1 15490 R 574521 CDS YP_002332172.1 215276209 7056267 complement(16353..16652) 1 NC_011603.1 transposase Orf1 of ISEc17 16652 7056267 E2348_P1_019 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of ISEc17 YP_002332172.1 16353 R 574521 CDS YP_002332173.1 215276210 7056301 17176..18000 1 NC_011603.1 transcriptional activator of the bfp operon 18000 perA 7056301 perA Escherichia coli O127:H6 str. E2348/69 transcriptional activator of the bfp operon YP_002332173.1 17176 D 574521 CDS YP_002332174.1 215276211 7056339 18048..18437 1 NC_011603.1 transcriptional regulator 18437 perB 7056339 perB Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002332174.1 18048 D 574521 CDS YP_002332175.1 215276212 7056340 18487..18756 1 NC_011603.1 transcriptional regulator 18756 perC 7056340 perC Escherichia coli O127:H6 str. E2348/69 transcriptional regulator YP_002332175.1 18487 D 574521 CDS YP_002332176.1 215276213 7056272 complement(29608..29895) 1 NC_011603.1 hypothetical protein 29895 7056272 E2348_P1_033 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332176.1 29608 R 574521 CDS YP_002332177.1 215276214 7056273 complement(29892..30143) 1 NC_011603.1 hypothetical protein 30143 7056273 E2348_P1_034 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332177.1 29892 R 574521 CDS YP_002332178.1 215276215 7056274 complement(31108..31965) 1 NC_011603.1 RepA; replication protein 31965 repA 7056274 repA Escherichia coli O127:H6 str. E2348/69 replication protein YP_002332178.1 31108 R 574521 CDS YP_002332179.1 215276216 7056297 complement(32279..32527) 1 NC_011603.1 replication protein 32527 copB 7056297 copB Escherichia coli O127:H6 str. E2348/69 replication protein YP_002332179.1 32279 R 574521 CDS YP_002332180.1 215276217 7056334 complement(32811..32960) 1 NC_011603.1 post-segregational killing toxin 32960 srnB 7056334 srnB Escherichia coli O127:H6 str. E2348/69 post-segregational killing toxin YP_002332180.1 32811 R 574521 CDS YP_002332181.1 215276218 7056308 33149..34522 1 NC_011603.1 transposase of ISEc13 34522 7056308 E2348_P1_038 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002332181.1 33149 D 574521 CDS YP_002332182.1 215276219 7056275 complement(34555..35112) 1 NC_011603.1 conjugal transfer fertility inhibition protein FinO 35112 finO 7056275 finO Escherichia coli O127:H6 str. E2348/69 conjugal transfer fertility inhibition protein FinO YP_002332182.1 34555 R 574521 CDS YP_002332183.1 215276220 7056335 complement(35215..36075) 1 NC_011603.1 hypothetical protein 36075 7056335 E2348_P1_040 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332183.1 35215 R 574521 CDS YP_002332184.1 215276221 7056276 complement(36134..36880) 1 NC_011603.1 conjugal transfer pilus acetylation protein TraX 36880 traX 7056276 traX Escherichia coli O127:H6 str. E2348/69 conjugal transfer pilus acetylation protein TraX YP_002332184.1 36134 R 574521 CDS YP_002332185.1 215276222 7056369 complement(36900..42170) 1 NC_011603.1 cleaves origin of transfer and unwinds; oriT relaxase; conjugal transfer nickase/helicase TraI 42170 traI 7056369 traI Escherichia coli O127:H6 str. E2348/69 conjugal transfer nickase/helicase TraI YP_002332185.1 36900 R 574521 CDS YP_002332186.1 215276223 7056355 42252..42479 1 NC_011603.1 post-segregational killing toxin 42479 mvpT 7056355 mvpT Escherichia coli O127:H6 str. E2348/69 post-segregational killing toxin YP_002332186.1 42252 D 574521 CDS YP_002332187.1 215276224 7056338 42479..42877 1 NC_011603.1 stability determinant protein; plasmid maintenance protein 42877 mvpA 7056338 mvpA Escherichia coli O127:H6 str. E2348/69 plasmid maintenance protein YP_002332187.1 42479 D 574521 CDS YP_002332188.1 215276225 7056337 complement(42886..45039) 1 NC_011603.1 type IV secretion system coupling protein; similar to F plasmid TraD; conjugal transfer protein TraD 45039 traD 7056337 traD Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TraD YP_002332188.1 42886 R 574521 CDS YP_002332189.1 215276226 7056350 complement(45292..46023) 1 NC_011603.1 conjugal transfer surface exclusion protein TraT 46023 traT 7056350 traT Escherichia coli O127:H6 str. E2348/69 conjugal transfer surface exclusion protein TraT YP_002332189.1 45292 R 574521 CDS YP_002332190.1 215276227 7056365 complement(46037..46546) 1 NC_011603.1 conjugal transfer entry exclusion protein TraS 46546 traS 7056365 traS Escherichia coli O127:H6 str. E2348/69 conjugal transfer entry exclusion protein TraS YP_002332190.1 46037 R 574521 CDS YP_002332191.1 215276228 7056364 complement(46543..49368) 1 NC_011603.1 conjugal transfer mating pair stabilization protein TraG 49368 traG 7056364 traG Escherichia coli O127:H6 str. E2348/69 conjugal transfer mating pair stabilization protein TraG YP_002332191.1 46543 R 574521 CDS YP_002332192.1 215276229 7056353 complement(49365..50738) 1 NC_011603.1 conjugal transfer pilus assembly protein TraH 50738 traH 7056353 traH Escherichia coli O127:H6 str. E2348/69 conjugal transfer pilus assembly protein TraH YP_002332192.1 49365 R 574521 CDS YP_002332193.1 215276230 7056354 complement(50738..51118) 1 NC_011603.1 conjugal transfer protein TrbF 51118 trbF 7056354 trbF Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TrbF YP_002332193.1 50738 R 574521 CDS YP_002332194.1 215276231 7056376 complement(51105..51446) 1 NC_011603.1 conjugal transfer protein TrbJ 51446 trbJ 7056376 trbJ Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TrbJ YP_002332194.1 51105 R 574521 CDS YP_002332195.1 215276232 7056379 complement(51376..51921) 1 NC_011603.1 conjugal transfer protein TrbB 51921 trbB 7056379 trbB Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TrbB YP_002332195.1 51376 R 574521 CDS YP_002332196.1 215276233 7056372 complement(51908..52192) 1 NC_011603.1 conjugal transfer pilin chaperone TraQ 52192 traQ 7056372 traQ Escherichia coli O127:H6 str. E2348/69 conjugal transfer pilin chaperone TraQ YP_002332196.1 51908 R 574521 CDS YP_002332197.1 215276234 7056362 52273..52587 1 NC_011603.1 hypothetical protein 52587 artA 7056362 artA Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332197.1 52273 D 574521 CDS YP_002332198.1 215276235 7056318 complement(52589..52921) 1 NC_011603.1 conjugal transfer protein TrbA 52921 trbA 7056318 trbA Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TrbA YP_002332198.1 52589 R 574521 CDS YP_002332199.1 215276236 7056371 complement(52952..53713) 1 NC_011603.1 type IV secretion system pilus assembly protein; similar to F plasmid TraF; conjugal pilus assembly protein TraF 53713 traF 7056371 traF Escherichia coli O127:H6 str. E2348/69 conjugal pilus assembly protein TraF YP_002332199.1 52952 R 574521 CDS YP_002332200.1 215276237 7056352 complement(53688..53948) 1 NC_011603.1 conjugal transfer protein TrbE 53948 trbE 7056352 trbE Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TrbE YP_002332200.1 53688 R 574521 CDS YP_002332201.1 215276238 7056375 complement(53973..55781) 1 NC_011603.1 TraN; TrhN; involved in stabilizing mating pairs during plasmid conjugation; F plasmid TraN appears to recognize OmpA in the recipient cell; conjugal transfer mating pair stabilization protein TraN 55781 traN 7056375 traN Escherichia coli O127:H6 str. E2348/69 conjugal transfer mating pair stabilization protein TraN YP_002332201.1 53973 R 574521 CDS YP_002332202.1 215276239 7056360 complement(55778..56416) 1 NC_011603.1 conjugal transfer pilus assembly protein TrbC 56416 trbC 7056360 trbC Escherichia coli O127:H6 str. E2348/69 conjugal transfer pilus assembly protein TrbC YP_002332202.1 55778 R 574521 CDS YP_002332203.1 215276240 7056373 complement(56425..57417) 1 NC_011603.1 conjugal transfer pilus assembly protein TraU 57417 traU 7056373 traU Escherichia coli O127:H6 str. E2348/69 conjugal transfer pilus assembly protein TraU YP_002332203.1 56425 R 574521 CDS YP_002332204.1 215276241 7056366 complement(57414..58046) 1 NC_011603.1 conjugal transfer pilus assembly protein TraW 58046 traW 7056366 traW Escherichia coli O127:H6 str. E2348/69 conjugal transfer pilus assembly protein TraW YP_002332204.1 57414 R 574521 CDS YP_002332205.1 215276242 7056368 complement(58043..58429) 1 NC_011603.1 conjugal transfer protein TrbI 58429 trbI 7056368 trbI Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TrbI YP_002332205.1 58043 R 574521 CDS YP_002332206.1 215276243 7056378 complement(58426..61053) 1 NC_011603.1 similar to VirB4; conjugal transfer ATP-binding protein TraC 61053 traC 7056378 traC Escherichia coli O127:H6 str. E2348/69 conjugal transfer ATP-binding protein TraC YP_002332206.1 58426 R 574521 CDS YP_002332207.1 215276244 7056349 complement(61213..61434) 1 NC_011603.1 conjugal transfer protein TraR 61434 traR 7056349 traR Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TraR YP_002332207.1 61213 R 574521 CDS YP_002332208.1 215276245 7056363 complement(61569..62084) 1 NC_011603.1 conjugal transfer protein TraV 62084 traV 7056363 traV Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TraV YP_002332208.1 61569 R 574521 CDS YP_002332209.1 215276246 7056367 complement(62081..62332) 1 NC_011603.1 conjugal transfer protein TrbG 62332 trbG 7056367 trbG Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TrbG YP_002332209.1 62081 R 574521 CDS YP_002332210.1 215276247 7056377 complement(62325..62645) 1 NC_011603.1 similar to traD of F plasmid, 96% identity in 61 aa overlap but with C-terminal extension; conjugal transfer protein TrbD 62645 trbD 7056377 trbD Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TrbD YP_002332210.1 62325 R 574521 CDS YP_002332211.1 215276248 7056374 complement(62632..63222) 1 NC_011603.1 conjugal transfer protein TraP 63222 traP 7056374 traP Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TraP YP_002332211.1 62632 R 574521 CDS YP_002332212.1 215276249 7056361 complement(63212..64639) 1 NC_011603.1 conjugal transfer pilus assembly protein TraB 64639 traB 7056361 traB Escherichia coli O127:H6 str. E2348/69 conjugal transfer pilus assembly protein TraB YP_002332212.1 63212 R 574521 CDS YP_002332213.1 215276250 7056348 complement(64639..65367) 1 NC_011603.1 conjugal transfer protein TraK 65367 traK 7056348 traK Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TraK YP_002332213.1 64639 R 574521 CDS YP_002332214.1 215276251 7056357 complement(65354..65920) 1 NC_011603.1 conjugal transfer pilus assembly protein TraE 65920 traE 7056357 traE Escherichia coli O127:H6 str. E2348/69 conjugal transfer pilus assembly protein TraE YP_002332214.1 65354 R 574521 CDS YP_002332215.1 215276252 7056351 complement(65942..66253) 1 NC_011603.1 conjugal transfer pilus assembly protein TraL 66253 traL 7056351 traL Escherichia coli O127:H6 str. E2348/69 conjugal transfer pilus assembly protein TraL YP_002332215.1 65942 R 574521 CDS YP_002332216.1 215276253 7056358 complement(66268..66633) 1 NC_011603.1 conjugal transfer pilin subunit TraA 66633 traA 7056358 traA Escherichia coli O127:H6 str. E2348/69 conjugal transfer pilin subunit TraA YP_002332216.1 66268 R 574521 CDS YP_002332217.1 215276254 7056347 complement(66667..66894) 1 NC_011603.1 conjugal transfer protein TraY 66894 traY 7056347 traY Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TraY YP_002332217.1 66667 R 574521 CDS YP_002332218.1 215276255 7056370 complement(66989..67675) 1 NC_011603.1 transcriptional activator 67675 traJ 7056370 traJ Escherichia coli O127:H6 str. E2348/69 transcriptional activator YP_002332218.1 66989 R 574521 CDS YP_002332219.1 215276256 7056298 complement(67865..68248) 1 NC_011603.1 conjugal transfer protein TraM 68248 traM 7056298 traM Escherichia coli O127:H6 str. E2348/69 conjugal transfer protein TraM YP_002332219.1 67865 R 574521 CDS YP_002332220.1 215276257 7056359 68674..69183 1 NC_011603.1 similar to ygfA of F plasmid, 99% identity in 169 aa overlap; lytic transglycosylase 69183 7056359 E2348_P1_077 Escherichia coli O127:H6 str. E2348/69 lytic transglycosylase YP_002332220.1 68674 D 574521 CDS YP_002332221.1 215276258 7056277 complement(69479..70300) 1 NC_011603.1 similar to ygeB of F plasmid, 98% identity in 273 aa overlap; hypothetical protein 70300 7056277 E2348_P1_078 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332221.1 69479 R 574521 CDS YP_002332222.1 215276259 7056309 complement(71571..72944) 1 NC_011603.1 transposase of ISEc13 72944 7056309 E2348_P1_081 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 YP_002332222.1 71571 R 574521 CDS YP_002332223.1 215276260 7056281 complement(73574..74935) 1 NC_011603.1 hypothetical protein 74935 7056281 E2348_P1_083 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332223.1 73574 R 574521 CDS YP_002332224.1 215276261 7056282 74939..75199 1 NC_011603.1 hypothetical protein 75199 7056282 E2348_P1_084 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332224.1 74939 D 574521 CDS YP_002332225.1 215276262 7056283 75635..76057 1 NC_011603.1 conserved predicted protein 76057 7056283 E2348_P1_085 Escherichia coli O127:H6 str. E2348/69 conserved predicted protein YP_002332225.1 75635 D 574521 CDS YP_002332226.1 215276263 7056284 complement(76395..76814) 1 NC_011603.1 hypothetical protein 76814 7056284 E2348_P1_086 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332226.1 76395 R 574521 CDS YP_002332227.1 215276264 7056285 complement(76861..77286) 1 NC_011603.1 hypothetical protein 77286 7056285 E2348_P1_087 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332227.1 76861 R 574521 CDS YP_002332228.1 215276265 7056311 complement(78922..80073) 1 NC_011603.1 transposase of IS30 80073 7056311 E2348_P1_090 Escherichia coli O127:H6 str. E2348/69 transposase of IS30 YP_002332228.1 78922 R 574521 CDS YP_002332229.1 215276266 7056313 81016..82092 1 NC_011603.1 transposase of ISEc13 of IS110 family 82092 7056313 E2348_P1_092 Escherichia coli O127:H6 str. E2348/69 transposase of ISEc13 of IS110 family YP_002332229.1 81016 D 574521 CDS YP_002332230.1 215276267 7056288 83582..85042 1 NC_011603.1 putative glutamate:gamma-aminobutyrate antiporter 85042 7056288 E2348_P1_096 Escherichia coli O127:H6 str. E2348/69 putative glutamate:gamma-aminobutyrate antiporter YP_002332230.1 83582 D 574521 CDS YP_002332231.1 215276268 7056289 85076..85885 1 NC_011603.1 putative glutamate racemase 85885 7056289 E2348_P1_097 Escherichia coli O127:H6 str. E2348/69 putative glutamate racemase YP_002332231.1 85076 D 574521 CDS YP_002332232.1 215276269 7056316 complement(86004..86399) 1 NC_011603.1 transposase Orf1 of IS1N 86399 7056316 E2348_P1_098 Escherichia coli O127:H6 str. E2348/69 transposase Orf1 of IS1N YP_002332232.1 86004 R 574521 CDS YP_002332233.1 215276270 7056290 complement(86426..86698) 1 NC_011603.1 transposase Orf2 of IS1N 86698 7056290 E2348_P1_099 Escherichia coli O127:H6 str. E2348/69 transposase Orf2 of IS1N YP_002332233.1 86426 R 574521 CDS YP_002332234.1 215276271 7056336 complement(88216..88608) 1 NC_011603.1 plasmid stability protein 88608 stbB 7056336 stbB Escherichia coli O127:H6 str. E2348/69 plasmid stability protein YP_002332234.1 88216 R 574521 CDS YP_002332235.1 215276272 7056346 complement(88613..89584) 1 NC_011603.1 plasmid stability protein 89584 stbA 7056346 stbA Escherichia coli O127:H6 str. E2348/69 plasmid stability protein YP_002332235.1 88613 R 574521 CDS YP_002332236.1 215276273 7056345 89813..90457 1 NC_011603.1 ParA-like protein, putative partitioning protein 90457 7056345 E2348_P1_103 Escherichia coli O127:H6 str. E2348/69 ParA-like protein, putative partitioning protein YP_002332236.1 89813 D 574521 CDS YP_002332237.1 215276274 7056292 90451..90726 1 NC_011603.1 hypothetical protein 90726 7056292 E2348_P1_104 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332237.1 90451 D 574521 CDS YP_002332238.1 215276275 7056293 complement(90864..91673) 1 NC_011603.1 putative resolvase 91673 rsvB 7056293 rsvB Escherichia coli O127:H6 str. E2348/69 putative resolvase YP_002332238.1 90864 R 574521 CDS YP_002332239.1 215276276 7056344 complement(91674..91979) 1 NC_011603.1 controlled cell death protein; post-segregation toxin; toxin addiction system; plasmid maintenance protein CcdB 91979 ccdB 7056344 ccdB Escherichia coli O127:H6 str. E2348/69 plasmid maintenance protein CcdB YP_002332239.1 91674 R 574521 CDS YP_002332240.1 215276277 7056333 complement(91981..92199) 1 NC_011603.1 plasmid maintenance protein CcdA 92199 ccdA 7056333 ccdA Escherichia coli O127:H6 str. E2348/69 plasmid maintenance protein CcdA YP_002332240.1 91981 R 574521 CDS YP_002332241.1 215276278 7056332 92913..95534 1 NC_011603.1 hypothetical protein 95534 7056332 E2348_P1_108 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332241.1 92913 D 574521 CDS YP_002332242.1 215276279 7056294 95733..95963 1 NC_011603.1 VagC-like protein, putative plasmid maintenance protein 95963 7056294 E2348_P1_109 Escherichia coli O127:H6 str. E2348/69 VagC-like protein, putative plasmid maintenance protein YP_002332242.1 95733 D 574521 CDS YP_002332243.1 215276280 7056295 95960..96310 1 NC_011603.1 VagD-like protein, putative plasmid maintenance protein 96310 7056295 E2348_P1_110 Escherichia coli O127:H6 str. E2348/69 VagD-like protein, putative plasmid maintenance protein YP_002332243.1 95960 D 574521 CDS YP_002332244.1 215276281 7056317 complement(96550..97080) 1 NC_011603.1 hypothetical protein 97080 7056317 E2348_P1_111 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332244.1 96550 R 574521 CDS YP_002332245.1 215276282 7056296 complement(97084..97353) 1 NC_011603.1 hypothetical protein 97353 7056296 E2348_P1_112 Escherichia coli O127:H6 str. E2348/69 hypothetical protein YP_002332245.1 97084 R 574521 CDS