-- dump date 20140619_085817 -- class Genbank::CDS -- table cds_note -- id note NP_285693.1 involved in threonine biosynthesis; controls the expression of the thrLABC operon NP_285694.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways NP_285695.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate NP_285696.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine NP_285700.1 Maintains the balance of metabolites in the pentose-phosphate pathway NP_285701.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis NP_285706.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria NP_285707.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion NP_285709.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH NP_285710.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC NP_285711.1 No significant matches NP_285712.1 No significant matches NP_285716.1 No significant matches NP_285717.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase NP_285719.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities NP_285720.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme NP_285721.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis NP_285723.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway NP_285724.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides NP_285725.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis NP_285726.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers NP_285727.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity NP_285728.1 No significant matches NP_285729.2 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons NP_285730.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities NP_285731.2 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA NP_285733.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine NP_285734.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA NP_285735.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism NP_285736.2 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase NP_285737.1 involved in electron transfer during carnitine metabolism NP_285738.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction NP_285741.1 Required for full activity of KefC, a potassium-proton antiporter NP_285742.1 transport system that facilitates potassium-efflux NP_285743.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate NP_285746.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP NP_285747.1 protein associated with Co2+ and Mg2+ efflux NP_285748.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin NP_285749.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) NP_285750.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB NP_285751.1 determines N-hexane tolerance and is involved in outer membrane permeability NP_285752.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system NP_285754.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs NP_285755.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA NP_285756.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C NP_285757.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source NP_285758.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism NP_285759.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate NP_285760.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose NP_285762.1 with TbpA and ThiP is part of the thiamine and TPP transport system NP_285763.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine NP_285764.1 part of the thiamine and TPP transport system tbpA-thiPQ NP_285766.1 activates sgrS under glucose-phosphate stress conditions NP_285767.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D NP_285768.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate NP_285769.2 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis NP_285770.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis NP_285771.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis NP_285772.1 activator for leuABCD operon; member of LysR family of transcriptional activators NP_285773.2 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive NP_285774.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit NP_285776.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism NP_285777.1 MraZ; UPF0040; crystal structure shows similarity to AbrB NP_285779.1 membrane bound cell division protein at septum containing leucine zipper motif NP_285781.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate NP_285783.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan NP_285784.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation NP_285785.1 integral membrane protein involved in stabilizing FstZ ring during cell division NP_285786.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis NP_285787.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis NP_285788.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli NP_285789.1 involved in septum formation NP_285790.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane NP_285791.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function NP_285792.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis NP_285793.2 secM translational pause allows for the initiation of secA translation NP_285794.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins NP_285799.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis NP_285800.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate NP_285805.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide NP_285807.1 involved in regulation of beta-lactamase; signaling protein NP_285809.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex NP_285810.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC NP_285811.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains NP_285812.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide NP_285814.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate NP_285816.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine NP_285817.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine NP_285819.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification NP_285821.2 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively NP_285822.1 catalyzes the interconversion of bicarbonate and carbon dioxide NP_285827.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) NP_285829.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine NP_285830.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate NP_285835.2 similar to the fimbrial usher protein PapC NP_285838.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP NP_285839.2 Polymerase that creates the 3' poly(A) tail found in some mRNA's NP_285840.2 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu NP_285842.1 Regulatory factor involved in maltose metabolism NP_285844.1 similar in sequence to the ATP-dependent RNA helicase HrpA NP_285845.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell NP_285846.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein NP_285847.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter NP_285848.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores NP_285849.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome NP_285850.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway NP_285851.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation NP_285852.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors NP_285854.1 solute binding component of the vitamin B12 transport system BtuCDF NP_285855.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine NP_285856.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate NP_285857.1 protease Do; required at high temperature; degrades damaged proteins NP_285858.2 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization NP_285860.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway NP_285861.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein NP_285862.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn NP_285863.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit NP_285864.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu NP_285865.1 Catalyzes the phosphorylation of UMP to UDP NP_285866.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs NP_285867.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate NP_285868.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate NP_285869.2 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate NP_285870.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response NP_285871.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins NP_285873.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis NP_285874.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP NP_285875.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis NP_285876.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM NP_285877.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids NP_285878.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase NP_285879.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein NP_285882.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase NP_285883.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination NP_285888.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) NP_285892.1 part of the MetNIQ methionine uptake system NP_285893.1 part of the metNIQ transport system for methionine NP_285894.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate NP_285895.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid NP_285899.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall NP_285900.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione NP_285902.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids NP_285903.1 3'-5' exonuclease of DNA polymerase III NP_285905.1 No significant matches NP_285906.1 No significant matches NP_285907.1 No significant matches NP_285908.1 No significant matches NP_285910.1 No significant matches NP_285912.1 No significant matches NP_285913.1 No significant matches NP_285914.1 No significant matches NP_285916.1 No significant matches NP_285918.1 No significant matches NP_285919.1 No significant matches NP_285920.1 No significant matches NP_285921.1 No significant matches NP_285922.1 No significant matches NP_285924.1 No significant matches NP_285926.1 No significant matches NP_285933.1 No significant matches NP_285937.1 inactivates vertebrate C-type lysozyme NP_285938.2 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA NP_285939.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate NP_285948.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function NP_285950.1 YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function NP_285953.1 similar to release factor 1 and 2 NP_285955.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively NP_285956.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation NP_285957.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS NP_285959.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis NP_285960.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway NP_285967.1 No significant matches NP_285977.1 No significant matches NP_285978.1 No significant matches NP_285979.1 No significant matches NP_285980.1 No significant matches NP_285981.1 No significant matches NP_285982.1 No significant matches NP_285986.1 No significant matches NP_285995.1 No significant matches NP_285996.1 No significant matches NP_286012.1 No significant matches NP_286014.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_286021.1 No significant matches NP_286022.1 No significant matches NP_286030.2 Involved in disulfide oxidoreductase activity and electron transport NP_286039.1 No significant matches NP_286040.1 No significant matches NP_286041.1 No significant matches NP_286044.1 No significant matches NP_286045.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine NP_286046.1 catalyzes the formation of betaine from betaine aldehyde NP_286047.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes NP_286048.1 proton-motive-force-driven choline transporter NP_286058.1 forms a homodimer; may be used to synthesize carbomyl phosphate from ATP and carbamate NP_286059.1 metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain NP_286072.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate NP_286073.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity NP_286074.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C NP_286075.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent NP_286076.1 No significant matches NP_286078.1 Catalyzes the deamination of cytosine to uracil and ammonia NP_286079.1 controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source NP_286081.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide NP_286082.1 MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential NP_286083.1 transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown NP_286084.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments NP_286085.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon NP_286086.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer NP_286089.1 activator of 3-phenylpropionic acid catabolism NP_286090.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate NP_286091.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase NP_286093.1 catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid NP_286094.1 catalyzes the formation of acetyl-CoA from acetalaldehyde NP_286095.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate NP_286100.1 formaldehyde-induced negative regulator of the frmRAB operon NP_286101.2 Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import NP_286107.1 with TauB and TauC is responsible for taurine uptake. NP_286108.1 Part of the ABC transporter complex tauABC involved in taurine import NP_286110.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers NP_286111.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate NP_286114.1 this protein has no known enzymatic function NP_286115.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope NP_286119.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli NP_286123.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis NP_286124.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate NP_286126.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis NP_286131.1 No significant matches NP_286132.1 Required for efficient pilin antigenic variation NP_286133.2 catalyzes phosphorylation of fructose; cytosolic enzyme NP_286134.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers NP_286135.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity NP_286136.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity NP_286137.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB NP_286138.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB NP_286140.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation NP_286143.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP NP_286144.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step NP_286145.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) NP_286146.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex NP_286147.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane NP_286148.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF NP_286155.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil NP_286156.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not NP_286157.1 Regulates rRNA biosynthesis by transcriptional antitermination NP_286158.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP NP_286159.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate NP_286162.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate NP_286164.1 catalyzes the bidirectional exonucleolytic cleavage of DNA NP_286165.1 Required for the synthesis of the thiazole moiety NP_286167.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis NP_286168.2 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription NP_286170.1 converts protoheme IX and farnesyl diphosphate to heme O NP_286175.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein NP_286177.2 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress NP_286178.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer NP_286179.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates NP_286180.1 binds and unfolds substrates as part of the ClpXP protease NP_286182.1 histone-like DNA-binding protein NP_286186.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His NP_286192.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia. NP_286201.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins NP_286205.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine NP_286206.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS NP_286208.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks NP_286210.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis NP_286211.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA NP_286213.1 involved in a recombinational process of DNA repair, independent of the recBC complex NP_286214.1 molecular chaperone NP_286215.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP NP_286216.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic NP_286219.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein NP_286221.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides NP_286226.1 catalyzes the formation of glutamate from glutamine NP_286234.1 No significant matches NP_286236.1 No significant matches NP_286249.1 No significant matches NP_286251.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA NP_286252.1 activator of the allDC-ylbA operon involved in allantoin utilization NP_286253.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate NP_286254.1 regulates operons involved in the utilization of allantoin NP_286255.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate NP_286260.1 Plays a crucial role on both purine and pyrimidine metabolism NP_286265.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide NP_286267.1 multicopy suppressor of dominant negative ftsH mutations NP_286270.1 forms a homodimer; may be used to synthesize carbomyl phosphate from ATP and carbamate NP_286271.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway NP_286272.1 Catalyzes a step in the de novo purine nucleotide biosynthetic pathway NP_286273.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine NP_286275.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA NP_286278.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate NP_286284.1 activates the production of the major fimbrae protein FimA NP_286290.1 No significant matches NP_286293.1 No significant matches NP_286296.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system NP_286297.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver NP_286299.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver NP_286303.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive NP_286306.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity NP_286310.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space NP_286312.1 No significant matches NP_286313.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin NP_286314.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake NP_286315.1 with FepBDE is involved in the transport of ferric enterobactin NP_286316.1 with FepBCD is involved in the transport of ferric enterobactin NP_286317.1 with FepBCG is involved in the transport of ferric enterobactin NP_286318.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters NP_286319.1 with FepCDG is involved in the transport of ferric enterobactin NP_286320.1 synthesizes isochorismate acid from chorismate NP_286321.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate NP_286323.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin NP_286326.1 member of the iron-containing alcohol dehydrogenase; unknown function NP_286327.1 catalyzes the transfer of an amino moiety NP_286331.2 Involved in disulfide bond formation NP_286332.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate NP_286337.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation NP_286340.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA NP_286341.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate NP_286344.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate NP_286347.1 regulates the expression of citAB in citrate fermentation NP_286348.1 responsible for the transport of C4-dicarboxylates during anaerobic growth NP_286349.1 catalyzes the transfer of palmitate to lipid A NP_286350.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator NP_286351.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling NP_286353.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes NP_286354.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group NP_286356.2 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein NP_286358.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors NP_286362.1 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA NP_286365.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria NP_286366.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA NP_286367.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane NP_286368.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase NP_286377.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific NP_286382.1 Transfers the fatty acyl group on membrane lipoproteins NP_286386.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) NP_286387.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q NP_286388.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP NP_286391.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate NP_286392.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate NP_286393.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel NP_286394.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_286398.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer NP_286399.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group NP_286402.1 negative modulator of the initiation of chromosome replication NP_286403.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate NP_286404.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system NP_286406.1 No significant matches NP_286407.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport NP_286408.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein NP_286409.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex NP_286410.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions NP_286411.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions NP_286418.1 No significant matches NP_286423.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent NP_286429.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity NP_286436.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH NP_286439.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol NP_286440.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase NP_286442.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide NP_286443.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA NP_286444.1 catalyzes the interconversion of succinyl-CoA and succinate NP_286445.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle NP_286446.1 No significant matches NP_286448.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide NP_286451.1 No significant matches NP_286456.1 converts methylaspartate to L-glutamate NP_286457.1 No significant matches NP_286458.1 No significant matches NP_286459.1 No significant matches NP_286464.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components NP_286465.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins NP_286466.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins NP_286467.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins NP_286468.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA NP_286470.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity NP_286471.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate NP_286473.1 involved in zinc efflux across the cytoplasmic membrane NP_286475.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive NP_286476.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate NP_286477.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose NP_286478.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism NP_286479.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P NP_286481.2 contains 2 ATP-binding cassettes; involved in the transport of molybdenum NP_286482.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons NP_286484.1 with ModCB is involved in the high-affinity transport of molybdate NP_286485.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE NP_286486.1 Part of the ABC transporter complex modABC involved in molybdenum import NP_286487.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily NP_286488.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate NP_286493.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase NP_286496.1 No significant matches NP_286506.1 No significant matches NP_286510.1 No significant matches NP_286511.1 No significant matches NP_286514.1 No significant matches NP_286516.1 No significant matches NP_286517.1 No significant matches NP_286533.1 No significant matches NP_286534.1 No significant matches NP_286535.1 No significant matches NP_286536.1 YbhB; similar to rat and human kinase inhibitory proteins NP_286537.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate NP_286539.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine NP_286540.1 methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth NP_286541.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium NP_286542.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion NP_286544.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z NP_286546.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis NP_286547.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin NP_286548.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin NP_286560.1 this helicase is not essential cell growth NP_286561.1 No significant matches NP_286563.1 helicase involved in DNA repair and perhaps also replication NP_286569.1 Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein NP_286573.1 similar to ABC transporter ATP-binding proteins NP_286574.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine NP_286575.1 similar to periplasmic-binding component of ABC transporters NP_286576.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage NP_286578.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains NP_286581.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present NP_286589.2 similar to transaldolase from Escherichia coli; many organisms have multiple copies NP_286590.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase NP_286591.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum NP_286593.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains NP_286601.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit NP_286602.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing NP_286605.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains NP_286615.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase NP_286616.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function NP_286617.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds NP_286618.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 NP_286621.1 part of the PotFGHI ATP-dependent putrescine transporter NP_286625.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA NP_286626.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr NP_286630.1 with ArtPQJI acts to transport arginine across the inner membrane NP_286631.1 with ArtPMJI transports arginine across the inner membrane NP_286633.1 With ArtMQJI transports arginine across the inner membrane NP_286634.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS NP_286635.1 No significant matches NP_286636.1 No significant matches NP_286637.1 No significant matches NP_286642.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine NP_286643.1 catalyzes the formation of acetate from pyruvate NP_286645.2 catalyzes the reduction of hydroxylamine to ammonia and water NP_286647.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure NP_286650.2 confers macrolide resistance via active drug efflux NP_286651.1 with MacA is involved in the export of macrolide NP_286652.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible NP_286653.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA NP_286654.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates NP_286656.1 No significant matches NP_286663.1 No significant matches NP_286665.1 No significant matches NP_286671.1 No significant matches NP_286672.1 No significant matches NP_286673.1 No significant matches NP_286676.1 No significant matches NP_286678.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter NP_286679.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active NP_286680.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits NP_286681.1 involved in the assembly of the urease metallocenter; possible nickel donor NP_286687.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_286688.1 No significant matches NP_286689.1 No significant matches NP_286690.1 No significant matches NP_286691.1 No significant matches NP_286692.1 No significant matches NP_286700.1 No significant matches NP_286713.1 IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor NP_286715.1 No significant matches NP_286717.1 No significant matches NP_286719.1 No significant matches NP_286720.1 No significant matches NP_286721.1 No significant matches NP_286722.1 No significant matches NP_286723.1 No significant matches NP_286724.1 No significant matches NP_286728.1 No significant matches NP_286729.1 No significant matches NP_286730.1 No significant matches NP_286731.1 No significant matches NP_286732.1 No significant matches NP_286736.1 No significant matches NP_286740.1 No significant matches NP_286741.1 No significant matches NP_286744.1 No significant matches NP_286754.1 No significant matches NP_286761.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 NP_286762.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys NP_286763.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c NP_286764.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c NP_286765.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding NP_286766.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system NP_286767.1 DNA-binding membrane protein required for chromosome resolution and partitioning NP_286768.1 participates with LolB in the incorporation of lipoprotein into the outer membrane NP_286770.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_286777.1 activates pyruvate formate-lyase 1 under anaerobic conditions NP_286782.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine NP_286783.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis NP_286785.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP NP_286786.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins NP_286787.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control NP_286789.1 involved in the transport of lipid A across the inner membrane NP_286790.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate NP_286793.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS NP_286796.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA NP_286797.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division NP_286798.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division NP_286799.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects NP_286803.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate NP_286804.1 outer membrane porin F; 1a; Ia; b NP_286805.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_286806.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate NP_286808.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease NP_286809.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease NP_286810.1 catalyzes the release of sulfite from alkanesulfonates NP_286811.2 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease NP_286820.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors NP_286823.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA NP_286824.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth NP_286829.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP NP_286832.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d NP_286837.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand NP_286838.2 catalyzes the formation of methylglyoxal from glycerone phosphate NP_286843.1 catalyzes the hydrolysis of acylphosphate NP_286844.2 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs NP_286850.1 No significant matches NP_286851.1 No significant matches NP_286854.1 No significant matches NP_286856.1 No significant matches NP_286858.1 No significant matches NP_286859.1 No significant matches NP_286860.1 acts to load the DnaB helicase onto the intiation site durning DNA replication NP_286862.1 No significant matches NP_286869.1 No significant matches NP_286870.1 No significant matches NP_286878.1 No significant matches NP_286879.1 No significant matches NP_286883.1 No significant matches NP_286884.1 No significant matches NP_286886.1 No significant matches NP_286887.1 No significant matches NP_286888.1 No significant matches NP_286907.1 No significant matches NP_286910.1 involved in hydrogen cycling during fermentative growth NP_286912.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1) NP_286913.1 involved in processing hydrogenases HyaA and HyaB NP_286919.2 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk NP_286929.2 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide NP_286930.1 periplasmic sensory protein associated with the TorRS two-component regulatory system NP_286931.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes NP_286934.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor NP_286935.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA NP_286936.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock NP_286941.1 stationary phase that binds TrpR repressor NP_286945.1 No significant matches NP_286948.1 No significant matches NP_286982.1 No significant matches NP_287019.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein NP_287021.1 No significant matches NP_287022.1 No significant matches NP_287023.1 No significant matches NP_287028.1 in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export NP_287029.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein NP_287030.1 in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export NP_287031.1 outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia NP_287036.1 No significant matches NP_287043.1 No significant matches NP_287044.1 No significant matches NP_287045.1 No significant matches NP_287055.1 No significant matches NP_287057.1 No significant matches NP_287059.1 No significant matches NP_287060.1 No significant matches NP_287064.1 No significant matches NP_287071.1 No significant matches NP_287073.1 No significant matches NP_287079.1 No significant matches NP_287080.1 No significant matches NP_287084.1 No significant matches NP_287086.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter NP_287087.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active NP_287088.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits NP_287089.1 involved in the assembly of the urease metallocenter; possible nickel donor NP_287095.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_287096.1 No significant matches NP_287097.1 No significant matches NP_287098.1 No significant matches NP_287099.1 No significant matches NP_287100.1 No significant matches NP_287108.1 No significant matches NP_287121.1 IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor NP_287123.1 No significant matches NP_287125.1 No significant matches NP_287127.1 No significant matches NP_287128.1 No significant matches NP_287129.1 No significant matches NP_287130.1 No significant matches NP_287131.1 No significant matches NP_287132.1 No significant matches NP_287136.1 No significant matches NP_287137.1 No significant matches NP_287138.1 No significant matches NP_287139.1 No significant matches NP_287140.1 No significant matches NP_287144.1 No significant matches NP_287148.1 No significant matches NP_287149.1 No significant matches NP_287152.1 No significant matches NP_287172.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex NP_287173.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex NP_287174.1 activates the csgBA and csgDEFG operons involved in biofilm formation NP_287175.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface NP_287177.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers NP_287181.1 required for the transfer of succinyl residues to the glucan backbone NP_287182.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan NP_287183.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space NP_287188.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA NP_287193.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids NP_287194.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing NP_287196.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis NP_287198.1 cofactor involved in the reduction of disulfides NP_287199.2 Confers resistance to norfloxacin and enoxacin NP_287205.1 regulates the flagellar specific sigma28 transcription factor NP_287206.1 required for the assembly of the flagellar basal body P-ring NP_287207.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella NP_287208.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod NP_287209.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production NP_287210.1 the hook connects flagellar basal body to the flagellar filament NP_287211.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod NP_287212.1 makes up the distal portion of the flagellar basal body rod NP_287213.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod NP_287214.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum NP_287215.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space NP_287216.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook NP_287217.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes NP_287218.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase NP_287220.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA NP_287221.2 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell NP_287223.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not NP_287224.2 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY NP_287225.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs NP_287227.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis NP_287228.1 carries the fatty acid chain in fatty acid biosynthesis NP_287229.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP NP_287230.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate NP_287232.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) NP_287233.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA NP_287235.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel NP_287240.1 catalyzes the phosphorylation of thiamine to thiamine phosphate NP_287241.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides NP_287250.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane NP_287251.2 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone NP_287252.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane NP_287253.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine NP_287254.1 Modulates the activities of several enzymes which are inactive in their acetylated form NP_287255.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate NP_287256.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component NP_287258.1 No significant matches NP_287259.1 No significant matches NP_287260.1 No significant matches NP_287268.1 No significant matches NP_287271.1 No significant matches NP_287274.1 No significant matches NP_287290.1 No significant matches NP_287293.1 No significant matches NP_287295.1 No significant matches NP_287304.1 No significant matches NP_287305.1 No significant matches NP_287309.1 No significant matches NP_287311.1 No significant matches NP_287313.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats NP_287316.1 No significant matches NP_287317.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component NP_287318.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase NP_287319.1 catalyzes the release of the N-terminal amino acid from a tripeptide NP_287323.1 No significant matches NP_287324.1 No significant matches NP_287325.1 No significant matches NP_287326.1 No significant matches NP_287327.1 No significant matches NP_287328.1 No significant matches NP_287329.1 No significant matches NP_287331.1 No significant matches NP_287335.1 No significant matches NP_287340.1 No significant matches NP_287341.1 No significant matches NP_287342.1 No significant matches NP_287344.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress NP_287345.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide NP_287346.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis NP_287347.2 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs NP_287349.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA NP_287350.1 Converts isocitrate to alpha ketoglutarate NP_287355.1 member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation NP_287357.1 DLP12 prophage NP_287358.1 DLP12 prophage; Holliday junction resolvase NP_287382.1 No significant matches NP_287408.1 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA NP_287413.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell NP_287414.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums NP_287415.1 blocks the formation of polar Z-ring septums NP_287421.1 Acts by forming a pore-like structure upon contact with mammalian cells NP_287422.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization NP_287423.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization NP_287424.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein NP_287425.1 involved in regulation of intracellular pH under alkaline conditions NP_287426.1 Multifunctional regulator of fatty acid metabolism NP_287428.1 catalyzes the oxidative deamination of D-amino acids NP_287429.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA NP_287430.2 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli NP_287431.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine NP_287438.1 involved in molybdenum transport NP_287443.1 No significant matches NP_287445.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL NP_287446.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone NP_287447.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase NP_287449.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 NP_287450.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation NP_287451.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function NP_287452.1 role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport NP_287453.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP NP_287454.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis NP_287455.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein NP_287456.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins NP_287457.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 NP_287458.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB NP_287461.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis NP_287462.1 No significant matches NP_287463.1 No significant matches NP_287465.1 in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions NP_287469.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase NP_287477.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine NP_287481.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose NP_287483.1 catalyzes the formation of thymidine 5'-phosphate from thymidine NP_287491.2 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein NP_287492.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) NP_287494.2 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity NP_287495.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins NP_287496.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase of proteins NP_287497.1 Involved in cell division; probably involved in intracellular septation NP_287499.1 receptor for colicin S4 NP_287504.1 No significant matches NP_287505.1 No significant matches NP_287507.1 No significant matches NP_287508.1 The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown. NP_287514.1 No significant matches NP_287520.1 No significant matches NP_287526.1 No significant matches NP_287534.1 No significant matches NP_287545.1 No significant matches NP_287546.1 No significant matches NP_287555.1 No significant matches NP_287560.1 No significant matches NP_287563.1 No significant matches NP_287564.1 No significant matches NP_287565.1 No significant matches NP_287572.1 No significant matches NP_287573.1 No significant matches NP_287575.1 No significant matches NP_287577.1 No significant matches NP_287579.1 No significant matches NP_287581.1 No significant matches NP_287582.1 No significant matches NP_287611.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine NP_287616.1 upregulated by FixLJ/FixK under oxygen limitation; involved in regulation of genes involved in carbon and amino acid metabolism NP_287617.1 No significant matches NP_287618.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters NP_287621.2 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF NP_287622.2 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes NP_287623.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function NP_287628.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase NP_287629.1 catalyzes the formation of glutamate from glutamine NP_287631.1 No significant matches NP_287633.2 catalyzes the formation of D-tagaturonate from D-altronate NP_287635.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate NP_287654.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase NP_287656.1 regulates the cellular response to acid resistance NP_287666.1 heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate NP_287667.1 catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis NP_287675.1 protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase NP_287676.2 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate NP_287677.2 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs NP_287679.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase NP_287696.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown NP_287699.1 No significant matches NP_287705.1 No significant matches NP_287717.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation NP_287730.1 with TehA confers resistance to tellurite NP_287736.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans NP_287744.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm NP_287746.1 NAD-linked NP_287748.1 No significant matches NP_287749.1 No significant matches NP_287750.1 No significant matches NP_287751.1 No significant matches NP_287752.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain NP_287753.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds NP_287762.1 No significant matches NP_287766.1 Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthes NP_287799.1 No significant matches NP_287800.1 No significant matches NP_287802.1 No significant matches NP_287809.1 No significant matches NP_287811.1 No significant matches NP_287812.1 No significant matches NP_287813.1 No significant matches NP_287814.1 No significant matches NP_287815.1 No significant matches NP_287819.1 No significant matches NP_287820.1 No significant matches NP_287821.1 No significant matches NP_287823.1 acts to load the DnaB helicase onto the intiation site durning DNA replication NP_287831.1 Rac prophage Kil protein; Kil overexpression leads to morphological defects and inhibits cell division NP_287832.1 Rac prophage hypothetical protein NP_287833.1 The RecE (also known as exonuclease VIII) pathway is an alternative pathway for the initiation of homologous recombination in Escherichia coli. The RecE pathway is activated in recB, recC sbcA (suppressors of recB and recC) mutants. Activation of the RecE pathway results in the production of at least two phage proteins relevant for recombinational repair. RecE is a duplex DNA-specific exonuclease which produces 3' overhangs in duplex DNA by preferentially degrading the 5'-ending strands. Recombinational repair of E.coli chromosomal DNA involves as well other proteins: RecA, RecF, RecJ, RecO, RecR, and RuvC. NP_287835.1 seems to be involved in restriction alleviation and enhancement of modification by EcoKI, but not in restriction alleviation of type III restriction systems; Rac prophage NP_287836.1 Rac prophage NP_287839.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs NP_287840.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA NP_287852.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia NP_287853.1 with UspC and UspD is involved in resistance to UV irradiation NP_287864.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein NP_287865.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids NP_287880.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide NP_287882.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock NP_287883.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding NP_287884.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF NP_287885.2 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor NP_287886.1 putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate NP_287888.1 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation NP_287889.1 regulates genes involved in putrescine degradation NP_287890.1 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate NP_287907.1 No significant matches NP_287908.1 Catalyzes a key regulatory step in fatty acid biosynthesis NP_287910.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction NP_287911.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP NP_287912.1 No significant matches NP_287915.1 involved in start site selection during the initiation of translation NP_287916.1 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase NP_287920.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate NP_287921.1 Catalyzes the conversion of citrate to isocitrate NP_287922.1 No significant matches NP_287923.1 No significant matches NP_287924.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation NP_287925.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity NP_287927.1 SohB; periplasmic protein; member of the peptidase S49 family NP_287929.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide NP_287930.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA NP_287935.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine NP_287936.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis NP_287937.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate NP_287938.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate NP_287939.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis NP_287944.1 No significant matches NP_287951.1 No Hits NP_287980.1 No Hits NP_287998.1 No Hits NP_288003.1 acts to load the DnaB helicase onto the intiation site durning DNA replication NP_288026.2 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane NP_288028.2 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium NP_288032.2 required for growth and survival under moderately acid conditions NP_288034.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS NP_288035.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS NP_288036.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes NP_288037.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme NP_288038.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm NP_288043.1 response regulator in two-component regulatory system with RstB NP_288045.1 binds to DNA replication terminator sequences to prevent passage of replication forks NP_288046.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle NP_288055.1 Acts on the hydroxyl group at position 7 of the steroid frame NP_288056.1 regulates malXY which are involved in maltose-glucose transport NP_288057.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site NP_288059.1 catalyzes the formation of inosine from adenosine NP_288061.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes NP_288064.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen NP_288065.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen NP_288066.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents NP_288067.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen NP_288068.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase NP_288069.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines NP_288070.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation NP_288072.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal NP_288073.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) NP_288074.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate NP_288076.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling NP_288078.2 Transcription regulator that can both activate or repress expression NP_288082.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water NP_288086.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide NP_288087.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione NP_288088.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) NP_288089.1 similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli NP_288092.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals NP_288094.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers NP_288096.1 uncharacterized member of the major facilitator superfamily (MFS) NP_288097.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge NP_288098.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine NP_288099.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones NP_288110.1 catalyzes the formation of phosphoenolpyruvate from pyruvate NP_288113.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine NP_288114.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine NP_288115.1 with SufBC activates cysteine desulfurase SufS NP_288116.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE NP_288117.1 with SufCD activates cysteine desulfurase SufS NP_288118.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein NP_288122.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function NP_288126.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate NP_288127.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis NP_288129.2 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain NP_288131.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain NP_288132.1 May play a role in a redox process NP_288135.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids NP_288136.1 catalyzes the formation of phosphoenolpyruvate from pyruvate NP_288138.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate NP_288143.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell NP_288144.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane NP_288145.1 with BtuD and BtuF transports vitamin B12 into the cell NP_288146.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control NP_288147.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily NP_288148.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily NP_288150.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit NP_288152.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits NP_288153.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_288160.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate NP_288165.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide NP_288168.1 represses the celABCDF-ydjC operon involved in carbon uptake NP_288169.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake NP_288170.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake NP_288171.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake NP_288172.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein NP_288173.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers NP_288174.1 3' incision activity; acts with UvrC NP_288176.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP NP_288177.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism NP_288178.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation NP_288179.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH NP_288181.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate NP_288182.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction NP_288194.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer NP_288196.1 decatenates replicating daughter chromosomes NP_288197.1 catalyzes the formation of selenophosphate from selenide and ATP NP_288199.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane NP_288201.1 converts asparagine to aspartate and ammonia NP_288202.2 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide NP_288214.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress NP_288215.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate NP_288237.1 member of the betaine, carnitine, choline transporter (BCCT) family; unknown function NP_288241.1 Activates fatty acids by binding to coenzyme A NP_288248.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine NP_288255.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel NP_288257.1 membrane protein YebN NP_288258.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth NP_288263.1 No significant matches NP_288266.1 metalloprotease NP_288267.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 NP_288268.1 affects solute and DNA transport through an unknown mechanism NP_288272.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA NP_288275.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins NP_288281.1 3'-5' exonuclease activity on single or double-strand DNA NP_288282.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues NP_288284.1 secreted protein; unknown function NP_288286.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis NP_288287.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate NP_288288.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate NP_288289.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate NP_288290.1 Represses the expression of the zwf, eda, glp and gap NP_288291.1 catalyzes the formation of phosphoenolpyruvate from pyruvate NP_288292.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA NP_288294.2 involved in transport of zinc(II) with ZnuA and C NP_288295.1 involved in transport of zinc(II) with ZnuA and C NP_288296.1 involved in transport of zinc(II) with ZnuA and C NP_288297.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration NP_288298.1 plays an essential role in ATP-dependent branch migration of the Holliday junction NP_288300.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity NP_288302.1 converts dATP to dAMP and pyrophosphate NP_288303.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes NP_288313.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase NP_288316.1 membrane protein involved in the flagellar export apparatus NP_288317.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export NP_288318.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation NP_288319.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble NP_288320.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins NP_288321.1 methylates the MCP NP_288322.1 mediates taxis toward dipeptides NP_288325.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component NP_288326.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine NP_288327.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine NP_288328.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems NP_288329.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems NP_288331.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress NP_288333.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature NP_288334.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose NP_288335.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose NP_288340.1 cytoplasmic iron storage protein NP_288345.1 No significant matches NP_288346.1 No significant matches NP_288349.1 No significant matches NP_288350.1 No significant matches NP_288351.1 No significant matches NP_288352.1 No significant matches NP_288353.1 No significant matches NP_288354.1 No significant matches NP_288355.1 No significant matches NP_288372.1 No significant matches NP_288374.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision NP_288375.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system NP_288377.1 regulates genes involved in cell division NP_288380.2 catalyzes the formation of pyruvate from D-cysteine NP_288382.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence NP_288383.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes NP_288384.1 structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes NP_288385.1 involved in flagellin assembly NP_288386.1 flagellin specific chaperone NP_288387.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family NP_288388.1 converts 1,4-alpha-D-glucans to maltodextrin NP_288398.1 forms a junction between the M-ring and FlgB during flagella biosynthesis NP_288399.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod NP_288400.1 One of three proteins involved in switching the direction of the flagellar rotation NP_288401.2 binds to and inhibits the function of flagella specific ATPase FliI NP_288402.2 involved in type III protein export during flagellum assembly NP_288403.1 rod/hook and filament chaperone NP_288405.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring NP_288406.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation NP_288407.1 One of three proteins involved in switching the direction of the flagellar rotation NP_288408.2 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus NP_288409.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus NP_288410.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus NP_288411.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus NP_288415.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate NP_288426.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress NP_288428.2 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced NP_288430.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ NP_288431.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme NP_288433.1 No significant matches NP_288435.1 No significant matches NP_288436.1 No significant matches NP_288452.1 No significant matches NP_288453.1 No significant matches NP_288454.1 No significant matches NP_288460.1 No significant matches NP_288462.1 No significant matches NP_288467.1 No significant matches NP_288472.1 No significant matches NP_288473.1 No significant matches NP_288475.1 No significant matches NP_288476.1 No significant matches NP_288488.1 No significant matches NP_288491.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile NP_288495.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB NP_288496.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation NP_288498.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole NP_288499.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole NP_288500.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP NP_288511.1 No significant matches NP_288515.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains NP_288516.2 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates NP_288522.1 No significant matches NP_288524.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors NP_288525.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer NP_288526.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis NP_288527.2 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate NP_288528.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide NP_288529.2 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide NP_288530.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase NP_288531.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis NP_288534.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate NP_288547.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose NP_288549.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid NP_288553.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid NP_288560.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit) NP_288562.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance NP_288564.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium NP_288566.2 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide) NP_288567.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis NP_288572.2 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs NP_288573.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis NP_288574.2 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor NP_288575.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction NP_288576.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine NP_288581.1 No significant matches NP_288582.2 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate NP_288583.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate NP_288584.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate NP_288587.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport NP_288591.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role NP_288593.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate NP_288595.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel NP_288596.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel NP_288598.2 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway NP_288599.2 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate NP_288605.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine NP_288606.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP NP_288607.1 No significant matches NP_288608.1 No significant matches NP_288609.1 No significant matches NP_288610.1 No significant matches NP_288612.1 membrane protein conferring nickel and cobalt resistance NP_288620.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content NP_288638.1 unknown function; when overproduced it confers drug-resistance NP_288650.1 No significant matches NP_288658.1 No significant matches NP_288660.1 No significant matches NP_288663.2 No significant matches NP_288664.1 No significant matches NP_288668.1 No significant matches NP_288677.1 No significant matches NP_288682.1 No significant matches NP_288687.1 No significant matches NP_288688.1 No significant matches NP_288701.1 No significant matches NP_288702.1 No significant matches NP_288710.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent NP_288711.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7 NP_288715.4 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride NP_288716.1 No significant matches NP_288718.1 catalyzes the formation of catechol from salicylate NP_288726.2 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis NP_288729.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain NP_288730.2 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines NP_288731.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex NP_288732.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains NP_288734.1 negative regulator of the mglBAC operon for galactose utilization NP_288736.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer NP_288738.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein NP_288742.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues NP_288745.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively NP_288746.1 activator of nucleoside metabolism NP_288750.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel NP_288751.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers NP_288752.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr NP_288754.2 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein NP_288758.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance NP_288765.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance NP_288766.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA NP_288768.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response NP_288773.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes NP_288777.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane NP_288781.1 ATP-binding protein; required for proper cytochrome c maturation NP_288782.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone NP_288783.2 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA NP_288784.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA NP_288785.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway NP_288786.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC NP_288788.1 Predicted role in electron transfer to the periplasmic nitrate reductase NapA. NP_288789.1 serine protease inhibitor, inhibits trypsin and other proteases NP_288790.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate NP_288791.1 efflux pump for the antibacterial peptide microcin J25 NP_288794.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway NP_288795.1 allows for ions and hydrophilic solutes to cross the outer membrane NP_288797.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF NP_288805.1 negatively supercoils closed circular double-stranded DNA NP_288806.1 Involved in ubiquinone biosynthesis NP_288808.1 Catalyzes the rate-limiting step in dNTP synthesis NP_288809.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA NP_288810.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases NP_288814.1 No significant matches NP_288815.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic NP_288816.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell NP_288817.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor NP_288818.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters NP_288819.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate NP_288829.2 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose NP_288830.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate NP_288831.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains NP_288833.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A NP_288834.1 No significant matches NP_288839.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate NP_288840.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA NP_288841.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA NP_288842.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis NP_288843.3 synthesizes isochorismate acid from chorismate NP_288846.2 member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions NP_288847.1 ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system NP_288850.2 Catalyzes the transfer of electrons from NADH to quinone NP_288851.1 Catalyzes the transfer of electrons from NADH to quinone NP_288852.1 Catalyzes the transfer of electrons from NADH to ubiquinone NP_288853.1 Catalyzes the transfer of electrons from NADH to quinone NP_288854.1 Catalyzes the transfer of electrons from NADH to quinone NP_288855.1 Catalyzes the transfer of electrons from NADH to quinone NP_288856.1 Catalyzes the transfer of electrons from NADH to quinone NP_288857.1 Catalyzes the transfer of electrons from NADH to quinone NP_288858.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase NP_288859.1 Catalyzes the transfer of electrons from NADH to quinone NP_288860.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms NP_288861.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen NP_288862.1 Catalyzes the transfer of electrons from NADH to quinone NP_288864.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor NP_288870.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA NP_288871.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate NP_288877.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate NP_288885.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate NP_288886.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway NP_288887.1 membrane protein required for colicin V production NP_288890.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits NP_288892.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability NP_288894.1 catalyzes the formation of 3-hydroxy-4-phospho-hydroxy-alpha-ketobutyrate from erythronate-4-phosphate NP_288895.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein NP_288897.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP NP_288898.2 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules NP_288902.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm NP_288903.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis NP_288904.1 involved in methylation of ribosomal protein L3 NP_288914.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate NP_288915.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth NP_288925.1 No significant matches NP_288926.1 No significant matches NP_288927.1 No significant matches NP_288928.1 No significant matches NP_288929.1 No significant matches NP_288931.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments NP_288932.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least NP_288936.1 catalyzes the formation of pyruvate from serine NP_288939.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance NP_288942.1 member of the AEC family of auxin efflux transporters; unknown function NP_288943.1 catalyzes the formation of formyl-CoA from oxalyl-CoA NP_288944.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA NP_288948.2 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock NP_288954.1 metalloprotein NP_288955.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase NP_288958.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate NP_288968.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation NP_288972.1 No significant matches NP_288973.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB NP_288974.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure NP_288975.1 role in sulfur assimilation NP_288976.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis NP_288978.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system NP_288979.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose NP_288980.2 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal NP_288982.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide NP_288984.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import NP_288989.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway NP_288990.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component NP_288997.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis NP_288998.1 activates the transcription of the ethanolamine utilization operon NP_289001.1 catalyzes the formation of acetaldehyde from ethanolamine NP_289003.1 ethanolamine utilization protein EutA NP_289010.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta NP_289015.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate NP_289016.1 Maintains the balance of metabolites in the pentose-phosphate pathway NP_289017.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase NP_289020.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic) NP_289024.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. NP_289026.2 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate NP_289029.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase NP_289031.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis NP_289032.2 negative transcriptional regulator of the gcvTHP operon NP_289033.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine NP_289035.1 Catalyzes the transfer of electrons from NADH to ubiquinone NP_289038.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide NP_289039.1 Catalyzes the transfer of electrons from NADH to ubiquinone NP_289041.1 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far NP_289045.1 inner membrane protein presumed to act as a formate transporter; member of the hyf operon NP_289049.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP NP_289051.2 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate NP_289052.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis NP_289053.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate NP_289054.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate NP_289057.1 No significant matches NP_289061.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway NP_289062.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate NP_289063.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides NP_289064.2 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains NP_289065.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis NP_289067.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG NP_289068.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis NP_289070.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance NP_289071.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate NP_289072.1 No significant matches NP_289076.2 penicillin-insensitive transglycosylase/transpeptidase NP_289078.2 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds NP_289079.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I NP_289080.2 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide NP_289083.1 involved in the maturation of iron-sulfur cluster-containing proteins NP_289084.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins NP_289085.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein NP_289087.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis NP_289088.1 regulates the expression of the iscRSUA operon NP_289092.1 transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters NP_289093.1 activator of 3-phenylpropionic acid catabolism NP_289097.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate NP_289107.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate NP_289108.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine NP_289109.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA NP_289113.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis NP_289114.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function NP_289119.1 No significant matches NP_289120.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids NP_289121.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) NP_289122.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA NP_289123.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome NP_289124.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity NP_289125.1 No significant matches NP_289126.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins NP_289127.1 binds to the ribosome on the universally-conserved alpha-sarcin loop NP_289128.1 involved in the reduction of the SoxR iron-sulfur cluster NP_289129.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP NP_289131.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response NP_289132.1 catalyzes the formation of oxaloacetate from L-aspartate NP_289134.1 facilitates an early step in the assembly of the 50S subunit of the ribosome NP_289137.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit NP_289138.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine NP_289140.1 No significant matches NP_289144.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome NP_289149.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA NP_289150.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline NP_289151.1 associated with 30S ribosomal subunit; interferes with translation elongation NP_289152.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis NP_289153.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis NP_289154.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive NP_289159.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site NP_289160.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA NP_289161.2 Essential for efficient processing of 16S rRNA NP_289162.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity NP_289163.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins NP_289166.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor NP_289167.1 catalyzes the phosphorylation of NAD to NADP NP_289172.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation NP_289174.1 No significant matches NP_289185.1 No significant matches NP_289192.1 No significant matches NP_289193.1 No significant matches NP_289194.1 No significant matches NP_289195.1 No significant matches NP_289196.1 No significant matches NP_289197.1 No significant matches NP_289198.1 No significant matches NP_289201.1 No significant matches NP_289205.1 No significant matches NP_289208.2 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution NP_289209.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate NP_289210.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent NP_289211.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate NP_289214.2 regulator of gab gene expression NP_289226.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF NP_289227.1 Catalyzes the rate-limiting step in dNTP synthesis NP_289228.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE NP_289229.1 with ProWX is involved in the high-affinity uptake of glycine betaine NP_289230.1 with ProVX is involved in the high-affinity uptake of glycine betaine NP_289231.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine NP_289235.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB NP_289238.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 NP_289239.1 involved in the first step of glutathione biosynthesis NP_289241.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent NP_289242.1 affects carbohydrate metabolism; has regulatory role in many processes NP_289243.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_289244.1 No significant matches NP_289245.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities NP_289246.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs NP_289248.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan NP_289253.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel NP_289254.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate NP_289255.1 regulator for glucitol utilization NP_289256.1 regulates genes involved in glucitol utilization NP_289257.2 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate NP_289258.2 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon NP_289259.1 detoxifies nitric oxide using NADH NP_289260.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase NP_289262.1 involved in electron transport from formate to hydrogen NP_289264.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel NP_289266.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE NP_289269.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate NP_289272.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3) NP_289274.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon NP_289275.1 No significant matches NP_289276.1 plays a role in hydrogenase nickel cofactor insertion NP_289277.1 GTP hydrolase involved in nickel liganding into hydrogenases NP_289278.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase NP_289283.1 No significant matches NP_289284.1 This protein performs the mismatch recognition step during the DNA repair process NP_289290.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses NP_289291.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus NP_289292.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins NP_289293.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate NP_289294.1 catalyzes the modification of U13 in tRNA(Glu) NP_289295.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate NP_289296.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers NP_289297.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein NP_289299.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis NP_289300.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ NP_289301.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP NP_289302.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3 NP_289308.1 No significant matches NP_289312.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite NP_289313.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide NP_289314.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity NP_289333.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_289334.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer NP_289335.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era NP_289336.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system NP_289337.1 part of the MazF-MazE toxin-antitoxin system; conteracts MazF NP_289338.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP NP_289339.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] NP_289340.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system NP_289345.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group NP_289346.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp NP_289348.1 SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function NP_289349.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis NP_289353.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups NP_289355.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate NP_289357.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose NP_289360.1 regulates expression of genes involved in L-fucose utilization NP_289363.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence NP_289368.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues NP_289370.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis NP_289371.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity NP_289372.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity NP_289374.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination NP_289379.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived NP_289380.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein NP_289381.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr NP_289382.1 hydrolyzes diadenosine polyphosphate NP_289383.1 No significant matches NP_289384.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair NP_289387.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH NP_289389.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 NP_289390.1 controls transcription of galETKM NP_289391.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding NP_289392.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase NP_289395.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate NP_289396.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate NP_289397.2 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis NP_289403.1 No significant matches NP_289410.1 No significant matches NP_289416.1 No significant matches NP_289417.1 No significant matches NP_289418.1 Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins NP_289422.1 part of a type III secretory system probably involved in invasion into eukaryotic cells NP_289423.1 involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells NP_289425.1 No significant matches NP_289427.1 Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase NP_289432.1 No significant matches NP_289436.1 molybdenum cofactor-binding protein; participates in purine salvage NP_289437.2 FAD-binding subunit; with XdhA and XdhC participates in purine salvage NP_289438.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage NP_289440.1 catalyzes the formation of L-citruline from L-ornithine and carbamoylphosphate NP_289441.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate NP_289442.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases NP_289443.2 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position NP_289444.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP NP_289448.1 with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase NP_289449.2 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS NP_289450.1 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain NP_289451.1 with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration NP_289453.1 Catalyzes the deamination of guanine NP_289456.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic) NP_289458.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate NP_289459.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 NP_289460.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 NP_289461.1 5'-3' single-stranded-DNA-specific exonuclease NP_289462.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity NP_289463.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs NP_289464.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic NP_289467.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator NP_289471.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine NP_289472.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor NP_289473.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein NP_289475.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone NP_289476.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide NP_289477.2 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown NP_289479.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function NP_289481.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate NP_289482.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway NP_289483.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport NP_289484.1 MDM; functions in conversion of succinate to propionate NP_289485.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins NP_289486.2 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA NP_289490.1 Involved in the export of arginine NP_289491.1 participates in the regulation of osmotic pressure changes within the cel NP_289492.2 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate NP_289493.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway NP_289494.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate NP_289505.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein NP_289506.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase NP_289508.1 catalyzes the formation of putrescine from agmatine NP_289509.1 No significant matches NP_289510.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis NP_289514.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase NP_289518.2 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase NP_289519.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione NP_289521.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function NP_289526.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine NP_289527.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III NP_289529.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis NP_289532.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine NP_289535.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues NP_289545.1 No significant matches NP_289547.1 No significant matches NP_289548.1 No significant matches NP_289550.1 No significant matches NP_289554.1 No significant matches NP_289566.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction NP_289567.1 YghU; B2989; one of eight glutathione transferases from E. coli NP_289569.1 plays a role in hydrogenase nickel cofactor insertion NP_289571.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC) NP_289572.1 involved in hydrogen uptake NP_289573.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits NP_289574.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2 NP_289575.1 involved in hydrogen uptake NP_289582.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell NP_289583.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell NP_289585.1 catalyzes the formation of L-homocysteine from cystathionine NP_289589.2 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate NP_289596.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_289597.1 YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system NP_289600.1 QseB; response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes NP_289601.1 QseC NP_289610.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_289611.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate NP_289614.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose NP_289615.2 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell NP_289619.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine NP_289621.1 No significant matches NP_289622.1 DHBP synthase; functions during riboflavin biosynthesis NP_289624.1 Involved in glycogen synthesis. May be involved in glycogen priming NP_289627.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose NP_289628.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme NP_289631.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases NP_289632.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell NP_289633.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin NP_289634.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX NP_289635.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol NP_289636.1 Involved in the tartrate degradation pathway NP_289637.1 Involved in the tartrate degradation pathway NP_289639.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity NP_289640.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA NP_289641.1 synthesizes RNA primers at the replication forks NP_289642.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria NP_289647.2 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate NP_289650.2 in Escherichia coli this is the second beta-galactosidase system NP_289651.1 in Escherichia coli this is the second beta-galactosidase system NP_289663.1 involved in the import of serine and threonine coupled with the import of sodium NP_289666.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism NP_289668.2 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization. NP_289687.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism NP_289688.1 involved in the import of threonine and serine in combination with the import of a proton NP_289689.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic NP_289690.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation NP_289691.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon NP_289696.2 catalyzes the reduction of tartronate semialdehyde to glycerate NP_289697.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate NP_289700.1 SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation NP_289702.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons NP_289704.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport NP_289710.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway NP_289711.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport NP_289712.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport NP_289713.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport NP_289725.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein NP_289737.1 tryptophan transporter of high affinity NP_289738.2 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division NP_289739.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing NP_289741.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence NP_289742.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs NP_289743.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock NP_289744.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NP_289745.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination NP_289746.2 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins NP_289747.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis NP_289750.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate NP_289751.2 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate NP_289752.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins NP_289753.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit NP_289754.1 RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability NP_289755.2 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus NP_289756.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains NP_289757.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication NP_289759.1 involved in the peptidyltransferase reaction during translation NP_289762.1 activator of maltose metabolism genes NP_289763.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_289769.1 ATP-binding subunit of a ABC toluene efflux transporter NP_289770.1 YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers NP_289772.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis NP_289774.1 LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system NP_289776.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen NP_289777.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing NP_289782.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan NP_289784.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA NP_289786.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate NP_289787.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate NP_289790.2 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein NP_289791.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate NP_289793.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid NP_289794.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization NP_289795.1 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic NP_289797.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation NP_289798.1 forms a direct contact with the tRNA during translation NP_289799.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit NP_289804.1 oxidizes malate to oxaloacetate NP_289805.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes NP_289808.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate NP_289809.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate NP_289810.2 membrane protein AaeX; the gene is a member of the aaeXAB operon NP_289811.1 QseA NP_289812.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA NP_289814.2 involved in the processing of the 5'end of 16S rRNA NP_289815.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell NP_289816.1 part of cell wall structural complex MreBCD; transmembrane component NP_289817.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall NP_289818.2 functions in MreBCD complex in some organisms NP_289819.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules NP_289823.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism NP_289824.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism NP_289826.2 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase NP_289827.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype NP_289829.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription NP_289843.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate NP_289844.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA NP_289848.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_289849.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth NP_289850.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase NP_289851.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain NP_289852.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock NP_289853.2 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators NP_289855.1 is a component of the macrolide binding site in the peptidyl transferase center NP_289856.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme NP_289857.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination NP_289858.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 NP_289859.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA NP_289860.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif NP_289861.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_289862.1 late assembly protein NP_289863.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 NP_289864.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance NP_289865.1 binds 5S rRNA along with protein L5 and L25 NP_289866.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance NP_289867.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit NP_289868.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif NP_289869.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 NP_289870.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel NP_289871.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase NP_289872.1 primary binding protein; helps mediate assembly; involved in translation fidelity NP_289873.1 one of the stabilizing components for the large ribosomal subunit NP_289874.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e NP_289875.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation NP_289876.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center NP_289877.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA NP_289878.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation NP_289879.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel NP_289880.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA NP_289881.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin NP_289882.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex NP_289884.1 iron storage protein NP_289886.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu NP_289887.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene NP_289888.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit NP_289889.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance NP_289890.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs NP_289891.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs NP_289892.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs NP_289894.1 rotamase NP_289896.1 rotamase NP_289897.1 No significant matches NP_289898.1 involved in potassium efflux NP_289899.1 required for KefB activity NP_289905.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons NP_289907.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate NP_289908.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity NP_289914.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations NP_289915.1 member of the FNT family of formate and nitrite transporters NP_289916.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin NP_289918.1 inner membrane protein possibly involved in fructoselysine transport; member of the flr operon NP_289919.1 catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine NP_289920.1 YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine NP_289922.1 may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes NP_289923.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_289924.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate NP_289925.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate NP_289928.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis NP_289929.2 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis NP_289930.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa NP_289935.2 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits NP_289936.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose NP_289940.2 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers NP_289942.1 No significant matches NP_289943.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP NP_289944.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR NP_289945.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation NP_289946.2 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus NP_289949.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake NP_289952.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis NP_289953.2 involved in high-affinity gluconate transport NP_289954.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source NP_289956.1 amylomaltase; acts to release glucose from maltodextrins NP_289958.1 No significant matches NP_289959.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides NP_289960.1 No significant matches NP_289963.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester NP_289966.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism NP_289967.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity NP_289968.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine NP_289969.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane NP_289970.1 No significant matches NP_289974.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose NP_289975.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate NP_289976.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen NP_289977.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain NP_289978.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde NP_289979.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP) NP_289985.2 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate NP_289989.1 YhhY; regulated by the fur regulator; unknown function NP_289990.1 No significant matches NP_289991.1 No significant matches NP_289992.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides NP_289994.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate NP_289995.2 part of the UgpABCE glycerol-3-phosphate uptake system NP_289996.1 with UgpABC is involved in uptake of glycerol-3-phosphate NP_289997.1 with UgpEC is involved in the uptake of glycerol-3-phosphate NP_289998.1 with UgpACE is involved in the uptake of glycerol-3-phosphate NP_289999.1 No significant matches NP_290000.2 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine NP_290001.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine NP_290002.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine NP_290003.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter NP_290009.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters NP_290010.1 ABC transporter, membrane protein NP_290011.1 ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions NP_290012.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins NP_290013.1 catalyzes the methylation of 16S rRNA at position G966 NP_290017.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury NP_290018.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs NP_290023.1 No significant matches NP_290025.1 No significant matches NP_290028.1 carries the fatty acid chain in fatty acid biosynthesis NP_290031.1 No significant matches NP_290034.1 No significant matches NP_290036.1 No significant matches NP_290037.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP NP_290039.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis NP_290040.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP NP_290043.1 with NikACDE is involved in nickel transport into the cell NP_290044.1 with NikABDE is involved in nickel transport into the cell NP_290045.1 with NikABCE is involved in nickel transport into the cell NP_290046.1 with NikABCD is involved with nickel transport into the cell NP_290047.1 Inhibits transcription at high concentrations of nickel NP_290054.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis NP_290055.1 No significant matches NP_290056.1 No significant matches NP_290065.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress NP_290067.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function NP_290068.1 predicted SAM-dependent methyltransferase NP_290071.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense NP_290072.1 regulates the expression of of the arsRBC involved in resistance to arsenic NP_290075.1 No significant matches NP_290081.1 No significant matches NP_290083.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III NP_290087.1 with HmuTU is involved in the transport of hemin NP_290088.1 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli NP_290090.1 inactive form NP_290093.1 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds NP_290096.1 regulates genes in response to acid and/or during stationary phase NP_290099.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose NP_290105.1 in Escherichia coli this protein is involved in flagellar function NP_290108.1 involved in the transport of C4-dicarboxylates across the membrane NP_290109.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase from E. coli NP_290110.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA NP_290111.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans NP_290112.2 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) NP_290113.2 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis NP_290119.1 No significant matches NP_290121.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides NP_290122.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF NP_290124.1 transports peptides consisting of two or three amino acids NP_290126.2 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide NP_290134.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine NP_290138.2 Involved in the metabolism of aromatic amino acids NP_290143.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA NP_290144.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA NP_290145.1 No significant matches NP_290150.1 catalyzes the interconversion of D-xylose to D-xylulose NP_290151.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity NP_290152.1 with XylFH is part of the high affinity xylose ABC transporter NP_290156.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds NP_290157.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis NP_290159.1 No significant matches NP_290171.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis NP_290181.1 Acts as a repressor of the mtlAD operon NP_290183.1 No significant matches NP_290184.1 No significant matches NP_290187.1 represses the lctPRD operon NP_290188.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration NP_290189.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates NP_290190.1 catalyzes the O-acetylation of serine NP_290191.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate NP_290192.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA NP_290195.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate NP_290199.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism NP_290200.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine NP_290202.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose NP_290203.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core NP_290213.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A NP_290214.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA NP_290215.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases NP_290216.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_290217.1 required for 70S ribosome assembly NP_290218.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase NP_290219.2 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine NP_290220.1 catalyzes the formation of dUMP from dUTP NP_290221.2 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly NP_290222.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate NP_290223.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs NP_290227.2 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+ NP_290228.1 Essential for recycling GMP and indirectly, cGMP NP_290229.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits NP_290231.1 specifically modifies tRNA at position G18 NP_290232.2 catalyzes branch migration in Holliday junction intermediates NP_290233.1 No significant matches NP_290237.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides NP_290238.2 may be involved in the transport of galactosides-pentoses-hexuronides NP_290280.1 member of a type III secretion system which is part of a pathogenicity island in Salmonella, Yersinia and pathogenic Escherichia coli NP_290283.1 part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response NP_290293.1 No significant matches NP_290294.2 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS NP_290300.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type NP_290301.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate NP_290302.1 membrane protein regulates uhpT expression NP_290303.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph NP_290304.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter NP_290305.1 No significant matches NP_290306.1 No significant matches NP_290307.1 No significant matches NP_290308.1 No significant matches NP_290309.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit NP_290310.1 catalyzes the formation of 2-acetolactate from pyruvate NP_290312.1 multidrug efflux protein involved in adaptation to low energy shock NP_290318.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function NP_290324.2 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent NP_290325.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress NP_290328.2 FAD/NAD(P)-binding domain NP_290330.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins NP_290332.1 negatively supercoils closed circular double-stranded DNA NP_290333.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA NP_290334.1 binds the polymerase to DNA and acts as a sliding clamp NP_290335.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. NP_290336.1 in Escherichia coli transcription of this gene is enhanced by polyamines NP_290337.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates NP_290338.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria NP_290339.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE NP_290340.1 No significant matches NP_290342.1 No significant matches NP_290344.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan NP_290345.1 tryptophan transporter of low affinity NP_290346.1 Confers resistance to chloramphenicol NP_290347.1 Involved in anaerobic NO protection NP_290351.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily NP_290353.1 No significant matches NP_290354.1 No significant matches NP_290356.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon NP_290357.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation NP_290358.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions NP_290359.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions NP_290364.1 No significant matches NP_290368.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source NP_290369.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis NP_290370.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane NP_290371.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit NP_290372.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit NP_290373.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit NP_290374.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex NP_290375.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. NP_290376.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 NP_290377.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 NP_290378.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation NP_290379.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA NP_290380.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs NP_290381.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group NP_290382.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase NP_290383.1 catalyzes the formation of asparagine from aspartate and ammonia NP_290384.2 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA NP_290385.2 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase NP_290386.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH NP_290387.2 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source NP_290388.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain NP_290389.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B NP_290390.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system NP_290391.1 catalyzes the formation of D-ribose 5-phosphate from ribose NP_290392.1 DNA-binding transcriptional repressor of ribose metabolism NP_290395.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon NP_290397.1 among the AAA+ ATPases, the YifB protease belongs to the Helix 2 insert clade; unknown function NP_290399.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit NP_290401.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids NP_290402.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis NP_290403.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway NP_290404.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate NP_290405.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis NP_290408.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication NP_290409.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation NP_290410.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation NP_290413.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes NP_290414.1 No significant matches NP_290416.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein NP_290418.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid NP_290422.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis NP_290424.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis NP_290425.1 enterobacterial common antigen polymerase NP_290427.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function NP_290432.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis NP_290433.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis NP_290434.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP NP_290435.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly NP_290437.1 No significant matches NP_290438.2 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate NP_290440.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs NP_290441.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function NP_290442.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. NP_290445.1 responsible for the influx of magnesium ions NP_290446.1 No significant matches NP_290447.1 No significant matches NP_290449.1 No significant matches NP_290450.1 No significant matches NP_290453.1 catalyzes the hydrolysis of phosphatidylcholine NP_290454.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway NP_290457.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates NP_290458.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium NP_290461.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine NP_290463.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway NP_290464.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner NP_290465.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone NP_290467.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions NP_290468.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes NP_290469.2 mediates the export of protein precursors bearing twin-arginine signal peptides NP_290470.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane NP_290471.1 magnesium dependent; not involved in the Sec-independent protein export system NP_290473.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol NP_290474.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin NP_290475.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids NP_290476.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids NP_290477.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters NP_290480.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX NP_290481.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway NP_290482.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis NP_290484.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages NP_290488.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair NP_290489.2 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential NP_290492.2 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III NP_290493.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54 NP_290494.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation NP_290495.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme NP_290500.2 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown NP_290512.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease NP_290513.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine NP_290515.1 No significant matches NP_290516.1 No significant matches NP_290517.1 No significant matches NP_290520.1 required for the formation of active formate dehydrogenase NP_290521.1 cytochrome b556(FDO) component; heme containing NP_290524.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth NP_290526.1 repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system NP_290527.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars NP_290529.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system NP_290533.1 catalyzes the formation of L-rhamnulose from L-rhamnose NP_290534.1 catalyzes the ATP-dependent phosphorylation of rhamnulose NP_290535.1 activates the expression of the rhaBAD operon and rhaT gene NP_290536.1 activates the expression of rhaRS in response to L-rhamnose NP_290538.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals NP_290539.2 transports degraded pectin products into the bacterial cell NP_290541.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors NP_290542.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system NP_290543.2 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates NP_290544.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers NP_290545.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis NP_290548.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate NP_290552.1 with UspC and Usp E is involved in resistance to UV radiation NP_290554.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese NP_290555.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP NP_290558.1 No significant matches NP_290559.1 No significant matches NP_290560.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity NP_290561.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate NP_290562.1 heat shock protein involved in degradation of misfolded proteins NP_290563.1 heat shock protein involved in degradation of misfolded proteins NP_290565.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins NP_290566.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity NP_290567.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_290572.1 No significant matches NP_290574.1 member of the NlpC/P60 superfamily of peptidases NP_290575.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis NP_290576.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine NP_290577.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways NP_290578.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor NP_290582.2 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone NP_290583.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies NP_290586.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site NP_290587.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS NP_290588.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein NP_290590.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog NP_290593.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate NP_290594.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis NP_290595.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate NP_290596.2 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate NP_290597.1 catalyzes the formation of arginine from (N-L-arginino)succinate NP_290598.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA NP_290599.2 catalyzes the conversion of NADPH to NADH NP_290602.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis NP_290604.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs NP_290605.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space NP_290606.2 converts L-glutamate to D-glutamate, a component of peptidoglycan NP_290607.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis NP_290608.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon NP_290609.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis NP_290611.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu NP_290612.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force NP_290613.1 Modulates Rho-dependent transcription termination NP_290614.1 binds directly to 23S ribosomal RNA NP_290615.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA NP_290616.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit NP_290617.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors NP_290618.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme NP_290619.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter NP_290621.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center NP_290622.2 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate NP_290623.2 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate NP_290624.2 catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate NP_290625.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate NP_290626.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine NP_290627.1 binds specifically to the major sigma factor sigma 70; active in stationary phase NP_290628.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates NP_290629.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III NP_290630.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures NP_290632.1 histone-like DNA-binding protein NP_290636.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein NP_290637.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis NP_290638.1 involved in de novo purine biosynthesis NP_290640.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis NP_290641.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle NP_290642.1 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates NP_290643.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol NP_290645.2 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase NP_290646.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity NP_290648.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family NP_290654.1 Converts D-sorbitol-dphosphate to D-fructose-6-phosphate NP_290656.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA NP_290658.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive NP_290659.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family NP_290665.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter NP_290666.1 with MalKFE is involved in the transport of maltose into the cell NP_290667.1 with MalKGE is involved in maltose transport into the cell NP_290668.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis NP_290669.1 with malEFG is involved in import of maltose/maltodextrin NP_290670.1 porin involved in the transport of maltose and maltodextrins NP_290672.1 in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations NP_290673.2 catalyzes the formation of 4-hydroxybenzoate from chorismate NP_290674.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway NP_290675.2 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA NP_290677.1 Represses a number of genes involved in the response to DNA damage NP_290679.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential NP_290680.2 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB NP_290683.2 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia NP_290685.1 unwinds double stranded DNA NP_290686.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer NP_290687.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate NP_290688.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity NP_290691.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate NP_290692.1 binds to single stranded DNA and PriA helcase facilitate replication restart NP_290695.1 regulates genes involved in response to oxidative stress NP_290700.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake NP_290702.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA NP_290703.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552 NP_290704.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia NP_290707.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552 NP_290710.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system NP_290713.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family NP_290714.2 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride NP_290715.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride NP_290720.1 No significant matches NP_290726.1 required for the use of phosphonates and phosphite as phosphorus sources NP_290727.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role NP_290736.1 may be involved in phosphonate uptake and biodegradation NP_290746.1 response regulator in two-component regulatory system with BasS NP_290747.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division NP_290756.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters NP_290757.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration NP_290758.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration NP_290763.1 class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 NP_290766.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein NP_290767.1 regulates the cadBA operon NP_290769.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm NP_290770.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals NP_290771.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB NP_290772.1 catalyzes the formation of fumarate from aspartate NP_290773.2 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein NP_290774.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function NP_290775.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring NP_290776.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth NP_290780.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_290781.1 acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex NP_290782.1 No significant matches NP_290784.1 lipocalin; globomycin-sensitive outer membrane lipoprotein NP_290786.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane NP_290787.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB NP_290788.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB NP_290789.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB NP_290790.2 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA NP_290793.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine NP_290794.2 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity NP_290795.2 3'-5' exoribonuclease specific for small oligoribonuclotides NP_290798.1 possibly involved in cell wall synthesis NP_290800.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex NP_290801.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity NP_290802.1 Stimulates the elongation of poly(A) tails NP_290803.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein NP_290804.1 with HflC inhibits proteolysis of lambda cII protein by FtsH NP_290805.1 with HflK inhibits proteolysis of lambda cII protein by FtsH NP_290807.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis NP_290808.1 negatively regulates the transcription of genes upregulated by nitrosative stress NP_290809.2 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs NP_290810.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA NP_290817.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA NP_290819.2 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility NP_290820.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo NP_290821.1 negative regulator of ulaG and ulaABCDEF NP_290823.2 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr NP_290824.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake NP_290825.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake NP_290826.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization NP_290827.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway NP_290828.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source NP_290830.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 NP_290831.1 binds single-stranded DNA at the primosome assembly site NP_290832.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit NP_290833.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk NP_290835.1 No significant matches NP_290839.2 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides NP_290840.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine NP_290841.1 Involved in anaerobic NO protection and iron metabolism NP_290845.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate NP_290846.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate NP_290851.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress NP_290856.1 part of the toxin-antitoxin ChpB-ChpS system NP_290857.1 toxin of the ChpB-ChpS toxin-antitoxin system NP_290858.1 catalyzes the hydrolysis of pyrophosphate to phosphate NP_290862.1 membrane component of a sugar ABC transporter system NP_290863.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate NP_290866.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD NP_290868.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions NP_290869.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates NP_290871.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel NP_290872.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon NP_290873.1 No significant matches NP_290874.1 P-type ATPase involved in magnesium influx NP_290876.1 involved in the allosteric regulation of aspartate carbamoyltransferase NP_290877.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis NP_290887.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III. NP_290891.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain NP_290892.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB NP_290893.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides NP_290898.1 No significant matches NP_290901.1 No significant matches NP_290902.1 No significant matches NP_290906.1 No significant matches NP_290907.1 No significant matches NP_290909.1 No significant matches NP_290911.1 No significant matches NP_290914.1 No significant matches NP_290915.1 No significant matches NP_290928.1 inversion of on/off regulator of fimA NP_290929.1 inversion of on/off regulator of fimA NP_290938.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate NP_290940.1 regulates the expression of uxuBA NP_290942.1 No significant matches NP_290943.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS NP_290961.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response NP_290970.1 No significant matches NP_290975.2 catalyzes the transfer of phosphoglycerol to the glucan backbone NP_290977.1 acts to load the DnaB helicase onto the initiation site during DNA replication NP_290978.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' NP_290982.2 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin NP_290984.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit NP_290985.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB NP_290986.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18 NP_290987.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily NP_290988.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein NP_290990.1 No significant matches NP_290995.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate NP_290996.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate NP_290997.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose NP_290998.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate NP_290999.1 No significant matches NP_291000.1 in E. coli the lipoate ligase A catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes; creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins NP_291001.1 catalyzes the formation of serine from O-phosphoserine NP_291002.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents NP_291003.2 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide NP_291004.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence NP_291005.2 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan NP_291006.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription NP_291007.2 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog NP_291008.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate NP_291011.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation NP_291012.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation NP_291016.1 member of the SPOUT superfamily of methyltransferases YP_325561.1 conjugal transfer repressor; 97 pct identical amino acid sequence and equal length to FIO1_ECOLI SW: P22707 YP_325562.1 54 pct identical (1 gap) to 23 residues of an approx. 269 aa protein EXOK_RHIME SW: P33693 YP_325563.1 15.6 kDa protein in finO 3' region precursor; 98 pct identical and equal length to YFI3_ECOLI SW: Q99342 YP_325564.1 55 pct identical (0 gaps) to 66 residues of an approx. 72 aa protein HHA_ECOLI SW: P23870 YP_325565.1 98 pct identical (0 gaps) to 57 residues of an approx. 200 aa protein; plasmid R100 miniplasmid pSM1 ORF 4, TRSW: Q52340 YP_325566.1 RepA2 protein; 98 pct identical amino acid sequence and equal length to CPB2_ECOLI SW: P03847 YP_325567.1 RepA6 YP_325568.1 RepA YP_325569.1 95 pct identical to (0 gaps) 64 residues of a 128 aa protein REPA4 locus ECRSC1 accession V00351 YP_325570.1 28 pct identical to 67 residues of a 82 aa protein Y4KO_RHISN SW : P55533 YP_325571.1 81 pct identical (1 gaps) to 42 residues of an approx. 42 aa protein ORF2 fragment TRSW Q47652; plasmid stability locus YP_325572.1 37 pct identical (2 gaps) to 43 residues of an approx. 675 aa protein COP1_ARATH SW: P43254 YP_325574.1 98 pct identical to 188 residues of a 272 aa protein YIS2_SHISO SW: P16940; IS600 YP_325575.1 96 pct identical (0 gaps) to 139 residues of an approx. 426 aa protein transposase of IS91 accession Q47315 YP_325576.1 26 pct identical (1 gaps) to 26 residues of an approx. 1180 aa protein ITA1_RAT SW: P18614 YP_325577.1 100 pct identical to katP ECEHECCTP accession Number X89017 YP_325578.1 100 pct identical (0 gaps) and equal length to an unidentified 129 aa protein, accession X97542 YP_325579.1 96 pct identical to 295 residues of a 296 aa protein TRA6_SHISO SW: P16942, IS629 transposase YP_325580.1 100 pct identical and equal length to a a putative exoprotein-precursor ECDNAPLAS accession X97542 YP_325581.1 42 pct identical (3 gaps) to 35 residues of an approx. 952 aa protein SEN3_YEAST SW: P32565 YP_325582.1 85 pct identical and equal length to ISA2_SHIDY SW: P03829, IS element iso-IS1N YP_325583.1 85 pct identical (0 gaps) to 46 residues of an approx. 78 aa protein PERD_ECOLI SW:P43476, function unknown YP_325584.1 49 pct identical (0 gaps) to 43 residues of an approx. 200 aa FIMB_ECOLI SW: P04742 YP_325585.1 44 pct identical (0 gaps) to 23 residues of an approx. 136 aa protein YM33_MARPO SW: P38475 YP_325586.1 70 pct identical (0 gaps) to 102 residues of an approx. 152 aa protein SHF2 SW: P72437 YP_325587.1 32 pct identical (2 gaps) to 164 residues of an approx. 377 aa protein YPJH_BACSU SW: P42982 YP_325588.1 83 pct identical (0 gaps) to 513 residues of an approx. 577 aa protein YIJP_ECOLI SW: P32678 YP_325589.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA YP_325590.1 32 pct identical (0 gaps) to 57 residues of an approx. 364 aa protein PGLR_COCCA, SW: P26215 YP_325591.1 43 pct identical (17 gaps) to 131 residues of an approx. 904 aa protein TAGA TRSW: Q56595 YP_325592.1 99 pct identical (0 gaps) and equal length to locus ECPO157 accession Y09824 YP_325593.1 100 pct identical to locus ECPO157 accession Y09824, alternate start for etpD chosen in Y09824 YP_325594.1 99 pct identical (0 gaps) and equal length to locus ECPO157 accession Y09824 YP_325595.1 100 pct identical (0 gaps)to locus ECPO157 accession Y09824 YP_325596.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824 YP_325597.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824 YP_325598.1 100 pct identical to locus ECPO157 accession Y09824, different start in Y09824 YP_325599.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824 YP_325600.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824 YP_325601.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824, alternate start in Y09824 YP_325602.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824 YP_325603.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824, alternate start in Y09824 YP_325604.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824 YP_325605.1 97 pct identical (1 gaps) to 112 residues of an approx. 112 aa protein YI91_SHIDY SW: P39213, IS911 YP_325606.1 IS911; ORFB; 91 pct identical (0 gaps) to 265 residues of an approx. 267 aa protein SDIS911, accession X17613 YP_325607.1 99 pct identical (0 gaps) to 168 residues of an 168 aa protein EHEC-hlyC TRSW: Q47460, alternate start in Q47460 YP_325608.1 99 pct identical (0 gaps) and equal length to a protein EHEC-hlyA TRSW: Q47461 YP_325609.1 99 pct identical and equal length to EHEC-hlyB TRSW: Q47462 YP_325610.1 99 pct identical and equal length to EHEC-hlyD TRSW: Q47463 YP_325611.1 49 pct identical (0 gaps) to 41 residues of an approx.164 aa protein PAPX_ECOLI SW: P42193 YP_325612.1 52 pct identical (0 gaps) to 79 residues of an approx. 164 aa protein PAPX_ECOLI SW: P42193 YP_325613.1 47 pct identical (1 gaps) to 32 residues of an approx. 1240 aa protein R31240_1 TRSW: O00114 YP_325614.1 100 pct identical and equal length to a 118 aa protein 'ORF3' locus FPLREPFIB accession M26308 YP_325615.1 96 pct identical and equal length to a 105 aa protein 'ORF5' locus FPLREPFIB accession M26308 YP_325616.2 99 pct identical and equal length to a 317 aa protein 'ORF1' locus FPLREPFIB accession M26308 YP_325617.1 100 pct identical and equal length to a 109 aa protein 'ORF4' locus FPLREPFIB accession M26308 YP_325618.1 32 pct identical (3 gaps) to 51 residues of an approx. 360 aa protein RECA_BRUAB SW: Q04761 YP_325619.1 23 pct identical (4 gaps) to 111 residues of an approx. 247 aa protein LANP_RAT SW: P49911 YP_325620.1 31 pct identical (8 gaps) to 179 residues of an approx. 344 aa protein KFRA TRSW: P71173 YP_325621.1 37 pct identical (0 gaps) to 30 residues of an approx. 680 aa protein PIRA7 accession U96688 YP_325622.1 90 pct identical amino acid sequence and equal length to ECU51588 accession U51588 YP_325623.1 controlled cell death protein; post-segregation toxin; toxin addiction system YP_325624.1 protein D; 98 pct identical amino acid sequence and equal length to REDF_ECOLI SW: P06615 YP_325625.1 97 pct identical amino acid sequence and equal length to TRA6_SHISO SW: P16942, IS629 YP_325626.1 100 pct identical to YIS3_SHISO SW: P16941, an IS629 protein YP_325627.1 100 pct identical to a 51 aa protein of approx. 251 aa protein E1_ECOLI, TRSW: P03856 YP_325628.1 100 pct identical amino acid sequence and equal length to SOPA_ECOLI SW: P08866 YP_325629.1 SopB YP_325630.1 100 pct identical to 25 residues of a 79 aa protein YPF8_ECOLI SW: P08868 YP_325631.1 36 pct identical (4 gaps) to 47 residues of an approx. 616 aa protein VE1_HPV1A SW: P03111 YP_325632.1 29 pct identical (21 gaps) to 521 residues of an approx. 608 aa protein RDPO_SCEOB SW: P19593 YP_325633.1 25 pct identical (21 gaps) to 126 residues of an approx. 160 aa protein CR18_ORYSA SW: Q06397 YP_325634.1 33 pct identical (14 gaps) to 204 residues of an approx. 232 aa TRSW: Q56638 YP_325635.1 28 pct identical (3 gaps) to 101 residues of an approx. 184 aa protein X169_CRIGR SW: P41228 YP_325636.1 31 pct identical (2 gaps) to 60 residues of an approx. 480 aa protein VL2_HPV29 SW: P50800 YP_325637.1 36 pct identical (6 gaps) to 137 residues of an approx. 142 aa protein KLA1_ECOLI SW: P52602 YP_325638.1 25 pct identical (4 gaps) to 109 residues of an approx. 1976 aa protein MYSA_CAEEL SW: P12844 YP_325639.1 20 pct identical (2 gaps) to 96 residues of a 271 aa protein YG5W_YEAST SW: P53335 YP_325640.1 40 pct identical (1 gaps) to 42 residues of a 1051 aa protein EVI1_HUMAN SW: Q03112 YP_325641.1 27 pct identical to 67 residues of a 296 aa protein FIMP TRSW: Q46527 YP_325642.1 29 pct identical (3 gaps) to 139 residues of a 311 aa protein MYRB_MICGR SW: P43433 YP_325643.1 25 pct identical (1 gaps) to 106 residues of a 1807 aa protein VTA2_XENLA SW: P18709 YP_325644.1 95 pct identical (0 gaps) to 141 residues of a 179 aa protein SSBF_ECOLI SW: P18310 YP_325645.1 57 pct identical (1 gaps) to 65 residues of a 80 aa protein TRSW: P75677 YP_325646.2 99 pct identical (0 gaps) and equal length to a 83 aa protein, putative ORF1 TRSW: P96030 YP_325647.1 97 pct identical amino acid sequence and equal length to PSB1_ECOLI SW: P10031 YP_325648.1 PsiA YP_325649.1 Mok; similar to F leading maintenance protein C YP_325650.1 100 pct identical and equal length to an 52 aa protein FLMA_ECOLI, SW: P16077 YP_325651.1 70 pct identical (3 gaps) to 655 residues of an approx. 904 aa protein Q52336 TRSW: Q52336 YP_325652.1 34 pct identical (0 gaps) to 77 residues of an approx. 421 aa protein TOLA_ECOLI SW: P19934 YP_325653.1 77 pct identical (1 gaps) to 91 residues of an approx. 288 aa protein TRA5_ECOLI SW: P05822, IS3 YP_325654.1 70 pct identical (3 gaps) to 120 residues of an approx. 390 aa protein ISTA_ECOLI SW: P15025, IS21 YP_325655.1 22 pct identical (44 gaps) to 444 residues of an approx. 2364 aa protein Clostridium sordellii cytotoxin L TRSW: Q46342 YP_325656.1 85 pct identical (0 gaps) to 68 residues of an approx. 288 aa protein TRA5_ECOLI SW: P05822, IS3 YP_325657.1 96 pct identical (0 gaps) to 84 residues of an approx. 108 aa protein YIS3_SHISO SW: P16941, IS629 YP_325658.1 96 pct identical to 432 residues of a 1756 aa protein TRI1_ECOLI SW: P14565, truncated by insertion of IS629 YP_325659.1 94 pct identical and equal length to TRX1_ECOLI SW: P22709 YP_325660.1 31.7 kDa protein in traX-finO intergenic region; 96 pct identical amino acid sequence and equal length to YPT2_ECOLI SW: Q99390