-- dump date 20140619_085630 -- class Genbank::misc_feature -- table misc_feature_note -- id note 574521000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 574521000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 574521000003 putative catalytic residues [active] 574521000004 putative nucleotide binding site [chemical binding]; other site 574521000005 putative aspartate binding site [chemical binding]; other site 574521000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 574521000007 dimer interface [polypeptide binding]; other site 574521000008 putative threonine allosteric regulatory site; other site 574521000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 574521000010 putative threonine allosteric regulatory site; other site 574521000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 574521000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 574521000013 homoserine kinase; Region: thrB; TIGR00191 574521000014 Protein of unknown function; Region: YhfT; pfam10797 574521000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 574521000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 574521000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 574521000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521000019 catalytic residue [active] 574521000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 574521000021 hypothetical protein; Validated; Region: PRK02101 574521000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 574521000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 574521000024 transaldolase-like protein; Provisional; Region: PTZ00411 574521000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 574521000026 active site 574521000027 dimer interface [polypeptide binding]; other site 574521000028 catalytic residue [active] 574521000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 574521000030 MPT binding site; other site 574521000031 trimer interface [polypeptide binding]; other site 574521000032 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521000033 hypothetical protein; Provisional; Region: PRK10659 574521000034 hypothetical protein; Provisional; Region: PRK10236 574521000035 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 574521000036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 574521000037 hypothetical protein; Provisional; Region: PRK10154 574521000038 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 574521000039 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 574521000040 nucleotide binding site [chemical binding]; other site 574521000041 NEF interaction site [polypeptide binding]; other site 574521000042 SBD interface [polypeptide binding]; other site 574521000043 chaperone protein DnaJ; Provisional; Region: PRK10767 574521000044 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 574521000045 HSP70 interaction site [polypeptide binding]; other site 574521000046 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 574521000047 substrate binding site [polypeptide binding]; other site 574521000048 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 574521000049 Zn binding sites [ion binding]; other site 574521000050 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 574521000051 dimer interface [polypeptide binding]; other site 574521000052 Hok/gef family; Region: HOK_GEF; pfam01848 574521000053 Hok/gef family; Region: HOK_GEF; pfam01848 574521000054 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 574521000055 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 574521000056 Sulfatase; Region: Sulfatase; pfam00884 574521000057 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 574521000058 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 574521000059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521000060 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 574521000061 putative dimerization interface [polypeptide binding]; other site 574521000062 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 574521000063 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 574521000064 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 574521000065 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 574521000066 active site 574521000067 Riboflavin kinase; Region: Flavokinase; smart00904 574521000068 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 574521000069 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 574521000070 HIGH motif; other site 574521000071 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 574521000072 active site 574521000073 KMSKS motif; other site 574521000074 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 574521000075 tRNA binding surface [nucleotide binding]; other site 574521000076 anticodon binding site; other site 574521000077 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 574521000078 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 574521000079 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 574521000080 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 574521000081 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 574521000082 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 574521000083 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 574521000084 active site 574521000085 tetramer interface [polypeptide binding]; other site 574521000086 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 574521000087 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 574521000088 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 574521000089 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 574521000090 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 574521000091 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 574521000092 catalytic site [active] 574521000093 subunit interface [polypeptide binding]; other site 574521000094 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 574521000095 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 574521000096 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 574521000097 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 574521000098 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 574521000099 ATP-grasp domain; Region: ATP-grasp_4; cl17255 574521000100 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 574521000101 IMP binding site; other site 574521000102 dimer interface [polypeptide binding]; other site 574521000103 interdomain contacts; other site 574521000104 partial ornithine binding site; other site 574521000105 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 574521000106 carnitine operon protein CaiE; Provisional; Region: PRK13627 574521000107 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 574521000108 putative trimer interface [polypeptide binding]; other site 574521000109 putative metal binding site [ion binding]; other site 574521000110 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 574521000111 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 574521000112 substrate binding site [chemical binding]; other site 574521000113 oxyanion hole (OAH) forming residues; other site 574521000114 trimer interface [polypeptide binding]; other site 574521000115 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 574521000116 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 574521000117 acyl-activating enzyme (AAE) consensus motif; other site 574521000118 putative AMP binding site [chemical binding]; other site 574521000119 putative active site [active] 574521000120 putative CoA binding site [chemical binding]; other site 574521000121 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 574521000122 CoA-transferase family III; Region: CoA_transf_3; pfam02515 574521000123 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 574521000124 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 574521000125 active site 574521000126 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 574521000127 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 574521000128 Ligand binding site [chemical binding]; other site 574521000129 Electron transfer flavoprotein domain; Region: ETF; pfam01012 574521000130 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 574521000131 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 574521000132 Ligand binding site [chemical binding]; other site 574521000133 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 574521000134 putative oxidoreductase FixC; Provisional; Region: PRK10157 574521000135 ferredoxin-like protein FixX; Provisional; Region: PRK15449 574521000136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521000137 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 574521000138 putative substrate translocation pore; other site 574521000139 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 574521000140 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 574521000141 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 574521000142 TrkA-N domain; Region: TrkA_N; pfam02254 574521000143 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 574521000144 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 574521000145 folate binding site [chemical binding]; other site 574521000146 NADP+ binding site [chemical binding]; other site 574521000147 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 574521000148 CcdB protein; Region: CcdB; pfam01845 574521000149 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 574521000150 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 574521000151 active site 574521000152 metal binding site [ion binding]; metal-binding site 574521000153 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 574521000154 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 574521000155 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 574521000156 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 574521000157 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 574521000158 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 574521000159 SurA N-terminal domain; Region: SurA_N; pfam09312 574521000160 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 574521000161 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 574521000162 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 574521000163 OstA-like protein; Region: OstA; pfam03968 574521000164 Organic solvent tolerance protein; Region: OstA_C; pfam04453 574521000165 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 574521000166 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 574521000167 putative metal binding site [ion binding]; other site 574521000168 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 574521000169 HSP70 interaction site [polypeptide binding]; other site 574521000170 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 574521000171 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 574521000172 active site 574521000173 ATP-dependent helicase HepA; Validated; Region: PRK04914 574521000174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 574521000175 ATP binding site [chemical binding]; other site 574521000176 putative Mg++ binding site [ion binding]; other site 574521000177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521000178 nucleotide binding region [chemical binding]; other site 574521000179 ATP-binding site [chemical binding]; other site 574521000180 DNA polymerase II; Reviewed; Region: PRK05762 574521000181 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 574521000182 active site 574521000183 catalytic site [active] 574521000184 substrate binding site [chemical binding]; other site 574521000185 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 574521000186 active site 574521000187 metal-binding site 574521000188 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 574521000189 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 574521000190 intersubunit interface [polypeptide binding]; other site 574521000191 active site 574521000192 Zn2+ binding site [ion binding]; other site 574521000193 L-arabinose isomerase; Provisional; Region: PRK02929 574521000194 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 574521000195 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 574521000196 trimer interface [polypeptide binding]; other site 574521000197 putative substrate binding site [chemical binding]; other site 574521000198 putative metal binding site [ion binding]; other site 574521000199 ribulokinase; Provisional; Region: PRK04123 574521000200 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 574521000201 N- and C-terminal domain interface [polypeptide binding]; other site 574521000202 active site 574521000203 MgATP binding site [chemical binding]; other site 574521000204 catalytic site [active] 574521000205 metal binding site [ion binding]; metal-binding site 574521000206 carbohydrate binding site [chemical binding]; other site 574521000207 homodimer interface [polypeptide binding]; other site 574521000208 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 574521000209 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 574521000210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521000211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521000212 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 574521000213 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 574521000214 putative DNA binding site [nucleotide binding]; other site 574521000215 putative Zn2+ binding site [ion binding]; other site 574521000216 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 574521000217 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 574521000218 substrate binding site [chemical binding]; other site 574521000219 dimer interface [polypeptide binding]; other site 574521000220 ATP binding site [chemical binding]; other site 574521000221 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 574521000222 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 574521000223 inhibitor site; inhibition site 574521000224 active site 574521000225 dimer interface [polypeptide binding]; other site 574521000226 catalytic residue [active] 574521000227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 574521000228 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 574521000229 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 574521000230 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 574521000231 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 574521000232 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 574521000233 Walker A/P-loop; other site 574521000234 ATP binding site [chemical binding]; other site 574521000235 Q-loop/lid; other site 574521000236 ABC transporter signature motif; other site 574521000237 Walker B; other site 574521000238 D-loop; other site 574521000239 H-loop/switch region; other site 574521000240 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 574521000241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521000242 dimer interface [polypeptide binding]; other site 574521000243 conserved gate region; other site 574521000244 putative PBP binding loops; other site 574521000245 ABC-ATPase subunit interface; other site 574521000246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521000247 dimer interface [polypeptide binding]; other site 574521000248 conserved gate region; other site 574521000249 putative PBP binding loops; other site 574521000250 ABC-ATPase subunit interface; other site 574521000251 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 574521000252 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 574521000253 transcriptional regulator SgrR; Provisional; Region: PRK13626 574521000254 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 574521000255 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 574521000256 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 574521000257 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 574521000258 substrate binding site [chemical binding]; other site 574521000259 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 574521000260 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 574521000261 substrate binding site [chemical binding]; other site 574521000262 ligand binding site [chemical binding]; other site 574521000263 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 574521000264 tartrate dehydrogenase; Region: TTC; TIGR02089 574521000265 2-isopropylmalate synthase; Validated; Region: PRK00915 574521000266 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 574521000267 active site 574521000268 catalytic residues [active] 574521000269 metal binding site [ion binding]; metal-binding site 574521000270 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 574521000271 leu operon leader peptide; Provisional; Region: PRK09925 574521000272 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 574521000273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521000274 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 574521000275 putative substrate binding pocket [chemical binding]; other site 574521000276 putative dimerization interface [polypeptide binding]; other site 574521000277 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 574521000278 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 574521000279 PYR/PP interface [polypeptide binding]; other site 574521000280 dimer interface [polypeptide binding]; other site 574521000281 TPP binding site [chemical binding]; other site 574521000282 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 574521000283 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 574521000284 TPP-binding site [chemical binding]; other site 574521000285 dimer interface [polypeptide binding]; other site 574521000286 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 574521000287 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 574521000288 putative valine binding site [chemical binding]; other site 574521000289 dimer interface [polypeptide binding]; other site 574521000290 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 574521000291 similar to fruR leader peptide 574521000292 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 574521000293 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521000294 DNA binding site [nucleotide binding] 574521000295 domain linker motif; other site 574521000296 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 574521000297 dimerization interface [polypeptide binding]; other site 574521000298 ligand binding site [chemical binding]; other site 574521000299 mraZ protein; Region: TIGR00242 574521000300 MraZ protein; Region: MraZ; pfam02381 574521000301 MraZ protein; Region: MraZ; pfam02381 574521000302 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 574521000303 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 574521000304 cell division protein FtsL; Provisional; Region: PRK10772 574521000305 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 574521000306 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 574521000307 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 574521000308 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 574521000309 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 574521000310 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 574521000311 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 574521000312 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 574521000313 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 574521000314 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 574521000315 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 574521000316 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 574521000317 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 574521000318 Mg++ binding site [ion binding]; other site 574521000319 putative catalytic motif [active] 574521000320 putative substrate binding site [chemical binding]; other site 574521000321 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 574521000322 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 574521000323 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 574521000324 cell division protein FtsW; Provisional; Region: PRK10774 574521000325 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 574521000326 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 574521000327 active site 574521000328 homodimer interface [polypeptide binding]; other site 574521000329 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 574521000330 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 574521000331 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 574521000332 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 574521000333 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 574521000334 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 574521000335 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 574521000336 cell division protein FtsQ; Provisional; Region: PRK10775 574521000337 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 574521000338 Cell division protein FtsQ; Region: FtsQ; pfam03799 574521000339 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 574521000340 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 574521000341 Cell division protein FtsA; Region: FtsA; pfam14450 574521000342 cell division protein FtsZ; Validated; Region: PRK09330 574521000343 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 574521000344 nucleotide binding site [chemical binding]; other site 574521000345 SulA interaction site; other site 574521000346 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 574521000347 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 574521000348 SecA regulator SecM; Provisional; Region: PRK02943 574521000349 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 574521000350 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 574521000351 SEC-C motif; Region: SEC-C; pfam02810 574521000352 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 574521000353 active site 574521000354 8-oxo-dGMP binding site [chemical binding]; other site 574521000355 nudix motif; other site 574521000356 metal binding site [ion binding]; metal-binding site 574521000357 DNA gyrase inhibitor; Reviewed; Region: PRK00418 574521000358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 574521000359 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 574521000360 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 574521000361 CoA-binding site [chemical binding]; other site 574521000362 ATP-binding [chemical binding]; other site 574521000363 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 574521000364 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 574521000365 active site 574521000366 type IV pilin biogenesis protein; Provisional; Region: PRK10573 574521000367 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 574521000368 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 574521000369 hypothetical protein; Provisional; Region: PRK10436 574521000370 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 574521000371 Walker A motif; other site 574521000372 ATP binding site [chemical binding]; other site 574521000373 Walker B motif; other site 574521000374 putative major pilin subunit; Provisional; Region: PRK10574 574521000375 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 574521000376 Pilin (bacterial filament); Region: Pilin; pfam00114 574521000377 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 574521000378 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 574521000379 dimerization interface [polypeptide binding]; other site 574521000380 active site 574521000381 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 574521000382 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 574521000383 amidase catalytic site [active] 574521000384 Zn binding residues [ion binding]; other site 574521000385 substrate binding site [chemical binding]; other site 574521000386 regulatory protein AmpE; Provisional; Region: PRK10987 574521000387 aromatic amino acid transporter; Provisional; Region: PRK10238 574521000388 Transcriptional regulators [Transcription]; Region: FadR; COG2186 574521000389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521000390 DNA-binding site [nucleotide binding]; DNA binding site 574521000391 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 574521000392 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 574521000393 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 574521000394 dimer interface [polypeptide binding]; other site 574521000395 TPP-binding site [chemical binding]; other site 574521000396 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 574521000397 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 574521000398 E3 interaction surface; other site 574521000399 lipoyl attachment site [posttranslational modification]; other site 574521000400 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 574521000401 E3 interaction surface; other site 574521000402 lipoyl attachment site [posttranslational modification]; other site 574521000403 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 574521000404 E3 interaction surface; other site 574521000405 lipoyl attachment site [posttranslational modification]; other site 574521000406 e3 binding domain; Region: E3_binding; pfam02817 574521000407 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 574521000408 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 574521000409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 574521000410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521000411 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 574521000412 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 574521000413 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 574521000414 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 574521000415 substrate binding site [chemical binding]; other site 574521000416 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 574521000417 substrate binding site [chemical binding]; other site 574521000418 ligand binding site [chemical binding]; other site 574521000419 hypothetical protein; Provisional; Region: PRK05248 574521000420 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 574521000421 spermidine synthase; Provisional; Region: PRK00811 574521000422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521000423 S-adenosylmethionine binding site [chemical binding]; other site 574521000424 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 574521000425 multicopper oxidase; Provisional; Region: PRK10965 574521000426 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 574521000427 Multicopper oxidase; Region: Cu-oxidase; pfam00394 574521000428 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 574521000429 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 574521000430 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 574521000431 Trp docking motif [polypeptide binding]; other site 574521000432 putative active site [active] 574521000433 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 574521000434 active site 574521000435 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 574521000436 active site clefts [active] 574521000437 zinc binding site [ion binding]; other site 574521000438 dimer interface [polypeptide binding]; other site 574521000439 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 574521000440 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 574521000441 Walker A/P-loop; other site 574521000442 ATP binding site [chemical binding]; other site 574521000443 Q-loop/lid; other site 574521000444 ABC transporter signature motif; other site 574521000445 Walker B; other site 574521000446 D-loop; other site 574521000447 H-loop/switch region; other site 574521000448 inner membrane transport permease; Provisional; Region: PRK15066 574521000449 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 574521000450 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 574521000451 active pocket/dimerization site; other site 574521000452 active site 574521000453 phosphorylation site [posttranslational modification] 574521000454 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 574521000455 putative active site [active] 574521000456 putative metal binding site [ion binding]; other site 574521000457 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 574521000458 tetramerization interface [polypeptide binding]; other site 574521000459 active site 574521000460 Uncharacterized conserved protein [Function unknown]; Region: COG5464 574521000461 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 574521000462 pantoate--beta-alanine ligase; Region: panC; TIGR00018 574521000463 Pantoate-beta-alanine ligase; Region: PanC; cd00560 574521000464 active site 574521000465 ATP-binding site [chemical binding]; other site 574521000466 pantoate-binding site; other site 574521000467 HXXH motif; other site 574521000468 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 574521000469 oligomerization interface [polypeptide binding]; other site 574521000470 active site 574521000471 metal binding site [ion binding]; metal-binding site 574521000472 pseudogene, fimbrial protein, truncated by frameshift mutation 574521000473 putative fimbrial protein StaF; Provisional; Region: PRK15262 574521000474 pseudogene, fimbrial protein, truncated by frameshift mutation 574521000475 pseudogene, fimbrial protein, truncated by premature stop codon 574521000476 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 574521000477 PapC N-terminal domain; Region: PapC_N; pfam13954 574521000478 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 574521000479 PapC C-terminal domain; Region: PapC_C; pfam13953 574521000480 pseudogene, periplasmic pilin chaperone, truncated by frameshift mutation 574521000481 Fimbrial protein; Region: Fimbrial; cl01416 574521000482 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 574521000483 catalytic center binding site [active] 574521000484 ATP binding site [chemical binding]; other site 574521000485 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 574521000486 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 574521000487 active site 574521000488 NTP binding site [chemical binding]; other site 574521000489 metal binding triad [ion binding]; metal-binding site 574521000490 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 574521000491 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 574521000492 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 574521000493 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 574521000494 active site 574521000495 nucleotide binding site [chemical binding]; other site 574521000496 HIGH motif; other site 574521000497 KMSKS motif; other site 574521000498 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 574521000499 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 574521000500 2'-5' RNA ligase; Provisional; Region: PRK15124 574521000501 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 574521000502 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 574521000503 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 574521000504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 574521000505 ATP binding site [chemical binding]; other site 574521000506 putative Mg++ binding site [ion binding]; other site 574521000507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521000508 nucleotide binding region [chemical binding]; other site 574521000509 ATP-binding site [chemical binding]; other site 574521000510 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 574521000511 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 574521000512 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 574521000513 Transglycosylase; Region: Transgly; pfam00912 574521000514 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 574521000515 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 574521000516 pseudogene, fimbrial chaperone, truncated by frameshift mutation 574521000517 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 574521000518 PapC N-terminal domain; Region: PapC_N; pfam13954 574521000519 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 574521000520 PapC C-terminal domain; Region: PapC_C; pfam13953 574521000521 Fimbrial protein; Region: Fimbrial; pfam00419 574521000522 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 574521000523 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 574521000524 N-terminal plug; other site 574521000525 ligand-binding site [chemical binding]; other site 574521000526 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 574521000527 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 574521000528 Walker A/P-loop; other site 574521000529 ATP binding site [chemical binding]; other site 574521000530 Q-loop/lid; other site 574521000531 ABC transporter signature motif; other site 574521000532 Walker B; other site 574521000533 D-loop; other site 574521000534 H-loop/switch region; other site 574521000535 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 574521000536 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 574521000537 siderophore binding site; other site 574521000538 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 574521000539 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 574521000540 ABC-ATPase subunit interface; other site 574521000541 dimer interface [polypeptide binding]; other site 574521000542 putative PBP binding regions; other site 574521000543 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 574521000544 ABC-ATPase subunit interface; other site 574521000545 dimer interface [polypeptide binding]; other site 574521000546 putative PBP binding regions; other site 574521000547 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 574521000548 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 574521000549 inhibitor-cofactor binding pocket; inhibition site 574521000550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521000551 catalytic residue [active] 574521000552 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 574521000553 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 574521000554 Cl- selectivity filter; other site 574521000555 Cl- binding residues [ion binding]; other site 574521000556 pore gating glutamate residue; other site 574521000557 dimer interface [polypeptide binding]; other site 574521000558 H+/Cl- coupling transport residue; other site 574521000559 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 574521000560 hypothetical protein; Provisional; Region: PRK10578 574521000561 UPF0126 domain; Region: UPF0126; pfam03458 574521000562 UPF0126 domain; Region: UPF0126; pfam03458 574521000563 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 574521000564 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 574521000565 cobalamin binding residues [chemical binding]; other site 574521000566 putative BtuC binding residues; other site 574521000567 dimer interface [polypeptide binding]; other site 574521000568 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 574521000569 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 574521000570 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 574521000571 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 574521000572 Zn2+ binding site [ion binding]; other site 574521000573 Mg2+ binding site [ion binding]; other site 574521000574 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 574521000575 serine endoprotease; Provisional; Region: PRK10942 574521000576 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 574521000577 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 574521000578 protein binding site [polypeptide binding]; other site 574521000579 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 574521000580 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 574521000581 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 574521000582 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 574521000583 hypothetical protein; Provisional; Region: PRK13677 574521000584 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 574521000585 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 574521000586 trimer interface [polypeptide binding]; other site 574521000587 active site 574521000588 substrate binding site [chemical binding]; other site 574521000589 CoA binding site [chemical binding]; other site 574521000590 PII uridylyl-transferase; Provisional; Region: PRK05007 574521000591 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 574521000592 metal binding triad; other site 574521000593 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 574521000594 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 574521000595 Zn2+ binding site [ion binding]; other site 574521000596 Mg2+ binding site [ion binding]; other site 574521000597 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 574521000598 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 574521000599 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 574521000600 active site 574521000601 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 574521000602 rRNA interaction site [nucleotide binding]; other site 574521000603 S8 interaction site; other site 574521000604 putative laminin-1 binding site; other site 574521000605 elongation factor Ts; Provisional; Region: tsf; PRK09377 574521000606 UBA/TS-N domain; Region: UBA; pfam00627 574521000607 Elongation factor TS; Region: EF_TS; pfam00889 574521000608 Elongation factor TS; Region: EF_TS; pfam00889 574521000609 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 574521000610 putative nucleotide binding site [chemical binding]; other site 574521000611 uridine monophosphate binding site [chemical binding]; other site 574521000612 homohexameric interface [polypeptide binding]; other site 574521000613 ribosome recycling factor; Reviewed; Region: frr; PRK00083 574521000614 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 574521000615 hinge region; other site 574521000616 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 574521000617 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 574521000618 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 574521000619 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 574521000620 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 574521000621 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 574521000622 catalytic residue [active] 574521000623 putative FPP diphosphate binding site; other site 574521000624 putative FPP binding hydrophobic cleft; other site 574521000625 dimer interface [polypeptide binding]; other site 574521000626 putative IPP diphosphate binding site; other site 574521000627 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 574521000628 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 574521000629 zinc metallopeptidase RseP; Provisional; Region: PRK10779 574521000630 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 574521000631 active site 574521000632 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 574521000633 protein binding site [polypeptide binding]; other site 574521000634 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 574521000635 putative substrate binding region [chemical binding]; other site 574521000636 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 574521000637 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 574521000638 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 574521000639 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 574521000640 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 574521000641 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 574521000642 Surface antigen; Region: Bac_surface_Ag; pfam01103 574521000643 periplasmic chaperone; Provisional; Region: PRK10780 574521000644 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 574521000645 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 574521000646 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 574521000647 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 574521000648 trimer interface [polypeptide binding]; other site 574521000649 active site 574521000650 UDP-GlcNAc binding site [chemical binding]; other site 574521000651 lipid binding site [chemical binding]; lipid-binding site 574521000652 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 574521000653 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 574521000654 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 574521000655 active site 574521000656 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 574521000657 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 574521000658 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 574521000659 RNA/DNA hybrid binding site [nucleotide binding]; other site 574521000660 active site 574521000661 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 574521000662 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 574521000663 putative active site [active] 574521000664 putative PHP Thumb interface [polypeptide binding]; other site 574521000665 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 574521000666 generic binding surface II; other site 574521000667 generic binding surface I; other site 574521000668 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 574521000669 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 574521000670 lysine decarboxylase LdcC; Provisional; Region: PRK15399 574521000671 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 574521000672 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 574521000673 homodimer interface [polypeptide binding]; other site 574521000674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521000675 catalytic residue [active] 574521000676 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 574521000677 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 574521000678 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 574521000679 putative metal binding site [ion binding]; other site 574521000680 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 574521000681 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 574521000682 Ligand Binding Site [chemical binding]; other site 574521000683 TilS substrate binding domain; Region: TilS; pfam09179 574521000684 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 574521000685 Rho-binding antiterminator; Provisional; Region: PRK11625 574521000686 hypothetical protein; Provisional; Region: PRK04964 574521000687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 574521000688 hypothetical protein; Provisional; Region: PRK09256 574521000689 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 574521000690 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 574521000691 NlpE N-terminal domain; Region: NlpE; pfam04170 574521000692 hypothetical protein; Provisional; Region: PRK11479 574521000693 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 574521000694 prolyl-tRNA synthetase; Provisional; Region: PRK09194 574521000695 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 574521000696 dimer interface [polypeptide binding]; other site 574521000697 motif 1; other site 574521000698 active site 574521000699 motif 2; other site 574521000700 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 574521000701 putative deacylase active site [active] 574521000702 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 574521000703 active site 574521000704 motif 3; other site 574521000705 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 574521000706 anticodon binding site; other site 574521000707 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 574521000708 homodimer interaction site [polypeptide binding]; other site 574521000709 cofactor binding site; other site 574521000710 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 574521000711 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 574521000712 lipoprotein, YaeC family; Region: TIGR00363 574521000713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521000714 dimer interface [polypeptide binding]; other site 574521000715 conserved gate region; other site 574521000716 ABC-ATPase subunit interface; other site 574521000717 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 574521000718 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 574521000719 Walker A/P-loop; other site 574521000720 ATP binding site [chemical binding]; other site 574521000721 Q-loop/lid; other site 574521000722 ABC transporter signature motif; other site 574521000723 Walker B; other site 574521000724 D-loop; other site 574521000725 H-loop/switch region; other site 574521000726 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 574521000727 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 574521000728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521000729 active site 574521000730 motif I; other site 574521000731 motif II; other site 574521000732 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 574521000733 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 574521000734 active site 574521000735 catalytic tetrad [active] 574521000736 Transcriptional regulator [Transcription]; Region: LysR; COG0583 574521000737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521000738 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 574521000739 putative effector binding pocket; other site 574521000740 dimerization interface [polypeptide binding]; other site 574521000741 hypothetical protein; Provisional; Region: PRK05421 574521000742 putative catalytic site [active] 574521000743 putative metal binding site [ion binding]; other site 574521000744 putative phosphate binding site [ion binding]; other site 574521000745 putative catalytic site [active] 574521000746 putative phosphate binding site [ion binding]; other site 574521000747 putative metal binding site [ion binding]; other site 574521000748 Methyltransferase domain; Region: Methyltransf_23; pfam13489 574521000749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521000750 S-adenosylmethionine binding site [chemical binding]; other site 574521000751 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 574521000752 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 574521000753 N-acetyl-D-glucosamine binding site [chemical binding]; other site 574521000754 catalytic residue [active] 574521000755 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 574521000756 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 574521000757 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 574521000758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521000759 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 574521000760 RNA/DNA hybrid binding site [nucleotide binding]; other site 574521000761 active site 574521000762 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 574521000763 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 574521000764 active site 574521000765 catalytic site [active] 574521000766 substrate binding site [chemical binding]; other site 574521000767 C-N hydrolase family amidase; Provisional; Region: PRK10438 574521000768 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 574521000769 putative active site [active] 574521000770 catalytic triad [active] 574521000771 dimer interface [polypeptide binding]; other site 574521000772 multimer interface [polypeptide binding]; other site 574521000773 C-lysozyme inhibitor; Provisional; Region: PRK09993 574521000774 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 574521000775 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 574521000776 active site 574521000777 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 574521000778 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 574521000779 dimer interface [polypeptide binding]; other site 574521000780 active site 574521000781 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 574521000782 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 574521000783 putative active site [active] 574521000784 putative dimer interface [polypeptide binding]; other site 574521000785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 574521000786 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 574521000787 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 574521000788 NlpC/P60 family; Region: NLPC_P60; pfam00877 574521000789 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 574521000790 HicB family; Region: HicB; pfam05534 574521000791 pseudogene, flagellar system protein FhiA, truncated by premature stop codon 574521000792 hypothetical protein; Validated; Region: PRK06778 574521000793 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 574521000794 ligand binding site [chemical binding]; other site 574521000795 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 574521000796 active site 574521000797 DNA polymerase IV; Validated; Region: PRK02406 574521000798 DNA binding site [nucleotide binding] 574521000799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 574521000800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521000801 Coenzyme A binding pocket [chemical binding]; other site 574521000802 hypothetical protein; Reviewed; Region: PRK09588 574521000803 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 574521000804 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 574521000805 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 574521000806 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 574521000807 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 574521000808 metal binding site [ion binding]; metal-binding site 574521000809 dimer interface [polypeptide binding]; other site 574521000810 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 574521000811 active site 574521000812 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 574521000813 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 574521000814 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 574521000815 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 574521000816 trimer interface [polypeptide binding]; other site 574521000817 eyelet of channel; other site 574521000818 gamma-glutamyl kinase; Provisional; Region: PRK05429 574521000819 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 574521000820 nucleotide binding site [chemical binding]; other site 574521000821 homotetrameric interface [polypeptide binding]; other site 574521000822 putative phosphate binding site [ion binding]; other site 574521000823 putative allosteric binding site; other site 574521000824 PUA domain; Region: PUA; pfam01472 574521000825 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 574521000826 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 574521000827 putative catalytic cysteine [active] 574521000828 integrative element E2348_IE1a 574521000829 E2348_IE1a; pseudogene, C-ter of integrase 574521000830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 574521000831 Transposase; Region: HTH_Tnp_1; pfam01527 574521000832 E2348_IE1a; pseudogene, N-ter part of transposase Orf2 of IS3 family IS element, contains a frameshift mutation 574521000833 Transposase; Region: DEDD_Tnp_IS110; pfam01548 574521000834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 574521000835 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 574521000836 E2348_IE1a; pseudogene, C-ter part of transposase Orf2 of IS3 family IS element 574521000837 integrative element E2348_IE1b 574521000838 E2348_IE1b; pseudogene, integrase, fragment 574521000839 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 574521000840 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 574521000841 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 574521000842 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 574521000843 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 574521000844 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 574521000845 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521000846 DNA binding residues [nucleotide binding] 574521000847 pseudogene, conserved protein, truncated by frameshift mutation 574521000848 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 574521000849 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 574521000850 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 574521000851 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 574521000852 putative active site [active] 574521000853 putative FMN binding site [chemical binding]; other site 574521000854 putative substrate binding site [chemical binding]; other site 574521000855 putative catalytic residue [active] 574521000856 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 574521000857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 574521000858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521000859 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 574521000860 putative effector binding pocket; other site 574521000861 putative dimerization interface [polypeptide binding]; other site 574521000862 Transcriptional regulator [Transcription]; Region: LysR; COG0583 574521000863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521000864 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 574521000865 putative effector binding pocket; other site 574521000866 putative dimerization interface [polypeptide binding]; other site 574521000867 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 574521000868 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 574521000869 active site 574521000870 catalytic tetrad [active] 574521000871 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 574521000872 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 574521000873 active site 574521000874 catalytic tetrad [active] 574521000875 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 574521000876 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 574521000877 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 574521000878 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 574521000879 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 574521000880 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 574521000881 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521000882 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 574521000883 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 574521000884 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 574521000885 active site 574521000886 catalytic tetrad [active] 574521000887 Predicted membrane protein [Function unknown]; Region: COG3059 574521000888 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 574521000889 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 574521000890 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 574521000891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521000892 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 574521000893 Cupin; Region: Cupin_6; pfam12852 574521000894 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 574521000895 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521000896 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 574521000897 Cysteine-rich domain; Region: CCG; pfam02754 574521000898 Cysteine-rich domain; Region: CCG; pfam02754 574521000899 iron-sulfur cluster-binding protein; Region: TIGR00273 574521000900 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 574521000901 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 574521000902 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 574521000903 Uncharacterized conserved protein [Function unknown]; Region: COG1556 574521000904 pseudogene, inner membrane protein, truncated by deletion 574521000905 choline dehydrogenase; Validated; Region: PRK02106 574521000906 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 574521000907 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 574521000908 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 574521000909 tetrameric interface [polypeptide binding]; other site 574521000910 NAD binding site [chemical binding]; other site 574521000911 catalytic residues [active] 574521000912 transcriptional regulator BetI; Validated; Region: PRK00767 574521000913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521000914 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 574521000915 choline transport protein BetT; Provisional; Region: PRK09928 574521000916 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521000917 DNA binding residues [nucleotide binding] 574521000918 dimerization interface [polypeptide binding]; other site 574521000919 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521000920 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 574521000921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521000922 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 574521000923 dimerization interface [polypeptide binding]; other site 574521000924 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 574521000925 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 574521000926 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 574521000927 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 574521000928 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 574521000929 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 574521000930 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 574521000931 CoA binding domain; Region: CoA_binding; pfam02629 574521000932 CoA-ligase; Region: Ligase_CoA; pfam00549 574521000933 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 574521000934 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 574521000935 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 574521000936 putative substrate binding site [chemical binding]; other site 574521000937 nucleotide binding site [chemical binding]; other site 574521000938 nucleotide binding site [chemical binding]; other site 574521000939 homodimer interface [polypeptide binding]; other site 574521000940 putative deaminase; Validated; Region: PRK06846 574521000941 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 574521000942 active site 574521000943 pseudogene, oxidoreductase, Zn-dependent and NAD(P)-binding, truncated by frameshift mutation 574521000944 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 574521000945 hypothetical protein; Provisional; Region: PRK09929 574521000946 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 574521000947 Propionate catabolism activator; Region: PrpR_N; pfam06506 574521000948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521000949 Walker A motif; other site 574521000950 ATP binding site [chemical binding]; other site 574521000951 Walker B motif; other site 574521000952 arginine finger; other site 574521000953 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 574521000954 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 574521000955 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 574521000956 tetramer interface [polypeptide binding]; other site 574521000957 active site 574521000958 Mg2+/Mn2+ binding site [ion binding]; other site 574521000959 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 574521000960 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 574521000961 dimer interface [polypeptide binding]; other site 574521000962 active site 574521000963 citrylCoA binding site [chemical binding]; other site 574521000964 oxalacetate/citrate binding site [chemical binding]; other site 574521000965 coenzyme A binding site [chemical binding]; other site 574521000966 catalytic triad [active] 574521000967 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 574521000968 2-methylcitrate dehydratase; Region: prpD; TIGR02330 574521000969 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 574521000970 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 574521000971 acyl-activating enzyme (AAE) consensus motif; other site 574521000972 AMP binding site [chemical binding]; other site 574521000973 active site 574521000974 CoA binding site [chemical binding]; other site 574521000975 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 574521000976 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 574521000977 Na binding site [ion binding]; other site 574521000978 putative substrate binding site [chemical binding]; other site 574521000979 cytosine deaminase; Provisional; Region: PRK09230 574521000980 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 574521000981 active site 574521000982 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 574521000983 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 574521000984 active site 574521000985 substrate binding site [chemical binding]; other site 574521000986 trimer interface [polypeptide binding]; other site 574521000987 CoA binding site [chemical binding]; other site 574521000988 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 574521000989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521000990 putative substrate translocation pore; other site 574521000991 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 574521000992 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 574521000993 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 574521000994 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 574521000995 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 574521000996 lac repressor; Reviewed; Region: lacI; PRK09526 574521000997 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521000998 DNA binding site [nucleotide binding] 574521000999 domain linker motif; other site 574521001000 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 574521001001 ligand binding site [chemical binding]; other site 574521001002 dimerization interface (open form) [polypeptide binding]; other site 574521001003 dimerization interface (closed form) [polypeptide binding]; other site 574521001004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 574521001005 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 574521001006 S-formylglutathione hydrolase; Region: PLN02442 574521001007 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 574521001008 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 574521001009 substrate binding site [chemical binding]; other site 574521001010 catalytic Zn binding site [ion binding]; other site 574521001011 NAD binding site [chemical binding]; other site 574521001012 structural Zn binding site [ion binding]; other site 574521001013 dimer interface [polypeptide binding]; other site 574521001014 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 574521001015 putative metal binding site [ion binding]; other site 574521001016 putative homodimer interface [polypeptide binding]; other site 574521001017 putative homotetramer interface [polypeptide binding]; other site 574521001018 putative homodimer-homodimer interface [polypeptide binding]; other site 574521001019 putative allosteric switch controlling residues; other site 574521001020 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 574521001021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521001022 substrate binding pocket [chemical binding]; other site 574521001023 membrane-bound complex binding site; other site 574521001024 hinge residues; other site 574521001025 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 574521001026 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 574521001027 Walker A/P-loop; other site 574521001028 ATP binding site [chemical binding]; other site 574521001029 Q-loop/lid; other site 574521001030 ABC transporter signature motif; other site 574521001031 Walker B; other site 574521001032 D-loop; other site 574521001033 H-loop/switch region; other site 574521001034 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 574521001035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521001036 dimer interface [polypeptide binding]; other site 574521001037 conserved gate region; other site 574521001038 putative PBP binding loops; other site 574521001039 ABC-ATPase subunit interface; other site 574521001040 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 574521001041 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 574521001042 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 574521001043 dimer interface [polypeptide binding]; other site 574521001044 active site 574521001045 Schiff base residues; other site 574521001046 pseudogene, flagellin structural protein, truncated by multiple mutations 574521001047 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 574521001048 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 574521001049 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 574521001050 microcin B17 transporter; Reviewed; Region: PRK11098 574521001051 pseudogene, DNA-binding transcriptional regulator, truncated by frameshift mutation 574521001052 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 574521001053 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 574521001054 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 574521001055 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 574521001056 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 574521001057 anti-RssB factor; Provisional; Region: PRK10244 574521001058 alkaline phosphatase; Provisional; Region: PRK10518 574521001059 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 574521001060 dimer interface [polypeptide binding]; other site 574521001061 active site 574521001062 hypothetical protein; Provisional; Region: PRK11505 574521001063 psiF repeat; Region: PsiF_repeat; pfam07769 574521001064 psiF repeat; Region: PsiF_repeat; pfam07769 574521001065 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 574521001066 MASE2 domain; Region: MASE2; pfam05230 574521001067 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 574521001068 metal binding site [ion binding]; metal-binding site 574521001069 active site 574521001070 I-site; other site 574521001071 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 574521001072 pyrroline-5-carboxylate reductase; Region: PLN02688 574521001073 hypothetical protein; Validated; Region: PRK00124 574521001074 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 574521001075 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 574521001076 ADP binding site [chemical binding]; other site 574521001077 magnesium binding site [ion binding]; other site 574521001078 putative shikimate binding site; other site 574521001079 hypothetical protein; Provisional; Region: PRK10380 574521001080 hypothetical protein; Provisional; Region: PRK10481 574521001081 hypothetical protein; Provisional; Region: PRK10579 574521001082 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 574521001083 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 574521001084 fructokinase; Reviewed; Region: PRK09557 574521001085 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 574521001086 nucleotide binding site [chemical binding]; other site 574521001087 MFS transport protein AraJ; Provisional; Region: PRK10091 574521001088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521001089 putative substrate translocation pore; other site 574521001090 exonuclease subunit SbcC; Provisional; Region: PRK10246 574521001091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521001092 Walker A/P-loop; other site 574521001093 ATP binding site [chemical binding]; other site 574521001094 Q-loop/lid; other site 574521001095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521001096 ABC transporter signature motif; other site 574521001097 Walker B; other site 574521001098 D-loop; other site 574521001099 H-loop/switch region; other site 574521001100 exonuclease subunit SbcD; Provisional; Region: PRK10966 574521001101 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 574521001102 active site 574521001103 metal binding site [ion binding]; metal-binding site 574521001104 DNA binding site [nucleotide binding] 574521001105 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 574521001106 transcriptional regulator PhoB; Provisional; Region: PRK10161 574521001107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521001108 active site 574521001109 phosphorylation site [posttranslational modification] 574521001110 intermolecular recognition site; other site 574521001111 dimerization interface [polypeptide binding]; other site 574521001112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521001113 DNA binding site [nucleotide binding] 574521001114 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 574521001115 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 574521001116 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 574521001117 putative active site [active] 574521001118 heme pocket [chemical binding]; other site 574521001119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521001120 dimer interface [polypeptide binding]; other site 574521001121 phosphorylation site [posttranslational modification] 574521001122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521001123 ATP binding site [chemical binding]; other site 574521001124 Mg2+ binding site [ion binding]; other site 574521001125 G-X-G motif; other site 574521001126 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 574521001127 putative proline-specific permease; Provisional; Region: proY; PRK10580 574521001128 Spore germination protein; Region: Spore_permease; cl17796 574521001129 maltodextrin glucosidase; Provisional; Region: PRK10785 574521001130 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 574521001131 homodimer interface [polypeptide binding]; other site 574521001132 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 574521001133 active site 574521001134 homodimer interface [polypeptide binding]; other site 574521001135 catalytic site [active] 574521001136 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 574521001137 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 574521001138 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 574521001139 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 574521001140 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 574521001141 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 574521001142 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 574521001143 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 574521001144 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 574521001145 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 574521001146 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 574521001147 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 574521001148 Protein export membrane protein; Region: SecD_SecF; pfam02355 574521001149 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 574521001150 active site 574521001151 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 574521001152 hypothetical protein; Provisional; Region: PRK11530 574521001153 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 574521001154 ATP cone domain; Region: ATP-cone; pfam03477 574521001155 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 574521001156 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 574521001157 catalytic motif [active] 574521001158 Zn binding site [ion binding]; other site 574521001159 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 574521001160 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 574521001161 homopentamer interface [polypeptide binding]; other site 574521001162 active site 574521001163 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 574521001164 putative RNA binding site [nucleotide binding]; other site 574521001165 thiamine monophosphate kinase; Provisional; Region: PRK05731 574521001166 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 574521001167 ATP binding site [chemical binding]; other site 574521001168 dimerization interface [polypeptide binding]; other site 574521001169 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 574521001170 tetramer interfaces [polypeptide binding]; other site 574521001171 binuclear metal-binding site [ion binding]; other site 574521001172 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 574521001173 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 574521001174 active site 574521001175 catalytic tetrad [active] 574521001176 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 574521001177 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 574521001178 TPP-binding site; other site 574521001179 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 574521001180 PYR/PP interface [polypeptide binding]; other site 574521001181 dimer interface [polypeptide binding]; other site 574521001182 TPP binding site [chemical binding]; other site 574521001183 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 574521001184 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 574521001185 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 574521001186 substrate binding pocket [chemical binding]; other site 574521001187 chain length determination region; other site 574521001188 substrate-Mg2+ binding site; other site 574521001189 catalytic residues [active] 574521001190 aspartate-rich region 1; other site 574521001191 active site lid residues [active] 574521001192 aspartate-rich region 2; other site 574521001193 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 574521001194 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 574521001195 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 574521001196 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 574521001197 Ligand Binding Site [chemical binding]; other site 574521001198 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 574521001199 active site residue [active] 574521001200 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 574521001201 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 574521001202 conserved cys residue [active] 574521001203 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 574521001204 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 574521001205 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 574521001206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 574521001207 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 574521001208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521001209 Major Facilitator Superfamily; Region: MFS_1; pfam07690 574521001210 putative substrate translocation pore; other site 574521001211 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 574521001212 UbiA prenyltransferase family; Region: UbiA; pfam01040 574521001213 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 574521001214 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 574521001215 Subunit I/III interface [polypeptide binding]; other site 574521001216 Subunit III/IV interface [polypeptide binding]; other site 574521001217 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 574521001218 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 574521001219 D-pathway; other site 574521001220 Putative ubiquinol binding site [chemical binding]; other site 574521001221 Low-spin heme (heme b) binding site [chemical binding]; other site 574521001222 Putative water exit pathway; other site 574521001223 Binuclear center (heme o3/CuB) [ion binding]; other site 574521001224 K-pathway; other site 574521001225 Putative proton exit pathway; other site 574521001226 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 574521001227 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 574521001228 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 574521001229 muropeptide transporter; Reviewed; Region: ampG; PRK11902 574521001230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521001231 putative substrate translocation pore; other site 574521001232 hypothetical protein; Provisional; Region: PRK11627 574521001233 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 574521001234 transcriptional regulator BolA; Provisional; Region: PRK11628 574521001235 trigger factor; Provisional; Region: tig; PRK01490 574521001236 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 574521001237 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 574521001238 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 574521001239 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 574521001240 oligomer interface [polypeptide binding]; other site 574521001241 active site residues [active] 574521001242 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 574521001243 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 574521001244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521001245 Walker A motif; other site 574521001246 ATP binding site [chemical binding]; other site 574521001247 Walker B motif; other site 574521001248 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 574521001249 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 574521001250 Found in ATP-dependent protease La (LON); Region: LON; smart00464 574521001251 Found in ATP-dependent protease La (LON); Region: LON; smart00464 574521001252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521001253 Walker A motif; other site 574521001254 ATP binding site [chemical binding]; other site 574521001255 Walker B motif; other site 574521001256 arginine finger; other site 574521001257 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 574521001258 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 574521001259 IHF dimer interface [polypeptide binding]; other site 574521001260 IHF - DNA interface [nucleotide binding]; other site 574521001261 periplasmic folding chaperone; Provisional; Region: PRK10788 574521001262 SurA N-terminal domain; Region: SurA_N_3; cl07813 574521001263 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 574521001264 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 574521001265 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 574521001266 active site 574521001267 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 574521001268 Ligand Binding Site [chemical binding]; other site 574521001269 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 574521001270 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 574521001271 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 574521001272 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 574521001273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521001274 active site 574521001275 motif I; other site 574521001276 motif II; other site 574521001277 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 574521001278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 574521001279 putative DNA binding site [nucleotide binding]; other site 574521001280 putative Zn2+ binding site [ion binding]; other site 574521001281 AsnC family; Region: AsnC_trans_reg; pfam01037 574521001282 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 574521001283 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 574521001284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521001285 Walker A/P-loop; other site 574521001286 ATP binding site [chemical binding]; other site 574521001287 Q-loop/lid; other site 574521001288 ABC transporter signature motif; other site 574521001289 Walker B; other site 574521001290 D-loop; other site 574521001291 H-loop/switch region; other site 574521001292 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 574521001293 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 574521001294 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 574521001295 Walker A/P-loop; other site 574521001296 ATP binding site [chemical binding]; other site 574521001297 Q-loop/lid; other site 574521001298 ABC transporter signature motif; other site 574521001299 Walker B; other site 574521001300 D-loop; other site 574521001301 H-loop/switch region; other site 574521001302 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 574521001303 Nitrogen regulatory protein P-II; Region: P-II; smart00938 574521001304 ammonium transporter; Provisional; Region: PRK10666 574521001305 acyl-CoA thioesterase II; Provisional; Region: PRK10526 574521001306 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 574521001307 active site 574521001308 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 574521001309 catalytic triad [active] 574521001310 dimer interface [polypeptide binding]; other site 574521001311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 574521001312 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521001313 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 574521001314 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 574521001315 DNA binding site [nucleotide binding] 574521001316 active site 574521001317 Uncharacterized conserved protein [Function unknown]; Region: COG5507 574521001318 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 574521001319 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 574521001320 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521001321 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 574521001322 pseudogene, maltose O-acetyltransferase, truncated by frameshift mutation 574521001323 gene expression modulator; Provisional; Region: PRK10945 574521001324 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 574521001325 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 574521001326 Protein export membrane protein; Region: SecD_SecF; cl14618 574521001327 Protein export membrane protein; Region: SecD_SecF; cl14618 574521001328 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 574521001329 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521001330 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521001331 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 574521001332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521001333 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 574521001334 hypothetical protein; Provisional; Region: PRK11281 574521001335 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 574521001336 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 574521001337 Mechanosensitive ion channel; Region: MS_channel; pfam00924 574521001338 hypothetical protein; Provisional; Region: PRK11038 574521001339 primosomal replication protein N''; Provisional; Region: PRK10093 574521001340 hypothetical protein; Provisional; Region: PRK10527 574521001341 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 574521001342 active site 574521001343 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 574521001344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521001345 Walker A motif; other site 574521001346 ATP binding site [chemical binding]; other site 574521001347 Walker B motif; other site 574521001348 DNA polymerase III subunit delta'; Validated; Region: PRK08485 574521001349 arginine finger; other site 574521001350 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 574521001351 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 574521001352 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 574521001353 hypothetical protein; Validated; Region: PRK00153 574521001354 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 574521001355 RecR protein; Region: RecR; pfam02132 574521001356 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 574521001357 putative active site [active] 574521001358 putative metal-binding site [ion binding]; other site 574521001359 tetramer interface [polypeptide binding]; other site 574521001360 heat shock protein 90; Provisional; Region: PRK05218 574521001361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521001362 ATP binding site [chemical binding]; other site 574521001363 Mg2+ binding site [ion binding]; other site 574521001364 G-X-G motif; other site 574521001365 adenylate kinase; Reviewed; Region: adk; PRK00279 574521001366 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 574521001367 AMP-binding site [chemical binding]; other site 574521001368 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 574521001369 ferrochelatase; Region: hemH; TIGR00109 574521001370 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 574521001371 C-terminal domain interface [polypeptide binding]; other site 574521001372 active site 574521001373 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 574521001374 active site 574521001375 N-terminal domain interface [polypeptide binding]; other site 574521001376 acetyl esterase; Provisional; Region: PRK10162 574521001377 inosine/guanosine kinase; Provisional; Region: PRK15074 574521001378 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 574521001379 putative cation:proton antiport protein; Provisional; Region: PRK10669 574521001380 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 574521001381 TrkA-N domain; Region: TrkA_N; pfam02254 574521001382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521001383 Major Facilitator Superfamily; Region: MFS_1; pfam07690 574521001384 putative substrate translocation pore; other site 574521001385 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 574521001386 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 574521001387 active site 574521001388 metal binding site [ion binding]; metal-binding site 574521001389 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 574521001390 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 574521001391 putative deacylase active site [active] 574521001392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 574521001393 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 574521001394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521001395 non-specific DNA binding site [nucleotide binding]; other site 574521001396 salt bridge; other site 574521001397 sequence-specific DNA binding site [nucleotide binding]; other site 574521001398 copper exporting ATPase; Provisional; Region: copA; PRK10671 574521001399 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 574521001400 metal-binding site [ion binding] 574521001401 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 574521001402 metal-binding site [ion binding] 574521001403 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 574521001404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521001405 motif II; other site 574521001406 glutaminase; Reviewed; Region: PRK12356 574521001407 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 574521001408 amino acid transporter; Region: 2A0306; TIGR00909 574521001409 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 574521001410 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 574521001411 DNA binding residues [nucleotide binding] 574521001412 dimer interface [polypeptide binding]; other site 574521001413 copper binding site [ion binding]; other site 574521001414 pseudogene, conserved protein, truncated by multiple mutations 574521001415 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 574521001416 YadA-like C-terminal region; Region: YadA; pfam03895 574521001417 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 574521001418 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 574521001419 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 574521001420 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 574521001421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521001422 Walker A/P-loop; other site 574521001423 ATP binding site [chemical binding]; other site 574521001424 Q-loop/lid; other site 574521001425 ABC transporter signature motif; other site 574521001426 Walker B; other site 574521001427 D-loop; other site 574521001428 H-loop/switch region; other site 574521001429 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 574521001430 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 574521001431 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 574521001432 oxidoreductase; Provisional; Region: PRK08017 574521001433 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 574521001434 NADP binding site [chemical binding]; other site 574521001435 active site 574521001436 steroid binding site; other site 574521001437 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 574521001438 active site 574521001439 catalytic triad [active] 574521001440 oxyanion hole [active] 574521001441 switch loop; other site 574521001442 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 574521001443 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 574521001444 Walker A/P-loop; other site 574521001445 ATP binding site [chemical binding]; other site 574521001446 Q-loop/lid; other site 574521001447 ABC transporter signature motif; other site 574521001448 Walker B; other site 574521001449 D-loop; other site 574521001450 H-loop/switch region; other site 574521001451 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 574521001452 FtsX-like permease family; Region: FtsX; pfam02687 574521001453 FtsX-like permease family; Region: FtsX; pfam02687 574521001454 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521001455 Homeodomain-like domain; Region: HTH_32; pfam13565 574521001456 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 574521001457 Integrase core domain; Region: rve; pfam00665 574521001458 Integrase core domain; Region: rve_3; pfam13683 574521001459 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 574521001460 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 574521001461 active site residue [active] 574521001462 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 574521001463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521001464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 574521001465 dimerization interface [polypeptide binding]; other site 574521001466 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 574521001467 ureidoglycolate hydrolase; Provisional; Region: PRK03606 574521001468 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 574521001469 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 574521001470 Bacterial transcriptional regulator; Region: IclR; pfam01614 574521001471 glyoxylate carboligase; Provisional; Region: PRK11269 574521001472 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 574521001473 PYR/PP interface [polypeptide binding]; other site 574521001474 dimer interface [polypeptide binding]; other site 574521001475 TPP binding site [chemical binding]; other site 574521001476 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 574521001477 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 574521001478 TPP-binding site [chemical binding]; other site 574521001479 hydroxypyruvate isomerase; Provisional; Region: PRK09997 574521001480 tartronate semialdehyde reductase; Provisional; Region: PRK15059 574521001481 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 574521001482 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 574521001483 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 574521001484 Na binding site [ion binding]; other site 574521001485 substrate binding site [chemical binding]; other site 574521001486 allantoinase; Provisional; Region: PRK08044 574521001487 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 574521001488 active site 574521001489 putative uracil/xanthine transporter; Provisional; Region: PRK11412 574521001490 glycerate kinase II; Provisional; Region: PRK09932 574521001491 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 574521001492 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 574521001493 Cupin domain; Region: Cupin_2; cl17218 574521001494 allantoate amidohydrolase; Region: AllC; TIGR03176 574521001495 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 574521001496 active site 574521001497 metal binding site [ion binding]; metal-binding site 574521001498 dimer interface [polypeptide binding]; other site 574521001499 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 574521001500 membrane protein FdrA; Validated; Region: PRK06091 574521001501 CoA binding domain; Region: CoA_binding; pfam02629 574521001502 CoA-ligase; Region: Ligase_CoA; pfam00549 574521001503 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 574521001504 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 574521001505 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 574521001506 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 574521001507 putative substrate binding site [chemical binding]; other site 574521001508 nucleotide binding site [chemical binding]; other site 574521001509 nucleotide binding site [chemical binding]; other site 574521001510 homodimer interface [polypeptide binding]; other site 574521001511 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 574521001512 ATP-grasp domain; Region: ATP-grasp; pfam02222 574521001513 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 574521001514 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 574521001515 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 574521001516 putative active site [active] 574521001517 putative metal binding site [ion binding]; other site 574521001518 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 574521001519 substrate binding site [chemical binding]; other site 574521001520 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 574521001521 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 574521001522 active site 574521001523 HIGH motif; other site 574521001524 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 574521001525 KMSKS motif; other site 574521001526 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 574521001527 tRNA binding surface [nucleotide binding]; other site 574521001528 anticodon binding site; other site 574521001529 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 574521001530 ribosome-associated protein; Provisional; Region: PRK11507 574521001531 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 574521001532 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 574521001533 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 574521001534 homodimer interface [polypeptide binding]; other site 574521001535 NADP binding site [chemical binding]; other site 574521001536 substrate binding site [chemical binding]; other site 574521001537 prophage E2348_PP1 574521001538 E2348_PP1; pseudogene, C-ter part of integrase, truncated by frameshift mutation 574521001539 E2348_PP1; pseudogene, part of tail fiber assembly protein 574521001540 Methyltransferase domain; Region: Methyltransf_12; pfam08242 574521001541 S-adenosylmethionine binding site [chemical binding]; other site 574521001542 outer membrane protease; Reviewed; Region: PRK10993 574521001543 hypothetical protein; Provisional; Region: PRK09936 574521001544 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 574521001545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 574521001546 TPR motif; other site 574521001547 binding surface 574521001548 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 574521001549 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 574521001550 active site 574521001551 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 574521001552 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 574521001553 sensor kinase CusS; Provisional; Region: PRK09835 574521001554 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 574521001555 dimerization interface [polypeptide binding]; other site 574521001556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521001557 dimer interface [polypeptide binding]; other site 574521001558 phosphorylation site [posttranslational modification] 574521001559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521001560 ATP binding site [chemical binding]; other site 574521001561 Mg2+ binding site [ion binding]; other site 574521001562 G-X-G motif; other site 574521001563 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 574521001564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521001565 active site 574521001566 phosphorylation site [posttranslational modification] 574521001567 intermolecular recognition site; other site 574521001568 dimerization interface [polypeptide binding]; other site 574521001569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521001570 DNA binding site [nucleotide binding] 574521001571 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 574521001572 periplasmic copper-binding protein; Provisional; Region: PRK09838 574521001573 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 574521001574 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521001575 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 574521001576 phenylalanine transporter; Provisional; Region: PRK10249 574521001577 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 574521001578 Mechanosensitive ion channel; Region: MS_channel; pfam00924 574521001579 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 574521001580 dimer interface [polypeptide binding]; other site 574521001581 FMN binding site [chemical binding]; other site 574521001582 hypothetical protein; Provisional; Region: PRK10250 574521001583 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 574521001584 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 574521001585 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 574521001586 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 574521001587 Hok/gef family; Region: HOK_GEF; pfam01848 574521001588 Hok/gef family; Region: HOK_GEF; pfam01848 574521001589 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 574521001590 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 574521001591 outer membrane receptor FepA; Provisional; Region: PRK13524 574521001592 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 574521001593 N-terminal plug; other site 574521001594 ligand-binding site [chemical binding]; other site 574521001595 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 574521001596 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 574521001597 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 574521001598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 574521001599 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 574521001600 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 574521001601 acyl-activating enzyme (AAE) consensus motif; other site 574521001602 AMP binding site [chemical binding]; other site 574521001603 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 574521001604 pseudogene, regulator of length of O-antigen component of lipopolysaccharide chains, truncated by premature stop codon 574521001605 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 574521001606 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 574521001607 Walker A/P-loop; other site 574521001608 ATP binding site [chemical binding]; other site 574521001609 Q-loop/lid; other site 574521001610 ABC transporter signature motif; other site 574521001611 Walker B; other site 574521001612 D-loop; other site 574521001613 H-loop/switch region; other site 574521001614 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 574521001615 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 574521001616 ABC-ATPase subunit interface; other site 574521001617 dimer interface [polypeptide binding]; other site 574521001618 putative PBP binding regions; other site 574521001619 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 574521001620 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 574521001621 ABC-ATPase subunit interface; other site 574521001622 dimer interface [polypeptide binding]; other site 574521001623 putative PBP binding regions; other site 574521001624 enterobactin exporter EntS; Provisional; Region: PRK10489 574521001625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521001626 putative substrate translocation pore; other site 574521001627 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 574521001628 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 574521001629 siderophore binding site; other site 574521001630 isochorismate synthase EntC; Provisional; Region: PRK15016 574521001631 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 574521001632 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 574521001633 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 574521001634 acyl-activating enzyme (AAE) consensus motif; other site 574521001635 active site 574521001636 AMP binding site [chemical binding]; other site 574521001637 substrate binding site [chemical binding]; other site 574521001638 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 574521001639 hydrophobic substrate binding pocket; other site 574521001640 Isochorismatase family; Region: Isochorismatase; pfam00857 574521001641 active site 574521001642 conserved cis-peptide bond; other site 574521001643 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 574521001644 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 574521001645 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 574521001646 putative NAD(P) binding site [chemical binding]; other site 574521001647 active site 574521001648 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 574521001649 CoenzymeA binding site [chemical binding]; other site 574521001650 subunit interaction site [polypeptide binding]; other site 574521001651 PHB binding site; other site 574521001652 carbon starvation protein A; Provisional; Region: PRK15015 574521001653 Carbon starvation protein CstA; Region: CstA; pfam02554 574521001654 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 574521001655 Uncharacterized small protein [Function unknown]; Region: COG2879 574521001656 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 574521001657 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 574521001658 putative active site [active] 574521001659 metal binding site [ion binding]; metal-binding site 574521001660 methionine aminotransferase; Validated; Region: PRK09082 574521001661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 574521001662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521001663 homodimer interface [polypeptide binding]; other site 574521001664 catalytic residue [active] 574521001665 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 574521001666 ParB-like nuclease domain; Region: ParBc; pfam02195 574521001667 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 574521001668 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 574521001669 Active Sites [active] 574521001670 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 574521001671 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 574521001672 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521001673 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 574521001674 dimerization interface [polypeptide binding]; other site 574521001675 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 574521001676 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 574521001677 dimerization domain [polypeptide binding]; other site 574521001678 dimer interface [polypeptide binding]; other site 574521001679 catalytic residues [active] 574521001680 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 574521001681 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 574521001682 dimer interface [polypeptide binding]; other site 574521001683 decamer (pentamer of dimers) interface [polypeptide binding]; other site 574521001684 catalytic triad [active] 574521001685 peroxidatic and resolving cysteines [active] 574521001686 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 574521001687 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 574521001688 catalytic residue [active] 574521001689 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 574521001690 catalytic residues [active] 574521001691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 574521001692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521001693 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 574521001694 Ligand Binding Site [chemical binding]; other site 574521001695 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 574521001696 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 574521001697 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 574521001698 B1 nucleotide binding pocket [chemical binding]; other site 574521001699 B2 nucleotide binding pocket [chemical binding]; other site 574521001700 CAS motifs; other site 574521001701 active site 574521001702 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 574521001703 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 574521001704 transmembrane helices; other site 574521001705 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 574521001706 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 574521001707 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 574521001708 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 574521001709 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 574521001710 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 574521001711 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 574521001712 putative active site [active] 574521001713 (T/H)XGH motif; other site 574521001714 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 574521001715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 574521001716 putative active site [active] 574521001717 heme pocket [chemical binding]; other site 574521001718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521001719 ATP binding site [chemical binding]; other site 574521001720 Mg2+ binding site [ion binding]; other site 574521001721 G-X-G motif; other site 574521001722 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 574521001723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521001724 active site 574521001725 phosphorylation site [posttranslational modification] 574521001726 intermolecular recognition site; other site 574521001727 dimerization interface [polypeptide binding]; other site 574521001728 Transcriptional regulator; Region: CitT; pfam12431 574521001729 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 574521001730 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 574521001731 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 574521001732 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 574521001733 DNA-binding site [nucleotide binding]; DNA binding site 574521001734 RNA-binding motif; other site 574521001735 chromosome condensation membrane protein; Provisional; Region: PRK14196 574521001736 Predicted amidohydrolase [General function prediction only]; Region: COG0388 574521001737 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 574521001738 putative active site [active] 574521001739 catalytic triad [active] 574521001740 putative dimer interface [polypeptide binding]; other site 574521001741 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 574521001742 lipoyl synthase; Provisional; Region: PRK05481 574521001743 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521001744 FeS/SAM binding site; other site 574521001745 pseudogene, N-ter part of DNA-binding transcriptional regulator 574521001746 lipoate-protein ligase B; Provisional; Region: PRK14342 574521001747 hypothetical protein; Provisional; Region: PRK04998 574521001748 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 574521001749 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 574521001750 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 574521001751 rare lipoprotein A; Provisional; Region: PRK10672 574521001752 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 574521001753 Sporulation related domain; Region: SPOR; pfam05036 574521001754 cell wall shape-determining protein; Provisional; Region: PRK10794 574521001755 penicillin-binding protein 2; Provisional; Region: PRK10795 574521001756 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 574521001757 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 574521001758 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 574521001759 ribosome-associated protein; Provisional; Region: PRK11538 574521001760 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 574521001761 catalytic core [active] 574521001762 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 574521001763 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 574521001764 active site 574521001765 (T/H)XGH motif; other site 574521001766 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 574521001767 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 574521001768 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 574521001769 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 574521001770 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 574521001771 HIGH motif; other site 574521001772 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 574521001773 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 574521001774 active site 574521001775 KMSKS motif; other site 574521001776 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 574521001777 tRNA binding surface [nucleotide binding]; other site 574521001778 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 574521001779 hypothetical protein; Provisional; Region: PRK11032 574521001780 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 574521001781 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 574521001782 active site 574521001783 tetramer interface [polypeptide binding]; other site 574521001784 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 574521001785 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 574521001786 Walker A/P-loop; other site 574521001787 ATP binding site [chemical binding]; other site 574521001788 Q-loop/lid; other site 574521001789 ABC transporter signature motif; other site 574521001790 Walker B; other site 574521001791 D-loop; other site 574521001792 H-loop/switch region; other site 574521001793 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 574521001794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521001795 dimer interface [polypeptide binding]; other site 574521001796 conserved gate region; other site 574521001797 putative PBP binding loops; other site 574521001798 ABC-ATPase subunit interface; other site 574521001799 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 574521001800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521001801 dimer interface [polypeptide binding]; other site 574521001802 conserved gate region; other site 574521001803 putative PBP binding loops; other site 574521001804 ABC-ATPase subunit interface; other site 574521001805 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 574521001806 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521001807 substrate binding pocket [chemical binding]; other site 574521001808 membrane-bound complex binding site; other site 574521001809 hinge residues; other site 574521001810 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 574521001811 Uncharacterized conserved protein [Function unknown]; Region: COG3391 574521001812 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 574521001813 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 574521001814 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 574521001815 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 574521001816 putative active site [active] 574521001817 catalytic triad [active] 574521001818 putative dimer interface [polypeptide binding]; other site 574521001819 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 574521001820 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 574521001821 Transporter associated domain; Region: CorC_HlyC; smart01091 574521001822 metal-binding heat shock protein; Provisional; Region: PRK00016 574521001823 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 574521001824 PhoH-like protein; Region: PhoH; pfam02562 574521001825 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 574521001826 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 574521001827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521001828 FeS/SAM binding site; other site 574521001829 TRAM domain; Region: TRAM; pfam01938 574521001830 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 574521001831 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 574521001832 asparagine synthetase B; Provisional; Region: asnB; PRK09431 574521001833 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 574521001834 active site 574521001835 dimer interface [polypeptide binding]; other site 574521001836 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 574521001837 Ligand Binding Site [chemical binding]; other site 574521001838 Molecular Tunnel; other site 574521001839 UMP phosphatase; Provisional; Region: PRK10444 574521001840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521001841 active site 574521001842 motif I; other site 574521001843 motif II; other site 574521001844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521001845 MarR family; Region: MarR; pfam01047 574521001846 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 574521001847 ROK family; Region: ROK; pfam00480 574521001848 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 574521001849 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 574521001850 active site 574521001851 dimer interface [polypeptide binding]; other site 574521001852 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 574521001853 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 574521001854 active site 574521001855 trimer interface [polypeptide binding]; other site 574521001856 allosteric site; other site 574521001857 active site lid [active] 574521001858 hexamer (dimer of trimers) interface [polypeptide binding]; other site 574521001859 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 574521001860 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 574521001861 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 574521001862 active site turn [active] 574521001863 phosphorylation site [posttranslational modification] 574521001864 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 574521001865 HPr interaction site; other site 574521001866 glycerol kinase (GK) interaction site [polypeptide binding]; other site 574521001867 active site 574521001868 phosphorylation site [posttranslational modification] 574521001869 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 574521001870 transmembrane helices; other site 574521001871 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 574521001872 Domain of unknown function (DUF386); Region: DUF386; cl01047 574521001873 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 574521001874 BNR repeat-like domain; Region: BNR_2; pfam13088 574521001875 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 574521001876 dihydrodipicolinate synthase; Region: dapA; TIGR00674 574521001877 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 574521001878 inhibitor site; inhibition site 574521001879 active site 574521001880 dimer interface [polypeptide binding]; other site 574521001881 catalytic residue [active] 574521001882 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 574521001883 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 574521001884 putative active site [active] 574521001885 metal binding site [ion binding]; metal-binding site 574521001886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 574521001887 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 574521001888 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 574521001889 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 574521001890 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 574521001891 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 574521001892 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 574521001893 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 574521001894 active site 574521001895 HIGH motif; other site 574521001896 nucleotide binding site [chemical binding]; other site 574521001897 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 574521001898 KMSKS motif; other site 574521001899 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 574521001900 outer membrane porin, OprD family; Region: OprD; pfam03573 574521001901 YbfN-like lipoprotein; Region: YbfN; pfam13982 574521001902 ferric uptake regulator; Provisional; Region: fur; PRK09462 574521001903 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 574521001904 metal binding site 2 [ion binding]; metal-binding site 574521001905 putative DNA binding helix; other site 574521001906 metal binding site 1 [ion binding]; metal-binding site 574521001907 dimer interface [polypeptide binding]; other site 574521001908 structural Zn2+ binding site [ion binding]; other site 574521001909 ryhB-regulated fur leader peptide; Provisional; Region: PRK14761 574521001910 flavodoxin FldA; Validated; Region: PRK09267 574521001911 LexA regulated protein; Provisional; Region: PRK11675 574521001912 acyl-CoA esterase; Provisional; Region: PRK10673 574521001913 PGAP1-like protein; Region: PGAP1; pfam07819 574521001914 replication initiation regulator SeqA; Provisional; Region: PRK11187 574521001915 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 574521001916 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 574521001917 active site 574521001918 substrate binding site [chemical binding]; other site 574521001919 metal binding site [ion binding]; metal-binding site 574521001920 putrescine transporter; Provisional; Region: potE; PRK10655 574521001921 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 574521001922 ornithine decarboxylase; Provisional; Region: PRK13578 574521001923 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 574521001924 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 574521001925 homodimer interface [polypeptide binding]; other site 574521001926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521001927 catalytic residue [active] 574521001928 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 574521001929 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 574521001930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521001931 active site 574521001932 phosphorylation site [posttranslational modification] 574521001933 intermolecular recognition site; other site 574521001934 dimerization interface [polypeptide binding]; other site 574521001935 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521001936 DNA binding site [nucleotide binding] 574521001937 sensor protein KdpD; Provisional; Region: PRK10490 574521001938 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 574521001939 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 574521001940 Ligand Binding Site [chemical binding]; other site 574521001941 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 574521001942 GAF domain; Region: GAF_3; pfam13492 574521001943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521001944 dimer interface [polypeptide binding]; other site 574521001945 phosphorylation site [posttranslational modification] 574521001946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521001947 ATP binding site [chemical binding]; other site 574521001948 Mg2+ binding site [ion binding]; other site 574521001949 G-X-G motif; other site 574521001950 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 574521001951 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 574521001952 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 574521001953 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 574521001954 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 574521001955 hypothetical protein; Provisional; Region: PRK10167 574521001956 Uncharacterized conserved protein [Function unknown]; Region: COG3272 574521001957 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 574521001958 DNA photolyase; Region: DNA_photolyase; pfam00875 574521001959 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 574521001960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521001961 putative substrate translocation pore; other site 574521001962 POT family; Region: PTR2; pfam00854 574521001963 Uncharacterized conserved protein [Function unknown]; Region: COG0327 574521001964 metal-binding protein; Provisional; Region: PRK10799 574521001965 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 574521001966 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 574521001967 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 574521001968 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 574521001969 putative active site [active] 574521001970 endonuclease VIII; Provisional; Region: PRK10445 574521001971 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 574521001972 DNA binding site [nucleotide binding] 574521001973 catalytic residue [active] 574521001974 putative catalytic residues [active] 574521001975 H2TH interface [polypeptide binding]; other site 574521001976 intercalation triad [nucleotide binding]; other site 574521001977 substrate specificity determining residue; other site 574521001978 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 574521001979 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 574521001980 Putative ammonia monooxygenase; Region: AmoA; pfam05145 574521001981 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 574521001982 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 574521001983 pseudogene, C-ter part of fimbrial-like protein 574521001984 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 574521001985 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 574521001986 dimer interface [polypeptide binding]; other site 574521001987 active site 574521001988 citrylCoA binding site [chemical binding]; other site 574521001989 NADH binding [chemical binding]; other site 574521001990 cationic pore residues; other site 574521001991 oxalacetate/citrate binding site [chemical binding]; other site 574521001992 coenzyme A binding site [chemical binding]; other site 574521001993 catalytic triad [active] 574521001994 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 574521001995 Iron-sulfur protein interface; other site 574521001996 proximal quinone binding site [chemical binding]; other site 574521001997 SdhD (CybS) interface [polypeptide binding]; other site 574521001998 proximal heme binding site [chemical binding]; other site 574521001999 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 574521002000 SdhC subunit interface [polypeptide binding]; other site 574521002001 proximal heme binding site [chemical binding]; other site 574521002002 cardiolipin binding site; other site 574521002003 Iron-sulfur protein interface; other site 574521002004 proximal quinone binding site [chemical binding]; other site 574521002005 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 574521002006 L-aspartate oxidase; Provisional; Region: PRK06175 574521002007 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 574521002008 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 574521002009 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 574521002010 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 574521002011 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 574521002012 TPP-binding site [chemical binding]; other site 574521002013 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 574521002014 dimer interface [polypeptide binding]; other site 574521002015 PYR/PP interface [polypeptide binding]; other site 574521002016 TPP binding site [chemical binding]; other site 574521002017 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 574521002018 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 574521002019 E3 interaction surface; other site 574521002020 lipoyl attachment site [posttranslational modification]; other site 574521002021 e3 binding domain; Region: E3_binding; pfam02817 574521002022 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 574521002023 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 574521002024 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 574521002025 CoA-ligase; Region: Ligase_CoA; pfam00549 574521002026 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 574521002027 CoA binding domain; Region: CoA_binding; smart00881 574521002028 CoA-ligase; Region: Ligase_CoA; pfam00549 574521002029 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 574521002030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521002031 DNA-binding site [nucleotide binding]; DNA binding site 574521002032 UTRA domain; Region: UTRA; pfam07702 574521002033 pseudogene, fused 2-O-a-mannosyl-D-glycerate specific PTS enzymes: IIA, IIB and IIC components, truncated by IS insertion 574521002034 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521002035 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 574521002036 B12 binding site [chemical binding]; other site 574521002037 heterodimer interface [polypeptide binding]; other site 574521002038 cobalt ligand [ion binding]; other site 574521002039 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 574521002040 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 574521002041 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 574521002042 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 574521002043 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 574521002044 hypothetical protein; Provisional; Region: PRK10588 574521002045 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 574521002046 active site 574521002047 colicin uptake protein TolQ; Provisional; Region: PRK10801 574521002048 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 574521002049 colicin uptake protein TolR; Provisional; Region: PRK11024 574521002050 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 574521002051 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 574521002052 TolA C-terminal; Region: TolA; pfam06519 574521002053 translocation protein TolB; Provisional; Region: tolB; PRK03629 574521002054 TolB amino-terminal domain; Region: TolB_N; pfam04052 574521002055 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 574521002056 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 574521002057 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 574521002058 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 574521002059 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 574521002060 ligand binding site [chemical binding]; other site 574521002061 tol-pal system protein YbgF; Provisional; Region: PRK10803 574521002062 Tetratricopeptide repeat; Region: TPR_6; pfam13174 574521002063 Tetratricopeptide repeat; Region: TPR_6; pfam13174 574521002064 quinolinate synthetase; Provisional; Region: PRK09375 574521002065 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 574521002066 zinc transporter ZitB; Provisional; Region: PRK03557 574521002067 YbgS-like protein; Region: YbgS; pfam13985 574521002068 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 574521002069 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 574521002070 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 574521002071 catalytic core [active] 574521002072 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 574521002073 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 574521002074 active site 574521002075 catalytic residues [active] 574521002076 galactokinase; Provisional; Region: PRK05101 574521002077 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 574521002078 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 574521002079 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 574521002080 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 574521002081 dimer interface [polypeptide binding]; other site 574521002082 active site 574521002083 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 574521002084 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 574521002085 NAD binding site [chemical binding]; other site 574521002086 homodimer interface [polypeptide binding]; other site 574521002087 active site 574521002088 substrate binding site [chemical binding]; other site 574521002089 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 574521002090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 574521002091 Walker A/P-loop; other site 574521002092 ATP binding site [chemical binding]; other site 574521002093 Q-loop/lid; other site 574521002094 ABC transporter signature motif; other site 574521002095 Walker B; other site 574521002096 D-loop; other site 574521002097 H-loop/switch region; other site 574521002098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521002099 Walker A/P-loop; other site 574521002100 ATP binding site [chemical binding]; other site 574521002101 Q-loop/lid; other site 574521002102 ABC transporter signature motif; other site 574521002103 Walker B; other site 574521002104 D-loop; other site 574521002105 H-loop/switch region; other site 574521002106 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 574521002107 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 574521002108 molybdenum-pterin binding domain; Region: Mop; TIGR00638 574521002109 TOBE domain; Region: TOBE; pfam03459 574521002110 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 574521002111 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 574521002112 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521002113 substrate binding pocket [chemical binding]; other site 574521002114 membrane-bound complex binding site; other site 574521002115 hinge residues; other site 574521002116 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 574521002117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521002118 dimer interface [polypeptide binding]; other site 574521002119 conserved gate region; other site 574521002120 putative PBP binding loops; other site 574521002121 ABC-ATPase subunit interface; other site 574521002122 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 574521002123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521002124 Walker A/P-loop; other site 574521002125 ATP binding site [chemical binding]; other site 574521002126 Q-loop/lid; other site 574521002127 ABC transporter signature motif; other site 574521002128 Walker B; other site 574521002129 D-loop; other site 574521002130 H-loop/switch region; other site 574521002131 molybdenum-pterin binding domain; Region: Mop; TIGR00638 574521002132 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 574521002133 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521002134 motif II; other site 574521002135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521002136 6-phosphogluconolactonase; Provisional; Region: PRK11028 574521002137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 574521002138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521002139 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 574521002140 putative dimerization interface [polypeptide binding]; other site 574521002141 PrpF protein; Region: PrpF; pfam04303 574521002142 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 574521002143 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 574521002144 transmembrane helices; other site 574521002145 putative hydratase; Provisional; Region: PRK11413 574521002146 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 574521002147 substrate binding site [chemical binding]; other site 574521002148 ligand binding site [chemical binding]; other site 574521002149 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 574521002150 substrate binding site [chemical binding]; other site 574521002151 acyl-CoA thioesterase; Provisional; Region: PRK10531 574521002152 putative pectinesterase; Region: PLN02432; cl01911 574521002153 prophage E2348_PP2, lambdoid 574521002154 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 574521002155 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 574521002156 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 574521002157 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 574521002158 dimer interface [polypeptide binding]; other site 574521002159 active site 574521002160 Int/Topo IB signature motif; other site 574521002161 Excisionase-like protein; Region: Exc; pfam07825 574521002162 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 574521002163 Protein of unknown function (DUF551); Region: DUF551; pfam04448 574521002164 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 574521002165 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 574521002166 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 574521002167 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 574521002168 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 574521002169 dimer interface [polypeptide binding]; other site 574521002170 ssDNA binding site [nucleotide binding]; other site 574521002171 tetramer (dimer of dimers) interface [polypeptide binding]; other site 574521002172 putative single-stranded DNA-binding protein; Region: PHA01740 574521002173 HNH endonuclease; Region: HNH_3; pfam13392 574521002174 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 574521002175 DNA-binding interface [nucleotide binding]; DNA binding site 574521002176 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 574521002177 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 574521002178 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521002179 non-specific DNA binding site [nucleotide binding]; other site 574521002180 salt bridge; other site 574521002181 sequence-specific DNA binding site [nucleotide binding]; other site 574521002182 Predicted transcriptional regulator [Transcription]; Region: COG2932 574521002183 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 574521002184 Catalytic site [active] 574521002185 Helix-turn-helix domain; Region: HTH_17; pfam12728 574521002186 Bacteriophage CII protein; Region: Phage_CII; pfam05269 574521002187 Helix-turn-helix domain; Region: HTH_36; pfam13730 574521002188 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 574521002189 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 574521002190 active site 574521002191 metal binding site [ion binding]; metal-binding site 574521002192 interdomain interaction site; other site 574521002193 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 574521002194 Walker A motif; other site 574521002195 ATP binding site [chemical binding]; other site 574521002196 AAA domain; Region: AAA_25; pfam13481 574521002197 Walker B motif; other site 574521002198 NinB protein; Region: NinB; pfam05772 574521002199 NINE Protein; Region: NinE; pfam05322 574521002200 NinF protein; Region: NinF; pfam05810 574521002201 HNH endonuclease; Region: HNH_3; pfam13392 574521002202 AP2 domain; Region: AP2; pfam00847 574521002203 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 574521002204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 574521002205 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 574521002206 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 574521002207 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 574521002208 Domain of unknown function (DUF303); Region: DUF303; pfam03629 574521002209 Lysis protein S; Region: Lysis_S; pfam04971 574521002210 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 574521002211 catalytic residues [active] 574521002212 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 574521002213 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 574521002214 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 574521002215 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 574521002216 ORF11CD3 domain; Region: ORF11CD3; pfam10549 574521002217 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 574521002218 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 574521002219 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 574521002220 gpW; Region: gpW; pfam02831 574521002221 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 574521002222 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 574521002223 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 574521002224 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 574521002225 tandem repeat interface [polypeptide binding]; other site 574521002226 oligomer interface [polypeptide binding]; other site 574521002227 active site residues [active] 574521002228 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 574521002229 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 574521002230 DNA packaging protein FI; Region: Packaging_FI; pfam14000 574521002231 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 574521002232 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 574521002233 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 574521002234 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 574521002235 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 574521002236 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 574521002237 Minor tail protein T; Region: Phage_tail_T; cl05636 574521002238 Phage-related minor tail protein [Function unknown]; Region: COG5281 574521002239 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 574521002240 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 574521002241 Phage-related protein [Function unknown]; Region: COG4718 574521002242 Phage-related protein [Function unknown]; Region: gp18; COG4672 574521002243 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 574521002244 MPN+ (JAMM) motif; other site 574521002245 Zinc-binding site [ion binding]; other site 574521002246 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 574521002247 NlpC/P60 family; Region: NLPC_P60; cl17555 574521002248 Phage-related protein, tail component [Function unknown]; Region: COG4723 574521002249 Phage-related protein, tail component [Function unknown]; Region: COG4733 574521002250 Putative phage tail protein; Region: Phage-tail_3; pfam13550 574521002251 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 574521002252 Fibronectin type III protein; Region: DUF3672; pfam12421 574521002253 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 574521002254 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 574521002255 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 574521002256 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 574521002257 E2348_PP2; pseudogene, T3SS effector Cif, truncated by IS insertion 574521002258 E2348_PP2; pseudogene, N-ter part of transposase Orf2 of IS2 574521002259 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 574521002260 substrate binding site [chemical binding]; other site 574521002261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 574521002262 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 574521002263 Probable transposase; Region: OrfB_IS605; pfam01385 574521002264 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 574521002265 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 574521002266 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 574521002267 inhibitor-cofactor binding pocket; inhibition site 574521002268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521002269 catalytic residue [active] 574521002270 biotin synthase; Provisional; Region: PRK15108 574521002271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521002272 FeS/SAM binding site; other site 574521002273 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 574521002274 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 574521002275 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 574521002276 substrate-cofactor binding pocket; other site 574521002277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521002278 catalytic residue [active] 574521002279 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 574521002280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521002281 S-adenosylmethionine binding site [chemical binding]; other site 574521002282 AAA domain; Region: AAA_26; pfam13500 574521002283 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 574521002284 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 574521002285 ADP binding site [chemical binding]; other site 574521002286 excinuclease ABC subunit B; Provisional; Region: PRK05298 574521002287 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 574521002288 ATP binding site [chemical binding]; other site 574521002289 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521002290 nucleotide binding region [chemical binding]; other site 574521002291 ATP-binding site [chemical binding]; other site 574521002292 Ultra-violet resistance protein B; Region: UvrB; pfam12344 574521002293 UvrB/uvrC motif; Region: UVR; pfam02151 574521002294 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 574521002295 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 574521002296 putative substrate binding pocket [chemical binding]; other site 574521002297 dimer interface [polypeptide binding]; other site 574521002298 phosphate binding site [ion binding]; other site 574521002299 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 574521002300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521002301 FeS/SAM binding site; other site 574521002302 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 574521002303 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 574521002304 MPT binding site; other site 574521002305 trimer interface [polypeptide binding]; other site 574521002306 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 574521002307 trimer interface [polypeptide binding]; other site 574521002308 dimer interface [polypeptide binding]; other site 574521002309 putative active site [active] 574521002310 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 574521002311 MoaE interaction surface [polypeptide binding]; other site 574521002312 MoeB interaction surface [polypeptide binding]; other site 574521002313 thiocarboxylated glycine; other site 574521002314 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 574521002315 MoaE homodimer interface [polypeptide binding]; other site 574521002316 MoaD interaction [polypeptide binding]; other site 574521002317 active site residues [active] 574521002318 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 574521002319 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 574521002320 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 574521002321 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 574521002322 Predicted integral membrane protein [Function unknown]; Region: COG0392 574521002323 cardiolipin synthase 2; Provisional; Region: PRK11263 574521002324 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 574521002325 putative active site [active] 574521002326 catalytic site [active] 574521002327 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 574521002328 putative active site [active] 574521002329 catalytic site [active] 574521002330 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 574521002331 putative catalytic site [active] 574521002332 putative metal binding site [ion binding]; other site 574521002333 putative phosphate binding site [ion binding]; other site 574521002334 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 574521002335 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 574521002336 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 574521002337 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 574521002338 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 574521002339 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 574521002340 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 574521002341 Walker A/P-loop; other site 574521002342 ATP binding site [chemical binding]; other site 574521002343 Q-loop/lid; other site 574521002344 ABC transporter signature motif; other site 574521002345 Walker B; other site 574521002346 D-loop; other site 574521002347 H-loop/switch region; other site 574521002348 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 574521002349 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 574521002350 Walker A/P-loop; other site 574521002351 ATP binding site [chemical binding]; other site 574521002352 Q-loop/lid; other site 574521002353 ABC transporter signature motif; other site 574521002354 Walker B; other site 574521002355 D-loop; other site 574521002356 H-loop/switch region; other site 574521002357 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 574521002358 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521002359 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521002360 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 574521002361 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 574521002362 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 574521002363 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 574521002364 ATP binding site [chemical binding]; other site 574521002365 Mg++ binding site [ion binding]; other site 574521002366 motif III; other site 574521002367 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521002368 nucleotide binding region [chemical binding]; other site 574521002369 ATP-binding site [chemical binding]; other site 574521002370 pseudogene, C-ter part of conserved protein 574521002371 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 574521002372 DEAD_2; Region: DEAD_2; pfam06733 574521002373 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 574521002374 glycosyl transferase family protein; Provisional; Region: PRK08136 574521002375 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 574521002376 putative dehydrogenase; Provisional; Region: PRK10098 574521002377 hypothetical protein; Provisional; Region: PRK10259 574521002378 hypothetical protein; Provisional; Region: PRK11019 574521002379 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 574521002380 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 574521002381 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 574521002382 N-terminal plug; other site 574521002383 ligand-binding site [chemical binding]; other site 574521002384 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 574521002385 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 574521002386 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 574521002387 putative mechanosensitive channel protein; Provisional; Region: PRK11465 574521002388 Mechanosensitive ion channel; Region: MS_channel; pfam00924 574521002389 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 574521002390 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 574521002391 Walker A/P-loop; other site 574521002392 ATP binding site [chemical binding]; other site 574521002393 Q-loop/lid; other site 574521002394 ABC transporter signature motif; other site 574521002395 Walker B; other site 574521002396 D-loop; other site 574521002397 H-loop/switch region; other site 574521002398 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 574521002399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521002400 dimer interface [polypeptide binding]; other site 574521002401 conserved gate region; other site 574521002402 putative PBP binding loops; other site 574521002403 ABC-ATPase subunit interface; other site 574521002404 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 574521002405 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521002406 substrate binding pocket [chemical binding]; other site 574521002407 membrane-bound complex binding site; other site 574521002408 hinge residues; other site 574521002409 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 574521002410 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 574521002411 dimerization interface [polypeptide binding]; other site 574521002412 DPS ferroxidase diiron center [ion binding]; other site 574521002413 ion pore; other site 574521002414 threonine and homoserine efflux system; Provisional; Region: PRK10532 574521002415 EamA-like transporter family; Region: EamA; pfam00892 574521002416 outer membrane protein X; Provisional; Region: ompX; PRK09408 574521002417 Transposase IS200 like; Region: Y1_Tnp; pfam01797 574521002418 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 574521002419 Sulfatase; Region: Sulfatase; pfam00884 574521002420 manganese transport regulator MntR; Provisional; Region: PRK11050 574521002421 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 574521002422 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 574521002423 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 574521002424 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 574521002425 transmembrane helices; other site 574521002426 L,D-transpeptidase; Provisional; Region: PRK10260 574521002427 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 574521002428 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 574521002429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521002430 Walker A/P-loop; other site 574521002431 ATP binding site [chemical binding]; other site 574521002432 Q-loop/lid; other site 574521002433 ABC transporter signature motif; other site 574521002434 Walker B; other site 574521002435 D-loop; other site 574521002436 H-loop/switch region; other site 574521002437 ABC transporter; Region: ABC_tran_2; pfam12848 574521002438 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 574521002439 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 574521002440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521002441 active site 574521002442 motif I; other site 574521002443 motif II; other site 574521002444 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521002445 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 574521002446 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 574521002447 dimer interface [polypeptide binding]; other site 574521002448 active site 574521002449 glycine loop; other site 574521002450 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 574521002451 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 574521002452 active site 574521002453 intersubunit interactions; other site 574521002454 catalytic residue [active] 574521002455 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 574521002456 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 574521002457 ATP binding site [chemical binding]; other site 574521002458 substrate interface [chemical binding]; other site 574521002459 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 574521002460 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 574521002461 dimer interface [polypeptide binding]; other site 574521002462 putative functional site; other site 574521002463 putative MPT binding site; other site 574521002464 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 574521002465 catalytic nucleophile [active] 574521002466 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 574521002467 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521002468 Walker A/P-loop; other site 574521002469 ATP binding site [chemical binding]; other site 574521002470 Q-loop/lid; other site 574521002471 ABC transporter signature motif; other site 574521002472 Walker B; other site 574521002473 D-loop; other site 574521002474 H-loop/switch region; other site 574521002475 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 574521002476 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521002477 Walker A/P-loop; other site 574521002478 ATP binding site [chemical binding]; other site 574521002479 Q-loop/lid; other site 574521002480 ABC transporter signature motif; other site 574521002481 Walker B; other site 574521002482 D-loop; other site 574521002483 H-loop/switch region; other site 574521002484 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 574521002485 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 574521002486 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 574521002487 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 574521002488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521002489 dimer interface [polypeptide binding]; other site 574521002490 conserved gate region; other site 574521002491 putative PBP binding loops; other site 574521002492 ABC-ATPase subunit interface; other site 574521002493 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 574521002494 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 574521002495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521002496 dimer interface [polypeptide binding]; other site 574521002497 conserved gate region; other site 574521002498 putative PBP binding loops; other site 574521002499 ABC-ATPase subunit interface; other site 574521002500 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521002501 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 574521002502 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 574521002503 metal binding site [ion binding]; metal-binding site 574521002504 active site 574521002505 I-site; other site 574521002506 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 574521002507 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 574521002508 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521002509 FeS/SAM binding site; other site 574521002510 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 574521002511 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 574521002512 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 574521002513 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 574521002514 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 574521002515 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 574521002516 N-terminal domain interface [polypeptide binding]; other site 574521002517 dimer interface [polypeptide binding]; other site 574521002518 substrate binding pocket (H-site) [chemical binding]; other site 574521002519 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 574521002520 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 574521002521 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 574521002522 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 574521002523 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 574521002524 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 574521002525 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 574521002526 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 574521002527 active site 574521002528 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 574521002529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521002530 putative substrate translocation pore; other site 574521002531 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 574521002532 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521002533 active site 574521002534 motif I; other site 574521002535 motif II; other site 574521002536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521002537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521002538 putative substrate translocation pore; other site 574521002539 Major Facilitator Superfamily; Region: MFS_1; pfam07690 574521002540 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 574521002541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521002542 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 574521002543 prophage E2348_PP3, P2-like 574521002544 integrase; Provisional; Region: int; PHA02601 574521002545 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 574521002546 active site 574521002547 DNA binding site [nucleotide binding] 574521002548 Int/Topo IB signature motif; other site 574521002549 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 574521002550 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 574521002551 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 574521002552 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 574521002553 Predicted transcriptional regulator [Transcription]; Region: COG2932 574521002554 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 574521002555 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 574521002556 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 574521002557 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 574521002558 DksA-like zinc finger domain containing protein; Region: PHA00080 574521002559 DNA adenine methylase (dam); Region: dam; TIGR00571 574521002560 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 574521002561 DinI-like family; Region: DinI; pfam06183 574521002562 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 574521002563 active site 574521002564 DNA protecting protein DprA; Region: dprA; TIGR00732 574521002565 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 574521002566 portal vertex protein; Provisional; Region: Q; PHA02536 574521002567 Phage portal protein; Region: Phage_portal; pfam04860 574521002568 terminase ATPase subunit; Provisional; Region: P; PHA02535 574521002569 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 574521002570 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 574521002571 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 574521002572 capsid protein; Provisional; Region: N; PHA02538 574521002573 terminase endonuclease subunit; Provisional; Region: M; PHA02537 574521002574 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 574521002575 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 574521002576 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 574521002577 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 574521002578 catalytic residues [active] 574521002579 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 574521002580 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 574521002582 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 574521002583 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 574521002584 baseplate assembly protein; Provisional; Region: J; PHA02568 574521002585 baseplate wedge subunit; Provisional; Region: W; PHA02516 574521002586 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 574521002587 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 574521002588 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 574521002589 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 574521002590 catalytic residues [active] 574521002591 catalytic nucleophile [active] 574521002592 Presynaptic Site I dimer interface [polypeptide binding]; other site 574521002593 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 574521002594 Synaptic Flat tetramer interface [polypeptide binding]; other site 574521002595 Synaptic Site I dimer interface [polypeptide binding]; other site 574521002596 DNA binding site [nucleotide binding] 574521002597 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 574521002598 DNA-binding interface [nucleotide binding]; DNA binding site 574521002599 major tail sheath protein; Provisional; Region: FI; PHA02560 574521002600 major tail tube protein; Provisional; Region: FII; PHA02600 574521002601 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 574521002602 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 574521002603 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 574521002604 Phage protein U [General function prediction only]; Region: COG3499 574521002605 tail protein; Provisional; Region: D; PHA02561 574521002606 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 574521002607 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 574521002608 putative transporter; Provisional; Region: PRK04972 574521002609 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 574521002610 TrkA-C domain; Region: TrkA_C; pfam02080 574521002611 TrkA-C domain; Region: TrkA_C; pfam02080 574521002612 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 574521002613 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 574521002614 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 574521002615 GSH binding site [chemical binding]; other site 574521002616 catalytic residues [active] 574521002617 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 574521002618 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 574521002619 dimer interface [polypeptide binding]; other site 574521002620 FMN binding site [chemical binding]; other site 574521002621 NADPH bind site [chemical binding]; other site 574521002622 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 574521002623 RimK-like ATP-grasp domain; Region: RimK; pfam08443 574521002624 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 574521002625 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 574521002626 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 574521002627 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 574521002628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521002629 Walker A/P-loop; other site 574521002630 ATP binding site [chemical binding]; other site 574521002631 Q-loop/lid; other site 574521002632 ABC transporter signature motif; other site 574521002633 Walker B; other site 574521002634 D-loop; other site 574521002635 H-loop/switch region; other site 574521002636 TOBE domain; Region: TOBE_2; pfam08402 574521002637 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 574521002638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521002639 dimer interface [polypeptide binding]; other site 574521002640 conserved gate region; other site 574521002641 putative PBP binding loops; other site 574521002642 ABC-ATPase subunit interface; other site 574521002643 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 574521002644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521002645 dimer interface [polypeptide binding]; other site 574521002646 conserved gate region; other site 574521002647 putative PBP binding loops; other site 574521002648 ABC-ATPase subunit interface; other site 574521002649 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 574521002650 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 574521002651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521002652 S-adenosylmethionine binding site [chemical binding]; other site 574521002653 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 574521002654 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521002655 substrate binding pocket [chemical binding]; other site 574521002656 membrane-bound complex binding site; other site 574521002657 hinge residues; other site 574521002658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521002659 dimer interface [polypeptide binding]; other site 574521002660 conserved gate region; other site 574521002661 putative PBP binding loops; other site 574521002662 ABC-ATPase subunit interface; other site 574521002663 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 574521002664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521002665 dimer interface [polypeptide binding]; other site 574521002666 conserved gate region; other site 574521002667 putative PBP binding loops; other site 574521002668 ABC-ATPase subunit interface; other site 574521002669 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 574521002670 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521002671 substrate binding pocket [chemical binding]; other site 574521002672 membrane-bound complex binding site; other site 574521002673 hinge residues; other site 574521002674 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 574521002675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521002676 Walker A/P-loop; other site 574521002677 ATP binding site [chemical binding]; other site 574521002678 Q-loop/lid; other site 574521002679 ABC transporter signature motif; other site 574521002680 Walker B; other site 574521002681 D-loop; other site 574521002682 H-loop/switch region; other site 574521002683 putative lipoprotein; Provisional; Region: PRK10533 574521002684 hypothetical protein; Provisional; Region: PRK02877 574521002685 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 574521002686 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 574521002687 amidase catalytic site [active] 574521002688 Zn binding residues [ion binding]; other site 574521002689 substrate binding site [chemical binding]; other site 574521002690 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 574521002691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 574521002692 NAD(P) binding site [chemical binding]; other site 574521002693 active site 574521002694 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 574521002695 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 574521002696 putative NAD(P) binding site [chemical binding]; other site 574521002697 putative active site [active] 574521002698 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 574521002699 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 574521002700 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 574521002701 tetramer interface [polypeptide binding]; other site 574521002702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521002703 catalytic residue [active] 574521002704 pyruvate dehydrogenase; Provisional; Region: PRK09124 574521002705 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 574521002706 PYR/PP interface [polypeptide binding]; other site 574521002707 dimer interface [polypeptide binding]; other site 574521002708 tetramer interface [polypeptide binding]; other site 574521002709 TPP binding site [chemical binding]; other site 574521002710 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 574521002711 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 574521002712 TPP-binding site [chemical binding]; other site 574521002713 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 574521002714 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 574521002715 FAD binding pocket [chemical binding]; other site 574521002716 FAD binding motif [chemical binding]; other site 574521002717 phosphate binding motif [ion binding]; other site 574521002718 beta-alpha-beta structure motif; other site 574521002719 NAD binding pocket [chemical binding]; other site 574521002720 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 574521002721 catalytic loop [active] 574521002722 iron binding site [ion binding]; other site 574521002723 hybrid cluster protein; Provisional; Region: PRK05290 574521002724 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 574521002725 ACS interaction site; other site 574521002726 CODH interaction site; other site 574521002727 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 574521002728 hybrid metal cluster; other site 574521002729 Predicted membrane protein [Function unknown]; Region: COG2431 574521002730 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 574521002731 amphipathic channel; other site 574521002732 Asn-Pro-Ala signature motifs; other site 574521002733 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 574521002734 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 574521002735 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 574521002736 putative active site [active] 574521002737 putative metal-binding site [ion binding]; other site 574521002738 Protein of unknown function (DUF535); Region: DUF535; pfam04393 574521002739 macrolide transporter subunit MacA; Provisional; Region: PRK11578 574521002740 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521002741 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521002742 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 574521002743 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 574521002744 Walker A/P-loop; other site 574521002745 ATP binding site [chemical binding]; other site 574521002746 Q-loop/lid; other site 574521002747 ABC transporter signature motif; other site 574521002748 Walker B; other site 574521002749 D-loop; other site 574521002750 H-loop/switch region; other site 574521002751 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 574521002752 FtsX-like permease family; Region: FtsX; pfam02687 574521002753 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 574521002754 DNA-binding site [nucleotide binding]; DNA binding site 574521002755 RNA-binding motif; other site 574521002756 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 574521002757 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 574521002758 Clp amino terminal domain; Region: Clp_N; pfam02861 574521002759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521002760 Walker A motif; other site 574521002761 ATP binding site [chemical binding]; other site 574521002762 Walker B motif; other site 574521002763 arginine finger; other site 574521002764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521002765 Walker A motif; other site 574521002766 ATP binding site [chemical binding]; other site 574521002767 Walker B motif; other site 574521002768 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 574521002769 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 574521002770 rRNA binding site [nucleotide binding]; other site 574521002771 predicted 30S ribosome binding site; other site 574521002772 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 574521002773 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 574521002774 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 574521002775 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 574521002776 Walker A/P-loop; other site 574521002777 ATP binding site [chemical binding]; other site 574521002778 Q-loop/lid; other site 574521002779 ABC transporter signature motif; other site 574521002780 Walker B; other site 574521002781 D-loop; other site 574521002782 H-loop/switch region; other site 574521002783 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 574521002784 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 574521002785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521002786 Walker A/P-loop; other site 574521002787 ATP binding site [chemical binding]; other site 574521002788 Q-loop/lid; other site 574521002789 ABC transporter signature motif; other site 574521002790 Walker B; other site 574521002791 D-loop; other site 574521002792 H-loop/switch region; other site 574521002793 thioredoxin reductase; Provisional; Region: PRK10262 574521002794 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 574521002795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521002796 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 574521002797 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 574521002798 putative DNA binding site [nucleotide binding]; other site 574521002799 putative Zn2+ binding site [ion binding]; other site 574521002800 AsnC family; Region: AsnC_trans_reg; pfam01037 574521002801 DNA translocase FtsK; Provisional; Region: PRK10263 574521002802 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 574521002803 DNA translocase FtsK; Provisional; Region: PRK10263 574521002804 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 574521002805 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 574521002806 periplasmic chaperone LolA; Region: lolA; TIGR00547 574521002807 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 574521002808 recombination factor protein RarA; Reviewed; Region: PRK13342 574521002809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521002810 Walker A motif; other site 574521002811 ATP binding site [chemical binding]; other site 574521002812 Walker B motif; other site 574521002813 arginine finger; other site 574521002814 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 574521002815 seryl-tRNA synthetase; Provisional; Region: PRK05431 574521002816 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 574521002817 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 574521002818 dimer interface [polypeptide binding]; other site 574521002819 active site 574521002820 motif 1; other site 574521002821 motif 2; other site 574521002822 motif 3; other site 574521002823 pseudogene, dimethyl sulfoxide reductase, anaerobic, subunit A, truncated by premature stop codon 574521002824 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 574521002825 4Fe-4S binding domain; Region: Fer4; pfam00037 574521002826 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 574521002827 pseudogene, hydrolase, N-ter part missing 574521002828 putative MFS family transporter protein; Provisional; Region: PRK03633 574521002829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521002830 putative substrate translocation pore; other site 574521002831 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 574521002832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521002833 FeS/SAM binding site; other site 574521002834 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 574521002835 Pyruvate formate lyase 1; Region: PFL1; cd01678 574521002836 coenzyme A binding site [chemical binding]; other site 574521002837 active site 574521002838 catalytic residues [active] 574521002839 glycine loop; other site 574521002840 formate transporter; Provisional; Region: PRK10805 574521002841 uncharacterized domain; Region: TIGR00702 574521002842 YcaO-like family; Region: YcaO; pfam02624 574521002843 Predicted membrane protein [Function unknown]; Region: COG2323 574521002844 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 574521002845 homodimer interface [polypeptide binding]; other site 574521002846 substrate-cofactor binding pocket; other site 574521002847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521002848 catalytic residue [active] 574521002849 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 574521002850 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 574521002851 hinge; other site 574521002852 active site 574521002853 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 574521002854 cytidylate kinase; Provisional; Region: cmk; PRK00023 574521002855 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 574521002856 CMP-binding site; other site 574521002857 The sites determining sugar specificity; other site 574521002858 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 574521002859 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 574521002860 RNA binding site [nucleotide binding]; other site 574521002861 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 574521002862 RNA binding site [nucleotide binding]; other site 574521002863 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 574521002864 RNA binding site [nucleotide binding]; other site 574521002865 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 574521002866 RNA binding site [nucleotide binding]; other site 574521002867 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 574521002868 RNA binding site [nucleotide binding]; other site 574521002869 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 574521002870 IHF dimer interface [polypeptide binding]; other site 574521002871 IHF - DNA interface [nucleotide binding]; other site 574521002872 ComEC family competence protein; Provisional; Region: PRK11539 574521002873 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 574521002874 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 574521002875 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 574521002876 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 574521002877 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 574521002878 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 574521002879 Walker A/P-loop; other site 574521002880 ATP binding site [chemical binding]; other site 574521002881 Q-loop/lid; other site 574521002882 ABC transporter signature motif; other site 574521002883 Walker B; other site 574521002884 D-loop; other site 574521002885 H-loop/switch region; other site 574521002886 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 574521002887 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 574521002888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 574521002889 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 574521002890 hypothetical protein; Provisional; Region: PRK11827 574521002891 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 574521002892 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 574521002893 Ligand binding site; other site 574521002894 oligomer interface; other site 574521002895 hypothetical protein; Provisional; Region: PRK10593 574521002896 Uncharacterized conserved protein [Function unknown]; Region: COG1434 574521002897 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 574521002898 putative active site [active] 574521002899 Methyltransferase domain; Region: Methyltransf_31; pfam13847 574521002900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521002901 S-adenosylmethionine binding site [chemical binding]; other site 574521002902 condesin subunit F; Provisional; Region: PRK05260 574521002903 condesin subunit E; Provisional; Region: PRK05256 574521002904 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 574521002905 MukB N-terminal; Region: MukB; pfam04310 574521002906 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 574521002907 murein L,D-transpeptidase; Provisional; Region: PRK10594 574521002908 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 574521002909 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 574521002910 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 574521002911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 574521002912 Peptidase M15; Region: Peptidase_M15_3; cl01194 574521002913 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 574521002914 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 574521002915 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 574521002916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521002917 homodimer interface [polypeptide binding]; other site 574521002918 catalytic residue [active] 574521002919 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 574521002920 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 574521002921 trimer interface [polypeptide binding]; other site 574521002922 eyelet of channel; other site 574521002923 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 574521002924 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 574521002925 putative dimer interface [polypeptide binding]; other site 574521002926 putative anticodon binding site; other site 574521002927 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 574521002928 homodimer interface [polypeptide binding]; other site 574521002929 motif 1; other site 574521002930 motif 2; other site 574521002931 active site 574521002932 motif 3; other site 574521002933 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 574521002934 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 574521002935 active site 574521002936 aminopeptidase N; Provisional; Region: pepN; PRK14015 574521002937 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 574521002938 active site 574521002939 Zn binding site [ion binding]; other site 574521002940 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 574521002941 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 574521002942 Walker A/P-loop; other site 574521002943 ATP binding site [chemical binding]; other site 574521002944 Q-loop/lid; other site 574521002945 ABC transporter signature motif; other site 574521002946 Walker B; other site 574521002947 D-loop; other site 574521002948 H-loop/switch region; other site 574521002949 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 574521002950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521002951 dimer interface [polypeptide binding]; other site 574521002952 conserved gate region; other site 574521002953 putative PBP binding loops; other site 574521002954 ABC-ATPase subunit interface; other site 574521002955 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 574521002956 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 574521002957 active site 574521002958 dimer interface [polypeptide binding]; other site 574521002959 non-prolyl cis peptide bond; other site 574521002960 insertion regions; other site 574521002961 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521002962 substrate binding pocket [chemical binding]; other site 574521002963 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 574521002964 membrane-bound complex binding site; other site 574521002965 hinge residues; other site 574521002966 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 574521002967 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 574521002968 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 574521002969 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 574521002970 quinone interaction residues [chemical binding]; other site 574521002971 active site 574521002972 catalytic residues [active] 574521002973 FMN binding site [chemical binding]; other site 574521002974 substrate binding site [chemical binding]; other site 574521002975 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 574521002976 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 574521002977 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 574521002978 MOSC domain; Region: MOSC; pfam03473 574521002979 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 574521002980 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 574521002981 catalytic loop [active] 574521002982 iron binding site [ion binding]; other site 574521002983 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 574521002984 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 574521002985 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 574521002986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521002987 S-adenosylmethionine binding site [chemical binding]; other site 574521002988 ABC transporter ATPase component; Reviewed; Region: PRK11147 574521002989 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521002990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521002991 Walker A/P-loop; other site 574521002992 Walker A/P-loop; other site 574521002993 ATP binding site [chemical binding]; other site 574521002994 ATP binding site [chemical binding]; other site 574521002995 Q-loop/lid; other site 574521002996 Q-loop/lid; other site 574521002997 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 574521002998 ABC transporter signature motif; other site 574521002999 Walker B; other site 574521003000 D-loop; other site 574521003001 ABC transporter; Region: ABC_tran_2; pfam12848 574521003002 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 574521003003 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 574521003004 Paraquat-inducible protein A; Region: PqiA; pfam04403 574521003005 Paraquat-inducible protein A; Region: PqiA; pfam04403 574521003006 paraquat-inducible protein B; Provisional; Region: PRK10807 574521003007 mce related protein; Region: MCE; pfam02470 574521003008 mce related protein; Region: MCE; pfam02470 574521003009 mce related protein; Region: MCE; pfam02470 574521003010 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 574521003011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 574521003012 Protein of unknown function (DUF330); Region: DUF330; pfam03886 574521003013 ribosome modulation factor; Provisional; Region: PRK14563 574521003014 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 574521003015 active site 1 [active] 574521003016 dimer interface [polypeptide binding]; other site 574521003017 active site 2 [active] 574521003018 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 574521003019 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 574521003020 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 574521003021 outer membrane protein A; Reviewed; Region: PRK10808 574521003022 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 574521003023 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 574521003024 ligand binding site [chemical binding]; other site 574521003025 cell division inhibitor SulA; Region: sula; TIGR00623 574521003026 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 574521003027 TfoX C-terminal domain; Region: TfoX_C; pfam04994 574521003028 TIGR01666 family membrane protein; Region: YCCS 574521003029 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 574521003030 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 574521003031 Predicted membrane protein [Function unknown]; Region: COG3304 574521003032 Domain of unknown function (DUF307); Region: DUF307; pfam03733 574521003033 Domain of unknown function (DUF307); Region: DUF307; pfam03733 574521003034 DNA helicase IV; Provisional; Region: helD; PRK11054 574521003035 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 574521003036 Part of AAA domain; Region: AAA_19; pfam13245 574521003037 Family description; Region: UvrD_C_2; pfam13538 574521003038 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 574521003039 active site 574521003040 dimer interfaces [polypeptide binding]; other site 574521003041 catalytic residues [active] 574521003042 hypothetical protein; Provisional; Region: PRK03641 574521003043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 574521003044 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 574521003045 heat shock protein HspQ; Provisional; Region: PRK14129 574521003046 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 574521003047 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 574521003048 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 574521003049 putative RNA binding site [nucleotide binding]; other site 574521003050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521003051 S-adenosylmethionine binding site [chemical binding]; other site 574521003052 Acylphosphatase; Region: Acylphosphatase; cl00551 574521003053 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 574521003054 sulfur transfer protein TusE; Provisional; Region: PRK11508 574521003055 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 574521003056 YccA-like proteins; Region: YccA_like; cd10433 574521003057 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 574521003058 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 574521003059 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 574521003060 hydrogenase 1 large subunit; Provisional; Region: PRK10170 574521003061 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 574521003062 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 574521003063 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 574521003064 putative substrate-binding site; other site 574521003065 nickel binding site [ion binding]; other site 574521003066 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 574521003067 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 574521003068 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 574521003069 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 574521003070 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 574521003071 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 574521003072 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 574521003073 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 574521003074 catalytic core [active] 574521003075 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 574521003076 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 574521003077 Chain length determinant protein; Region: Wzz; pfam02706 574521003078 Chain length determinant protein; Region: Wzz; cl15801 574521003079 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 574521003080 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 574521003081 Nucleotide binding site [chemical binding]; other site 574521003082 Low molecular weight phosphatase family; Region: LMWPc; cd00115 574521003083 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 574521003084 active site 574521003085 polysaccharide export protein Wza; Provisional; Region: PRK15078 574521003086 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 574521003087 SLBB domain; Region: SLBB; pfam10531 574521003088 SLBB domain; Region: SLBB; pfam10531 574521003089 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 574521003090 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 574521003091 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 574521003092 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 574521003093 DNA-binding site [nucleotide binding]; DNA binding site 574521003094 RNA-binding motif; other site 574521003095 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 574521003096 DNA-binding site [nucleotide binding]; DNA binding site 574521003097 RNA-binding motif; other site 574521003098 cold shock gene; Provisional; Region: PRK09891 574521003099 GnsA/GnsB family; Region: GnsAB; pfam08178 574521003100 4Fe-4S binding domain; Region: Fer4_5; pfam12801 574521003101 4Fe-4S binding domain; Region: Fer4_5; pfam12801 574521003102 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 574521003103 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 574521003104 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 574521003105 HAMP domain; Region: HAMP; pfam00672 574521003106 dimerization interface [polypeptide binding]; other site 574521003107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521003108 dimer interface [polypeptide binding]; other site 574521003109 phosphorylation site [posttranslational modification] 574521003110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521003111 ATP binding site [chemical binding]; other site 574521003112 Mg2+ binding site [ion binding]; other site 574521003113 G-X-G motif; other site 574521003114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521003115 active site 574521003116 phosphorylation site [posttranslational modification] 574521003117 intermolecular recognition site; other site 574521003118 dimerization interface [polypeptide binding]; other site 574521003119 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 574521003120 putative binding surface; other site 574521003121 active site 574521003122 prophage E2348_PP4, lambdoid 574521003123 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 574521003124 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 574521003125 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 574521003126 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 574521003127 dimer interface [polypeptide binding]; other site 574521003128 active site 574521003129 Int/Topo IB signature motif; other site 574521003130 Excisionase-like protein; Region: Exc; pfam07825 574521003131 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 574521003132 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 574521003133 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 574521003134 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 574521003135 dimer interface [polypeptide binding]; other site 574521003136 ssDNA binding site [nucleotide binding]; other site 574521003137 tetramer (dimer of dimers) interface [polypeptide binding]; other site 574521003138 putative single-stranded DNA-binding protein; Region: PHA01740 574521003139 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 574521003140 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 574521003141 cIII protein family; Region: cIII; pfam08134 574521003142 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 574521003143 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 574521003144 BRO family, N-terminal domain; Region: Bro-N; pfam02498 574521003145 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 574521003146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521003147 non-specific DNA binding site [nucleotide binding]; other site 574521003148 salt bridge; other site 574521003149 sequence-specific DNA binding site [nucleotide binding]; other site 574521003150 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 574521003151 Catalytic site [active] 574521003152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521003153 non-specific DNA binding site [nucleotide binding]; other site 574521003154 salt bridge; other site 574521003155 sequence-specific DNA binding site [nucleotide binding]; other site 574521003156 Bacteriophage CII protein; Region: Phage_CII; pfam05269 574521003157 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 574521003158 Replication protein P; Region: Phage_lambda_P; pfam06992 574521003159 NinB protein; Region: NinB; pfam05772 574521003160 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 574521003161 NINE Protein; Region: NinE; pfam05322 574521003162 NinF protein; Region: NinF; pfam05810 574521003163 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 574521003164 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 574521003165 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 574521003166 Endodeoxyribonuclease RusA; Region: RusA; cl01885 574521003167 Antitermination protein; Region: Antiterm; pfam03589 574521003168 Antitermination protein; Region: Antiterm; pfam03589 574521003169 Lysis protein S; Region: Lysis_S; pfam04971 574521003170 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 574521003171 catalytic residues [active] 574521003172 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 574521003173 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 574521003174 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 574521003175 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 574521003176 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 574521003177 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 574521003178 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 574521003179 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 574521003180 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 574521003181 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 574521003182 oligomer interface [polypeptide binding]; other site 574521003183 active site residues [active] 574521003184 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 574521003185 Uncharacterized conserved protein [Function unknown]; Region: COG5471 574521003186 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 574521003187 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 574521003188 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 574521003189 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 574521003190 Bacterial Ig-like domain 2; Region: BID_2; smart00635 574521003191 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 574521003192 Minor tail protein T; Region: Phage_tail_T; pfam06223 574521003193 E2348_PP4; pseudogene, tail length tape measure protein, truncated by frameshift mutation 574521003194 Phage-related protein [Function unknown]; Region: COG4718 574521003195 Phage-related protein [Function unknown]; Region: gp18; COG4672 574521003196 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 574521003197 MPN+ (JAMM) motif; other site 574521003198 Zinc-binding site [ion binding]; other site 574521003199 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 574521003200 NlpC/P60 family; Region: NLPC_P60; cl17555 574521003201 Phage-related protein, tail component [Function unknown]; Region: COG4723 574521003202 E2348_PP4; pseudogene, host specificity protein, truncated by frameshift mutation 574521003203 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 574521003204 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 574521003205 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 574521003206 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 574521003207 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 574521003208 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 574521003209 type III secretion system protein; Provisional; Region: PRK15384; cl14665 574521003210 NFkB-p65-degrading zinc protease; Region: Peptidase_M85; pfam13678 574521003211 E2348_PP4; pseudogene, C-ter part of T3SS secreted effector NleH homolog 574521003212 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 574521003213 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 574521003214 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 574521003215 putative ligand binding site [chemical binding]; other site 574521003216 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 574521003217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521003218 active site 574521003219 phosphorylation site [posttranslational modification] 574521003220 intermolecular recognition site; other site 574521003221 dimerization interface [polypeptide binding]; other site 574521003222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521003223 DNA binding site [nucleotide binding] 574521003224 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 574521003225 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 574521003226 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 574521003227 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 574521003228 molybdopterin cofactor binding site [chemical binding]; other site 574521003229 substrate binding site [chemical binding]; other site 574521003230 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 574521003231 molybdopterin cofactor binding site; other site 574521003232 chaperone protein TorD; Validated; Region: torD; PRK04976 574521003233 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 574521003234 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 574521003235 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 574521003236 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 574521003237 HSP70 interaction site [polypeptide binding]; other site 574521003238 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 574521003239 substrate binding site [polypeptide binding]; other site 574521003240 dimer interface [polypeptide binding]; other site 574521003241 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 574521003242 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 574521003243 catalytic core [active] 574521003244 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 574521003245 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521003246 hypothetical protein; Provisional; Region: PRK10174 574521003247 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 574521003248 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 574521003249 General stress protein [General function prediction only]; Region: GsiB; COG3729 574521003250 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 574521003251 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 574521003252 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 574521003253 putative FMN binding site [chemical binding]; other site 574521003254 pyrimidine utilization protein D; Region: RutD; TIGR03611 574521003255 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 574521003256 homotrimer interaction site [polypeptide binding]; other site 574521003257 putative active site [active] 574521003258 Isochorismatase family; Region: Isochorismatase; pfam00857 574521003259 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 574521003260 catalytic triad [active] 574521003261 conserved cis-peptide bond; other site 574521003262 pyrimidine utilization protein A; Region: RutA; TIGR03612 574521003263 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 574521003264 active site 574521003265 dimer interface [polypeptide binding]; other site 574521003266 non-prolyl cis peptide bond; other site 574521003267 insertion regions; other site 574521003268 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 574521003269 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 574521003270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521003271 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 574521003272 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 574521003273 Predicted transcriptional regulator [Transcription]; Region: COG3905 574521003274 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 574521003275 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 574521003276 Glutamate binding site [chemical binding]; other site 574521003277 NAD binding site [chemical binding]; other site 574521003278 catalytic residues [active] 574521003279 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 574521003280 Na binding site [ion binding]; other site 574521003281 FTR1 family protein; Region: TIGR00145 574521003282 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 574521003283 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 574521003284 Imelysin; Region: Peptidase_M75; pfam09375 574521003285 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 574521003286 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 574521003287 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 574521003288 hypothetical protein; Provisional; Region: PRK10536 574521003289 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 574521003290 integrative element E2348_IE2 574521003291 integrase; Provisional; Region: PRK09692 574521003292 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 574521003293 active site 574521003294 Int/Topo IB signature motif; other site 574521003295 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 574521003296 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 574521003297 pseudogene, C-ter part of transposase Orf2 of IS600 574521003298 E2348_IE2; pseudogene, N-ter part of conserved protein 574521003299 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 574521003300 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 574521003301 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 574521003302 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 574521003303 E2348_IE2; pseudogene, T3SS secreted effector NleB homolog, truncated by frameshift mutation 574521003304 E2348_IE2; pseudogene, T3SS secreted effector EspL homolog, truncated by frameshift mutation and deletion 574521003305 E2348_IE2; pseudogene, C-ter part of transposase of IS608 574521003306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 574521003307 Transposase; Region: DEDD_Tnp_IS110; pfam01548 574521003308 Transposase; Region: HTH_Tnp_1; cl17663 574521003309 putative transposase OrfB; Reviewed; Region: PHA02517 574521003310 HTH-like domain; Region: HTH_21; pfam13276 574521003311 Integrase core domain; Region: rve; pfam00665 574521003312 Integrase core domain; Region: rve_3; pfam13683 574521003313 E2348_IE2; pseudogene, transposase of IS4 family IS element (IS186B-like), N-ter and C-ter truncated 574521003314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 574521003315 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 574521003316 DNA-binding interface [nucleotide binding]; DNA binding site 574521003317 Integrase core domain; Region: rve; pfam00665 574521003318 transposase/IS protein; Provisional; Region: PRK09183 574521003319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521003320 Walker A motif; other site 574521003321 ATP binding site [chemical binding]; other site 574521003322 Walker B motif; other site 574521003323 Protein of unknown function DUF45; Region: DUF45; pfam01863 574521003324 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 574521003325 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 574521003326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 574521003327 ATP binding site [chemical binding]; other site 574521003328 putative Mg++ binding site [ion binding]; other site 574521003329 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 574521003330 ADP-ribose binding site [chemical binding]; other site 574521003331 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 574521003332 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 574521003333 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 574521003334 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 574521003335 HsdM N-terminal domain; Region: HsdM_N; pfam12161 574521003336 Methyltransferase domain; Region: Methyltransf_26; pfam13659 574521003337 putative transposase OrfB; Reviewed; Region: PHA02517 574521003338 HTH-like domain; Region: HTH_21; pfam13276 574521003339 Integrase core domain; Region: rve; pfam00665 574521003340 Integrase core domain; Region: rve_2; pfam13333 574521003341 Transposase; Region: HTH_Tnp_1; cl17663 574521003342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 574521003343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 574521003344 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 574521003345 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 574521003346 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 574521003347 E2348_IE2; pseudogene, transposase of IS30, truncated at C-ter part and truncated by frameshift mutation 574521003348 putative transposase OrfB; Reviewed; Region: PHA02517 574521003349 HTH-like domain; Region: HTH_21; pfam13276 574521003350 Integrase core domain; Region: rve; pfam00665 574521003351 Integrase core domain; Region: rve_3; pfam13683 574521003352 Transposase; Region: HTH_Tnp_1; cl17663 574521003353 E2348_IE2; pseudogene, N-ter part of transposase Orf1 of IS911 574521003354 E2348_IE2; pseudogene, conserved protein, truncated by frameshift mutation 574521003355 E2348_IE2; pseudogene, AidA-I adhesin-like protein, middle part only 574521003356 hypothetical protein; Provisional; Region: PRK09866 574521003357 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 574521003358 G1 box; other site 574521003359 GTP/Mg2+ binding site [chemical binding]; other site 574521003360 G2 box; other site 574521003361 Switch I region; other site 574521003362 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 574521003363 G3 box; other site 574521003364 Switch II region; other site 574521003365 GTP/Mg2+ binding site [chemical binding]; other site 574521003366 G4 box; other site 574521003367 G5 box; other site 574521003368 YjcZ-like protein; Region: YjcZ; pfam13990 574521003369 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 574521003370 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 574521003371 nucleophile elbow; other site 574521003372 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 574521003373 Domain of unknown function (DUF932); Region: DUF932; pfam06067 574521003374 Antirestriction protein; Region: Antirestrict; pfam03230 574521003375 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 574521003376 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 574521003377 MPN+ (JAMM) motif; other site 574521003378 Zinc-binding site [ion binding]; other site 574521003379 Protein of unknown function (DUF987); Region: DUF987; pfam06174 574521003380 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 574521003381 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 574521003382 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 574521003383 Methyltransferase domain; Region: Methyltransf_27; pfam13708 574521003384 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 574521003385 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 574521003386 putative ligand binding site [chemical binding]; other site 574521003387 NAD binding site [chemical binding]; other site 574521003388 dimerization interface [polypeptide binding]; other site 574521003389 catalytic site [active] 574521003390 putative hydrolase; Validated; Region: PRK09248 574521003391 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 574521003392 active site 574521003393 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 574521003394 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 574521003395 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 574521003396 curli assembly protein CsgF; Provisional; Region: PRK10050 574521003397 curli assembly protein CsgE; Provisional; Region: PRK10386 574521003398 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 574521003399 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521003400 DNA binding residues [nucleotide binding] 574521003401 dimerization interface [polypeptide binding]; other site 574521003402 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 574521003403 Curlin associated repeat; Region: Curlin_rpt; pfam07012 574521003404 Curlin associated repeat; Region: Curlin_rpt; pfam07012 574521003405 major curlin subunit; Provisional; Region: csgA; PRK10051 574521003406 Curlin associated repeat; Region: Curlin_rpt; pfam07012 574521003407 Curlin associated repeat; Region: Curlin_rpt; pfam07012 574521003408 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 574521003409 Fimbrial protein; Region: Fimbrial; cl01416 574521003410 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 574521003411 putative ADP-ribose binding site [chemical binding]; other site 574521003412 putative active site [active] 574521003413 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 574521003414 PLD-like domain; Region: PLDc_2; pfam13091 574521003415 putative active site [active] 574521003416 catalytic site [active] 574521003417 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 574521003418 PLD-like domain; Region: PLDc_2; pfam13091 574521003419 putative active site [active] 574521003420 catalytic site [active] 574521003421 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 574521003422 Acyltransferase family; Region: Acyl_transf_3; pfam01757 574521003423 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 574521003424 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 574521003425 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 574521003426 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 574521003427 Ligand binding site; other site 574521003428 DXD motif; other site 574521003429 lipoprotein; Provisional; Region: PRK10175 574521003430 secY/secA suppressor protein; Provisional; Region: PRK11467 574521003431 drug efflux system protein MdtG; Provisional; Region: PRK09874 574521003432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521003433 putative substrate translocation pore; other site 574521003434 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 574521003435 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 574521003436 putative acyl-acceptor binding pocket; other site 574521003437 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 574521003438 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 574521003439 active site residue [active] 574521003440 hypothetical protein; Provisional; Region: PRK03757 574521003441 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 574521003442 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 574521003443 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 574521003444 hydroxyglutarate oxidase; Provisional; Region: PRK11728 574521003445 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 574521003446 DNA damage-inducible protein I; Provisional; Region: PRK10597 574521003447 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 574521003448 active site 574521003449 substrate binding pocket [chemical binding]; other site 574521003450 dimer interface [polypeptide binding]; other site 574521003451 lipoprotein; Provisional; Region: PRK10598 574521003452 glutaredoxin 2; Provisional; Region: PRK10387 574521003453 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 574521003454 C-terminal domain interface [polypeptide binding]; other site 574521003455 GSH binding site (G-site) [chemical binding]; other site 574521003456 catalytic residues [active] 574521003457 putative dimer interface [polypeptide binding]; other site 574521003458 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 574521003459 N-terminal domain interface [polypeptide binding]; other site 574521003460 multidrug resistance protein MdtH; Provisional; Region: PRK11646 574521003461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521003462 putative substrate translocation pore; other site 574521003463 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 574521003464 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 574521003465 hypothetical protein; Provisional; Region: PRK11239 574521003466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 574521003467 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 574521003468 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 574521003469 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 574521003470 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 574521003471 MviN-like protein; Region: MVIN; pfam03023 574521003472 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 574521003473 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 574521003474 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 574521003475 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 574521003476 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 574521003477 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 574521003478 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 574521003479 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 574521003480 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 574521003481 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 574521003482 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 574521003483 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 574521003484 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 574521003485 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 574521003486 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 574521003487 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 574521003488 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 574521003489 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 574521003490 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 574521003491 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 574521003492 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 574521003493 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 574521003494 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 574521003495 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 574521003496 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 574521003497 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 574521003498 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 574521003499 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 574521003500 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 574521003501 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 574521003502 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 574521003503 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 574521003504 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 574521003505 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 574521003506 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 574521003507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521003508 Coenzyme A binding pocket [chemical binding]; other site 574521003509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 574521003510 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 574521003511 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 574521003512 homodimer interface [polypeptide binding]; other site 574521003513 oligonucleotide binding site [chemical binding]; other site 574521003514 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 574521003515 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 574521003516 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 574521003517 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 574521003518 RNA binding surface [nucleotide binding]; other site 574521003519 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 574521003520 active site 574521003521 Maf-like protein; Region: Maf; pfam02545 574521003522 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 574521003523 active site 574521003524 dimer interface [polypeptide binding]; other site 574521003525 hypothetical protein; Provisional; Region: PRK11193 574521003526 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 574521003527 putative phosphate acyltransferase; Provisional; Region: PRK05331 574521003528 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 574521003529 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 574521003530 dimer interface [polypeptide binding]; other site 574521003531 active site 574521003532 CoA binding pocket [chemical binding]; other site 574521003533 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 574521003534 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 574521003535 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 574521003536 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 574521003537 NAD(P) binding site [chemical binding]; other site 574521003538 homotetramer interface [polypeptide binding]; other site 574521003539 homodimer interface [polypeptide binding]; other site 574521003540 active site 574521003541 acyl carrier protein; Provisional; Region: acpP; PRK00982 574521003542 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 574521003543 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 574521003544 dimer interface [polypeptide binding]; other site 574521003545 active site 574521003546 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 574521003547 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 574521003548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521003549 catalytic residue [active] 574521003550 conserved hypothetical protein, YceG family; Region: TIGR00247 574521003551 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 574521003552 dimerization interface [polypeptide binding]; other site 574521003553 thymidylate kinase; Validated; Region: tmk; PRK00698 574521003554 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 574521003555 TMP-binding site; other site 574521003556 ATP-binding site [chemical binding]; other site 574521003557 DNA polymerase III subunit delta'; Validated; Region: PRK07993 574521003558 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 574521003559 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 574521003560 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 574521003561 active site 574521003562 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 574521003563 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 574521003564 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 574521003565 active site turn [active] 574521003566 phosphorylation site [posttranslational modification] 574521003567 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 574521003568 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 574521003569 N-terminal plug; other site 574521003570 ligand-binding site [chemical binding]; other site 574521003571 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 574521003572 nucleotide binding site/active site [active] 574521003573 HIT family signature motif; other site 574521003574 catalytic residue [active] 574521003575 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 574521003576 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 574521003577 putative dimer interface [polypeptide binding]; other site 574521003578 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 574521003579 thiamine kinase; Region: ycfN_thiK; TIGR02721 574521003580 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 574521003581 active site 574521003582 substrate binding site [chemical binding]; other site 574521003583 ATP binding site [chemical binding]; other site 574521003584 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 574521003585 beta-hexosaminidase; Provisional; Region: PRK05337 574521003586 hypothetical protein; Provisional; Region: PRK04940 574521003587 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 574521003588 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521003589 hypothetical protein; Provisional; Region: PRK11280 574521003590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 574521003591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521003592 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 574521003593 L,D-transpeptidase; Provisional; Region: PRK10260 574521003594 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 574521003595 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 574521003596 transcription-repair coupling factor; Provisional; Region: PRK10689 574521003597 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 574521003598 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 574521003599 ATP binding site [chemical binding]; other site 574521003600 putative Mg++ binding site [ion binding]; other site 574521003601 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521003602 nucleotide binding region [chemical binding]; other site 574521003603 ATP-binding site [chemical binding]; other site 574521003604 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 574521003605 Predicted membrane protein [Function unknown]; Region: COG4763 574521003606 Acyltransferase family; Region: Acyl_transf_3; pfam01757 574521003607 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 574521003608 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 574521003609 FtsX-like permease family; Region: FtsX; pfam02687 574521003610 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 574521003611 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 574521003612 Walker A/P-loop; other site 574521003613 ATP binding site [chemical binding]; other site 574521003614 Q-loop/lid; other site 574521003615 ABC transporter signature motif; other site 574521003616 Walker B; other site 574521003617 D-loop; other site 574521003618 H-loop/switch region; other site 574521003619 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 574521003620 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 574521003621 FtsX-like permease family; Region: FtsX; pfam02687 574521003622 fructokinase; Reviewed; Region: PRK09557 574521003623 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 574521003624 nucleotide binding site [chemical binding]; other site 574521003625 NAD-dependent deacetylase; Provisional; Region: PRK00481 574521003626 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 574521003627 NAD+ binding site [chemical binding]; other site 574521003628 substrate binding site [chemical binding]; other site 574521003629 Zn binding site [ion binding]; other site 574521003630 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 574521003631 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 574521003632 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 574521003633 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 574521003634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521003635 dimer interface [polypeptide binding]; other site 574521003636 conserved gate region; other site 574521003637 putative PBP binding loops; other site 574521003638 ABC-ATPase subunit interface; other site 574521003639 prophage E2348_PP5, lambdoid 574521003640 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 574521003641 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 574521003642 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 574521003643 dimer interface [polypeptide binding]; other site 574521003644 active site 574521003645 Int/Topo IB signature motif; other site 574521003646 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 574521003647 active site 574521003648 catalytic site [active] 574521003649 substrate binding site [chemical binding]; other site 574521003650 E2348_PP5; pseudogene, conserved protein, truncated by premature stop codon 574521003651 DicB protein; Region: DicB; pfam05358 574521003652 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 574521003653 transcriptional repressor DicA; Reviewed; Region: PRK09706 574521003654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521003655 non-specific DNA binding site [nucleotide binding]; other site 574521003656 salt bridge; other site 574521003657 sequence-specific DNA binding site [nucleotide binding]; other site 574521003658 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 574521003659 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 574521003660 Pyocin large subunit [General function prediction only]; Region: COG5529 574521003661 Helix-turn-helix domain; Region: HTH_36; pfam13730 574521003662 primosomal protein DnaI; Provisional; Region: PRK02854 574521003663 E2348_PP5; pseudogene, recombinase, fragmented by premature stop codon and frameshift mutation 574521003664 AAA domain; Region: AAA_21; pfam13304 574521003665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521003666 Q-loop/lid; other site 574521003667 ABC transporter signature motif; other site 574521003668 Walker B; other site 574521003669 D-loop; other site 574521003670 H-loop/switch region; other site 574521003671 TIGR02646 family protein; Region: TIGR02646 574521003672 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521003673 Homeodomain-like domain; Region: HTH_32; pfam13565 574521003674 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 574521003675 Integrase core domain; Region: rve; pfam00665 574521003676 Integrase core domain; Region: rve_3; pfam13683 574521003677 E2348_PP5; pseudogene, host cell killing protein, paerial 574521003678 Protein of unknown function (DUF968); Region: DUF968; pfam06147 574521003679 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 574521003680 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 574521003681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521003682 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 574521003683 DNA methylase; Region: N6_N4_Mtase; pfam01555 574521003684 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 574521003685 anti-adapter protein IraM; Provisional; Region: PRK09919 574521003686 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 574521003687 Domain of unknown function (DUF303); Region: DUF303; pfam03629 574521003688 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521003689 Transposase IS200 like; Region: Y1_Tnp; pfam01797 574521003690 Lysis protein S; Region: Lysis_S; pfam04971 574521003691 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 574521003692 catalytic residues [active] 574521003693 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 574521003694 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 574521003695 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 574521003696 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 574521003697 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 574521003698 gpW; Region: gpW; pfam02831 574521003699 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 574521003700 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 574521003701 E2348_PP5; pseudogene, N-ter part of capsid assembly protein 574521003702 Phage-related protein, tail component [Function unknown]; Region: COG4723 574521003703 Phage-related protein, tail component [Function unknown]; Region: COG4733 574521003704 Putative phage tail protein; Region: Phage-tail_3; pfam13550 574521003705 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 574521003706 Fibronectin type III protein; Region: DUF3672; pfam12421 574521003707 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 574521003708 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 574521003709 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 574521003710 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 574521003711 E2348_PP5; pseudogene, C-ter part of transposase Orf2 of IS2 574521003712 E2348_PP5; pseudogene, tail fiber assembly protein, N-ter part missing 574521003713 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 574521003714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521003715 dimer interface [polypeptide binding]; other site 574521003716 conserved gate region; other site 574521003717 putative PBP binding loops; other site 574521003718 ABC-ATPase subunit interface; other site 574521003719 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 574521003720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521003721 Walker A/P-loop; other site 574521003722 ATP binding site [chemical binding]; other site 574521003723 Q-loop/lid; other site 574521003724 ABC transporter signature motif; other site 574521003725 Walker B; other site 574521003726 D-loop; other site 574521003727 H-loop/switch region; other site 574521003728 TOBE domain; Region: TOBE_2; pfam08402 574521003729 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 574521003730 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 574521003731 metal binding site [ion binding]; metal-binding site 574521003732 dimer interface [polypeptide binding]; other site 574521003733 Uncharacterized conserved protein [Function unknown]; Region: COG2850 574521003734 Cupin-like domain; Region: Cupin_8; pfam13621 574521003735 sensor protein PhoQ; Provisional; Region: PRK10815 574521003736 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 574521003737 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 574521003738 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 574521003739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521003740 ATP binding site [chemical binding]; other site 574521003741 Mg2+ binding site [ion binding]; other site 574521003742 G-X-G motif; other site 574521003743 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 574521003744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521003745 active site 574521003746 phosphorylation site [posttranslational modification] 574521003747 intermolecular recognition site; other site 574521003748 dimerization interface [polypeptide binding]; other site 574521003749 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521003750 DNA binding site [nucleotide binding] 574521003751 adenylosuccinate lyase; Provisional; Region: PRK09285 574521003752 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 574521003753 tetramer interface [polypeptide binding]; other site 574521003754 active site 574521003755 putative lysogenization regulator; Reviewed; Region: PRK00218 574521003756 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 574521003757 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 574521003758 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 574521003759 nudix motif; other site 574521003760 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 574521003761 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 574521003762 probable active site [active] 574521003763 isocitrate dehydrogenase; Validated; Region: PRK07362 574521003764 isocitrate dehydrogenase; Reviewed; Region: PRK07006 574521003765 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 574521003766 transcriptional regulator MirA; Provisional; Region: PRK15043 574521003767 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 574521003768 DNA binding residues [nucleotide binding] 574521003769 Sensors of blue-light using FAD; Region: BLUF; smart01034 574521003770 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521003771 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 574521003772 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 574521003773 pseudogene, C-ter part of conserved inner membrane protein 574521003774 pseudogene, conserved protein, truncated by frameshift mutation 574521003775 pseudogene, C-ter part of ATP-binding component of a transport system 574521003776 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 574521003777 cell division inhibitor MinD; Provisional; Region: PRK10818 574521003778 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 574521003779 Switch I; other site 574521003780 Switch II; other site 574521003781 septum formation inhibitor; Reviewed; Region: minC; PRK03511 574521003782 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 574521003783 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 574521003784 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 574521003785 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 574521003786 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 574521003787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 574521003788 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 574521003789 hypothetical protein; Provisional; Region: PRK10691 574521003790 hypothetical protein; Provisional; Region: PRK05170 574521003791 pseudogene, C-ter part of hemolysin E 574521003792 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 574521003793 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 574521003794 Catalytic site [active] 574521003795 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 574521003796 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 574521003797 active site 574521003798 DNA binding site [nucleotide binding] 574521003799 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 574521003800 disulfide bond formation protein B; Provisional; Region: PRK01749 574521003801 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 574521003802 transmembrane helices; other site 574521003803 fatty acid metabolism regulator; Provisional; Region: PRK04984 574521003804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521003805 DNA-binding site [nucleotide binding]; DNA binding site 574521003806 FadR C-terminal domain; Region: FadR_C; pfam07840 574521003807 SpoVR family protein; Provisional; Region: PRK11767 574521003808 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 574521003809 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 574521003810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521003811 alanine racemase; Reviewed; Region: dadX; PRK03646 574521003812 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 574521003813 active site 574521003814 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 574521003815 substrate binding site [chemical binding]; other site 574521003816 catalytic residues [active] 574521003817 dimer interface [polypeptide binding]; other site 574521003818 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 574521003819 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 574521003820 TrkA-C domain; Region: TrkA_C; pfam02080 574521003821 Transporter associated domain; Region: CorC_HlyC; smart01091 574521003822 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 574521003823 dimer interface [polypeptide binding]; other site 574521003824 catalytic triad [active] 574521003825 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 574521003826 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 574521003827 N-acetyl-D-glucosamine binding site [chemical binding]; other site 574521003828 catalytic residue [active] 574521003829 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 574521003830 Flagellar regulator YcgR; Region: YcgR; pfam07317 574521003831 PilZ domain; Region: PilZ; pfam07238 574521003832 hypothetical protein; Provisional; Region: PRK10457 574521003833 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 574521003834 N-terminal plug; other site 574521003835 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 574521003836 ligand-binding site [chemical binding]; other site 574521003837 molybdenum transport protein ModD; Provisional; Region: PRK06096 574521003838 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 574521003839 dimerization interface [polypeptide binding]; other site 574521003840 active site 574521003841 Methyltransferase domain; Region: Methyltransf_31; pfam13847 574521003842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521003843 S-adenosylmethionine binding site [chemical binding]; other site 574521003844 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 574521003845 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 574521003846 Walker A/P-loop; other site 574521003847 ATP binding site [chemical binding]; other site 574521003848 Q-loop/lid; other site 574521003849 ABC transporter signature motif; other site 574521003850 Walker B; other site 574521003851 D-loop; other site 574521003852 H-loop/switch region; other site 574521003853 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 574521003854 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 574521003855 ABC-ATPase subunit interface; other site 574521003856 dimer interface [polypeptide binding]; other site 574521003857 putative PBP binding regions; other site 574521003858 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 574521003859 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 574521003860 putative metal binding site [ion binding]; other site 574521003861 trehalase; Provisional; Region: treA; PRK13271 574521003862 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 574521003863 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 574521003864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 574521003865 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 574521003866 dimerization domain swap beta strand [polypeptide binding]; other site 574521003867 regulatory protein interface [polypeptide binding]; other site 574521003868 active site 574521003869 regulatory phosphorylation site [posttranslational modification]; other site 574521003870 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 574521003871 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 574521003872 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 574521003873 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 574521003874 Dak1 domain; Region: Dak1; pfam02733 574521003875 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 574521003876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 574521003877 putative active site [active] 574521003878 heme pocket [chemical binding]; other site 574521003879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521003880 Walker A motif; other site 574521003881 ATP binding site [chemical binding]; other site 574521003882 Walker B motif; other site 574521003883 arginine finger; other site 574521003884 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 574521003885 GTP-binding protein YchF; Reviewed; Region: PRK09601 574521003886 YchF GTPase; Region: YchF; cd01900 574521003887 G1 box; other site 574521003888 GTP/Mg2+ binding site [chemical binding]; other site 574521003889 Switch I region; other site 574521003890 G2 box; other site 574521003891 Switch II region; other site 574521003892 G3 box; other site 574521003893 G4 box; other site 574521003894 G5 box; other site 574521003895 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 574521003896 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 574521003897 putative active site [active] 574521003898 catalytic residue [active] 574521003899 hypothetical protein; Provisional; Region: PRK10692 574521003900 putative transporter; Provisional; Region: PRK11660 574521003901 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 574521003902 Sulfate transporter family; Region: Sulfate_transp; pfam00916 574521003903 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 574521003904 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 574521003905 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 574521003906 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 574521003907 active site 574521003908 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 574521003909 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 574521003910 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 574521003911 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 574521003912 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 574521003913 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 574521003914 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 574521003915 tRNA; other site 574521003916 putative tRNA binding site [nucleotide binding]; other site 574521003917 putative NADP binding site [chemical binding]; other site 574521003918 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 574521003919 peptide chain release factor 1; Validated; Region: prfA; PRK00591 574521003920 This domain is found in peptide chain release factors; Region: PCRF; smart00937 574521003921 RF-1 domain; Region: RF-1; pfam00472 574521003922 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 574521003923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521003924 hypothetical protein; Provisional; Region: PRK10278 574521003925 hypothetical protein; Provisional; Region: PRK10941 574521003926 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 574521003927 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 574521003928 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 574521003929 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 574521003930 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 574521003931 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 574521003932 cation transport regulator; Reviewed; Region: chaB; PRK09582 574521003933 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 574521003934 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 574521003935 putative active site pocket [active] 574521003936 dimerization interface [polypeptide binding]; other site 574521003937 putative catalytic residue [active] 574521003938 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 574521003939 putative invasin; Provisional; Region: PRK10177 574521003940 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 574521003941 transcriptional regulator NarL; Provisional; Region: PRK10651 574521003942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521003943 active site 574521003944 phosphorylation site [posttranslational modification] 574521003945 intermolecular recognition site; other site 574521003946 dimerization interface [polypeptide binding]; other site 574521003947 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521003948 DNA binding residues [nucleotide binding] 574521003949 dimerization interface [polypeptide binding]; other site 574521003950 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 574521003951 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 574521003952 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 574521003953 dimerization interface [polypeptide binding]; other site 574521003954 Histidine kinase; Region: HisKA_3; pfam07730 574521003955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521003956 ATP binding site [chemical binding]; other site 574521003957 Mg2+ binding site [ion binding]; other site 574521003958 G-X-G motif; other site 574521003959 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 574521003960 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 574521003961 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 574521003962 [4Fe-4S] binding site [ion binding]; other site 574521003963 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 574521003964 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 574521003965 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 574521003966 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 574521003967 molybdopterin cofactor binding site; other site 574521003968 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 574521003969 4Fe-4S binding domain; Region: Fer4; cl02805 574521003970 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 574521003971 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 574521003972 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 574521003973 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 574521003974 dimer interface [polypeptide binding]; other site 574521003975 active site 574521003976 CoA binding pocket [chemical binding]; other site 574521003977 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 574521003978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 574521003979 NAD(P) binding site [chemical binding]; other site 574521003980 active site 574521003981 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 574521003982 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 574521003983 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 574521003984 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 574521003985 active site 574521003986 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 574521003987 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 574521003988 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 574521003989 putative di-iron ligands [ion binding]; other site 574521003990 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 574521003991 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 574521003992 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 574521003993 putative active site [active] 574521003994 putative substrate binding site [chemical binding]; other site 574521003995 putative cosubstrate binding site; other site 574521003996 catalytic site [active] 574521003997 SEC-C motif; Region: SEC-C; pfam02810 574521003998 hypothetical protein; Provisional; Region: PRK04233 574521003999 hypothetical protein; Provisional; Region: PRK10279 574521004000 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 574521004001 active site 574521004002 nucleophile elbow; other site 574521004003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521004004 active site 574521004005 response regulator of RpoS; Provisional; Region: PRK10693 574521004006 phosphorylation site [posttranslational modification] 574521004007 intermolecular recognition site; other site 574521004008 dimerization interface [polypeptide binding]; other site 574521004009 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 574521004010 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 574521004011 active site 574521004012 tetramer interface; other site 574521004013 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 574521004014 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 574521004015 thymidine kinase; Provisional; Region: PRK04296 574521004016 pseudogene, N-ter part of transposase of IS4, contains a frameshift mutation 574521004017 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 574521004018 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 574521004019 putative catalytic cysteine [active] 574521004020 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 574521004021 putative active site [active] 574521004022 metal binding site [ion binding]; metal-binding site 574521004023 hypothetical protein; Provisional; Region: PRK11111 574521004024 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 574521004025 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 574521004026 peptide binding site [polypeptide binding]; other site 574521004027 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 574521004028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521004029 dimer interface [polypeptide binding]; other site 574521004030 conserved gate region; other site 574521004031 putative PBP binding loops; other site 574521004032 ABC-ATPase subunit interface; other site 574521004033 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 574521004034 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 574521004035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521004036 dimer interface [polypeptide binding]; other site 574521004037 conserved gate region; other site 574521004038 putative PBP binding loops; other site 574521004039 ABC-ATPase subunit interface; other site 574521004040 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 574521004041 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521004042 Walker A/P-loop; other site 574521004043 ATP binding site [chemical binding]; other site 574521004044 Q-loop/lid; other site 574521004045 ABC transporter signature motif; other site 574521004046 Walker B; other site 574521004047 D-loop; other site 574521004048 H-loop/switch region; other site 574521004049 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 574521004050 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 574521004051 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521004052 Walker A/P-loop; other site 574521004053 ATP binding site [chemical binding]; other site 574521004054 Q-loop/lid; other site 574521004055 ABC transporter signature motif; other site 574521004056 Walker B; other site 574521004057 D-loop; other site 574521004058 H-loop/switch region; other site 574521004059 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 574521004060 dsDNA-mimic protein; Reviewed; Region: PRK05094 574521004061 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 574521004062 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 574521004063 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 574521004064 putative active site [active] 574521004065 catalytic site [active] 574521004066 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 574521004067 putative active site [active] 574521004068 catalytic site [active] 574521004069 voltage-gated potassium channel; Provisional; Region: PRK10537 574521004070 Ion channel; Region: Ion_trans_2; pfam07885 574521004071 TrkA-N domain; Region: TrkA_N; pfam02254 574521004072 YciI-like protein; Reviewed; Region: PRK11370 574521004073 transport protein TonB; Provisional; Region: PRK10819 574521004074 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 574521004075 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 574521004076 intracellular septation protein A; Reviewed; Region: PRK00259 574521004077 hypothetical protein; Provisional; Region: PRK02868 574521004078 outer membrane protein W; Provisional; Region: PRK10959 574521004079 prophage E2348_PP6, lambdoid 574521004080 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 574521004081 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 574521004082 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 574521004083 dimer interface [polypeptide binding]; other site 574521004084 active site 574521004085 Int/Topo IB signature motif; other site 574521004086 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 574521004087 active site 574521004088 catalytic site [active] 574521004089 substrate binding site [chemical binding]; other site 574521004090 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 574521004091 DicB protein; Region: DicB; pfam05358 574521004092 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 574521004093 transcriptional repressor DicA; Reviewed; Region: PRK09706 574521004094 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 574521004095 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 574521004096 Helix-turn-helix domain; Region: HTH_36; pfam13730 574521004097 primosomal protein DnaI; Provisional; Region: PRK02854 574521004098 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 574521004099 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 574521004100 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 574521004101 Hok/gef family; Region: HOK_GEF; pfam01848 574521004102 Hok/gef family; Region: HOK_GEF; pfam01848 574521004103 Protein of unknown function (DUF968); Region: DUF968; pfam06147 574521004104 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 574521004105 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 574521004106 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521004107 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 574521004108 Domain of unknown function (DUF303); Region: DUF303; pfam03629 574521004109 Lysis protein S; Region: Lysis_S; pfam04971 574521004110 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 574521004111 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 574521004112 catalytic residues [active] 574521004113 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 574521004114 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 574521004115 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 574521004116 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 574521004117 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 574521004118 active site 574521004119 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 574521004120 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 574521004121 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 574521004122 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 574521004123 Phage capsid family; Region: Phage_capsid; pfam05065 574521004124 Phage-related protein [Function unknown]; Region: COG4695 574521004125 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 574521004126 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 574521004127 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 574521004128 zinc binding site [ion binding]; other site 574521004129 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 574521004130 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 574521004131 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 574521004132 Immunoglobulin domain; Region: Ig_3; pfam13927 574521004133 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 574521004134 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 574521004135 Phage-related minor tail protein [Function unknown]; Region: COG5281 574521004136 tape measure domain; Region: tape_meas_nterm; TIGR02675 574521004137 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 574521004138 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 574521004139 Phage-related protein [Function unknown]; Region: COG4718 574521004140 Phage-related protein [Function unknown]; Region: gp18; COG4672 574521004141 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 574521004142 MPN+ (JAMM) motif; other site 574521004143 Zinc-binding site [ion binding]; other site 574521004144 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 574521004145 NlpC/P60 family; Region: NLPC_P60; cl17555 574521004146 Phage-related protein, tail component [Function unknown]; Region: COG4723 574521004147 Phage-related protein, tail component [Function unknown]; Region: COG4733 574521004148 Putative phage tail protein; Region: Phage-tail_3; pfam13550 574521004149 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 574521004150 Interdomain contacts; other site 574521004151 Cytokine receptor motif; other site 574521004152 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 574521004153 Fibronectin type III protein; Region: DUF3672; pfam12421 574521004154 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 574521004155 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 574521004156 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 574521004157 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 574521004158 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 574521004159 E2348_PP6; pseudogene, integrase, partial 574521004160 hypothetical protein; Provisional; Region: PHA03031 574521004161 E2348_PP6; pseudogene, C-ter part of transposase of IS256 family IS element, contains a frameshift mutation 574521004162 E2348_PP6; pseudogene, C-ter part of T3SS effector-like protein EspO homolog 574521004163 Transposase IS200 like; Region: Y1_Tnp; pfam01797 574521004164 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521004165 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 574521004166 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 574521004167 substrate binding site [chemical binding]; other site 574521004168 active site 574521004169 catalytic residues [active] 574521004170 heterodimer interface [polypeptide binding]; other site 574521004171 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 574521004172 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 574521004173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521004174 catalytic residue [active] 574521004175 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 574521004176 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 574521004177 active site 574521004178 ribulose/triose binding site [chemical binding]; other site 574521004179 phosphate binding site [ion binding]; other site 574521004180 substrate (anthranilate) binding pocket [chemical binding]; other site 574521004181 product (indole) binding pocket [chemical binding]; other site 574521004182 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 574521004183 active site 574521004184 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 574521004185 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 574521004186 glutamine binding [chemical binding]; other site 574521004187 catalytic triad [active] 574521004188 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 574521004189 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 574521004190 anthranilate synthase component I; Provisional; Region: PRK13564 574521004191 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 574521004192 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 574521004193 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 574521004194 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 574521004195 active site 574521004196 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 574521004197 hypothetical protein; Provisional; Region: PRK11630 574521004198 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 574521004199 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 574521004200 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 574521004201 RNA binding surface [nucleotide binding]; other site 574521004202 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 574521004203 probable active site [active] 574521004204 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 574521004205 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 574521004206 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 574521004207 homodimer interface [polypeptide binding]; other site 574521004208 Walker A motif; other site 574521004209 ATP binding site [chemical binding]; other site 574521004210 hydroxycobalamin binding site [chemical binding]; other site 574521004211 Walker B motif; other site 574521004212 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 574521004213 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 574521004214 NADP binding site [chemical binding]; other site 574521004215 homodimer interface [polypeptide binding]; other site 574521004216 active site 574521004217 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 574521004218 putative inner membrane peptidase; Provisional; Region: PRK11778 574521004219 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 574521004220 tandem repeat interface [polypeptide binding]; other site 574521004221 oligomer interface [polypeptide binding]; other site 574521004222 active site residues [active] 574521004223 hypothetical protein; Provisional; Region: PRK11037 574521004224 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 574521004225 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 574521004226 active site 574521004227 interdomain interaction site; other site 574521004228 putative metal-binding site [ion binding]; other site 574521004229 nucleotide binding site [chemical binding]; other site 574521004230 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 574521004231 domain I; other site 574521004232 DNA binding groove [nucleotide binding] 574521004233 phosphate binding site [ion binding]; other site 574521004234 domain II; other site 574521004235 domain III; other site 574521004236 nucleotide binding site [chemical binding]; other site 574521004237 catalytic site [active] 574521004238 domain IV; other site 574521004239 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 574521004240 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 574521004241 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 574521004242 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 574521004243 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 574521004244 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521004245 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 574521004246 substrate binding site [chemical binding]; other site 574521004247 putative dimerization interface [polypeptide binding]; other site 574521004248 aconitate hydratase; Validated; Region: PRK09277 574521004249 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 574521004250 substrate binding site [chemical binding]; other site 574521004251 ligand binding site [chemical binding]; other site 574521004252 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 574521004253 substrate binding site [chemical binding]; other site 574521004254 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 574521004255 dimerization interface [polypeptide binding]; other site 574521004256 active site 574521004257 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 574521004258 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 574521004259 active site 574521004260 Predicted membrane protein [Function unknown]; Region: COG3771 574521004261 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 574521004262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 574521004263 TPR motif; other site 574521004264 binding surface 574521004265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 574521004266 binding surface 574521004267 TPR motif; other site 574521004268 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 574521004269 active site 574521004270 dimer interface [polypeptide binding]; other site 574521004271 translation initiation factor Sui1; Validated; Region: PRK06824 574521004272 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 574521004273 putative rRNA binding site [nucleotide binding]; other site 574521004274 lipoprotein; Provisional; Region: PRK10540 574521004275 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 574521004276 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 574521004277 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 574521004278 hypothetical protein; Provisional; Region: PRK13658 574521004279 RNase II stability modulator; Provisional; Region: PRK10060 574521004280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 574521004281 putative active site [active] 574521004282 heme pocket [chemical binding]; other site 574521004283 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 574521004284 metal binding site [ion binding]; metal-binding site 574521004285 active site 574521004286 I-site; other site 574521004287 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521004288 Transposase IS200 like; Region: Y1_Tnp; pfam01797 574521004289 exoribonuclease II; Provisional; Region: PRK05054 574521004290 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 574521004291 RNB domain; Region: RNB; pfam00773 574521004292 S1 RNA binding domain; Region: S1; pfam00575 574521004293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 574521004294 Uncharacterized conserved protein [Function unknown]; Region: COG2128 574521004295 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 574521004296 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 574521004297 NAD binding site [chemical binding]; other site 574521004298 homotetramer interface [polypeptide binding]; other site 574521004299 homodimer interface [polypeptide binding]; other site 574521004300 substrate binding site [chemical binding]; other site 574521004301 active site 574521004302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 574521004303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521004304 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 574521004305 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521004306 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521004307 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 574521004308 Protein export membrane protein; Region: SecD_SecF; cl14618 574521004309 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 574521004310 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 574521004311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521004312 putative substrate translocation pore; other site 574521004313 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521004314 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 574521004315 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521004316 Walker A/P-loop; other site 574521004317 ATP binding site [chemical binding]; other site 574521004318 Q-loop/lid; other site 574521004319 ABC transporter signature motif; other site 574521004320 Walker B; other site 574521004321 D-loop; other site 574521004322 H-loop/switch region; other site 574521004323 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 574521004324 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521004325 Walker A/P-loop; other site 574521004326 ATP binding site [chemical binding]; other site 574521004327 Q-loop/lid; other site 574521004328 ABC transporter signature motif; other site 574521004329 Walker B; other site 574521004330 D-loop; other site 574521004331 H-loop/switch region; other site 574521004332 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 574521004333 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 574521004334 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 574521004335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521004336 dimer interface [polypeptide binding]; other site 574521004337 conserved gate region; other site 574521004338 putative PBP binding loops; other site 574521004339 ABC-ATPase subunit interface; other site 574521004340 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 574521004341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521004342 dimer interface [polypeptide binding]; other site 574521004343 conserved gate region; other site 574521004344 putative PBP binding loops; other site 574521004345 ABC-ATPase subunit interface; other site 574521004346 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 574521004347 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 574521004348 peptide binding site [polypeptide binding]; other site 574521004349 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 574521004350 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 574521004351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521004352 Walker A motif; other site 574521004353 ATP binding site [chemical binding]; other site 574521004354 Walker B motif; other site 574521004355 arginine finger; other site 574521004356 phage shock protein PspA; Provisional; Region: PRK10698 574521004357 phage shock protein B; Provisional; Region: pspB; PRK09458 574521004358 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 574521004359 phage shock protein C; Region: phageshock_pspC; TIGR02978 574521004360 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 574521004361 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 574521004362 active site residue [active] 574521004363 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 574521004364 sucrose phosphorylase; Provisional; Region: PRK13840 574521004365 active site 574521004366 homodimer interface [polypeptide binding]; other site 574521004367 catalytic site [active] 574521004368 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 574521004369 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 574521004370 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 574521004371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521004372 dimer interface [polypeptide binding]; other site 574521004373 conserved gate region; other site 574521004374 putative PBP binding loops; other site 574521004375 ABC-ATPase subunit interface; other site 574521004376 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 574521004377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521004378 dimer interface [polypeptide binding]; other site 574521004379 conserved gate region; other site 574521004380 putative PBP binding loops; other site 574521004381 ABC-ATPase subunit interface; other site 574521004382 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 574521004383 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 574521004384 putative NAD(P) binding site [chemical binding]; other site 574521004385 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 574521004386 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 574521004387 Metal-binding active site; metal-binding site 574521004388 AP (apurinic/apyrimidinic) site pocket; other site 574521004389 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 574521004390 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 574521004391 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 574521004393 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521004394 beta-phosphoglucomutase; Region: bPGM; TIGR01990 574521004395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521004396 motif II; other site 574521004397 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 574521004398 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 574521004399 Walker A/P-loop; other site 574521004400 ATP binding site [chemical binding]; other site 574521004401 Q-loop/lid; other site 574521004402 ABC transporter signature motif; other site 574521004403 Walker B; other site 574521004404 D-loop; other site 574521004405 H-loop/switch region; other site 574521004406 TOBE domain; Region: TOBE_2; pfam08402 574521004407 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 574521004408 Transcriptional regulators [Transcription]; Region: PurR; COG1609 574521004409 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521004410 DNA binding site [nucleotide binding] 574521004411 domain linker motif; other site 574521004412 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 574521004413 putative dimerization interface [polypeptide binding]; other site 574521004414 putative ligand binding site [chemical binding]; other site 574521004415 Predicted ATPase [General function prediction only]; Region: COG3106 574521004416 hypothetical protein; Provisional; Region: PRK05415 574521004417 TIGR01620 family protein; Region: hyp_HI0043 574521004418 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 574521004419 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 574521004420 putative aromatic amino acid binding site; other site 574521004421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521004422 Walker A motif; other site 574521004423 ATP binding site [chemical binding]; other site 574521004424 Walker B motif; other site 574521004425 arginine finger; other site 574521004426 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 574521004427 dimer interface [polypeptide binding]; other site 574521004428 catalytic triad [active] 574521004429 peroxidatic and resolving cysteines [active] 574521004430 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 574521004431 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 574521004432 active site 574521004433 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 574521004434 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 574521004435 putative active site [active] 574521004436 Zn binding site [ion binding]; other site 574521004437 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 574521004438 NADH(P)-binding; Region: NAD_binding_10; pfam13460 574521004439 putative NAD(P) binding site [chemical binding]; other site 574521004440 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 574521004441 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 574521004442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 574521004443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521004444 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 574521004445 putative effector binding pocket; other site 574521004446 putative dimerization interface [polypeptide binding]; other site 574521004447 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 574521004448 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 574521004449 peptide binding site [polypeptide binding]; other site 574521004450 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 574521004451 Mechanosensitive ion channel; Region: MS_channel; pfam00924 574521004452 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 574521004453 universal stress protein UspE; Provisional; Region: PRK11175 574521004454 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 574521004455 Ligand Binding Site [chemical binding]; other site 574521004456 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 574521004457 Ligand Binding Site [chemical binding]; other site 574521004458 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 574521004459 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 574521004460 ligand binding site [chemical binding]; other site 574521004461 flexible hinge region; other site 574521004462 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 574521004463 putative switch regulator; other site 574521004464 non-specific DNA interactions [nucleotide binding]; other site 574521004465 DNA binding site [nucleotide binding] 574521004466 sequence specific DNA binding site [nucleotide binding]; other site 574521004467 putative cAMP binding site [chemical binding]; other site 574521004468 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 574521004469 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 574521004470 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 574521004471 DNA binding site [nucleotide binding] 574521004472 active site 574521004473 Cupin domain; Region: Cupin_2; cl17218 574521004474 Helix-turn-helix domain; Region: HTH_18; pfam12833 574521004475 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 574521004476 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521004477 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521004478 pseudogene, multidrug resistant protein, truncated by frameshift mutation 574521004479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 574521004480 Smr domain; Region: Smr; pfam01713 574521004481 pseudogene, diguanylate cyclase, GGDEF domain signalling protein, truncated by internal deletion 574521004482 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 574521004483 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 574521004484 Cl binding site [ion binding]; other site 574521004485 oligomer interface [polypeptide binding]; other site 574521004486 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 574521004487 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 574521004488 ATP binding site [chemical binding]; other site 574521004489 Mg++ binding site [ion binding]; other site 574521004490 motif III; other site 574521004491 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521004492 nucleotide binding region [chemical binding]; other site 574521004493 ATP-binding site [chemical binding]; other site 574521004494 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 574521004495 putative RNA binding site [nucleotide binding]; other site 574521004496 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 574521004497 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 574521004498 Ligand Binding Site [chemical binding]; other site 574521004499 remnant of Rac-like prophage 574521004500 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 574521004501 Ligand Binding Site [chemical binding]; other site 574521004502 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 574521004503 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 574521004504 trimer interface [polypeptide binding]; other site 574521004505 eyelet of channel; other site 574521004506 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 574521004507 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 574521004508 dimer interface [polypeptide binding]; other site 574521004509 PYR/PP interface [polypeptide binding]; other site 574521004510 TPP binding site [chemical binding]; other site 574521004511 substrate binding site [chemical binding]; other site 574521004512 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 574521004513 Domain of unknown function; Region: EKR; smart00890 574521004514 4Fe-4S binding domain; Region: Fer4_6; pfam12837 574521004515 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 574521004516 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 574521004517 TPP-binding site [chemical binding]; other site 574521004518 dimer interface [polypeptide binding]; other site 574521004519 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 574521004520 Domain of unknown function (DUF333); Region: DUF333; pfam03891 574521004521 heat-inducible protein; Provisional; Region: PRK10449 574521004522 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 574521004523 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 574521004524 putative ligand binding site [chemical binding]; other site 574521004525 putative NAD binding site [chemical binding]; other site 574521004526 catalytic site [active] 574521004527 hypothetical protein; Provisional; Region: PRK10695 574521004528 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 574521004529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 574521004530 pseudogene, C-ter part of DNA-binding transcriptional regulator 574521004531 note frameshift after codon 2; hexapeptide repeat acetyltransferase (pseudogene) 574521004532 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 574521004533 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 574521004534 active site 574521004535 catalytic tetrad [active] 574521004536 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521004537 azoreductase; Reviewed; Region: PRK00170 574521004538 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 574521004539 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 574521004540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 574521004541 ATP binding site [chemical binding]; other site 574521004542 putative Mg++ binding site [ion binding]; other site 574521004543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521004544 nucleotide binding region [chemical binding]; other site 574521004545 ATP-binding site [chemical binding]; other site 574521004546 Helicase associated domain (HA2); Region: HA2; pfam04408 574521004547 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 574521004548 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 574521004549 Uncharacterized conserved protein [Function unknown]; Region: COG1434 574521004550 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 574521004551 putative active site [active] 574521004552 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 574521004553 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 574521004554 NAD binding site [chemical binding]; other site 574521004555 catalytic residues [active] 574521004556 substrate binding site [chemical binding]; other site 574521004557 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 574521004558 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 574521004559 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 574521004560 cytochrome b561; Provisional; Region: PRK11513 574521004561 hypothetical protein; Provisional; Region: PRK10040 574521004562 pseudogene, transposase Orf2 of IS911, disrupted by ISEc21 574521004563 Transposase; Region: DEDD_Tnp_IS110; pfam01548 574521004564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 574521004565 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 574521004566 pseudogene, transposase Orf2 of IS911, disrupted by ISEc21 574521004567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 574521004568 Transposase; Region: HTH_Tnp_1; pfam01527 574521004569 pseudogene, transposase Orf2 of IS150, disrupted by ISEc13 at 5' end and truncated at 3' end 574521004570 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521004571 pseudogene, transposase Orf2 of IS150, N-ter part disrupted by ISEc13 574521004572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 574521004573 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521004574 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521004575 pseudogene, C-ter part of methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor 574521004576 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 574521004577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521004578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 574521004579 dimerization interface [polypeptide binding]; other site 574521004580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 574521004581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 574521004582 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 574521004583 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 574521004584 hypothetical protein; Provisional; Region: PRK11415 574521004585 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 574521004586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521004587 Coenzyme A binding pocket [chemical binding]; other site 574521004588 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 574521004589 putative trimer interface [polypeptide binding]; other site 574521004590 putative CoA binding site [chemical binding]; other site 574521004591 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 574521004592 putative trimer interface [polypeptide binding]; other site 574521004593 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 574521004594 putative CoA binding site [chemical binding]; other site 574521004595 putative trimer interface [polypeptide binding]; other site 574521004596 putative CoA binding site [chemical binding]; other site 574521004597 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 574521004598 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 574521004599 gating phenylalanine in ion channel; other site 574521004600 tellurite resistance protein TehB; Provisional; Region: PRK11207 574521004601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521004602 S-adenosylmethionine binding site [chemical binding]; other site 574521004603 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 574521004604 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 574521004605 benzoate transporter; Region: benE; TIGR00843 574521004606 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 574521004607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521004608 non-specific DNA binding site [nucleotide binding]; other site 574521004609 salt bridge; other site 574521004610 sequence-specific DNA binding site [nucleotide binding]; other site 574521004611 Cupin domain; Region: Cupin_2; pfam07883 574521004612 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 574521004613 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 574521004614 Peptidase family U32; Region: Peptidase_U32; pfam01136 574521004615 Collagenase; Region: DUF3656; pfam12392 574521004616 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 574521004617 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 574521004618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521004619 DNA-binding site [nucleotide binding]; DNA binding site 574521004620 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 574521004621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521004622 homodimer interface [polypeptide binding]; other site 574521004623 catalytic residue [active] 574521004624 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 574521004625 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 574521004626 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 574521004627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521004628 Walker A/P-loop; other site 574521004629 ATP binding site [chemical binding]; other site 574521004630 Q-loop/lid; other site 574521004631 ABC transporter signature motif; other site 574521004632 Walker B; other site 574521004633 D-loop; other site 574521004634 H-loop/switch region; other site 574521004635 TOBE domain; Region: TOBE_2; pfam08402 574521004636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521004637 dimer interface [polypeptide binding]; other site 574521004638 conserved gate region; other site 574521004639 putative PBP binding loops; other site 574521004640 ABC-ATPase subunit interface; other site 574521004641 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 574521004642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521004643 ABC-ATPase subunit interface; other site 574521004644 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 574521004645 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 574521004646 tetrameric interface [polypeptide binding]; other site 574521004647 NAD binding site [chemical binding]; other site 574521004648 catalytic residues [active] 574521004649 substrate binding site [chemical binding]; other site 574521004650 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 574521004651 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 574521004652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 574521004653 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 574521004654 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 574521004655 pseudogene, N-ter part of oxidoreductase 574521004656 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 574521004657 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 574521004658 N-terminal plug; other site 574521004659 ligand-binding site [chemical binding]; other site 574521004660 PQQ-like domain; Region: PQQ_2; pfam13360 574521004661 L-asparagine permease; Provisional; Region: PRK15049 574521004662 pseudogene, Rhs-family protein, fragment 574521004663 pseudogene, Rhs-family protein, fragment 574521004664 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 574521004665 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 574521004666 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 574521004667 hypothetical protein; Provisional; Region: PRK10281 574521004668 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 574521004669 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 574521004670 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 574521004671 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 574521004672 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 574521004673 [4Fe-4S] binding site [ion binding]; other site 574521004674 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 574521004675 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 574521004676 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 574521004677 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 574521004678 molybdopterin cofactor binding site; other site 574521004679 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 574521004680 aromatic amino acid exporter; Provisional; Region: PRK11689 574521004681 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 574521004682 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 574521004683 [4Fe-4S] binding site [ion binding]; other site 574521004684 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 574521004685 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 574521004686 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 574521004687 molybdopterin cofactor binding site; other site 574521004688 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 574521004689 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 574521004690 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 574521004691 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 574521004692 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 574521004693 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521004694 non-specific DNA binding site [nucleotide binding]; other site 574521004695 salt bridge; other site 574521004696 sequence-specific DNA binding site [nucleotide binding]; other site 574521004697 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 574521004698 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 574521004699 NAD binding site [chemical binding]; other site 574521004700 substrate binding site [chemical binding]; other site 574521004701 catalytic Zn binding site [ion binding]; other site 574521004702 tetramer interface [polypeptide binding]; other site 574521004703 structural Zn binding site [ion binding]; other site 574521004704 malate dehydrogenase; Provisional; Region: PRK13529 574521004705 Malic enzyme, N-terminal domain; Region: malic; pfam00390 574521004706 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 574521004707 NAD(P) binding site [chemical binding]; other site 574521004708 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 574521004709 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 574521004710 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 574521004711 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 574521004712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 574521004713 putative active site [active] 574521004714 heme pocket [chemical binding]; other site 574521004715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 574521004716 putative active site [active] 574521004717 heme pocket [chemical binding]; other site 574521004718 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 574521004719 metal binding site [ion binding]; metal-binding site 574521004720 active site 574521004721 I-site; other site 574521004722 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521004723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 574521004724 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 574521004725 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 574521004726 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 574521004727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521004728 catalytic residue [active] 574521004729 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 574521004730 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 574521004731 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 574521004732 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 574521004733 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 574521004734 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 574521004735 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 574521004736 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 574521004737 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 574521004738 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 574521004739 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 574521004740 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521004741 FeS/SAM binding site; other site 574521004742 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 574521004743 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 574521004744 Sulfatase; Region: Sulfatase; pfam00884 574521004745 transcriptional regulator YdeO; Provisional; Region: PRK09940 574521004746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521004747 putative oxidoreductase; Provisional; Region: PRK09939 574521004748 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 574521004749 putative molybdopterin cofactor binding site [chemical binding]; other site 574521004750 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 574521004751 putative molybdopterin cofactor binding site; other site 574521004752 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 574521004753 mannosyl binding site [chemical binding]; other site 574521004754 Fimbrial protein; Region: Fimbrial; pfam00419 574521004755 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 574521004756 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 574521004757 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 574521004758 PapC N-terminal domain; Region: PapC_N; pfam13954 574521004759 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 574521004760 PapC C-terminal domain; Region: PapC_C; pfam13953 574521004761 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 574521004762 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 574521004763 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 574521004764 Fimbrial protein; Region: Fimbrial; cl01416 574521004765 Restriction endonuclease; Region: Mrr_cat; pfam04471 574521004766 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 574521004767 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 574521004768 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 574521004769 NTP binding site [chemical binding]; other site 574521004770 HipA N-terminal domain; Region: Couple_hipA; pfam13657 574521004771 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 574521004772 HipA-like N-terminal domain; Region: HipA_N; pfam07805 574521004773 HipA-like C-terminal domain; Region: HipA_C; pfam07804 574521004774 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 574521004775 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521004776 non-specific DNA binding site [nucleotide binding]; other site 574521004777 salt bridge; other site 574521004778 sequence-specific DNA binding site [nucleotide binding]; other site 574521004779 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 574521004780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521004781 S-adenosylmethionine binding site [chemical binding]; other site 574521004782 Predicted membrane protein [Function unknown]; Region: COG3781 574521004783 altronate oxidoreductase; Provisional; Region: PRK03643 574521004784 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 574521004785 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 574521004786 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 574521004787 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 574521004788 metal binding site [ion binding]; metal-binding site 574521004789 active site 574521004790 I-site; other site 574521004791 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 574521004792 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 574521004793 glutaminase; Provisional; Region: PRK00971 574521004794 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 574521004795 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 574521004796 NAD(P) binding site [chemical binding]; other site 574521004797 catalytic residues [active] 574521004798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 574521004799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521004800 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 574521004801 putative dimerization interface [polypeptide binding]; other site 574521004802 putative arabinose transporter; Provisional; Region: PRK03545 574521004803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521004804 putative substrate translocation pore; other site 574521004805 inner membrane protein; Provisional; Region: PRK10995 574521004806 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 574521004807 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 574521004808 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 574521004809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521004810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521004811 hypothetical protein; Provisional; Region: PRK10106 574521004812 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 574521004813 EamA-like transporter family; Region: EamA; pfam00892 574521004814 EamA-like transporter family; Region: EamA; pfam00892 574521004815 putative transporter; Provisional; Region: PRK10054 574521004816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521004817 putative substrate translocation pore; other site 574521004818 diguanylate cyclase; Provisional; Region: PRK09894 574521004819 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 574521004820 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 574521004821 metal binding site [ion binding]; metal-binding site 574521004822 active site 574521004823 I-site; other site 574521004824 pseudogene, C-ter part of conserved protein 574521004825 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 574521004826 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 574521004827 active site 574521004828 Zn binding site [ion binding]; other site 574521004829 malonic semialdehyde reductase; Provisional; Region: PRK10538 574521004830 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 574521004831 putative NAD(P) binding site [chemical binding]; other site 574521004832 homodimer interface [polypeptide binding]; other site 574521004833 homotetramer interface [polypeptide binding]; other site 574521004834 active site 574521004835 Transcriptional regulators [Transcription]; Region: GntR; COG1802 574521004836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521004837 DNA-binding site [nucleotide binding]; DNA binding site 574521004838 FCD domain; Region: FCD; pfam07729 574521004839 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 574521004840 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 574521004841 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 574521004842 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 574521004843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521004844 metabolite-proton symporter; Region: 2A0106; TIGR00883 574521004845 putative substrate translocation pore; other site 574521004846 putative oxidoreductase; Provisional; Region: PRK10083 574521004847 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 574521004848 putative NAD(P) binding site [chemical binding]; other site 574521004849 catalytic Zn binding site [ion binding]; other site 574521004850 structural Zn binding site [ion binding]; other site 574521004851 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 574521004852 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 574521004853 putative active site pocket [active] 574521004854 putative metal binding site [ion binding]; other site 574521004855 hypothetical protein; Provisional; Region: PRK02237 574521004856 hypothetical protein; Provisional; Region: PRK13659 574521004857 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 574521004858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521004859 Coenzyme A binding pocket [chemical binding]; other site 574521004860 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 574521004861 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 574521004862 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 574521004863 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 574521004864 putative [Fe4-S4] binding site [ion binding]; other site 574521004865 putative molybdopterin cofactor binding site [chemical binding]; other site 574521004866 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 574521004867 putative molybdopterin cofactor binding site; other site 574521004868 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 574521004869 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 574521004870 putative [Fe4-S4] binding site [ion binding]; other site 574521004871 putative molybdopterin cofactor binding site [chemical binding]; other site 574521004872 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 574521004873 putative molybdopterin cofactor binding site; other site 574521004874 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 574521004875 4Fe-4S binding domain; Region: Fer4; cl02805 574521004876 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 574521004877 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 574521004878 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 574521004879 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 574521004880 Cl- selectivity filter; other site 574521004881 Cl- binding residues [ion binding]; other site 574521004882 pore gating glutamate residue; other site 574521004883 dimer interface [polypeptide binding]; other site 574521004884 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 574521004885 AAA domain; Region: AAA_26; pfam13500 574521004886 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 574521004887 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 574521004888 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 574521004889 nucleotide binding site [chemical binding]; other site 574521004890 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 574521004891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521004892 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 574521004893 dimerization interface [polypeptide binding]; other site 574521004894 substrate binding pocket [chemical binding]; other site 574521004895 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 574521004896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521004897 putative substrate translocation pore; other site 574521004898 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 574521004899 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 574521004900 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 574521004901 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 574521004902 Domain of unknown function DUF20; Region: UPF0118; pfam01594 574521004903 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 574521004904 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 574521004905 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 574521004906 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 574521004907 ligand binding site [chemical binding]; other site 574521004908 homodimer interface [polypeptide binding]; other site 574521004909 NAD(P) binding site [chemical binding]; other site 574521004910 trimer interface B [polypeptide binding]; other site 574521004911 trimer interface A [polypeptide binding]; other site 574521004912 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 574521004913 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 574521004914 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 574521004915 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 574521004916 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 574521004917 Spore germination protein; Region: Spore_permease; cl17796 574521004918 dihydromonapterin reductase; Provisional; Region: PRK06483 574521004919 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 574521004920 NADP binding site [chemical binding]; other site 574521004921 substrate binding pocket [chemical binding]; other site 574521004922 active site 574521004923 GlpM protein; Region: GlpM; pfam06942 574521004924 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 574521004925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521004926 active site 574521004927 phosphorylation site [posttranslational modification] 574521004928 intermolecular recognition site; other site 574521004929 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521004930 DNA binding site [nucleotide binding] 574521004931 sensor protein RstB; Provisional; Region: PRK10604 574521004932 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 574521004933 dimerization interface [polypeptide binding]; other site 574521004934 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521004935 dimer interface [polypeptide binding]; other site 574521004936 phosphorylation site [posttranslational modification] 574521004937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521004938 ATP binding site [chemical binding]; other site 574521004939 Mg2+ binding site [ion binding]; other site 574521004940 G-X-G motif; other site 574521004941 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 574521004942 fumarate hydratase; Reviewed; Region: fumC; PRK00485 574521004943 Class II fumarases; Region: Fumarase_classII; cd01362 574521004944 active site 574521004945 tetramer interface [polypeptide binding]; other site 574521004946 fumarate hydratase; Provisional; Region: PRK15389 574521004947 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 574521004948 Fumarase C-terminus; Region: Fumerase_C; pfam05683 574521004949 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 574521004950 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 574521004951 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 574521004952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 574521004953 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 574521004954 pseudogene, outer membrane porin protein, truncated by premature stop codon 574521004955 glucuronide transporter; Provisional; Region: PRK09848 574521004956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521004957 putative substrate translocation pore; other site 574521004958 beta-D-glucuronidase; Provisional; Region: PRK10150 574521004959 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 574521004960 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 574521004961 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 574521004962 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 574521004963 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521004964 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 574521004965 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 574521004966 NAD binding site [chemical binding]; other site 574521004967 substrate binding site [chemical binding]; other site 574521004968 homotetramer interface [polypeptide binding]; other site 574521004969 homodimer interface [polypeptide binding]; other site 574521004970 active site 574521004971 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 574521004972 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521004973 DNA binding site [nucleotide binding] 574521004974 domain linker motif; other site 574521004975 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 574521004976 putative dimerization interface [polypeptide binding]; other site 574521004977 putative ligand binding site [chemical binding]; other site 574521004978 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 574521004979 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 574521004980 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 574521004981 active site turn [active] 574521004982 phosphorylation site [posttranslational modification] 574521004983 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 574521004984 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 574521004985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521004986 homodimer interface [polypeptide binding]; other site 574521004987 catalytic residue [active] 574521004988 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 574521004989 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 574521004990 active site 574521004991 purine riboside binding site [chemical binding]; other site 574521004992 Transposase IS200 like; Region: Y1_Tnp; pfam01797 574521004993 putative oxidoreductase; Provisional; Region: PRK11579 574521004994 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 574521004995 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 574521004996 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 574521004997 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 574521004998 electron transport complex protein RsxA; Provisional; Region: PRK05151 574521004999 electron transport complex protein RnfB; Provisional; Region: PRK05113 574521005000 Putative Fe-S cluster; Region: FeS; pfam04060 574521005001 4Fe-4S binding domain; Region: Fer4; pfam00037 574521005002 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 574521005003 SLBB domain; Region: SLBB; pfam10531 574521005004 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 574521005005 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 574521005006 electron transport complex protein RnfG; Validated; Region: PRK01908 574521005007 electron transport complex RsxE subunit; Provisional; Region: PRK12405 574521005008 endonuclease III; Provisional; Region: PRK10702 574521005009 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 574521005010 minor groove reading motif; other site 574521005011 helix-hairpin-helix signature motif; other site 574521005012 substrate binding pocket [chemical binding]; other site 574521005013 active site 574521005014 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 574521005015 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 574521005016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521005017 putative substrate translocation pore; other site 574521005018 POT family; Region: PTR2; pfam00854 574521005019 glutathionine S-transferase; Provisional; Region: PRK10542 574521005020 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 574521005021 C-terminal domain interface [polypeptide binding]; other site 574521005022 GSH binding site (G-site) [chemical binding]; other site 574521005023 dimer interface [polypeptide binding]; other site 574521005024 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 574521005025 N-terminal domain interface [polypeptide binding]; other site 574521005026 dimer interface [polypeptide binding]; other site 574521005027 substrate binding pocket (H-site) [chemical binding]; other site 574521005028 pyridoxamine kinase; Validated; Region: PRK05756 574521005029 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 574521005030 dimer interface [polypeptide binding]; other site 574521005031 pyridoxal binding site [chemical binding]; other site 574521005032 ATP binding site [chemical binding]; other site 574521005033 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 574521005034 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 574521005035 active site 574521005036 HIGH motif; other site 574521005037 dimer interface [polypeptide binding]; other site 574521005038 KMSKS motif; other site 574521005039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 574521005040 RNA binding surface [nucleotide binding]; other site 574521005041 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 574521005042 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 574521005043 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 574521005044 lysozyme inhibitor; Provisional; Region: PRK11372 574521005045 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 574521005046 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 574521005047 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 574521005048 transcriptional regulator SlyA; Provisional; Region: PRK03573 574521005049 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 574521005050 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 574521005051 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 574521005052 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521005053 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521005054 Fusaric acid resistance protein family; Region: FUSC; pfam04632 574521005055 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 574521005056 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 574521005057 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 574521005058 E-class dimer interface [polypeptide binding]; other site 574521005059 P-class dimer interface [polypeptide binding]; other site 574521005060 active site 574521005061 Cu2+ binding site [ion binding]; other site 574521005062 Zn2+ binding site [ion binding]; other site 574521005063 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 574521005064 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 574521005065 active site 574521005066 catalytic tetrad [active] 574521005067 Predicted Fe-S protein [General function prediction only]; Region: COG3313 574521005068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 574521005069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521005070 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 574521005071 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 574521005072 FMN binding site [chemical binding]; other site 574521005073 active site 574521005074 substrate binding site [chemical binding]; other site 574521005075 catalytic residue [active] 574521005076 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 574521005077 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 574521005078 dimer interface [polypeptide binding]; other site 574521005079 active site 574521005080 metal binding site [ion binding]; metal-binding site 574521005081 glutathione binding site [chemical binding]; other site 574521005082 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 574521005083 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 574521005084 dimer interface [polypeptide binding]; other site 574521005085 catalytic site [active] 574521005086 putative active site [active] 574521005087 putative substrate binding site [chemical binding]; other site 574521005088 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 574521005089 putative GSH binding site [chemical binding]; other site 574521005090 catalytic residues [active] 574521005091 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 574521005092 NlpC/P60 family; Region: NLPC_P60; pfam00877 574521005093 superoxide dismutase; Provisional; Region: PRK10543 574521005094 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 574521005095 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 574521005096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521005097 Major Facilitator Superfamily; Region: MFS_1; pfam07690 574521005098 putative substrate translocation pore; other site 574521005099 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 574521005100 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521005101 DNA binding site [nucleotide binding] 574521005102 domain linker motif; other site 574521005103 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 574521005104 dimerization interface [polypeptide binding]; other site 574521005105 ligand binding site [chemical binding]; other site 574521005106 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 574521005107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521005108 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 574521005109 dimerization interface [polypeptide binding]; other site 574521005110 putative transporter; Provisional; Region: PRK11043 574521005111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521005112 putative substrate translocation pore; other site 574521005113 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 574521005114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 574521005115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521005116 S-adenosylmethionine binding site [chemical binding]; other site 574521005117 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 574521005118 Lumazine binding domain; Region: Lum_binding; pfam00677 574521005119 Lumazine binding domain; Region: Lum_binding; pfam00677 574521005120 multidrug efflux protein; Reviewed; Region: PRK01766 574521005121 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 574521005122 cation binding site [ion binding]; other site 574521005123 hypothetical protein; Provisional; Region: PRK09945 574521005124 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 574521005125 putative monooxygenase; Provisional; Region: PRK11118 574521005126 hypothetical protein; Provisional; Region: PRK09897 574521005127 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 574521005128 hypothetical protein; Provisional; Region: PRK09946 574521005129 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 574521005130 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 574521005131 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 574521005132 hypothetical protein; Provisional; Region: PRK09947 574521005133 putative oxidoreductase; Provisional; Region: PRK09849 574521005134 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 574521005135 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 574521005136 hypothetical protein; Provisional; Region: PRK09898 574521005137 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 574521005138 hypothetical protein; Provisional; Region: PRK10292 574521005139 pyruvate kinase; Provisional; Region: PRK09206 574521005140 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 574521005141 domain interfaces; other site 574521005142 active site 574521005143 murein lipoprotein; Provisional; Region: PRK15396 574521005144 L,D-transpeptidase; Provisional; Region: PRK10190 574521005145 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 574521005146 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 574521005147 cysteine desufuration protein SufE; Provisional; Region: PRK09296 574521005148 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 574521005149 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 574521005150 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 574521005151 catalytic residue [active] 574521005152 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 574521005153 FeS assembly protein SufD; Region: sufD; TIGR01981 574521005154 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 574521005155 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 574521005156 Walker A/P-loop; other site 574521005157 ATP binding site [chemical binding]; other site 574521005158 Q-loop/lid; other site 574521005159 ABC transporter signature motif; other site 574521005160 Walker B; other site 574521005161 D-loop; other site 574521005162 H-loop/switch region; other site 574521005163 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 574521005164 putative ABC transporter; Region: ycf24; CHL00085 574521005165 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 574521005166 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 574521005167 CoenzymeA binding site [chemical binding]; other site 574521005168 subunit interaction site [polypeptide binding]; other site 574521005169 PHB binding site; other site 574521005170 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 574521005171 FAD binding domain; Region: FAD_binding_4; pfam01565 574521005172 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 574521005173 putative inner membrane protein; Provisional; Region: PRK10983 574521005174 Domain of unknown function DUF20; Region: UPF0118; pfam01594 574521005175 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 574521005176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521005177 Major Facilitator Superfamily; Region: MFS_1; pfam07690 574521005178 putative substrate translocation pore; other site 574521005179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521005180 putative substrate translocation pore; other site 574521005181 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 574521005182 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 574521005183 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 574521005184 shikimate binding site; other site 574521005185 NAD(P) binding site [chemical binding]; other site 574521005186 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 574521005187 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 574521005188 active site 574521005189 catalytic residue [active] 574521005190 dimer interface [polypeptide binding]; other site 574521005191 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 574521005192 Coenzyme A transferase; Region: CoA_trans; smart00882 574521005193 Coenzyme A transferase; Region: CoA_trans; cl17247 574521005194 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 574521005195 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 574521005196 active site 574521005197 Cupin domain; Region: Cupin_2; pfam07883 574521005198 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 574521005199 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 574521005200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521005201 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 574521005202 Ligand binding site [chemical binding]; other site 574521005203 Electron transfer flavoprotein domain; Region: ETF; pfam01012 574521005204 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 574521005205 Electron transfer flavoprotein domain; Region: ETF; smart00893 574521005206 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 574521005207 oxidoreductase; Provisional; Region: PRK10015 574521005208 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 574521005209 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 574521005210 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 574521005211 acyl-activating enzyme (AAE) consensus motif; other site 574521005212 putative AMP binding site [chemical binding]; other site 574521005213 putative active site [active] 574521005214 putative CoA binding site [chemical binding]; other site 574521005215 phosphoenolpyruvate synthase; Validated; Region: PRK06464 574521005216 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 574521005217 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 574521005218 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 574521005219 PEP synthetase regulatory protein; Provisional; Region: PRK05339 574521005220 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 574521005221 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 574521005222 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 574521005223 Uncharacterized conserved protein [Function unknown]; Region: COG0397 574521005224 hypothetical protein; Validated; Region: PRK00029 574521005225 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 574521005226 NlpC/P60 family; Region: NLPC_P60; pfam00877 574521005227 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 574521005228 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 574521005229 Walker A/P-loop; other site 574521005230 ATP binding site [chemical binding]; other site 574521005231 Q-loop/lid; other site 574521005232 ABC transporter signature motif; other site 574521005233 Walker B; other site 574521005234 D-loop; other site 574521005235 H-loop/switch region; other site 574521005236 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 574521005237 catalytic residues [active] 574521005238 dimer interface [polypeptide binding]; other site 574521005239 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 574521005240 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 574521005241 ABC-ATPase subunit interface; other site 574521005242 dimer interface [polypeptide binding]; other site 574521005243 putative PBP binding regions; other site 574521005244 prophage E2348_PP7, P2-like 574521005245 integrase; Provisional; Region: int; PHA02601 574521005246 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 574521005247 active site 574521005248 DNA binding site [nucleotide binding] 574521005249 Int/Topo IB signature motif; other site 574521005250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521005251 non-specific DNA binding site [nucleotide binding]; other site 574521005252 salt bridge; other site 574521005253 sequence-specific DNA binding site [nucleotide binding]; other site 574521005254 Transcriptional regulators [Transcription]; Region: MarR; COG1846 574521005255 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 574521005256 putative DNA binding site [nucleotide binding]; other site 574521005257 putative Zn2+ binding site [ion binding]; other site 574521005258 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 574521005259 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 574521005260 Mg binding site [ion binding]; other site 574521005261 nucleotide binding site [chemical binding]; other site 574521005262 putative protofilament interface [polypeptide binding]; other site 574521005263 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 574521005264 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 574521005265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521005266 Walker A motif; other site 574521005267 ATP binding site [chemical binding]; other site 574521005268 Walker B motif; other site 574521005269 arginine finger; other site 574521005270 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 574521005271 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 574521005272 active site 574521005273 catalytic triad [active] 574521005274 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 574521005275 Phage-related protein [Function unknown]; Region: COG4695; cl01923 574521005276 Phage portal protein; Region: Phage_portal; pfam04860 574521005277 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 574521005278 terminase ATPase subunit; Provisional; Region: P; PHA02535 574521005279 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 574521005280 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 574521005281 terminase endonuclease subunit; Provisional; Region: M; PHA02537 574521005282 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 574521005283 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 574521005284 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 574521005285 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 574521005286 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 574521005287 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 574521005288 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 574521005289 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 574521005290 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 574521005291 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 574521005292 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 574521005293 Baseplate J-like protein; Region: Baseplate_J; cl01294 574521005294 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 574521005295 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 574521005296 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 574521005297 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 574521005298 Phage Tail Collar Domain; Region: Collar; pfam07484 574521005299 Phage Tail Collar Domain; Region: Collar; pfam07484 574521005300 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 574521005301 Phage Tail Collar Domain; Region: Collar; pfam07484 574521005302 multiple promoter invertase; Provisional; Region: mpi; PRK13413 574521005303 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 574521005304 catalytic residues [active] 574521005305 catalytic nucleophile [active] 574521005306 Presynaptic Site I dimer interface [polypeptide binding]; other site 574521005307 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 574521005308 Synaptic Flat tetramer interface [polypeptide binding]; other site 574521005309 Synaptic Site I dimer interface [polypeptide binding]; other site 574521005310 DNA binding site [nucleotide binding] 574521005311 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 574521005312 DNA-binding interface [nucleotide binding]; DNA binding site 574521005313 Phage protein U [General function prediction only]; Region: COG3499 574521005314 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 574521005315 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 574521005316 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 574521005317 Phage tail tube protein FII; Region: Phage_tube; cl01390 574521005318 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 574521005319 tail protein; Provisional; Region: D; PHA02561 574521005320 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 574521005321 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 574521005322 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 574521005323 IHF dimer interface [polypeptide binding]; other site 574521005324 IHF - DNA interface [nucleotide binding]; other site 574521005325 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 574521005326 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 574521005327 putative tRNA-binding site [nucleotide binding]; other site 574521005328 B3/4 domain; Region: B3_4; pfam03483 574521005329 tRNA synthetase B5 domain; Region: B5; smart00874 574521005330 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 574521005331 dimer interface [polypeptide binding]; other site 574521005332 motif 1; other site 574521005333 motif 3; other site 574521005334 motif 2; other site 574521005335 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 574521005336 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 574521005337 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 574521005338 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 574521005339 dimer interface [polypeptide binding]; other site 574521005340 motif 1; other site 574521005341 active site 574521005342 motif 2; other site 574521005343 motif 3; other site 574521005344 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 574521005345 23S rRNA binding site [nucleotide binding]; other site 574521005346 L21 binding site [polypeptide binding]; other site 574521005347 L13 binding site [polypeptide binding]; other site 574521005348 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 574521005349 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 574521005350 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 574521005351 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 574521005352 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 574521005353 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 574521005354 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 574521005355 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 574521005356 active site 574521005357 dimer interface [polypeptide binding]; other site 574521005358 motif 1; other site 574521005359 motif 2; other site 574521005360 motif 3; other site 574521005361 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 574521005362 anticodon binding site; other site 574521005363 pseudogene, T3SS effector-like protein EspL homolog, fragmented by multiple mutations 574521005364 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 574521005365 6-phosphofructokinase 2; Provisional; Region: PRK10294 574521005366 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 574521005367 putative substrate binding site [chemical binding]; other site 574521005368 putative ATP binding site [chemical binding]; other site 574521005369 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 574521005370 Phosphotransferase enzyme family; Region: APH; pfam01636 574521005371 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 574521005372 active site 574521005373 ATP binding site [chemical binding]; other site 574521005374 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 574521005375 YniB-like protein; Region: YniB; pfam14002 574521005376 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 574521005377 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 574521005378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521005379 motif II; other site 574521005380 inner membrane protein; Provisional; Region: PRK11648 574521005381 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 574521005382 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 574521005383 cell division modulator; Provisional; Region: PRK10113 574521005384 hydroperoxidase II; Provisional; Region: katE; PRK11249 574521005385 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 574521005386 tetramer interface [polypeptide binding]; other site 574521005387 heme binding pocket [chemical binding]; other site 574521005388 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 574521005389 domain interactions; other site 574521005390 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 574521005391 putative active site [active] 574521005392 YdjC motif; other site 574521005393 Mg binding site [ion binding]; other site 574521005394 putative homodimer interface [polypeptide binding]; other site 574521005395 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 574521005396 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 574521005397 NAD binding site [chemical binding]; other site 574521005398 sugar binding site [chemical binding]; other site 574521005399 divalent metal binding site [ion binding]; other site 574521005400 tetramer (dimer of dimers) interface [polypeptide binding]; other site 574521005401 dimer interface [polypeptide binding]; other site 574521005402 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 574521005403 Cupin domain; Region: Cupin_2; pfam07883 574521005404 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521005405 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 574521005406 methionine cluster; other site 574521005407 active site 574521005408 phosphorylation site [posttranslational modification] 574521005409 metal binding site [ion binding]; metal-binding site 574521005410 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 574521005411 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 574521005412 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 574521005413 active site 574521005414 P-loop; other site 574521005415 phosphorylation site [posttranslational modification] 574521005416 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 574521005417 NAD+ synthetase; Region: nadE; TIGR00552 574521005418 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 574521005419 homodimer interface [polypeptide binding]; other site 574521005420 NAD binding pocket [chemical binding]; other site 574521005421 ATP binding pocket [chemical binding]; other site 574521005422 Mg binding site [ion binding]; other site 574521005423 active-site loop [active] 574521005424 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 574521005425 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 574521005426 GIY-YIG motif/motif A; other site 574521005427 active site 574521005428 catalytic site [active] 574521005429 putative DNA binding site [nucleotide binding]; other site 574521005430 metal binding site [ion binding]; metal-binding site 574521005431 hypothetical protein; Provisional; Region: PRK11396 574521005432 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 574521005433 dimer interface [polypeptide binding]; other site 574521005434 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 574521005435 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 574521005436 putative active site [active] 574521005437 Zn binding site [ion binding]; other site 574521005438 succinylarginine dihydrolase; Provisional; Region: PRK13281 574521005439 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 574521005440 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 574521005441 NAD(P) binding site [chemical binding]; other site 574521005442 catalytic residues [active] 574521005443 arginine succinyltransferase; Provisional; Region: PRK10456 574521005444 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 574521005445 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 574521005446 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 574521005447 inhibitor-cofactor binding pocket; inhibition site 574521005448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521005449 catalytic residue [active] 574521005450 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 574521005451 putative catalytic site [active] 574521005452 putative phosphate binding site [ion binding]; other site 574521005453 active site 574521005454 metal binding site A [ion binding]; metal-binding site 574521005455 DNA binding site [nucleotide binding] 574521005456 putative AP binding site [nucleotide binding]; other site 574521005457 putative metal binding site B [ion binding]; other site 574521005458 Uncharacterized conserved protein [Function unknown]; Region: COG0398 574521005459 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 574521005460 Uncharacterized conserved protein [Function unknown]; Region: COG0398 574521005461 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 574521005462 Uncharacterized conserved protein [Function unknown]; Region: COG2128 574521005463 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 574521005464 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 574521005465 hypothetical protein; Provisional; Region: PRK11622 574521005466 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 574521005467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521005468 putative PBP binding loops; other site 574521005469 ABC-ATPase subunit interface; other site 574521005470 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 574521005471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521005472 Walker A/P-loop; other site 574521005473 ATP binding site [chemical binding]; other site 574521005474 Q-loop/lid; other site 574521005475 ABC transporter signature motif; other site 574521005476 Walker B; other site 574521005477 D-loop; other site 574521005478 H-loop/switch region; other site 574521005479 Rhodanese Homology Domain; Region: RHOD; smart00450 574521005480 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 574521005481 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 574521005482 active site residue [active] 574521005483 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 574521005484 active site residue [active] 574521005485 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 574521005486 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 574521005487 active site 574521005488 8-oxo-dGMP binding site [chemical binding]; other site 574521005489 nudix motif; other site 574521005490 metal binding site [ion binding]; metal-binding site 574521005491 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 574521005492 glutamate dehydrogenase; Provisional; Region: PRK09414 574521005493 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 574521005494 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 574521005495 NAD(P) binding site [chemical binding]; other site 574521005496 DNA topoisomerase III; Provisional; Region: PRK07726 574521005497 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 574521005498 active site 574521005499 putative interdomain interaction site [polypeptide binding]; other site 574521005500 putative metal-binding site [ion binding]; other site 574521005501 putative nucleotide binding site [chemical binding]; other site 574521005502 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 574521005503 domain I; other site 574521005504 DNA binding groove [nucleotide binding] 574521005505 phosphate binding site [ion binding]; other site 574521005506 domain II; other site 574521005507 domain III; other site 574521005508 nucleotide binding site [chemical binding]; other site 574521005509 catalytic site [active] 574521005510 domain IV; other site 574521005511 selenophosphate synthetase; Provisional; Region: PRK00943 574521005512 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 574521005513 dimerization interface [polypeptide binding]; other site 574521005514 putative ATP binding site [chemical binding]; other site 574521005515 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 574521005516 putative FMN binding site [chemical binding]; other site 574521005517 protease 4; Provisional; Region: PRK10949 574521005518 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 574521005519 tandem repeat interface [polypeptide binding]; other site 574521005520 oligomer interface [polypeptide binding]; other site 574521005521 active site residues [active] 574521005522 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 574521005523 tandem repeat interface [polypeptide binding]; other site 574521005524 oligomer interface [polypeptide binding]; other site 574521005525 active site residues [active] 574521005526 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 574521005527 active site 574521005528 homodimer interface [polypeptide binding]; other site 574521005529 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 574521005530 Isochorismatase family; Region: Isochorismatase; pfam00857 574521005531 catalytic triad [active] 574521005532 metal binding site [ion binding]; metal-binding site 574521005533 conserved cis-peptide bond; other site 574521005534 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 574521005535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521005536 putative substrate translocation pore; other site 574521005537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521005538 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 574521005539 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 574521005540 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 574521005541 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 574521005542 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 574521005543 active site 574521005544 catalytic tetrad [active] 574521005545 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 574521005546 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 574521005547 substrate binding site [chemical binding]; other site 574521005548 ATP binding site [chemical binding]; other site 574521005549 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 574521005550 intersubunit interface [polypeptide binding]; other site 574521005551 active site 574521005552 zinc binding site [ion binding]; other site 574521005553 Na+ binding site [ion binding]; other site 574521005554 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 574521005555 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 574521005556 inhibitor binding site; inhibition site 574521005557 catalytic Zn binding site [ion binding]; other site 574521005558 structural Zn binding site [ion binding]; other site 574521005559 NADP binding site [chemical binding]; other site 574521005560 tetramer interface [polypeptide binding]; other site 574521005561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521005562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521005563 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 574521005564 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 574521005565 putative NAD(P) binding site [chemical binding]; other site 574521005566 catalytic Zn binding site [ion binding]; other site 574521005567 structural Zn binding site [ion binding]; other site 574521005568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 574521005569 methionine sulfoxide reductase B; Provisional; Region: PRK00222 574521005570 SelR domain; Region: SelR; pfam01641 574521005571 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 574521005572 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 574521005573 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 574521005574 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 574521005575 active site 574521005576 phosphate binding residues; other site 574521005577 catalytic residues [active] 574521005578 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 574521005579 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 574521005580 active site 574521005581 catalytic tetrad [active] 574521005582 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 574521005583 PrkA family serine protein kinase; Provisional; Region: PRK15455 574521005584 AAA ATPase domain; Region: AAA_16; pfam13191 574521005585 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 574521005586 hypothetical protein; Provisional; Region: PRK05325 574521005587 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 574521005588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 574521005589 metal binding site [ion binding]; metal-binding site 574521005590 active site 574521005591 I-site; other site 574521005592 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 574521005593 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 574521005594 metal binding site [ion binding]; metal-binding site 574521005595 active site 574521005596 I-site; other site 574521005597 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 574521005598 putative deacylase active site [active] 574521005599 Predicted membrane protein [Function unknown]; Region: COG2707 574521005600 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 574521005601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521005602 cyanate transporter; Region: CynX; TIGR00896 574521005603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521005604 Uncharacterized conserved protein [Function unknown]; Region: COG3189 574521005605 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 574521005606 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 574521005607 Domain of unknown function (DUF333); Region: DUF333; pfam03891 574521005608 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 574521005609 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 574521005610 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 574521005611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 574521005612 metal binding site [ion binding]; metal-binding site 574521005613 active site 574521005614 I-site; other site 574521005615 hypothetical protein; Provisional; Region: PRK10457 574521005616 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 574521005617 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 574521005618 leucine export protein LeuE; Provisional; Region: PRK10958 574521005619 pseudogene, C-ter part of DNA-binding transcriptional regulator 574521005620 ribonuclease D; Provisional; Region: PRK10829 574521005621 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 574521005622 catalytic site [active] 574521005623 putative active site [active] 574521005624 putative substrate binding site [chemical binding]; other site 574521005625 Helicase and RNase D C-terminal; Region: HRDC; smart00341 574521005626 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 574521005627 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 574521005628 acyl-activating enzyme (AAE) consensus motif; other site 574521005629 putative AMP binding site [chemical binding]; other site 574521005630 putative active site [active] 574521005631 putative CoA binding site [chemical binding]; other site 574521005632 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 574521005633 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 574521005634 Glycoprotease family; Region: Peptidase_M22; pfam00814 574521005635 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 574521005636 DEAD/DEAH box helicase; Region: DEAD; pfam00270 574521005637 DEAD_2; Region: DEAD_2; pfam06733 574521005638 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 574521005639 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 574521005640 homotrimer interaction site [polypeptide binding]; other site 574521005641 putative active site [active] 574521005642 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 574521005643 hypothetical protein; Provisional; Region: PRK05114 574521005644 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 574521005645 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 574521005646 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 574521005647 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 574521005648 putative active site [active] 574521005649 putative CoA binding site [chemical binding]; other site 574521005650 nudix motif; other site 574521005651 metal binding site [ion binding]; metal-binding site 574521005652 L-serine deaminase; Provisional; Region: PRK15023 574521005653 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 574521005654 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 574521005655 phage resistance protein; Provisional; Region: PRK10551 574521005656 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 574521005657 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521005658 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 574521005659 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 574521005660 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 574521005661 Transporter associated domain; Region: CorC_HlyC; smart01091 574521005662 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 574521005663 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 574521005664 active pocket/dimerization site; other site 574521005665 active site 574521005666 phosphorylation site [posttranslational modification] 574521005667 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 574521005668 active site 574521005669 phosphorylation site [posttranslational modification] 574521005670 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 574521005671 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 574521005672 hypothetical protein; Provisional; Region: PRK02913 574521005673 hypothetical protein; Provisional; Region: PRK11469 574521005674 Domain of unknown function DUF; Region: DUF204; pfam02659 574521005675 Domain of unknown function DUF; Region: DUF204; pfam02659 574521005676 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 574521005677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521005678 S-adenosylmethionine binding site [chemical binding]; other site 574521005679 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 574521005680 DNA-binding site [nucleotide binding]; DNA binding site 574521005681 RNA-binding motif; other site 574521005682 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 574521005683 YebO-like protein; Region: YebO; pfam13974 574521005684 PhoPQ regulatory protein; Provisional; Region: PRK10299 574521005685 YobH-like protein; Region: YobH; pfam13996 574521005686 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 574521005687 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 574521005688 dimerization interface [polypeptide binding]; other site 574521005689 putative Zn2+ binding site [ion binding]; other site 574521005690 putative DNA binding site [nucleotide binding]; other site 574521005691 Bacterial transcriptional regulator; Region: IclR; pfam01614 574521005692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521005693 Major Facilitator Superfamily; Region: MFS_1; pfam07690 574521005694 putative substrate translocation pore; other site 574521005695 Predicted integral membrane protein [Function unknown]; Region: COG5521 574521005696 heat shock protein HtpX; Provisional; Region: PRK05457 574521005697 carboxy-terminal protease; Provisional; Region: PRK11186 574521005698 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 574521005699 protein binding site [polypeptide binding]; other site 574521005700 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 574521005701 Catalytic dyad [active] 574521005702 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 574521005703 ProP expression regulator; Provisional; Region: PRK04950 574521005704 ProQ/FINO family; Region: ProQ; pfam04352 574521005705 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 574521005706 GAF domain; Region: GAF_2; pfam13185 574521005707 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 574521005708 Paraquat-inducible protein A; Region: PqiA; pfam04403 574521005709 Paraquat-inducible protein A; Region: PqiA; pfam04403 574521005710 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 574521005711 mce related protein; Region: MCE; pfam02470 574521005712 mce related protein; Region: MCE; pfam02470 574521005713 mce related protein; Region: MCE; pfam02470 574521005714 mce related protein; Region: MCE; pfam02470 574521005715 mce related protein; Region: MCE; pfam02470 574521005716 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 574521005717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521005718 S-adenosylmethionine binding site [chemical binding]; other site 574521005719 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 574521005720 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 574521005721 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 574521005722 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 574521005723 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 574521005724 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 574521005725 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 574521005726 hypothetical protein; Provisional; Region: PRK10301 574521005727 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 574521005728 Predicted amidohydrolase [General function prediction only]; Region: COG0388 574521005729 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 574521005730 exodeoxyribonuclease X; Provisional; Region: PRK07983 574521005731 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 574521005732 active site 574521005733 catalytic site [active] 574521005734 substrate binding site [chemical binding]; other site 574521005735 protease 2; Provisional; Region: PRK10115 574521005736 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 574521005737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 574521005738 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 574521005739 putative metal binding site [ion binding]; other site 574521005740 hypothetical protein; Provisional; Region: PRK13680 574521005741 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 574521005742 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 574521005743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 574521005744 ATP-grasp domain; Region: ATP-grasp; pfam02222 574521005745 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 574521005746 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 574521005747 active site 574521005748 intersubunit interface [polypeptide binding]; other site 574521005749 catalytic residue [active] 574521005750 phosphogluconate dehydratase; Validated; Region: PRK09054 574521005751 6-phosphogluconate dehydratase; Region: edd; TIGR01196 574521005752 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 574521005753 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 574521005754 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 574521005755 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 574521005756 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 574521005757 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 574521005758 putative active site [active] 574521005759 pyruvate kinase; Provisional; Region: PRK05826 574521005760 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 574521005761 domain interfaces; other site 574521005762 active site 574521005763 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 574521005764 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 574521005765 putative acyl-acceptor binding pocket; other site 574521005766 putative peptidase; Provisional; Region: PRK11649 574521005767 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 574521005768 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 574521005769 Peptidase family M23; Region: Peptidase_M23; pfam01551 574521005770 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 574521005771 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 574521005772 metal binding site [ion binding]; metal-binding site 574521005773 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 574521005774 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 574521005775 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 574521005776 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 574521005777 ABC-ATPase subunit interface; other site 574521005778 dimer interface [polypeptide binding]; other site 574521005779 putative PBP binding regions; other site 574521005780 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 574521005781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521005782 Walker A motif; other site 574521005783 ATP binding site [chemical binding]; other site 574521005784 Walker B motif; other site 574521005785 arginine finger; other site 574521005786 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 574521005787 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 574521005788 RuvA N terminal domain; Region: RuvA_N; pfam01330 574521005789 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 574521005790 hypothetical protein; Provisional; Region: PRK11470 574521005791 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 574521005792 active site 574521005793 putative DNA-binding cleft [nucleotide binding]; other site 574521005794 dimer interface [polypeptide binding]; other site 574521005795 hypothetical protein; Validated; Region: PRK00110 574521005796 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 574521005797 nudix motif; other site 574521005798 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 574521005799 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 574521005800 dimer interface [polypeptide binding]; other site 574521005801 anticodon binding site; other site 574521005802 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 574521005803 homodimer interface [polypeptide binding]; other site 574521005804 motif 1; other site 574521005805 active site 574521005806 motif 2; other site 574521005807 GAD domain; Region: GAD; pfam02938 574521005808 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 574521005809 motif 3; other site 574521005810 Isochorismatase family; Region: Isochorismatase; pfam00857 574521005811 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 574521005812 catalytic triad [active] 574521005813 conserved cis-peptide bond; other site 574521005814 hypothetical protein; Provisional; Region: PRK10302 574521005815 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 574521005816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521005817 S-adenosylmethionine binding site [chemical binding]; other site 574521005818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521005819 S-adenosylmethionine binding site [chemical binding]; other site 574521005820 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 574521005821 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 574521005822 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 574521005823 molybdopterin cofactor binding site [chemical binding]; other site 574521005824 substrate binding site [chemical binding]; other site 574521005825 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 574521005826 molybdopterin cofactor binding site; other site 574521005827 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 574521005828 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 574521005829 copper homeostasis protein CutC; Provisional; Region: PRK11572 574521005830 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 574521005831 putative metal binding site [ion binding]; other site 574521005832 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 574521005833 arginyl-tRNA synthetase; Region: argS; TIGR00456 574521005834 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 574521005835 active site 574521005836 HIGH motif; other site 574521005837 KMSK motif region; other site 574521005838 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 574521005839 tRNA binding surface [nucleotide binding]; other site 574521005840 anticodon binding site; other site 574521005841 Flagellar protein FlhE; Region: FlhE; pfam06366 574521005842 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 574521005843 FHIPEP family; Region: FHIPEP; pfam00771 574521005844 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 574521005845 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 574521005846 chemotaxis regulator CheZ; Provisional; Region: PRK11166 574521005847 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 574521005848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521005849 active site 574521005850 phosphorylation site [posttranslational modification] 574521005851 intermolecular recognition site; other site 574521005852 dimerization interface [polypeptide binding]; other site 574521005853 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 574521005854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521005855 active site 574521005856 phosphorylation site [posttranslational modification] 574521005857 intermolecular recognition site; other site 574521005858 dimerization interface [polypeptide binding]; other site 574521005859 CheB methylesterase; Region: CheB_methylest; pfam01339 574521005860 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 574521005861 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 574521005862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521005863 S-adenosylmethionine binding site [chemical binding]; other site 574521005864 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 574521005865 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 574521005866 dimer interface [polypeptide binding]; other site 574521005867 ligand binding site [chemical binding]; other site 574521005868 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 574521005869 dimerization interface [polypeptide binding]; other site 574521005870 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 574521005871 dimer interface [polypeptide binding]; other site 574521005872 putative CheW interface [polypeptide binding]; other site 574521005873 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 574521005874 putative CheA interaction surface; other site 574521005875 chemotaxis protein CheA; Provisional; Region: PRK10547 574521005876 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 574521005877 putative binding surface; other site 574521005878 active site 574521005879 CheY binding; Region: CheY-binding; pfam09078 574521005880 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 574521005881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521005882 ATP binding site [chemical binding]; other site 574521005883 Mg2+ binding site [ion binding]; other site 574521005884 G-X-G motif; other site 574521005885 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 574521005886 flagellar motor protein MotB; Validated; Region: motB; PRK09041 574521005887 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 574521005888 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 574521005889 ligand binding site [chemical binding]; other site 574521005890 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 574521005891 flagellar motor protein MotA; Validated; Region: PRK09110 574521005892 transcriptional activator FlhC; Provisional; Region: PRK12722 574521005893 transcriptional activator FlhD; Provisional; Region: PRK02909 574521005894 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 574521005895 Ligand Binding Site [chemical binding]; other site 574521005896 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 574521005897 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 574521005898 active site 574521005899 homotetramer interface [polypeptide binding]; other site 574521005900 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 574521005901 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 574521005902 pseudogene, fused L-arabinose transporter subunits of ABC superfamily: membrane components, disrupted by ISEc13 574521005903 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521005904 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 574521005905 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 574521005906 Walker A/P-loop; other site 574521005907 ATP binding site [chemical binding]; other site 574521005908 Q-loop/lid; other site 574521005909 ABC transporter signature motif; other site 574521005910 Walker B; other site 574521005911 D-loop; other site 574521005912 H-loop/switch region; other site 574521005913 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 574521005914 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 574521005915 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 574521005916 ligand binding site [chemical binding]; other site 574521005917 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 574521005918 Ferritin-like domain; Region: Ferritin; pfam00210 574521005919 ferroxidase diiron center [ion binding]; other site 574521005920 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 574521005921 YecR-like lipoprotein; Region: YecR; pfam13992 574521005922 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 574521005923 Ferritin-like domain; Region: Ferritin; pfam00210 574521005924 ferroxidase diiron center [ion binding]; other site 574521005925 probable metal-binding protein; Region: matur_matur; TIGR03853 574521005926 tyrosine transporter TyrP; Provisional; Region: PRK15132 574521005927 aromatic amino acid transport protein; Region: araaP; TIGR00837 574521005928 hypothetical protein; Provisional; Region: PRK10396 574521005929 yecA family protein; Region: ygfB_yecA; TIGR02292 574521005930 SEC-C motif; Region: SEC-C; pfam02810 574521005931 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 574521005932 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 574521005933 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 574521005934 GIY-YIG motif/motif A; other site 574521005935 active site 574521005936 catalytic site [active] 574521005937 putative DNA binding site [nucleotide binding]; other site 574521005938 metal binding site [ion binding]; metal-binding site 574521005939 UvrB/uvrC motif; Region: UVR; pfam02151 574521005940 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 574521005941 Helix-hairpin-helix motif; Region: HHH; pfam00633 574521005942 response regulator; Provisional; Region: PRK09483 574521005943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521005944 active site 574521005945 phosphorylation site [posttranslational modification] 574521005946 intermolecular recognition site; other site 574521005947 dimerization interface [polypeptide binding]; other site 574521005948 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521005949 DNA binding residues [nucleotide binding] 574521005950 dimerization interface [polypeptide binding]; other site 574521005951 hypothetical protein; Provisional; Region: PRK10613 574521005952 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 574521005953 Autoinducer binding domain; Region: Autoind_bind; pfam03472 574521005954 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521005955 DNA binding residues [nucleotide binding] 574521005956 dimerization interface [polypeptide binding]; other site 574521005957 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 574521005958 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 574521005959 Walker A/P-loop; other site 574521005960 ATP binding site [chemical binding]; other site 574521005961 Q-loop/lid; other site 574521005962 ABC transporter signature motif; other site 574521005963 Walker B; other site 574521005964 D-loop; other site 574521005965 H-loop/switch region; other site 574521005966 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 574521005967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521005968 dimer interface [polypeptide binding]; other site 574521005969 conserved gate region; other site 574521005970 putative PBP binding loops; other site 574521005971 ABC-ATPase subunit interface; other site 574521005972 D-cysteine desulfhydrase; Validated; Region: PRK03910 574521005973 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 574521005974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521005975 catalytic residue [active] 574521005976 cystine transporter subunit; Provisional; Region: PRK11260 574521005977 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521005978 substrate binding pocket [chemical binding]; other site 574521005979 membrane-bound complex binding site; other site 574521005980 hinge residues; other site 574521005981 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 574521005982 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 574521005983 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 574521005984 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 574521005985 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 574521005986 DNA binding residues [nucleotide binding] 574521005987 flagellin; Validated; Region: PRK08026 574521005988 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 574521005989 Flagellin protein; Region: FliC; pfam12445 574521005990 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 574521005991 flagellar capping protein; Reviewed; Region: fliD; PRK08032 574521005992 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 574521005993 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 574521005994 Flagellar protein FliS; Region: FliS; cl00654 574521005995 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 574521005996 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 574521005997 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 574521005998 active site 574521005999 Na/Ca binding site [ion binding]; other site 574521006000 catalytic site [active] 574521006001 pseudogene, conserved protein, truncated by frameshift mutation 574521006002 putative inner membrane protein; Provisional; Region: PRK11099 574521006003 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 574521006004 CPxP motif; other site 574521006005 hypothetical protein; Provisional; Region: PRK09951 574521006006 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 574521006007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521006008 Coenzyme A binding pocket [chemical binding]; other site 574521006009 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 574521006010 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 574521006011 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 574521006012 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 574521006013 flagellar motor switch protein FliG; Region: fliG; TIGR00207 574521006014 FliG C-terminal domain; Region: FliG_C; pfam01706 574521006015 flagellar assembly protein H; Validated; Region: fliH; PRK05687 574521006016 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 574521006017 Flagellar assembly protein FliH; Region: FliH; pfam02108 574521006018 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 574521006019 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 574521006020 Walker A motif/ATP binding site; other site 574521006021 Walker B motif; other site 574521006022 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 574521006023 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 574521006024 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 574521006025 flagellar hook-length control protein; Provisional; Region: PRK10118 574521006026 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 574521006027 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 574521006028 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 574521006029 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 574521006030 flagellar motor switch protein; Validated; Region: fliN; PRK05698 574521006031 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 574521006032 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 574521006033 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 574521006034 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 574521006035 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 574521006036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521006037 DNA binding residues [nucleotide binding] 574521006038 dimerization interface [polypeptide binding]; other site 574521006039 hypothetical protein; Provisional; Region: PRK10708 574521006040 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 574521006041 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 574521006042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521006043 active site 574521006044 motif I; other site 574521006045 motif II; other site 574521006046 pseudogene, diguanylate cyclase, truncated by frameshift mutation 574521006047 Uncharacterized small protein [Function unknown]; Region: COG5475 574521006048 hypothetical protein; Provisional; Region: PRK10062 574521006049 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 574521006050 EamA-like transporter family; Region: EamA; pfam00892 574521006051 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 574521006052 additional DNA contacts [nucleotide binding]; other site 574521006053 mismatch recognition site; other site 574521006054 active site 574521006055 zinc binding site [ion binding]; other site 574521006056 DNA intercalation site [nucleotide binding]; other site 574521006057 DNA cytosine methylase; Provisional; Region: PRK10458 574521006058 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 574521006059 cofactor binding site; other site 574521006060 DNA binding site [nucleotide binding] 574521006061 substrate interaction site [chemical binding]; other site 574521006062 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 574521006063 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 574521006064 Zn2+ binding site [ion binding]; other site 574521006065 Mg2+ binding site [ion binding]; other site 574521006066 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 574521006067 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 574521006068 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 574521006069 trimer interface [polypeptide binding]; other site 574521006070 eyelet of channel; other site 574521006071 chaperone protein HchA; Provisional; Region: PRK04155 574521006072 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 574521006073 dimer interface [polypeptide binding]; other site 574521006074 metal binding site [ion binding]; metal-binding site 574521006075 potential oxyanion hole; other site 574521006076 potential catalytic triad [active] 574521006077 conserved cys residue [active] 574521006078 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 574521006079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521006080 dimer interface [polypeptide binding]; other site 574521006081 phosphorylation site [posttranslational modification] 574521006082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521006083 ATP binding site [chemical binding]; other site 574521006084 Mg2+ binding site [ion binding]; other site 574521006085 G-X-G motif; other site 574521006086 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 574521006087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521006088 active site 574521006089 phosphorylation site [posttranslational modification] 574521006090 intermolecular recognition site; other site 574521006091 dimerization interface [polypeptide binding]; other site 574521006092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521006093 DNA binding site [nucleotide binding] 574521006094 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 574521006095 active site 574521006096 homotetramer interface [polypeptide binding]; other site 574521006097 TMAO/DMSO reductase; Reviewed; Region: PRK05363 574521006098 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 574521006099 Moco binding site; other site 574521006100 metal coordination site [ion binding]; other site 574521006101 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 574521006102 zinc/cadmium-binding protein; Provisional; Region: PRK10306 574521006103 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 574521006104 pseudogene, C-ter part of adhesin, fragmented by multiple mutations 574521006105 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 574521006106 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 574521006107 shikimate transporter; Provisional; Region: PRK09952 574521006108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521006109 putative substrate translocation pore; other site 574521006110 AMP nucleosidase; Provisional; Region: PRK08292 574521006111 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 574521006112 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 574521006113 hypothetical protein; Provisional; Region: PRK12378 574521006114 integrative element E2348_IE3 574521006115 E2348_IE3; pseudogene, transcriptional regulator, partial 574521006116 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 574521006117 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 574521006118 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 574521006119 E2348_IE3; pseudogene, MobA/MobL family plasmid mobilization protein, truncated by premature stop codon 574521006120 Conjugal transfer protein TraD; Region: TraD; pfam06412 574521006121 PilS N terminal; Region: PilS; pfam08805 574521006122 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 574521006123 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 574521006124 E2348_IE3; pseudogene, P4-family integrase, partial 574521006125 integrase; Provisional; Region: PRK09692 574521006126 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 574521006127 active site 574521006128 Int/Topo IB signature motif; other site 574521006129 Protein of unknown function DUF262; Region: DUF262; pfam03235 574521006130 Uncharacterized conserved protein [Function unknown]; Region: COG1479 574521006131 integrase; Provisional; Region: PRK09692 574521006132 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 574521006133 active site 574521006134 Int/Topo IB signature motif; other site 574521006135 MATE family multidrug exporter; Provisional; Region: PRK10189 574521006136 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 574521006137 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 574521006138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521006139 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 574521006140 putative substrate binding site [chemical binding]; other site 574521006141 dimerization interface [polypeptide binding]; other site 574521006142 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 574521006143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521006144 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 574521006145 putative dimerization interface [polypeptide binding]; other site 574521006146 L,D-transpeptidase; Provisional; Region: PRK10190 574521006147 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 574521006148 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 574521006149 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 574521006150 putative dimer interface [polypeptide binding]; other site 574521006151 active site pocket [active] 574521006152 putative cataytic base [active] 574521006153 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 574521006154 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 574521006155 homotrimer interface [polypeptide binding]; other site 574521006156 Walker A motif; other site 574521006157 GTP binding site [chemical binding]; other site 574521006158 Walker B motif; other site 574521006159 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 574521006160 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 574521006161 Sensory domain found in PocR; Region: PocR; pfam10114 574521006162 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521006163 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 574521006164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521006165 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 574521006166 amphipathic channel; other site 574521006167 Asn-Pro-Ala signature motifs; other site 574521006168 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 574521006169 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 574521006170 Hexamer interface [polypeptide binding]; other site 574521006171 Putative hexagonal pore residue; other site 574521006172 propanediol utilization protein PduB; Provisional; Region: PRK15415 574521006173 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 574521006174 putative hexamer interface [polypeptide binding]; other site 574521006175 putative hexagonal pore; other site 574521006176 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 574521006177 putative hexamer interface [polypeptide binding]; other site 574521006178 putative hexagonal pore; other site 574521006179 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 574521006180 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 574521006181 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 574521006182 alpha-beta subunit interface [polypeptide binding]; other site 574521006183 alpha-gamma subunit interface [polypeptide binding]; other site 574521006184 active site 574521006185 substrate and K+ binding site; other site 574521006186 K+ binding site [ion binding]; other site 574521006187 cobalamin binding site [chemical binding]; other site 574521006188 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 574521006189 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 574521006190 Cell division protein FtsA; Region: FtsA; cl17206 574521006191 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 574521006192 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 574521006193 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 574521006194 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 574521006195 Hexamer interface [polypeptide binding]; other site 574521006196 Putative hexagonal pore residue; other site 574521006197 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 574521006198 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 574521006199 putative hexamer interface [polypeptide binding]; other site 574521006200 putative hexagonal pore; other site 574521006201 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 574521006202 Propanediol utilisation protein PduL; Region: PduL; pfam06130 574521006203 Propanediol utilisation protein PduL; Region: PduL; pfam06130 574521006204 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 574521006205 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 574521006206 Hexamer/Pentamer interface [polypeptide binding]; other site 574521006207 central pore; other site 574521006208 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 574521006209 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 574521006210 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 574521006211 putative catalytic cysteine [active] 574521006212 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 574521006213 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 574521006214 putative active site [active] 574521006215 metal binding site [ion binding]; metal-binding site 574521006216 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 574521006217 SLBB domain; Region: SLBB; pfam10531 574521006218 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 574521006219 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 574521006220 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 574521006221 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 574521006222 putative hexamer interface [polypeptide binding]; other site 574521006223 putative hexagonal pore; other site 574521006224 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 574521006225 putative hexamer interface [polypeptide binding]; other site 574521006226 putative hexagonal pore; other site 574521006227 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 574521006228 putative hexamer interface [polypeptide binding]; other site 574521006229 putative hexagonal pore; other site 574521006230 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 574521006231 G1 box; other site 574521006232 GTP/Mg2+ binding site [chemical binding]; other site 574521006233 G2 box; other site 574521006234 G3 box; other site 574521006235 Switch II region; other site 574521006236 G4 box; other site 574521006237 G5 box; other site 574521006238 hypothetical protein; Provisional; Region: PRK05423 574521006239 Predicted membrane protein [Function unknown]; Region: COG1289 574521006240 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 574521006241 DNA gyrase inhibitor; Provisional; Region: PRK10016 574521006242 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 574521006243 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 574521006244 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 574521006245 exonuclease I; Provisional; Region: sbcB; PRK11779 574521006246 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 574521006247 active site 574521006248 catalytic site [active] 574521006249 substrate binding site [chemical binding]; other site 574521006250 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 574521006251 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 574521006252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521006253 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 574521006254 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 574521006255 dimerization interface [polypeptide binding]; other site 574521006256 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 574521006257 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 574521006258 putative NAD(P) binding site [chemical binding]; other site 574521006259 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 574521006260 antitoxin YefM; Provisional; Region: PRK11409 574521006261 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 574521006262 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 574521006263 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 574521006264 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 574521006265 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 574521006266 NAD binding site [chemical binding]; other site 574521006267 dimerization interface [polypeptide binding]; other site 574521006268 product binding site; other site 574521006269 substrate binding site [chemical binding]; other site 574521006270 zinc binding site [ion binding]; other site 574521006271 catalytic residues [active] 574521006272 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 574521006273 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 574521006274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521006275 homodimer interface [polypeptide binding]; other site 574521006276 catalytic residue [active] 574521006277 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 574521006278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521006279 active site 574521006280 motif I; other site 574521006281 motif II; other site 574521006282 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 574521006283 putative active site pocket [active] 574521006284 4-fold oligomerization interface [polypeptide binding]; other site 574521006285 metal binding residues [ion binding]; metal-binding site 574521006286 3-fold/trimer interface [polypeptide binding]; other site 574521006287 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 574521006288 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 574521006289 putative active site [active] 574521006290 oxyanion strand; other site 574521006291 catalytic triad [active] 574521006292 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 574521006293 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 574521006294 catalytic residues [active] 574521006295 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 574521006296 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 574521006297 substrate binding site [chemical binding]; other site 574521006298 glutamase interaction surface [polypeptide binding]; other site 574521006299 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 574521006300 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 574521006301 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 574521006302 metal binding site [ion binding]; metal-binding site 574521006303 chain length determinant protein WzzB; Provisional; Region: PRK15471 574521006304 Chain length determinant protein; Region: Wzz; pfam02706 574521006305 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 574521006306 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 574521006307 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 574521006308 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 574521006309 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 574521006310 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 574521006311 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 574521006312 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 574521006313 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 574521006314 GDP-Fucose binding site [chemical binding]; other site 574521006315 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 574521006316 active site 574521006317 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 574521006318 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 574521006319 trimer interface [polypeptide binding]; other site 574521006320 active site 574521006321 substrate binding site [chemical binding]; other site 574521006322 CoA binding site [chemical binding]; other site 574521006323 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 574521006324 phosphomannomutase CpsG; Provisional; Region: PRK15414 574521006325 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 574521006326 active site 574521006327 substrate binding site [chemical binding]; other site 574521006328 metal binding site [ion binding]; metal-binding site 574521006329 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 574521006330 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 574521006331 Substrate binding site; other site 574521006332 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 574521006333 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 574521006334 active site 574521006335 GDP-Mannose binding site [chemical binding]; other site 574521006336 dimer interface [polypeptide binding]; other site 574521006337 modified nudix motif 574521006338 metal binding site [ion binding]; metal-binding site 574521006339 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 574521006340 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 574521006341 NADP binding site [chemical binding]; other site 574521006342 active site 574521006343 putative substrate binding site [chemical binding]; other site 574521006344 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 574521006345 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 574521006346 NADP-binding site; other site 574521006347 homotetramer interface [polypeptide binding]; other site 574521006348 substrate binding site [chemical binding]; other site 574521006349 homodimer interface [polypeptide binding]; other site 574521006350 active site 574521006351 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 574521006352 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 574521006353 UDP-glucose 4-epimerase; Region: PLN02240 574521006354 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 574521006355 NAD binding site [chemical binding]; other site 574521006356 homodimer interface [polypeptide binding]; other site 574521006357 active site 574521006358 substrate binding site [chemical binding]; other site 574521006359 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 574521006360 active site 574521006361 tetramer interface; other site 574521006362 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 574521006363 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 574521006364 putative NAD(P) binding site [chemical binding]; other site 574521006365 active site 574521006366 putative substrate binding site [chemical binding]; other site 574521006367 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 574521006368 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 574521006369 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 574521006370 putative ADP-binding pocket [chemical binding]; other site 574521006371 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 574521006372 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 574521006373 colanic acid exporter; Provisional; Region: PRK10459 574521006374 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 574521006375 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 574521006376 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 574521006377 phosphomannomutase CpsG; Provisional; Region: PRK15414 574521006378 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 574521006379 active site 574521006380 substrate binding site [chemical binding]; other site 574521006381 metal binding site [ion binding]; metal-binding site 574521006382 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 574521006383 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 574521006384 Substrate binding site; other site 574521006385 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 574521006386 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 574521006387 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 574521006388 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 574521006389 active site 574521006390 GDP-Mannose binding site [chemical binding]; other site 574521006391 dimer interface [polypeptide binding]; other site 574521006392 modified nudix motif 574521006393 metal binding site [ion binding]; metal-binding site 574521006394 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 574521006395 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 574521006396 NADP binding site [chemical binding]; other site 574521006397 active site 574521006398 putative substrate binding site [chemical binding]; other site 574521006399 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 574521006400 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 574521006401 NADP-binding site; other site 574521006402 homotetramer interface [polypeptide binding]; other site 574521006403 substrate binding site [chemical binding]; other site 574521006404 homodimer interface [polypeptide binding]; other site 574521006405 active site 574521006406 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 574521006407 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 574521006408 putative trimer interface [polypeptide binding]; other site 574521006409 putative active site [active] 574521006410 putative substrate binding site [chemical binding]; other site 574521006411 putative CoA binding site [chemical binding]; other site 574521006412 putative glycosyl transferase; Provisional; Region: PRK10063 574521006413 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 574521006414 metal-binding site 574521006415 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 574521006416 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 574521006417 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 574521006418 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 574521006419 putative acyl transferase; Provisional; Region: PRK10191 574521006420 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 574521006421 trimer interface [polypeptide binding]; other site 574521006422 active site 574521006423 substrate binding site [chemical binding]; other site 574521006424 CoA binding site [chemical binding]; other site 574521006425 putative glycosyl transferase; Provisional; Region: PRK10018 574521006426 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 574521006427 active site 574521006428 tyrosine kinase; Provisional; Region: PRK11519 574521006429 Chain length determinant protein; Region: Wzz; pfam02706 574521006430 Chain length determinant protein; Region: Wzz; cl15801 574521006431 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 574521006432 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 574521006433 Low molecular weight phosphatase family; Region: LMWPc; cd00115 574521006434 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 574521006435 active site 574521006436 polysaccharide export protein Wza; Provisional; Region: PRK15078 574521006437 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 574521006438 SLBB domain; Region: SLBB; pfam10531 574521006439 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 574521006440 FOG: CBS domain [General function prediction only]; Region: COG0517 574521006441 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 574521006442 Transporter associated domain; Region: CorC_HlyC; smart01091 574521006443 putative assembly protein; Provisional; Region: PRK10833 574521006444 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 574521006445 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 574521006446 trimer interface [polypeptide binding]; other site 574521006447 active site 574521006448 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 574521006449 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 574521006450 ATP-binding site [chemical binding]; other site 574521006451 Sugar specificity; other site 574521006452 Pyrimidine base specificity; other site 574521006453 pseudogene, diguanylate cyclase, GGDEF domain signalling protein, disrupted by ISEc13 574521006454 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521006455 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 574521006456 AlkA N-terminal domain; Region: AlkA_N; smart01009 574521006457 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 574521006458 minor groove reading motif; other site 574521006459 helix-hairpin-helix signature motif; other site 574521006460 substrate binding pocket [chemical binding]; other site 574521006461 active site 574521006462 putative chaperone; Provisional; Region: PRK11678 574521006463 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 574521006464 nucleotide binding site [chemical binding]; other site 574521006465 putative NEF/HSP70 interaction site [polypeptide binding]; other site 574521006466 SBD interface [polypeptide binding]; other site 574521006467 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 574521006468 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 574521006469 substrate binding site [chemical binding]; other site 574521006470 activation loop (A-loop); other site 574521006471 Y-family of DNA polymerases; Region: PolY; cl12025 574521006472 Protein phosphatase 2C; Region: PP2C_2; pfam13672 574521006473 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 574521006474 metal ion-dependent adhesion site (MIDAS); other site 574521006475 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521006476 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 574521006477 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521006478 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521006479 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 574521006480 Protein export membrane protein; Region: SecD_SecF; cl14618 574521006481 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 574521006482 putative transporter; Provisional; Region: PRK10504 574521006483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521006484 putative substrate translocation pore; other site 574521006485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521006486 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 574521006487 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 574521006488 dimerization interface [polypeptide binding]; other site 574521006489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521006490 dimer interface [polypeptide binding]; other site 574521006491 phosphorylation site [posttranslational modification] 574521006492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521006493 ATP binding site [chemical binding]; other site 574521006494 Mg2+ binding site [ion binding]; other site 574521006495 G-X-G motif; other site 574521006496 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 574521006497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521006498 active site 574521006499 phosphorylation site [posttranslational modification] 574521006500 intermolecular recognition site; other site 574521006501 dimerization interface [polypeptide binding]; other site 574521006502 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521006503 DNA binding site [nucleotide binding] 574521006504 Uncharacterized conserved protein [Function unknown]; Region: COG3422 574521006505 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 574521006506 putative protease; Provisional; Region: PRK15452 574521006507 Peptidase family U32; Region: Peptidase_U32; pfam01136 574521006508 lipid kinase; Reviewed; Region: PRK13054 574521006509 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 574521006510 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 574521006511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521006512 motif II; other site 574521006513 polyol permease family; Region: 2A0118; TIGR00897 574521006514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521006515 putative substrate translocation pore; other site 574521006516 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 574521006517 N- and C-terminal domain interface [polypeptide binding]; other site 574521006518 D-xylulose kinase; Region: XylB; TIGR01312 574521006519 active site 574521006520 MgATP binding site [chemical binding]; other site 574521006521 catalytic site [active] 574521006522 metal binding site [ion binding]; metal-binding site 574521006523 xylulose binding site [chemical binding]; other site 574521006524 homodimer interface [polypeptide binding]; other site 574521006525 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 574521006526 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 574521006527 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 574521006528 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 574521006529 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 574521006530 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 574521006531 pseudogene, C-ter part of conserved protein, contains a frameshift 574521006532 pseudogene, C-ter part of ribitol dehydrogenase 574521006533 pseudogene, ribitol kinase, disrupted by multiple mutations 574521006534 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 574521006535 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 574521006536 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 574521006537 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 574521006538 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 574521006539 putative NAD(P) binding site [chemical binding]; other site 574521006540 catalytic Zn binding site [ion binding]; other site 574521006541 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 574521006542 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 574521006543 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 574521006544 active site 574521006545 P-loop; other site 574521006546 phosphorylation site [posttranslational modification] 574521006547 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 574521006548 active site 574521006549 phosphorylation site [posttranslational modification] 574521006550 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 574521006551 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 574521006552 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 574521006553 intersubunit interface [polypeptide binding]; other site 574521006554 active site 574521006555 zinc binding site [ion binding]; other site 574521006556 Na+ binding site [ion binding]; other site 574521006557 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 574521006558 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 574521006559 putative active site; other site 574521006560 catalytic residue [active] 574521006561 nucleoside transporter; Region: 2A0110; TIGR00889 574521006562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521006563 putative substrate translocation pore; other site 574521006564 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 574521006565 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 574521006566 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 574521006567 substrate binding site [chemical binding]; other site 574521006568 ATP binding site [chemical binding]; other site 574521006569 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 574521006570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521006571 DNA-binding site [nucleotide binding]; DNA binding site 574521006572 UTRA domain; Region: UTRA; pfam07702 574521006573 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 574521006574 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 574521006575 active site 574521006576 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 574521006577 dimer interface [polypeptide binding]; other site 574521006578 substrate binding site [chemical binding]; other site 574521006579 ATP binding site [chemical binding]; other site 574521006580 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 574521006581 substrate binding site [chemical binding]; other site 574521006582 multimerization interface [polypeptide binding]; other site 574521006583 ATP binding site [chemical binding]; other site 574521006584 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 574521006585 putative metal binding site [ion binding]; other site 574521006586 putative homodimer interface [polypeptide binding]; other site 574521006587 putative homotetramer interface [polypeptide binding]; other site 574521006588 putative homodimer-homodimer interface [polypeptide binding]; other site 574521006589 putative allosteric switch controlling residues; other site 574521006590 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 574521006591 Predicted integral membrane protein [Function unknown]; Region: COG5455 574521006592 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521006593 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 574521006594 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 574521006595 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 574521006596 PapC N-terminal domain; Region: PapC_N; pfam13954 574521006597 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 574521006598 PapC C-terminal domain; Region: PapC_C; pfam13953 574521006599 pseudogene, periplasmic pilin chaperone, truncated by frameshift mutation 574521006600 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 574521006601 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 574521006602 antiporter inner membrane protein; Provisional; Region: PRK11670 574521006603 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 574521006604 Walker A motif; other site 574521006605 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 574521006606 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 574521006607 active site 574521006608 HIGH motif; other site 574521006609 KMSKS motif; other site 574521006610 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 574521006611 tRNA binding surface [nucleotide binding]; other site 574521006612 anticodon binding site; other site 574521006613 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 574521006614 dimer interface [polypeptide binding]; other site 574521006615 putative tRNA-binding site [nucleotide binding]; other site 574521006616 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 574521006617 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 574521006618 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 574521006619 pseudogene, conserved protein, truncated by frameshift mutation 574521006620 similar to hypothetical protein 574521006621 MoxR-like ATPases [General function prediction only]; Region: COG0714 574521006622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521006623 Walker A motif; other site 574521006624 ATP binding site [chemical binding]; other site 574521006625 Walker B motif; other site 574521006626 arginine finger; other site 574521006627 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 574521006628 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 574521006629 metal ion-dependent adhesion site (MIDAS); other site 574521006630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 574521006631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 574521006632 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 574521006633 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 574521006634 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 574521006635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521006636 active site 574521006637 phosphorylation site [posttranslational modification] 574521006638 intermolecular recognition site; other site 574521006639 dimerization interface [polypeptide binding]; other site 574521006640 LytTr DNA-binding domain; Region: LytTR; pfam04397 574521006641 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 574521006642 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 574521006643 GAF domain; Region: GAF; pfam01590 574521006644 Histidine kinase; Region: His_kinase; pfam06580 574521006645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521006646 ATP binding site [chemical binding]; other site 574521006647 Mg2+ binding site [ion binding]; other site 574521006648 G-X-G motif; other site 574521006649 transcriptional regulator MirA; Provisional; Region: PRK15043 574521006650 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 574521006651 DNA binding residues [nucleotide binding] 574521006652 hypothetical protein; Provisional; Region: PRK13681 574521006653 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 574521006654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521006655 dimer interface [polypeptide binding]; other site 574521006656 conserved gate region; other site 574521006657 putative PBP binding loops; other site 574521006658 ABC-ATPase subunit interface; other site 574521006659 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 574521006660 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 574521006661 Walker A/P-loop; other site 574521006662 ATP binding site [chemical binding]; other site 574521006663 Q-loop/lid; other site 574521006664 ABC transporter signature motif; other site 574521006665 Walker B; other site 574521006666 D-loop; other site 574521006667 H-loop/switch region; other site 574521006668 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 574521006669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521006670 dimer interface [polypeptide binding]; other site 574521006671 conserved gate region; other site 574521006672 ABC-ATPase subunit interface; other site 574521006673 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 574521006674 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 574521006675 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 574521006676 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 574521006677 D-lactate dehydrogenase; Provisional; Region: PRK11183 574521006678 FAD binding domain; Region: FAD_binding_4; pfam01565 574521006679 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 574521006680 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 574521006681 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 574521006682 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 574521006683 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 574521006684 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 574521006685 oxidoreductase; Provisional; Region: PRK12743 574521006686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 574521006687 NAD(P) binding site [chemical binding]; other site 574521006688 active site 574521006689 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 574521006690 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 574521006691 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 574521006692 FMN binding site [chemical binding]; other site 574521006693 active site 574521006694 catalytic residues [active] 574521006695 substrate binding site [chemical binding]; other site 574521006696 hypothetical protein; Provisional; Region: PRK01821 574521006697 hypothetical protein; Provisional; Region: PRK10711 574521006698 cytidine deaminase; Provisional; Region: PRK09027 574521006699 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 574521006700 active site 574521006701 catalytic motif [active] 574521006702 Zn binding site [ion binding]; other site 574521006703 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 574521006704 active site 574521006705 catalytic motif [active] 574521006706 Zn binding site [ion binding]; other site 574521006707 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 574521006708 putative active site [active] 574521006709 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 574521006710 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 574521006711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 574521006712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521006713 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 574521006714 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 574521006715 homodimer interface [polypeptide binding]; other site 574521006716 active site 574521006717 FMN binding site [chemical binding]; other site 574521006718 substrate binding site [chemical binding]; other site 574521006719 4Fe-4S binding domain; Region: Fer4; pfam00037 574521006720 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 574521006721 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 574521006722 TM-ABC transporter signature motif; other site 574521006723 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 574521006724 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 574521006725 Walker A/P-loop; other site 574521006726 ATP binding site [chemical binding]; other site 574521006727 Q-loop/lid; other site 574521006728 ABC transporter signature motif; other site 574521006729 Walker B; other site 574521006730 D-loop; other site 574521006731 H-loop/switch region; other site 574521006732 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 574521006733 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 574521006734 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 574521006735 ligand binding site [chemical binding]; other site 574521006736 calcium binding site [ion binding]; other site 574521006737 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 574521006738 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521006739 DNA binding site [nucleotide binding] 574521006740 domain linker motif; other site 574521006741 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 574521006742 dimerization interface (closed form) [polypeptide binding]; other site 574521006743 ligand binding site [chemical binding]; other site 574521006744 Predicted membrane protein [Function unknown]; Region: COG2311 574521006745 hypothetical protein; Provisional; Region: PRK10835 574521006746 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 574521006747 homodecamer interface [polypeptide binding]; other site 574521006748 GTP cyclohydrolase I; Provisional; Region: PLN03044 574521006749 active site 574521006750 putative catalytic site residues [active] 574521006751 zinc binding site [ion binding]; other site 574521006752 GTP-CH-I/GFRP interaction surface; other site 574521006753 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 574521006754 S-formylglutathione hydrolase; Region: PLN02442 574521006755 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 574521006756 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 574521006757 N-terminal plug; other site 574521006758 ligand-binding site [chemical binding]; other site 574521006759 lysine transporter; Provisional; Region: PRK10836 574521006760 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 574521006761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521006762 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 574521006763 putative dimerization interface [polypeptide binding]; other site 574521006764 conserved hypothetical integral membrane protein; Region: TIGR00698 574521006765 endonuclease IV; Provisional; Region: PRK01060 574521006766 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 574521006767 AP (apurinic/apyrimidinic) site pocket; other site 574521006768 DNA interaction; other site 574521006769 Metal-binding active site; metal-binding site 574521006770 putative kinase; Provisional; Region: PRK09954 574521006771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 574521006772 putative DNA binding site [nucleotide binding]; other site 574521006773 putative Zn2+ binding site [ion binding]; other site 574521006774 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 574521006775 substrate binding site [chemical binding]; other site 574521006776 ATP binding site [chemical binding]; other site 574521006777 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 574521006778 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 574521006779 Nucleoside recognition; Region: Gate; pfam07670 574521006780 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 574521006781 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 574521006782 active site 574521006783 tetramer interface [polypeptide binding]; other site 574521006784 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 574521006785 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 574521006786 ligand binding site [chemical binding]; other site 574521006787 flexible hinge region; other site 574521006788 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 574521006789 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 574521006790 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 574521006791 Nucleoside recognition; Region: Gate; pfam07670 574521006792 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 574521006793 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 574521006794 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 574521006795 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 574521006796 substrate binding site [chemical binding]; other site 574521006797 ATP binding site [chemical binding]; other site 574521006798 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 574521006799 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 574521006800 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 574521006801 active site 574521006802 P-loop; other site 574521006803 phosphorylation site [posttranslational modification] 574521006804 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 574521006805 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 574521006806 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 574521006807 putative substrate binding site [chemical binding]; other site 574521006808 putative ATP binding site [chemical binding]; other site 574521006809 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 574521006810 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 574521006811 active site 574521006812 phosphorylation site [posttranslational modification] 574521006813 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 574521006814 dimerization domain swap beta strand [polypeptide binding]; other site 574521006815 regulatory protein interface [polypeptide binding]; other site 574521006816 active site 574521006817 regulatory phosphorylation site [posttranslational modification]; other site 574521006818 sugar efflux transporter B; Provisional; Region: PRK15011 574521006819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521006820 putative substrate translocation pore; other site 574521006821 Flagellin N-methylase; Region: FliB; pfam03692 574521006822 elongation factor P; Provisional; Region: PRK04542 574521006823 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 574521006824 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 574521006825 RNA binding site [nucleotide binding]; other site 574521006826 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 574521006827 RNA binding site [nucleotide binding]; other site 574521006828 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 574521006829 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 574521006830 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 574521006831 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 574521006832 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 574521006833 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 574521006834 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 574521006835 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 574521006836 active site 574521006837 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 574521006838 NlpC/P60 family; Region: NLPC_P60; pfam00877 574521006839 phage resistance protein; Provisional; Region: PRK10551 574521006840 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 574521006841 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521006842 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 574521006843 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 574521006844 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 574521006845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521006846 dimer interface [polypeptide binding]; other site 574521006847 conserved gate region; other site 574521006848 putative PBP binding loops; other site 574521006849 ABC-ATPase subunit interface; other site 574521006850 microcin C ABC transporter permease; Provisional; Region: PRK15021 574521006851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521006852 dimer interface [polypeptide binding]; other site 574521006853 conserved gate region; other site 574521006854 ABC-ATPase subunit interface; other site 574521006855 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 574521006856 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521006857 Walker A/P-loop; other site 574521006858 ATP binding site [chemical binding]; other site 574521006859 Q-loop/lid; other site 574521006860 ABC transporter signature motif; other site 574521006861 Walker B; other site 574521006862 D-loop; other site 574521006863 H-loop/switch region; other site 574521006864 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 574521006865 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521006866 Walker A/P-loop; other site 574521006867 ATP binding site [chemical binding]; other site 574521006868 Q-loop/lid; other site 574521006869 ABC transporter signature motif; other site 574521006870 Walker B; other site 574521006871 D-loop; other site 574521006872 H-loop/switch region; other site 574521006873 hypothetical protein; Provisional; Region: PRK11835 574521006874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521006875 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 574521006876 putative substrate translocation pore; other site 574521006877 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 574521006878 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 574521006879 RNA binding surface [nucleotide binding]; other site 574521006880 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 574521006881 active site 574521006882 uracil binding [chemical binding]; other site 574521006883 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 574521006884 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 574521006885 ATP binding site [chemical binding]; other site 574521006886 putative Mg++ binding site [ion binding]; other site 574521006887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521006888 nucleotide binding region [chemical binding]; other site 574521006889 ATP-binding site [chemical binding]; other site 574521006890 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 574521006891 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 574521006892 5S rRNA interface [nucleotide binding]; other site 574521006893 CTC domain interface [polypeptide binding]; other site 574521006894 L16 interface [polypeptide binding]; other site 574521006895 Nucleoid-associated protein [General function prediction only]; Region: COG3081 574521006896 nucleoid-associated protein NdpA; Validated; Region: PRK00378 574521006897 hypothetical protein; Provisional; Region: PRK13689 574521006898 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 574521006899 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 574521006900 Sulfatase; Region: Sulfatase; pfam00884 574521006901 pseudogene, autotransporter outer membrane protein, disrupted by multiple mutations 574521006902 transcriptional regulator NarP; Provisional; Region: PRK10403 574521006903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521006904 active site 574521006905 phosphorylation site [posttranslational modification] 574521006906 intermolecular recognition site; other site 574521006907 dimerization interface [polypeptide binding]; other site 574521006908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521006909 DNA binding residues [nucleotide binding] 574521006910 dimerization interface [polypeptide binding]; other site 574521006911 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 574521006912 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 574521006913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 574521006914 binding surface 574521006915 TPR motif; other site 574521006916 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 574521006917 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 574521006918 catalytic residues [active] 574521006919 central insert; other site 574521006920 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 574521006921 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 574521006922 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 574521006923 heme exporter protein CcmC; Region: ccmC; TIGR01191 574521006924 heme exporter protein CcmB; Region: ccmB; TIGR01190 574521006925 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 574521006926 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 574521006927 Walker A/P-loop; other site 574521006928 ATP binding site [chemical binding]; other site 574521006929 Q-loop/lid; other site 574521006930 ABC transporter signature motif; other site 574521006931 Walker B; other site 574521006932 D-loop; other site 574521006933 H-loop/switch region; other site 574521006934 cytochrome c-type protein NapC; Provisional; Region: PRK10617 574521006935 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 574521006936 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 574521006937 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 574521006938 4Fe-4S binding domain; Region: Fer4_5; pfam12801 574521006939 4Fe-4S binding domain; Region: Fer4_6; pfam12837 574521006940 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 574521006941 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 574521006942 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 574521006943 [4Fe-4S] binding site [ion binding]; other site 574521006944 molybdopterin cofactor binding site; other site 574521006945 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 574521006946 molybdopterin cofactor binding site; other site 574521006947 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 574521006948 ferredoxin-type protein; Provisional; Region: PRK10194 574521006949 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 574521006950 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 574521006951 secondary substrate binding site; other site 574521006952 primary substrate binding site; other site 574521006953 inhibition loop; other site 574521006954 dimerization interface [polypeptide binding]; other site 574521006955 malate:quinone oxidoreductase; Validated; Region: PRK05257 574521006956 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 574521006957 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 574521006958 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 574521006959 Walker A/P-loop; other site 574521006960 ATP binding site [chemical binding]; other site 574521006961 Q-loop/lid; other site 574521006962 ABC transporter signature motif; other site 574521006963 Walker B; other site 574521006964 D-loop; other site 574521006965 H-loop/switch region; other site 574521006966 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 574521006967 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 574521006968 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 574521006969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521006970 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 574521006971 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 574521006972 DNA binding site [nucleotide binding] 574521006973 active site 574521006974 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 574521006975 ApbE family; Region: ApbE; pfam02424 574521006976 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 574521006977 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 574521006978 trimer interface [polypeptide binding]; other site 574521006979 eyelet of channel; other site 574521006980 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 574521006981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521006982 ATP binding site [chemical binding]; other site 574521006983 G-X-G motif; other site 574521006984 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 574521006985 putative binding surface; other site 574521006986 active site 574521006987 transcriptional regulator RcsB; Provisional; Region: PRK10840 574521006988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521006989 active site 574521006990 phosphorylation site [posttranslational modification] 574521006991 intermolecular recognition site; other site 574521006992 dimerization interface [polypeptide binding]; other site 574521006993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521006994 DNA binding residues [nucleotide binding] 574521006995 dimerization interface [polypeptide binding]; other site 574521006996 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 574521006997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521006998 dimer interface [polypeptide binding]; other site 574521006999 phosphorylation site [posttranslational modification] 574521007000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521007001 ATP binding site [chemical binding]; other site 574521007002 Mg2+ binding site [ion binding]; other site 574521007003 G-X-G motif; other site 574521007004 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 574521007005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521007006 active site 574521007007 phosphorylation site [posttranslational modification] 574521007008 intermolecular recognition site; other site 574521007009 dimerization interface [polypeptide binding]; other site 574521007010 sensory histidine kinase AtoS; Provisional; Region: PRK11360 574521007011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 574521007012 putative active site [active] 574521007013 heme pocket [chemical binding]; other site 574521007014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521007015 dimer interface [polypeptide binding]; other site 574521007016 phosphorylation site [posttranslational modification] 574521007017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521007018 ATP binding site [chemical binding]; other site 574521007019 Mg2+ binding site [ion binding]; other site 574521007020 G-X-G motif; other site 574521007021 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 574521007022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521007023 active site 574521007024 phosphorylation site [posttranslational modification] 574521007025 intermolecular recognition site; other site 574521007026 dimerization interface [polypeptide binding]; other site 574521007027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521007028 Walker A motif; other site 574521007029 ATP binding site [chemical binding]; other site 574521007030 Walker B motif; other site 574521007031 arginine finger; other site 574521007032 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 574521007033 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 574521007034 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 574521007035 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 574521007036 putative acyltransferase; Provisional; Region: PRK05790 574521007037 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 574521007038 dimer interface [polypeptide binding]; other site 574521007039 active site 574521007040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 574521007041 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 574521007042 Predicted secreted protein [Function unknown]; Region: COG5445 574521007043 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 574521007044 Predicted secreted protein [Function unknown]; Region: COG5445 574521007045 Stage II sporulation protein; Region: SpoIID; pfam08486 574521007046 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 574521007047 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 574521007048 MG2 domain; Region: A2M_N; pfam01835 574521007049 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 574521007050 Alpha-2-macroglobulin family; Region: A2M; pfam00207 574521007051 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 574521007052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 574521007053 pseudogene, conserved protein, truncated by frameshift mutation 574521007054 DNA gyrase subunit A; Validated; Region: PRK05560 574521007055 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 574521007056 CAP-like domain; other site 574521007057 active site 574521007058 primary dimer interface [polypeptide binding]; other site 574521007059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 574521007060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 574521007061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 574521007062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 574521007063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 574521007064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 574521007065 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 574521007066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521007067 S-adenosylmethionine binding site [chemical binding]; other site 574521007068 adhesin; Provisional; Region: PRK09752 574521007069 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 574521007070 Autotransporter beta-domain; Region: Autotransporter; pfam03797 574521007071 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 574521007072 ATP cone domain; Region: ATP-cone; pfam03477 574521007073 Class I ribonucleotide reductase; Region: RNR_I; cd01679 574521007074 active site 574521007075 dimer interface [polypeptide binding]; other site 574521007076 catalytic residues [active] 574521007077 effector binding site; other site 574521007078 R2 peptide binding site; other site 574521007079 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 574521007080 dimer interface [polypeptide binding]; other site 574521007081 putative radical transfer pathway; other site 574521007082 diiron center [ion binding]; other site 574521007083 tyrosyl radical; other site 574521007084 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 574521007085 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 574521007086 catalytic loop [active] 574521007087 iron binding site [ion binding]; other site 574521007088 hypothetical protein; Provisional; Region: PRK09902 574521007089 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 574521007090 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 574521007091 active site 574521007092 catalytic site [active] 574521007093 metal binding site [ion binding]; metal-binding site 574521007094 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 574521007095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521007096 putative substrate translocation pore; other site 574521007097 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 574521007098 hydroxyglutarate oxidase; Provisional; Region: PRK11728 574521007099 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 574521007100 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 574521007101 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 574521007102 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 574521007103 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 574521007104 Cysteine-rich domain; Region: CCG; pfam02754 574521007105 Cysteine-rich domain; Region: CCG; pfam02754 574521007106 hypothetical protein; Provisional; Region: PRK09956 574521007107 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 574521007108 hypothetical protein; Provisional; Region: PRK09956 574521007109 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 574521007110 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 574521007111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521007112 putative substrate translocation pore; other site 574521007113 L-rhamnonate dehydratase; Provisional; Region: PRK15440 574521007114 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 574521007115 putative active site pocket [active] 574521007116 putative metal binding site [ion binding]; other site 574521007117 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 574521007118 Transcriptional regulator [Transcription]; Region: IclR; COG1414 574521007119 Bacterial transcriptional regulator; Region: IclR; pfam01614 574521007120 hypothetical protein; Provisional; Region: PRK03673 574521007121 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 574521007122 putative MPT binding site; other site 574521007123 Competence-damaged protein; Region: CinA; cl00666 574521007124 YfaZ precursor; Region: YfaZ; pfam07437 574521007125 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 574521007126 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 574521007127 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 574521007128 catalytic core [active] 574521007129 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 574521007130 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 574521007131 inhibitor-cofactor binding pocket; inhibition site 574521007132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521007133 catalytic residue [active] 574521007134 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 574521007135 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 574521007136 Ligand binding site; other site 574521007137 Putative Catalytic site; other site 574521007138 DXD motif; other site 574521007139 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 574521007140 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 574521007141 substrate binding site [chemical binding]; other site 574521007142 cosubstrate binding site; other site 574521007143 catalytic site [active] 574521007144 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 574521007145 active site 574521007146 hexamer interface [polypeptide binding]; other site 574521007147 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 574521007148 NAD binding site [chemical binding]; other site 574521007149 substrate binding site [chemical binding]; other site 574521007150 active site 574521007151 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 574521007152 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 574521007153 putative active site [active] 574521007154 putative catalytic site [active] 574521007155 putative Zn binding site [ion binding]; other site 574521007156 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 574521007157 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 574521007158 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 574521007159 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 574521007160 signal transduction protein PmrD; Provisional; Region: PRK15450 574521007161 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 574521007162 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 574521007163 acyl-activating enzyme (AAE) consensus motif; other site 574521007164 putative AMP binding site [chemical binding]; other site 574521007165 putative active site [active] 574521007166 putative CoA binding site [chemical binding]; other site 574521007167 O-succinylbenzoate synthase; Provisional; Region: PRK05105 574521007168 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 574521007169 active site 574521007170 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 574521007171 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 574521007172 substrate binding site [chemical binding]; other site 574521007173 oxyanion hole (OAH) forming residues; other site 574521007174 trimer interface [polypeptide binding]; other site 574521007175 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 574521007176 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 574521007177 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 574521007178 dimer interface [polypeptide binding]; other site 574521007179 tetramer interface [polypeptide binding]; other site 574521007180 PYR/PP interface [polypeptide binding]; other site 574521007181 TPP binding site [chemical binding]; other site 574521007182 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 574521007183 TPP-binding site; other site 574521007184 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 574521007185 isochorismate synthases; Region: isochor_syn; TIGR00543 574521007186 hypothetical protein; Provisional; Region: PRK10404 574521007187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521007188 Coenzyme A binding pocket [chemical binding]; other site 574521007189 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 574521007190 M28 Zn-Peptidases; Region: M28_like_1; cd05640 574521007191 Peptidase family M28; Region: Peptidase_M28; pfam04389 574521007192 metal binding site [ion binding]; metal-binding site 574521007193 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 574521007194 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 574521007195 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 574521007196 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 574521007197 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 574521007198 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 574521007199 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 574521007200 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 574521007201 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 574521007202 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 574521007203 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 574521007204 4Fe-4S binding domain; Region: Fer4; pfam00037 574521007205 4Fe-4S binding domain; Region: Fer4; pfam00037 574521007206 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 574521007207 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 574521007208 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 574521007209 catalytic loop [active] 574521007210 iron binding site [ion binding]; other site 574521007211 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 574521007212 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 574521007213 [4Fe-4S] binding site [ion binding]; other site 574521007214 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 574521007215 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 574521007216 SLBB domain; Region: SLBB; pfam10531 574521007217 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 574521007218 NADH dehydrogenase subunit E; Validated; Region: PRK07539 574521007219 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 574521007220 putative dimer interface [polypeptide binding]; other site 574521007221 [2Fe-2S] cluster binding site [ion binding]; other site 574521007222 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 574521007223 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 574521007224 NADH dehydrogenase subunit D; Validated; Region: PRK06075 574521007225 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 574521007226 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 574521007227 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 574521007228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521007229 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 574521007230 putative dimerization interface [polypeptide binding]; other site 574521007231 aminotransferase AlaT; Validated; Region: PRK09265 574521007232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 574521007233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521007234 homodimer interface [polypeptide binding]; other site 574521007235 catalytic residue [active] 574521007236 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 574521007237 Zn2+ binding site [ion binding]; other site 574521007238 Mg2+ binding site [ion binding]; other site 574521007239 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 574521007240 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 574521007241 TrkA-C domain; Region: TrkA_C; pfam02080 574521007242 TrkA-C domain; Region: TrkA_C; pfam02080 574521007243 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 574521007244 putative phosphatase; Provisional; Region: PRK11587 574521007245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521007246 motif II; other site 574521007247 hypothetical protein; Validated; Region: PRK05445 574521007248 hypothetical protein; Provisional; Region: PRK01816 574521007249 propionate/acetate kinase; Provisional; Region: PRK12379 574521007250 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 574521007251 phosphate acetyltransferase; Reviewed; Region: PRK05632 574521007252 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 574521007253 DRTGG domain; Region: DRTGG; pfam07085 574521007254 phosphate acetyltransferase; Region: pta; TIGR00651 574521007255 hypothetical protein; Provisional; Region: PRK11588 574521007256 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 574521007257 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 574521007258 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 574521007259 nudix motif; other site 574521007260 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 574521007261 active site 574521007262 metal binding site [ion binding]; metal-binding site 574521007263 homotetramer interface [polypeptide binding]; other site 574521007264 glutathione S-transferase; Provisional; Region: PRK15113 574521007265 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 574521007266 C-terminal domain interface [polypeptide binding]; other site 574521007267 GSH binding site (G-site) [chemical binding]; other site 574521007268 dimer interface [polypeptide binding]; other site 574521007269 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 574521007270 N-terminal domain interface [polypeptide binding]; other site 574521007271 putative dimer interface [polypeptide binding]; other site 574521007272 putative substrate binding pocket (H-site) [chemical binding]; other site 574521007273 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 574521007274 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 574521007275 C-terminal domain interface [polypeptide binding]; other site 574521007276 GSH binding site (G-site) [chemical binding]; other site 574521007277 dimer interface [polypeptide binding]; other site 574521007278 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 574521007279 N-terminal domain interface [polypeptide binding]; other site 574521007280 putative dimer interface [polypeptide binding]; other site 574521007281 active site 574521007282 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 574521007283 homooctamer interface [polypeptide binding]; other site 574521007284 active site 574521007285 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 574521007286 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 574521007287 putative NAD(P) binding site [chemical binding]; other site 574521007288 putative active site [active] 574521007289 putative transposase; Provisional; Region: PRK09857 574521007290 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 574521007291 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 574521007292 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 574521007293 Walker A/P-loop; other site 574521007294 ATP binding site [chemical binding]; other site 574521007295 Q-loop/lid; other site 574521007296 ABC transporter signature motif; other site 574521007297 Walker B; other site 574521007298 D-loop; other site 574521007299 H-loop/switch region; other site 574521007300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521007301 dimer interface [polypeptide binding]; other site 574521007302 conserved gate region; other site 574521007303 putative PBP binding loops; other site 574521007304 ABC-ATPase subunit interface; other site 574521007305 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 574521007306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521007307 dimer interface [polypeptide binding]; other site 574521007308 conserved gate region; other site 574521007309 putative PBP binding loops; other site 574521007310 ABC-ATPase subunit interface; other site 574521007311 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 574521007312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521007313 substrate binding pocket [chemical binding]; other site 574521007314 membrane-bound complex binding site; other site 574521007315 hinge residues; other site 574521007316 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 574521007317 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521007318 substrate binding pocket [chemical binding]; other site 574521007319 membrane-bound complex binding site; other site 574521007320 hinge residues; other site 574521007321 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 574521007322 Flavoprotein; Region: Flavoprotein; pfam02441 574521007323 amidophosphoribosyltransferase; Provisional; Region: PRK09246 574521007324 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 574521007325 active site 574521007326 tetramer interface [polypeptide binding]; other site 574521007327 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 574521007328 active site 574521007329 colicin V production protein; Provisional; Region: PRK10845 574521007330 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 574521007331 cell division protein DedD; Provisional; Region: PRK11633 574521007332 Sporulation related domain; Region: SPOR; pfam05036 574521007333 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 574521007334 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 574521007335 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 574521007336 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 574521007337 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 574521007338 hypothetical protein; Provisional; Region: PRK10847 574521007339 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 574521007340 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 574521007341 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 574521007342 dimerization interface 3.5A [polypeptide binding]; other site 574521007343 active site 574521007344 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 574521007345 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 574521007346 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 574521007347 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 574521007348 ligand binding site [chemical binding]; other site 574521007349 NAD binding site [chemical binding]; other site 574521007350 catalytic site [active] 574521007351 homodimer interface [polypeptide binding]; other site 574521007352 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 574521007353 putative transporter; Provisional; Region: PRK12382 574521007354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521007355 putative substrate translocation pore; other site 574521007356 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 574521007357 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 574521007358 dimer interface [polypeptide binding]; other site 574521007359 active site 574521007360 Uncharacterized conserved protein [Function unknown]; Region: COG4121 574521007361 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 574521007362 YfcL protein; Region: YfcL; pfam08891 574521007363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 574521007364 hypothetical protein; Provisional; Region: PRK10621 574521007365 Predicted permeases [General function prediction only]; Region: COG0730 574521007366 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 574521007367 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 574521007368 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 574521007369 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 574521007370 Tetramer interface [polypeptide binding]; other site 574521007371 active site 574521007372 FMN-binding site [chemical binding]; other site 574521007373 HemK family putative methylases; Region: hemK_fam; TIGR00536 574521007374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521007375 S-adenosylmethionine binding site [chemical binding]; other site 574521007376 hypothetical protein; Provisional; Region: PRK04946 574521007377 Smr domain; Region: Smr; pfam01713 574521007378 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 574521007379 Fimbrial protein; Region: Fimbrial; cl01416 574521007380 Fimbrial protein; Region: Fimbrial; cl01416 574521007381 Fimbrial protein; Region: Fimbrial; cl01416 574521007382 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 574521007383 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 574521007384 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 574521007385 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 574521007386 PapC N-terminal domain; Region: PapC_N; pfam13954 574521007387 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 574521007388 PapC C-terminal domain; Region: PapC_C; pfam13953 574521007389 Fimbrial protein; Region: Fimbrial; cl01416 574521007390 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 574521007391 catalytic core [active] 574521007392 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 574521007393 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 574521007394 substrate binding site [chemical binding]; other site 574521007395 oxyanion hole (OAH) forming residues; other site 574521007396 trimer interface [polypeptide binding]; other site 574521007397 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 574521007398 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 574521007399 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 574521007400 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 574521007401 dimer interface [polypeptide binding]; other site 574521007402 active site 574521007403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 574521007404 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 574521007405 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 574521007406 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 574521007407 prophage E2348_PP8, P22-like 574521007408 integrase; Provisional; Region: PRK09692 574521007409 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 574521007410 active site 574521007411 Int/Topo IB signature motif; other site 574521007412 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 574521007413 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 574521007414 Baseplate J-like protein; Region: Baseplate_J; cl01294 574521007415 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 574521007416 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 574521007417 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 574521007418 virion protein; Provisional; Region: V; PHA02564 574521007419 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 574521007420 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 574521007421 Guanylyl transferase CofC like; Region: CofC; cl17472 574521007422 Superfamily II helicase, archaea-specific [General function prediction only]; Region: COG1202 574521007423 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 574521007424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 574521007425 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 574521007426 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 574521007427 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 574521007428 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 574521007429 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 574521007430 Terminase small subunit; Region: Terminase_2; pfam03592 574521007431 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 574521007432 N-acetyl-D-glucosamine binding site [chemical binding]; other site 574521007433 catalytic residue [active] 574521007434 phage holin, lambda family; Region: holin_lambda; TIGR01594 574521007435 HNH endonuclease; Region: HNH_3; pfam13392 574521007436 AP2 domain; Region: AP2; pfam00847 574521007437 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 574521007438 Endodeoxyribonuclease RusA; Region: RusA; cl01885 574521007439 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 574521007440 NinF protein; Region: NinF; pfam05810 574521007441 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 574521007442 NINE Protein; Region: NinE; pfam05322 574521007443 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 574521007444 NinB protein; Region: NinB; pfam05772 574521007445 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 574521007446 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 574521007447 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 574521007448 Walker A motif; other site 574521007449 ATP binding site [chemical binding]; other site 574521007450 Walker B motif; other site 574521007451 DNA binding loops [nucleotide binding] 574521007452 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 574521007453 Bacteriophage CII protein; Region: Phage_CII; pfam05269 574521007454 Cro; Region: Cro; pfam09048 574521007455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521007456 non-specific DNA binding site [nucleotide binding]; other site 574521007457 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 574521007458 salt bridge; other site 574521007459 sequence-specific DNA binding site [nucleotide binding]; other site 574521007460 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 574521007461 Catalytic site [active] 574521007462 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 574521007463 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 574521007464 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 574521007465 HNH endonuclease; Region: HNH_3; pfam13392 574521007466 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 574521007467 DNA-binding interface [nucleotide binding]; DNA binding site 574521007468 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 574521007469 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 574521007470 dimer interface [polypeptide binding]; other site 574521007471 ssDNA binding site [nucleotide binding]; other site 574521007472 tetramer (dimer of dimers) interface [polypeptide binding]; other site 574521007473 putative single-stranded DNA-binding protein; Region: PHA01740 574521007474 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 574521007475 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 574521007476 Protein of unknown function (DUF551); Region: DUF551; pfam04448 574521007477 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 574521007478 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 574521007479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521007480 putative substrate translocation pore; other site 574521007481 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 574521007482 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 574521007483 putative substrate binding site [chemical binding]; other site 574521007484 putative ATP binding site [chemical binding]; other site 574521007485 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 574521007486 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 574521007487 substrate binding [chemical binding]; other site 574521007488 active site 574521007489 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 574521007490 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521007491 DNA binding site [nucleotide binding] 574521007492 domain linker motif; other site 574521007493 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 574521007494 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 574521007495 putative dimerization interface [polypeptide binding]; other site 574521007496 putative ligand binding site [chemical binding]; other site 574521007497 pseudogene, C-ter part of transporter 574521007498 pseudogene, D-serine ammonia-lyase, truncated by frameshift mutation 574521007499 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 574521007500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521007501 putative substrate translocation pore; other site 574521007502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521007503 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 574521007504 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521007505 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521007506 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 574521007507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521007508 active site 574521007509 phosphorylation site [posttranslational modification] 574521007510 intermolecular recognition site; other site 574521007511 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521007512 DNA binding residues [nucleotide binding] 574521007513 dimerization interface [polypeptide binding]; other site 574521007514 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 574521007515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521007516 substrate binding pocket [chemical binding]; other site 574521007517 membrane-bound complex binding site; other site 574521007518 hinge residues; other site 574521007519 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521007520 substrate binding pocket [chemical binding]; other site 574521007521 membrane-bound complex binding site; other site 574521007522 hinge residues; other site 574521007523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521007524 dimer interface [polypeptide binding]; other site 574521007525 phosphorylation site [posttranslational modification] 574521007526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521007527 ATP binding site [chemical binding]; other site 574521007528 Mg2+ binding site [ion binding]; other site 574521007529 G-X-G motif; other site 574521007530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521007531 active site 574521007532 phosphorylation site [posttranslational modification] 574521007533 intermolecular recognition site; other site 574521007534 dimerization interface [polypeptide binding]; other site 574521007535 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 574521007536 putative binding surface; other site 574521007537 active site 574521007538 putative CoA-transferase; Provisional; Region: PRK11430 574521007539 CoA-transferase family III; Region: CoA_transf_3; pfam02515 574521007540 putative transporter YfdV; Provisional; Region: PRK09903 574521007541 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 574521007542 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 574521007543 PYR/PP interface [polypeptide binding]; other site 574521007544 dimer interface [polypeptide binding]; other site 574521007545 TPP binding site [chemical binding]; other site 574521007546 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 574521007547 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 574521007548 TPP-binding site; other site 574521007549 dimer interface [polypeptide binding]; other site 574521007550 formyl-coenzyme A transferase; Provisional; Region: PRK05398 574521007551 CoA-transferase family III; Region: CoA_transf_3; pfam02515 574521007552 hypothetical protein; Provisional; Region: PRK10316 574521007553 YfdX protein; Region: YfdX; pfam10938 574521007554 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 574521007555 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 574521007556 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 574521007557 putative acyl-acceptor binding pocket; other site 574521007558 aminotransferase; Validated; Region: PRK08175 574521007559 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 574521007560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521007561 homodimer interface [polypeptide binding]; other site 574521007562 catalytic residue [active] 574521007563 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 574521007564 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 574521007565 GAF domain; Region: GAF; cl17456 574521007566 Histidine kinase; Region: His_kinase; pfam06580 574521007567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521007568 ATP binding site [chemical binding]; other site 574521007569 Mg2+ binding site [ion binding]; other site 574521007570 G-X-G motif; other site 574521007571 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 574521007572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521007573 active site 574521007574 phosphorylation site [posttranslational modification] 574521007575 intermolecular recognition site; other site 574521007576 dimerization interface [polypeptide binding]; other site 574521007577 LytTr DNA-binding domain; Region: LytTR; pfam04397 574521007578 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 574521007579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521007580 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 574521007581 dimerization domain swap beta strand [polypeptide binding]; other site 574521007582 regulatory protein interface [polypeptide binding]; other site 574521007583 active site 574521007584 regulatory phosphorylation site [posttranslational modification]; other site 574521007585 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 574521007586 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 574521007587 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 574521007588 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 574521007589 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 574521007590 active site 574521007591 phosphorylation site [posttranslational modification] 574521007592 exoaminopeptidase; Provisional; Region: PRK09961 574521007593 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 574521007594 oligomer interface [polypeptide binding]; other site 574521007595 active site 574521007596 metal binding site [ion binding]; metal-binding site 574521007597 aminopeptidase; Provisional; Region: PRK09795 574521007598 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 574521007599 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 574521007600 active site 574521007601 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 574521007602 pseudogene, enzyme IIB component of PTS, truncated by premature stop codon 574521007603 glucokinase, proteobacterial type; Region: glk; TIGR00749 574521007604 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 574521007605 nucleotide binding site [chemical binding]; other site 574521007606 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 574521007607 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 574521007608 Cl- selectivity filter; other site 574521007609 Cl- binding residues [ion binding]; other site 574521007610 pore gating glutamate residue; other site 574521007611 dimer interface [polypeptide binding]; other site 574521007612 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 574521007613 manganese transport protein MntH; Reviewed; Region: PRK00701 574521007614 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 574521007615 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 574521007616 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 574521007617 Nucleoside recognition; Region: Gate; pfam07670 574521007618 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 574521007619 MASE1; Region: MASE1; pfam05231 574521007620 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 574521007621 diguanylate cyclase; Region: GGDEF; smart00267 574521007622 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521007623 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 574521007624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521007625 salt bridge; other site 574521007626 non-specific DNA binding site [nucleotide binding]; other site 574521007627 sequence-specific DNA binding site [nucleotide binding]; other site 574521007628 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 574521007629 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 574521007630 active site 574521007631 HIGH motif; other site 574521007632 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 574521007633 active site 574521007634 KMSKS motif; other site 574521007635 pseudogene, DNA-binding transcriptional activator, truncated by frameshift mutation 574521007636 nucleoside transporter; Region: 2A0110; TIGR00889 574521007637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521007638 putative substrate translocation pore; other site 574521007639 purine nucleoside phosphorylase; Provisional; Region: PRK08202 574521007640 hypothetical protein; Provisional; Region: PRK11528 574521007641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 574521007642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521007643 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 574521007644 putative dimerization interface [polypeptide binding]; other site 574521007645 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 574521007646 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 574521007647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 574521007648 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 574521007649 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 574521007650 nucleotide binding pocket [chemical binding]; other site 574521007651 K-X-D-G motif; other site 574521007652 catalytic site [active] 574521007653 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 574521007654 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 574521007655 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 574521007656 Dimer interface [polypeptide binding]; other site 574521007657 BRCT sequence motif; other site 574521007658 cell division protein ZipA; Provisional; Region: PRK03427 574521007659 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 574521007660 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 574521007661 FtsZ protein binding site [polypeptide binding]; other site 574521007662 putative sulfate transport protein CysZ; Validated; Region: PRK04949 574521007663 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 574521007664 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 574521007665 dimer interface [polypeptide binding]; other site 574521007666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521007667 catalytic residue [active] 574521007668 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 574521007669 dimerization domain swap beta strand [polypeptide binding]; other site 574521007670 regulatory protein interface [polypeptide binding]; other site 574521007671 active site 574521007672 regulatory phosphorylation site [posttranslational modification]; other site 574521007673 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 574521007674 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 574521007675 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 574521007676 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 574521007677 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 574521007678 HPr interaction site; other site 574521007679 glycerol kinase (GK) interaction site [polypeptide binding]; other site 574521007680 active site 574521007681 phosphorylation site [posttranslational modification] 574521007682 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 574521007683 dimer interface [polypeptide binding]; other site 574521007684 pyridoxamine kinase; Validated; Region: PRK05756 574521007685 pyridoxal binding site [chemical binding]; other site 574521007686 ATP binding site [chemical binding]; other site 574521007687 hypothetical protein; Provisional; Region: PRK10318 574521007688 cysteine synthase B; Region: cysM; TIGR01138 574521007689 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 574521007690 dimer interface [polypeptide binding]; other site 574521007691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521007692 catalytic residue [active] 574521007693 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 574521007694 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 574521007695 Walker A/P-loop; other site 574521007696 ATP binding site [chemical binding]; other site 574521007697 Q-loop/lid; other site 574521007698 ABC transporter signature motif; other site 574521007699 Walker B; other site 574521007700 D-loop; other site 574521007701 H-loop/switch region; other site 574521007702 TOBE-like domain; Region: TOBE_3; pfam12857 574521007703 sulfate transport protein; Provisional; Region: cysT; CHL00187 574521007704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521007705 dimer interface [polypeptide binding]; other site 574521007706 conserved gate region; other site 574521007707 putative PBP binding loops; other site 574521007708 ABC-ATPase subunit interface; other site 574521007709 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 574521007710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521007711 dimer interface [polypeptide binding]; other site 574521007712 conserved gate region; other site 574521007713 putative PBP binding loops; other site 574521007714 ABC-ATPase subunit interface; other site 574521007715 thiosulfate transporter subunit; Provisional; Region: PRK10852 574521007716 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 574521007717 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521007718 short chain dehydrogenase; Provisional; Region: PRK08226 574521007719 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 574521007720 NAD binding site [chemical binding]; other site 574521007721 homotetramer interface [polypeptide binding]; other site 574521007722 homodimer interface [polypeptide binding]; other site 574521007723 active site 574521007724 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 574521007725 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 574521007726 putative active site [active] 574521007727 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 574521007728 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 574521007729 active site turn [active] 574521007730 phosphorylation site [posttranslational modification] 574521007731 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 574521007732 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 574521007733 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 574521007734 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 574521007735 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 574521007736 putative acetyltransferase; Provisional; Region: PRK03624 574521007737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521007738 Coenzyme A binding pocket [chemical binding]; other site 574521007739 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 574521007740 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 574521007741 active site 574521007742 metal binding site [ion binding]; metal-binding site 574521007743 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 574521007744 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 574521007745 Uncharacterized conserved protein [Function unknown]; Region: COG4279 574521007746 SNF2 Helicase protein; Region: DUF3670; pfam12419 574521007747 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 574521007748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 574521007749 ATP binding site [chemical binding]; other site 574521007750 putative Mg++ binding site [ion binding]; other site 574521007751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521007752 nucleotide binding region [chemical binding]; other site 574521007753 ATP-binding site [chemical binding]; other site 574521007754 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 574521007755 transcriptional regulator EutR; Provisional; Region: PRK10130 574521007756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521007757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521007758 carboxysome structural protein EutK; Provisional; Region: PRK15466 574521007759 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 574521007760 Hexamer interface [polypeptide binding]; other site 574521007761 Hexagonal pore residue; other site 574521007762 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 574521007763 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 574521007764 putative hexamer interface [polypeptide binding]; other site 574521007765 putative hexagonal pore; other site 574521007766 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 574521007767 putative hexamer interface [polypeptide binding]; other site 574521007768 putative hexagonal pore; other site 574521007769 pseudogene, ethanolamine ammonia-lyase, small subunit (light chain), disrupted by Mu-like phage integration 574521007770 prophage E2348_PP9, Mu-like 574521007771 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 574521007772 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 574521007773 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 574521007774 Integrase core domain; Region: rve; pfam00665 574521007775 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 574521007776 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 574521007777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 574521007778 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 574521007779 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 574521007780 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 574521007781 protease3; Provisional; Region: PRK15101 574521007782 Mor transcription activator family; Region: Mor; cl02360 574521007783 Protein of unknown function (DUF754); Region: DUF754; pfam05449 574521007784 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 574521007785 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 574521007786 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 574521007787 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 574521007788 DNA methylase; Region: N6_N4_Mtase; cl17433 574521007789 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 574521007790 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 574521007791 Protein of unknown function (DUF935); Region: DUF935; pfam06074 574521007792 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 574521007793 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 574521007794 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 574521007795 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 574521007796 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 574521007797 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 574521007798 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 574521007799 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 574521007800 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 574521007801 Domain of unknown function (DUF1834); Region: DUF1834; pfam08873 574521007802 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 574521007803 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 574521007804 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 574521007805 Coenzyme A transferase; Region: CoA_trans; cl17247 574521007806 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 574521007807 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 574521007808 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 574521007809 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 574521007810 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 574521007811 Phage protein GP46; Region: GP46; cl01814 574521007812 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 574521007813 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 574521007814 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 574521007815 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 574521007816 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 574521007817 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 574521007818 pseudogene, reactivating factor for ethanolamine ammonia lyase, disrupted by ISEc13 574521007819 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521007820 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 574521007821 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 574521007822 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 574521007823 active site 574521007824 metal binding site [ion binding]; metal-binding site 574521007825 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 574521007826 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 574521007827 nucleotide binding site [chemical binding]; other site 574521007828 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 574521007829 putative catalytic cysteine [active] 574521007830 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 574521007831 Hexamer/Pentamer interface [polypeptide binding]; other site 574521007832 central pore; other site 574521007833 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 574521007834 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 574521007835 Hexamer interface [polypeptide binding]; other site 574521007836 Putative hexagonal pore residue; other site 574521007837 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 574521007838 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 574521007839 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 574521007840 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 574521007841 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 574521007842 G1 box; other site 574521007843 GTP/Mg2+ binding site [chemical binding]; other site 574521007844 G2 box; other site 574521007845 Switch I region; other site 574521007846 G3 box; other site 574521007847 Switch II region; other site 574521007848 G4 box; other site 574521007849 G5 box; other site 574521007850 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 574521007851 putative hexamer interface [polypeptide binding]; other site 574521007852 putative hexagonal pore; other site 574521007853 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 574521007854 Malic enzyme, N-terminal domain; Region: malic; pfam00390 574521007855 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 574521007856 putative NAD(P) binding site [chemical binding]; other site 574521007857 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 574521007858 transaldolase-like protein; Provisional; Region: PTZ00411 574521007859 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 574521007860 active site 574521007861 dimer interface [polypeptide binding]; other site 574521007862 catalytic residue [active] 574521007863 transketolase; Reviewed; Region: PRK12753 574521007864 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 574521007865 TPP-binding site [chemical binding]; other site 574521007866 dimer interface [polypeptide binding]; other site 574521007867 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 574521007868 PYR/PP interface [polypeptide binding]; other site 574521007869 dimer interface [polypeptide binding]; other site 574521007870 TPP binding site [chemical binding]; other site 574521007871 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 574521007872 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 574521007873 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 574521007874 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 574521007875 dimer interface [polypeptide binding]; other site 574521007876 ADP-ribose binding site [chemical binding]; other site 574521007877 active site 574521007878 nudix motif; other site 574521007879 metal binding site [ion binding]; metal-binding site 574521007880 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 574521007881 4Fe-4S binding domain; Region: Fer4; pfam00037 574521007882 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 574521007883 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521007884 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 574521007885 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 574521007886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 574521007887 dimerization interface [polypeptide binding]; other site 574521007888 Histidine kinase; Region: HisKA_3; pfam07730 574521007889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521007890 ATP binding site [chemical binding]; other site 574521007891 Mg2+ binding site [ion binding]; other site 574521007892 G-X-G motif; other site 574521007893 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 574521007894 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 574521007895 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 574521007896 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 574521007897 Autotransporter beta-domain; Region: Autotransporter; smart00869 574521007898 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 574521007899 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 574521007900 Protein export membrane protein; Region: SecD_SecF; cl14618 574521007901 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 574521007902 ArsC family; Region: ArsC; pfam03960 574521007903 putative catalytic residues [active] 574521007904 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 574521007905 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 574521007906 metal binding site [ion binding]; metal-binding site 574521007907 dimer interface [polypeptide binding]; other site 574521007908 hypothetical protein; Provisional; Region: PRK13664 574521007909 putative hydrolase; Provisional; Region: PRK11460 574521007910 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 574521007911 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 574521007912 Helicase; Region: Helicase_RecD; pfam05127 574521007913 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 574521007914 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 574521007915 Predicted metalloprotease [General function prediction only]; Region: COG2321 574521007916 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 574521007917 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 574521007918 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 574521007919 ATP binding site [chemical binding]; other site 574521007920 active site 574521007921 substrate binding site [chemical binding]; other site 574521007922 lipoprotein; Provisional; Region: PRK11679 574521007923 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 574521007924 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 574521007925 dihydrodipicolinate synthase; Region: dapA; TIGR00674 574521007926 dimer interface [polypeptide binding]; other site 574521007927 active site 574521007928 catalytic residue [active] 574521007929 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 574521007930 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 574521007931 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 574521007932 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 574521007933 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 574521007934 catalytic triad [active] 574521007935 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 574521007936 Domain of unknown function DUF20; Region: UPF0118; pfam01594 574521007937 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 574521007938 Peptidase family M48; Region: Peptidase_M48; cl12018 574521007939 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 574521007940 ArsC family; Region: ArsC; pfam03960 574521007941 catalytic residues [active] 574521007942 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 574521007943 DNA replication initiation factor; Provisional; Region: PRK08084 574521007944 uracil transporter; Provisional; Region: PRK10720 574521007945 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 574521007946 active site 574521007947 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 574521007948 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 574521007949 dimerization interface [polypeptide binding]; other site 574521007950 putative ATP binding site [chemical binding]; other site 574521007951 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 574521007952 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 574521007953 active site 574521007954 substrate binding site [chemical binding]; other site 574521007955 cosubstrate binding site; other site 574521007956 catalytic site [active] 574521007957 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 574521007958 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 574521007959 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 574521007960 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 574521007961 domain interface [polypeptide binding]; other site 574521007962 active site 574521007963 catalytic site [active] 574521007964 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 574521007965 putative active site [active] 574521007966 catalytic site [active] 574521007967 exopolyphosphatase; Provisional; Region: PRK10854 574521007968 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 574521007969 MASE1; Region: MASE1; pfam05231 574521007970 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 574521007971 diguanylate cyclase; Region: GGDEF; smart00267 574521007972 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521007973 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 574521007974 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 574521007975 prophage E2348_PP10, epsilon15-like 574521007976 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 574521007977 Predicted chitinase [General function prediction only]; Region: COG3179 574521007978 catalytic residue [active] 574521007979 Protein of unknown function (DUF754); Region: DUF754; pfam05449 574521007980 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 574521007981 hypothetical protein; Provisional; Region: PHA02515 574521007982 structural protein; Region: PHA01972 574521007983 virion protein; Provisional; Region: V; PHA02564 574521007984 hypothetical protein; Region: PHA01733 574521007985 hypothetical protein; Region: PHA00661 574521007986 hypothetical protein; Region: PHA00662 574521007987 hypothetical protein; Region: PHA00669 574521007988 hypothetical protein; Region: PHA00664 574521007989 major capsid protein; Region: PHA00665 574521007990 putative protease; Region: PHA00666 574521007991 hypothetical protein; Region: PHA00670 574521007992 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 574521007993 Terminase small subunit; Region: Terminase_2; pfam03592 574521007994 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 574521007995 Replication protein P; Region: Phage_lambda_P; pfam06992 574521007996 Pyocin large subunit [General function prediction only]; Region: COG5529 574521007997 Helix-turn-helix domain; Region: HTH_36; pfam13730 574521007998 primosomal protein DnaI; Provisional; Region: PRK02854 574521007999 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521008000 salt bridge; other site 574521008001 non-specific DNA binding site [nucleotide binding]; other site 574521008002 sequence-specific DNA binding site [nucleotide binding]; other site 574521008003 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 574521008004 RecT family; Region: RecT; pfam03837 574521008005 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 574521008006 PerC transcriptional activator; Region: PerC; pfam06069 574521008007 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 574521008008 MT-A70; Region: MT-A70; cl01947 574521008009 integrase; Provisional; Region: PRK09692 574521008010 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 574521008011 active site 574521008012 Int/Topo IB signature motif; other site 574521008013 GMP synthase; Reviewed; Region: guaA; PRK00074 574521008014 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 574521008015 AMP/PPi binding site [chemical binding]; other site 574521008016 candidate oxyanion hole; other site 574521008017 catalytic triad [active] 574521008018 potential glutamine specificity residues [chemical binding]; other site 574521008019 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 574521008020 ATP Binding subdomain [chemical binding]; other site 574521008021 Ligand Binding sites [chemical binding]; other site 574521008022 Dimerization subdomain; other site 574521008023 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 574521008024 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 574521008025 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 574521008026 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 574521008027 active site 574521008028 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 574521008029 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 574521008030 generic binding surface II; other site 574521008031 generic binding surface I; other site 574521008032 integrative element E2348_IE4 574521008033 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 574521008034 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 574521008035 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 574521008036 intimin-like protein SinH; Provisional; Region: PRK15318 574521008037 intimin-like protein SinH; Provisional; Region: PRK15318 574521008038 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 574521008039 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 574521008040 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 574521008041 active site 574521008042 NTP binding site [chemical binding]; other site 574521008043 metal binding triad [ion binding]; metal-binding site 574521008044 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 574521008045 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 574521008046 integrase; Provisional; Region: PRK09692 574521008047 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 574521008048 active site 574521008049 Int/Topo IB signature motif; other site 574521008050 GTP-binding protein Der; Reviewed; Region: PRK00093 574521008051 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 574521008052 G1 box; other site 574521008053 GTP/Mg2+ binding site [chemical binding]; other site 574521008054 Switch I region; other site 574521008055 G2 box; other site 574521008056 Switch II region; other site 574521008057 G3 box; other site 574521008058 G4 box; other site 574521008059 G5 box; other site 574521008060 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 574521008061 G1 box; other site 574521008062 GTP/Mg2+ binding site [chemical binding]; other site 574521008063 Switch I region; other site 574521008064 G2 box; other site 574521008065 G3 box; other site 574521008066 Switch II region; other site 574521008067 G4 box; other site 574521008068 G5 box; other site 574521008069 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 574521008070 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 574521008071 Trp docking motif [polypeptide binding]; other site 574521008072 active site 574521008073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 574521008074 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 574521008075 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 574521008076 dimer interface [polypeptide binding]; other site 574521008077 motif 1; other site 574521008078 active site 574521008079 motif 2; other site 574521008080 motif 3; other site 574521008081 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 574521008082 anticodon binding site; other site 574521008083 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 574521008084 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 574521008085 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 574521008086 cytoskeletal protein RodZ; Provisional; Region: PRK10856 574521008087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521008088 non-specific DNA binding site [nucleotide binding]; other site 574521008089 salt bridge; other site 574521008090 sequence-specific DNA binding site [nucleotide binding]; other site 574521008091 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 574521008092 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 574521008093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521008094 FeS/SAM binding site; other site 574521008095 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 574521008096 active site 574521008097 multimer interface [polypeptide binding]; other site 574521008098 penicillin-binding protein 1C; Provisional; Region: PRK11240 574521008099 Transglycosylase; Region: Transgly; pfam00912 574521008100 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 574521008101 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 574521008102 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 574521008103 MG2 domain; Region: A2M_N; pfam01835 574521008104 Alpha-2-macroglobulin family; Region: A2M; pfam00207 574521008105 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 574521008106 surface patch; other site 574521008107 thioester region; other site 574521008108 specificity defining residues; other site 574521008109 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 574521008110 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 574521008111 active site residue [active] 574521008112 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 574521008113 active site residue [active] 574521008114 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 574521008115 aminopeptidase B; Provisional; Region: PRK05015 574521008116 Peptidase; Region: DUF3663; pfam12404 574521008117 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 574521008118 interface (dimer of trimers) [polypeptide binding]; other site 574521008119 Substrate-binding/catalytic site; other site 574521008120 Zn-binding sites [ion binding]; other site 574521008121 hypothetical protein; Provisional; Region: PRK10721 574521008122 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 574521008123 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 574521008124 catalytic loop [active] 574521008125 iron binding site [ion binding]; other site 574521008126 chaperone protein HscA; Provisional; Region: hscA; PRK05183 574521008127 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 574521008128 nucleotide binding site [chemical binding]; other site 574521008129 putative NEF/HSP70 interaction site [polypeptide binding]; other site 574521008130 SBD interface [polypeptide binding]; other site 574521008131 co-chaperone HscB; Provisional; Region: hscB; PRK05014 574521008132 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 574521008133 HSP70 interaction site [polypeptide binding]; other site 574521008134 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 574521008135 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 574521008136 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 574521008137 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 574521008138 trimerization site [polypeptide binding]; other site 574521008139 active site 574521008140 cysteine desulfurase; Provisional; Region: PRK14012 574521008141 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 574521008142 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 574521008143 catalytic residue [active] 574521008144 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 574521008145 Rrf2 family protein; Region: rrf2_super; TIGR00738 574521008146 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 574521008147 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 574521008148 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 574521008149 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 574521008150 active site 574521008151 dimerization interface [polypeptide binding]; other site 574521008152 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 574521008153 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 574521008154 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 574521008155 PRD domain; Region: PRD; pfam00874 574521008156 PRD domain; Region: PRD; pfam00874 574521008157 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 574521008158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521008159 putative substrate translocation pore; other site 574521008160 Predicted membrane protein [Function unknown]; Region: COG2259 574521008161 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 574521008162 active site 574521008163 catalytic residues [active] 574521008164 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 574521008165 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 574521008166 putative NAD(P) binding site [chemical binding]; other site 574521008167 catalytic Zn binding site [ion binding]; other site 574521008168 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 574521008169 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 574521008170 TM-ABC transporter signature motif; other site 574521008171 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 574521008172 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 574521008173 Walker A/P-loop; other site 574521008174 ATP binding site [chemical binding]; other site 574521008175 Q-loop/lid; other site 574521008176 ABC transporter signature motif; other site 574521008177 Walker B; other site 574521008178 D-loop; other site 574521008179 H-loop/switch region; other site 574521008180 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 574521008181 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 574521008182 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 574521008183 ligand binding site [chemical binding]; other site 574521008184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 574521008185 TPR motif; other site 574521008186 binding surface 574521008187 TPR repeat; Region: TPR_11; pfam13414 574521008188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 574521008189 TPR motif; other site 574521008190 binding surface 574521008191 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 574521008192 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 574521008193 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 574521008194 nucleotide binding site [chemical binding]; other site 574521008195 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 574521008196 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 574521008197 dimer interface [polypeptide binding]; other site 574521008198 active site 574521008199 glycine-pyridoxal phosphate binding site [chemical binding]; other site 574521008200 folate binding site [chemical binding]; other site 574521008201 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 574521008202 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 574521008203 heme-binding site [chemical binding]; other site 574521008204 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 574521008205 FAD binding pocket [chemical binding]; other site 574521008206 FAD binding motif [chemical binding]; other site 574521008207 phosphate binding motif [ion binding]; other site 574521008208 beta-alpha-beta structure motif; other site 574521008209 NAD binding pocket [chemical binding]; other site 574521008210 Heme binding pocket [chemical binding]; other site 574521008211 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 574521008212 Nitrogen regulatory protein P-II; Region: P-II; smart00938 574521008213 response regulator GlrR; Provisional; Region: PRK15115 574521008214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521008215 active site 574521008216 phosphorylation site [posttranslational modification] 574521008217 intermolecular recognition site; other site 574521008218 dimerization interface [polypeptide binding]; other site 574521008219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521008220 Walker A motif; other site 574521008221 ATP binding site [chemical binding]; other site 574521008222 Walker B motif; other site 574521008223 arginine finger; other site 574521008224 hypothetical protein; Provisional; Region: PRK10722 574521008225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 574521008226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521008227 dimer interface [polypeptide binding]; other site 574521008228 phosphorylation site [posttranslational modification] 574521008229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521008230 ATP binding site [chemical binding]; other site 574521008231 Mg2+ binding site [ion binding]; other site 574521008232 G-X-G motif; other site 574521008233 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 574521008234 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 574521008235 dimerization interface [polypeptide binding]; other site 574521008236 ATP binding site [chemical binding]; other site 574521008237 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 574521008238 dimerization interface [polypeptide binding]; other site 574521008239 ATP binding site [chemical binding]; other site 574521008240 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 574521008241 putative active site [active] 574521008242 catalytic triad [active] 574521008243 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 574521008244 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521008245 substrate binding pocket [chemical binding]; other site 574521008246 membrane-bound complex binding site; other site 574521008247 hinge residues; other site 574521008248 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 574521008249 N-acetyl-D-glucosamine binding site [chemical binding]; other site 574521008250 catalytic residue [active] 574521008251 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 574521008252 nucleoside/Zn binding site; other site 574521008253 dimer interface [polypeptide binding]; other site 574521008254 catalytic motif [active] 574521008255 hypothetical protein; Provisional; Region: PRK11590 574521008256 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 574521008257 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 574521008258 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 574521008259 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 574521008260 putative active site [active] 574521008261 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 574521008262 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 574521008263 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 574521008264 active site 574521008265 hydrophilic channel; other site 574521008266 dimerization interface [polypeptide binding]; other site 574521008267 catalytic residues [active] 574521008268 active site lid [active] 574521008269 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 574521008270 Recombination protein O N terminal; Region: RecO_N; pfam11967 574521008271 Recombination protein O C terminal; Region: RecO_C; pfam02565 574521008272 GTPase Era; Reviewed; Region: era; PRK00089 574521008273 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 574521008274 G1 box; other site 574521008275 GTP/Mg2+ binding site [chemical binding]; other site 574521008276 Switch I region; other site 574521008277 G2 box; other site 574521008278 Switch II region; other site 574521008279 G3 box; other site 574521008280 G4 box; other site 574521008281 G5 box; other site 574521008282 KH domain; Region: KH_2; pfam07650 574521008283 ribonuclease III; Reviewed; Region: rnc; PRK00102 574521008284 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 574521008285 dimerization interface [polypeptide binding]; other site 574521008286 active site 574521008287 metal binding site [ion binding]; metal-binding site 574521008288 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 574521008289 dsRNA binding site [nucleotide binding]; other site 574521008290 signal peptidase I; Provisional; Region: PRK10861 574521008291 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 574521008292 Catalytic site [active] 574521008293 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 574521008294 GTP-binding protein LepA; Provisional; Region: PRK05433 574521008295 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 574521008296 G1 box; other site 574521008297 putative GEF interaction site [polypeptide binding]; other site 574521008298 GTP/Mg2+ binding site [chemical binding]; other site 574521008299 Switch I region; other site 574521008300 G2 box; other site 574521008301 G3 box; other site 574521008302 Switch II region; other site 574521008303 G4 box; other site 574521008304 G5 box; other site 574521008305 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 574521008306 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 574521008307 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 574521008308 SoxR reducing system protein RseC; Provisional; Region: PRK10862 574521008309 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 574521008310 anti-sigma E factor; Provisional; Region: rseB; PRK09455 574521008311 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 574521008312 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 574521008313 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 574521008314 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 574521008315 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 574521008316 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 574521008317 DNA binding residues [nucleotide binding] 574521008318 L-aspartate oxidase; Provisional; Region: PRK09077 574521008319 L-aspartate oxidase; Provisional; Region: PRK06175 574521008320 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 574521008321 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 574521008322 Methyltransferase domain; Region: Methyltransf_26; pfam13659 574521008323 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 574521008324 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 574521008325 ATP binding site [chemical binding]; other site 574521008326 Mg++ binding site [ion binding]; other site 574521008327 motif III; other site 574521008328 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521008329 nucleotide binding region [chemical binding]; other site 574521008330 ATP-binding site [chemical binding]; other site 574521008331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 574521008332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521008333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 574521008334 dimerization interface [polypeptide binding]; other site 574521008335 pseudogene, neutral amino-acid efflux system, truncated by frameshift mutation 574521008336 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 574521008337 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 574521008338 ligand binding site [chemical binding]; other site 574521008339 active site 574521008340 UGI interface [polypeptide binding]; other site 574521008341 catalytic site [active] 574521008342 putative methyltransferase; Provisional; Region: PRK10864 574521008343 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 574521008344 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 574521008345 thioredoxin 2; Provisional; Region: PRK10996 574521008346 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 574521008347 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 574521008348 catalytic residues [active] 574521008349 Uncharacterized conserved protein [Function unknown]; Region: COG3148 574521008350 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 574521008351 CoA binding domain; Region: CoA_binding_2; pfam13380 574521008352 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 574521008353 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 574521008354 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 574521008355 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 574521008356 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 574521008357 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 574521008358 domain interface [polypeptide binding]; other site 574521008359 putative active site [active] 574521008360 catalytic site [active] 574521008361 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 574521008362 domain interface [polypeptide binding]; other site 574521008363 putative active site [active] 574521008364 catalytic site [active] 574521008365 lipoprotein; Provisional; Region: PRK10759 574521008366 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 574521008367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521008368 putative substrate translocation pore; other site 574521008369 pseudogene, transposase, truncated by multiple mutations 574521008370 protein disaggregation chaperone; Provisional; Region: PRK10865 574521008371 Clp amino terminal domain; Region: Clp_N; pfam02861 574521008372 Clp amino terminal domain; Region: Clp_N; pfam02861 574521008373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521008374 Walker A motif; other site 574521008375 ATP binding site [chemical binding]; other site 574521008376 Walker B motif; other site 574521008377 arginine finger; other site 574521008378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521008379 Walker A motif; other site 574521008380 ATP binding site [chemical binding]; other site 574521008381 Walker B motif; other site 574521008382 arginine finger; other site 574521008383 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 574521008384 hypothetical protein; Provisional; Region: PRK10723 574521008385 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 574521008386 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 574521008387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 574521008388 RNA binding surface [nucleotide binding]; other site 574521008389 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 574521008390 active site 574521008391 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 574521008392 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 574521008393 pseudogene, transposase of IS4, fragmented by multiple mutations 574521008394 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 574521008395 30S subunit binding site; other site 574521008396 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 574521008397 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 574521008398 Prephenate dehydratase; Region: PDT; pfam00800 574521008399 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 574521008400 putative L-Phe binding site [chemical binding]; other site 574521008401 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 574521008402 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 574521008403 prephenate dehydrogenase; Validated; Region: PRK08507 574521008404 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 574521008405 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 574521008406 lipoprotein; Provisional; Region: PRK11443 574521008407 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 574521008408 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 574521008409 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 574521008410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 574521008411 metal binding site [ion binding]; metal-binding site 574521008412 active site 574521008413 I-site; other site 574521008414 putative outer membrane lipoprotein; Provisional; Region: PRK09967 574521008415 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 574521008416 ligand binding site [chemical binding]; other site 574521008417 prophage E2348_PP11, P2-like 574521008418 E2348_PP11; pseudogene, integrase, C-ter part 574521008419 E2348_PP11; pseudogene, C-ter part of tail fiber protein 574521008420 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 574521008421 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 574521008422 E2348_PP11; pseudogene, C-ter part of tail fiber protein 574521008423 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 574521008424 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 574521008425 catalytic residues [active] 574521008426 catalytic nucleophile [active] 574521008427 Presynaptic Site I dimer interface [polypeptide binding]; other site 574521008428 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 574521008429 Synaptic Flat tetramer interface [polypeptide binding]; other site 574521008430 Synaptic Site I dimer interface [polypeptide binding]; other site 574521008431 DNA binding site [nucleotide binding] 574521008432 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 574521008433 DNA-binding interface [nucleotide binding]; DNA binding site 574521008434 major tail sheath protein; Provisional; Region: FI; PHA02560 574521008435 major tail tube protein; Provisional; Region: FII; PHA02600 574521008436 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 574521008437 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 574521008438 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 574521008439 tail protein; Provisional; Region: D; PHA02561 574521008440 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 574521008441 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 574521008442 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 574521008443 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 574521008444 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 574521008445 RimM N-terminal domain; Region: RimM; pfam01782 574521008446 PRC-barrel domain; Region: PRC; pfam05239 574521008447 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 574521008448 signal recognition particle protein; Provisional; Region: PRK10867 574521008449 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 574521008450 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 574521008451 P loop; other site 574521008452 GTP binding site [chemical binding]; other site 574521008453 Signal peptide binding domain; Region: SRP_SPB; pfam02978 574521008454 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 574521008455 hypothetical protein; Provisional; Region: PRK11573 574521008456 Domain of unknown function DUF21; Region: DUF21; pfam01595 574521008457 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 574521008458 Transporter associated domain; Region: CorC_HlyC; smart01091 574521008459 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 574521008460 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 574521008461 dimer interface [polypeptide binding]; other site 574521008462 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 574521008463 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 574521008464 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 574521008465 recombination and repair protein; Provisional; Region: PRK10869 574521008466 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 574521008467 Walker A/P-loop; other site 574521008468 ATP binding site [chemical binding]; other site 574521008469 Q-loop/lid; other site 574521008470 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 574521008471 Q-loop/lid; other site 574521008472 ABC transporter signature motif; other site 574521008473 Walker B; other site 574521008474 D-loop; other site 574521008475 H-loop/switch region; other site 574521008476 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 574521008477 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 574521008478 hypothetical protein; Validated; Region: PRK01777 574521008479 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 574521008480 putative coenzyme Q binding site [chemical binding]; other site 574521008481 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 574521008482 SmpB-tmRNA interface; other site 574521008483 integrative element E2348_IE5 574521008484 E2348_IE5; pseudogene, transposase Orf2 of IS100, truncated by premature stop codon 574521008486 E2348_IE5; pseudogene, integrase, truncated 574521008487 E2348_IE5; pseudogene, transposase, fragmented by multiple mutations 574521008488 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 574521008489 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 574521008490 hydrophobic ligand binding site; other site 574521008491 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 574521008492 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 574521008493 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 574521008494 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 574521008495 Autotransporter beta-domain; Region: Autotransporter; pfam03797 574521008496 EspG protein; Region: EspG; pfam06872 574521008497 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 574521008498 substrate binding pocket [chemical binding]; other site 574521008499 active site 574521008500 iron coordination sites [ion binding]; other site 574521008501 Predicted dehydrogenase [General function prediction only]; Region: COG0579 574521008502 hydroxyglutarate oxidase; Provisional; Region: PRK11728 574521008503 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 574521008504 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 574521008505 tetramerization interface [polypeptide binding]; other site 574521008506 NAD(P) binding site [chemical binding]; other site 574521008507 catalytic residues [active] 574521008508 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 574521008509 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 574521008510 inhibitor-cofactor binding pocket; inhibition site 574521008511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521008512 catalytic residue [active] 574521008513 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 574521008514 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 574521008515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521008516 DNA-binding site [nucleotide binding]; DNA binding site 574521008517 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 574521008518 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 574521008519 bacterial OsmY and nodulation domain; Region: BON; smart00749 574521008520 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 574521008521 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 574521008522 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 574521008523 dimerization interface [polypeptide binding]; other site 574521008524 putative DNA binding site [nucleotide binding]; other site 574521008525 Transcriptional regulators [Transcription]; Region: MarR; COG1846 574521008526 putative Zn2+ binding site [ion binding]; other site 574521008527 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 574521008528 active site residue [active] 574521008529 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 574521008530 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 574521008531 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 574521008532 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 574521008533 hypothetical protein; Provisional; Region: PRK10556 574521008534 hypothetical protein; Provisional; Region: PRK10132 574521008535 pseudogene, transcriptional regulator, truncated by frameshift mutation 574521008536 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 574521008537 Uncharacterized conserved protein [Function unknown]; Region: COG2128 574521008538 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 574521008539 catalytic residues [active] 574521008540 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 574521008541 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 574521008542 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 574521008543 Class I ribonucleotide reductase; Region: RNR_I; cd01679 574521008544 active site 574521008545 dimer interface [polypeptide binding]; other site 574521008546 catalytic residues [active] 574521008547 effector binding site; other site 574521008548 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 574521008549 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 574521008550 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 574521008551 dimer interface [polypeptide binding]; other site 574521008552 putative radical transfer pathway; other site 574521008553 diiron center [ion binding]; other site 574521008554 tyrosyl radical; other site 574521008555 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 574521008556 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 574521008557 Walker A/P-loop; other site 574521008558 ATP binding site [chemical binding]; other site 574521008559 Q-loop/lid; other site 574521008560 ABC transporter signature motif; other site 574521008561 Walker B; other site 574521008562 D-loop; other site 574521008563 H-loop/switch region; other site 574521008564 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 574521008565 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 574521008566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521008567 dimer interface [polypeptide binding]; other site 574521008568 conserved gate region; other site 574521008569 putative PBP binding loops; other site 574521008570 ABC-ATPase subunit interface; other site 574521008571 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 574521008572 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 574521008573 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 574521008574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521008575 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 574521008576 putative L-valine exporter; Provisional; Region: PRK10408 574521008577 transcriptional repressor MprA; Provisional; Region: PRK10870 574521008578 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 574521008579 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 574521008580 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521008581 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521008582 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 574521008583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521008584 putative substrate translocation pore; other site 574521008585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521008586 RNA ligase; Region: RNA_ligase; pfam09414 574521008587 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 574521008588 Zn2+ binding site [ion binding]; other site 574521008589 Mg2+ binding site [ion binding]; other site 574521008590 AAA domain; Region: AAA_33; pfam13671 574521008591 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521008592 Transposase IS200 like; Region: Y1_Tnp; pfam01797 574521008593 S-ribosylhomocysteinase; Provisional; Region: PRK02260 574521008594 glutamate--cysteine ligase; Provisional; Region: PRK02107 574521008595 Predicted membrane protein [Function unknown]; Region: COG1238 574521008596 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 574521008597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521008598 motif II; other site 574521008599 carbon storage regulator; Provisional; Region: PRK01712 574521008600 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 574521008601 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 574521008602 motif 1; other site 574521008603 active site 574521008604 motif 2; other site 574521008605 motif 3; other site 574521008606 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 574521008607 DHHA1 domain; Region: DHHA1; pfam02272 574521008608 recombination regulator RecX; Reviewed; Region: recX; PRK00117 574521008609 recombinase A; Provisional; Region: recA; PRK09354 574521008610 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 574521008611 hexamer interface [polypeptide binding]; other site 574521008612 Walker A motif; other site 574521008613 ATP binding site [chemical binding]; other site 574521008614 Walker B motif; other site 574521008615 hypothetical protein; Validated; Region: PRK03661 574521008616 Transglycosylase SLT domain; Region: SLT_2; pfam13406 574521008617 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 574521008618 N-acetyl-D-glucosamine binding site [chemical binding]; other site 574521008619 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 574521008620 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 574521008621 putative active site [active] 574521008622 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 574521008623 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 574521008624 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 574521008625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521008626 Walker A motif; other site 574521008627 ATP binding site [chemical binding]; other site 574521008628 Walker B motif; other site 574521008629 arginine finger; other site 574521008630 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 574521008631 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 574521008632 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 574521008633 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 574521008634 iron binding site [ion binding]; other site 574521008635 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 574521008636 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 574521008637 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521008638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 574521008639 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521008640 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521008641 pseudogene, N-ter part of transposase Orf2 of ISE1397, disrupted by IS insertion 574521008642 pseudogene, C-ter part of transposase Orf2 of IS3 family IS element, disrupted by ISEc21 574521008643 Transposase; Region: DEDD_Tnp_IS110; pfam01548 574521008644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 574521008645 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 574521008646 pseudogene, transposase Orf2 of IS3 family IS element, disrupted by ISEc21 574521008647 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 574521008648 Transposase; Region: HTH_Tnp_1; cl17663 574521008649 pseudogene, C-ter part of transposase Orf2 of ISE1397, disrupted by IS insertions 574521008650 pseudogene, carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases, truncated by premature stop codon 574521008651 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 574521008652 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 574521008653 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521008654 Transposase IS200 like; Region: Y1_Tnp; pfam01797 574521008655 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521008656 non-specific DNA binding site [nucleotide binding]; other site 574521008657 salt bridge; other site 574521008658 sequence-specific DNA binding site [nucleotide binding]; other site 574521008659 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 574521008660 nickel binding site [ion binding]; other site 574521008661 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 574521008662 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 574521008663 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 574521008664 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 574521008665 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 574521008666 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 574521008667 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 574521008668 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 574521008669 NADH dehydrogenase; Region: NADHdh; cl00469 574521008670 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 574521008671 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 574521008672 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 574521008673 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 574521008674 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 574521008675 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 574521008676 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 574521008677 hydrogenase assembly chaperone; Provisional; Region: PRK10409 574521008678 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 574521008679 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 574521008680 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 574521008681 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 574521008682 dimerization interface [polypeptide binding]; other site 574521008683 ATP binding site [chemical binding]; other site 574521008684 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 574521008685 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 574521008686 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 574521008687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521008688 Walker A motif; other site 574521008689 ATP binding site [chemical binding]; other site 574521008690 Walker B motif; other site 574521008691 arginine finger; other site 574521008692 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 574521008693 molybdenum-pterin binding domain; Region: Mop; TIGR00638 574521008694 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 574521008695 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 574521008696 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 574521008697 MutS domain I; Region: MutS_I; pfam01624 574521008698 MutS domain II; Region: MutS_II; pfam05188 574521008699 MutS domain III; Region: MutS_III; pfam05192 574521008700 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 574521008701 Walker A/P-loop; other site 574521008702 ATP binding site [chemical binding]; other site 574521008703 Q-loop/lid; other site 574521008704 ABC transporter signature motif; other site 574521008705 Walker B; other site 574521008706 D-loop; other site 574521008707 H-loop/switch region; other site 574521008708 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 574521008709 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 574521008710 active site 574521008711 metal binding site [ion binding]; metal-binding site 574521008712 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 574521008713 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 574521008714 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 574521008715 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 574521008716 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 574521008717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 574521008718 putative aldolase; Validated; Region: PRK08130 574521008719 active site 574521008720 intersubunit interface [polypeptide binding]; other site 574521008721 Zn2+ binding site [ion binding]; other site 574521008722 hypothetical protein; Provisional; Region: PRK09989 574521008723 putative transporter; Provisional; Region: PRK09821 574521008724 GntP family permease; Region: GntP_permease; pfam02447 574521008725 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 574521008726 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 574521008727 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 574521008728 Flavoprotein; Region: Flavoprotein; pfam02441 574521008729 MarR family; Region: MarR_2; cl17246 574521008730 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 574521008731 pseudogene, RNA polymerase, sigma S (sigma 38) factor, truncated by frameshift mutation 574521008732 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 574521008733 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 574521008734 Peptidase family M23; Region: Peptidase_M23; pfam01551 574521008735 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 574521008736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521008737 S-adenosylmethionine binding site [chemical binding]; other site 574521008738 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 574521008739 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 574521008740 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 574521008741 Permutation of conserved domain; other site 574521008742 active site 574521008743 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 574521008744 homotrimer interaction site [polypeptide binding]; other site 574521008745 zinc binding site [ion binding]; other site 574521008746 CDP-binding sites; other site 574521008747 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 574521008748 substrate binding site; other site 574521008749 dimer interface; other site 574521008750 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 574521008751 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 574521008752 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 574521008753 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 574521008754 ligand-binding site [chemical binding]; other site 574521008755 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 574521008756 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 574521008757 CysD dimerization site [polypeptide binding]; other site 574521008758 G1 box; other site 574521008759 putative GEF interaction site [polypeptide binding]; other site 574521008760 GTP/Mg2+ binding site [chemical binding]; other site 574521008761 Switch I region; other site 574521008762 G2 box; other site 574521008763 G3 box; other site 574521008764 Switch II region; other site 574521008765 G4 box; other site 574521008766 G5 box; other site 574521008767 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 574521008768 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 574521008769 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 574521008770 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 574521008771 Active Sites [active] 574521008772 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 574521008773 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 574521008774 metal binding site [ion binding]; metal-binding site 574521008775 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521008776 Homeodomain-like domain; Region: HTH_32; pfam13565 574521008777 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 574521008778 Integrase core domain; Region: rve; pfam00665 574521008779 Integrase core domain; Region: rve_3; pfam13683 574521008780 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 574521008781 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 574521008782 Active Sites [active] 574521008783 sulfite reductase subunit beta; Provisional; Region: PRK13504 574521008784 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 574521008785 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 574521008786 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 574521008787 Flavodoxin; Region: Flavodoxin_1; pfam00258 574521008788 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 574521008789 FAD binding pocket [chemical binding]; other site 574521008790 FAD binding motif [chemical binding]; other site 574521008791 catalytic residues [active] 574521008792 NAD binding pocket [chemical binding]; other site 574521008793 phosphate binding motif [ion binding]; other site 574521008794 beta-alpha-beta structure motif; other site 574521008795 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 574521008796 active site 574521008797 FAD dependent oxidoreductase; Region: DAO; pfam01266 574521008798 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 574521008799 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 574521008800 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 574521008801 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 574521008802 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 574521008803 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 574521008804 Ligand binding site [chemical binding]; other site 574521008805 Electron transfer flavoprotein domain; Region: ETF; pfam01012 574521008806 benzoate transport; Region: 2A0115; TIGR00895 574521008807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521008808 putative substrate translocation pore; other site 574521008809 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 574521008810 FAD binding domain; Region: FAD_binding_4; pfam01565 574521008811 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 574521008812 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 574521008813 NADP binding site [chemical binding]; other site 574521008814 homodimer interface [polypeptide binding]; other site 574521008815 active site 574521008816 Major Facilitator Superfamily; Region: MFS_1; pfam07690 574521008817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521008818 putative substrate translocation pore; other site 574521008819 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 574521008820 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 574521008821 nucleotide binding site [chemical binding]; other site 574521008822 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 574521008823 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 574521008824 putative substrate binding site [chemical binding]; other site 574521008825 putative ATP binding site [chemical binding]; other site 574521008826 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 574521008827 trimer interface; other site 574521008828 sugar binding site [chemical binding]; other site 574521008829 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 574521008830 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 574521008831 active site turn [active] 574521008832 phosphorylation site [posttranslational modification] 574521008833 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 574521008834 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 574521008835 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 574521008836 substrate binding [chemical binding]; other site 574521008837 active site 574521008838 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 574521008839 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 574521008840 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521008841 DNA binding site [nucleotide binding] 574521008842 domain linker motif; other site 574521008843 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 574521008844 dimerization interface [polypeptide binding]; other site 574521008845 ligand binding site [chemical binding]; other site 574521008846 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 574521008847 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 574521008848 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 574521008849 Repair protein; Region: Repair_PSII; pfam04536 574521008850 enolase; Provisional; Region: eno; PRK00077 574521008851 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 574521008852 dimer interface [polypeptide binding]; other site 574521008853 metal binding site [ion binding]; metal-binding site 574521008854 substrate binding pocket [chemical binding]; other site 574521008855 CTP synthetase; Validated; Region: pyrG; PRK05380 574521008856 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 574521008857 Catalytic site [active] 574521008858 active site 574521008859 UTP binding site [chemical binding]; other site 574521008860 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 574521008861 active site 574521008862 putative oxyanion hole; other site 574521008863 catalytic triad [active] 574521008864 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 574521008865 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 574521008866 homodimer interface [polypeptide binding]; other site 574521008867 metal binding site [ion binding]; metal-binding site 574521008868 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 574521008869 homodimer interface [polypeptide binding]; other site 574521008870 active site 574521008871 putative chemical substrate binding site [chemical binding]; other site 574521008872 metal binding site [ion binding]; metal-binding site 574521008873 toxin MazF; Provisional; Region: PRK09907 574521008874 antitoxin MazE; Provisional; Region: PRK09798 574521008875 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 574521008876 HD domain; Region: HD_4; pfam13328 574521008877 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 574521008878 synthetase active site [active] 574521008879 NTP binding site [chemical binding]; other site 574521008880 metal binding site [ion binding]; metal-binding site 574521008881 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 574521008882 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 574521008883 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 574521008884 TRAM domain; Region: TRAM; pfam01938 574521008885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521008886 S-adenosylmethionine binding site [chemical binding]; other site 574521008887 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 574521008888 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 574521008889 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 574521008890 dimerization interface [polypeptide binding]; other site 574521008891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521008892 dimer interface [polypeptide binding]; other site 574521008893 phosphorylation site [posttranslational modification] 574521008894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521008895 ATP binding site [chemical binding]; other site 574521008896 Mg2+ binding site [ion binding]; other site 574521008897 G-X-G motif; other site 574521008898 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 574521008899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521008900 active site 574521008901 phosphorylation site [posttranslational modification] 574521008902 intermolecular recognition site; other site 574521008903 dimerization interface [polypeptide binding]; other site 574521008904 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 574521008905 putative binding surface; other site 574521008906 active site 574521008907 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 574521008908 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 574521008909 active site 574521008910 tetramer interface [polypeptide binding]; other site 574521008911 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 574521008912 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 574521008913 active site 574521008914 tetramer interface [polypeptide binding]; other site 574521008915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521008916 D-galactonate transporter; Region: 2A0114; TIGR00893 574521008917 putative substrate translocation pore; other site 574521008918 flavodoxin; Provisional; Region: PRK08105 574521008919 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 574521008920 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 574521008921 probable active site [active] 574521008922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 574521008923 SecY interacting protein Syd; Provisional; Region: PRK04968 574521008924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 574521008925 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 574521008926 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 574521008927 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 574521008928 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 574521008929 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 574521008930 serine transporter; Region: stp; TIGR00814 574521008931 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 574521008932 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 574521008933 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 574521008934 flap endonuclease-like protein; Provisional; Region: PRK09482 574521008935 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 574521008936 active site 574521008937 metal binding site 1 [ion binding]; metal-binding site 574521008938 putative 5' ssDNA interaction site; other site 574521008939 metal binding site 3; metal-binding site 574521008940 metal binding site 2 [ion binding]; metal-binding site 574521008941 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 574521008942 putative DNA binding site [nucleotide binding]; other site 574521008943 putative metal binding site [ion binding]; other site 574521008944 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 574521008945 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 574521008946 dimer interface [polypeptide binding]; other site 574521008947 active site 574521008948 metal binding site [ion binding]; metal-binding site 574521008949 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 574521008950 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 574521008951 intersubunit interface [polypeptide binding]; other site 574521008952 active site 574521008953 Zn2+ binding site [ion binding]; other site 574521008954 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 574521008955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521008956 putative substrate translocation pore; other site 574521008957 L-fucose isomerase; Provisional; Region: fucI; PRK10991 574521008958 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 574521008959 hexamer (dimer of trimers) interface [polypeptide binding]; other site 574521008960 trimer interface [polypeptide binding]; other site 574521008961 substrate binding site [chemical binding]; other site 574521008962 Mn binding site [ion binding]; other site 574521008963 L-fuculokinase; Provisional; Region: PRK10331 574521008964 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 574521008965 nucleotide binding site [chemical binding]; other site 574521008966 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 574521008967 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 574521008968 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 574521008969 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 574521008970 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 574521008971 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 574521008972 hypothetical protein; Provisional; Region: PRK10873 574521008973 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 574521008974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521008975 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 574521008976 dimerization interface [polypeptide binding]; other site 574521008977 substrate binding pocket [chemical binding]; other site 574521008978 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 574521008979 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 574521008980 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 574521008981 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 574521008982 catalytic residue [active] 574521008983 CsdA-binding activator; Provisional; Region: PRK15019 574521008984 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 574521008985 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 574521008986 putative ATP binding site [chemical binding]; other site 574521008987 putative substrate interface [chemical binding]; other site 574521008988 murein transglycosylase A; Provisional; Region: mltA; PRK11162 574521008989 MltA specific insert domain; Region: MltA; pfam03562 574521008990 3D domain; Region: 3D; pfam06725 574521008991 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 574521008992 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 574521008993 putative ligand binding site [chemical binding]; other site 574521008994 putative NAD binding site [chemical binding]; other site 574521008995 catalytic site [active] 574521008996 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 574521008997 putative active site [active] 574521008998 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 574521008999 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 574521009000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521009001 homodimer interface [polypeptide binding]; other site 574521009002 catalytic residue [active] 574521009003 pseudogene, PTS system, maltose and glucose-specific IIABC component, truncated by premature stop codon 574521009004 CAT RNA binding domain; Region: CAT_RBD; pfam03123 574521009005 PRD domain; Region: PRD; pfam00874 574521009006 PRD domain; Region: PRD; pfam00874 574521009007 AMIN domain; Region: AMIN; pfam11741 574521009008 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 574521009009 active site 574521009010 metal binding site [ion binding]; metal-binding site 574521009011 N-acetylglutamate synthase; Validated; Region: PRK05279 574521009012 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 574521009013 putative feedback inhibition sensing region; other site 574521009014 putative nucleotide binding site [chemical binding]; other site 574521009015 putative substrate binding site [chemical binding]; other site 574521009016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521009017 Coenzyme A binding pocket [chemical binding]; other site 574521009018 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 574521009019 AAA domain; Region: AAA_30; pfam13604 574521009020 Family description; Region: UvrD_C_2; pfam13538 574521009021 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 574521009022 protease3; Provisional; Region: PRK15101 574521009023 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 574521009024 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 574521009025 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 574521009026 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 574521009027 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 574521009028 hypothetical protein; Provisional; Region: PRK10332 574521009029 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 574521009030 hypothetical protein; Provisional; Region: PRK11521 574521009031 hypothetical protein; Provisional; Region: PRK10557 574521009032 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 574521009033 hypothetical protein; Provisional; Region: PRK10506 574521009034 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 574521009035 thymidylate synthase; Reviewed; Region: thyA; PRK01827 574521009036 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 574521009037 dimerization interface [polypeptide binding]; other site 574521009038 active site 574521009039 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 574521009040 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 574521009041 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 574521009042 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 574521009043 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 574521009044 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 574521009045 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 574521009046 putative active site [active] 574521009047 Ap4A binding site [chemical binding]; other site 574521009048 nudix motif; other site 574521009049 putative metal binding site [ion binding]; other site 574521009050 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 574521009051 putative DNA-binding cleft [nucleotide binding]; other site 574521009052 putative DNA clevage site; other site 574521009053 molecular lever; other site 574521009054 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 574521009055 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 574521009056 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 574521009057 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 574521009058 active site 574521009059 catalytic tetrad [active] 574521009060 lysophospholipid transporter LplT; Provisional; Region: PRK11195 574521009061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521009062 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 574521009063 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 574521009064 putative acyl-acceptor binding pocket; other site 574521009065 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 574521009066 acyl-activating enzyme (AAE) consensus motif; other site 574521009067 putative AMP binding site [chemical binding]; other site 574521009068 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 574521009069 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521009070 DNA binding site [nucleotide binding] 574521009071 domain linker motif; other site 574521009072 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 574521009073 dimerization interface (closed form) [polypeptide binding]; other site 574521009074 ligand binding site [chemical binding]; other site 574521009075 diaminopimelate decarboxylase; Provisional; Region: PRK11165 574521009076 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 574521009077 active site 574521009078 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 574521009079 substrate binding site [chemical binding]; other site 574521009080 catalytic residues [active] 574521009081 dimer interface [polypeptide binding]; other site 574521009082 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 574521009083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521009084 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 574521009085 putative dimerization interface [polypeptide binding]; other site 574521009086 putative racemase; Provisional; Region: PRK10200 574521009087 aspartate racemase; Region: asp_race; TIGR00035 574521009088 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 574521009089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521009090 putative substrate translocation pore; other site 574521009091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521009092 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521009093 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 574521009094 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 574521009095 NADP binding site [chemical binding]; other site 574521009096 homodimer interface [polypeptide binding]; other site 574521009097 active site 574521009098 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 574521009099 putative acyltransferase; Provisional; Region: PRK05790 574521009100 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 574521009101 dimer interface [polypeptide binding]; other site 574521009102 active site 574521009103 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 574521009104 serine transporter; Region: stp; TIGR00814 574521009105 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 574521009106 Peptidase family M23; Region: Peptidase_M23; pfam01551 574521009107 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 574521009108 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 574521009109 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 574521009110 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 574521009111 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 574521009112 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 574521009113 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 574521009114 catalytic loop [active] 574521009115 iron binding site [ion binding]; other site 574521009116 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 574521009117 GAF domain; Region: GAF; cl17456 574521009118 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 574521009119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 574521009120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521009121 Walker A motif; other site 574521009122 ATP binding site [chemical binding]; other site 574521009123 Walker B motif; other site 574521009124 arginine finger; other site 574521009125 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 574521009126 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 574521009127 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 574521009128 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 574521009129 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 574521009130 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 574521009131 catalytic residue [active] 574521009132 peptidase; Reviewed; Region: PRK13004 574521009133 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 574521009134 putative metal binding site [ion binding]; other site 574521009135 putative dimer interface [polypeptide binding]; other site 574521009136 D-hydantoinase; Region: D-hydantoinase; TIGR02033 574521009137 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 574521009138 tetramer interface [polypeptide binding]; other site 574521009139 active site 574521009140 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 574521009141 carbamate kinase; Reviewed; Region: PRK12686 574521009142 putative substrate binding site [chemical binding]; other site 574521009143 homodimer interface [polypeptide binding]; other site 574521009144 nucleotide binding site [chemical binding]; other site 574521009145 nucleotide binding site [chemical binding]; other site 574521009146 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 574521009147 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 574521009148 XdhC Rossmann domain; Region: XdhC_C; pfam13478 574521009149 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 574521009150 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 574521009151 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 574521009152 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 574521009153 Ligand binding site; other site 574521009154 metal-binding site 574521009155 pseudogene, oxidoreductase, Fe-S subunit, disrupted by ISEc13 574521009156 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521009157 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 574521009158 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 574521009159 active site 574521009160 putative substrate binding pocket [chemical binding]; other site 574521009161 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 574521009162 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 574521009163 pseudogene, fused xanthine/hypoxanthine oxidase: molybdopterin-binding subunit/Fe-S binding subunit, truncated by premature stop codon 574521009164 uracil-xanthine permease; Region: ncs2; TIGR00801 574521009165 guanine deaminase; Provisional; Region: PRK09228 574521009166 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 574521009167 active site 574521009168 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 574521009169 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 574521009170 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 574521009171 4Fe-4S binding domain; Region: Fer4; pfam00037 574521009172 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 574521009173 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521009174 xanthine permease; Region: pbuX; TIGR03173 574521009175 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 574521009176 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 574521009177 active site 574521009178 metal binding site [ion binding]; metal-binding site 574521009179 nudix motif; other site 574521009180 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 574521009181 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 574521009182 dimer interface [polypeptide binding]; other site 574521009183 putative anticodon binding site; other site 574521009184 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 574521009185 motif 1; other site 574521009186 active site 574521009187 motif 2; other site 574521009188 motif 3; other site 574521009189 peptide chain release factor 2; Validated; Region: prfB; PRK00578 574521009190 This domain is found in peptide chain release factors; Region: PCRF; smart00937 574521009191 RF-1 domain; Region: RF-1; pfam00472 574521009192 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 574521009193 DHH family; Region: DHH; pfam01368 574521009194 DHHA1 domain; Region: DHHA1; pfam02272 574521009195 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 574521009196 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 574521009197 dimerization domain [polypeptide binding]; other site 574521009198 dimer interface [polypeptide binding]; other site 574521009199 catalytic residues [active] 574521009200 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 574521009201 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 574521009202 active site 574521009203 Int/Topo IB signature motif; other site 574521009204 flavodoxin FldB; Provisional; Region: PRK12359 574521009205 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 574521009206 hypothetical protein; Provisional; Region: PRK10878 574521009207 putative global regulator; Reviewed; Region: PRK09559 574521009208 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 574521009209 hemolysin; Provisional; Region: PRK15087 574521009210 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 574521009211 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 574521009212 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 574521009213 beta-galactosidase; Region: BGL; TIGR03356 574521009214 glycine dehydrogenase; Provisional; Region: PRK05367 574521009215 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 574521009216 tetramer interface [polypeptide binding]; other site 574521009217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521009218 catalytic residue [active] 574521009219 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 574521009220 tetramer interface [polypeptide binding]; other site 574521009221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521009222 catalytic residue [active] 574521009223 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 574521009224 lipoyl attachment site [posttranslational modification]; other site 574521009225 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 574521009226 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 574521009227 oxidoreductase; Provisional; Region: PRK08013 574521009228 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 574521009229 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 574521009230 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 574521009231 proline aminopeptidase P II; Provisional; Region: PRK10879 574521009232 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 574521009233 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 574521009234 active site 574521009235 hypothetical protein; Reviewed; Region: PRK01736 574521009236 Z-ring-associated protein; Provisional; Region: PRK10972 574521009237 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 574521009238 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 574521009239 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 574521009240 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 574521009241 ligand binding site [chemical binding]; other site 574521009242 NAD binding site [chemical binding]; other site 574521009243 tetramer interface [polypeptide binding]; other site 574521009244 catalytic site [active] 574521009245 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 574521009246 L-serine binding site [chemical binding]; other site 574521009247 ACT domain interface; other site 574521009248 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 574521009249 tetramer (dimer of dimers) interface [polypeptide binding]; other site 574521009250 active site 574521009251 dimer interface [polypeptide binding]; other site 574521009252 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 574521009253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521009254 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 574521009255 putative dimerization interface [polypeptide binding]; other site 574521009256 pseudogene, N-ter part of methylmalonyl-CoA mutase 574521009257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521009258 Transcriptional regulator [Transcription]; Region: LysR; COG0583 574521009259 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 574521009260 dimerization interface [polypeptide binding]; other site 574521009261 Uncharacterized conserved protein [Function unknown]; Region: COG2968 574521009262 oxidative stress defense protein; Provisional; Region: PRK11087 574521009263 arginine exporter protein; Provisional; Region: PRK09304 574521009264 mechanosensitive channel MscS; Provisional; Region: PRK10334 574521009265 Mechanosensitive ion channel; Region: MS_channel; pfam00924 574521009266 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 574521009267 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 574521009268 active site 574521009269 intersubunit interface [polypeptide binding]; other site 574521009270 zinc binding site [ion binding]; other site 574521009271 Na+ binding site [ion binding]; other site 574521009272 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 574521009273 Phosphoglycerate kinase; Region: PGK; pfam00162 574521009274 substrate binding site [chemical binding]; other site 574521009275 hinge regions; other site 574521009276 ADP binding site [chemical binding]; other site 574521009277 catalytic site [active] 574521009278 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 574521009279 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 574521009280 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 574521009281 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 574521009282 trimer interface [polypeptide binding]; other site 574521009283 putative Zn binding site [ion binding]; other site 574521009284 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 574521009285 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 574521009286 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 574521009287 Walker A/P-loop; other site 574521009288 ATP binding site [chemical binding]; other site 574521009289 Q-loop/lid; other site 574521009290 ABC transporter signature motif; other site 574521009291 Walker B; other site 574521009292 D-loop; other site 574521009293 H-loop/switch region; other site 574521009294 pseudogene, ABC transporter ATP-binding subunit, truncated by premature stop codon 574521009295 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 574521009296 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 574521009297 active site 574521009298 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 574521009299 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 574521009300 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 574521009301 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 574521009302 putative active site [active] 574521009303 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 574521009304 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 574521009305 putative NAD(P) binding site [chemical binding]; other site 574521009306 catalytic Zn binding site [ion binding]; other site 574521009307 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 574521009308 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 574521009309 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 574521009310 active site 574521009311 P-loop; other site 574521009312 phosphorylation site [posttranslational modification] 574521009313 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 574521009314 active site 574521009315 phosphorylation site [posttranslational modification] 574521009316 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 574521009317 SPFH domain / Band 7 family; Region: Band_7; pfam01145 574521009318 transketolase; Reviewed; Region: PRK12753 574521009319 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 574521009320 TPP-binding site [chemical binding]; other site 574521009321 dimer interface [polypeptide binding]; other site 574521009322 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 574521009323 PYR/PP interface [polypeptide binding]; other site 574521009324 dimer interface [polypeptide binding]; other site 574521009325 TPP binding site [chemical binding]; other site 574521009326 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 574521009327 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 574521009328 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 574521009329 agmatinase; Region: agmatinase; TIGR01230 574521009330 oligomer interface [polypeptide binding]; other site 574521009331 putative active site [active] 574521009332 Mn binding site [ion binding]; other site 574521009333 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 574521009334 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 574521009335 dimer interface [polypeptide binding]; other site 574521009336 active site 574521009337 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 574521009338 catalytic residues [active] 574521009339 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 574521009340 Virulence promoting factor; Region: YqgB; pfam11036 574521009341 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 574521009342 S-adenosylmethionine synthetase; Validated; Region: PRK05250 574521009343 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 574521009344 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 574521009345 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 574521009346 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 574521009347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521009348 putative substrate translocation pore; other site 574521009349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521009350 hypothetical protein; Provisional; Region: PRK04860 574521009351 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 574521009352 DNA-specific endonuclease I; Provisional; Region: PRK15137 574521009353 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 574521009354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 574521009355 RNA methyltransferase, RsmE family; Region: TIGR00046 574521009356 glutathione synthetase; Provisional; Region: PRK05246 574521009357 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 574521009358 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 574521009359 hypothetical protein; Validated; Region: PRK00228 574521009360 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 574521009361 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 574521009362 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 574521009363 Walker A motif; other site 574521009364 ATP binding site [chemical binding]; other site 574521009365 Walker B motif; other site 574521009366 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 574521009367 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 574521009368 catalytic residue [active] 574521009369 YGGT family; Region: YGGT; pfam02325 574521009370 YGGT family; Region: YGGT; pfam02325 574521009371 hypothetical protein; Validated; Region: PRK05090 574521009372 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 574521009373 active site 574521009374 dimerization interface [polypeptide binding]; other site 574521009375 HemN family oxidoreductase; Provisional; Region: PRK05660 574521009376 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521009377 FeS/SAM binding site; other site 574521009378 HemN C-terminal domain; Region: HemN_C; pfam06969 574521009379 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 574521009380 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 574521009381 homodimer interface [polypeptide binding]; other site 574521009382 active site 574521009383 hypothetical protein; Provisional; Region: PRK10626 574521009384 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 574521009385 hypothetical protein; Provisional; Region: PRK11702 574521009386 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 574521009387 adenine DNA glycosylase; Provisional; Region: PRK10880 574521009388 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 574521009389 minor groove reading motif; other site 574521009390 helix-hairpin-helix signature motif; other site 574521009391 substrate binding pocket [chemical binding]; other site 574521009392 active site 574521009393 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 574521009394 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 574521009395 DNA binding and oxoG recognition site [nucleotide binding] 574521009396 oxidative damage protection protein; Provisional; Region: PRK05408 574521009397 murein transglycosylase C; Provisional; Region: mltC; PRK11671 574521009398 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 574521009399 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 574521009400 N-acetyl-D-glucosamine binding site [chemical binding]; other site 574521009401 catalytic residue [active] 574521009402 nucleoside transporter; Region: 2A0110; TIGR00889 574521009403 ornithine decarboxylase; Provisional; Region: PRK13578 574521009404 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 574521009405 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 574521009406 homodimer interface [polypeptide binding]; other site 574521009407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521009408 catalytic residue [active] 574521009409 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 574521009410 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 574521009411 integrative element E2348_IE6 574521009412 integrase; Provisional; Region: PRK09692 574521009413 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 574521009414 active site 574521009415 Int/Topo IB signature motif; other site 574521009416 E2348_IE6; pseudogene, C-ter part of transposase of ISEc8 574521009417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 574521009418 Homeodomain-like domain; Region: HTH_23; pfam13384 574521009419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 574521009420 Transposase; Region: HTH_Tnp_1; pfam01527 574521009421 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 574521009422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 574521009423 E2348_IE6; pseudogene, transposase Orf3 of IS683, C-ter part missing 574521009424 E2348_IE6; pseudogene, helicase, truncated at C-ter by IS683 insertion 574521009425 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 574521009426 E2348_IE6; pseudogene, transposase of IS608, disrupted by multiple mutations 574521009427 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 574521009428 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 574521009429 type III secretion system protein; Provisional; Region: PRK15384; cl14665 574521009430 E2348_IE6; pseudogene, transpsase of IS630 family IS element, truncated by premature stop codon 574521009431 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 574521009432 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 574521009433 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 574521009434 cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586 574521009435 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 574521009436 E2348_IE6; pseudogene, N-ter part of transposase of IS604 574521009437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 574521009438 Transposase; Region: HTH_Tnp_1; pfam01527 574521009439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 574521009440 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 574521009441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 574521009442 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 574521009443 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 574521009444 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 574521009445 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521009446 Homeodomain-like domain; Region: HTH_32; pfam13565 574521009447 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 574521009448 Integrase core domain; Region: rve; pfam00665 574521009449 Integrase core domain; Region: rve_3; pfam13683 574521009450 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 574521009451 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 574521009452 GspL-like protein; Provisional; Region: PRK09662 574521009453 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 574521009454 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 574521009455 type II secretion system protein J; Region: gspJ; TIGR01711 574521009456 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 574521009457 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 574521009458 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 574521009459 Type II transport protein GspH; Region: GspH; pfam12019 574521009460 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 574521009461 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 574521009462 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 574521009463 type II secretion system protein F; Region: GspF; TIGR02120 574521009464 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 574521009465 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 574521009466 type II secretion system protein E; Region: type_II_gspE; TIGR02533 574521009467 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 574521009468 Walker A motif; other site 574521009469 ATP binding site [chemical binding]; other site 574521009470 Walker B motif; other site 574521009471 type II secretion system protein D; Region: type_II_gspD; TIGR02517 574521009472 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 574521009473 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 574521009474 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 574521009475 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 574521009476 putative type II secretion protein GspC; Provisional; Region: PRK09681 574521009477 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 574521009478 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 574521009479 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 574521009480 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 574521009481 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 574521009482 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 574521009483 Peptidase M60-like family; Region: M60-like; pfam13402 574521009484 glycolate transporter; Provisional; Region: PRK09695 574521009485 L-lactate permease; Region: Lactate_perm; cl00701 574521009486 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 574521009487 active site 574521009488 hypothetical protein; Provisional; Region: PRK09732 574521009489 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 574521009490 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 574521009491 Cysteine-rich domain; Region: CCG; pfam02754 574521009492 Cysteine-rich domain; Region: CCG; pfam02754 574521009493 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 574521009494 FAD binding domain; Region: FAD_binding_4; pfam01565 574521009495 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 574521009496 FAD binding domain; Region: FAD_binding_4; pfam01565 574521009497 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 574521009498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521009499 DNA-binding site [nucleotide binding]; DNA binding site 574521009500 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 574521009501 acyl-CoA synthetase; Validated; Region: PRK09192 574521009502 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 574521009503 acyl-activating enzyme (AAE) consensus motif; other site 574521009504 active site 574521009505 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 574521009506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 574521009507 NAD(P) binding site [chemical binding]; other site 574521009508 active site 574521009509 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 574521009510 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 574521009511 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 574521009512 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 574521009513 catalytic residue [active] 574521009514 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 574521009515 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 574521009516 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 574521009517 Predicted permeases [General function prediction only]; Region: COG0795 574521009518 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 574521009519 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 574521009520 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 574521009521 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 574521009522 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 574521009523 active site 574521009524 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 574521009525 TMP-binding site; other site 574521009526 ATP-binding site [chemical binding]; other site 574521009527 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 574521009528 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 574521009529 TMP-binding site; other site 574521009530 ATP-binding site [chemical binding]; other site 574521009531 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 574521009532 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 574521009533 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 574521009534 CHAP domain; Region: CHAP; pfam05257 574521009535 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 574521009536 putative S-transferase; Provisional; Region: PRK11752 574521009537 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 574521009538 C-terminal domain interface [polypeptide binding]; other site 574521009539 GSH binding site (G-site) [chemical binding]; other site 574521009540 dimer interface [polypeptide binding]; other site 574521009541 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 574521009542 dimer interface [polypeptide binding]; other site 574521009543 N-terminal domain interface [polypeptide binding]; other site 574521009544 active site 574521009545 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 574521009546 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 574521009547 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 574521009548 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 574521009549 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 574521009550 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 574521009551 putative substrate-binding site; other site 574521009552 nickel binding site [ion binding]; other site 574521009553 hydrogenase 2 large subunit; Provisional; Region: PRK10467 574521009554 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 574521009555 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 574521009556 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 574521009557 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 574521009558 4Fe-4S binding domain; Region: Fer4_6; pfam12837 574521009559 hydrogenase 2 small subunit; Provisional; Region: PRK10468 574521009560 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 574521009561 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 574521009562 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 574521009563 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 574521009564 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 574521009565 pseudogene, aldo-keto reductase, disrupted by IS1397 574521009566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 574521009567 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521009568 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521009569 HTH-like domain; Region: HTH_21; pfam13276 574521009570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 574521009571 Integrase core domain; Region: rve; pfam00665 574521009572 Integrase core domain; Region: rve_2; pfam13333 574521009573 hypothetical protein; Provisional; Region: PRK05208 574521009574 oxidoreductase; Provisional; Region: PRK07985 574521009575 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 574521009576 NAD binding site [chemical binding]; other site 574521009577 metal binding site [ion binding]; metal-binding site 574521009578 active site 574521009579 biopolymer transport protein ExbD; Provisional; Region: PRK11267 574521009580 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 574521009581 biopolymer transport protein ExbB; Provisional; Region: PRK10414 574521009582 cystathionine beta-lyase; Provisional; Region: PRK08114 574521009583 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 574521009584 homodimer interface [polypeptide binding]; other site 574521009585 substrate-cofactor binding pocket; other site 574521009586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521009587 catalytic residue [active] 574521009588 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 574521009589 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 574521009590 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 574521009591 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 574521009592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521009593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521009594 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 574521009595 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 574521009596 dimer interface [polypeptide binding]; other site 574521009597 active site 574521009598 metal binding site [ion binding]; metal-binding site 574521009599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 574521009600 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 574521009601 active site 574521009602 catalytic tetrad [active] 574521009603 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 574521009604 putative outer membrane lipoprotein; Provisional; Region: PRK09973 574521009605 hypothetical protein; Provisional; Region: PRK01254 574521009606 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 574521009607 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 574521009608 Transcriptional regulators [Transcription]; Region: FadR; COG2186 574521009609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521009610 DNA-binding site [nucleotide binding]; DNA binding site 574521009611 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 574521009612 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 574521009613 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 574521009614 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 574521009615 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 574521009616 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 574521009617 putative NAD(P) binding site [chemical binding]; other site 574521009618 catalytic Zn binding site [ion binding]; other site 574521009619 structural Zn binding site [ion binding]; other site 574521009620 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 574521009621 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 574521009622 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 574521009623 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 574521009624 DctM-like transporters; Region: DctM; pfam06808 574521009625 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 574521009626 FtsI repressor; Provisional; Region: PRK10883 574521009627 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 574521009628 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 574521009629 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 574521009630 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 574521009631 putative acyl-acceptor binding pocket; other site 574521009632 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 574521009633 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 574521009634 CAP-like domain; other site 574521009635 active site 574521009636 primary dimer interface [polypeptide binding]; other site 574521009637 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 574521009638 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 574521009639 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 574521009640 peptide binding site [polypeptide binding]; other site 574521009641 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 574521009642 TIGR00156 family protein; Region: TIGR00156 574521009643 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 574521009644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521009645 active site 574521009646 phosphorylation site [posttranslational modification] 574521009647 intermolecular recognition site; other site 574521009648 dimerization interface [polypeptide binding]; other site 574521009649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521009650 DNA binding site [nucleotide binding] 574521009651 sensor protein QseC; Provisional; Region: PRK10337 574521009652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521009653 dimer interface [polypeptide binding]; other site 574521009654 phosphorylation site [posttranslational modification] 574521009655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521009656 ATP binding site [chemical binding]; other site 574521009657 Mg2+ binding site [ion binding]; other site 574521009658 G-X-G motif; other site 574521009659 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 574521009660 Uncharacterized conserved protein [Function unknown]; Region: COG1359 574521009661 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 574521009662 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 574521009663 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 574521009664 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 574521009665 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 574521009666 siderophore binding site; other site 574521009667 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 574521009668 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 574521009669 ABC-ATPase subunit interface; other site 574521009670 dimer interface [polypeptide binding]; other site 574521009671 putative PBP binding regions; other site 574521009672 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 574521009673 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 574521009674 dimer interface [polypeptide binding]; other site 574521009675 putative PBP binding regions; other site 574521009676 ABC-ATPase subunit interface; other site 574521009677 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 574521009678 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 574521009679 Walker A/P-loop; other site 574521009680 ATP binding site [chemical binding]; other site 574521009681 Q-loop/lid; other site 574521009682 ABC transporter signature motif; other site 574521009683 Walker B; other site 574521009684 D-loop; other site 574521009685 H-loop/switch region; other site 574521009686 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 574521009687 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 574521009688 N-terminal plug; other site 574521009689 ligand-binding site [chemical binding]; other site 574521009690 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 574521009691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521009692 ATP binding site [chemical binding]; other site 574521009693 Mg2+ binding site [ion binding]; other site 574521009694 G-X-G motif; other site 574521009695 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 574521009696 anchoring element; other site 574521009697 dimer interface [polypeptide binding]; other site 574521009698 ATP binding site [chemical binding]; other site 574521009699 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 574521009700 active site 574521009701 metal binding site [ion binding]; metal-binding site 574521009702 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 574521009703 esterase YqiA; Provisional; Region: PRK11071 574521009704 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 574521009705 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 574521009706 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 574521009707 active site 574521009708 metal binding site [ion binding]; metal-binding site 574521009709 hexamer interface [polypeptide binding]; other site 574521009710 putative dehydrogenase; Provisional; Region: PRK11039 574521009711 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 574521009712 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 574521009713 dimer interface [polypeptide binding]; other site 574521009714 ADP-ribose binding site [chemical binding]; other site 574521009715 active site 574521009716 nudix motif; other site 574521009717 metal binding site [ion binding]; metal-binding site 574521009718 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 574521009719 hypothetical protein; Provisional; Region: PRK11653 574521009720 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 574521009721 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 574521009722 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 574521009723 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 574521009724 catalytic residues [active] 574521009725 hinge region; other site 574521009726 alpha helical domain; other site 574521009727 putative disulfide oxidoreductase; Provisional; Region: PRK04307 574521009728 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 574521009729 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 574521009730 putative active site [active] 574521009731 metal binding site [ion binding]; metal-binding site 574521009732 zinc transporter ZupT; Provisional; Region: PRK04201 574521009733 ZIP Zinc transporter; Region: Zip; pfam02535 574521009734 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 574521009735 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 574521009736 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 574521009737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 574521009738 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 574521009739 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 574521009740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 574521009741 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 574521009742 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 574521009743 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 574521009744 putative ribose interaction site [chemical binding]; other site 574521009745 putative ADP binding site [chemical binding]; other site 574521009746 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 574521009747 active site 574521009748 nucleotide binding site [chemical binding]; other site 574521009749 HIGH motif; other site 574521009750 KMSKS motif; other site 574521009751 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 574521009752 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 574521009753 metal binding triad; other site 574521009754 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 574521009755 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 574521009756 metal binding triad; other site 574521009757 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 574521009758 Uncharacterized conserved protein [Function unknown]; Region: COG3025 574521009759 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 574521009760 putative active site [active] 574521009761 putative metal binding residues [ion binding]; other site 574521009762 signature motif; other site 574521009763 putative triphosphate binding site [ion binding]; other site 574521009764 CHAD domain; Region: CHAD; pfam05235 574521009765 SH3 domain-containing protein; Provisional; Region: PRK10884 574521009766 Bacterial SH3 domain homologues; Region: SH3b; smart00287 574521009767 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 574521009768 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 574521009769 active site 574521009770 NTP binding site [chemical binding]; other site 574521009771 metal binding triad [ion binding]; metal-binding site 574521009772 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 574521009773 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 574521009774 Zn2+ binding site [ion binding]; other site 574521009775 Mg2+ binding site [ion binding]; other site 574521009776 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 574521009777 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 574521009778 homooctamer interface [polypeptide binding]; other site 574521009779 active site 574521009780 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 574521009781 transcriptional activator TtdR; Provisional; Region: PRK09801 574521009782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521009783 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 574521009784 putative effector binding pocket; other site 574521009785 putative dimerization interface [polypeptide binding]; other site 574521009786 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 574521009787 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 574521009788 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 574521009789 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 574521009790 transmembrane helices; other site 574521009791 UGMP family protein; Validated; Region: PRK09604 574521009792 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 574521009793 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 574521009794 DNA primase; Validated; Region: dnaG; PRK05667 574521009795 CHC2 zinc finger; Region: zf-CHC2; pfam01807 574521009796 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 574521009797 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 574521009798 active site 574521009799 metal binding site [ion binding]; metal-binding site 574521009800 interdomain interaction site; other site 574521009801 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 574521009802 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 574521009803 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 574521009804 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 574521009805 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 574521009806 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 574521009807 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 574521009808 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 574521009809 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 574521009810 DNA binding residues [nucleotide binding] 574521009811 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 574521009812 pseudogene, G/U mismatch-specific DNA glycosylase, truncated by premature stop codon 574521009813 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 574521009814 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 574521009815 FAD binding pocket [chemical binding]; other site 574521009816 FAD binding motif [chemical binding]; other site 574521009817 phosphate binding motif [ion binding]; other site 574521009818 NAD binding pocket [chemical binding]; other site 574521009819 Predicted transcriptional regulators [Transcription]; Region: COG1695 574521009820 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 574521009821 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 574521009822 PAS fold; Region: PAS_3; pfam08447 574521009823 putative active site [active] 574521009824 heme pocket [chemical binding]; other site 574521009825 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 574521009826 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 574521009827 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 574521009828 dimer interface [polypeptide binding]; other site 574521009829 putative CheW interface [polypeptide binding]; other site 574521009830 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 574521009831 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 574521009832 inhibitor-cofactor binding pocket; inhibition site 574521009833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521009834 catalytic residue [active] 574521009835 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 574521009836 dimer interface [polypeptide binding]; other site 574521009837 putative tRNA-binding site [nucleotide binding]; other site 574521009838 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 574521009839 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521009840 DNA binding site [nucleotide binding] 574521009841 domain linker motif; other site 574521009842 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 574521009843 putative dimerization interface [polypeptide binding]; other site 574521009844 putative ligand binding site [chemical binding]; other site 574521009845 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 574521009846 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 574521009847 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 574521009848 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 574521009849 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 574521009850 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 574521009851 inner membrane transporter YjeM; Provisional; Region: PRK15238 574521009852 alpha-glucosidase; Provisional; Region: PRK10137 574521009853 Protein of unknown function, DUF608; Region: DUF608; pfam04685 574521009854 Trehalase; Region: Trehalase; cl17346 574521009855 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 574521009856 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 574521009857 active site 574521009858 FMN binding site [chemical binding]; other site 574521009859 2,4-decadienoyl-CoA binding site; other site 574521009860 catalytic residue [active] 574521009861 4Fe-4S cluster binding site [ion binding]; other site 574521009862 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 574521009863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521009864 non-specific DNA binding site [nucleotide binding]; other site 574521009865 salt bridge; other site 574521009866 sequence-specific DNA binding site [nucleotide binding]; other site 574521009867 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 574521009868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521009869 S-adenosylmethionine binding site [chemical binding]; other site 574521009870 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 574521009871 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 574521009872 putative active site [active] 574521009873 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 574521009874 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 574521009875 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 574521009876 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521009877 serine/threonine transporter SstT; Provisional; Region: PRK13628 574521009878 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 574521009879 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 574521009880 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 574521009881 galactarate dehydratase; Region: galactar-dH20; TIGR03248 574521009882 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 574521009883 Glucuronate isomerase; Region: UxaC; pfam02614 574521009884 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 574521009885 D-galactonate transporter; Region: 2A0114; TIGR00893 574521009886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521009887 putative substrate translocation pore; other site 574521009888 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 574521009889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521009890 DNA-binding site [nucleotide binding]; DNA binding site 574521009891 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 574521009892 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 574521009893 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 574521009894 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 574521009895 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 574521009896 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 574521009897 Predicted membrane protein [Function unknown]; Region: COG5393 574521009898 YqjK-like protein; Region: YqjK; pfam13997 574521009899 Predicted membrane protein [Function unknown]; Region: COG2259 574521009900 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 574521009901 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 574521009902 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 574521009903 putative dimer interface [polypeptide binding]; other site 574521009904 N-terminal domain interface [polypeptide binding]; other site 574521009905 putative substrate binding pocket (H-site) [chemical binding]; other site 574521009906 Predicted membrane protein [Function unknown]; Region: COG3152 574521009907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521009908 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 574521009909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 574521009910 dimerization interface [polypeptide binding]; other site 574521009911 Pirin-related protein [General function prediction only]; Region: COG1741 574521009912 Pirin; Region: Pirin; pfam02678 574521009913 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 574521009914 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 574521009915 serine transporter; Region: stp; TIGR00814 574521009916 L-serine dehydratase TdcG; Provisional; Region: PRK15040 574521009917 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 574521009918 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 574521009919 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 574521009920 homotrimer interaction site [polypeptide binding]; other site 574521009921 putative active site [active] 574521009922 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 574521009923 Pyruvate formate lyase 1; Region: PFL1; cd01678 574521009924 coenzyme A binding site [chemical binding]; other site 574521009925 active site 574521009926 catalytic residues [active] 574521009927 glycine loop; other site 574521009928 propionate/acetate kinase; Provisional; Region: PRK12379 574521009929 Acetokinase family; Region: Acetate_kinase; cl17229 574521009930 threonine/serine transporter TdcC; Provisional; Region: PRK13629 574521009931 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 574521009932 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 574521009933 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 574521009934 tetramer interface [polypeptide binding]; other site 574521009935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521009936 catalytic residue [active] 574521009937 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 574521009938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521009939 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 574521009940 putative substrate binding pocket [chemical binding]; other site 574521009941 putative dimerization interface [polypeptide binding]; other site 574521009942 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 574521009943 glycerate kinase I; Provisional; Region: PRK10342 574521009944 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 574521009945 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 574521009946 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 574521009947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521009948 D-galactonate transporter; Region: 2A0114; TIGR00893 574521009949 putative substrate translocation pore; other site 574521009950 galactarate dehydratase; Region: galactar-dH20; TIGR03248 574521009951 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 574521009952 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 574521009953 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 574521009954 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 574521009955 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 574521009956 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 574521009957 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 574521009958 active site 574521009959 phosphorylation site [posttranslational modification] 574521009960 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 574521009961 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 574521009962 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 574521009963 active pocket/dimerization site; other site 574521009964 active site 574521009965 phosphorylation site [posttranslational modification] 574521009966 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 574521009967 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 574521009968 active site 574521009969 dimer interface [polypeptide binding]; other site 574521009970 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 574521009971 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 574521009972 dimer interface [polypeptide binding]; other site 574521009973 active site 574521009974 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 574521009975 putative active site [active] 574521009976 tagatose-bisphosphate aldolase; Reviewed; Region: kbaY; PRK12738 574521009977 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 574521009978 active site 574521009979 intersubunit interface [polypeptide binding]; other site 574521009980 zinc binding site [ion binding]; other site 574521009981 Na+ binding site [ion binding]; other site 574521009982 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 574521009983 active site 574521009984 phosphorylation site [posttranslational modification] 574521009985 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 574521009986 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 574521009987 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 574521009988 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 574521009989 active site 574521009990 trimer interface [polypeptide binding]; other site 574521009991 allosteric site; other site 574521009992 active site lid [active] 574521009993 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 574521009994 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 574521009995 putative SAM binding site [chemical binding]; other site 574521009996 putative homodimer interface [polypeptide binding]; other site 574521009997 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 574521009998 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 574521009999 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 574521010000 putative ligand binding site [chemical binding]; other site 574521010001 TIGR00252 family protein; Region: TIGR00252 574521010002 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 574521010003 dimer interface [polypeptide binding]; other site 574521010004 active site 574521010005 outer membrane lipoprotein; Provisional; Region: PRK11023 574521010006 BON domain; Region: BON; pfam04972 574521010007 BON domain; Region: BON; pfam04972 574521010008 Predicted permease; Region: DUF318; pfam03773 574521010009 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 574521010010 NADH(P)-binding; Region: NAD_binding_10; pfam13460 574521010011 NAD binding site [chemical binding]; other site 574521010012 active site 574521010013 hypothetical protein; Provisional; Region: PRK03467 574521010014 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 574521010015 GIY-YIG motif/motif A; other site 574521010016 putative active site [active] 574521010017 putative metal binding site [ion binding]; other site 574521010018 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 574521010019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521010020 Coenzyme A binding pocket [chemical binding]; other site 574521010021 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 574521010022 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 574521010023 Peptidase family U32; Region: Peptidase_U32; pfam01136 574521010024 putative protease; Provisional; Region: PRK15447 574521010025 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 574521010026 hypothetical protein; Provisional; Region: PRK10508 574521010027 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 574521010028 tryptophan permease; Provisional; Region: PRK10483 574521010029 aromatic amino acid transport protein; Region: araaP; TIGR00837 574521010030 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 574521010031 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 574521010032 ATP binding site [chemical binding]; other site 574521010033 Mg++ binding site [ion binding]; other site 574521010034 motif III; other site 574521010035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521010036 nucleotide binding region [chemical binding]; other site 574521010037 ATP-binding site [chemical binding]; other site 574521010038 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 574521010039 putative RNA binding site [nucleotide binding]; other site 574521010040 lipoprotein NlpI; Provisional; Region: PRK11189 574521010041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 574521010042 binding surface 574521010043 TPR motif; other site 574521010044 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 574521010045 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 574521010046 RNase E interface [polypeptide binding]; other site 574521010047 trimer interface [polypeptide binding]; other site 574521010048 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 574521010049 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 574521010050 RNase E interface [polypeptide binding]; other site 574521010051 trimer interface [polypeptide binding]; other site 574521010052 active site 574521010053 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 574521010054 putative nucleic acid binding region [nucleotide binding]; other site 574521010055 G-X-X-G motif; other site 574521010056 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 574521010057 RNA binding site [nucleotide binding]; other site 574521010058 domain interface; other site 574521010059 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 574521010060 16S/18S rRNA binding site [nucleotide binding]; other site 574521010061 S13e-L30e interaction site [polypeptide binding]; other site 574521010062 25S rRNA binding site [nucleotide binding]; other site 574521010063 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 574521010064 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 574521010065 RNA binding site [nucleotide binding]; other site 574521010066 active site 574521010067 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 574521010068 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 574521010069 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 574521010070 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 574521010071 translation initiation factor IF-2; Region: IF-2; TIGR00487 574521010072 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 574521010073 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 574521010074 G1 box; other site 574521010075 putative GEF interaction site [polypeptide binding]; other site 574521010076 GTP/Mg2+ binding site [chemical binding]; other site 574521010077 Switch I region; other site 574521010078 G2 box; other site 574521010079 G3 box; other site 574521010080 Switch II region; other site 574521010081 G4 box; other site 574521010082 G5 box; other site 574521010083 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 574521010084 Translation-initiation factor 2; Region: IF-2; pfam11987 574521010085 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 574521010086 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 574521010087 NusA N-terminal domain; Region: NusA_N; pfam08529 574521010088 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 574521010089 RNA binding site [nucleotide binding]; other site 574521010090 homodimer interface [polypeptide binding]; other site 574521010091 NusA-like KH domain; Region: KH_5; pfam13184 574521010092 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 574521010093 G-X-X-G motif; other site 574521010094 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 574521010095 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 574521010096 ribosome maturation protein RimP; Reviewed; Region: PRK00092 574521010097 hypothetical protein; Provisional; Region: PRK14641 574521010098 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 574521010099 putative oligomer interface [polypeptide binding]; other site 574521010100 putative RNA binding site [nucleotide binding]; other site 574521010101 argininosuccinate synthase; Validated; Region: PRK05370 574521010102 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 574521010103 Sulfatase; Region: Sulfatase; pfam00884 574521010104 Preprotein translocase SecG subunit; Region: SecG; pfam03840 574521010105 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 574521010106 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 574521010107 active site 574521010108 substrate binding site [chemical binding]; other site 574521010109 metal binding site [ion binding]; metal-binding site 574521010110 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 574521010111 dihydropteroate synthase; Region: DHPS; TIGR01496 574521010112 substrate binding pocket [chemical binding]; other site 574521010113 dimer interface [polypeptide binding]; other site 574521010114 inhibitor binding site; inhibition site 574521010115 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 574521010116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521010117 Walker A motif; other site 574521010118 ATP binding site [chemical binding]; other site 574521010119 Walker B motif; other site 574521010120 arginine finger; other site 574521010121 Peptidase family M41; Region: Peptidase_M41; pfam01434 574521010122 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 574521010123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521010124 S-adenosylmethionine binding site [chemical binding]; other site 574521010125 RNA-binding protein YhbY; Provisional; Region: PRK10343 574521010126 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 574521010127 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 574521010128 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 574521010129 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 574521010130 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 574521010131 GTPase CgtA; Reviewed; Region: obgE; PRK12298 574521010132 GTP1/OBG; Region: GTP1_OBG; pfam01018 574521010133 Obg GTPase; Region: Obg; cd01898 574521010134 G1 box; other site 574521010135 GTP/Mg2+ binding site [chemical binding]; other site 574521010136 Switch I region; other site 574521010137 G2 box; other site 574521010138 G3 box; other site 574521010139 Switch II region; other site 574521010140 G4 box; other site 574521010141 G5 box; other site 574521010142 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 574521010143 EamA-like transporter family; Region: EamA; pfam00892 574521010144 EamA-like transporter family; Region: EamA; cl17759 574521010145 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 574521010146 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 574521010147 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 574521010148 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 574521010149 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 574521010150 substrate binding pocket [chemical binding]; other site 574521010151 chain length determination region; other site 574521010152 substrate-Mg2+ binding site; other site 574521010153 catalytic residues [active] 574521010154 aspartate-rich region 1; other site 574521010155 active site lid residues [active] 574521010156 aspartate-rich region 2; other site 574521010157 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 574521010158 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 574521010159 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 574521010160 hinge; other site 574521010161 active site 574521010162 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 574521010163 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 574521010164 anti sigma factor interaction site; other site 574521010165 regulatory phosphorylation site [posttranslational modification]; other site 574521010166 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 574521010167 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 574521010168 mce related protein; Region: MCE; pfam02470 574521010169 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 574521010170 conserved hypothetical integral membrane protein; Region: TIGR00056 574521010171 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 574521010172 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 574521010173 Walker A/P-loop; other site 574521010174 ATP binding site [chemical binding]; other site 574521010175 Q-loop/lid; other site 574521010176 ABC transporter signature motif; other site 574521010177 Walker B; other site 574521010178 D-loop; other site 574521010179 H-loop/switch region; other site 574521010180 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 574521010181 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 574521010182 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 574521010183 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 574521010184 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 574521010185 putative active site [active] 574521010186 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 574521010187 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 574521010188 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 574521010189 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 574521010190 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 574521010191 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 574521010192 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 574521010193 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 574521010194 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 574521010195 Walker A/P-loop; other site 574521010196 ATP binding site [chemical binding]; other site 574521010197 Q-loop/lid; other site 574521010198 ABC transporter signature motif; other site 574521010199 Walker B; other site 574521010200 D-loop; other site 574521010201 H-loop/switch region; other site 574521010202 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 574521010203 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 574521010204 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 574521010205 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 574521010206 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 574521010207 30S subunit binding site; other site 574521010208 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 574521010209 active site 574521010210 phosphorylation site [posttranslational modification] 574521010211 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 574521010212 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 574521010213 dimerization domain swap beta strand [polypeptide binding]; other site 574521010214 regulatory protein interface [polypeptide binding]; other site 574521010215 active site 574521010216 regulatory phosphorylation site [posttranslational modification]; other site 574521010217 hypothetical protein; Provisional; Region: PRK10345 574521010218 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 574521010219 Transglycosylase; Region: Transgly; cl17702 574521010220 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 574521010221 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 574521010222 conserved cys residue [active] 574521010223 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 574521010224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 574521010225 putative active site [active] 574521010226 heme pocket [chemical binding]; other site 574521010227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521010228 dimer interface [polypeptide binding]; other site 574521010229 phosphorylation site [posttranslational modification] 574521010230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521010231 ATP binding site [chemical binding]; other site 574521010232 Mg2+ binding site [ion binding]; other site 574521010233 G-X-G motif; other site 574521010234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521010235 active site 574521010236 phosphorylation site [posttranslational modification] 574521010237 intermolecular recognition site; other site 574521010238 dimerization interface [polypeptide binding]; other site 574521010239 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 574521010240 putative binding surface; other site 574521010241 active site 574521010242 radical SAM protein, TIGR01212 family; Region: TIGR01212 574521010243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521010244 FeS/SAM binding site; other site 574521010245 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 574521010246 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 574521010247 active site 574521010248 dimer interface [polypeptide binding]; other site 574521010249 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 574521010250 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 574521010251 active site 574521010252 FMN binding site [chemical binding]; other site 574521010253 substrate binding site [chemical binding]; other site 574521010254 3Fe-4S cluster binding site [ion binding]; other site 574521010255 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 574521010256 domain interface; other site 574521010257 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 574521010258 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 574521010259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521010260 Domain of unknown function (DUF386); Region: DUF386; cl01047 574521010261 N-acetylmannosamine kinase; Provisional; Region: PRK05082 574521010262 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 574521010263 nucleotide binding site [chemical binding]; other site 574521010264 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 574521010265 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 574521010266 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 574521010267 putative active site cavity [active] 574521010268 putative sialic acid transporter; Provisional; Region: PRK03893 574521010269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521010270 putative substrate translocation pore; other site 574521010271 N-acetylneuraminate lyase; Region: nanA; TIGR00683 574521010272 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 574521010273 inhibitor site; inhibition site 574521010274 active site 574521010275 dimer interface [polypeptide binding]; other site 574521010276 catalytic residue [active] 574521010277 transcriptional regulator NanR; Provisional; Region: PRK03837 574521010278 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521010279 DNA-binding site [nucleotide binding]; DNA binding site 574521010280 FCD domain; Region: FCD; pfam07729 574521010281 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 574521010282 stringent starvation protein A; Provisional; Region: sspA; PRK09481 574521010283 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 574521010284 C-terminal domain interface [polypeptide binding]; other site 574521010285 putative GSH binding site (G-site) [chemical binding]; other site 574521010286 dimer interface [polypeptide binding]; other site 574521010287 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 574521010288 dimer interface [polypeptide binding]; other site 574521010289 N-terminal domain interface [polypeptide binding]; other site 574521010290 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 574521010291 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 574521010292 23S rRNA interface [nucleotide binding]; other site 574521010293 L3 interface [polypeptide binding]; other site 574521010294 Predicted ATPase [General function prediction only]; Region: COG1485 574521010295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 574521010296 hypothetical protein; Provisional; Region: PRK11677 574521010297 serine endoprotease; Provisional; Region: PRK10139 574521010298 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 574521010299 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 574521010300 protein binding site [polypeptide binding]; other site 574521010301 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 574521010302 serine endoprotease; Provisional; Region: PRK10898 574521010303 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 574521010304 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 574521010305 malate dehydrogenase; Provisional; Region: PRK05086 574521010306 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 574521010307 NAD binding site [chemical binding]; other site 574521010308 dimerization interface [polypeptide binding]; other site 574521010309 Substrate binding site [chemical binding]; other site 574521010310 arginine repressor; Provisional; Region: PRK05066 574521010311 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 574521010312 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 574521010313 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 574521010314 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 574521010315 RNAase interaction site [polypeptide binding]; other site 574521010316 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 574521010317 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 574521010318 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 574521010319 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521010320 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521010321 efflux system membrane protein; Provisional; Region: PRK11594 574521010322 transcriptional regulator; Provisional; Region: PRK10632 574521010323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521010324 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 574521010325 putative effector binding pocket; other site 574521010326 dimerization interface [polypeptide binding]; other site 574521010327 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521010328 protease TldD; Provisional; Region: tldD; PRK10735 574521010329 hypothetical protein; Provisional; Region: PRK10899 574521010330 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 574521010331 ribonuclease G; Provisional; Region: PRK11712 574521010332 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 574521010333 homodimer interface [polypeptide binding]; other site 574521010334 oligonucleotide binding site [chemical binding]; other site 574521010335 Maf-like protein; Region: Maf; pfam02545 574521010336 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 574521010337 active site 574521010338 dimer interface [polypeptide binding]; other site 574521010339 rod shape-determining protein MreD; Provisional; Region: PRK11060 574521010340 rod shape-determining protein MreC; Region: mreC; TIGR00219 574521010341 rod shape-determining protein MreC; Region: MreC; pfam04085 574521010342 rod shape-determining protein MreB; Provisional; Region: PRK13927 574521010343 MreB and similar proteins; Region: MreB_like; cd10225 574521010344 nucleotide binding site [chemical binding]; other site 574521010345 Mg binding site [ion binding]; other site 574521010346 putative protofilament interaction site [polypeptide binding]; other site 574521010347 RodZ interaction site [polypeptide binding]; other site 574521010348 regulatory protein CsrD; Provisional; Region: PRK11059 574521010349 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 574521010350 metal binding site [ion binding]; metal-binding site 574521010351 active site 574521010352 I-site; other site 574521010353 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521010354 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 574521010355 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 574521010356 NADP binding site [chemical binding]; other site 574521010357 dimer interface [polypeptide binding]; other site 574521010358 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 574521010359 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 574521010360 carboxyltransferase (CT) interaction site; other site 574521010361 biotinylation site [posttranslational modification]; other site 574521010362 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 574521010363 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 574521010364 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 574521010365 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 574521010366 hypothetical protein; Provisional; Region: PRK10633 574521010367 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 574521010368 Na binding site [ion binding]; other site 574521010369 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 574521010370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 574521010371 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 574521010372 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 574521010373 FMN binding site [chemical binding]; other site 574521010374 active site 574521010375 catalytic residues [active] 574521010376 substrate binding site [chemical binding]; other site 574521010377 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 574521010378 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 574521010379 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 574521010380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521010381 DNA methylase; Region: N6_N4_Mtase; pfam01555 574521010382 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 574521010383 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 574521010384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521010385 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 574521010386 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 574521010387 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521010388 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521010389 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 574521010390 Protein export membrane protein; Region: SecD_SecF; cl14618 574521010391 Protein export membrane protein; Region: SecD_SecF; cl14618 574521010392 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 574521010393 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 574521010394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521010395 substrate binding pocket [chemical binding]; other site 574521010396 membrane-bound complex binding site; other site 574521010397 hinge residues; other site 574521010398 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 574521010399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521010400 conserved gate region; other site 574521010401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521010402 dimer interface [polypeptide binding]; other site 574521010403 conserved gate region; other site 574521010404 putative PBP binding loops; other site 574521010405 ABC-ATPase subunit interface; other site 574521010406 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 574521010407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521010408 dimer interface [polypeptide binding]; other site 574521010409 conserved gate region; other site 574521010410 putative PBP binding loops; other site 574521010411 ABC-ATPase subunit interface; other site 574521010412 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 574521010413 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 574521010414 Walker A/P-loop; other site 574521010415 ATP binding site [chemical binding]; other site 574521010416 Q-loop/lid; other site 574521010417 ABC transporter signature motif; other site 574521010418 Walker B; other site 574521010419 D-loop; other site 574521010420 H-loop/switch region; other site 574521010421 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 574521010422 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 574521010423 trimer interface [polypeptide binding]; other site 574521010424 putative metal binding site [ion binding]; other site 574521010425 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 574521010426 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 574521010427 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 574521010428 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 574521010429 shikimate binding site; other site 574521010430 NAD(P) binding site [chemical binding]; other site 574521010431 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 574521010432 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 574521010433 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 574521010434 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 574521010435 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 574521010436 hypothetical protein; Validated; Region: PRK03430 574521010437 hypothetical protein; Provisional; Region: PRK10736 574521010438 DNA protecting protein DprA; Region: dprA; TIGR00732 574521010439 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 574521010440 active site 574521010441 catalytic residues [active] 574521010442 metal binding site [ion binding]; metal-binding site 574521010443 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 574521010444 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 574521010445 putative active site [active] 574521010446 substrate binding site [chemical binding]; other site 574521010447 putative cosubstrate binding site; other site 574521010448 catalytic site [active] 574521010449 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 574521010450 substrate binding site [chemical binding]; other site 574521010451 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 574521010452 putative RNA binding site [nucleotide binding]; other site 574521010453 16S rRNA methyltransferase B; Provisional; Region: PRK10901 574521010454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521010455 S-adenosylmethionine binding site [chemical binding]; other site 574521010456 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 574521010457 TrkA-N domain; Region: TrkA_N; pfam02254 574521010458 TrkA-C domain; Region: TrkA_C; pfam02080 574521010459 TrkA-N domain; Region: TrkA_N; pfam02254 574521010460 TrkA-C domain; Region: TrkA_C; pfam02080 574521010461 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 574521010462 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 574521010463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 574521010464 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 574521010465 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 574521010466 DNA binding residues [nucleotide binding] 574521010467 dimer interface [polypeptide binding]; other site 574521010468 metal binding site [ion binding]; metal-binding site 574521010469 hypothetical protein; Provisional; Region: PRK10203 574521010470 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 574521010471 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 574521010472 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 574521010473 alphaNTD homodimer interface [polypeptide binding]; other site 574521010474 alphaNTD - beta interaction site [polypeptide binding]; other site 574521010475 alphaNTD - beta' interaction site [polypeptide binding]; other site 574521010476 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 574521010477 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 574521010478 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 574521010479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 574521010480 RNA binding surface [nucleotide binding]; other site 574521010481 30S ribosomal protein S11; Validated; Region: PRK05309 574521010482 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 574521010483 30S ribosomal protein S13; Region: bact_S13; TIGR03631 574521010484 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 574521010485 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 574521010486 SecY translocase; Region: SecY; pfam00344 574521010487 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 574521010488 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 574521010489 23S rRNA binding site [nucleotide binding]; other site 574521010490 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 574521010491 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 574521010492 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 574521010493 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 574521010494 23S rRNA interface [nucleotide binding]; other site 574521010495 5S rRNA interface [nucleotide binding]; other site 574521010496 L27 interface [polypeptide binding]; other site 574521010497 L5 interface [polypeptide binding]; other site 574521010498 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 574521010499 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 574521010500 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 574521010501 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 574521010502 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 574521010503 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 574521010504 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 574521010505 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 574521010506 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 574521010507 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 574521010508 RNA binding site [nucleotide binding]; other site 574521010509 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 574521010510 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 574521010511 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 574521010512 23S rRNA interface [nucleotide binding]; other site 574521010513 putative translocon interaction site; other site 574521010514 signal recognition particle (SRP54) interaction site; other site 574521010515 L23 interface [polypeptide binding]; other site 574521010516 trigger factor interaction site; other site 574521010517 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 574521010518 23S rRNA interface [nucleotide binding]; other site 574521010519 5S rRNA interface [nucleotide binding]; other site 574521010520 putative antibiotic binding site [chemical binding]; other site 574521010521 L25 interface [polypeptide binding]; other site 574521010522 L27 interface [polypeptide binding]; other site 574521010523 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 574521010524 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 574521010525 G-X-X-G motif; other site 574521010526 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 574521010527 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 574521010528 protein-rRNA interface [nucleotide binding]; other site 574521010529 putative translocon binding site; other site 574521010530 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 574521010531 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 574521010532 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 574521010533 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 574521010534 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 574521010535 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 574521010536 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 574521010537 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 574521010538 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 574521010539 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 574521010540 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 574521010541 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 574521010542 heme binding site [chemical binding]; other site 574521010543 ferroxidase pore; other site 574521010544 ferroxidase diiron center [ion binding]; other site 574521010545 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 574521010546 elongation factor Tu; Reviewed; Region: PRK00049 574521010547 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 574521010548 G1 box; other site 574521010549 GEF interaction site [polypeptide binding]; other site 574521010550 GTP/Mg2+ binding site [chemical binding]; other site 574521010551 Switch I region; other site 574521010552 G2 box; other site 574521010553 G3 box; other site 574521010554 Switch II region; other site 574521010555 G4 box; other site 574521010556 G5 box; other site 574521010557 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 574521010558 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 574521010559 Antibiotic Binding Site [chemical binding]; other site 574521010560 elongation factor G; Reviewed; Region: PRK00007 574521010561 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 574521010562 G1 box; other site 574521010563 putative GEF interaction site [polypeptide binding]; other site 574521010564 GTP/Mg2+ binding site [chemical binding]; other site 574521010565 Switch I region; other site 574521010566 G2 box; other site 574521010567 G3 box; other site 574521010568 Switch II region; other site 574521010569 G4 box; other site 574521010570 G5 box; other site 574521010571 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 574521010572 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 574521010573 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 574521010574 30S ribosomal protein S7; Validated; Region: PRK05302 574521010575 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 574521010576 S17 interaction site [polypeptide binding]; other site 574521010577 S8 interaction site; other site 574521010578 16S rRNA interaction site [nucleotide binding]; other site 574521010579 streptomycin interaction site [chemical binding]; other site 574521010580 23S rRNA interaction site [nucleotide binding]; other site 574521010581 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 574521010582 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 574521010583 sulfur relay protein TusC; Validated; Region: PRK00211 574521010584 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 574521010585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 574521010586 YheO-like PAS domain; Region: PAS_6; pfam08348 574521010587 HTH domain; Region: HTH_22; pfam13309 574521010588 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 574521010589 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 574521010590 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 574521010591 phi X174 lysis protein; Provisional; Region: PRK02793 574521010592 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 574521010593 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 574521010594 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 574521010595 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 574521010596 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 574521010597 TrkA-N domain; Region: TrkA_N; pfam02254 574521010598 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 574521010599 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 574521010600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521010601 Walker A/P-loop; other site 574521010602 ATP binding site [chemical binding]; other site 574521010603 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 574521010604 ABC transporter signature motif; other site 574521010605 Walker B; other site 574521010606 D-loop; other site 574521010607 ABC transporter; Region: ABC_tran_2; pfam12848 574521010608 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 574521010609 putative hydrolase; Provisional; Region: PRK10985 574521010610 hypothetical protein; Provisional; Region: PRK04966 574521010611 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 574521010612 active site 574521010613 hypothetical protein; Provisional; Region: PRK10738 574521010614 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 574521010615 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 574521010616 ligand binding site [chemical binding]; other site 574521010617 flexible hinge region; other site 574521010618 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 574521010619 putative switch regulator; other site 574521010620 non-specific DNA interactions [nucleotide binding]; other site 574521010621 DNA binding site [nucleotide binding] 574521010622 sequence specific DNA binding site [nucleotide binding]; other site 574521010623 putative cAMP binding site [chemical binding]; other site 574521010624 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 574521010625 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 574521010626 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 574521010627 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 574521010628 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 574521010629 inhibitor-cofactor binding pocket; inhibition site 574521010630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521010631 catalytic residue [active] 574521010632 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 574521010633 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 574521010634 glutamine binding [chemical binding]; other site 574521010635 catalytic triad [active] 574521010636 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 574521010637 cell filamentation protein Fic; Provisional; Region: PRK10347 574521010638 hypothetical protein; Provisional; Region: PRK10204 574521010639 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 574521010640 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 574521010641 substrate binding site [chemical binding]; other site 574521010642 putative transporter; Provisional; Region: PRK03699 574521010643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521010644 putative substrate translocation pore; other site 574521010645 nitrite reductase subunit NirD; Provisional; Region: PRK14989 574521010646 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521010647 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 574521010648 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 574521010649 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 574521010650 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 574521010651 nitrite transporter NirC; Provisional; Region: PRK11562 574521010652 siroheme synthase; Provisional; Region: cysG; PRK10637 574521010653 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 574521010654 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 574521010655 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 574521010656 active site 574521010657 SAM binding site [chemical binding]; other site 574521010658 homodimer interface [polypeptide binding]; other site 574521010659 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 574521010660 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 574521010661 Protein of unknown function; Region: YhfT; pfam10797 574521010662 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 574521010663 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 574521010664 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 574521010665 active site 574521010666 substrate binding pocket [chemical binding]; other site 574521010667 homodimer interaction site [polypeptide binding]; other site 574521010668 putative mutase; Provisional; Region: PRK12383 574521010669 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 574521010670 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 574521010671 dimer interface [polypeptide binding]; other site 574521010672 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 574521010673 active site 574521010674 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 574521010675 substrate binding site [chemical binding]; other site 574521010676 catalytic residue [active] 574521010677 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 574521010678 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 574521010679 active site 574521010680 HIGH motif; other site 574521010681 dimer interface [polypeptide binding]; other site 574521010682 KMSKS motif; other site 574521010683 phosphoglycolate phosphatase; Provisional; Region: PRK13222 574521010684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521010685 motif II; other site 574521010686 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 574521010687 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 574521010688 substrate binding site [chemical binding]; other site 574521010689 hexamer interface [polypeptide binding]; other site 574521010690 metal binding site [ion binding]; metal-binding site 574521010691 DNA adenine methylase; Provisional; Region: PRK10904 574521010692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 574521010693 cell division protein DamX; Validated; Region: PRK10905 574521010694 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 574521010695 active site 574521010696 dimer interface [polypeptide binding]; other site 574521010697 metal binding site [ion binding]; metal-binding site 574521010698 shikimate kinase; Reviewed; Region: aroK; PRK00131 574521010699 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 574521010700 ADP binding site [chemical binding]; other site 574521010701 magnesium binding site [ion binding]; other site 574521010702 putative shikimate binding site; other site 574521010703 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 574521010704 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 574521010705 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 574521010706 pseudogene, conserved protein, truncated by frameshift mutation 574521010707 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 574521010708 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 574521010709 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 574521010710 Transglycosylase; Region: Transgly; pfam00912 574521010711 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 574521010712 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 574521010713 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 574521010714 ADP-ribose binding site [chemical binding]; other site 574521010715 dimer interface [polypeptide binding]; other site 574521010716 active site 574521010717 nudix motif; other site 574521010718 metal binding site [ion binding]; metal-binding site 574521010719 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 574521010720 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 574521010721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521010722 motif II; other site 574521010723 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 574521010724 RNA binding surface [nucleotide binding]; other site 574521010725 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 574521010726 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 574521010727 dimerization interface [polypeptide binding]; other site 574521010728 domain crossover interface; other site 574521010729 redox-dependent activation switch; other site 574521010730 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 574521010731 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 574521010732 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 574521010733 active site 574521010734 substrate-binding site [chemical binding]; other site 574521010735 metal-binding site [ion binding] 574521010736 ATP binding site [chemical binding]; other site 574521010737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521010738 non-specific DNA binding site [nucleotide binding]; other site 574521010739 salt bridge; other site 574521010740 sequence-specific DNA binding site [nucleotide binding]; other site 574521010741 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 574521010742 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 574521010743 dimerization interface [polypeptide binding]; other site 574521010744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521010745 dimer interface [polypeptide binding]; other site 574521010746 phosphorylation site [posttranslational modification] 574521010747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521010748 ATP binding site [chemical binding]; other site 574521010749 G-X-G motif; other site 574521010750 osmolarity response regulator; Provisional; Region: ompR; PRK09468 574521010751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521010752 active site 574521010753 phosphorylation site [posttranslational modification] 574521010754 intermolecular recognition site; other site 574521010755 dimerization interface [polypeptide binding]; other site 574521010756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521010757 DNA binding site [nucleotide binding] 574521010758 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 574521010759 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 574521010760 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 574521010761 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 574521010762 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 574521010763 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 574521010764 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 574521010765 RNA binding site [nucleotide binding]; other site 574521010766 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 574521010767 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 574521010768 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 574521010769 G1 box; other site 574521010770 GTP/Mg2+ binding site [chemical binding]; other site 574521010771 Switch I region; other site 574521010772 G2 box; other site 574521010773 G3 box; other site 574521010774 Switch II region; other site 574521010775 G4 box; other site 574521010776 G5 box; other site 574521010777 Nucleoside recognition; Region: Gate; pfam07670 574521010778 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 574521010779 Nucleoside recognition; Region: Gate; pfam07670 574521010780 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 574521010781 putative transposase; Provisional; Region: PRK09857 574521010782 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 574521010783 carboxylesterase BioH; Provisional; Region: PRK10349 574521010784 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 574521010785 DNA utilization protein GntX; Provisional; Region: PRK11595 574521010786 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 574521010787 active site 574521010788 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 574521010789 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 574521010790 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 574521010791 high-affinity gluconate transporter; Provisional; Region: PRK14984 574521010792 gluconate transporter; Region: gntP; TIGR00791 574521010793 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 574521010794 4-alpha-glucanotransferase; Region: malQ; TIGR00217 574521010795 maltodextrin phosphorylase; Provisional; Region: PRK14985 574521010796 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 574521010797 homodimer interface [polypeptide binding]; other site 574521010798 active site pocket [active] 574521010799 transcriptional regulator MalT; Provisional; Region: PRK04841 574521010800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521010801 DNA binding residues [nucleotide binding] 574521010802 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 574521010803 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 574521010804 putative active site [active] 574521010805 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 574521010806 hypothetical protein; Reviewed; Region: PRK09588 574521010807 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 574521010808 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 574521010809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521010810 Walker A motif; other site 574521010811 ATP binding site [chemical binding]; other site 574521010812 Walker B motif; other site 574521010813 arginine finger; other site 574521010814 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 574521010815 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 574521010816 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 574521010817 intramembrane serine protease GlpG; Provisional; Region: PRK10907 574521010818 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 574521010819 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 574521010820 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 574521010821 active site residue [active] 574521010822 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 574521010823 pseudogene, membrane protein, truncated by frameshift mutation 574521010824 glycogen phosphorylase; Provisional; Region: PRK14986 574521010825 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 574521010826 homodimer interface [polypeptide binding]; other site 574521010827 active site pocket [active] 574521010828 glycogen synthase; Provisional; Region: glgA; PRK00654 574521010829 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 574521010830 ADP-binding pocket [chemical binding]; other site 574521010831 homodimer interface [polypeptide binding]; other site 574521010832 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 574521010833 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 574521010834 ligand binding site; other site 574521010835 oligomer interface; other site 574521010836 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 574521010837 sulfate 1 binding site; other site 574521010838 glycogen debranching enzyme; Provisional; Region: PRK03705 574521010839 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 574521010840 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 574521010841 active site 574521010842 catalytic site [active] 574521010843 glycogen branching enzyme; Provisional; Region: PRK05402 574521010844 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 574521010845 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 574521010846 active site 574521010847 catalytic site [active] 574521010848 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 574521010849 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 574521010850 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 574521010851 putative antibiotic transporter; Provisional; Region: PRK10739 574521010852 low affinity gluconate transporter; Provisional; Region: PRK10472 574521010853 gluconate transporter; Region: gntP; TIGR00791 574521010854 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 574521010855 ATP-binding site [chemical binding]; other site 574521010856 Gluconate-6-phosphate binding site [chemical binding]; other site 574521010857 Shikimate kinase; Region: SKI; pfam01202 574521010858 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 574521010859 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521010860 DNA binding site [nucleotide binding] 574521010861 domain linker motif; other site 574521010862 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 574521010863 putative ligand binding site [chemical binding]; other site 574521010864 putative dimerization interface [polypeptide binding]; other site 574521010865 Pirin-related protein [General function prediction only]; Region: COG1741 574521010866 Pirin; Region: Pirin; pfam02678 574521010867 putative oxidoreductase; Provisional; Region: PRK10206 574521010868 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 574521010869 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 574521010870 putative acetyltransferase YhhY; Provisional; Region: PRK10140 574521010871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521010872 Coenzyme A binding pocket [chemical binding]; other site 574521010873 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 574521010874 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 574521010875 hypothetical protein; Provisional; Region: PRK10350 574521010876 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 574521010877 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 574521010878 putative active site [active] 574521010879 catalytic site [active] 574521010880 putative metal binding site [ion binding]; other site 574521010881 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 574521010882 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 574521010883 Walker A/P-loop; other site 574521010884 ATP binding site [chemical binding]; other site 574521010885 Q-loop/lid; other site 574521010886 ABC transporter signature motif; other site 574521010887 Walker B; other site 574521010888 D-loop; other site 574521010889 H-loop/switch region; other site 574521010890 TOBE domain; Region: TOBE_2; pfam08402 574521010891 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 574521010892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521010893 dimer interface [polypeptide binding]; other site 574521010894 conserved gate region; other site 574521010895 putative PBP binding loops; other site 574521010896 ABC-ATPase subunit interface; other site 574521010897 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 574521010898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521010899 dimer interface [polypeptide binding]; other site 574521010900 conserved gate region; other site 574521010901 putative PBP binding loops; other site 574521010902 ABC-ATPase subunit interface; other site 574521010903 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 574521010904 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 574521010905 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 574521010906 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 574521010907 Walker A/P-loop; other site 574521010908 ATP binding site [chemical binding]; other site 574521010909 Q-loop/lid; other site 574521010910 ABC transporter signature motif; other site 574521010911 Walker B; other site 574521010912 D-loop; other site 574521010913 H-loop/switch region; other site 574521010914 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 574521010915 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 574521010916 Walker A/P-loop; other site 574521010917 ATP binding site [chemical binding]; other site 574521010918 Q-loop/lid; other site 574521010919 ABC transporter signature motif; other site 574521010920 Walker B; other site 574521010921 D-loop; other site 574521010922 H-loop/switch region; other site 574521010923 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 574521010924 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 574521010925 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 574521010926 TM-ABC transporter signature motif; other site 574521010927 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 574521010928 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 574521010929 TM-ABC transporter signature motif; other site 574521010930 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 574521010931 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 574521010932 dimerization interface [polypeptide binding]; other site 574521010933 ligand binding site [chemical binding]; other site 574521010934 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 574521010935 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 574521010936 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 574521010937 dimerization interface [polypeptide binding]; other site 574521010938 ligand binding site [chemical binding]; other site 574521010939 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 574521010940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 574521010941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 574521010942 DNA binding residues [nucleotide binding] 574521010943 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 574521010944 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 574521010945 cell division protein FtsE; Provisional; Region: PRK10908 574521010946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521010947 Walker A/P-loop; other site 574521010948 ATP binding site [chemical binding]; other site 574521010949 Q-loop/lid; other site 574521010950 ABC transporter signature motif; other site 574521010951 Walker B; other site 574521010952 D-loop; other site 574521010953 H-loop/switch region; other site 574521010954 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 574521010955 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 574521010956 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 574521010957 P loop; other site 574521010958 GTP binding site [chemical binding]; other site 574521010959 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 574521010960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521010961 S-adenosylmethionine binding site [chemical binding]; other site 574521010962 hypothetical protein; Provisional; Region: PRK10910 574521010963 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 574521010964 Predicted membrane protein [Function unknown]; Region: COG3714 574521010965 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 574521010966 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 574521010967 metal-binding site [ion binding] 574521010968 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 574521010969 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521010970 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 574521010971 CPxP motif; other site 574521010972 hypothetical protein; Provisional; Region: PRK11212 574521010973 hypothetical protein; Provisional; Region: PRK11615 574521010974 major facilitator superfamily transporter; Provisional; Region: PRK05122 574521010975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521010976 putative substrate translocation pore; other site 574521010977 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 574521010978 Domain of unknown function DUF20; Region: UPF0118; pfam01594 574521010979 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 574521010980 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 574521010981 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 574521010982 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 574521010983 substrate binding site [chemical binding]; other site 574521010984 nickel transporter permease NikB; Provisional; Region: PRK10352 574521010985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521010986 dimer interface [polypeptide binding]; other site 574521010987 conserved gate region; other site 574521010988 putative PBP binding loops; other site 574521010989 ABC-ATPase subunit interface; other site 574521010990 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 574521010991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521010992 dimer interface [polypeptide binding]; other site 574521010993 conserved gate region; other site 574521010994 putative PBP binding loops; other site 574521010995 ABC-ATPase subunit interface; other site 574521010996 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 574521010997 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521010998 Walker A/P-loop; other site 574521010999 ATP binding site [chemical binding]; other site 574521011000 Q-loop/lid; other site 574521011001 ABC transporter signature motif; other site 574521011002 Walker B; other site 574521011003 D-loop; other site 574521011004 H-loop/switch region; other site 574521011005 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 574521011006 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 574521011007 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521011008 Walker A/P-loop; other site 574521011009 ATP binding site [chemical binding]; other site 574521011010 Q-loop/lid; other site 574521011011 ABC transporter signature motif; other site 574521011012 Walker B; other site 574521011013 D-loop; other site 574521011014 H-loop/switch region; other site 574521011015 nickel responsive regulator; Provisional; Region: PRK02967 574521011016 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 574521011017 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 574521011018 HicB family; Region: HicB; pfam05534 574521011019 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 574521011020 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 574521011021 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 574521011022 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 574521011023 Walker A/P-loop; other site 574521011024 ATP binding site [chemical binding]; other site 574521011025 Q-loop/lid; other site 574521011026 ABC transporter signature motif; other site 574521011027 Walker B; other site 574521011028 D-loop; other site 574521011029 H-loop/switch region; other site 574521011030 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 574521011031 Walker A/P-loop; other site 574521011032 ATP binding site [chemical binding]; other site 574521011033 Q-loop/lid; other site 574521011034 ABC transporter signature motif; other site 574521011035 Walker B; other site 574521011036 D-loop; other site 574521011037 H-loop/switch region; other site 574521011038 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 574521011039 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 574521011040 HlyD family secretion protein; Region: HlyD; pfam00529 574521011041 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521011042 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521011043 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 574521011044 Predicted flavoproteins [General function prediction only]; Region: COG2081 574521011045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 574521011046 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 574521011047 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 574521011048 universal stress protein UspB; Provisional; Region: PRK04960 574521011049 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 574521011050 Ligand Binding Site [chemical binding]; other site 574521011051 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 574521011052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521011053 POT family; Region: PTR2; pfam00854 574521011054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521011055 S-adenosylmethionine binding site [chemical binding]; other site 574521011056 oligopeptidase A; Provisional; Region: PRK10911 574521011057 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 574521011058 active site 574521011059 Zn binding site [ion binding]; other site 574521011060 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 574521011061 glutathione reductase; Validated; Region: PRK06116 574521011062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 574521011063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521011064 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 574521011065 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 574521011066 ArsC family; Region: ArsC; pfam03960 574521011067 catalytic residues [active] 574521011068 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 574521011069 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 574521011070 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521011071 DNA binding residues [nucleotide binding] 574521011072 dimerization interface [polypeptide binding]; other site 574521011073 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 574521011074 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 574521011075 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 574521011076 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 574521011077 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 574521011078 N-terminal plug; other site 574521011079 ligand-binding site [chemical binding]; other site 574521011080 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 574521011081 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 574521011082 putative hemin binding site; other site 574521011083 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 574521011084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521011085 FeS/SAM binding site; other site 574521011086 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 574521011087 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 574521011088 NADH(P)-binding; Region: NAD_binding_10; pfam13460 574521011089 NAD(P) binding site [chemical binding]; other site 574521011090 putative active site [active] 574521011091 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 574521011092 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 574521011093 ABC-ATPase subunit interface; other site 574521011094 dimer interface [polypeptide binding]; other site 574521011095 putative PBP binding regions; other site 574521011096 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 574521011097 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 574521011098 Walker A/P-loop; other site 574521011099 ATP binding site [chemical binding]; other site 574521011100 Q-loop/lid; other site 574521011101 ABC transporter signature motif; other site 574521011102 Walker B; other site 574521011103 D-loop; other site 574521011104 H-loop/switch region; other site 574521011105 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 574521011106 MgtC family; Region: MgtC; pfam02308 574521011107 acid-resistance protein; Provisional; Region: hdeB; PRK11566 574521011108 acid-resistance protein; Provisional; Region: PRK10208 574521011109 acid-resistance membrane protein; Provisional; Region: PRK10209 574521011110 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 574521011111 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 574521011112 pyruvate kinase; Provisional; Region: PRK05826 574521011113 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 574521011114 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521011115 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521011116 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 574521011117 Protein export membrane protein; Region: SecD_SecF; cl14618 574521011118 transcriptional regulator YdeO; Provisional; Region: PRK09940 574521011119 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521011120 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 574521011121 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521011122 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 574521011123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521011124 catalytic residue [active] 574521011125 Haem-binding domain; Region: Haem_bd; pfam14376 574521011126 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 574521011127 trehalase; Provisional; Region: treF; PRK13270 574521011128 Trehalase; Region: Trehalase; pfam01204 574521011129 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 574521011130 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521011131 DNA binding residues [nucleotide binding] 574521011132 dimerization interface [polypeptide binding]; other site 574521011133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 574521011134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521011135 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 574521011136 putative effector binding pocket; other site 574521011137 putative dimerization interface [polypeptide binding]; other site 574521011138 inner membrane protein YhjD; Region: TIGR00766 574521011139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521011140 metabolite-proton symporter; Region: 2A0106; TIGR00883 574521011141 putative substrate translocation pore; other site 574521011142 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 574521011143 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 574521011144 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521011145 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 574521011146 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 574521011147 substrate binding site [chemical binding]; other site 574521011148 ATP binding site [chemical binding]; other site 574521011149 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 574521011150 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 574521011151 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 574521011152 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 574521011153 putative diguanylate cyclase; Provisional; Region: PRK13561 574521011154 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 574521011155 metal binding site [ion binding]; metal-binding site 574521011156 active site 574521011157 I-site; other site 574521011158 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521011159 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 574521011160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 574521011161 binding surface 574521011162 TPR motif; other site 574521011163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 574521011164 binding surface 574521011165 TPR motif; other site 574521011166 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 574521011167 endo-1,4-D-glucanase; Provisional; Region: PRK11097 574521011168 cellulose synthase regulator protein; Provisional; Region: PRK11114 574521011169 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 574521011170 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 574521011171 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 574521011172 DXD motif; other site 574521011173 PilZ domain; Region: PilZ; pfam07238 574521011174 cell division protein; Provisional; Region: PRK10037 574521011175 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 574521011176 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 574521011177 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 574521011178 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 574521011179 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 574521011180 Transposase IS200 like; Region: Y1_Tnp; pfam01797 574521011181 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 574521011182 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 574521011183 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 574521011184 serine transporter; Region: stp; TIGR00814 574521011185 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 574521011186 HipA-like N-terminal domain; Region: HipA_N; pfam07805 574521011187 HipA-like C-terminal domain; Region: HipA_C; pfam07804 574521011188 HipA N-terminal domain; Region: Couple_hipA; pfam13657 574521011189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521011190 non-specific DNA binding site [nucleotide binding]; other site 574521011191 salt bridge; other site 574521011192 sequence-specific DNA binding site [nucleotide binding]; other site 574521011193 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 574521011194 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521011195 Walker A/P-loop; other site 574521011196 ATP binding site [chemical binding]; other site 574521011197 Q-loop/lid; other site 574521011198 ABC transporter signature motif; other site 574521011199 Walker B; other site 574521011200 D-loop; other site 574521011201 H-loop/switch region; other site 574521011202 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 574521011203 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 574521011204 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521011205 Walker A/P-loop; other site 574521011206 ATP binding site [chemical binding]; other site 574521011207 Q-loop/lid; other site 574521011208 ABC transporter signature motif; other site 574521011209 Walker B; other site 574521011210 D-loop; other site 574521011211 H-loop/switch region; other site 574521011212 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 574521011213 dipeptide transporter; Provisional; Region: PRK10913 574521011214 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 574521011215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521011216 dimer interface [polypeptide binding]; other site 574521011217 conserved gate region; other site 574521011218 putative PBP binding loops; other site 574521011219 ABC-ATPase subunit interface; other site 574521011220 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 574521011221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521011222 dimer interface [polypeptide binding]; other site 574521011223 conserved gate region; other site 574521011224 putative PBP binding loops; other site 574521011225 ABC-ATPase subunit interface; other site 574521011226 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 574521011227 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 574521011228 peptide binding site [polypeptide binding]; other site 574521011229 phosphoethanolamine transferase; Provisional; Region: PRK11560 574521011230 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 574521011231 Sulfatase; Region: Sulfatase; pfam00884 574521011232 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 574521011233 Fimbrial protein; Region: Fimbrial; cl01416 574521011234 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 574521011235 PapC N-terminal domain; Region: PapC_N; pfam13954 574521011236 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 574521011237 PapC C-terminal domain; Region: PapC_C; pfam13953 574521011238 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 574521011239 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 574521011240 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 574521011241 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 574521011242 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 574521011243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521011244 putative substrate translocation pore; other site 574521011245 pseudogene, conserved protein, truncated by frameshift mutation 574521011246 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 574521011247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 574521011248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521011249 Coenzyme A binding pocket [chemical binding]; other site 574521011250 pseudogene, biotin sulfoxide reductase, truncated by internal deletion 574521011251 putative outer membrane lipoprotein; Provisional; Region: PRK10510 574521011252 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 574521011253 ligand binding site [chemical binding]; other site 574521011254 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 574521011255 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 574521011256 dimerization interface [polypeptide binding]; other site 574521011257 ligand binding site [chemical binding]; other site 574521011258 NADP binding site [chemical binding]; other site 574521011259 catalytic site [active] 574521011260 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 574521011261 Predicted transcriptional regulator [Transcription]; Region: COG2944 574521011262 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521011263 non-specific DNA binding site [nucleotide binding]; other site 574521011264 salt bridge; other site 574521011265 sequence-specific DNA binding site [nucleotide binding]; other site 574521011266 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 574521011267 DNA-binding site [nucleotide binding]; DNA binding site 574521011268 RNA-binding motif; other site 574521011269 small toxic polypeptide; Provisional; Region: PRK09759 574521011270 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 574521011271 DALR anticodon binding domain; Region: DALR_1; pfam05746 574521011272 anticodon binding site; other site 574521011273 tRNA binding surface [nucleotide binding]; other site 574521011274 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 574521011275 dimer interface [polypeptide binding]; other site 574521011276 motif 1; other site 574521011277 active site 574521011278 motif 2; other site 574521011279 motif 3; other site 574521011280 YsaB-like lipoprotein; Region: YsaB; pfam13983 574521011281 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 574521011282 Acyltransferase family; Region: Acyl_transf_3; pfam01757 574521011283 hypothetical protein; Provisional; Region: PRK11383 574521011284 yiaA/B two helix domain; Region: YiaAB; pfam05360 574521011285 yiaA/B two helix domain; Region: YiaAB; pfam05360 574521011286 hypothetical protein; Provisional; Region: PRK11403 574521011287 yiaA/B two helix domain; Region: YiaAB; pfam05360 574521011288 xylulokinase; Provisional; Region: PRK15027 574521011289 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 574521011290 N- and C-terminal domain interface [polypeptide binding]; other site 574521011291 active site 574521011292 MgATP binding site [chemical binding]; other site 574521011293 catalytic site [active] 574521011294 metal binding site [ion binding]; metal-binding site 574521011295 xylulose binding site [chemical binding]; other site 574521011296 homodimer interface [polypeptide binding]; other site 574521011297 xylose isomerase; Provisional; Region: PRK05474 574521011298 xylose isomerase; Region: xylose_isom_A; TIGR02630 574521011299 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 574521011300 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 574521011301 putative ligand binding site [chemical binding]; other site 574521011302 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 574521011303 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 574521011304 Walker A/P-loop; other site 574521011305 ATP binding site [chemical binding]; other site 574521011306 Q-loop/lid; other site 574521011307 ABC transporter signature motif; other site 574521011308 Walker B; other site 574521011309 D-loop; other site 574521011310 H-loop/switch region; other site 574521011311 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 574521011312 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 574521011313 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 574521011314 TM-ABC transporter signature motif; other site 574521011315 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 574521011316 putative dimerization interface [polypeptide binding]; other site 574521011317 Transcriptional regulators [Transcription]; Region: PurR; COG1609 574521011318 putative ligand binding site [chemical binding]; other site 574521011319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521011320 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 574521011321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521011322 hypothetical protein; Provisional; Region: PRK10356 574521011323 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 574521011324 alpha-amylase; Reviewed; Region: malS; PRK09505 574521011325 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 574521011326 active site 574521011327 catalytic site [active] 574521011328 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 574521011329 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 574521011330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521011331 homodimer interface [polypeptide binding]; other site 574521011332 catalytic residue [active] 574521011333 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 574521011334 Transcriptional regulator [Transcription]; Region: IclR; COG1414 574521011335 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 574521011336 Bacterial transcriptional regulator; Region: IclR; pfam01614 574521011337 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 574521011338 Domain of unknown function (DUF386); Region: DUF386; pfam04074 574521011339 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 574521011340 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 574521011341 DctM-like transporters; Region: DctM; pfam06808 574521011342 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 574521011343 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 574521011344 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 574521011345 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 574521011346 putative N- and C-terminal domain interface [polypeptide binding]; other site 574521011347 putative active site [active] 574521011348 MgATP binding site [chemical binding]; other site 574521011349 catalytic site [active] 574521011350 metal binding site [ion binding]; metal-binding site 574521011351 putative xylulose binding site [chemical binding]; other site 574521011352 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 574521011353 active site 574521011354 dimer interface [polypeptide binding]; other site 574521011355 magnesium binding site [ion binding]; other site 574521011356 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 574521011357 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 574521011358 AP (apurinic/apyrimidinic) site pocket; other site 574521011359 DNA interaction; other site 574521011360 Metal-binding active site; metal-binding site 574521011361 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 574521011362 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 574521011363 intersubunit interface [polypeptide binding]; other site 574521011364 active site 574521011365 Zn2+ binding site [ion binding]; other site 574521011366 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 574521011367 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 574521011368 NAD(P) binding site [chemical binding]; other site 574521011369 catalytic residues [active] 574521011370 Fic family protein [Function unknown]; Region: COG3177 574521011371 Fic/DOC family; Region: Fic; pfam02661 574521011372 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 574521011373 putative alcohol dehydrogenase; Provisional; Region: PRK09860 574521011374 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 574521011375 dimer interface [polypeptide binding]; other site 574521011376 active site 574521011377 metal binding site [ion binding]; metal-binding site 574521011378 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 574521011379 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 574521011380 G1 box; other site 574521011381 putative GEF interaction site [polypeptide binding]; other site 574521011382 GTP/Mg2+ binding site [chemical binding]; other site 574521011383 Switch I region; other site 574521011384 G2 box; other site 574521011385 G3 box; other site 574521011386 Switch II region; other site 574521011387 G4 box; other site 574521011388 G5 box; other site 574521011389 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 574521011390 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 574521011391 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 574521011392 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 574521011393 selenocysteine synthase; Provisional; Region: PRK04311 574521011394 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 574521011395 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 574521011396 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 574521011397 catalytic residue [active] 574521011398 putative glutathione S-transferase; Provisional; Region: PRK10357 574521011399 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 574521011400 putative C-terminal domain interface [polypeptide binding]; other site 574521011401 putative GSH binding site (G-site) [chemical binding]; other site 574521011402 putative dimer interface [polypeptide binding]; other site 574521011403 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 574521011404 dimer interface [polypeptide binding]; other site 574521011405 N-terminal domain interface [polypeptide binding]; other site 574521011406 putative substrate binding pocket (H-site) [chemical binding]; other site 574521011407 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 574521011408 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521011409 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521011410 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 574521011411 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 574521011412 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 574521011413 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 574521011414 active site 574521011415 P-loop; other site 574521011416 phosphorylation site [posttranslational modification] 574521011417 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 574521011418 active site 574521011419 phosphorylation site [posttranslational modification] 574521011420 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 574521011421 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 574521011422 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 574521011423 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 574521011424 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 574521011425 hypothetical protein; Provisional; Region: PRK11020 574521011426 pseudogene, C-ter part of conserved protein, contains a premature stop codon 574521011427 pseudogene, adhesin, truncated by frameshift mutation 574521011428 L-lactate permease; Provisional; Region: PRK10420 574521011429 glycolate transporter; Provisional; Region: PRK09695 574521011430 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 574521011431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521011432 DNA-binding site [nucleotide binding]; DNA binding site 574521011433 FCD domain; Region: FCD; pfam07729 574521011434 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 574521011435 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 574521011436 phosphate binding site [ion binding]; other site 574521011437 putative rRNA methylase; Provisional; Region: PRK10358 574521011438 serine acetyltransferase; Provisional; Region: cysE; PRK11132 574521011439 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 574521011440 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 574521011441 trimer interface [polypeptide binding]; other site 574521011442 active site 574521011443 substrate binding site [chemical binding]; other site 574521011444 CoA binding site [chemical binding]; other site 574521011445 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 574521011446 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 574521011447 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 574521011448 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 574521011449 SecA binding site; other site 574521011450 Preprotein binding site; other site 574521011451 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 574521011452 GSH binding site [chemical binding]; other site 574521011453 catalytic residues [active] 574521011454 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 574521011455 active site residue [active] 574521011456 phosphoglyceromutase; Provisional; Region: PRK05434 574521011457 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 574521011458 AmiB activator; Provisional; Region: PRK11637 574521011459 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 574521011460 Peptidase family M23; Region: Peptidase_M23; pfam01551 574521011461 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 574521011462 NodB motif; other site 574521011463 putative active site [active] 574521011464 putative catalytic site [active] 574521011465 Zn binding site [ion binding]; other site 574521011466 putative glycosyl transferase; Provisional; Region: PRK10073 574521011467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 574521011468 active site 574521011469 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 574521011470 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 574521011471 NAD(P) binding site [chemical binding]; other site 574521011472 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 574521011473 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 574521011474 substrate-cofactor binding pocket; other site 574521011475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521011476 catalytic residue [active] 574521011477 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 574521011478 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 574521011479 NADP binding site [chemical binding]; other site 574521011480 homopentamer interface [polypeptide binding]; other site 574521011481 substrate binding site [chemical binding]; other site 574521011482 active site 574521011483 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 574521011484 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 574521011485 putative active site [active] 574521011486 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 574521011487 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 574521011488 putative active site [active] 574521011489 O-antigen ligase RfaL; Provisional; Region: PRK15487 574521011490 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 574521011491 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 574521011492 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 574521011493 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 574521011494 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10359 574521011495 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 574521011496 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 574521011497 Ligand binding site; other site 574521011498 metal-binding site 574521011499 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 574521011500 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 574521011501 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 574521011502 Ligand binding site; other site 574521011503 metal-binding site 574521011504 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 574521011505 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 574521011506 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 574521011507 putative ADP-binding pocket [chemical binding]; other site 574521011508 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 574521011509 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 574521011510 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 574521011511 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 574521011512 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 574521011513 putative active site [active] 574521011514 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 574521011515 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 574521011516 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 574521011517 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 574521011518 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 574521011519 active site 574521011520 (T/H)XGH motif; other site 574521011521 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 574521011522 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 574521011523 DNA binding site [nucleotide binding] 574521011524 catalytic residue [active] 574521011525 H2TH interface [polypeptide binding]; other site 574521011526 putative catalytic residues [active] 574521011527 turnover-facilitating residue; other site 574521011528 intercalation triad [nucleotide binding]; other site 574521011529 8OG recognition residue [nucleotide binding]; other site 574521011530 putative reading head residues; other site 574521011531 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 574521011532 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 574521011533 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 574521011534 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 574521011535 hypothetical protein; Reviewed; Region: PRK00024 574521011536 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 574521011537 MPN+ (JAMM) motif; other site 574521011538 Zinc-binding site [ion binding]; other site 574521011539 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 574521011540 Flavoprotein; Region: Flavoprotein; pfam02441 574521011541 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 574521011542 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 574521011543 trimer interface [polypeptide binding]; other site 574521011544 active site 574521011545 division inhibitor protein; Provisional; Region: slmA; PRK09480 574521011546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521011547 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 574521011548 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 574521011549 putative active site [active] 574521011550 putative NTP binding site [chemical binding]; other site 574521011551 putative nucleic acid binding site [nucleotide binding]; other site 574521011552 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 574521011553 active site 574521011554 ribonuclease PH; Reviewed; Region: rph; PRK00173 574521011555 Ribonuclease PH; Region: RNase_PH_bact; cd11362 574521011556 hexamer interface [polypeptide binding]; other site 574521011557 active site 574521011558 hypothetical protein; Provisional; Region: PRK11820 574521011559 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 574521011560 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 574521011561 prophage E2348_PP12, P4-like 574521011562 integrase; Provisional; Region: PRK09692 574521011563 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 574521011564 active site 574521011565 Int/Topo IB signature motif; other site 574521011566 Peptidase family M41; Region: Peptidase_M41; pfam01434 574521011567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521011568 non-specific DNA binding site [nucleotide binding]; other site 574521011569 salt bridge; other site 574521011570 sequence-specific DNA binding site [nucleotide binding]; other site 574521011571 Domain of unknown function (DUF955); Region: DUF955; cl01076 574521011572 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 574521011573 Alginate lyase; Region: Alginate_lyase2; pfam08787 574521011574 D5 N terminal like; Region: D5_N; smart00885 574521011575 Phage associated DNA primase [General function prediction only]; Region: COG3378 574521011576 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 574521011577 BRO family, N-terminal domain; Region: Bro-N; cl10591 574521011578 Predicted membrane protein [Function unknown]; Region: COG2860 574521011579 UPF0126 domain; Region: UPF0126; pfam03458 574521011580 UPF0126 domain; Region: UPF0126; pfam03458 574521011581 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 574521011582 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 574521011583 nucleotide binding pocket [chemical binding]; other site 574521011584 K-X-D-G motif; other site 574521011585 catalytic site [active] 574521011586 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 574521011587 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 574521011588 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 574521011589 catalytic site [active] 574521011590 G-X2-G-X-G-K; other site 574521011591 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 574521011592 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 574521011593 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 574521011594 Zn2+ binding site [ion binding]; other site 574521011595 Mg2+ binding site [ion binding]; other site 574521011596 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 574521011597 synthetase active site [active] 574521011598 NTP binding site [chemical binding]; other site 574521011599 metal binding site [ion binding]; metal-binding site 574521011600 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 574521011601 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 574521011602 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 574521011603 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 574521011604 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 574521011605 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 574521011606 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 574521011607 generic binding surface II; other site 574521011608 ssDNA binding site; other site 574521011609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 574521011610 ATP binding site [chemical binding]; other site 574521011611 putative Mg++ binding site [ion binding]; other site 574521011612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521011613 nucleotide binding region [chemical binding]; other site 574521011614 ATP-binding site [chemical binding]; other site 574521011615 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 574521011616 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 574521011617 AsmA family; Region: AsmA; pfam05170 574521011618 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 574521011619 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 574521011620 fructokinase; Reviewed; Region: PRK09557 574521011621 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 574521011622 nucleotide binding site [chemical binding]; other site 574521011623 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 574521011624 intersubunit interface [polypeptide binding]; other site 574521011625 active site 574521011626 zinc binding site [ion binding]; other site 574521011627 Na+ binding site [ion binding]; other site 574521011628 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 574521011629 intersubunit interface [polypeptide binding]; other site 574521011630 active site 574521011631 zinc binding site [ion binding]; other site 574521011632 Na+ binding site [ion binding]; other site 574521011633 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 574521011634 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 574521011635 active site 574521011636 P-loop; other site 574521011637 phosphorylation site [posttranslational modification] 574521011638 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 574521011639 active site 574521011640 phosphorylation site [posttranslational modification] 574521011641 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 574521011642 HTH domain; Region: HTH_11; pfam08279 574521011643 Mga helix-turn-helix domain; Region: Mga; pfam05043 574521011644 PRD domain; Region: PRD; pfam00874 574521011645 PRD domain; Region: PRD; pfam00874 574521011646 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 574521011647 active site 574521011648 P-loop; other site 574521011649 phosphorylation site [posttranslational modification] 574521011650 putative alpha-glucosidase; Provisional; Region: PRK10658 574521011651 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 574521011652 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 574521011653 active site 574521011654 homotrimer interface [polypeptide binding]; other site 574521011655 catalytic site [active] 574521011656 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 574521011657 putative transporter; Provisional; Region: PRK11462 574521011658 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 574521011659 integrative element E2348_LEE 574521011660 type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498 574521011661 type III secretion apparatus needle protein; Region: III_needle; TIGR02105 574521011662 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 574521011663 Enterobacterial EspB protein; Region: EspB; pfam05802 574521011664 Uncharacterized conserved protein [Function unknown]; Region: COG5613 574521011665 EspA-like secreted protein; Region: EspA; pfam03433 574521011666 type III secretion system protein SsaL; Provisional; Region: PRK15345 574521011667 HrpJ-like domain; Region: HrpJ; cl15454 574521011668 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 574521011669 type III secretion system protein SsaD; Provisional; Region: PRK15367 574521011670 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 574521011671 LysM domain; Region: LysM; pfam01476 574521011672 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 574521011673 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 574521011674 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 574521011675 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 574521011676 Intimin C-type lectin domain; Region: Intimin_C; pfam07979 574521011677 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 574521011678 Translocated intimin receptor (Tir) N-terminus; Region: Tir_receptor_N; pfam07490 574521011679 Translocated intimin receptor (Tir) intimin-binding domain; Region: Tir_receptor_M; pfam03549 574521011680 Translocated intimin receptor (Tir) C-terminus; Region: Tir_receptor_C; pfam07489 574521011681 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 574521011682 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 574521011683 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 574521011684 Protein of unknown function (DUF1106); Region: DUF1106; pfam06523 574521011685 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 574521011686 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 574521011687 Walker A motif/ATP binding site; other site 574521011688 Walker B motif; other site 574521011689 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 574521011690 FHIPEP family; Region: FHIPEP; pfam00771 574521011691 SepZ; Region: SepZ; pfam06066 574521011692 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 574521011693 outer membrane secretin SsaC; Provisional; Region: PRK15346 574521011694 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 574521011695 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 574521011696 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 574521011697 Tetratricopeptide repeat; Region: TPR_3; pfam07720 574521011698 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 574521011699 negative regulator GrlR; Provisional; Region: PRK14051 574521011700 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 574521011701 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 574521011702 N-acetyl-D-glucosamine binding site [chemical binding]; other site 574521011703 catalytic residue [active] 574521011704 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 574521011705 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 574521011706 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 574521011707 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 574521011708 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 574521011709 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 574521011710 Type III secretion system filament chaperone CesA; Region: CesA; pfam11439 574521011711 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 574521011712 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 574521011713 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 574521011714 EspG protein; Region: EspG; pfam06872 574521011715 SdiA-regulated; Region: SdiA-regulated; cd09971 574521011716 SdiA-regulated; Region: SdiA-regulated; pfam06977 574521011717 putative active site [active] 574521011718 EamA-like transporter family; Region: EamA; pfam00892 574521011719 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 574521011720 EamA-like transporter family; Region: EamA; pfam00892 574521011721 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 574521011722 lipoprotein, YaeC family; Region: TIGR00363 574521011723 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 574521011724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521011725 putative substrate translocation pore; other site 574521011726 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 574521011727 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 574521011728 pseudogene,cryptic adenine deaminase, truncated by frameshift mutation 574521011729 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 574521011730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521011731 putative substrate translocation pore; other site 574521011732 regulatory protein UhpC; Provisional; Region: PRK11663 574521011733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521011734 putative substrate translocation pore; other site 574521011735 sensory histidine kinase UhpB; Provisional; Region: PRK11644 574521011736 MASE1; Region: MASE1; pfam05231 574521011737 Histidine kinase; Region: HisKA_3; pfam07730 574521011738 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 574521011739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521011740 active site 574521011741 phosphorylation site [posttranslational modification] 574521011742 intermolecular recognition site; other site 574521011743 dimerization interface [polypeptide binding]; other site 574521011744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521011745 DNA binding residues [nucleotide binding] 574521011746 dimerization interface [polypeptide binding]; other site 574521011747 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 574521011748 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 574521011749 putative valine binding site [chemical binding]; other site 574521011750 dimer interface [polypeptide binding]; other site 574521011751 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 574521011752 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 574521011753 PYR/PP interface [polypeptide binding]; other site 574521011754 dimer interface [polypeptide binding]; other site 574521011755 TPP binding site [chemical binding]; other site 574521011756 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 574521011757 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 574521011758 TPP-binding site [chemical binding]; other site 574521011759 dimer interface [polypeptide binding]; other site 574521011760 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 574521011761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521011762 putative substrate translocation pore; other site 574521011763 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 574521011764 Domain of unknown function (DUF202); Region: DUF202; pfam02656 574521011765 Predicted membrane protein [Function unknown]; Region: COG2149 574521011766 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 574521011767 Sulfatase; Region: Sulfatase; pfam00884 574521011768 putative transporter; Provisional; Region: PRK10484 574521011769 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 574521011770 Na binding site [ion binding]; other site 574521011771 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 574521011772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521011773 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 574521011774 putative transporter; Validated; Region: PRK03818 574521011775 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 574521011776 TrkA-C domain; Region: TrkA_C; pfam02080 574521011777 TrkA-C domain; Region: TrkA_C; pfam02080 574521011778 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 574521011779 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 574521011780 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 574521011781 putative dimer interface [polypeptide binding]; other site 574521011782 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 574521011783 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 574521011784 putative dimer interface [polypeptide binding]; other site 574521011785 hypothetical protein; Provisional; Region: PRK11616 574521011786 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 574521011787 putative oxidoreductase; Provisional; Region: PRK11445 574521011788 hypothetical protein; Provisional; Region: PRK07236 574521011789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521011790 D-galactonate transporter; Region: 2A0114; TIGR00893 574521011791 putative substrate translocation pore; other site 574521011792 pseudogene, galactonate dehydratase, disrupted by ISEc13 574521011793 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521011794 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 574521011795 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 574521011796 active site 574521011797 intersubunit interface [polypeptide binding]; other site 574521011798 catalytic residue [active] 574521011799 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 574521011800 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 574521011801 Transcriptional regulators [Transcription]; Region: FadR; COG2186 574521011802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521011803 DNA-binding site [nucleotide binding]; DNA binding site 574521011804 FCD domain; Region: FCD; pfam07729 574521011805 hypothetical protein; Provisional; Region: PRK10215 574521011806 sugar phosphate phosphatase; Provisional; Region: PRK10513 574521011807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521011808 active site 574521011809 motif I; other site 574521011810 motif II; other site 574521011811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521011812 hypothetical protein; Provisional; Region: PRK11426 574521011813 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 574521011814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521011815 Mg2+ binding site [ion binding]; other site 574521011816 G-X-G motif; other site 574521011817 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 574521011818 anchoring element; other site 574521011819 dimer interface [polypeptide binding]; other site 574521011820 ATP binding site [chemical binding]; other site 574521011821 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 574521011822 active site 574521011823 putative metal-binding site [ion binding]; other site 574521011824 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 574521011825 recF protein; Region: recf; TIGR00611 574521011826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521011827 Walker A/P-loop; other site 574521011828 ATP binding site [chemical binding]; other site 574521011829 Q-loop/lid; other site 574521011830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521011831 ABC transporter signature motif; other site 574521011832 Walker B; other site 574521011833 D-loop; other site 574521011834 H-loop/switch region; other site 574521011835 DNA polymerase III subunit beta; Validated; Region: PRK05643 574521011836 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 574521011837 putative DNA binding surface [nucleotide binding]; other site 574521011838 dimer interface [polypeptide binding]; other site 574521011839 beta-clamp/clamp loader binding surface; other site 574521011840 beta-clamp/translesion DNA polymerase binding surface; other site 574521011841 DnaA N-terminal domain; Region: DnaA_N; pfam11638 574521011842 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 574521011843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521011844 Walker A motif; other site 574521011845 ATP binding site [chemical binding]; other site 574521011846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 574521011847 Walker B motif; other site 574521011848 arginine finger; other site 574521011849 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 574521011850 DnaA box-binding interface [nucleotide binding]; other site 574521011851 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 574521011852 ribonuclease P; Reviewed; Region: rnpA; PRK01732 574521011853 membrane protein insertase; Provisional; Region: PRK01318 574521011854 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 574521011855 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 574521011856 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 574521011857 trmE is a tRNA modification GTPase; Region: trmE; cd04164 574521011858 G1 box; other site 574521011859 GTP/Mg2+ binding site [chemical binding]; other site 574521011860 Switch I region; other site 574521011861 G2 box; other site 574521011862 Switch II region; other site 574521011863 G3 box; other site 574521011864 G4 box; other site 574521011865 G5 box; other site 574521011866 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 574521011867 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 574521011868 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 574521011869 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 574521011870 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 574521011871 catalytic residue [active] 574521011872 tryptophan permease TnaB; Provisional; Region: PRK09664 574521011873 aromatic amino acid transport protein; Region: araaP; TIGR00837 574521011874 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 574521011875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521011876 putative substrate translocation pore; other site 574521011877 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 574521011878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521011879 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 574521011880 substrate binding pocket [chemical binding]; other site 574521011881 dimerization interface [polypeptide binding]; other site 574521011882 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 574521011883 Predicted flavoprotein [General function prediction only]; Region: COG0431 574521011884 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 574521011885 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 574521011886 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 574521011887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521011888 active site 574521011889 motif I; other site 574521011890 motif II; other site 574521011891 putative inner membrane protein; Provisional; Region: PRK09823 574521011892 pseudogene, 6-phosphogluconolactonase, truncated by premature stop codon 574521011893 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 574521011894 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 574521011895 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 574521011896 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 574521011897 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 574521011898 trimer interface; other site 574521011899 sugar binding site [chemical binding]; other site 574521011900 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 574521011901 beta-galactosidase; Region: BGL; TIGR03356 574521011902 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 574521011903 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 574521011904 active site turn [active] 574521011905 phosphorylation site [posttranslational modification] 574521011906 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 574521011907 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 574521011908 HPr interaction site; other site 574521011909 glycerol kinase (GK) interaction site [polypeptide binding]; other site 574521011910 active site 574521011911 phosphorylation site [posttranslational modification] 574521011912 transcriptional antiterminator BglG; Provisional; Region: PRK09772 574521011913 CAT RNA binding domain; Region: CAT_RBD; pfam03123 574521011914 PRD domain; Region: PRD; pfam00874 574521011915 PRD domain; Region: PRD; pfam00874 574521011916 transcriptional regulator PhoU; Provisional; Region: PRK11115 574521011917 PhoU domain; Region: PhoU; pfam01895 574521011918 PhoU domain; Region: PhoU; pfam01895 574521011919 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 574521011920 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 574521011921 Walker A/P-loop; other site 574521011922 ATP binding site [chemical binding]; other site 574521011923 Q-loop/lid; other site 574521011924 ABC transporter signature motif; other site 574521011925 Walker B; other site 574521011926 D-loop; other site 574521011927 H-loop/switch region; other site 574521011928 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 574521011929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521011930 dimer interface [polypeptide binding]; other site 574521011931 conserved gate region; other site 574521011932 putative PBP binding loops; other site 574521011933 ABC-ATPase subunit interface; other site 574521011934 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 574521011935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521011936 dimer interface [polypeptide binding]; other site 574521011937 conserved gate region; other site 574521011938 putative PBP binding loops; other site 574521011939 ABC-ATPase subunit interface; other site 574521011940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521011941 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 574521011942 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 574521011943 glutaminase active site [active] 574521011944 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 574521011945 dimer interface [polypeptide binding]; other site 574521011946 active site 574521011947 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 574521011948 dimer interface [polypeptide binding]; other site 574521011949 active site 574521011950 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 574521011951 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 574521011952 Substrate binding site; other site 574521011953 Mg++ binding site; other site 574521011954 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 574521011955 active site 574521011956 substrate binding site [chemical binding]; other site 574521011957 CoA binding site [chemical binding]; other site 574521011958 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 574521011959 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 574521011960 gamma subunit interface [polypeptide binding]; other site 574521011961 epsilon subunit interface [polypeptide binding]; other site 574521011962 LBP interface [polypeptide binding]; other site 574521011963 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 574521011964 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 574521011965 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 574521011966 alpha subunit interaction interface [polypeptide binding]; other site 574521011967 Walker A motif; other site 574521011968 ATP binding site [chemical binding]; other site 574521011969 Walker B motif; other site 574521011970 inhibitor binding site; inhibition site 574521011971 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 574521011972 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 574521011973 core domain interface [polypeptide binding]; other site 574521011974 delta subunit interface [polypeptide binding]; other site 574521011975 epsilon subunit interface [polypeptide binding]; other site 574521011976 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 574521011977 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 574521011978 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 574521011979 beta subunit interaction interface [polypeptide binding]; other site 574521011980 Walker A motif; other site 574521011981 ATP binding site [chemical binding]; other site 574521011982 Walker B motif; other site 574521011983 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 574521011984 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 574521011985 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 574521011986 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 574521011987 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 574521011988 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 574521011989 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 574521011990 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 574521011991 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 574521011992 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 574521011993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521011994 S-adenosylmethionine binding site [chemical binding]; other site 574521011995 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 574521011996 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 574521011997 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 574521011998 FMN-binding protein MioC; Provisional; Region: PRK09004 574521011999 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 574521012000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 574521012001 putative DNA binding site [nucleotide binding]; other site 574521012002 putative Zn2+ binding site [ion binding]; other site 574521012003 AsnC family; Region: AsnC_trans_reg; pfam01037 574521012004 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 574521012005 dimer interface [polypeptide binding]; other site 574521012006 active site 574521012007 hypothetical protein; Provisional; Region: yieM; PRK10997 574521012008 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 574521012009 metal ion-dependent adhesion site (MIDAS); other site 574521012010 regulatory ATPase RavA; Provisional; Region: PRK13531 574521012011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521012012 Walker A motif; other site 574521012013 ATP binding site [chemical binding]; other site 574521012014 Walker B motif; other site 574521012015 arginine finger; other site 574521012016 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 574521012017 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 574521012018 potassium uptake protein; Region: kup; TIGR00794 574521012019 D-ribose pyranase; Provisional; Region: PRK11797 574521012020 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 574521012021 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 574521012022 Walker A/P-loop; other site 574521012023 ATP binding site [chemical binding]; other site 574521012024 Q-loop/lid; other site 574521012025 ABC transporter signature motif; other site 574521012026 Walker B; other site 574521012027 D-loop; other site 574521012028 H-loop/switch region; other site 574521012029 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 574521012030 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 574521012031 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 574521012032 TM-ABC transporter signature motif; other site 574521012033 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 574521012034 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 574521012035 ligand binding site [chemical binding]; other site 574521012036 dimerization interface [polypeptide binding]; other site 574521012037 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 574521012038 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 574521012039 substrate binding site [chemical binding]; other site 574521012040 dimer interface [polypeptide binding]; other site 574521012041 ATP binding site [chemical binding]; other site 574521012042 transcriptional repressor RbsR; Provisional; Region: PRK10423 574521012043 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521012044 DNA binding site [nucleotide binding] 574521012045 domain linker motif; other site 574521012046 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 574521012047 dimerization interface [polypeptide binding]; other site 574521012048 ligand binding site [chemical binding]; other site 574521012049 putative transporter; Provisional; Region: PRK10504 574521012050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521012051 putative substrate translocation pore; other site 574521012052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521012053 Transcriptional regulators [Transcription]; Region: FadR; COG2186 574521012054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521012055 DNA-binding site [nucleotide binding]; DNA binding site 574521012056 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 574521012057 transcriptional regulator HdfR; Provisional; Region: PRK03601 574521012058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521012059 LysR substrate binding domain; Region: LysR_substrate; pfam03466 574521012060 dimerization interface [polypeptide binding]; other site 574521012061 hypothetical protein; Provisional; Region: PRK11027 574521012062 putative ATP-dependent protease; Provisional; Region: PRK09862 574521012063 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 574521012064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521012065 Walker A motif; other site 574521012066 ATP binding site [chemical binding]; other site 574521012067 Walker B motif; other site 574521012068 arginine finger; other site 574521012069 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 574521012070 ilvG operon leader peptide; Provisional; Region: PRK10424 574521012071 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 574521012072 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 574521012073 PYR/PP interface [polypeptide binding]; other site 574521012074 dimer interface [polypeptide binding]; other site 574521012075 TPP binding site [chemical binding]; other site 574521012076 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 574521012077 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 574521012078 TPP-binding site [chemical binding]; other site 574521012079 dimer interface [polypeptide binding]; other site 574521012080 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 574521012081 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 574521012082 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 574521012083 homodimer interface [polypeptide binding]; other site 574521012084 substrate-cofactor binding pocket; other site 574521012085 catalytic residue [active] 574521012086 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 574521012087 threonine dehydratase; Reviewed; Region: PRK09224 574521012088 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 574521012089 tetramer interface [polypeptide binding]; other site 574521012090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521012091 catalytic residue [active] 574521012092 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 574521012093 putative Ile/Val binding site [chemical binding]; other site 574521012094 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 574521012095 putative Ile/Val binding site [chemical binding]; other site 574521012096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521012097 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 574521012098 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 574521012099 putative dimerization interface [polypeptide binding]; other site 574521012100 ketol-acid reductoisomerase; Validated; Region: PRK05225 574521012101 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 574521012102 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 574521012103 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 574521012104 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 574521012105 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 574521012106 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 574521012107 Part of AAA domain; Region: AAA_19; pfam13245 574521012108 Family description; Region: UvrD_C_2; pfam13538 574521012109 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 574521012110 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 574521012111 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 574521012112 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 574521012113 ATP binding site [chemical binding]; other site 574521012114 Mg++ binding site [ion binding]; other site 574521012115 motif III; other site 574521012116 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521012117 nucleotide binding region [chemical binding]; other site 574521012118 ATP-binding site [chemical binding]; other site 574521012119 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 574521012120 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 574521012121 catalytic residues [active] 574521012122 putative rho operon leader peptide; Provisional; Region: PRK09979 574521012123 transcription termination factor Rho; Provisional; Region: rho; PRK09376 574521012124 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 574521012125 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 574521012126 RNA binding site [nucleotide binding]; other site 574521012127 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 574521012128 multimer interface [polypeptide binding]; other site 574521012129 Walker A motif; other site 574521012130 ATP binding site [chemical binding]; other site 574521012131 Walker B motif; other site 574521012132 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 574521012133 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 574521012134 Mg++ binding site [ion binding]; other site 574521012135 putative catalytic motif [active] 574521012136 substrate binding site [chemical binding]; other site 574521012137 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 574521012138 Chain length determinant protein; Region: Wzz; pfam02706 574521012139 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 574521012140 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 574521012141 active site 574521012142 homodimer interface [polypeptide binding]; other site 574521012143 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 574521012144 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 574521012145 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 574521012146 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 574521012147 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 574521012148 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 574521012149 NAD binding site [chemical binding]; other site 574521012150 substrate binding site [chemical binding]; other site 574521012151 homodimer interface [polypeptide binding]; other site 574521012152 active site 574521012153 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 574521012154 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 574521012155 substrate binding site; other site 574521012156 tetramer interface; other site 574521012157 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 574521012158 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 574521012159 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 574521012160 inhibitor-cofactor binding pocket; inhibition site 574521012161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521012162 catalytic residue [active] 574521012163 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 574521012164 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 574521012165 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 574521012166 putative common antigen polymerase; Provisional; Region: PRK02975 574521012167 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 574521012168 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 574521012169 putative transport protein YifK; Provisional; Region: PRK10746 574521012170 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 574521012171 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521012172 FeS/SAM binding site; other site 574521012173 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 574521012174 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 574521012175 Sulfatase; Region: Sulfatase; pfam00884 574521012176 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 574521012177 HemY protein N-terminus; Region: HemY_N; pfam07219 574521012178 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 574521012179 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 574521012180 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 574521012181 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 574521012182 active site 574521012183 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 574521012184 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 574521012185 domain interfaces; other site 574521012186 active site 574521012187 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 574521012188 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 574521012189 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 574521012190 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 574521012191 putative iron binding site [ion binding]; other site 574521012192 DKNYY family; Region: DKNYY; pfam13644 574521012193 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 574521012194 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 574521012195 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 574521012196 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 574521012197 hypothetical protein; Provisional; Region: PRK10963 574521012198 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 574521012199 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 574521012200 active site 574521012201 DNA binding site [nucleotide binding] 574521012202 Int/Topo IB signature motif; other site 574521012203 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 574521012204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521012205 motif II; other site 574521012206 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 574521012207 Part of AAA domain; Region: AAA_19; pfam13245 574521012208 Family description; Region: UvrD_C_2; pfam13538 574521012209 Uncharacterized conserved protein [Function unknown]; Region: COG1912 574521012210 Predicted periplasmic protein [Function unknown]; Region: COG3698 574521012211 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 574521012212 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 574521012213 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 574521012214 Cl binding site [ion binding]; other site 574521012215 oligomer interface [polypeptide binding]; other site 574521012216 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 574521012217 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 574521012218 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 574521012219 EamA-like transporter family; Region: EamA; cl17759 574521012220 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 574521012221 CoenzymeA binding site [chemical binding]; other site 574521012222 subunit interaction site [polypeptide binding]; other site 574521012223 PHB binding site; other site 574521012224 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 574521012225 dimerization interface [polypeptide binding]; other site 574521012226 substrate binding site [chemical binding]; other site 574521012227 active site 574521012228 calcium binding site [ion binding]; other site 574521012229 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 574521012230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 574521012231 ATP binding site [chemical binding]; other site 574521012232 putative Mg++ binding site [ion binding]; other site 574521012233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521012234 nucleotide binding region [chemical binding]; other site 574521012235 ATP-binding site [chemical binding]; other site 574521012236 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 574521012237 Helicase and RNase D C-terminal; Region: HRDC; smart00341 574521012238 threonine efflux system; Provisional; Region: PRK10229 574521012239 putative transposase; Provisional; Region: PRK09857 574521012240 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 574521012241 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 574521012242 lysophospholipase L2; Provisional; Region: PRK10749 574521012243 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 574521012244 putative hydrolase; Provisional; Region: PRK10976 574521012245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521012246 active site 574521012247 motif I; other site 574521012248 motif II; other site 574521012249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521012250 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 574521012251 EamA-like transporter family; Region: EamA; pfam00892 574521012252 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 574521012253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521012254 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 574521012255 putative dimerization interface [polypeptide binding]; other site 574521012256 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 574521012257 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 574521012258 THF binding site; other site 574521012259 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 574521012260 substrate binding site [chemical binding]; other site 574521012261 THF binding site; other site 574521012262 zinc-binding site [ion binding]; other site 574521012263 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 574521012264 tetramer interface [polypeptide binding]; other site 574521012265 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 574521012266 active site 574521012267 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 574521012268 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 574521012269 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 574521012270 active site turn [active] 574521012271 phosphorylation site [posttranslational modification] 574521012272 transketolase; Reviewed; Region: PRK12753 574521012273 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 574521012274 TPP-binding site [chemical binding]; other site 574521012275 dimer interface [polypeptide binding]; other site 574521012276 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 574521012277 PYR/PP interface [polypeptide binding]; other site 574521012278 dimer interface [polypeptide binding]; other site 574521012279 TPP binding site [chemical binding]; other site 574521012280 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 574521012281 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 574521012282 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 574521012283 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 574521012284 putative active site [active] 574521012285 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 574521012286 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521012287 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 574521012288 dimerization interface [polypeptide binding]; other site 574521012289 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 574521012290 Na binding site [ion binding]; other site 574521012291 allophanate hydrolase; Provisional; Region: PRK08186 574521012292 carbamate kinase; Reviewed; Region: PRK12686 574521012293 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 574521012294 putative substrate binding site [chemical binding]; other site 574521012295 nucleotide binding site [chemical binding]; other site 574521012296 nucleotide binding site [chemical binding]; other site 574521012297 homodimer interface [polypeptide binding]; other site 574521012298 pseudogene, conserved protein, disrupted by ISEc13 574521012299 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521012300 membrane protein FdrA; Validated; Region: PRK06091 574521012301 CoA binding domain; Region: CoA_binding; pfam02629 574521012302 CoA-ligase; Region: Ligase_CoA; pfam00549 574521012303 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 574521012304 Isochorismatase family; Region: Isochorismatase; pfam00857 574521012305 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 574521012306 catalytic triad [active] 574521012307 conserved cis-peptide bond; other site 574521012308 Dienelactone hydrolase family; Region: DLH; pfam01738 574521012309 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 574521012310 uridine phosphorylase; Provisional; Region: PRK11178 574521012311 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 574521012312 DNA recombination protein RmuC; Provisional; Region: PRK10361 574521012313 RmuC family; Region: RmuC; pfam02646 574521012314 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 574521012315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521012316 S-adenosylmethionine binding site [chemical binding]; other site 574521012317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 574521012318 SCP-2 sterol transfer family; Region: SCP2; pfam02036 574521012319 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 574521012320 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 574521012321 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 574521012322 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 574521012323 sec-independent translocase; Provisional; Region: PRK01770 574521012324 sec-independent translocase; Provisional; Region: tatB; PRK00404 574521012325 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 574521012326 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 574521012327 active site 574521012328 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 574521012329 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 574521012330 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 574521012331 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 574521012332 FMN reductase; Validated; Region: fre; PRK08051 574521012333 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 574521012334 FAD binding pocket [chemical binding]; other site 574521012335 FAD binding motif [chemical binding]; other site 574521012336 phosphate binding motif [ion binding]; other site 574521012337 beta-alpha-beta structure motif; other site 574521012338 NAD binding pocket [chemical binding]; other site 574521012339 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 574521012340 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 574521012341 dimer interface [polypeptide binding]; other site 574521012342 active site 574521012343 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 574521012344 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 574521012345 substrate binding site [chemical binding]; other site 574521012346 oxyanion hole (OAH) forming residues; other site 574521012347 trimer interface [polypeptide binding]; other site 574521012348 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 574521012349 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 574521012350 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 574521012351 proline dipeptidase; Provisional; Region: PRK13607 574521012352 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 574521012353 active site 574521012354 hypothetical protein; Provisional; Region: PRK11568 574521012355 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 574521012356 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 574521012357 potassium transporter; Provisional; Region: PRK10750 574521012358 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 574521012359 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 574521012360 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 574521012361 Walker A motif; other site 574521012362 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 574521012363 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 574521012364 GTP binding site; other site 574521012365 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 574521012366 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 574521012367 serine/threonine protein kinase; Provisional; Region: PRK11768 574521012368 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 574521012369 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 574521012370 catalytic residues [active] 574521012371 hinge region; other site 574521012372 alpha helical domain; other site 574521012373 hypothetical protein; Provisional; Region: PRK11367 574521012374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 574521012375 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 574521012376 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 574521012377 putative acyl-acceptor binding pocket; other site 574521012378 DNA polymerase I; Provisional; Region: PRK05755 574521012379 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 574521012380 active site 574521012381 metal binding site 1 [ion binding]; metal-binding site 574521012382 putative 5' ssDNA interaction site; other site 574521012383 metal binding site 3; metal-binding site 574521012384 metal binding site 2 [ion binding]; metal-binding site 574521012385 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 574521012386 putative DNA binding site [nucleotide binding]; other site 574521012387 putative metal binding site [ion binding]; other site 574521012388 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 574521012389 active site 574521012390 catalytic site [active] 574521012391 substrate binding site [chemical binding]; other site 574521012392 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 574521012393 active site 574521012394 DNA binding site [nucleotide binding] 574521012395 catalytic site [active] 574521012396 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 574521012397 G1 box; other site 574521012398 GTP/Mg2+ binding site [chemical binding]; other site 574521012399 Switch I region; other site 574521012400 G2 box; other site 574521012401 G3 box; other site 574521012402 Switch II region; other site 574521012403 G4 box; other site 574521012404 G5 box; other site 574521012405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 574521012406 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 574521012407 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521012408 FeS/SAM binding site; other site 574521012409 HemN C-terminal domain; Region: HemN_C; pfam06969 574521012410 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 574521012411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521012412 active site 574521012413 phosphorylation site [posttranslational modification] 574521012414 intermolecular recognition site; other site 574521012415 dimerization interface [polypeptide binding]; other site 574521012416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521012417 Walker A motif; other site 574521012418 ATP binding site [chemical binding]; other site 574521012419 Walker B motif; other site 574521012420 arginine finger; other site 574521012421 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 574521012422 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 574521012423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 574521012424 putative active site [active] 574521012425 heme pocket [chemical binding]; other site 574521012426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521012427 dimer interface [polypeptide binding]; other site 574521012428 phosphorylation site [posttranslational modification] 574521012429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521012430 ATP binding site [chemical binding]; other site 574521012431 Mg2+ binding site [ion binding]; other site 574521012432 G-X-G motif; other site 574521012433 glutamine synthetase; Provisional; Region: glnA; PRK09469 574521012434 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 574521012435 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 574521012436 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 574521012437 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 574521012438 G1 box; other site 574521012439 putative GEF interaction site [polypeptide binding]; other site 574521012440 GTP/Mg2+ binding site [chemical binding]; other site 574521012441 Switch I region; other site 574521012442 G2 box; other site 574521012443 G3 box; other site 574521012444 Switch II region; other site 574521012445 G4 box; other site 574521012446 G5 box; other site 574521012447 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 574521012448 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 574521012449 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 574521012450 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 574521012451 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 574521012452 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 574521012453 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 574521012454 substrate binding site [chemical binding]; other site 574521012455 ATP binding site [chemical binding]; other site 574521012456 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 574521012457 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 574521012458 Class I aldolases; Region: Aldolase_Class_I; cl17187 574521012459 catalytic residue [active] 574521012460 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 574521012461 putative oxidoreductase; Provisional; Region: PRK10083 574521012462 NAD(P) binding site [chemical binding]; other site 574521012463 benzoate transport; Region: 2A0115; TIGR00895 574521012464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521012465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521012466 shikimate transporter; Provisional; Region: PRK09952 574521012467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521012468 putative substrate translocation pore; other site 574521012469 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 574521012470 active site 574521012471 catalytic residues [active] 574521012472 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 574521012473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521012474 motif II; other site 574521012475 hypothetical protein; Reviewed; Region: PRK01637 574521012476 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 574521012477 putative active site [active] 574521012478 dimerization interface [polypeptide binding]; other site 574521012479 putative tRNAtyr binding site [nucleotide binding]; other site 574521012480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521012481 Coenzyme A binding pocket [chemical binding]; other site 574521012482 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 574521012483 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 574521012484 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 574521012485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521012486 non-specific DNA binding site [nucleotide binding]; other site 574521012487 salt bridge; other site 574521012488 sequence-specific DNA binding site [nucleotide binding]; other site 574521012489 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 574521012490 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 574521012491 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 574521012492 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 574521012493 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 574521012494 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 574521012495 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 574521012496 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 574521012497 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 574521012498 [4Fe-4S] binding site [ion binding]; other site 574521012499 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 574521012500 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 574521012501 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 574521012502 molybdopterin cofactor binding site; other site 574521012503 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 574521012504 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 574521012505 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 574521012506 putative frv operon regulatory protein; Provisional; Region: PRK09863 574521012507 HTH domain; Region: HTH_11; pfam08279 574521012508 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 574521012509 active site 574521012510 phosphorylation site [posttranslational modification] 574521012511 putative peptidase; Provisional; Region: PRK09864 574521012512 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 574521012513 oligomer interface [polypeptide binding]; other site 574521012514 active site 574521012515 metal binding site [ion binding]; metal-binding site 574521012516 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 574521012517 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 574521012518 active site 574521012519 P-loop; other site 574521012520 phosphorylation site [posttranslational modification] 574521012521 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 574521012522 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 574521012523 active site 574521012524 phosphorylation site [posttranslational modification] 574521012525 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 574521012526 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 574521012527 intersubunit interface [polypeptide binding]; other site 574521012528 active site 574521012529 Zn2+ binding site [ion binding]; other site 574521012530 L-rhamnose isomerase; Provisional; Region: PRK01076 574521012531 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 574521012532 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 574521012533 N- and C-terminal domain interface [polypeptide binding]; other site 574521012534 active site 574521012535 putative catalytic site [active] 574521012536 metal binding site [ion binding]; metal-binding site 574521012537 ATP binding site [chemical binding]; other site 574521012538 rhamnulokinase; Provisional; Region: rhaB; PRK10640 574521012539 carbohydrate binding site [chemical binding]; other site 574521012540 transcriptional activator RhaS; Provisional; Region: PRK13503 574521012541 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 574521012542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521012543 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521012544 transcriptional activator RhaR; Provisional; Region: PRK13500 574521012545 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 574521012546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521012547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521012548 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 574521012549 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 574521012550 superoxide dismutase; Provisional; Region: PRK10925 574521012551 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 574521012552 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 574521012553 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 574521012554 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 574521012555 MOSC domain; Region: MOSC; pfam03473 574521012556 3-alpha domain; Region: 3-alpha; pfam03475 574521012557 two-component sensor protein; Provisional; Region: cpxA; PRK09470 574521012558 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 574521012559 dimerization interface [polypeptide binding]; other site 574521012560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521012561 dimer interface [polypeptide binding]; other site 574521012562 phosphorylation site [posttranslational modification] 574521012563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521012564 ATP binding site [chemical binding]; other site 574521012565 Mg2+ binding site [ion binding]; other site 574521012566 G-X-G motif; other site 574521012567 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 574521012568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521012569 active site 574521012570 intermolecular recognition site; other site 574521012571 dimerization interface [polypeptide binding]; other site 574521012572 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521012573 DNA binding site [nucleotide binding] 574521012574 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 574521012575 dimer interface [polypeptide binding]; other site 574521012576 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 574521012577 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 574521012578 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 574521012579 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 574521012580 active site 574521012581 ADP/pyrophosphate binding site [chemical binding]; other site 574521012582 dimerization interface [polypeptide binding]; other site 574521012583 allosteric effector site; other site 574521012584 fructose-1,6-bisphosphate binding site; other site 574521012585 sulfate transporter subunit; Provisional; Region: PRK10752 574521012586 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 574521012587 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 574521012588 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 574521012589 triosephosphate isomerase; Provisional; Region: PRK14567 574521012590 substrate binding site [chemical binding]; other site 574521012591 dimer interface [polypeptide binding]; other site 574521012592 catalytic triad [active] 574521012593 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 574521012594 Predicted membrane protein [Function unknown]; Region: COG3152 574521012595 hypothetical protein; Provisional; Region: PRK09981 574521012596 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 574521012597 Ligand Binding Site [chemical binding]; other site 574521012598 ferredoxin-NADP reductase; Provisional; Region: PRK10926 574521012599 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 574521012600 FAD binding pocket [chemical binding]; other site 574521012601 FAD binding motif [chemical binding]; other site 574521012602 phosphate binding motif [ion binding]; other site 574521012603 beta-alpha-beta structure motif; other site 574521012604 NAD binding pocket [chemical binding]; other site 574521012605 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 574521012606 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 574521012607 putative active site [active] 574521012608 glycerol kinase; Provisional; Region: glpK; PRK00047 574521012609 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 574521012610 N- and C-terminal domain interface [polypeptide binding]; other site 574521012611 active site 574521012612 MgATP binding site [chemical binding]; other site 574521012613 catalytic site [active] 574521012614 metal binding site [ion binding]; metal-binding site 574521012615 glycerol binding site [chemical binding]; other site 574521012616 homotetramer interface [polypeptide binding]; other site 574521012617 homodimer interface [polypeptide binding]; other site 574521012618 FBP binding site [chemical binding]; other site 574521012619 protein IIAGlc interface [polypeptide binding]; other site 574521012620 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 574521012621 amphipathic channel; other site 574521012622 Asn-Pro-Ala signature motifs; other site 574521012623 septal ring assembly protein ZapB; Provisional; Region: PRK15422 574521012624 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 574521012625 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 574521012626 UbiA prenyltransferase family; Region: UbiA; pfam01040 574521012627 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 574521012628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521012629 Walker A motif; other site 574521012630 ATP binding site [chemical binding]; other site 574521012631 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 574521012632 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 574521012633 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 574521012634 active site 574521012635 HslU subunit interaction site [polypeptide binding]; other site 574521012636 essential cell division protein FtsN; Provisional; Region: PRK10927 574521012637 cell division protein FtsN; Provisional; Region: PRK12757 574521012638 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521012639 DNA binding site [nucleotide binding] 574521012640 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 574521012641 domain linker motif; other site 574521012642 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 574521012643 dimerization interface [polypeptide binding]; other site 574521012644 ligand binding site [chemical binding]; other site 574521012645 primosome assembly protein PriA; Validated; Region: PRK05580 574521012646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 574521012647 ATP binding site [chemical binding]; other site 574521012648 putative Mg++ binding site [ion binding]; other site 574521012649 helicase superfamily c-terminal domain; Region: HELICc; smart00490 574521012650 ATP-binding site [chemical binding]; other site 574521012651 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 574521012652 hypothetical protein; Provisional; Region: PRK10030 574521012653 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 574521012654 dimerization interface [polypeptide binding]; other site 574521012655 DNA binding site [nucleotide binding] 574521012656 corepressor binding sites; other site 574521012657 cystathionine gamma-synthase; Provisional; Region: PRK08045 574521012658 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 574521012659 homodimer interface [polypeptide binding]; other site 574521012660 substrate-cofactor binding pocket; other site 574521012661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521012662 catalytic residue [active] 574521012663 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 574521012664 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 574521012665 putative catalytic residues [active] 574521012666 putative nucleotide binding site [chemical binding]; other site 574521012667 putative aspartate binding site [chemical binding]; other site 574521012668 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 574521012669 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 574521012670 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 574521012671 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 574521012672 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 574521012673 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 574521012674 active site 574521012675 metal binding site [ion binding]; metal-binding site 574521012676 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 574521012677 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 574521012678 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 574521012679 active site 574521012680 metal binding site [ion binding]; metal-binding site 574521012681 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 574521012682 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 574521012683 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 574521012684 active site 574521012685 metal binding site [ion binding]; metal-binding site 574521012686 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 574521012687 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 574521012688 FAD binding site [chemical binding]; other site 574521012689 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 574521012690 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 574521012691 heme binding site [chemical binding]; other site 574521012692 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 574521012693 EamA-like transporter family; Region: EamA; pfam00892 574521012694 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 574521012695 EamA-like transporter family; Region: EamA; pfam00892 574521012696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 574521012697 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 574521012698 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521012699 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521012700 pseudogene, N-ter part of transposase Orf2 of IS1397, disrupted by ISEc21 574521012701 Transposase; Region: DEDD_Tnp_IS110; pfam01548 574521012702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 574521012703 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 574521012704 pseudogene, C-ter part of transposase Orf2 of IS1397, disrupted by ISEc21 574521012705 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 574521012706 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 574521012707 dimer interface [polypeptide binding]; other site 574521012708 active site 574521012709 metal binding site [ion binding]; metal-binding site 574521012710 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 574521012711 active site 574521012712 intersubunit interactions; other site 574521012713 catalytic residue [active] 574521012714 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 574521012715 dimerization domain swap beta strand [polypeptide binding]; other site 574521012716 regulatory protein interface [polypeptide binding]; other site 574521012717 active site 574521012718 regulatory phosphorylation site [posttranslational modification]; other site 574521012719 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 574521012720 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 574521012721 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 574521012722 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 574521012723 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 574521012724 active site 574521012725 phosphorylation site [posttranslational modification] 574521012726 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 574521012727 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 574521012728 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 574521012729 active site 574521012730 P-loop; other site 574521012731 phosphorylation site [posttranslational modification] 574521012732 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 574521012733 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 574521012734 dimer interface [polypeptide binding]; other site 574521012735 active site 574521012736 glycine loop; other site 574521012737 pyruvate formate lyase II activase; Provisional; Region: PRK10076 574521012738 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 574521012739 active site 574521012740 P-loop; other site 574521012741 phosphorylation site [posttranslational modification] 574521012742 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 574521012743 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521012744 hypothetical protein; Provisional; Region: PRK10649 574521012745 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 574521012746 Sulfatase; Region: Sulfatase; pfam00884 574521012747 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 574521012748 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 574521012749 acetylornithine deacetylase; Provisional; Region: PRK05111 574521012750 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 574521012751 metal binding site [ion binding]; metal-binding site 574521012752 putative dimer interface [polypeptide binding]; other site 574521012753 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 574521012754 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 574521012755 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 574521012756 nucleotide binding site [chemical binding]; other site 574521012757 N-acetyl-L-glutamate binding site [chemical binding]; other site 574521012758 argininosuccinate lyase; Provisional; Region: PRK04833 574521012759 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 574521012760 active sites [active] 574521012761 tetramer interface [polypeptide binding]; other site 574521012762 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 574521012763 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 574521012764 putative active site pocket [active] 574521012765 putative metal binding site [ion binding]; other site 574521012766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521012767 D-galactonate transporter; Region: 2A0114; TIGR00893 574521012768 putative substrate translocation pore; other site 574521012769 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 574521012770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521012771 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 574521012772 dimerization interface [polypeptide binding]; other site 574521012773 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 574521012774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521012775 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 574521012776 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 574521012777 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 574521012778 metal binding site [ion binding]; metal-binding site 574521012779 putative dimer interface [polypeptide binding]; other site 574521012780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521012781 metabolite-proton symporter; Region: 2A0106; TIGR00883 574521012782 putative substrate translocation pore; other site 574521012783 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 574521012784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521012785 hypothetical protein; Provisional; Region: PRK11056 574521012786 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 574521012787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521012788 S-adenosylmethionine binding site [chemical binding]; other site 574521012789 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 574521012790 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 574521012791 N-terminal plug; other site 574521012792 ligand-binding site [chemical binding]; other site 574521012793 glutamate racemase; Provisional; Region: PRK00865 574521012794 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 574521012795 FAD binding domain; Region: FAD_binding_4; pfam01565 574521012796 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 574521012797 Biotin operon repressor [Transcription]; Region: BirA; COG1654 574521012798 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 574521012799 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 574521012800 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 574521012801 pantothenate kinase; Provisional; Region: PRK05439 574521012802 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 574521012803 ATP-binding site [chemical binding]; other site 574521012804 CoA-binding site [chemical binding]; other site 574521012805 Mg2+-binding site [ion binding]; other site 574521012806 elongation factor Tu; Reviewed; Region: PRK00049 574521012807 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 574521012808 G1 box; other site 574521012809 GEF interaction site [polypeptide binding]; other site 574521012810 GTP/Mg2+ binding site [chemical binding]; other site 574521012811 Switch I region; other site 574521012812 G2 box; other site 574521012813 G3 box; other site 574521012814 Switch II region; other site 574521012815 G4 box; other site 574521012816 G5 box; other site 574521012817 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 574521012818 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 574521012819 Antibiotic Binding Site [chemical binding]; other site 574521012820 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 574521012821 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 574521012822 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 574521012823 putative homodimer interface [polypeptide binding]; other site 574521012824 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 574521012825 heterodimer interface [polypeptide binding]; other site 574521012826 homodimer interface [polypeptide binding]; other site 574521012827 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 574521012828 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 574521012829 23S rRNA interface [nucleotide binding]; other site 574521012830 L7/L12 interface [polypeptide binding]; other site 574521012831 putative thiostrepton binding site; other site 574521012832 L25 interface [polypeptide binding]; other site 574521012833 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 574521012834 mRNA/rRNA interface [nucleotide binding]; other site 574521012835 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 574521012836 23S rRNA interface [nucleotide binding]; other site 574521012837 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 574521012838 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 574521012839 core dimer interface [polypeptide binding]; other site 574521012840 peripheral dimer interface [polypeptide binding]; other site 574521012841 L10 interface [polypeptide binding]; other site 574521012842 L11 interface [polypeptide binding]; other site 574521012843 putative EF-Tu interaction site [polypeptide binding]; other site 574521012844 putative EF-G interaction site [polypeptide binding]; other site 574521012845 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 574521012846 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 574521012847 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 574521012848 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 574521012849 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 574521012850 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 574521012851 RPB3 interaction site [polypeptide binding]; other site 574521012852 RPB1 interaction site [polypeptide binding]; other site 574521012853 RPB11 interaction site [polypeptide binding]; other site 574521012854 RPB10 interaction site [polypeptide binding]; other site 574521012855 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 574521012856 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 574521012857 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 574521012858 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 574521012859 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 574521012860 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 574521012861 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 574521012862 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 574521012863 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 574521012864 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 574521012865 DNA binding site [nucleotide binding] 574521012866 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 574521012867 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 574521012868 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521012869 FeS/SAM binding site; other site 574521012870 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 574521012871 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 574521012872 ThiS interaction site; other site 574521012873 putative active site [active] 574521012874 tetramer interface [polypeptide binding]; other site 574521012875 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 574521012876 thiS-thiF/thiG interaction site; other site 574521012877 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 574521012878 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 574521012879 ATP binding site [chemical binding]; other site 574521012880 substrate interface [chemical binding]; other site 574521012881 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 574521012882 thiamine phosphate binding site [chemical binding]; other site 574521012883 active site 574521012884 pyrophosphate binding site [ion binding]; other site 574521012885 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 574521012886 ThiC-associated domain; Region: ThiC-associated; pfam13667 574521012887 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 574521012888 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 574521012889 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 574521012890 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 574521012891 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 574521012892 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 574521012893 putative NADH binding site [chemical binding]; other site 574521012894 putative active site [active] 574521012895 nudix motif; other site 574521012896 putative metal binding site [ion binding]; other site 574521012897 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 574521012898 substrate binding site [chemical binding]; other site 574521012899 active site 574521012900 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 574521012901 Active_site [active] 574521012902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 574521012903 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 574521012904 IHF dimer interface [polypeptide binding]; other site 574521012905 IHF - DNA interface [nucleotide binding]; other site 574521012906 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 574521012907 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 574521012908 dimer interface [polypeptide binding]; other site 574521012909 sensor protein ZraS; Provisional; Region: PRK10364 574521012910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521012911 dimer interface [polypeptide binding]; other site 574521012912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521012913 ATP binding site [chemical binding]; other site 574521012914 Mg2+ binding site [ion binding]; other site 574521012915 G-X-G motif; other site 574521012916 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 574521012917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521012918 active site 574521012919 phosphorylation site [posttranslational modification] 574521012920 intermolecular recognition site; other site 574521012921 dimerization interface [polypeptide binding]; other site 574521012922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521012923 Walker A motif; other site 574521012924 ATP binding site [chemical binding]; other site 574521012925 Walker B motif; other site 574521012926 arginine finger; other site 574521012927 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 574521012928 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 574521012929 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 574521012930 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 574521012931 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 574521012932 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 574521012933 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 574521012934 purine monophosphate binding site [chemical binding]; other site 574521012935 dimer interface [polypeptide binding]; other site 574521012936 putative catalytic residues [active] 574521012937 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 574521012938 hypothetical protein; Provisional; Region: PRK10039 574521012939 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 574521012940 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521012941 Coenzyme A binding pocket [chemical binding]; other site 574521012942 homoserine O-succinyltransferase; Provisional; Region: PRK05368 574521012943 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 574521012944 proposed active site lysine [active] 574521012945 conserved cys residue [active] 574521012946 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 574521012947 malate synthase A; Region: malate_syn_A; TIGR01344 574521012948 active site 574521012949 isocitrate lyase; Provisional; Region: PRK15063 574521012950 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 574521012951 tetramer interface [polypeptide binding]; other site 574521012952 active site 574521012953 Mg2+/Mn2+ binding site [ion binding]; other site 574521012954 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 574521012955 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 574521012956 transcriptional repressor IclR; Provisional; Region: PRK11569 574521012957 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 574521012958 Bacterial transcriptional regulator; Region: IclR; pfam01614 574521012959 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 574521012960 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 574521012961 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 574521012962 substrate binding pocket [chemical binding]; other site 574521012963 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 574521012964 B12 binding site [chemical binding]; other site 574521012965 cobalt ligand [ion binding]; other site 574521012966 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 574521012967 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 574521012968 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 574521012969 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 574521012970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 574521012971 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521012972 Helix-turn-helix domain; Region: HTH_28; pfam13518 574521012973 pseudogene, N-ter part of transposase Orf1 of IS1397, disrupted by ISEc21 574521012974 Transposase; Region: DEDD_Tnp_IS110; pfam01548 574521012975 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 574521012976 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 574521012977 pseudogene, C-ter part of transposase Orf2 of IS1397, disrupted by ISEc21 574521012978 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 574521012979 active site pocket [active] 574521012980 oxyanion hole [active] 574521012981 catalytic triad [active] 574521012982 active site nucleophile [active] 574521012983 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 574521012984 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 574521012985 putative NAD(P) binding site [chemical binding]; other site 574521012986 catalytic Zn binding site [ion binding]; other site 574521012987 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 574521012988 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 574521012989 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 574521012990 active site 574521012991 phosphorylation site [posttranslational modification] 574521012992 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 574521012993 active pocket/dimerization site; other site 574521012994 active site 574521012995 phosphorylation site [posttranslational modification] 574521012996 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 574521012997 classical (c) SDRs; Region: SDR_c; cd05233 574521012998 NAD(P) binding site [chemical binding]; other site 574521012999 active site 574521013000 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 574521013001 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 574521013002 putative DNA binding site [nucleotide binding]; other site 574521013003 putative Zn2+ binding site [ion binding]; other site 574521013004 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 574521013005 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 574521013006 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 574521013007 RNA binding surface [nucleotide binding]; other site 574521013008 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 574521013009 probable active site [active] 574521013010 hypothetical protein; Provisional; Region: PRK10515 574521013011 aspartate kinase III; Validated; Region: PRK09084 574521013012 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 574521013013 nucleotide binding site [chemical binding]; other site 574521013014 substrate binding site [chemical binding]; other site 574521013015 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 574521013016 lysine allosteric regulatory site; other site 574521013017 dimer interface [polypeptide binding]; other site 574521013018 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 574521013019 dimer interface [polypeptide binding]; other site 574521013020 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 574521013021 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 574521013022 active site 574521013023 dimer interface [polypeptide binding]; other site 574521013024 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 574521013025 dimer interface [polypeptide binding]; other site 574521013026 active site 574521013027 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 574521013028 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 574521013029 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 574521013030 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 574521013031 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 574521013032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521013033 dimer interface [polypeptide binding]; other site 574521013034 conserved gate region; other site 574521013035 putative PBP binding loops; other site 574521013036 ABC-ATPase subunit interface; other site 574521013037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521013038 dimer interface [polypeptide binding]; other site 574521013039 conserved gate region; other site 574521013040 putative PBP binding loops; other site 574521013041 ABC-ATPase subunit interface; other site 574521013042 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 574521013043 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 574521013044 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 574521013045 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 574521013046 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 574521013047 Walker A/P-loop; other site 574521013048 ATP binding site [chemical binding]; other site 574521013049 Q-loop/lid; other site 574521013050 ABC transporter signature motif; other site 574521013051 Walker B; other site 574521013052 D-loop; other site 574521013053 H-loop/switch region; other site 574521013054 TOBE domain; Region: TOBE_2; pfam08402 574521013055 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 574521013056 trimer interface; other site 574521013057 sugar binding site [chemical binding]; other site 574521013058 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521013059 maltose regulon periplasmic protein; Provisional; Region: PRK10564 574521013060 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 574521013061 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 574521013062 UbiA prenyltransferase family; Region: UbiA; pfam01040 574521013063 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 574521013064 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 574521013065 putative acyl-acceptor binding pocket; other site 574521013066 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 574521013067 LexA repressor; Validated; Region: PRK00215 574521013068 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 574521013069 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 574521013070 Catalytic site [active] 574521013071 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 574521013072 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 574521013073 hypothetical protein; Provisional; Region: PRK10428 574521013074 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 574521013075 metal binding site 2 [ion binding]; metal-binding site 574521013076 putative DNA binding helix; other site 574521013077 metal binding site 1 [ion binding]; metal-binding site 574521013078 dimer interface [polypeptide binding]; other site 574521013079 structural Zn2+ binding site [ion binding]; other site 574521013080 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 574521013081 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 574521013082 FMN binding site [chemical binding]; other site 574521013083 active site 574521013084 catalytic residues [active] 574521013085 substrate binding site [chemical binding]; other site 574521013086 phage shock protein G; Reviewed; Region: pspG; PRK09459 574521013087 pseudogene, quinone oxidoreductase, NADPH-dependent, truncated by frameshift mutation (5-bp deletion) 574521013088 replicative DNA helicase; Provisional; Region: PRK08006 574521013089 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 574521013090 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 574521013091 Walker A motif; other site 574521013092 ATP binding site [chemical binding]; other site 574521013093 Walker B motif; other site 574521013094 DNA binding loops [nucleotide binding] 574521013095 alanine racemase; Reviewed; Region: alr; PRK00053 574521013096 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 574521013097 active site 574521013098 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 574521013099 substrate binding site [chemical binding]; other site 574521013100 catalytic residues [active] 574521013101 dimer interface [polypeptide binding]; other site 574521013102 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 574521013103 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 574521013104 active site 574521013105 (T/H)XGH motif; other site 574521013106 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 574521013107 AAA domain; Region: AAA_28; pfam13521 574521013108 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 574521013109 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 574521013110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521013111 homodimer interface [polypeptide binding]; other site 574521013112 catalytic residue [active] 574521013113 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 574521013114 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 574521013115 TPP-binding site [chemical binding]; other site 574521013116 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 574521013117 dimer interface [polypeptide binding]; other site 574521013118 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 574521013119 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 574521013120 E3 interaction surface; other site 574521013121 lipoyl attachment site [posttranslational modification]; other site 574521013122 e3 binding domain; Region: E3_binding; pfam02817 574521013123 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 574521013124 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 574521013125 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 574521013126 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 574521013127 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 574521013128 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 574521013129 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 574521013130 CoA-ligase; Region: Ligase_CoA; pfam00549 574521013131 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 574521013132 CoA binding domain; Region: CoA_binding; smart00881 574521013133 CoA-ligase; Region: Ligase_CoA; pfam00549 574521013134 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 574521013135 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 574521013136 transmembrane helices; other site 574521013137 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 574521013138 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 574521013139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521013140 active site 574521013141 phosphorylation site [posttranslational modification] 574521013142 intermolecular recognition site; other site 574521013143 dimerization interface [polypeptide binding]; other site 574521013144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521013145 Walker A motif; other site 574521013146 ATP binding site [chemical binding]; other site 574521013147 Walker B motif; other site 574521013148 arginine finger; other site 574521013149 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 574521013150 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 574521013151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521013152 dimer interface [polypeptide binding]; other site 574521013153 phosphorylation site [posttranslational modification] 574521013154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521013155 ATP binding site [chemical binding]; other site 574521013156 Mg2+ binding site [ion binding]; other site 574521013157 G-X-G motif; other site 574521013158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521013159 active site 574521013160 motif I; other site 574521013161 motif II; other site 574521013162 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 574521013163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 574521013164 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 574521013165 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 574521013166 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 574521013167 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 574521013168 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 574521013169 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 574521013170 dimer interface [polypeptide binding]; other site 574521013171 ssDNA binding site [nucleotide binding]; other site 574521013172 tetramer (dimer of dimers) interface [polypeptide binding]; other site 574521013173 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 574521013174 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 574521013175 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 574521013176 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 574521013177 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 574521013178 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521013179 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 574521013180 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 574521013181 DNA binding residues [nucleotide binding] 574521013182 dimer interface [polypeptide binding]; other site 574521013183 [2Fe-2S] cluster binding site [ion binding]; other site 574521013184 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 574521013185 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 574521013186 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 574521013187 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 574521013188 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 574521013189 Na binding site [ion binding]; other site 574521013190 Predicted membrane protein [Function unknown]; Region: COG3162 574521013191 acetyl-CoA synthetase; Provisional; Region: PRK00174 574521013192 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 574521013193 active site 574521013194 CoA binding site [chemical binding]; other site 574521013195 acyl-activating enzyme (AAE) consensus motif; other site 574521013196 AMP binding site [chemical binding]; other site 574521013197 acetate binding site [chemical binding]; other site 574521013198 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 574521013199 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 574521013200 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 574521013201 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 574521013202 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 574521013203 heme lyase subunit NrfE; Provisional; Region: PRK10369 574521013204 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 574521013205 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 574521013206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 574521013207 binding surface 574521013208 TPR motif; other site 574521013209 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 574521013210 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 574521013211 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 574521013212 Sel1-like repeats; Region: SEL1; smart00671 574521013213 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 574521013214 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521013215 Walker A/P-loop; other site 574521013216 ATP binding site [chemical binding]; other site 574521013217 Q-loop/lid; other site 574521013218 ABC transporter signature motif; other site 574521013219 Walker B; other site 574521013220 D-loop; other site 574521013221 H-loop/switch region; other site 574521013222 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 574521013223 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521013224 Walker A/P-loop; other site 574521013225 ATP binding site [chemical binding]; other site 574521013226 Q-loop/lid; other site 574521013227 ABC transporter signature motif; other site 574521013228 Walker B; other site 574521013229 D-loop; other site 574521013230 H-loop/switch region; other site 574521013231 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 574521013232 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 574521013233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521013234 dimer interface [polypeptide binding]; other site 574521013235 conserved gate region; other site 574521013236 ABC-ATPase subunit interface; other site 574521013237 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 574521013238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521013239 dimer interface [polypeptide binding]; other site 574521013240 conserved gate region; other site 574521013241 putative PBP binding loops; other site 574521013242 ABC-ATPase subunit interface; other site 574521013243 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 574521013244 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 574521013245 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 574521013246 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 574521013247 [4Fe-4S] binding site [ion binding]; other site 574521013248 molybdopterin cofactor binding site; other site 574521013249 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 574521013250 molybdopterin cofactor binding site; other site 574521013251 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 574521013252 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 574521013253 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 574521013254 multidrug resistance protein MdtN; Provisional; Region: PRK10476 574521013255 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 574521013256 HlyD family secretion protein; Region: HlyD_3; pfam13437 574521013257 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 574521013258 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 574521013259 D-allose kinase; Provisional; Region: PRK09698 574521013260 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 574521013261 nucleotide binding site [chemical binding]; other site 574521013262 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 574521013263 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 574521013264 substrate binding site [chemical binding]; other site 574521013265 hexamer interface [polypeptide binding]; other site 574521013266 metal binding site [ion binding]; metal-binding site 574521013267 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 574521013268 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 574521013269 TM-ABC transporter signature motif; other site 574521013270 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 574521013271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521013272 Walker A/P-loop; other site 574521013273 ATP binding site [chemical binding]; other site 574521013274 Q-loop/lid; other site 574521013275 ABC transporter signature motif; other site 574521013276 Walker B; other site 574521013277 D-loop; other site 574521013278 H-loop/switch region; other site 574521013279 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 574521013280 D-allose transporter subunit; Provisional; Region: PRK09701 574521013281 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 574521013282 ligand binding site [chemical binding]; other site 574521013283 dimerization interface [polypeptide binding]; other site 574521013284 zinc binding site [ion binding]; other site 574521013285 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 574521013286 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 574521013287 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 574521013288 putative active site [active] 574521013289 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 574521013290 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 574521013291 putative hydrolase; Provisional; Region: PRK02113 574521013292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521013293 Coenzyme A binding pocket [chemical binding]; other site 574521013294 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 574521013295 AAA domain; Region: AAA_18; pfam13238 574521013296 active site 574521013297 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 574521013298 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 574521013299 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 574521013300 active site 574521013301 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 574521013302 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 574521013303 Walker A/P-loop; other site 574521013304 ATP binding site [chemical binding]; other site 574521013305 Q-loop/lid; other site 574521013306 ABC transporter signature motif; other site 574521013307 Walker B; other site 574521013308 D-loop; other site 574521013309 H-loop/switch region; other site 574521013310 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 574521013311 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 574521013312 Walker A/P-loop; other site 574521013313 ATP binding site [chemical binding]; other site 574521013314 Q-loop/lid; other site 574521013315 ABC transporter signature motif; other site 574521013316 Walker B; other site 574521013317 D-loop; other site 574521013318 H-loop/switch region; other site 574521013319 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 574521013320 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 574521013321 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 574521013322 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 574521013323 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 574521013324 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 574521013325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521013326 DNA-binding site [nucleotide binding]; DNA binding site 574521013327 UTRA domain; Region: UTRA; pfam07702 574521013328 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 574521013329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 574521013330 dimer interface [polypeptide binding]; other site 574521013331 conserved gate region; other site 574521013332 putative PBP binding loops; other site 574521013333 ABC-ATPase subunit interface; other site 574521013334 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 574521013335 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 574521013336 substrate binding pocket [chemical binding]; other site 574521013337 membrane-bound complex binding site; other site 574521013338 hinge residues; other site 574521013339 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 574521013340 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 574521013341 Walker A/P-loop; other site 574521013342 ATP binding site [chemical binding]; other site 574521013343 Q-loop/lid; other site 574521013344 ABC transporter signature motif; other site 574521013345 Walker B; other site 574521013346 D-loop; other site 574521013347 H-loop/switch region; other site 574521013348 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 574521013349 dimer interface [polypeptide binding]; other site 574521013350 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 574521013351 hypothetical protein; Provisional; Region: PRK10220 574521013352 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 574521013353 PhnA protein; Region: PhnA; pfam03831 574521013354 hypothetical protein; Provisional; Region: PRK09866 574521013355 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 574521013356 G1 box; other site 574521013357 GTP/Mg2+ binding site [chemical binding]; other site 574521013358 G2 box; other site 574521013359 Switch I region; other site 574521013360 G3 box; other site 574521013361 Switch II region; other site 574521013362 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 574521013363 G2 box; other site 574521013364 Switch I region; other site 574521013365 G3 box; other site 574521013366 Switch II region; other site 574521013367 G4 box; other site 574521013368 G5 box; other site 574521013369 YjcZ-like protein; Region: YjcZ; pfam13990 574521013370 proline/glycine betaine transporter; Provisional; Region: PRK10642 574521013371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521013372 putative substrate translocation pore; other site 574521013373 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 574521013374 sensor protein BasS/PmrB; Provisional; Region: PRK10755 574521013375 HAMP domain; Region: HAMP; pfam00672 574521013376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521013377 dimer interface [polypeptide binding]; other site 574521013378 phosphorylation site [posttranslational modification] 574521013379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521013380 ATP binding site [chemical binding]; other site 574521013381 Mg2+ binding site [ion binding]; other site 574521013382 G-X-G motif; other site 574521013383 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 574521013384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521013385 active site 574521013386 phosphorylation site [posttranslational modification] 574521013387 intermolecular recognition site; other site 574521013388 dimerization interface [polypeptide binding]; other site 574521013389 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521013390 DNA binding site [nucleotide binding] 574521013391 putative metal dependent hydrolase; Provisional; Region: PRK11598 574521013392 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 574521013393 Sulfatase; Region: Sulfatase; pfam00884 574521013394 arginine:agmatin antiporter; Provisional; Region: PRK10644 574521013395 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 574521013396 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521013397 arginine decarboxylase; Provisional; Region: PRK15029 574521013398 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 574521013399 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 574521013400 homodimer interface [polypeptide binding]; other site 574521013401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521013402 catalytic residue [active] 574521013403 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 574521013404 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 574521013405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521013406 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521013407 alpha-galactosidase; Provisional; Region: PRK15076 574521013408 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 574521013409 NAD binding site [chemical binding]; other site 574521013410 sugar binding site [chemical binding]; other site 574521013411 divalent metal binding site [ion binding]; other site 574521013412 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 574521013413 dimer interface [polypeptide binding]; other site 574521013414 hypothetical protein; Provisional; Region: PRK09867 574521013415 fumarate hydratase; Provisional; Region: PRK15389 574521013416 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 574521013417 Fumarase C-terminus; Region: Fumerase_C; pfam05683 574521013418 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 574521013419 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 574521013420 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 574521013421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521013422 active site 574521013423 phosphorylation site [posttranslational modification] 574521013424 intermolecular recognition site; other site 574521013425 dimerization interface [polypeptide binding]; other site 574521013426 Transcriptional regulator; Region: CitT; pfam12431 574521013427 sensory histidine kinase DcuS; Provisional; Region: PRK11086 574521013428 PAS domain; Region: PAS; smart00091 574521013429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521013430 ATP binding site [chemical binding]; other site 574521013431 Mg2+ binding site [ion binding]; other site 574521013432 G-X-G motif; other site 574521013433 Uncharacterized conserved protein [Function unknown]; Region: COG3592 574521013434 Predicted acetyltransferase [General function prediction only]; Region: COG2388 574521013435 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 574521013436 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 574521013437 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 574521013438 dimer interface [polypeptide binding]; other site 574521013439 putative anticodon binding site; other site 574521013440 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 574521013441 motif 1; other site 574521013442 active site 574521013443 motif 2; other site 574521013444 motif 3; other site 574521013445 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 574521013446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521013447 putative substrate translocation pore; other site 574521013448 POT family; Region: PTR2; pfam00854 574521013449 lysine decarboxylase CadA; Provisional; Region: PRK15400 574521013450 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 574521013451 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 574521013452 homodimer interface [polypeptide binding]; other site 574521013453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 574521013454 catalytic residue [active] 574521013455 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 574521013456 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 574521013457 pseudogene, DNA-binding transcriptional activator, truncated by premature stop codon 574521013458 putative transcriptional regulator; Provisional; Region: PRK11640 574521013459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521013460 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 574521013461 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 574521013462 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 574521013463 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 574521013464 DsbD alpha interface [polypeptide binding]; other site 574521013465 catalytic residues [active] 574521013466 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 574521013467 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 574521013468 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 574521013469 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 574521013470 Aspartase; Region: Aspartase; cd01357 574521013471 active sites [active] 574521013472 tetramer interface [polypeptide binding]; other site 574521013473 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 574521013474 putative transporter; Provisional; Region: PRK11021 574521013475 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 574521013476 oligomerisation interface [polypeptide binding]; other site 574521013477 mobile loop; other site 574521013478 roof hairpin; other site 574521013479 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 574521013480 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 574521013481 ring oligomerisation interface [polypeptide binding]; other site 574521013482 ATP/Mg binding site [chemical binding]; other site 574521013483 stacking interactions; other site 574521013484 hinge regions; other site 574521013485 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 574521013486 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 574521013487 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521013488 FeS/SAM binding site; other site 574521013489 elongation factor P; Validated; Region: PRK00529 574521013490 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 574521013491 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 574521013492 RNA binding site [nucleotide binding]; other site 574521013493 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 574521013494 RNA binding site [nucleotide binding]; other site 574521013495 entericidin A; Provisional; Region: PRK09810 574521013496 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 574521013497 multidrug efflux system protein; Provisional; Region: PRK11431 574521013498 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 574521013499 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 574521013500 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 574521013501 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 574521013502 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 574521013503 Iron-sulfur protein interface; other site 574521013504 proximal quinone binding site [chemical binding]; other site 574521013505 C-subunit interface; other site 574521013506 distal quinone binding site; other site 574521013507 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 574521013508 D-subunit interface [polypeptide binding]; other site 574521013509 Iron-sulfur protein interface; other site 574521013510 proximal quinone binding site [chemical binding]; other site 574521013511 distal quinone binding site [chemical binding]; other site 574521013512 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 574521013513 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 574521013514 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 574521013515 L-aspartate oxidase; Provisional; Region: PRK06175 574521013516 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 574521013517 poxB regulator PoxA; Provisional; Region: PRK09350 574521013518 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 574521013519 motif 1; other site 574521013520 dimer interface [polypeptide binding]; other site 574521013521 active site 574521013522 motif 2; other site 574521013523 motif 3; other site 574521013524 inner membrane transporter YjeM; Provisional; Region: PRK15238 574521013525 putative mechanosensitive channel protein; Provisional; Region: PRK10929 574521013526 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 574521013527 DNA-binding site [nucleotide binding]; DNA binding site 574521013528 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 574521013529 Mechanosensitive ion channel; Region: MS_channel; pfam00924 574521013530 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 574521013531 GTPase RsgA; Reviewed; Region: PRK12288 574521013532 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 574521013533 RNA binding site [nucleotide binding]; other site 574521013534 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 574521013535 GTPase/Zn-binding domain interface [polypeptide binding]; other site 574521013536 GTP/Mg2+ binding site [chemical binding]; other site 574521013537 G4 box; other site 574521013538 G5 box; other site 574521013539 G1 box; other site 574521013540 Switch I region; other site 574521013541 G2 box; other site 574521013542 G3 box; other site 574521013543 Switch II region; other site 574521013544 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 574521013545 catalytic site [active] 574521013546 putative active site [active] 574521013547 putative substrate binding site [chemical binding]; other site 574521013548 dimer interface [polypeptide binding]; other site 574521013549 epoxyqueuosine reductase; Region: TIGR00276 574521013550 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 574521013551 putative carbohydrate kinase; Provisional; Region: PRK10565 574521013552 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 574521013553 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 574521013554 putative substrate binding site [chemical binding]; other site 574521013555 putative ATP binding site [chemical binding]; other site 574521013556 ADP-binding protein; Provisional; Region: PRK10646 574521013557 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 574521013558 AMIN domain; Region: AMIN; pfam11741 574521013559 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 574521013560 active site 574521013561 metal binding site [ion binding]; metal-binding site 574521013562 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 574521013563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521013564 ATP binding site [chemical binding]; other site 574521013565 Mg2+ binding site [ion binding]; other site 574521013566 G-X-G motif; other site 574521013567 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 574521013568 ATP binding site [chemical binding]; other site 574521013569 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 574521013570 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 574521013571 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 574521013572 bacterial Hfq-like; Region: Hfq; cd01716 574521013573 hexamer interface [polypeptide binding]; other site 574521013574 Sm1 motif; other site 574521013575 RNA binding site [nucleotide binding]; other site 574521013576 Sm2 motif; other site 574521013577 GTPase HflX; Provisional; Region: PRK11058 574521013578 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 574521013579 HflX GTPase family; Region: HflX; cd01878 574521013580 G1 box; other site 574521013581 GTP/Mg2+ binding site [chemical binding]; other site 574521013582 Switch I region; other site 574521013583 G2 box; other site 574521013584 G3 box; other site 574521013585 Switch II region; other site 574521013586 G4 box; other site 574521013587 G5 box; other site 574521013588 FtsH protease regulator HflK; Provisional; Region: PRK10930 574521013589 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 574521013590 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 574521013591 FtsH protease regulator HflC; Provisional; Region: PRK11029 574521013592 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 574521013593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 574521013594 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 574521013595 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 574521013596 GDP-binding site [chemical binding]; other site 574521013597 ACT binding site; other site 574521013598 IMP binding site; other site 574521013599 Predicted transcriptional regulator [Transcription]; Region: COG1959 574521013600 transcriptional repressor NsrR; Provisional; Region: PRK11014 574521013601 exoribonuclease R; Provisional; Region: PRK11642 574521013602 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 574521013603 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 574521013604 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 574521013605 RNB domain; Region: RNB; pfam00773 574521013606 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 574521013607 RNA binding site [nucleotide binding]; other site 574521013608 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 574521013609 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 574521013610 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 574521013611 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 574521013612 PspA/IM30 family; Region: PspA_IM30; pfam04012 574521013613 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 574521013614 Predicted membrane protein [Function unknown]; Region: COG3766 574521013615 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 574521013616 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 574521013617 Predicted integral membrane protein [Function unknown]; Region: COG5463 574521013618 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 574521013619 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 574521013620 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 574521013621 FAD binding site [chemical binding]; other site 574521013622 substrate binding site [chemical binding]; other site 574521013623 catalytic residues [active] 574521013624 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 574521013625 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 574521013626 esterase; Provisional; Region: PRK10566 574521013627 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 574521013628 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 574521013629 transcriptional repressor UlaR; Provisional; Region: PRK13509 574521013630 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 574521013631 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 574521013632 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 574521013633 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 574521013634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 574521013635 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 574521013636 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 574521013637 active site 574521013638 P-loop; other site 574521013639 phosphorylation site [posttranslational modification] 574521013640 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 574521013641 active site 574521013642 phosphorylation site [posttranslational modification] 574521013643 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 574521013644 active site 574521013645 dimer interface [polypeptide binding]; other site 574521013646 magnesium binding site [ion binding]; other site 574521013647 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 574521013648 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 574521013649 AP (apurinic/apyrimidinic) site pocket; other site 574521013650 DNA interaction; other site 574521013651 Metal-binding active site; metal-binding site 574521013652 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 574521013653 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 574521013654 intersubunit interface [polypeptide binding]; other site 574521013655 active site 574521013656 Zn2+ binding site [ion binding]; other site 574521013657 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 574521013658 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 574521013659 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 574521013660 dimer interface [polypeptide binding]; other site 574521013661 ssDNA binding site [nucleotide binding]; other site 574521013662 tetramer (dimer of dimers) interface [polypeptide binding]; other site 574521013663 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 574521013664 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 574521013665 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 574521013666 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 574521013667 Helix-turn-helix domain; Region: HTH_31; pfam13560 574521013668 pseudogene, conserved protein, truncated by frameshift mutation 574521013669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 574521013670 D-galactonate transporter; Region: 2A0114; TIGR00893 574521013671 putative substrate translocation pore; other site 574521013672 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 574521013673 L-aspartate oxidase; Provisional; Region: PRK06175 574521013674 L-aspartate oxidase; Provisional; Region: PRK06175 574521013675 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 574521013676 Coenzyme A transferase; Region: CoA_trans; smart00882 574521013677 Coenzyme A transferase; Region: CoA_trans; cl17247 574521013678 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 574521013679 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 574521013680 substrate binding site [chemical binding]; other site 574521013681 oxyanion hole (OAH) forming residues; other site 574521013682 trimer interface [polypeptide binding]; other site 574521013683 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 574521013684 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 574521013685 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 574521013686 putative NAD(P) binding site [chemical binding]; other site 574521013687 active site 574521013688 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 574521013689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521013690 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 574521013691 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 574521013692 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 574521013693 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 574521013694 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 574521013695 pseudogene, transposase of ISEc13, truncated by premature stop codon 574521013696 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 574521013697 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 574521013698 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 574521013699 Hemerythrin-like domain; Region: Hr-like; cd12108 574521013700 Fe binding site [ion binding]; other site 574521013701 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 574521013702 EamA-like transporter family; Region: EamA; pfam00892 574521013703 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 574521013704 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 574521013705 NADP binding site [chemical binding]; other site 574521013706 Predicted transcriptional regulators [Transcription]; Region: COG1733 574521013707 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 574521013708 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 574521013709 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 574521013710 active site 574521013711 metal binding site [ion binding]; metal-binding site 574521013712 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 574521013713 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 574521013714 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 574521013715 active site 574521013716 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 574521013717 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 574521013718 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 574521013719 Domain of unknown function DUF21; Region: DUF21; pfam01595 574521013720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 574521013721 Transporter associated domain; Region: CorC_HlyC; smart01091 574521013722 methionine sulfoxide reductase A; Provisional; Region: PRK00058 574521013723 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 574521013724 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 574521013725 Surface antigen; Region: Bac_surface_Ag; pfam01103 574521013726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 574521013727 Family of unknown function (DUF490); Region: DUF490; pfam04357 574521013728 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 574521013729 putative active site pocket [active] 574521013730 dimerization interface [polypeptide binding]; other site 574521013731 putative catalytic residue [active] 574521013732 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 574521013733 dimer interface [polypeptide binding]; other site 574521013734 substrate binding site [chemical binding]; other site 574521013735 metal binding sites [ion binding]; metal-binding site 574521013736 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 574521013737 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 574521013738 putative ligand binding site [chemical binding]; other site 574521013739 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 574521013740 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 574521013741 Walker A/P-loop; other site 574521013742 ATP binding site [chemical binding]; other site 574521013743 Q-loop/lid; other site 574521013744 ABC transporter signature motif; other site 574521013745 Walker B; other site 574521013746 D-loop; other site 574521013747 H-loop/switch region; other site 574521013748 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 574521013749 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 574521013750 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 574521013751 TM-ABC transporter signature motif; other site 574521013752 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 574521013753 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 574521013754 TM-ABC transporter signature motif; other site 574521013755 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 574521013756 AMP binding site [chemical binding]; other site 574521013757 metal binding site [ion binding]; metal-binding site 574521013758 active site 574521013759 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 574521013760 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 574521013761 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 574521013762 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 574521013763 hypothetical protein; Provisional; Region: PRK05255 574521013764 peptidase PmbA; Provisional; Region: PRK11040 574521013765 cytochrome b562; Provisional; Region: PRK15058 574521013766 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 574521013767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521013768 FeS/SAM binding site; other site 574521013769 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 574521013770 ATP cone domain; Region: ATP-cone; pfam03477 574521013771 Class III ribonucleotide reductase; Region: RNR_III; cd01675 574521013772 effector binding site; other site 574521013773 active site 574521013774 Zn binding site [ion binding]; other site 574521013775 glycine loop; other site 574521013776 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 574521013777 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 574521013778 Ca binding site [ion binding]; other site 574521013779 active site 574521013780 catalytic site [active] 574521013781 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 574521013782 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 574521013783 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 574521013784 active site turn [active] 574521013785 phosphorylation site [posttranslational modification] 574521013786 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 574521013787 trehalose repressor; Provisional; Region: treR; PRK09492 574521013788 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 574521013789 DNA binding site [nucleotide binding] 574521013790 domain linker motif; other site 574521013791 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 574521013792 dimerization interface [polypeptide binding]; other site 574521013793 ligand binding site [chemical binding]; other site 574521013794 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 574521013795 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 574521013796 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 574521013797 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 574521013798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521013799 motif II; other site 574521013800 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 574521013801 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 574521013802 homotrimer interaction site [polypeptide binding]; other site 574521013803 putative active site [active] 574521013804 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 574521013805 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 574521013806 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 574521013807 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 574521013808 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 574521013809 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 574521013810 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 574521013811 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 574521013812 homotrimer interaction site [polypeptide binding]; other site 574521013813 putative active site [active] 574521013814 oxidoreductase; Provisional; Region: PRK12742 574521013815 classical (c) SDRs; Region: SDR_c; cd05233 574521013816 NAD(P) binding site [chemical binding]; other site 574521013817 active site 574521013818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 574521013819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 574521013820 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 574521013821 pseudogene, conserved protein, fragments 574521013822 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 574521013823 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 574521013824 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 574521013825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 574521013826 RNase E inhibitor protein; Provisional; Region: PRK11191 574521013827 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 574521013828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521013829 Coenzyme A binding pocket [chemical binding]; other site 574521013830 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 574521013831 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 574521013832 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 574521013833 HIGH motif; other site 574521013834 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 574521013835 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 574521013836 active site 574521013837 KMSKS motif; other site 574521013838 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 574521013839 tRNA binding surface [nucleotide binding]; other site 574521013840 anticodon binding site; other site 574521013841 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 574521013842 DNA polymerase III subunit chi; Validated; Region: PRK05728 574521013843 multifunctional aminopeptidase A; Provisional; Region: PRK00913 574521013844 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 574521013845 interface (dimer of trimers) [polypeptide binding]; other site 574521013846 Substrate-binding/catalytic site; other site 574521013847 Zn-binding sites [ion binding]; other site 574521013848 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 574521013849 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 574521013850 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 574521013851 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 574521013852 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 574521013853 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 574521013854 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 574521013855 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 574521013856 putative NAD(P) binding site [chemical binding]; other site 574521013857 putative substrate binding site [chemical binding]; other site 574521013858 catalytic Zn binding site [ion binding]; other site 574521013859 structural Zn binding site [ion binding]; other site 574521013860 dimer interface [polypeptide binding]; other site 574521013861 prophage E2348_PP13 574521013862 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 574521013863 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 574521013864 catalytic residues [active] 574521013865 catalytic nucleophile [active] 574521013866 Presynaptic Site I dimer interface [polypeptide binding]; other site 574521013867 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 574521013868 Synaptic Flat tetramer interface [polypeptide binding]; other site 574521013869 Synaptic Site I dimer interface [polypeptide binding]; other site 574521013870 DNA binding site [nucleotide binding] 574521013871 DNA-binding interface [nucleotide binding]; DNA binding site 574521013872 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 574521013873 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 574521013874 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 574521013875 ATP binding site [chemical binding]; other site 574521013876 putative Mg++ binding site [ion binding]; other site 574521013877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 574521013878 nucleotide binding region [chemical binding]; other site 574521013879 ATP-binding site [chemical binding]; other site 574521013880 Homeodomain-like domain; Region: HTH_23; cl17451 574521013881 capsid protein; Region: PHA02004 574521013882 HNH endonuclease; Region: HNH_3; pfam13392 574521013883 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 574521013884 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 574521013885 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 574521013886 active site 574521013887 DNA binding site [nucleotide binding] 574521013888 Int/Topo IB signature motif; other site 574521013889 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 574521013890 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 574521013891 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 574521013892 ATP binding site [chemical binding]; other site 574521013893 putative Mg++ binding site [ion binding]; other site 574521013894 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 574521013895 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 574521013896 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 574521013897 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 574521013898 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 574521013899 HsdM N-terminal domain; Region: HsdM_N; pfam12161 574521013900 Methyltransferase domain; Region: Methyltransf_26; pfam13659 574521013901 S-adenosylmethionine binding site [chemical binding]; other site 574521013902 Methyltransferase domain; Region: Methyltransf_27; pfam13708 574521013903 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 574521013904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 574521013905 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 574521013906 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 574521013907 HNH endonuclease; Region: HNH_2; pfam13391 574521013908 pseudogene, C-ter part of restriction endonulease 574521013909 Domain of unknown function (DUF303); Region: DUF303; pfam03629 574521013910 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 574521013911 Kelch motif; Region: Kelch_1; pfam01344 574521013912 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 574521013913 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 574521013914 Int/Topo IB signature motif; other site 574521013915 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 574521013916 Int/Topo IB signature motif; other site 574521013917 Fimbrial protein; Region: Fimbrial; cl01416 574521013918 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 574521013919 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 574521013920 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 574521013921 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 574521013922 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 574521013923 PapC N-terminal domain; Region: PapC_N; pfam13954 574521013924 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 574521013925 PapC C-terminal domain; Region: PapC_C; pfam13953 574521013926 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 574521013927 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 574521013928 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 574521013929 mannosyl binding site [chemical binding]; other site 574521013930 Fimbrial protein; Region: Fimbrial; pfam00419 574521013931 mannonate dehydratase; Region: uxuA; TIGR00695 574521013932 mannonate dehydratase; Provisional; Region: PRK03906 574521013933 D-mannonate oxidoreductase; Provisional; Region: PRK15037 574521013934 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 574521013935 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 574521013936 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 574521013937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521013938 DNA-binding site [nucleotide binding]; DNA binding site 574521013939 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 574521013940 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 574521013941 pseudogene, C-ter part of fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein 574521013942 cell density-dependent motility repressor; Provisional; Region: PRK10082 574521013943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 574521013944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 574521013945 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 574521013946 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 574521013947 dimer interface [polypeptide binding]; other site 574521013948 active site 574521013949 hypothetical protein; Provisional; Region: PRK10519 574521013950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 574521013951 Nucleoside recognition; Region: Gate; pfam07670 574521013952 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 574521013953 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 574521013954 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 574521013955 SdiA-regulated; Region: SdiA-regulated; pfam06977 574521013956 SdiA-regulated; Region: SdiA-regulated; cd09971 574521013957 putative active site [active] 574521013958 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 574521013959 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 574521013960 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 574521013961 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 574521013962 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 574521013963 Predicted membrane protein [Function unknown]; Region: COG2733 574521013964 putative transposase; Provisional; Region: PRK09857 574521013965 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 574521013966 pseudogene, N-ter part of fused DNA-binding transcriptional regulator/ aminotransferase 574521013967 endoribonuclease SymE; Provisional; Region: PRK13605 574521013968 Nuclease-related domain; Region: NERD; pfam08378 574521013969 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 574521013970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 574521013971 ATP binding site [chemical binding]; other site 574521013972 putative Mg++ binding site [ion binding]; other site 574521013973 Family description; Region: UvrD_C_2; pfam13538 574521013974 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 574521013975 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 574521013976 P-loop, Walker A motif; other site 574521013977 Base recognition motif; other site 574521013978 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 574521013979 Uncharacterized small protein [Function unknown]; Region: COG2879 574521013980 carbon starvation protein A; Provisional; Region: PRK15015 574521013981 Carbon starvation protein CstA; Region: CstA; pfam02554 574521013982 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 574521013983 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 574521013984 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 574521013985 dimer interface [polypeptide binding]; other site 574521013986 ligand binding site [chemical binding]; other site 574521013987 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 574521013988 dimerization interface [polypeptide binding]; other site 574521013989 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 574521013990 dimer interface [polypeptide binding]; other site 574521013991 putative CheW interface [polypeptide binding]; other site 574521013992 DctM-like transporters; Region: DctM; pfam06808 574521013993 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 574521013994 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 574521013995 pseudogene, C4-dicarboxylate transport system, periplasmic component, truncated by frameshift mutation 574521013996 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 574521013997 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 574521013998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 574521013999 DNA-binding site [nucleotide binding]; DNA binding site 574521014000 Transcriptional regulators [Transcription]; Region: GntR; COG1802 574521014001 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 574521014002 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 574521014003 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 574521014004 putative NAD(P) binding site [chemical binding]; other site 574521014005 catalytic Zn binding site [ion binding]; other site 574521014006 structural Zn binding site [ion binding]; other site 574521014007 phosphoglycerol transferase I; Provisional; Region: PRK03776 574521014008 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 574521014009 hypothetical protein; Provisional; Region: PRK11667 574521014010 DNA replication protein DnaC; Validated; Region: PRK07952 574521014011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 574521014012 Walker A motif; other site 574521014013 ATP binding site [chemical binding]; other site 574521014014 Walker B motif; other site 574521014015 primosomal protein DnaI; Provisional; Region: PRK02854 574521014016 hypothetical protein; Provisional; Region: PRK09917 574521014017 Uncharacterized conserved protein [Function unknown]; Region: COG2966 574521014018 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 574521014019 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 574521014020 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521014021 DNA binding residues [nucleotide binding] 574521014022 dimerization interface [polypeptide binding]; other site 574521014023 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 574521014024 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 574521014025 DNA binding residues [nucleotide binding] 574521014026 dimerization interface [polypeptide binding]; other site 574521014027 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 574521014028 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 574521014029 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 574521014030 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 574521014031 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 574521014032 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 574521014033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 574521014034 S-adenosylmethionine binding site [chemical binding]; other site 574521014035 DNA polymerase III subunit psi; Validated; Region: PRK06856 574521014036 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 574521014037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 574521014038 Coenzyme A binding pocket [chemical binding]; other site 574521014039 dUMP phosphatase; Provisional; Region: PRK09449 574521014040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521014041 motif II; other site 574521014042 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 574521014043 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 574521014044 G1 box; other site 574521014045 putative GEF interaction site [polypeptide binding]; other site 574521014046 GTP/Mg2+ binding site [chemical binding]; other site 574521014047 Switch I region; other site 574521014048 G2 box; other site 574521014049 G3 box; other site 574521014050 Switch II region; other site 574521014051 G4 box; other site 574521014052 G5 box; other site 574521014053 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 574521014054 periplasmic protein; Provisional; Region: PRK10568 574521014055 BON domain; Region: BON; pfam04972 574521014056 BON domain; Region: BON; pfam04972 574521014057 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 574521014058 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 574521014059 active site 574521014060 nucleophile elbow; other site 574521014061 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 574521014062 active site 574521014063 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 574521014064 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 574521014065 FeS/SAM binding site; other site 574521014066 hypothetical protein; Provisional; Region: PRK10977 574521014067 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 574521014068 intersubunit interface [polypeptide binding]; other site 574521014069 active site 574521014070 catalytic residue [active] 574521014071 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 574521014072 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 574521014073 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 574521014074 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 574521014075 phosphopentomutase; Provisional; Region: PRK05362 574521014076 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 574521014077 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 574521014078 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 574521014079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521014080 non-specific DNA binding site [nucleotide binding]; other site 574521014081 salt bridge; other site 574521014082 sequence-specific DNA binding site [nucleotide binding]; other site 574521014083 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 574521014084 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 574521014085 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 574521014086 hypothetical protein; Provisional; Region: PRK11246 574521014087 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 574521014088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 574521014089 motif II; other site 574521014090 DNA repair protein RadA; Region: sms; TIGR00416 574521014091 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 574521014092 Walker A motif/ATP binding site; other site 574521014093 ATP binding site [chemical binding]; other site 574521014094 Walker B motif; other site 574521014095 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 574521014096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521014097 non-specific DNA binding site [nucleotide binding]; other site 574521014098 salt bridge; other site 574521014099 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 574521014100 sequence-specific DNA binding site [nucleotide binding]; other site 574521014101 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 574521014102 active site 574521014103 (T/H)XGH motif; other site 574521014104 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 574521014105 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 574521014106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 574521014107 non-specific DNA binding site [nucleotide binding]; other site 574521014108 salt bridge; other site 574521014109 sequence-specific DNA binding site [nucleotide binding]; other site 574521014110 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 574521014111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521014112 Walker A/P-loop; other site 574521014113 ATP binding site [chemical binding]; other site 574521014114 Q-loop/lid; other site 574521014115 ABC transporter signature motif; other site 574521014116 Walker B; other site 574521014117 D-loop; other site 574521014118 H-loop/switch region; other site 574521014119 ABC transporter; Region: ABC_tran_2; pfam12848 574521014120 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 574521014121 lytic murein transglycosylase; Provisional; Region: PRK11619 574521014122 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 574521014123 N-acetyl-D-glucosamine binding site [chemical binding]; other site 574521014124 catalytic residue [active] 574521014125 Trp operon repressor; Provisional; Region: PRK01381 574521014126 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 574521014127 pseudogene, phosphoglyceromutase 2, co-factor independent, truncated by premature stop codon 574521014128 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 574521014129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521014130 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 574521014131 hypothetical protein; Provisional; Region: PRK10756 574521014132 CreA protein; Region: CreA; pfam05981 574521014133 DNA-binding response regulator CreB; Provisional; Region: PRK11083 574521014134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521014135 active site 574521014136 phosphorylation site [posttranslational modification] 574521014137 intermolecular recognition site; other site 574521014138 dimerization interface [polypeptide binding]; other site 574521014139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521014140 DNA binding site [nucleotide binding] 574521014141 sensory histidine kinase CreC; Provisional; Region: PRK11100 574521014142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 574521014143 dimerization interface [polypeptide binding]; other site 574521014144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 574521014145 dimer interface [polypeptide binding]; other site 574521014146 phosphorylation site [posttranslational modification] 574521014147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 574521014148 ATP binding site [chemical binding]; other site 574521014149 Mg2+ binding site [ion binding]; other site 574521014150 G-X-G motif; other site 574521014151 pseudogene, inner membrane protein, truncated by frameshift mutation 574521014152 two-component response regulator; Provisional; Region: PRK11173 574521014153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 574521014154 active site 574521014155 phosphorylation site [posttranslational modification] 574521014156 intermolecular recognition site; other site 574521014157 dimerization interface [polypeptide binding]; other site 574521014158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 574521014159 DNA binding site [nucleotide binding] 574521014160 putative RNA methyltransferase; Provisional; Region: PRK10433 574521014161 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 574521014162 dihydropteroate synthase; Region: DHPS; TIGR01496 574521014163 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 574521014164 substrate binding pocket [chemical binding]; other site 574521014165 dimer interface [polypeptide binding]; other site 574521014166 inhibitor binding site; inhibition site 574521014167 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 574521014168 Phosphotransferase enzyme family; Region: APH; pfam01636 574521014169 active site 574521014170 ATP binding site [chemical binding]; other site 574521014171 antibiotic binding site [chemical binding]; other site 574521014172 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 574521014173 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 574521014174 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 574521014175 Initiator Replication protein; Region: Rep_3; cl03080 574521014176 pseudogene, putative recombinase, truncated by premature stop codon and 30 aa deleted 574521014177 Bundlin; Region: Bundlin; pfam05307 574521014178 PilS N terminal; Region: PilS; pfam08805 574521014179 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 574521014180 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 574521014181 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 574521014182 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 574521014183 Walker A motif; other site 574521014184 ATP binding site [chemical binding]; other site 574521014185 Walker B motif; other site 574521014186 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 574521014187 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 574521014188 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 574521014189 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 574521014190 Walker A motif; other site 574521014191 ATP binding site [chemical binding]; other site 574521014192 Walker B motif; other site 574521014193 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 574521014194 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 574521014195 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 574521014196 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 574521014197 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 574521014198 N-acetyl-D-glucosamine binding site [chemical binding]; other site 574521014199 catalytic residue [active] 574521014200 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 574521014201 pseudogene, transposase of IS481 family, fragmented by multiple mutations 574521014202 putative transposase OrfB; Reviewed; Region: PHA02517 574521014203 HTH-like domain; Region: HTH_21; pfam13276 574521014204 Integrase core domain; Region: rve; pfam00665 574521014205 Integrase core domain; Region: rve_2; pfam13333 574521014206 Transposase; Region: HTH_Tnp_1; cl17663 574521014207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 574521014208 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 574521014209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 574521014210 PerB protein; Region: PerB; pfam06590 574521014211 PerC transcriptional activator; Region: PerC; pfam06069 574521014212 pseudogene, transposase of IS1414, fragmented by multiple mutations 574521014213 pseudogene, transposase of ISfl1, fragmented by multiple mutations 574521014214 pseudogene, transposase of IS91 family, fragmented by multiple mutations 574521014215 pseudogene, putative acetyltransferase, N-ter part missing 574521014216 pseudogene, toxin B, truncated by multiple mutations 574521014217 pseudogene, truncated transposase Orf2 of IS3 family 574521014218 pseudogene, transposase Orf2 of IS21, fargmented by deletion 574521014219 pseudogene, C-ter part of transposase Orf1 of IS21 574521014220 pseudogene, transposase Orf1 of IS100, truncated by frameshift mutation 574521014221 pseudogene, transposase Orf2 of IS100, truncated by premature stop codon 574521014222 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 574521014223 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 574521014224 replication protein; Provisional; Region: PRK13750 574521014225 replication protein; Provisional; Region: PRK13702 574521014226 Hok/gef family; Region: HOK_GEF; pfam01848 574521014227 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521014228 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 574521014229 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 574521014230 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 574521014231 putative RNA binding sites [nucleotide binding]; other site 574521014232 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 574521014233 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 574521014234 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 574521014235 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 574521014236 AAA domain; Region: AAA_30; pfam13604 574521014237 DNA helicase TraI; Region: TraI; pfam07057 574521014238 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 574521014239 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 574521014240 oligomeric interface; other site 574521014241 putative active site [active] 574521014242 homodimer interface [polypeptide binding]; other site 574521014243 conjugal transfer protein TraD; Provisional; Region: PRK13700 574521014244 F sex factor protein N terminal; Region: TraD_N; pfam12615 574521014245 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 574521014246 multimer interface [polypeptide binding]; other site 574521014247 Walker A motif; other site 574521014248 ATP binding site [chemical binding]; other site 574521014249 Walker B motif; other site 574521014250 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 574521014251 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 574521014252 conjugal transfer entry exclusion protein TraS; Provisional; Region: PRK13741 574521014253 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 574521014254 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 574521014255 conjugal transfer protein TrbF; Provisional; Region: PRK13743 574521014256 conjugal transfer protein TrbJ; Provisional; Region: PRK13711 574521014257 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 574521014258 catalytic residues [active] 574521014259 conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727 574521014260 conjugal transfer protein TrbA; Provisional; Region: PRK13712 574521014261 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 574521014262 F plasmid transfer operon protein; Region: TraF; pfam13728 574521014263 conjugal transfer protein TrbE; Provisional; Region: PRK13718 574521014264 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 574521014265 conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730 574521014266 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 574521014267 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 574521014268 conjugal transfer protein TrbI; Provisional; Region: PRK13717 574521014269 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 574521014270 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 574521014271 conjugal transfer protein TraR; Provisional; Region: PRK13715 574521014272 conjugal transfer protein TraV; Provisional; Region: PRK13733 574521014273 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 574521014274 conjugal transfer protein TrbG; Provisional; Region: PRK13744 574521014275 conjugal transfer protein TrbD; Provisional; Region: PRK13724 574521014276 conjugal transfer protein TraP; Provisional; Region: PRK13739 574521014277 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 574521014278 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 574521014279 conjugal transfer protein TraK; Provisional; Region: PRK13736 574521014280 TraK protein; Region: TraK; pfam06586 574521014281 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 574521014282 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 574521014283 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 574521014284 conjugal transfer protein TraY; Provisional; Region: PRK13740 574521014285 PAS fold; Region: PAS; pfam00989 574521014286 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 574521014287 conjugal transfer protein TraM; Provisional; Region: PRK13713 574521014288 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 574521014289 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 574521014290 N-acetyl-D-glucosamine binding site [chemical binding]; other site 574521014291 catalytic residue [active] 574521014292 Domain of unknown function (DUF932); Region: DUF932; pfam06067 574521014293 pseudogene, conserved predicted protein, truncated by premature stop codon 574521014294 pseudogene, C-ter part of conserved predicted protein, disrupted by ISEc13 574521014295 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 574521014296 pseudogene, N-ter part of conserved predicted protein, disrupted by ISEc13 574521014297 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 574521014298 Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077 574521014299 Antirestriction protein; Region: Antirestrict; pfam03230 574521014300 pseudogene, N-ter part of predicted transposase 574521014301 pseudogene, N-ter part of transposase Orf1 of IS911 574521014302 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 574521014303 DNA-binding interface [nucleotide binding]; DNA binding site 574521014304 Helix-turn-helix domain; Region: HTH_38; pfam13936 574521014305 Integrase core domain; Region: rve; pfam00665 574521014306 pseudogene, N-ter part of transposase Orf2 of IS911 574521014307 Transposase; Region: DEDD_Tnp_IS110; pfam01548 574521014308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 574521014309 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 574521014310 pseudogene, C-ter part of transposase Orf2 of IS911 574521014311 pseudogene, C-ter part of tansposase Orf2 of ISH1 574521014312 pseudogene, glutamate decarboxylase, truncated by frameshift mutation 574521014313 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 574521014314 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 574521014315 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 574521014316 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 574521014317 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 574521014318 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 574521014319 pseudogene, fragmented DNA polymerase IV 574521014320 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 574521014321 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 574521014322 Mg binding site [ion binding]; other site 574521014323 nucleotide binding site [chemical binding]; other site 574521014324 putative protofilament interface [polypeptide binding]; other site 574521014325 ParA-like protein; Provisional; Region: PHA02518 574521014326 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 574521014327 P-loop; other site 574521014328 Magnesium ion binding site [ion binding]; other site 574521014329 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 574521014330 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 574521014331 Phage integrase family; Region: Phage_integrase; pfam00589 574521014332 active site 574521014333 DNA binding site [nucleotide binding] 574521014334 Int/Topo IB signature motif; other site 574521014335 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 574521014336 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 574521014337 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 574521014338 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 574521014339 active site 574521014340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 574521014341 Walker A/P-loop; other site 574521014342 ATP binding site [chemical binding]; other site 574521014343 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 574521014344 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 574521014345 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 574521014346 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681